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Asplenium adiantum-nigrum (Aspleniaceae, Pteridophyta) breitet sich seit ca. 20 Jahren von seinem Arealrand im Rheinisch-Westfälischen Mittelgebirge ins Tiefland hinein aus. Die bislang in Nordrhein-Westfalen collin-montan verbreitete Farnart besaß dort bis zum Ende der 1980er Jahre eine stabile Verbreitungsgrenze mit Vorkommen an Felsstandorten des Ruhrtals (südliches Ruhrgebiet). Ausbreitungsgeschichte, Populationsentwicklung, Gesellschaftsanschluss sowie die neuen Wuchsorte werden dargestellt. Insgesamt konnten seit 1990 25 Neufunde, 16 davon im planaren Raum des Niederrheinischen Tieflandes und der Westfälischen Bucht, mit einer Gesamtpopulation von über 580 Individuen verzeichnet werden. Die Ursachen der Arealerweiterung werden anhand von vier Hypothesen und unter Berücksichtigung von Untersuchungsergebnissen aus West- und Nordwesteuropa diskutiert. Eine derzeit häufig diskutierte mögliche Ursache der Arealerweiterung ist die seit Jahren erkennbare Klimaerwärmung, bei der insbesondere die milderen Winter und wärmeren Sommer u.a. zu einer Veränderung der Luftfeuchtigkeit führen. Diese scheidet jedoch im Falle von Asplenium adiatum-nigrum zumindest als monokausale Erklärung aus. Die veränderten klimatischen Faktoren überlagern sich zeitgleich mit einer einhergehenden Luftverbesserung (insbesondere Verringerung der SO2-Immissionen) und höheren Stickstoffimmissionen, welche letztlich die Wuchsbedingungen des Farntaxons insgesamt positiv beeinflussen können. Ein belegbarer Zusammenhang zwischen Ausbreitung des Taxons und den veränderten Klima- sowie Umweltbedingungen ist derzeit allerdings nicht gegeben.
Steidl, Eike ; Langen, Karl-Josef ; Abu Hmeidan, Sarah ; Polomac, Nenad ; Filß, Christian ; Galldiks, Norbert ; Lohmann, Philipp ; Keil, Fee ; Filipski, Katharina Johanna ; Mottaghy, Felix ; Shah, N. Jon ; Steinbach, Joachim Peter ; Hattingen, Elke ; Maurer, Gabriele D.
Purpose: Perfusion-weighted MRI (PWI) and O-(2-[18F]fluoroethyl-)-l-tyrosine ([18F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [18F]FET PET.
Methods: We evaluated 104 patients with WHO grade II–IV glioma and suspected TP on conventional MRI using PWI and dynamic [18F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBVmax) were obtained from dynamic susceptibility contrast PWI. Furthermore, we calculated static (i.e., maximum tumor to brain ratios; TBRmax) and dynamic [18F]FET PET parameters (i.e., Slope). Definitive diagnoses were based on histopathology (n = 42) or clinico-radiological follow-up (n = 62). The diagnostic performance of PWI and [18F]FET PET parameters to differentiate TP from TRC was evaluated by analyzing receiver operating characteristic and area under the curve (AUC).
Results: Across all patients, the differentiation of TP from TRC using rCBVmax or [18F]FET PET parameters was moderate (AUC = 0.69–0.75; p < 0.01). A rCBVmax cutoff > 2.85 had a positive predictive value for TP of 100%, enabling a correct TP diagnosis in 44 patients. In the remaining 60 patients, combined static and dynamic [18F]FET PET parameters (TBRmax, Slope) correctly discriminated TP and TRC in a significant 78% of patients, increasing the overall accuracy to 87%. A subgroup analysis of isocitrate dehydrogenase (IDH) mutant tumors indicated a superior performance of PWI to [18F]FET PET (AUC = 0.8/< 0.62, p < 0.01/≥ 0.3).
Conclusion: While marked hyperperfusion on PWI indicated TP, [18F]FET PET proved beneficial to discriminate TP from TRC when PWI remained inconclusive. Thus, our results highlight the clinical value of sequential use of PWI and [18F]FET PET, allowing an economical use of diagnostic methods. The impact of an IDH mutation needs further investigation.
Im Rahmen stadtfloristischer Untersuchungen des Ruhrgebietes wurden in Brunnen- und Kellerlichtschächten Vorkommen von Pteris cretica var. albolineata (Pteridaceae) und Adiantum raddianum (Adiantaceae) nachgewiesen, beide taxonomisch im weiteren Sinne zu verstehen. Die Wuchsorte, Populationsgrößen und Begleitvegetation werden beschrieben, Status und Ausbreitungstendenzen der Taxa diskutiert.
Dubinski, Daniel ; Won, Sae-Yeon ; Keil, Fee ; Behmanesh, Bedjan ; Dosch, Max ; Baumgarten, Peter ; Bernstock, Joshua D. ; Seifert, Volker ; Freiman, Thomas Michael ; Geßler, Florian
Purpose: In patients with pyogenic spondylodiscitis, surgery is considered the treatment of choice to conduct proper debridement, stabilise the spine and avoid extended bed rest, which in turn is a risk factor for complications such as deep vein thrombosis and pulmonary embolism. Methods: We conducted a retrospective clinical study with analysis of a group of 99 patients who had undergone treatment for pyogenic discitis at our institution between June 2012 and August 2017. Included parameters were age, sex, disease pattern, the presence of deep vein thrombosis, resuscitation, in-hospital mortality, present anticoagulation, preexisting comorbidities, tobacco abuse, body mass index, microbiological germ detection and laboratory results. Results: Among the analysed cohort, 12% of the treated patients for pyogenic spondylodiscitis suffered from a radiologically confirmed pulmonary embolism. Coronary heart disease (p < 0.01), female sex (p < 0.01), anticoagulation at admission (p < 0.01) and non-O blood type (p < 0.001) were associated with development of pulmonary embolism. Pulmonary embolism was significantly associated with resuscitation (p < 0.005) and deep vein thrombosis (p < 0.001). Neurosurgery was not associated with increased risk for pulmonary embolism compared to conservative-treated patients (p > 0.05). Conclusion: Surgery for pyogenic spondylodiscitis was not associated with an elevated risk of pulmonary embolism in our analysis. However, we describe several risk factors for pulmonary embolism in this vulnerable cohort. Prospective studies are necessary to improve prevention and postoperative management in patients with pyogenic spondylodiscitis.
Meningioma surgery in patients ≥70 years of age: clinical outcome and validation of the SKALE score
(2021)
Monden, Daniel ; Raimann, Florian ; Neef, Vanessa ; Dubinski, Daniel ; Geßler, Florian ; Keil, Fee ; Forster, Marie-Thérèse ; Ronellenfitsch, Michael Wilfried ; Harter, Patrick Nikolaus ; Freiman, Thomas Michael ; Hattingen, Elke ; Seifert, Volker ; Senft, Christian ; Baumgarten, Peter
Along with increasing average life expectancy, the number of elderly meningioma patients has grown proportionally. Our aim was to evaluate whether these specific patients benefit from surgery and to investigate a previously published score for decision-making in meningioma patients (SKALE). Of 421 patients who underwent primary intracranial meningioma resection between 2009 and 2015, 71 patients were ≥70 years of age. We compared clinical data including World Health Organization (WHO) grade, MIB-1 proliferation index, Karnofsky Performance Status Scale (KPS), progression free survival (PFS) and mortality rate between elderly and all other meningioma patients. Preoperative SKALE scores (Sex, KPS, ASA score, location and edema) were determined for elderly patients. SKALE ≥8 was set for dichotomization to determine any association with outcome parameters. In 71 elderly patients (male/female 37/34) all data were available. Postoperative KPS was significantly lower in elderly patients (p < 0.0001). Pulmonary complications including pneumonia (10% vs. 3.2%; p = 0.0202) and pulmonary embolism (12.7% vs. 6%; p = 0.0209) occurred more frequently in our elderly cohort. Analyses of the Kaplan Meier curves revealed differences in three-month (5.6% vs. 0.3%; p = 0.0033), six-month (7% vs. 0.3%; p = 0.0006) and one-year mortality (8.5% vs. 0.3%; p < 0.0001) for elderly patients. Statistical analysis showed significant survival benefit in terms of one-year mortality for elderly patients with SKALE scores ≥8 (5.1 vs. 25%; p = 0.0479). According to our data, elderly meningioma patients face higher postoperative morbidity and mortality than younger patients. However, resection is reasonable for selected patients, particularly when reaching a SKALE score ≥ 8.
Im Rahmen von Geländeuntersuchungen zur Vegetation der Feuchtwälder des Duisburg-Mülheimer Waldes (westliches Ruhrgebiet, Nordrhein-Westfalen) wurden im Frühjahr 2002 an zwei Stellen Vorkommen von Lysichiton americanus entdeckt. Ein älteres, bislang nicht publiziertes Vorkommen aus dem Jahr 1980 konnte bestätigt werden. Lysichiton americanus hat sich hier in naturnahen Quell- und Auwäldern angesiedelt. Eine Gefährdung von der als invasiv eingeschätzten Sippe gegenüber indigenen Taxa wird diskutiert.
Dubinski, Daniel ; Won, Sae-Yeon ; Voß, Martin ; Keil, Fee ; Miesbach, Wolfgang ; Behmanesh, Bedjan ; Dosch, Max ; Baumgarten, Peter ; Bernstock, Joshua D. ; Seifert, Volker ; Freiman, Thomas Michael ; Geßler, Florian
Glioblastoma (GBM) is a cancer type with high thrombogenic potential and GBM patients are therefore at a particularly high risk for thrombotic events. To date, only limited data on anticoagulation management after pulmonary embolism (PE) in GBM is available and the sporadic use of DOACs remains off-label. A retrospective cohort analysis of patients with GBM and postoperative, thoracic CT scan confirmed PE was performed. Clinical course, follow-up at 6 and 12 months and the overall survival (OS) were evaluated using medical charts and neuroradiological data. Out of 584 GBM patients, 8% suffered from postoperative PE. Out of these, 30% received direct oral anticoagulants (DOACs) and 70% low-molecular-weight heparin (LMWH) for therapeutic anticoagulation. There was no significant difference in major intracranial hemorrhage (ICH), re-thrombosis, or re-embolism between the two cohorts. Although statistically non-significant, a tendency to reduced mRS at 6 and 12 months was observed in the LMWH cohort. Furthermore, patients receiving DOACs had a statistical benefit in OS. In our analysis, DOACs showed a satisfactory safety profile in terms of major ICH, re-thrombosis, and re-embolism compared to LMWH in GBM patients with postoperative PE. Prospective, randomized trials are urgent to evaluate DOACs for therapeutic anticoagulation in GBM patients with PE.
Dubinski, Daniel ; Won, Sae-Yeon ; Voß, Martin ; Keil, Fee ; Miesbach, Wolfgang ; Behmanesh, Bedjan ; Dosch, Max ; Baumgarten, Peter ; Bernstock, Joshua D. ; Seifert, Volker ; Freiman, Thomas Michael ; Geßler, Florian
Background: Glioblastoma (GBM) is a cancer type with high thrombogenic potential and GBM patients are therefore at a particularly high risk for thrombotic events. To date only limited data on anticoagulation management after pulmonary embolism (PE) in GBM is available and the sporadic use of DOACs remains off-label.
Methods: A retrospective cohort analysis of patients with GBM and postoperative, thoracic CT-scan confirmed, PE was performed. Clinical course, follow-up at 6 and 12 months and the overall survival (OS) were evaluated using medical charts and neuroradiological data.
Results: Out of 584 GBM patients, 8% suffered from postoperative PE. Out of theses, 30% received direct oral anticoagulants (DOACs) and 70% low-molecular-weight heparin (LMWH) for therapeutic anticoagulation. There was no significant difference in major intracranial hemorrhage (ICH), re-thrombosis or re-embolism between the two cohorts. Although statistically non-significant, a tendency to reduced mRS at 6- and 12 months was observed in the LMWH cohort. Furthermore, patients receiving DOACs had a statistical benefit in OS.
Conclusion: In our analysis DOACs showed a satisfactory safety profile in terms of major ICH, re-thrombosis and re-embolism compared to LMWH in GBM patients with postoperative PE. Prospective, randomized trials are urgent to evaluate DOACs for therapeutic anticoagulation in GBM patients with PE.