Refine
Year of publication
Document Type
- Article (70)
- Contribution to a Periodical (2)
- Preprint (2)
- Conference Proceeding (1)
Has Fulltext
- yes (75)
Is part of the Bibliography
- no (75)
Keywords
- Nuclear reactions (3)
- 2-aminobenzimidazole (2)
- Radiative capture (2)
- guanidine analogs (2)
- 140Ce (1)
- Ab initio calculations (1)
- Accelerators & Beams (1)
- Accelerators & storage rings (1)
- Alkylation of RNA (1)
- Anti-kaon–nucleon physics (1)
- Antisense agents (1)
- Asymmetric Catalysis (1)
- Atomic & molecular beams (1)
- Atomic, Molecular & Optical (1)
- Beam loss (1)
- Bisamidines (1)
- Brønsted base (1)
- Catalysis (1)
- Charge-transfer collisions (1)
- Circular accelerators (1)
- Covid19-nmr (1)
- DNA conjugate (1)
- DNA recognition (1)
- DNA-LNA mixmers (1)
- DNA/LNA mixmers (1)
- Diels- Alder reaction (1)
- Direct reactions (1)
- Disulfide bond (1)
- EPR (1)
- Electromagnetic transitions (1)
- Electronic transitions (1)
- Fmoc solid phase peptide synthesis (1)
- Glutathione (1)
- High-energy neutron detection (1)
- Kaonic nuclei (1)
- Low & intermediate-energy accelerators (1)
- Low energy QCD (1)
- MACS (1)
- Models & methods for nuclear reactions (1)
- Multi-neutron detection (1)
- NMR spectroscopy (1)
- Neutron physics (1)
- Nuclear astrophysics (1)
- Nuclear physics of explosive environments (1)
- Nuclear structure & decays (1)
- Nucleon induced nuclear reactions (1)
- Organocatalysis (1)
- PELDOR (1)
- Partial wave analysis (1)
- Peptide nucleic acids (1)
- Photon counting (1)
- Plastic scintillator array (1)
- Post-Hartree-Fock methods (1)
- RNA (1)
- RNA cleavage (1)
- RNA induced silencing complex (1)
- RNA recognition (1)
- Reactions with relativistic radioactive beams (1)
- Resonance reactions (1)
- SARS-CoV-2 (1)
- Semi-empiricalcalculations (1)
- Shell model (1)
- Spectroscopic factors & electromagnetic moments (1)
- TEMPO (1)
- Wang resin (1)
- Western blot (1)
- absolute configuration (1)
- adaptor mediated recruitment (1)
- age (1)
- anthrone (1)
- argonaute protein (1)
- artificial ribonuclease (1)
- capture (1)
- cerium (1)
- children and adolescents (1)
- cleavage of large RNA molecules (1)
- cleavage site selection (1)
- cross-section (1)
- cycloaddition (1)
- dye labeling (1)
- f-MLF (1)
- formylation (1)
- fragment screening (1)
- germ cell tumors (1)
- hairpin polyamides (1)
- histology (1)
- kinetic resolution (1)
- lipase (1)
- locked nucleic acids (1)
- mRNA (1)
- magic-angle spinning (1)
- n_TOF (1)
- neutron (1)
- nucleosynthesis (1)
- oligonucleotide (1)
- oligonucleotides (1)
- ovary (1)
- photolabile protection (1)
- ppK − (1)
- protein capture (1)
- pull-down (1)
- s-process (1)
- sex (1)
- specificity of cleavage (1)
- testis (1)
- x-ray techniques (1)
Institute
- Physik (56)
- Biochemie und Chemie (9)
- ELEMENTS (9)
- Biochemie, Chemie und Pharmazie (7)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (3)
- Präsidium (2)
- Biowissenschaften (1)
- Medizin (1)
Quasifree one-proton knockout reactions have been employed in inverse kinematics for a systematic study of the structure of stable and exotic oxygen isotopes at the R3B/LAND setup with incident beam energies in the range of 300–450 MeV/u. The oxygen isotopic chain offers a large variation of separation energies that allows for a quantitative understanding of single-particle strength with changing isospin asymmetry. Quasifree knockout reactions provide a complementary approach to intermediate-energy one-nucleon removal reactions. Inclusive cross sections for quasifree knockout reactions of the type AO(p,2p)A−1N have been determined and compared to calculations based on the eikonal reaction theory. The reduction factors for the single-particle strength with respect to the independent-particle model were obtained and compared to state-of-the-art ab initio predictions. The results do not show any significant dependence on proton-neutron asymmetry.
We measured the Coulomb dissociation of 16O into 4He and 12C at the R3B setup in a first campaign within FAIR Phase 0 at GSI Helmholtzzentrum für Schwerionenforschung, Darmstadt. The goal was to improve the accuracy of the experimental data for the 12C(α,γ)16O fusion reaction and to reach lower center-ofmass energies than measured so far.
The experiment required beam intensities of 109 16O ions per second at an energy of 500 MeV/nucleon. The rare case of Coulomb breakup into 12C and 4He posed another challenge: The magnetic rigidities of the particles are so close because of the same mass-to-charge-number ratio A/Z = 2 for 16O, 12C and 4He. Hence, radical changes of the R3B setup were necessary. All detectors had slits to allow the passage of the unreacted 16O ions, while 4He and 12C would hit the detectors' active areas depending on the scattering angle and their relative energies. We developed and built detectors based on organic scintillators to track and identify the reaction products with sufficient precision.
SARS-CoV-2 contains a positive single-stranded RNA genome of approximately 30 000 nucleotides. Within this genome, 15 RNA elements were identified as conserved between SARS-CoV and SARS-CoV-2. By nuclear magnetic resonance (NMR) spectroscopy, we previously determined that these elements fold independently, in line with data from in vivo and ex-vivo structural probing experiments. These elements contain non-base-paired regions that potentially harbor ligand-binding pockets. Here, we performed an NMR-based screening of a poised fragment library of 768 compounds for binding to these RNAs, employing three different 1H-based 1D NMR binding assays. The screening identified common as well as RNA-element specific hits. The results allow selection of the most promising of the 15 RNA elements as putative drug targets. Based on the identified hits, we derive key functional units and groups in ligands for effective targeting of the RNA of SARS-CoV-2.
The neutron activation method is well-suited to investigate neutron-capture cross sections relevant for the main s-process component. Neutrons can be produced via the 7Li(p,n) reaction with proton energies of 1912 keV at e.g. Van de Graaff accelerators, which results in a quasi-Maxwellian spectrum of neutrons corresponding to a temperature of kBT = 25 keV. However, the weak s-process takes place in massive stars at temperatures between 25 and 90 keV. Simulations using the PINO code [2] suggest that a Maxwellian spectrum for higher energies, e.g. kBT = 90 keV, can be approximated by a linear combination of different neutron spectra. To validate the PINO code at proton energies Ep ≠ 1912 keV, neutron time-of-flight measurements were carried out at the PTB Ion Accelerator Facility (PIAF) at the Physikalisch-Technische Bundesanstalt in Braunschweig, Germany.
We measured the neutron capture cross sections of 69Ga and 71Ga for a quasi-stellar spectrum at kBT = 25 keV and a spectrum with a peak energy at 90 keV by the activation technique at the Joint Research Centre (JRC) in Geel, Belgium. Protons were provided by an electrostatic Van de Graaff accelerator to produce neutrons via the reaction 7Li(p,n). The produced activity was measured via the γ emission of the product nuclei by high-purity germanium detectors. We present preliminary results.