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White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study
(2019)
Hatton, Sean N. ; Huynh, Khoa H. ; Bonilha, Leonardo ; Abela, Eugenio Cecilio ; Alhusaini, Saud ; Altmann, André ; Alvim, Marina K. M. ; Balachandra, Akshara R. ; Bartolini, Emanuele ; Bender, Benjamin ; Bernasconi, Neda ; Bernasconi, Andrea ; Bernhardt, Boris ; Bargallo, Núria ; Caldairou, Benoit ; Caligiuri, Maria Eugenia ; Carr, Sarah J. A. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Concha, Luis ; Davoodi-Bojd, Esmaeil ; Desmond, Patricia M. ; Devinsky, Orrin ; Doherty, Colin P. ; Domin, Martin ; Duncan, John S. ; Focke, Niels K. ; Foley, Sonya F. ; Gambardella, Antonio ; Gleichgerrcht, Ezequiel ; Guerrini, Renzo ; Hamandi, Khalid ; Ishikawa, Akari ; Keller, Simon S. ; Kochunov, Peter V. ; Kotikalapudi, Raviteja ; Kreilkamp, Barbara A. K. ; Kwan, Patrick ; Labate, Angelo ; Langner, Sönke ; Lenge, Matteo ; Liu, Min ; Lui, Elaine ; Martin, Pascal ; Mascalchi, Mario ; Moreira, José Carlos Vasques ; Morita-Sherman, Marcia Elisabete ; O’Brien, Terence J. ; Pardoe, Heath R. ; Pariente Zorrilla, José Carlos ; Ribeiro, Letı́cia F. ; Richardson, Mark Philip ; Rocha, Cristiane S. ; Rodrı́guez-Cruces, Raúl ; Rosenow, Felix ; Severino, Mariasavina ; Sinclair, Benjamin ; Soltanian-Zadeh, Hamid ; Striano, Pasquale ; Taylor, Peter N. ; Thomas, Rhys H. ; Tortora, Domenico ; Velakoulis, Dennis ; Vezzani, Annamaria ; Vivash, Lucy ; Podewils, Felix von ; Vos, Sjoerd B. ; Weber, Bernd ; Winston, Gavin P. ; Yasuda, Clarissa L. ; Thompson, Paul M. ; Jahanshad, Neda ; Sisodiya, Sanjay M. ; McDonald, Carrie R.
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
Hoyle, Christopher Robert ; Fuchs, Claudia ; Järvinen, Emma ; Saathoff, Harald ; Dias, Antonio ; El Haddad, Imad ; Gysel, Martin ; Coburn, Sean C. ; Tröstl, Jasmin ; Bernhammer, Anne-Kathrin ; Bianchi, Federico ; Breitenlechner, Martin ; Corbin, Joel C. ; Craven, Jill ; Donahue, Neil McPherson ; Duplissy, Jonathan ; Ehrhart, Sebastian ; Frege, Carla ; Gordon, Hamish ; Höppel, Niko Florian ; Heinritzi, Martin ; Kristensen, Thomas Bjerring ; Molteni, Ugo ; Nichman, Leonid ; Pinterich, Tamara ; Prévôt, André Stephan Henry ; Simon, Mario ; Slowik, Jay G. ; Steiner, Gerhard ; Tomé, Antonio ; Vogel, Alexander L. ; Volkamer, Rainer ; Wagner, Andrea Christine ; Wagner, Robert ; Wexler, Anthony S. ; Williamson, Christina ; Winkler, Paul M. ; Yan, Chao ; Amorim, Antonio ; Dommen, Josef ; Curtius, Joachim ; Gallagher, Martin William ; Flagan, Richard C. ; Hansel, Armin ; Kirkby, Jasper ; Kulmala, Markku ; Möhler, Ottmar ; Stratmann, Frank ; Worsnop, Douglas R. ; Baltensperger, Urs
The growth of aerosol due to the aqueous phase oxidation of sulfur dioxide by ozone was measured in laboratory-generated clouds created in the Cosmics Leaving OUtdoor Droplets (CLOUD) chamber at the European Organization for Nuclear Research (CERN). Experiments were performed at 10 and −10 °C, on acidic (sulfuric acid) and on partially to fully neutralised (ammonium sulfate) seed aerosol. Clouds were generated by performing an adiabatic expansion – pressurising the chamber to 220 hPa above atmospheric pressure, and then rapidly releasing the excess pressure, resulting in a cooling, condensation of water on the aerosol and a cloud lifetime of approximately 6 min. A model was developed to compare the observed aerosol growth with that predicted using oxidation rate constants previously measured in bulk solutions. The model captured the measured aerosol growth very well for experiments performed at 10 and −10 °C, indicating that, in contrast to some previous studies, the oxidation rates of SO2 in a dispersed aqueous system can be well represented by using accepted rate constants, based on bulk measurements. To the best of our knowledge, these are the first laboratory-based measurements of aqueous phase oxidation in a dispersed, super-cooled population of droplets. The measurements are therefore important in confirming that the extrapolation of currently accepted reaction rate constants to temperatures below 0 °C is correct.
Hoyle, Christopher Robert ; Fuchs, Claudia ; Järvinen, Emma ; Saathoff, Harald ; Dias, Antonio ; El Haddad, Imad ; Gysel, Martin ; Coburn, Sean C. ; Tröstl, Jasmin ; Bernhammer, Anne-Kathrin ; Bianchi, Federico ; Breitenlechner, Martin ; Corbin, Joel C. ; Craven, Jill ; Donahue, Neil McPherson ; Duplissy, Jonathan ; Ehrhart, Sebastian ; Frege, Carla ; Gordon, Hamish ; Höppel, Niko Florian ; Heinritzi, Martin ; Kristensen, Thomas Bjerring ; Molteni, Ugo ; Nichman, Leonid ; Pinterich, Tamara ; Prévôt, André Stephan Henry ; Simon, Mario ; Slowik, Jay G. ; Steiner, Gerhard ; Tomé, Antonio ; Vogel, Alexander L. ; Volkamer, Rainer ; Wagner, Andrea Christine ; Wagner, Robert ; Wexler, Anthony S. ; Williamson, Christina ; Winkler, Paul M. ; Yan, Chao ; Amorim, Antonio ; Dommen, Josef ; Curtius, Joachim ; Gallagher, Martin William ; Flagan, Richard C. ; Hansel, Armin ; Kirkby, Jasper ; Kulmala, Markku ; Möhler, Ottmar ; Stratmann, Frank ; Worsnop, Douglas R. ; Baltensperger, Urs
The growth of aerosol due to the aqueous phase oxidation of sulfur dioxide by ozone was measured in laboratory-generated clouds created in the Cosmics Leaving OUtdoor Droplets (CLOUD) chamber at the European Organization for Nuclear Research (CERN). Experiments were performed at 10 and −10 °C, on acidic (sulfuric acid) and on partially to fully neutralised (ammonium sulfate) seed aerosol. Clouds were generated by performing an adiabatic expansion – pressurising the chamber to 220 hPa above atmospheric pressure, and then rapidly releasing the excess pressure, resulting in a cooling, condensation of water on the aerosol and a cloud lifetime of approximately 6 min. A model was developed to compare the observed aerosol growth with that predicted using oxidation rate constants previously measured in bulk solutions. The model captured the measured aerosol growth very well for experiments performed at 10 and −10 °C, indicating that, in contrast to some previous studies, the oxidation rates of SO2 in a dispersed aqueous system can be well represented by using accepted rate constants, based on bulk measurements. To the best of our knowledge, these are the first laboratory-based measurements of aqueous phase oxidation in a dispersed, super-cooled population of droplets. The measurements are therefore important in confirming that the extrapolation of currently accepted reaction rate constants to temperatures below 0 °C is correct.
Janning, Melanie ; Süptitz, Juliane ; Albers-Leischner, Corinna ; Delpy, Pierre ; Tufman, Amanda L. H. ; Velthaus-Rusik, Janna-Lisa ; Reck, Martin ; Jung, Andreas ; Kauffmann-Guerrero, Diego ; Bonzheim, Irina ; Brändlein, Stephanie ; Hummel, Horst-Dieter ; Wiesweg, Marcel ; Schildhaus, Hans-Ulrich ; Stratmann, Jan Alexander ; Sebastian, Martin ; Alt, Jürgen ; Buth, Juliane ; Esposito, Irene ; Berger, Johannes ; Tögel, Lars ; Saalfeld, Felix ; Wermke, Martin ; Merkelbach-Bruse, Sabine ; Hillmer, Axel Maximilian ; Klauschen, Frederick ; Bokemeyer, Carsten ; Büttner, Reinhard ; Wolf, Jürgen ; Loges, Sonja
Background: Atypical EGFR mutations occur in 10%-30% of non-small-cell lung cancer (NSCLC) patients with EGFR mutations and their sensitivity to classical epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKI) is highly heterogeneous. Patients harboring one group of uncommon, recurrent EGFR mutations (G719X, S768I, L861Q) respond to EGFR-TKI. Exon 20 insertions are mostly insensitive to EGFR-TKI but display sensitivity to exon 20 inhibitors. Clinical outcome data of patients with very rare point and compound mutations upon systemic treatments are still sparse to date.
Patients and methods: In this retrospective, multicenter study of the national Network Genomic Medicine (nNGM) in Germany, 856 NSCLC cases with atypical EGFR mutations including co-occurring mutations were reported from 12 centers. Clinical follow-up data after treatment with different EGFR-TKIs, chemotherapy and immune checkpoint inhibitors were available from 260 patients. Response to treatment was analyzed in three major groups: (i) uncommon mutations (G719X, S7681, L861Q and combinations), (ii) exon 20 insertions and (iii) very rare EGFR mutations (very rare single point mutations, compound mutations, exon 18 deletions, exon 19 insertions).
Results: Our study comprises the largest thus far reported real-world cohort of very rare EGFR single point and compound mutations treated with different systemic treatments. We validated higher efficacy of EGFR-TKI in comparison to chemotherapy in group 1 (uncommon), while most exon 20 insertions (group 2) were not EGFR-TKI responsive. In addition, we found TKI sensitivity of very rare point mutations (group 3) and of complex EGFR mutations containing exon 19 deletions or L858R mutations independent of the combination partner. Notably, treatment responses in group 3 (very rare) were highly heterogeneous. Co-occurring TP53 mutations exerted a non-significant trend for a detrimental effect on outcome in EGFR-TKI-treated patients in groups 2 and 3 but not in group 1.
Conclusions: Based on our findings, we propose a novel nNGM classification of atypical EGFR mutations.
Gecht, Judith ; Tsoukakis, Ioannis ; Kricheldorf, Kim ; Stegelmann, Frank ; Klausmann, Martine ; Griesshammer, Martin ; Schulz, Holger ; Hollburg, Wiebke ; Göthert, Joachim Rudolf ; Sockel, Katja ; Heidel, Florian ; Gattermann, Norbert ; Maintz, Christoph ; Al-Ali, Haifa Kathrin ; Platzbecker, Uwe ; Hansen, Richard ; Hänel, Mathias ; Parmentier, Stefani Barbara ; Bommer, Martin ; Pahl, Heike L. ; Lang, Fabian Magnus Eugen ; Kirschner, Martin ; Isfort, Susanne ; Brümmendorf, Tim Henrik ; Döhner, Konstanze ; Koschmieder, Steffen
Simple Summary: In patients with myeloproliferative neoplasms (MPN) and in patients with kidney dysfunction, a higher rate of thrombosis has been reported compared with the general population. Furthermore, MPN patients are more prone to develop kidney dysfunction. In our study, we assessed the importance of specific risk factors for kidney dysfunction and thrombosis in MPN patients. We found that the rate of thrombosis is correlated with the degree of kidney dysfunction, especially in myelofibrosis. Significant associations for kidney dysfunction included arterial hypertension, MPN treatment, and increased inflammation, and those for thrombosis comprised arterial hypertension, non-excessive platelet counts, and antithrombotic therapy. The identified risk factor associations varied between MPN subtypes. Our data suggest that kidney dysfunction in MPN patients is associated with an increased risk of thrombosis, mandating closer monitoring, and, possibly, early thromboprophylaxis.
Abstract: Inflammation-induced thrombosis represents a severe complication in patients with myeloproliferative neoplasms (MPN) and in those with kidney dysfunction. Overlapping disease-specific attributes suggest common mechanisms involved in MPN pathogenesis, kidney dysfunction, and thrombosis. Data from 1420 patients with essential thrombocythemia (ET, 33.7%), polycythemia vera (PV, 38.5%), and myelofibrosis (MF, 27.9%) were extracted from the bioregistry of the German Study Group for MPN. The total cohort was subdivided according to the calculated estimated glomerular filtration rate (eGFR, (mL/min/1.73 m2)) into eGFR1 (≥90, 21%), eGFR2 (60–89, 56%), and eGFR3 (<60, 22%). A total of 29% of the patients had a history of thrombosis. A higher rate of thrombosis and longer MPN duration was observed in eGFR3 than in eGFR2 and eGFR1. Kidney dysfunction occurred earlier in ET than in PV or MF. Multiple logistic regression analysis identified arterial hypertension, MPN treatment, increased uric acid, and lactate dehydrogenase levels as risk factors for kidney dysfunction in MPN patients. Risk factors for thrombosis included arterial hypertension, non-excessive platelet counts, and antithrombotic therapy. The risk factors for kidney dysfunction and thrombosis varied between MPN subtypes. Physicians should be aware of the increased risk for kidney disease in MPN patients, which warrants closer monitoring and, possibly, early thromboprophylaxis.
Ackermann, K. H. ; Adams, N. ; Adler, Clemens ; Ahammed, Zubayer ; Ahmad, Shakeel ; Allgower, Chris ; Amsbaugh, J. ; Anderson, Mike ; Anderssen, E. ; Arnesen, H. ; Arnold, L. ; Averichev, Georgy S. ; Baldwin, A. ; Balewski, Jan ; Barannikova, Olga ; Barnby, Lee Stuart ; Baudot, Jérome ; Beddo, M. ; Bekele, Selemon ; Belaga, Victoria Vladimirovna ; Bellwied, Rene ; Bennett, Samuel ; Bercovitz, J. ; Berger, Jens ; Betts, W. ; Bichsel, Hans ; Bieser, F. ; Bland, Leslie C. ; Bloomer, Matthew A. ; Blyth, Charles O. ; Boehm, J. ; Bonner, Billy E. ; Bonnet, D. ; Bossingham, R. ; Botlo, M. ; Boucham, Abdelkrim ; Bouillo, N. ; Bouvier, S. ; Bradley, K. ; Brady, Franklin Paul ; Braithwaite, E. S. ; Braithwaite, Wilfred J. ; Brandin, Andrei V. ; Brown, R. L. ; Brugalette, G. ; Byrd, C. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cardenas, Andrés ; Carr, Lincoln D. ; Carroll, J. ; Castillo Castellanos, Javier Ernesto ; Caylor, B. ; Cebra, Daniel A. ; Chatopadhyay, S. ; Chen, M. L. ; Chen, W. ; Chen, Y. ; Chernenko, Sergey P. ; Cherney, Michael Gerard ; Chikanian, Alexei ; Choi, B. ; Chrin, J. ; Christie, William ; Coffin, Jean Pierre ; Conin, L. ; Consiglio, C. ; Cormier, Thomas Michael ; Cramer, John G. ; Crawford, Henry J. ; Danilov, V. I. ; Dayton, D. ; DeMello, M. ; Deng, W. S. ; Derevschikov, Anatoly A. ; Dialinas, M. ; Diaz, H. ; DeYoung, P. A. ; Didenko, Lidia ; Dimassimo, D. ; Dioguardi, J. ; Dominik, W. ; Drancourt, C. ; Draper, James E. ; Dunin, V. B. ; Dunlop, James C. ; Eckardt, Volker ; Edwards, W. R. ; Efimov, Leonid G. ; Eggert, T. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, Barbara Ewa ; Etkin, A. ; Fachini, Patricia ; Feliciano, C. ; Ferenc, D. ; Ferguson, M. I. ; Fessler, H. ; Finch, Evan ; Fine, Valeri ; Fisyak, Yuri V. ; Flierl, Dominik Bernhard ; Flores, I. ; Foley, Kenneth John ; Fritz, D. ; Gagunashvili, N. ; Gans, J. ; Gaździcki, Marek ; Germain, Marie ; Geurts, Frank ; Ghazikhanian, Vahe ; Gojak, C. ; Grabski, J. ; Grachov, Oleg A. ; Grau, M. ; Greiner, D. ; Greiner, Leo Clifford ; Grigoriev, Vladislav A. ; Grosnick, David P. ; Gross, J. ; Guilloux, G. ; Gushin, E. ; Hall, J. ; Hallman, Timothy J. ; Hardtke, David H. ; Harper, G. ; Harris, John W. ; He, P. ; Heffner, M. ; Heppelmann, S. ; Herston, T. ; Hill, D. ; Hippolyte, Boris ; Hirsch, Andrew S. ; Hjort, Eric ; Hoffmann, Gerald W. ; Horsley, M. ; Howe, Mark A. ; Huang, Huan Zhong ; Humanic, Thomas J. ; Hümmler, H. ; Hunt, W. ; Hunter, J. ; Igo, George J. ; Ishihara, A. ; Ivanshin, Yu. I. ; Jacobs, P. ; Jacobs, William W. ; Jacobson, S. ; Jared, R. ; Jensen, P. ; Johnson, I. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kaneta, Kaneta ; Kaplan, Morton ; Keane, Declan ; Kenney, V. P. ; Khodinov, A. ; Klay, Jennifer Lynn ; Klein, Spencer Robert ; Klyachko, A. ; Koehler, G. ; Konstantinov, A. S. ; Kormilitsyne, V. ; Kotchenda, L. ; Kotov, I. ; Kovalenko, A. D. ; Kramer, M. ; Kravtsov, Peter ; Krueger, Keith William ; Krupien, T. ; Kuczewski, P. ; Kuhn, Christian Claude ; Kunde, Gerd J. ; Kunz, Christopher Lee ; Kutuev, R. Kh. ; Kuznetsov, A. A. ; Lakehal-Ayat, L. ; Lamas-Valverde, Jose ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Lansdell, Curtis Patrick Leon ; Lasiuk, Brian ; Laue, Frank ; Lebedev, Alexei ; LeCompte, T. ; Leonhardt, W. J. ; Leontiev, V. M. ; Leszczynski, P. ; LeVine, Micheal J. ; Li, Q. ; Li, Q. ; Li, Z. ; Liaw, C.-J. ; Lin, J. ; Lindenbaum, Sam J. ; Lindenstruth, Volker ; Lindstrom, P. J. ; Lisa, Michael A. ; Liu, H. ; Ljubicic, Tonko A. ; Llope, William Joseph ; LoCurto, G. ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Lopiano, D. ; Love, William A. ; Lutz, J. R. ; Lynn, David ; Madansky, L. ; Maier, R. ; Majka, Richard Daniel ; Maliszewski, A. ; Margetis, Spyridon ; Marks, K. ; Marstaller, R. ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yuri A. ; Matyushevski, E. A. ; McParland, C. ; McShane, Tom S. ; Meier, J. ; Melnick, Yu. ; Meščanin, Aleksei P. ; Middlekamp, P. ; Mikhalin, N. ; Miller, B. ; Milosevich, Z. ; Minaev, Nikolai G. ; Minor, B. ; Mitchell, J. ; Mogavero, E. ; Moiseenko, V. A. ; Moltz, D. ; Moore, C. F. ; Morozov, V. ; Morse, R. ; de Moura, M. M. ; Munhoz, Marcelo Gameiro ; Mutchler, G. S. ; Nelson, John M. ; Nevski, P. ; Ngo, T. ; Nguyen, M. ; Nguyen, T. ; Nikitin, Vladimir A. ; Nogach, Larisa V. ; Noggle, T. ; Norman, B. ; Nurušev, Sandibek B. ; Nussbaum, T. ; Nystrand, Joakim Ingemar ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Ogilvie, C. A. ; Olchanski, K. ; Oldenburg, Markus D. ; Olson, Douglas L. ; Ososkov, G. A. ; Ott, G. ; Padrazo, D. ; Paic, Guy ; Pandey, S. U. ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, Alexei I. ; Pawlak, Tomasz Jan ; Pentia, M. ; Perevotchikov, V. ; Peryt, Wiktor Stanislaw ; Petrov, V. A ; Pinganaud, W. ; Pirogov, S. ; Platner, E. ; Pluta, Jan Marian ; Polk, I. ; Porile, Norbert T. ; Porter, Jeffrey Brent ; Poskanzer, Arthur M. ; Potrebenikova, E. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Puskar-Pasewicz, J. ; Rai, Gulshan ; Rasson, J. ; Ravel, Olivier ; Ray, Robert L. ; Razin, Sergej V. ; Reichhold, Dennis Michael ; Reid, J. ; Renfordt, Rainer Arno Ernst ; Retiere, Fabrice ; Ridiger, Alexey ; Riso, J. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Röhrich, Dieter ; Rogachevski, O. V. ; Romero, Juan L. ; Roy, Christelle Sophie ; Russ, D. ; Rykov, Vladimir L. ; Sakrejda, Iwona ; Sanchez, R. ; Sandler, Z. ; Sandweiss, Jack H. ; Sappenfield, P. ; Saulys, A. C. ; Savin, Igor A. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Scheblien, J. ; Scheetz, R. ; Schlueter, R. ; Schmitz, Norbert ; Schroeder, Lee S. ; Schulz, M. ; Schüttauf, Andreas ; Sedlmeir, J. ; Seger, Janet Elizabeth ; Seliverstov, D. ; Seyboth, J. ; Seyboth, Peter ; Seymour, R. ; Shakaliev, E. I. ; Shestermanov, Konstantin E. ; Shi, Y. ; Šimanskij, Stepan S. ; Shuman, D. ; Shvetcov, V. S. ; Skoro, Goran P. ; Smirnov, N. ; Smykov, L. P. ; Snellings, Raimond ; Solberg, K. ; Sowinski, James ; Spinka, Harold. M. ; Srivastava, B. ; Stephenson, Edward J. ; Stock, Reinhard ; Stolpovsky, Alexander ; Stone, N. ; Stone, R. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Stroebele, H. ; Struck, Christof ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, Evan R. ; Suire, Christophe Pierre ; Symons, Timothy James MacNeil ; Takahashi, Jun ; Tang, Aihong ; Tarchini, A. ; Tarzian, J. ; Thomas, James H. ; Tikhomirov, V. ; Toledo, Alejandro Szanto de ; Tonse, S. ; Trainor, Thomas A. ; Trentalange, Stephen ; Tokarev, Mikhail V. ; Tonjes, Marguerite Belt ; Trofimov, V. ; Tsai, Oleg D. ; Turner, K. ; Ullrich, Thomas ; Underwood, David G. ; Vakula, I. ; Van Buren, Gene ; VanderMolen, A. M. ; Vanyashin, A. ; Vasilevski, I. M. ; Vasiliev, Alexander Nikolaevich ; Vigdor, Steven E. ; Visser, G. ; Voloshin, Sergei ; Vu, C. ; Wang, F. ; Ward, H. ; Weerasundara, Dhammika D. ; Weidenbach, R. ; Wells, R. ; Wells, R. ; Wenaus, T. ; Westfall, Gary D. ; Whitfield, J. P. ; Whitten, Charles A. ; Wieman, Howard ; Willson, Robert ; Wilson, K. ; Wirth, Joana ; Wisdom, J. ; Wissink, Scott W. ; Witt, Richard ; Wolf, J. ; Wood, L. ; Xu, N. ; Xu, Z. ; Yakutin, A. E. ; Yamamoto, E. ; Yang, J. ; Yepes, Pablo P. ; Yokosawa, A. ; Yurevich, Vladimir Yurevich ; Zanevski, Y. V. ; Zhang, J. ; Zhang, W. M. ; Zhu, Jianhui ; Zimmerman, D. ; Zoulkarneev, R. ; Zubarev, A. N.
Elliptic flow from nuclear collisions is a hadronic observable sensitive to the early stages of system evolution. We report first results on elliptic flow of charged particles at midrapidity in Au+Au collisions at sqrt(s_NN)=130 GeV using the STAR TPC at RHIC. The elliptic flow signal, v_2, averaged over transverse momentum, reaches values of about 6% for relatively peripheral collisions and decreases for the more central collisions. This can be interpreted as the observation of a higher degree of thermalization than at lower collision energies. Pseudorapidity and transverse momentum dependence of elliptic flow are also presented.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, G. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, I. ; Anderson, D. M. ; Aparin, A. ; Aschenauer, Elke Caroline ; Ashraf, M. U. ; Atetalla, F. G. ; Attri, A. ; Averichev, G. S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, A. ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, I. G. ; Brandenburg, James D. ; Brandin, A. V. ; Bunzarov, I. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B. K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J. H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovich, T. G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Elsey, N. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F. M. ; Fazio, Salvatore ; Federic, P. ; Fedorisin, J. ; Feng, C. J. ; Feng, Yicheng ; Filip, P. ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, A. ; Fu, C. ; Fulek, L. ; Gagliardi, Carl A. ; Galatyuk, T. ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, A. I. ; Hamed, Ahmed M. ; Han, Yiding ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison, Hannah ; He, S. ; He, W. ; He, Xionghong ; He, Y. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Igo, G. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M. L. ; Kagamaster, S. ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, H. W. ; Keane, Declan ; Kechechyan, A. ; Kelsey, M. ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H. S. ; Kochenda, L. ; Kosarzewski, Leszek Krzysztof ; Kramarik, L. ; Kravtsov, P. ; Kumar, Lokesh ; Kumar, S. ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, J. H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, A. ; Lednicky, R. ; Lee, J. H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, Tong ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, W. J. ; Longacre, Ronald S. ; Loyd, E. ; Lukow, N. S. ; Luo, X. F. ; Ma, L. ; Ma, R. ; Ma, Y. G. ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, D. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, J. A. ; Minaev, N. G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, D. A. ; Mukherjee, A. ; Nagy, M. ; Nam, J. D. ; Nasim, Md. ; Nayak, K. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, L. V. ; Nonaka, Toshihiro ; Nunes, A. S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pan, J. ; Pandav, Ashish ; Pandey, A. K. ; Panebratsev, Yuri ; Parfenov, P. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pinsky, L. ; Pluta, Jan Marian ; Pokhrel, B. R. ; Ponimatkin, G. ; Porter, J. ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, Monika ; Rogachevskiy, O. V. ; Romero, J. L. ; Roy, D. ; Ruan, L. ; Rusnak, J. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, J. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, B. R. ; Seck, F. ; Seger, Janet Elizabeth ; Sergeeva, M. ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, E. ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, Tianhao ; Sheikh, Ashik Ikbal ; Shen, D. Y. ; Shi, Shusu ; Shi, Y. ; Shou, Q. Y. ; Sichtermann, E. P. ; Sikora, R. ; Simko, M. ; Singh, J. ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, N. ; Söhngen, Yannick ; Solyst, W. ; Song, Y. ; Sorensen, P. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. S. ; Stefaniak, Maria ; Stewart, David J. ; Strikhanov, M. ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, B. ; Sun, X. M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, D. N. ; Sweger, Zachary W. ; Szymanski, P. ; Tang, Aihong ; Tang, Zebo ; Taranenko, A. ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, C. A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, A. N. ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, S. ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J. S. ; Wang, P. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z. J. ; Zhang, Z. ; Zhang, Z. ; Zhao, J. ; Zhou, C. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, G. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, I. ; Anderson, D. M. ; Aparin, A. ; Aschenauer, Elke Caroline ; Ashraf, M. U. ; Atetalla, F. G. ; Attri, A. ; Averichev, G. S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, A. ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, I. G. ; Brandenburg, James D. ; Brandin, A. V. ; Bunzarov, I. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B. K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J. H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovich, T. G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Elsey, N. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F. M. ; Fazio, Salvatore ; Federic, P. ; Fedorisin, J. ; Feng, C. J. ; Feng, Yicheng ; Filip, P. ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, A. ; Fu, C. ; Fulek, L. ; Gagliardi, Carl A. ; Galatyuk, T. ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, A. I. ; Hamed, Ahmed M. ; Han, Yiding ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison, Hannah ; He, S. ; He, W. ; He, Xionghong ; He, Y. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Igo, G. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M. L. ; Kagamaster, S. ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, H. W. ; Keane, Declan ; Kechechyan, A. ; Kelsey, M. ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H. S. ; Kochenda, L. ; Kosarzewski, Leszek Krzysztof ; Kramarik, L. ; Kravtsov, P. ; Kumar, Lokesh ; Kumar, S. ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, J. H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, A. ; Lednicky, R. ; Lee, J. H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, Tong ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, W. J. ; Longacre, Ronald S. ; Loyd, E. ; Lukow, N. S. ; Luo, X. F. ; Ma, L. ; Ma, R. ; Ma, Y. G. ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, D. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, J. A. ; Minaev, N. G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, D. A. ; Mukherjee, A. ; Nagy, M. ; Nam, J. D. ; Nasim, Md. ; Nayak, K. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, L. V. ; Nonaka, Toshihiro ; Nunes, A. S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pan, J. ; Pandav, Ashish ; Pandey, A. K. ; Panebratsev, Yuri ; Parfenov, P. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pinsky, L. ; Pluta, Jan Marian ; Pokhrel, B. R. ; Ponimatkin, G. ; Porter, J. ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, Monika ; Rogachevskiy, O. V. ; Romero, J. L. ; Roy, D. ; Ruan, L. ; Rusnak, J. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, J. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, B. R. ; Seck, F. ; Seger, Janet Elizabeth ; Sergeeva, M. ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, E. ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, Tianhao ; Sheikh, Ashik Ikbal ; Shen, D. Y. ; Shi, Shusu ; Shi, Y. ; Shou, Q. Y. ; Sichtermann, E. P. ; Sikora, R. ; Simko, M. ; Singh, J. ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, N. ; Söhngen, Yannick ; Solyst, W. ; Song, Y. ; Sorensen, P. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. S. ; Stefaniak, Maria ; Stewart, David J. ; Strikhanov, M. ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, B. ; Sun, X. M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, D. N. ; Sweger, Zachary W. ; Szymanski, P. ; Tang, Aihong ; Tang, Zebo ; Taranenko, A. ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, C. A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, A. N. ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, S. ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J. S. ; Wang, P. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z. J. ; Zhang, Z. ; Zhang, Z. ; Zhao, J. ; Zhou, C. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
Abdallah, Mohamed Samy ; Aboona, Bassam ; Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, G. ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, I. ; Anderson, D. M. ; Aparin, A. ; Aschenauer, Elke Caroline ; Ashraf, M. U. ; Atetalla, F. G. ; Attri, A. ; Averichev, G. S. ; Bairathi, Vipul ; Baker, W. ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Behera, A. ; Bellwied, Rene ; Bhagat, Pratibha ; Bhasin, Anju ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bordyuzhin, I. G. ; Brandenburg, James D. ; Brandin, A. V. ; Bunzarov, I. ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, B. K. ; Chang, F-H. ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, D. ; Chen, J. ; Chen, J. H. ; Chen, X. ; Chen, Z. ; Cheng, J. ; Chevalier, M. ; Choudhury, Subikash ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Csanád, Máté ; Daugherity, M. ; Dedovich, T. G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Dhamija, A. ; Di Carlo, L. ; Didenko, Lidia ; Dixit, Prabhupada ; Dong, X. ; Drachenberg, James Lucus ; Duckworth, Emilie ; Dunlop, James C. ; Elsey, N. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, A. ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fawzi, F. M. ; Fazio, Salvatore ; Federic, P. ; Fedorisin, J. ; Feng, C. J. ; Feng, Yicheng ; Filip, P. ; Finch, Evan ; Fisyak, Yuri V. ; Francisco, A. ; Fu, C. ; Fulek, L. ; Gagliardi, Carl A. ; Galatyuk, T. ; Geurts, Frank ; Ghimire, Navagyan ; Gibson, Adam ; Gopal, Krishan ; Gou, X. ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, A. I. ; Hamed, Ahmed M. ; Han, Yiding ; Harabasz, Szymon ; Harasty, Matthew D. ; Harris, John W. ; Harrison, Hannah ; He, S. ; He, W. ; He, Xionghong ; He, Y. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hoffman, E. ; Holub, Lukáš ; Hu, Y. ; Huang, H. ; Huang, Huan Zhong ; Huang, Shengli ; Huang, T. ; Huang, X. ; Huang, Y. ; Humanic, Thomas J. ; Igo, G. ; Isenhower, D. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, K. ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kabir, M. L. ; Kagamaster, S. ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, H. W. ; Keane, Declan ; Kechechyan, A. ; Kelsey, M. ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, C. ; Kimelman, B. ; Kincses, D. ; Kisel, Ivan ; Kiselev, A. ; Knospe, Anders Garritt ; Ko, H. S. ; Kochenda, L. ; Kosarzewski, Leszek Krzysztof ; Kramarik, L. ; Kravtsov, P. ; Kumar, Lokesh ; Kumar, S. ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, J. H. ; Lacey, Roy Alphanso ; Lan, Shaowei ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, A. ; Lednicky, R. ; Lee, J. H. ; Leung, Yue Hang ; Lewis, N. ; Li, C. ; Li, C. ; Li, W. ; Li, X. ; Li, Y. ; Liang, X. ; Liang, Y. ; Licenik, Robert ; Lin, T. ; Lin, Y. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, H. ; Liu, P. ; Liu, Tong ; Liu, X. ; Liu, Y. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, W. J. ; Longacre, Ronald S. ; Loyd, E. ; Lukow, N. S. ; Luo, X. F. ; Ma, L. ; Ma, R. ; Ma, Y. G. ; Magdy Abdelwahab Abdelrahman, Niseem ; Mallick, D. ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mazer, J. A. ; Minaev, N. G. ; Mioduszewski, Saskia ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Morozov, D. A. ; Mukherjee, A. ; Nagy, M. ; Nam, J. D. ; Nasim, Md. ; Nayak, K. ; Neff, D. ; Nelson, John M. ; Nemes, Daniel B. ; Nie, M. ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nishitani, R. ; Nogach, L. V. ; Nonaka, Toshihiro ; Nunes, A. S. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Pan, J. ; Pandav, Ashish ; Pandey, A. K. ; Panebratsev, Yuri ; Parfenov, P. ; Pawlik, Bogdan ; Pawłowska, Diana ; Perkins, Chris ; Pinsky, L. ; Pluta, Jan Marian ; Pokhrel, B. R. ; Ponimatkin, G. ; Porter, J. ; Posik, Matthew ; Prozorova, V. ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Qiu, H. ; Quintero, Amilkar ; Racz, Cameron ; Radhakrishnan, Sooraj Krishnan ; Raha, N. ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Robotkova, Monika ; Rogachevskiy, O. V. ; Romero, J. L. ; Roy, D. ; Ruan, L. ; Rusnak, J. ; Sahoo, Aswini Kumar ; Sahoo, Nihar Ranjan ; Sako, H. ; Salur, Sevil ; Sandweiss, J. ; Sato, Susumu ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, B. R. ; Seck, F. ; Seger, Janet Elizabeth ; Sergeeva, M. ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, E. ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shao, Tianhao ; Sheikh, Ashik Ikbal ; Shen, D. Y. ; Shi, Shusu ; Shi, Y. ; Shou, Q. Y. ; Sichtermann, E. P. ; Sikora, R. ; Simko, M. ; Singh, J. ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, N. ; Söhngen, Yannick ; Solyst, W. ; Song, Y. ; Sorensen, P. ; Spinka, Harold. M. ; Srivastava, B. ; Stanislaus, T. D. S. ; Stefaniak, Maria ; Stewart, David J. ; Strikhanov, M. ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Šumbera, Michal ; Summa, B. ; Sun, X. M. ; Sun, X. ; Sun, Y. ; Sun, Y. ; Surrow, Bernd ; Svirida, D. N. ; Sweger, Zachary W. ; Szymanski, P. ; Tang, Aihong ; Tang, Zebo ; Taranenko, A. ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, C. A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Truhlar, Tomas ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, A. N. ; Vassiliev, Iouri ; Verkest, Veronica ; Videbæk, Flemming ; Vokal, S. ; Voloshin, Sergei ; Wang, F. ; Wang, G. ; Wang, J. S. ; Wang, P. ; Wang, X. ; Wang, Y. ; Wang, Y. ; Wang, Z. ; Webb, Jason C. ; Weidenkaff, Philipp ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, J. ; Wu, J. ; Wu, Y. ; Xi, B. ; Xiao, Z. G. ; Xie, Guannan ; Xie, W. ; Xu, H. ; Xu, N. ; Xu, Qinghua ; Xu, Y. ; Xu, Z. ; Xu, Z. ; Yan, G. ; Yang, C. ; Yang, Q. ; Yang, S. ; Yang, Y. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yu, Y. ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, C. ; Zhang, Dingwei ; Zhang, J. ; Zhang, S. ; Zhang, S. ; Zhang, X. P. ; Zhang, Y. ; Zhang, Y. ; Zhang, Y. ; Zhang, Z. J. ; Zhang, Z. ; Zhang, Z. ; Zhao, J. ; Zhou, C. ; Zhou, Y. ; Zhu, X. ; Żurek, Maria Katarzyna ; Zyzak, Maksym
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at sNN−−−√ = 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
Adams, Joseph R. ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Amonett, J. ; Anderson, B.D. ; Arkhipkin, D. ; Averichev, Georgy S. ; Badyal, S.K. ; Bai, Yu ; Balewski, J. ; Barannikova, O. ; Barnby, L.S. ; Baudot, J. ; Bekele, S. ; Belaga, V.V. ; Bellingeri-Laurikainen, A. ; Bellwied, Rene ; Berger, J. ; Bezverkhny, B.I. ; Bharadwaj, S. ; Bhasin, A. ; Bhati, A.K. ; Bhatia, V.S. ; Bichsel, Hans ; Bielcik, J. ; Bielcikova, Jana ; Billmeier, A. ; Bland, L.C. ; Blyth, C.O. ; Blyth, S.-L. ; Bonner, B.E. ; Botje, M. ; Boucham, A. ; Bouchet, J. ; Brandin, A.V. ; Bravar, A. ; Bystersky, M. ; Cadman, R.V. ; Cai, X.Z. ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Castillo Castellanos, Javier Ernesto ; Catu, O. ; Cebra, D. ; Chajecki, Z. ; Chaloupka, Petr ; Chattopadhyay, S. ; Chen, H.F. ; Chen, J.H. ; Chen, Y. ; Cheng, J. ; Cherney, M. ; Chikanian, A. ; Choi, H.A. ; Christie, William ; Coffin, J.P. ; Cormier, Thomas Michael ; Cosentino, M.R. ; Cramer, J.G. ; Crawford, Henry J. ; Das, D. ; Das, S. ; Daugherity, M. ; de Moura, M.M. ; Dedovich, T.G. ; DePhillips, M. ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dietel, Thomas ; Dogra, S.M. ; Dong, W.J. ; Dong, X. ; Draper, J.E. ; Du, F. ; Dubey, A.K. ; Dunin, V.B. ; Dunlop, James C. ; Dutta Mazumdar, M.R. ; Eckardt, V. ; Edwards, W.R. ; Efimov, L.G. ; Emelianov, V. ; Engelage, Jon M. ; Eppley, Geary Wareham ; Erazmus, B. ; Estienne, M. ; Fachini, P. ; Faivre, J. ; Fatemi, Renee H. ; Fedorisin, J. ; Filimonov, K. ; Filip, P. ; Finch, Evan ; Fine, V. ; Fisyak, Yuri V. ; Fornazier, K.S.F. ; Fu, J. ; Gagliardi, Carl A. ; Gaillard, L. ; Gans, J. ; Ganti, M.S. ; Geurts, Frank ; Ghazikhanian, V. ; Ghosh, P. ; Gonzalez, Johan Enmanuel ; Gos, H. ; Grachov, O. ; Grebenyuk, O. ; Grosnick, David P. ; Guertin, S.M. ; Guo, Y. ; Gupta, Anik ; Gupta, N. ; Gutierrez, T.D. ; Hallman, T.J. ; Hamed, Ahmed M. ; Hardtke, D. ; Harris, John W. ; Heinz, M. ; Henry, T.W. ; Hepplemann, S. ; Hippolyte, Boris ; Hirsch, A. ; Hjort, E. ; Hoffmann, Gerald W. ; Horner, M.J. ; Huang, Huan Zhong ; Huang, Shengli ; Hughes, E.W. ; Humanic, Thomas J. ; Igo, G. ; Ishihara, A. ; Jacobs, P. ; Jacobs, William W. ; Jedynak, M. ; Jiang, H. ; Jones, Peter Graham ; Judd, Eleanor G. ; Kabana, Sonia ; Kang, K. ; Kaplan, M. ; Keane, Declan ; Kechechyan, A. ; Khodyrev, V.Yu. ; Kim, B.C. ; Kiryluk, J. ; Kisiel, A. ; Kislov, E.M. ; Klay, J. ; Klein, S.R. ; Koetke, D.D. ; Kollegger, Thorsten ; Kopytine, M. ; Kotchenda, L. ; Kowalik, K.L. ; Kramer, M. ; Kravtsov, P. ; Kravtsov, V.I. ; Krueger, Keith William ; Kuhn, C. ; Kulikov, A.I. ; Kumar, A. ; Kutuev, R.Kh. ; Kuznetsov, A.A. ; Lamont, Matthew A. C. ; Landgraf, Jeffery M. ; Lange, S. ; Laue, F. ; Lauret, Jerome ; Lebedev, A. ; Lednicky, R. ; Lee, C.-H. ; Lehocka, S. ; LeVine, M.J. ; Li, C. ; Li, Q. ; Li, Y. ; Lin, G. ; Lindenbaum, S.J. ; Lisa, Michael A. ; Liu, F. ; Liu, H. ; Liu, J. ; Liu, L. ; Liu, Q.J. ; Liu, Z. ; Ljubicic, Tonko A. ; Llope, W.J. ; Long, H. ; Longacre, Ronald S. ; Lopez-Noriega, M. ; Love, W.A. ; Lu, Y. ; Ludlam, Thomas ; Lynn, D. ; Ma, G.L. ; Ma, J.G. ; Ma, Y.G. ; Magestro, D. ; Mahajan, Sanjay ; Mahapatra, Durga Prasad ; Majka, R. ; Mangotra, L.K. ; Manweiler, R. ; Margetis, Spyridon ; Markert, Christina ; Martin, L. ; Marx, Jay N. ; Matis, Howard S. ; Matulenko, Yu.A. ; McClain, C.J. ; McShane, T.S. ; Meissner, F. ; Melnick, Yu. ; Meschanin, A. ; Miller, M.L. ; Minaev, N.G. ; Mironov, C. ; Mischke, A. ; Mishra, D.K. ; Mitchell, J. ; Mohanty, Bedangadas ; Molnar, L. ; Moore, C.F. ; Morozov, D.A. ; Munhoz, M.G. ; Nandi, B.K. ; Nayak, S.K. ; Nayak, T.K. ; Nelson, John M. ; Netrakanti, P.K. ; Nikitin, V.A. ; Nogach, L.V. ; Nurushev, S.B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Okorokov, Vitaly A. ; Oldenburg, Markus D. ; Olson, D. ; Pal, S.K. ; Panebratsev, Yuri ; Panitkin, Sergei Yurievich ; Pavlinov, A.I. ; Pawlak, T. ; Peitzmann, Thomas ; Perevoztchikov, V. ; Perkins, Chris ; Peryt, W. ; Petrov, V.A. ; Phatak, S.C. ; Picha, R. ; Planinic, Mirko ; Pluta, Jan Marian ; Porile, Norbert T. ; Porter, J. ; Poskanzer, Arthur M. ; Potekhin, M. ; Potrebenikova, E. ; Potukuchi, B.V.K.S. ; Prindle, Duncan J. ; Pruneau, Claude A. ; Putschke, Jörn H. ; Rakness, G. ; Raniwala, R. ; Raniwala, S. ; Ravel, O. ; Ray, Robert L. ; Razin, S.V. ; Reichhold, D. ; Reid, Jeffrey G. ; Reinnarth, J. ; Renault, G. ; Retiere, F. ; Ridiger, A. ; Ritter, Hans Georg ; Roberts, J.B. ; Rogachevskiy, O.V. ; Romero, J.L. ; Rose, A. ; Roy, C. ; Ruan, L. ; Russcher, M.J. ; Sahoo, R. ; Sakrejda, I. ; Salur, Sevil ; Sandweiss, J. ; Sarsour, M. ; Savin, I. ; Sazhin, P.S. ; Schambach, Joachim ; Scharenberg, Rolf Paul ; Schmitz, Norbert ; Schweda, Kai ; Seger, J. ; Seyboth, P. ; Shahaliev, E. ; Shao, M. ; Shao, W. ; Sharma, M. ; Shen, W.Q. ; Shestermanov, K.E. ; Shimanskiy, S.S. ; Sichtermann, E. ; Simon, F. ; Singaraju, R.N. ; Smirnov, Nikolai ; Snellings, Raimond ; Sood, G. ; Sorensen, P. ; Sowinski, James ; Speltz, J. ; Spinka, Harold. M. ; Srivastava, B. ; Stadnik, A. ; Stanislaus, T.D.S. ; Stock, Reinhard ; Stolpovsky, A. ; Strikhanov, M. ; Stringfellow, B. ; Suaide, Alexandre Alarcon do Passo ; Sugarbaker, E. ; Šumbera, Michal ; Surrow, Bernd ; Swanger, M. ; Symons, T.J.M. ; Szanto de Toledo, A. ; Tai, A. ; Takahashi, Jun ; Tang, Aihong ; Tarnowsky, Terence J. ; Thein, D. ; Thomas, James H. ; Timmins, Anthony Robert ; Timoshenko, S. ; Tokarev, M. ; Trainor, T.A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tsai, Oleg D. ; Ulery, J. ; Ullrich, Thomas ; Underwood, David G. ; Van Buren, Gene ; Kolk, Naomi van der ; Leeuwen, Marco van ; Vander Molen, A.M. ; Varma, R. ; Vasilevski, I.M. ; Vasiliev, A.N. ; Vernet, R. ; Vigdor, S.E. ; Viyogi, Y.P. ; Vokal, S. ; Voloshin, Sergei ; Waggoner, W.T. ; Wang, F. ; Wang, G. ; Wang, G. ; Wang, X.L. ; Wang, Y. ; Wang, Y. ; Wang, Z.M. ; Ward, H. ; Watson, J.W. ; Webb, J.C. ; Westfall, Gary D. ; Wetzler, Alexander Albert ; Whitten, Charles A. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wood, J. ; Wu, J. ; Xu, N. ; Xu, Z. ; Xu, Z.Z. ; Yamamoto, E. ; Yepes, P. ; Yoo, I.-K. ; Yurevich, V.I. ; Zborovsky, I. ; Zhang, H. ; Zhang, W.M. ; Zhang, Y. ; Zhang, Z.P. ; Zhong, C. ; Zoulkarneev, R. ; Zoulkarneeva, Youlia ; Zubarev, A.N. ; Zuo, J.X.
We present the first measurements of charge-dependent correlations on angular difference variables η1 − η2 (pseudorapidity) and φ1 − φ2 (azimuth) for primary charged hadrons with transverse momentum 0.15 <= pt <= 2 GeV/c and |η| <= 1.3 from Au–Au collisions at √sNN = 130 GeV. We observe correlation structures not predicted by theory but consistent with evolution of hadron emission geometry with increasing centrality from one-dimensional fragmentation of color strings along the beam direction to an at least two-dimensional hadronization geometry along the beam and azimuth directions of a hadron-opaque bulk medium.