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Mobilization of hematopoietic stem cells (HSCs) from the bone marrow to the peripheral blood is a complex mechanism that involves adhesive and chemotactic interactions of HSCs as well as their bone marrow microenvironment. In addition to a number of non-genetic factors, genetic susceptibilities also contribute to the mobilization outcome. Identification of genetic factors associated with HSC yield is important to better understand the mechanism behind HSC mobilization. In the present study, we enrolled 148 Korean participants (56 healthy donors and 92 patients) undergoing HSC mobilization for allogeneic or autologous HSC transplantation. Among a total of 53 polymorphisms in 33 candidate genes, one polymorphism (rs11264422) in relaxin/insulin-like family peptide receptor 4 (RXFP4) gene was significantly associated with a higher HSC yield after mobilization in Koreans. However, in a set of 101 Europeans, no association was found between circulating CD34+ cell counts and rs11264422 genotype. Therefore, we suggest that the ethnic differences in subjects’ genetic background may be related to HSC mobilization. In conclusion, the relaxin—relaxin receptor axis may play an important role in HSC mobilization. We believe that the results of the current study could provide new insights for therapies that use relaxin and HSC populations, as well as a better understanding of HSC regulation and mobilization at the molecular level.
The direct evidential "-te" in Korean: Its interaction with person and experiencer predicates
(2012)
This paper discusses the complex relations among the direct evidential "-te", person, and experiencer predicates in Korean. The questions of the paper are: (i) how the three components are related with each other in the evidential sentences, and (ii) how the interactions of the three components can be formally analyzed to correctly license only the well-formed evidential sentences. I show that in direct evidential construction with a non-private predicate (e.g. "pwutulep-" 'soft'), the asserter/epistemic authority (i.e. the speaker "na" 'I' in declarative or the addressee "ne" 'you' in question) must be the experiencer of the predicate, but there is no such constraint in direct evidential construction with a private predicate (e.g. "aphu-" 'sick'). I also show that the direct evidential construction with a non-private predicate is an instance of self-ascription. Then I propose an analysis of the experiencer predicates and associated lexical rules in the Minimal Recursion Semantics (MRS) (Copestake, et al., 2005) of Head-driven Phrase Structure Grammar (HPSG) (Pollard and Sag, 1994; Sag, et al., 2003).
In this paper I present an account for the lexical passive Serial Verb Constructions (SVCs) in Korean. Regarding the issue of how the arguments of an SVC are realized, I propose two hypotheses: i) Korean SVCs are broadly classified into two types, subject-sharing SVCs where the subject is structure-shared by the verbs and index-sharing SVCs where only indices of semantic arguments are structure-shared by the verbs, and ii) a semantic argument sharing is a general requirement of SVCs in Korean. I also argue that an argument composition analysis can accommodate such the new data as the lexical passive SVCs in a simple manner compared to other alternative derivational analyses.