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Aduszkiewicz, Antoni ; Andronov, Evgeny V. ; Antičić, Tome ; Babkin, Vadim A. ; Baszczyk, Mateusz ; Bhosale, S. ; Blondel, A. ; Bogomilov, Mariyan ; Brandin, Andrei V. ; Bravar, Alessandro ; Bryliński, Wojciech ; Brzychczyk, Janusz ; Buryakov, M. ; Busygina, O. ; Bzdak, A. ; Cherif, H. ; Ćirković, M. ; Csanád, Máté ; Cybowska, J. ; Czopowicz, T. ; Damyanova, A. ; Davis, N. ; Deliyergiyev, M. ; Deveaux, Michael ; Dmitriev, A. ; Dominik, W. ; Dorosz, Piotr ; Dumarchez, J. ; Engel, Ralph ; Feofilov, Grigori A. ; Fields, L. ; Fodor, Zoltán ; Garibov, A. ; Gaździcki, Marek ; Golosov, Oleg ; Golovatyuk, V. ; Golubeva, Marina ; Grebieszkow, Katarzyna ; Guber, Fedor ; Haesler, A. ; Igolkin, Sergey N. ; Ilieva, Stoyanka ; Ivashkin, Alexander ; Johnson, S. R. ; Kadija, Krešo ; Kargin, N. ; Kashirin, E. ; Kiełbowicz, Mirosław ; Kireyeu, Viktar A. ; Klochkov, Viktor ; Kolesnikov, Vadim I. ; Kolev, D. ; Korzenev, A. ; Kovalenko, V. N. ; Kowalski, S. ; Koziel, Michal ; Krasnoperov, A. ; Kucewicz, Wojciech ; Kuich, M. ; Kurepin, Alexander ; Larsen, Dag Toppe ; László, A. ; Lazareva, Tatiana V. ; Lewicki, M. ; Łojek, K. ; Lyubushkin, V. V. ; Maćkowiak-Pawłowska, Maja ; Majka, Zbigniew ; Maksiak, B. ; Malakhov, Aleksandr I. ; Marcinek, A. ; Marino, A. D. ; Marton, K. ; Mathes, H.-J. ; Matulewicz, Tomasz ; Matveev, V. ; Melkumov, Georgy L. ; Merzlaya, Anastasia O. ; Messerly, B. ; Mik, Łukasz ; Morozov, Sergey ; Mrówczyński, Stanislaw ; Nagai, Y. ; Naskręt, Michał ; Ozvenchuk, Vitalii ; Paolone, V. ; Petukhov, Oleg ; Płaneta, Roman ; Podlaski, P. ; Popov, B. A. ; Porfy, B. ; Posiadała-Zezula, M. ; Prokhorova, D. S. ; Pszczel, Damian ; Puławski, S. ; Puzović, Jovan ; Ravonel, M. ; Renfordt, Rainer Arno Ernst ; Röhrich, Dieter ; Rondio, E. ; Roth, M. ; Rumberger, Brant T. ; Rumyantsev, M. ; Rustamov, Anar ; Rybczyński, Maciej ; Rybicki, Andrzej ; Sadovsky, Alexander ; Schmidt, K. ; Selyuzhenkov, Ilya ; Seryakov, A. Yu. ; Seyboth, Peter ; Słodkowski, M. ; Staszel, P. ; Stefanek, Grzegorz ; Stepaniak, J. ; Strichanov, Michail Nikolaevič ; Ströbele, Herbert ; Šuša, Tatjana ; Taranenko, Arkadiy ; Tefelska, A. ; Tefelski, Dariusz ; Tereshchenko, V. ; Toia, Alberica ; Tsenov, R. ; Turko, L. ; Ulrich, R. ; Unger, M. ; Uzhva, Denis ; Valiev, F. F. ; Veberič, Darko ; Vechernin, V. V. ; Wickremasinghe, A. ; Włodarczyk, Zbigniew ; Wojcik, K. ; Wyszyński, Oskar ; Zimmerman, E. D. ; Zwaska, Robert
his Erratum replaces incorrect plots shown in Fig. 7 with the corrected ones. In the publication, the NA57 [1] ratios of Ξ− and Ξ¯¯¯¯+ to the number of wounded nucleons at ⟨NW⟩=349 by mistake were plotted at the wrong values. The ratios were calculated and plotted by mistake using ⟨NW⟩=249.
The correct normalization does not change the conclusions of the paper. The correctly normalized results are presented in Fig. 7.
Aduszkiewicz, Antoni ; Andronov, Evgeny V. ; Antičić, Tome ; Babkin, Vadim A. ; Baszczyk, Mateusz ; Bhosale, S. ; Blondel, A. ; Bogomilov, Mariyan ; Brandin, Andrei V. ; Bravar, Alessandro ; Bryliński, Wojciech ; Brzychczyk, Janusz ; Buryakov, M. ; Busygina, O. ; Bzdak, A. ; Cherif, H. ; Ćirković, M. ; Csanád, Máté ; Cybowska, J. ; Czopowicz, T. ; Damyanova, A. ; Davis, N. ; Deliyergiyev, M. ; Deveaux, Michael ; Dmitriev, A. ; Dominik, W. ; Dorosz, Piotr ; Dumarchez, J. ; Engel, Ralph ; Feofilov, Grigori A. ; Fields, L. ; Fodor, Zoltán ; Garibov, A. ; Gaździcki, Marek ; Golosov, Oleg ; Golovatyuk, V. ; Golubeva, Marina ; Grebieszkow, Katarzyna ; Guber, Fedor ; Haesler, A. ; Igolkin, Sergey N. ; Ilieva, Stoyanka ; Ivashkin, Alexander ; Johnson, S. R. ; Kadija, Krešo ; Kargin, N. ; Kashirin, E. ; Kiełbowicz, Mirosław ; Kireyeu, Viktar A. ; Klochkov, Viktor ; Kolesnikov, Vadim I. ; Kolev, D. ; Korzenev, A. ; Kovalenko, V. N. ; Kowalski, S. ; Koziel, Michal ; Krasnoperov, A. ; Kucewicz, Wojciech ; Kuich, M. ; Kurepin, Alexander ; Larsen, Dag Toppe ; László, A. ; Lazareva, Tatiana V. ; Lewicki, M. ; Łojek, K. ; Lyubushkin, V. V. ; Maćkowiak-Pawłowska, Maja ; Majka, Zbigniew ; Maksiak, Bartosz ; Malakhov, Aleksandr I. ; Marcinek, A. ; Marino, A. D. ; Marton, K. ; Mathes, H.-J. ; Matulewicz, Tomasz ; Matveev, V. ; Melkumov, Georgy L. ; Merzlaya, Anastasia O. ; Messerly, B. ; Mik, Łukasz ; Morozov, Sergey ; Mrówczyński, Stanislaw ; Nagai, Y. ; Naskręt, Michał ; Ozvenchuk, Vitalii ; Paolone, V. ; Petukhov, Oleg ; Płaneta, Roman ; Podlaski, P. ; Popov, B. A. ; Porfy, B. ; Posiadała-Zezula, M. ; Prokhorova, D. S. ; Pszczel, Damian ; Puławski, Szymon ; Puzović, Jovan ; Ravonel, M. ; Renfordt, Rainer Arno Ernst ; Röhrich, Dieter ; Rondio, E. ; Roth, M. ; Rumberger, Brant T. ; Rumyantsev, M. ; Rustamov, Anar ; Rybczyński, Maciej ; Rybicki, Andrzej ; Sadovsky, Alexander ; Schmidt, K. ; Selyuzhenkov, Ilya ; Seryakov, A. Yu. ; Seyboth, Peter ; Słodkowski, M. ; Staszel, P. ; Stefanek, Grzegorz ; Stepaniak, J. ; Strichanov, Michail Nikolaevič ; Ströbele, Herbert ; Šuša, Tatjana ; Taranenko, Arkadiy ; Tefelska, A. ; Tefelski, Dariusz ; Tereshchenko, V. ; Toia, Alberica ; Tsenov, R. ; Turko, L. ; Ulrich, R. ; Unger, M. ; Uzhva, Denis ; Valiev, F. F. ; Veberič, Darko ; Vechernin, V. V. ; Wickremasinghe, A. ; Włodarczyk, Zbigniew ; Wojcik, K. ; Wyszyński, Oskar ; Zimmerman, E. D. ; Zwaska, Robert
The production of Ξ(1321)− and Ξ¯¯¯¯(1321)+ hyperons in inelastic p+p interactions is studied in a fixed target experiment at a beam momentum of 158 GeV/c. Double differential distributions in rapidity y and transverse momentum pT are obtained from a sample of 33M inelastic events. They allow to extrapolate the spectra to full phase space and to determine the mean multiplicity of both Ξ− and Ξ¯¯¯¯+. The rapidity and transverse momentum spectra are compared to transport model predictions. The Ξ− mean multiplicity in inelastic p+p interactions at 158 GeV/c is used to quantify the strangeness enhancement in A+A collisions at the same centre-of-mass energy per nucleon pair.
Acharya, A. ; Adhikary, H. ; Allison, K. K. ; Andronov, Evgeny V. ; Antičić, Tome ; Babkin, Vadim A. ; Baszczyk, Mateusz ; Bhosale, S. ; Blondel, A. ; Bogomilov, Mariyan ; Brandin, Andrei V. ; Bravar, Alessandro ; Bryliński, Wojciech ; Brzychczyk, Janusz ; Buryakov, M. ; Busygina, O. ; Bzdak, A. ; Cherif, H. ; Ćirković, M. ; Csanád, Máté ; Cybowska, J. ; Czopowicz, T. ; Damyanova, A. ; Davis, N. ; Deliyergiyev, M. ; Deveaux, Michael ; Dmitriev, A. ; Dominik, W. ; Dorosz, Piotr ; Dumarchez, J. ; Engel, Ralph ; Feofilov, Grigori A. ; Fields, L. ; Fodor, Zoltán ; Garibov, A. ; Gaździcki, Marek ; Golosov, Oleg ; Golovatyuk, V. ; Golubeva, Marina ; Grebieszkow, Katarzyna ; Guber, Fedor ; Haesler, A. ; Igolkin, Sergey N. ; Ilieva, Stoyanka ; Ivashkin, Alexander ; Johnson, S. R. ; Kadija, Krešo ; Kargin, N. ; Kashirin, E. ; Kiełbowicz, Mirosław ; Kireyeu, Viktar A. ; Klochkov, Viktor ; Kolesnikov, Vadim I. ; Kolev, D. ; Korzenev, A. ; Kovalenko, V. N. ; Kowalski, S. ; Koziel, Michal ; Kozłowski, B. ; Krasnoperov, A. ; Kucewicz, Wojciech ; Kuich, M. ; Kurepin, Alexander ; Larsen, Dag Toppe ; László, A. ; Lazareva, Tatiana V. ; Lewicki, M. ; Łojek, K. ; Lyubushkin, V. V. ; Maćkowiak-Pawłowska, Maja ; Majka, Zbigniew ; Maksiak, B. ; Malakhov, Aleksandr I. ; Marcinek, A. ; Marino, A. D. ; Marton, K. ; Mathes, H. -J. ; Matulewicz, Tomasz ; Matveev, V. ; Melkumov, Georgy L. ; Merzlaya, Anastasia O. ; Messerly, B. ; Mik, Łukasz ; Morozov, Sergey ; Nagai, Y. ; Naskręt, Michał ; Ozvenchuk, Vitalii ; Paolone, V. ; Petukhov, Oleg ; Pidhurskyi, I. ; Płaneta, Roman ; Podlaski, P. ; Popov, B. A. ; Porfy, B. ; Posiadała-Zezula, M. ; Prokhorova, D. S. ; Pszczel, Damian ; Puławski, S. ; Puzović, Jovan ; Ravonel, M. ; Renfordt, Rainer Arno Ernst ; Röhrich, Dieter ; Rondio, E. ; Roth, M. ; Rumberger, Brant T. ; Rumyantsev, M. ; Rustamov, Anar ; Rybczyński, Maciej ; Rybicki, Andrzej ; Sadhu, Samrangy ; Sadovsky, Alexander ; Schmidt, K. ; Selyuzhenkov, Ilya ; Seryakov, A. Yu. ; Seyboth, Peter ; Słodkowski, M. ; Staszel, P. ; Stefanek, Grzegorz ; Stepaniak, J. ; Strichanov, Michail Nikolaevič ; Ströbele, Herbert ; Šuša, Tatjana ; Taranenko, Arkadiy ; Tefelska, A. ; Tefelski, Dariusz ; Tereshchenko, V. ; Toia, Alberica ; Tsenov, R. ; Turko, L. ; Ulrich, R. ; Unger, M. ; Uzhva, Denis ; Valiev, F. F. ; Veberič, Darko ; Vechernin, V. V. ; Wickremasinghe, A. ; Wójcik, K. ; Wyszyński, Oskar ; Zaitsev, A. ; Zimmerman, E. D. ; Zwaska, Robert
The physics goal of the strong interaction program of the NA61/SHINE experiment at the CERN Super Proton Synchrotron (SPS) is to study the phase diagram of hadronic matter by a scan of particle production in collisions of nuclei with various sizes at a set of energies covering the SPS energy range. This paper presents differential inclusive spectra of transverse momentum, transverse mass and rapidity of π− mesons produced in central 40Ar+45Sc collisions at beam momenta of 13A, 19A, 30A, 40A, 75A and 150A Ge V /c. Energy and system size dependence of parameters of these distributions – mean transverse mass, the inverse slope parameter of transverse mass spectra, width of the rapidity distribution and mean multiplicity – are presented and discussed. Furthermore, the dependence of the ratio of the mean number of produced pions to the mean number of wounded nucleons on the collision energy was derived. The results are compared to predictions of several models.
Aduszkiewicz, Antoni ; Andronov, Evgeny V. ; Antičić, Tome ; Babkin, Vadim A. ; Baszczyk, Mateusz ; Bhosale, S. ; Blondel, A. ; Bogomilov, Mariyan ; Brandin, Andrei V. ; Bravar, Alessandro ; Bryliński, Wojciech ; Brzychczyk, Janusz ; Buryakov, M. ; Busygina, O. ; Bzdak, A. ; Cherif, H. ; Ćirković, M. ; Csanád, Máté ; Cybowska, J. ; Czopowicz, T. ; Damyanova, A. ; Davis, N. ; Deliyergiyev, M. ; Deveaux, Michael ; Dmitriev, A. ; Dominik, W. ; Dorosz, Piotr ; Dumarchez, J. ; Engel, Ralph ; Feofilov, Grigori A. ; Fields, L. ; Fodor, Zoltán ; Garibov, A. ; Gaździcki, Marek ; Golosov, Oleg ; Golovatyuk, V. ; Golubeva, Marina ; Grebieszkow, Katarzyna ; Guber, Fedor ; Haesler, A. ; Igolkin, Sergey N. ; Ilieva, Stoyanka ; Ivashkin, Alexander ; Johnson, S. R. ; Kadija, Krešo ; Kargin, N. ; Kashirin, E. ; Kiełbowicz, Mirosław ; Kireyeu, Viktar A. ; Klochkov, Viktor ; Kolesnikov, Vadim I. ; Kolev, D. ; Korzenev, A. ; Kovalenko, V. N. ; Kowalski, S. ; Koziel, Michal ; Krasnoperov, A. ; Kucewicz, Wojciech ; Kuich, M. ; Kurepin, Alexander ; Larsen, Dag Toppe ; László, A. ; Lazareva, Tatiana V. ; Lewicki, M. ; Łojek, K. ; Lyubushkin, V. V. ; Maćkowiak-Pawłowska, Maja ; Majka, Zbigniew ; Maksiak, Bartosz ; Malakhov, Aleksandr I. ; Marcinek, A. ; Marino, A. D. ; Marton, K. ; Mathes, H.-J. ; Matulewicz, Tomasz ; Matveev, V. ; Melkumov, Georgy L. ; Merzlaya, Anastasia O. ; Messerly, B. ; Mik, Łukasz ; Morozov, Sergey ; Mrówczyński, Stanislaw ; Nagai, Y. ; Naskręt, Michał ; Ozvenchuk, Vitalii ; Paolone, V. ; Petukhov, Oleg ; Płaneta, Roman ; Podlaski, P. ; Popov, B. A. ; Porfy, B. ; Posiadała-Zezula, M. ; Prokhorova, D. S. ; Pszczel, Damian ; Puławski, Szymon ; Puzović, Jovan ; Ravonel, M. ; Renfordt, Rainer Arno Ernst ; Röhrich, Dieter ; Rondio, E. ; Roth, M. ; Rumberger, Brant T. ; Rumyantsev, M. ; Rustamov, Anar ; Rybczyński, Maciej ; Rybicki, Andrzej ; Sadovsky, Alexander ; Schmidt, K. ; Selyuzhenkov, Ilya ; Seryakov, A. Yu. ; Seyboth, Peter ; Słodkowski, M. ; Staszel, P. ; Stefanek, Grzegorz ; Stepaniak, J. ; Strichanov, Michail Nikolaevič ; Ströbele, Herbert ; Šuša, Tatjana ; Taranenko, Arkadiy ; Tefelska, A. ; Tefelski, Dariusz ; Tereshchenko, V. ; Toia, Alberica ; Tsenov, R. ; Turko, L. ; Ulrich, R. ; Unger, M. ; Uzhva, Denis ; Valiev, F. F. ; Veberič, Darko ; Vechernin, V. V. ; Wickremasinghe, A. ; Włodarczyk, Zbigniew ; Wojcik, K. ; Wyszyński, Oskar ; Zimmerman, E. D. ; Zwaska, Robert
A measurement of charged hadron pair correlations in two-dimensional ηφ space is presented. The analysis is based on total 30 million central Be + Be collisions observed in the NA61/SHINE detector at the CERN SPS for incident beam momenta of 19A, 30A, 40A, 75A, and 150A GeV/c. Measurements were carried out for unlike-sign and like-sign charge hadron pairs independently. The C(η, φ) correlation functions were compared with results from a similar analysis on p + p interactions at similar beam momenta per nucleon. General trends of the backto-back correlations are similar in central Be + Be collisions and p + p interactions, but are suppressed in magnitude due to the increased combinatorial background. Predictions from the Epos and UrQMD models are compared to the measurements. Evolution of an enhancement around (η, φ) = (0, 0) with incident energy is observed in central Be + Be collisions. It is not predicted by both models and almost non-existing in proton–proton collisions at the same momentum per nucleon.
Belkum, Alex van ; Almeida, Carina ; Bardiaux, Benjamin ; Barrass, Sarah V. ; Butcher, Sarah J. ; Çaykara, Tuğçe ; Chowdhury, Sounak ; Datar, Rucha ; Eastwood, Ian ; Goldman, Adrian ; Goyal, Manisha ; Happonen, Lotta ; Izadi-Pruneyre, Nadia ; Jacobsen, Theis ; Johnson, Pirjo H. ; Kempf, Volkhard A. J. ; Kießling, Andreas ; Bueno, Juan Leva ; Malik, Anchal ; Malmström, Johan ; Meuskens, Ina ; Milner, Paul A. ; Nilges, Michael ; Pamme, Nicole ; Peyman, Sally A. ; Rodrigues, Ligia R. ; Rodriguez-Mateos, Pablo ; Sande, Maria G. ; Silva, Carla Joana ; Stasiak, Aleksandra Cecylia ; Stehle, Thilo ; Thibau, Arno ; Vaca Llerena, Diana Jaqueline ; Linke, Dirk
Infectious diseases are an existential health threat, potentiated by emerging and re-emerging viruses and increasing bacterial antibiotic resistance. Targeted treatment of infectious diseases requires precision diagnostics, especially in cases where broad-range therapeutics such as antibiotics fail. There is thus an increasing need for new approaches to develop sensitive and specific in vitro diagnostic (IVD) tests. Basic science and translational research are needed to identify key microbial molecules as diagnostic targets, to identify relevant host counterparts, and to use this knowledge in developing or improving IVD. In this regard, an overlooked feature is the capacity of pathogens to adhere specifically to host cells and tissues. The molecular entities relevant for pathogen–surface interaction are the so-called adhesins. Adhesins vary from protein compounds to (poly-)saccharides or lipid structures that interact with eukaryotic host cell matrix molecules and receptors. Such interactions co-define the specificity and sensitivity of a diagnostic test. Currently, adhesin-receptor binding is typically used in the pre-analytical phase of IVD tests, focusing on pathogen enrichment. Further exploration of adhesin–ligand interaction, supported by present high-throughput “omics” technologies, might stimulate a new generation of broadly applicable pathogen detection and characterization tools. This review describes recent results of novel structure-defining technologies allowing for detailed molecular analysis of adhesins, their receptors and complexes. Since the host ligands evolve slowly, the corresponding adhesin interaction is under selective pressure to maintain a constant receptor binding domain. IVD should exploit such conserved binding sites and, in particular, use the human ligand to enrich the pathogen. We provide an inventory of methods based on adhesion factors and pathogen attachment mechanisms, which can also be of relevance to currently emerging pathogens, including SARS-CoV-2, the causative agent of COVID-19.
Lawes, Michael J. ; Fisher, Diana O. ; Johnson, Chris N. ; Blomberg, Simon P. ; Frank, Anke S. K. ; Fritz, Susanne A. ; McCallum, Hamish ; Van Der Wal, Jeremy ; Abbott, Brett N. ; Legge, Sarah ; Letnic, Mike ; Thomas, Colette R. ; Thurgate, Nikki ; Fisher, Alaric ; Gordon, Iain J. ; Kutt, Alex
Australia has experienced dramatic declines and extinctions of its native rodent species over the last 200 years, particularly in southern Australia. In the tropical savanna of northern Australia significant declines have occurred only in recent decades. The later onset of these declines suggests that the causes may differ from earlier declines in the south. We examine potential regional effects (northern versus southern Australia) on biological and ecological correlates of range decline in Australian rodents. We demonstrate that rodent declines have been greater in the south than in the tropical north, are strongly influenced by phylogeny, and are consistently greater for species inhabiting relatively open or sparsely vegetated habitat. Unlike in marsupials, where some species have much larger body size than rodents, body mass was not an important predictor of decline in rodents. All Australian rodent species are within the prey-size range of cats (throughout the continent) and red foxes (in the south). Contrary to the hypothesis that mammal declines are related directly to ecosystem productivity (annual rainfall), our results are consistent with the hypothesis that disturbances such as fire and grazing, which occur in non-rainforest habitats and remove cover used by rodents for shelter, nesting and foraging, increase predation risk. We agree with calls to introduce conservation management that limits the size and intensity of fires, increases fire patchiness and reduces grazing impacts at ecological scales appropriate for rodents. Controlling feral predators, even creating predator-free reserves in relatively sparsely-vegetated habitats, is urgently required to ensure the survival of rodent species, particularly in northern Australia where declines are not yet as severe as those in the south.
Wolking, Stefan ; Schulz, Herbert ; Nies, Anne T ; McCormack, Mark ; Schäffeler, Elke ; Auce, Pauls ; Avbersek, Andreja ; Becker, Felicitas ; Klein, Karl Martin ; Krenn, Martin ; Møller, Rikke S. ; Nikanorova, Marina ; Weckhuysen, Sarah ; Cavalleri, Gianpiero L. ; Delanty, Norman ; Depondt, Chantal ; Johnson, Michael R. ; Koeleman, Bobby P. C. ; Kunz, Wolfram S. ; Marson, Anthony G. ; Sander, Josemir W. ; Sills, Graeme J. ; Striano, Pasquale ; Zara, Federico J. ; Zimprich, Fritz ; Weber, Yvonne G. ; Krause, Roland ; Sisodiya, Sanjay M. ; Schwab, Matthias ; Sander, Thomas ; Lerche, Holger
Aim: Pharmacoresistance is a major burden in epilepsy treatment. We aimed to identify genetic biomarkers in response to specific antiepileptic drugs (AEDs) in genetic generalized epilepsies (GGE). Materials & methods: We conducted a genome-wide association study (GWAS) of 3.3 million autosomal SNPs in 893 European subjects with GGE – responsive or nonresponsive to lamotrigine, levetiracetam and valproic acid. Results: Our GWAS of AED response revealed suggestive evidence for association at 29 genomic loci (p <10-5) but no significant association reflecting its limited power. The suggestive associations highlight candidate genes that are implicated in epileptogenesis and neurodevelopment. Conclusion: This first GWAS of AED response in GGE provides a comprehensive reference of SNP associations for hypothesis-driven candidate gene analyses in upcoming pharmacogenetic studies.