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This paper presents the results of Open Quotient measurements in EGG signals of young (18 to 30 year old) and elderly (59 to 82 year old) male and female speakers. The paper further presents quantitative results on the relation between the OQ and the perception of a speaker's age. Higgins & Saxman (1991) found a decreased OQEGG with increasing age for females, whereas the OQEGG in sustained vowel material increased for males as the speakers age increased. In Linville (2002), however, the spectral amplitudes in the region of F0 (obtained by LTAS-measurements of read speech material) increased with increasing age independent of gender; this could be interpreted indirectly as an increasing OQ. We measured the OQEGG not only for sustained vowels, but also in vowels taken from isolated words. In order to analyse the relation between breathiness in terms of an increased OQ and the mean perceived age per stimulus a perception test was carried out in which listeners were asked to estimate speaker's age based on sustained /a/-vowel stimuli varying in vocal effort (soft - normal - loud) during production. The results indicated the following: (i) The decreased OQ for elderly females originally found by Higgins & Saxman is not apparent in our data for sustained /a/-vowels. For our female speakers no significant difference between the OQ of young and old speakers was found; for elderly males, however, we also found an increasing OQ with increasing age.(ii) In addition, a statistically significant increased OQEGG occurs for the group of the elderly males for the vowels from the word material. (iii) Our results show a strong positive relation between perceived age and OQ in male voices. Regarding (i) and (ii), at least the male speaker's voice becomes more breathy as age increases. Considering (iii), increased breathiness may contribute to the listener’s perception of increased age.
TRIANNI mice carry an entire set of human immunoglobulin V region gene segments and are a powerful tool to rapidly isolate human monoclonal antibodies. After immunizing these mice with DNA encoding the spike protein of SARS-CoV-2 and boosting with spike protein, we identified 29 hybridoma antibodies that reacted with the SARS-CoV-2 spike protein. Nine antibodies neutralize SARS-CoV-2 infection at IC50 values in the subnanomolar range. ELISA-binding studies and DNA sequence analyses revealed one cluster of three clonally related neutralizing antibodies that target the receptor-binding domain and compete with the cellular receptor hACE2. A second cluster of six clonally related neutralizing antibodies bind to the N-terminal domain of the spike protein without competing with the binding of hACE2 or cluster 1 antibodies. SARS-CoV-2 mutants selected for resistance to an antibody from one cluster are still neutralized by an antibody from the other cluster. Antibodies from both clusters markedly reduced viral spread in mice transgenic for human ACE2 and protected the animals from SARS-CoV-2-induced weight loss. The two clusters of potent noncompeting SARS-CoV-2 neutralizing antibodies provide potential candidates for therapy and prophylaxis of COVID-19. The study further supports transgenic animals with a human immunoglobulin gene repertoire as a powerful platform in pandemic preparedness initiatives.
The Coulomb Dissociation (CD) cross sections of the stable isotopes 92,94,100Mo and of the unstable isotope 93Mo were measured at the LAND/R3B setup at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Experimental data on these isotopes may help to explain the problem of the underproduction of 92,94Mo and 96,98Ru in the models of p-process nucleosynthesis. The CD cross sections obtained for the stable Mo isotopes are in good agreement with experiments performed with real photons, thus validating the method of Coulomb Dissociation. The result for the reaction 93Mo(γ,n) is especially important since the corresponding cross section has not been measured before. A preliminary integral Coulomb Dissociation cross section of the 94Mo(γ,n) reaction is presented. Further analysis will complete the experimental database for the (γ,n) production chain of the p-isotopes of molybdenum.
The growth of freshly formed aerosol particles can be the bottleneck in their survival to cloud condensation nuclei. It is therefore crucial to understand how particles grow in the atmosphere. Insufficient experimental data has impeded a profound understanding of nano-particle growth under atmospheric conditions. Here we study nano-particle growth in the CLOUD (Cosmics Leaving OUtdoors Droplets) chamber, starting from the formation of molecular clusters. We present measured growth rates at sub-3 nm sizes with different atmospherically relevant concentrations of sulphuric acid, water, ammonia and dimethylamine. We find that atmospheric ions and small acid-base clusters, which are not generally accounted for in the measurement of sulphuric acid vapour, can participate in the growth process, leading to enhanced growth rates. The availability of compounds capable of stabilizing sulphuric acid clusters governs the magnitude of these effects and thus the exact growth mechanism. We bring these observations into a coherent framework and discuss their significance in the atmosphere.