Refine
Has Fulltext
- yes (2)
Is part of the Bibliography
- no (2)
Keywords
- CBA (1)
- CRVO (1)
- IL-6 (1)
- Interpretation (1)
- Krolow, Karl (1)
- Liebeslyrik (1)
- MCP-1 (1)
- Naturlyrik (1)
- SD-OCT (1)
- VEGF (1)
Was im modernen Gedicht alles nicht mehr geht, meinte Gottfried Benn in seinem Marburger Vortrag über Lyrik diagnostizieren oder gar festlegen zu müssen: die Andichtung eines Du, die malerische Farbe (mit Ausnahme des Blau), der Wie-Vergleich und der seraphische, sentimental säuselnde Liebeston. Der Vortrag, kurz vor Entstehung des hier abgedruckten Krolow-Gedichts gehalten, hat wohl weniger prononcierten Einfluß auf ihn gehabt, doch lassen sich, wie im folgenden deutlich werden soll, gewisse Parallelen ausfindig machen: Themen des schwierig gewordenen Idylls, der unsicheren Liebesbeziehung, der Anonymisierung und Selbstdistanz des Autors sollen hervorgehoben werden, aber auch das Konzept des Gedichts als Spielraum, in dem das Individuum ins Allgemeine aufgehoben ist.
Purpose: To correlate inflammatory and proangiogenic key cytokines from undiluted vitreous of treatment-naïve central retinal vein occlusion (CRVO) patients with SD-OCT parameters.
Methods: Thirty-five patients (age 71.1 years, 24 phakic, 30 nonischemic) underwent intravitreal combination therapy, including a single-site 23-gauge core vitrectomy. Twenty-eight samples from patients with idiopathic, non-uveitis floaterectomy served as controls. Interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF-A) levels were correlated with the visual acuity (logMar), category of CRVO (ischemic or nonischemic) and morphologic parameters, such as central macular thickness-CMT, thickness of neurosensory retina-TNeuro, extent of serous retinal detachment-SRT and disintegrity of the IS/OS and others.
Results: The mean IL-6 was 64.7pg/ml (SD ± 115.8), MCP-1 1015.7 ( ± 970.1), and VEGF-A 278.4 ( ± 512.8), which was significantly higher than the control IL-6 6.2 ± 3.4pg/ml (P=0.06), MCP-1 253.2 ± 73.5 (P<0.0000001) and VEGF-A 7.0 ± 4.9 (P<0.0006). All cytokines correlated highly with one another (correlation coefficient r=0.82 for IL-6 and MCP-1; r=0.68 for Il-6 and VEGF-A; r=0.64 for MCP-1 and VEGF-A). IL-6 correlated significantly with CMT, TRT, SRT, dIS/OS, and dELM. MCP-1 correlated significantly with SRT, dIS/OS, and dELM. VEGF-A correlated not with changes in SD-OCT, while it had a trend to be higher in the ischemic versus the nonischemic CRVO group (P=0.09).
Conclusions: The inflammatory cytokines were more often correlated with morphologic changes assessed by SD-OCT, whereas VEGF-A did not correlate with CRVO-associated changes in SD-OCT. VEGF inhibition alone may not be sufficient in decreasing the inflammatory response in CRVO therapy.