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Cannabis is the most commonly used illicit drug in the world. However, because of a changing legal landscape and rising interest in therapeutic utility, there is an increasing trend in (long-term) use and possibly cannabis impairment. Importantly, a growing body of evidence suggests that regular cannabis users develop tolerance to the impairing, as well as the rewarding, effects of the drug. However, the neuroadaptations that may underlie cannabis tolerance remain unclear. Therefore, this double-blind, randomized, placebo-controlled, cross-over study assessed the acute influence of cannabis on the brain and behavioral outcomes in two distinct cannabis user groups. Twelve occasional and 12 chronic cannabis users received acute doses of cannabis (300-μg/kg delta-9-tetrahydrocannabinol) and placebo and underwent ultrahigh field functional magnetic resonance imaging and magnetic resonance spectroscopy. In occasional users, cannabis induced significant neurometabolic alterations in reward circuitry, namely, decrements in functional connectivity and increments in striatal glutamate concentrations, which were associated with increases in subjective high and decreases in performance on a sustained attention task. Such changes were absent in chronic users. The finding that cannabis altered circuitry and distorted behavior in occasional, but not chronic users, suggests reduced responsiveness of the reward circuitry to cannabis intoxication in chronic users. Taken together, the results suggest a pharmacodynamic mechanism for the development of tolerance to cannabis impairment, of which is important to understand in the context of the long-term therapeutic use of cannabis-based medications, as well as in the context of public health and safety of cannabis use when performing day-to-day operations.
Curius punctatus (Fisher) : new combination (Coleoptera: Cerambycidae: Cerambycinae: Curiini)
(2005)
Hintergrund: Ab Frühjahr 2020 kam es zur weltweiten Verbreitung von SARS-CoV‑2 mit der heute als erste Welle der Pandemie bezeichneten Phase ab März 2020. Diese resultierte an vielen Kliniken in Umstrukturierungen und Ressourcenverschiebungen. Ziel unserer Arbeit war die Erfassung der Auswirkungen der Pandemie auf die universitäre Hals-Nasen-Ohren(HNO)-Heilkunde für die Forschung, Lehre und Weiterbildung. Material und Methoden: Die Direktorinnen und Direktoren der 39 Universitäts-HNO-Kliniken in Deutschland wurden mithilfe einer strukturierten Online-Befragung zu den Auswirkungen der Pandemie im Zeitraum von März bis April 2020 auf die Forschung, Lehre und die Weiterbildung befragt. Ergebnisse: Alle 39 Direktorinnen und Direktoren beteiligten sich an der Umfrage. Hiervon gaben 74,4 % (29/39) an, dass es zu einer Verschlechterung ihrer Forschungstätigkeit infolge der Pandemie gekommen sei. Von 61,5 % (24/39) wurde berichtet, dass pandemiebezogene Forschungsaspekte aufgegriffen wurden. Von allen Kliniken wurde eine Einschränkung der Präsenzlehre berichtet und 97,5 % (38/39) führten neue digitale Lehrformate ein. Im Beobachtungszeitraum sahen 74,4 % der Klinikdirektoren die Weiterbildung der Assistenten nicht gefährdet. Schlussfolgerung: Die Ergebnisse geben einen Einblick in die heterogenen Auswirkungen der Pandemie. Die kurzfristige Bearbeitung pandemiebezogener Forschungsthemen und die Einführung innovativer digitaler Konzepte für die studentische Lehre belegt eindrücklich das große innovative Potenzial und die schnelle Reaktionsfähigkeit der HNO-Universitätskliniken, um auch während der Pandemie ihre Aufgaben in der Forschung, Lehre und Weiterbildung bestmöglich zu erfüllen.
The recruitment processes and resulting distribution pattern of bird-dispersed Canary Island Date Palm, Phoenix canariensis (family Arecaceae) in a riverine forest setting are described. All palms on a near-urban peninsula of the Murrumbidgee River near Hay, New South Wales were GPS mapped and classified into height-dependent age categories. The distribution of the plants was examined spatially in relation to possible source palms and in relation to elevation with regard to flooding levels. Successful recruitment is subject to a range of environmental parameters, primarily palatability to vectors and seedling mortality due to lack of moisture, frost or grazing by herbivores. If a seedling survives that critical period of the first 18 months, long-term success is (almost) guaranteed, unless catastrophic events (bushfires, prolonged flooding) intervene. Based on the findings, a conceptual model for the recruitment of Phoenix canariensis palms is provided. Even though the palms produce fruit for much of the year (March–December), the time window for successful recruitment is restricted to a period from August to mid-September with short shoulder periods on either side.
The Southeast Asian Pholcus halabala species group is revised and re-delimited, based mainly on field observations (life color pattern, web design, position of egg-sac when carried by female, microhabitat) and ultrastructure (silk spigots, modifications of male cheliceral apophyses). The core group includes six leafdwelling species that have distinctive color patterns in life specimens (black and white or yellowish abdominal marks, dark pattern on posterior half of carapace) and build round to oval silk platforms on the undersides of leaves. Seven further species are tentatively assigned to the group pending further study. Several species originally assigned to the Pholcus halabala group are transferred to three newly proposed species groups, the Ph. krabi, Ph. buatong, and Ph. andulau groups. Nine species are newly described, four in the Ph. halabala group (Ph. khaolek Huber, sp. nov.; Ph. kuhapimuk Huber, sp. nov.; Ph. lintang Huber, sp. nov.; Ph. ubin Huber, sp. nov.); three in the Ph. krabi group (Ph. kipungit Huber, sp. nov.; Ph. krabi Huber, sp. nov.; Ph. narathiwat Huber, sp. nov.); one in the Ph. buatong group (Ph. buatong Huber, sp. nov.); and one in the Ph. andulau group (Ph. lambir Huber, sp. nov.). The females of Ph. satun Huber, 2011 and Ph. schwendingeri Huber, 2011 (both members of the buatong group) are newly described.