Refine
Author
- Nöthen, Markus Maria (5)
- Reif, Andreas (5)
- Bauer, Michael (4)
- Forstner, Andreas Josef (4)
- Fullerton, Janice M. (4)
- Mitchell, Philip B. (4)
- Pfennig, Andrea (4)
- Rietschel, Marcella (4)
- Alda, Martin (3)
- Baune, Bernhard T. (3)
- Cichon, Sven (3)
- Cruceanu, Cristiana (3)
- Czerski, Piotr M. (3)
- Degenhardt, Franziska (3)
- Grigoroiu-Serbanescu, Maria (3)
- Hauser, Joanna (3)
- Herms, Stefan (3)
- Hoffmann, Per (3)
- Kircher, Tilo (3)
- Landén, Mikael (3)
- Maier, Wolfgang (3)
- Rouleau, Guy A. (3)
- Schofield, Peter R. (3)
- Schulze, Thomas Gerd (3)
- Stamm, Thomas (3)
- Turecki, Gustavo (3)
- Wright, Adam (3)
- Adli, Mazda (2)
- Akula, Nirmala (2)
- Ardau, Raffaella (2)
- Arias, Bárbara (2)
- Aubry, Jean-Michel (2)
- Backlund, Lena (2)
- Bauer, Jochen (2)
- Bauer, Sebastian (2)
- Bellivier, Frank (2)
- Bengesser, Susanne (2)
- Bhattacharjee, Abesh Kumar (2)
- Biernacka, Joanna (2)
- Birner, Armin (2)
- Brichant-Petitjean, Clara (2)
- Cervantes, Pablo (2)
- Chillotti, Caterina (2)
- Colom, Francesc (2)
- Dannlowski, Udo (2)
- Dayer, Alexandre (2)
- DePaulo, J. Raymond (2)
- Del Zompo, Maria (2)
- Falkai, Peter (2)
- Frye, Mark A. (2)
- Gard, Sébastien (2)
- Garnham, Julie S. (2)
- Goes, Fernando S. (2)
- Grotegerd, Dominik (2)
- Gruber, Oliver (2)
- Hahn, Tim (2)
- Heilbronner, Urs (2)
- Hofmann, Andrea (2)
- Hou, Liping (2)
- Jamain, Stephane (2)
- Jansen, Andreas (2)
- Jiménez, Esther (2)
- Kahn, Jean-Pierre (2)
- Kassem, Layla (2)
- Kelsoe, John R. (2)
- Kittel-Schneider, Sarah (2)
- König, Barbara (2)
- Laje, Gonzalo (2)
- Lavebratt, Catharina (2)
- Leboyer, Marion (2)
- Leckband, Susan G. (2)
- Maaser, Anna (2)
- Maj, Mario (2)
- Manchia, Mirko (2)
- Martin, Nicholas Gordon (2)
- Martinsson, Lina (2)
- McCarthy, Michael J. (2)
- McMahon, Francis J. (2)
- Medland, Sarah E. (2)
- Mitjans, Marina (2)
- Moebus, Susanne (2)
- Mondimore, Francis Mark (2)
- Monteleone, Palmiero (2)
- Montgomery, Grant W. (2)
- Mühleisen, Thomas W. (2)
- Nievergelt, Caroline M. (2)
- Novák, Tomas (2)
- Potash, James B. (2)
- Reininghaus, Eva (2)
- Rybakowski, Janusz K. (2)
- Schalling, Martin (2)
- Schumacher, Johannes (2)
- Schweizer, Barbara W. (2)
- Severino, Giovanni (2)
- Shekhtman, Tatyana (2)
- Shilling, Paul D. (2)
- Simhandl, Christian (2)
- Slaney, Claire M. (2)
- Squassina, Alessio (2)
- Stopkova, Pavla (2)
- Streit, Fabian (2)
- Strohmaier, Jana (2)
- Tortorella, Alfonso (2)
- Vieta, Eduard (2)
- Völzke, Henry (2)
- Witt, Stephanie H. (2)
- Zandi, Peter P. (2)
- Étain, Bruno (2)
- Ösby, Urban (2)
- Abecasis, Gonçalo R. (1)
- Abramova, Lilia I. (1)
- Absher, Devin (1)
- Abé, Christoph (1)
- Agartz, Ingrid (1)
- Akiyama, Kazufumi (1)
- Akudjedu, Theophilus N. (1)
- Albrecht, Eva (1)
- Alexander, Nina (1)
- Allen, Nicholas B. (1)
- Amare, Azmeraw T. (1)
- Ames, David (1)
- Amin, Najaf (1)
- Anderson, Denise (1)
- Andlauer, Till (1)
- Andrade, Filipe (1)
- Andre, Aleman (1)
- Andreassen, Ole A. (1)
- Arias Vásquez, Alejandro (1)
- Armstrong, Nicola J. (1)
- Arveiler, Dominique (1)
- Assimes, Themistocles L. (1)
- Atalay, Mustafa (1)
- Attwood, Antony Paul (1)
- Aubé, Christophe (1)
- Babadjanova, Gulja (1)
- Badner, Judith A. (1)
- Bakker, Stephan J. L. (1)
- Barkhau, Carlotta (1)
- Barlassina, Cristina (1)
- Barrau, Caroline (1)
- Barrett, Thomas B. (1)
- Barroso, Inês (1)
- Basart, Hanneke (1)
- Bastin, Mark E. (1)
- Batalla, Albert (1)
- Bauer, Chris (1)
- Bauer, Christian (1)
- Bauer, David Josef Maria (1)
- Bauer, Hans Günther (1)
- Bauer, Jan (1)
- Bauer, Johann W. (1)
- Bauer, Karl (1)
- Bauer, Sabrina (1)
- Bauer, Stefan (1)
- Baur, Ramona (1)
- Bechdolf, Andreas (1)
- Becker, Tim (1)
- Beckmann, Jacques S. (1)
- Beilby, John P. (1)
- Benabarre Hernandez, Antonio (1)
- Benabarre, Antonio (1)
- Bendels, Michael Hans Karl (1)
- Bergen, Sarah E. (1)
- Bergo, Felipe (1)
- Bermpohl, Felix (1)
- Berndt, Christina (1)
- Berrettini, Wade H. (1)
- Berzigotti, Annalisa (1)
- Biederman, Joseph (1)
- Bielack, Stefan S. (1)
- Blaine, Sara K. (1)
- Blank, Bernd (1)
- Blanke, Julian (1)
- Bloss, Cinnamon S. (1)
- Boedhoe, Premika (1)
- Boehnke, Michael (1)
- Boesch, Maximilian (1)
- Bolton, Jennifer L. (1)
- Bonekamp, David (1)
- Bonnefond, Amélie (1)
- Bonnycastle, Lori L. (1)
- Boomsma, Dorret I. (1)
- Borecki, Ingrid B. (1)
- Bornstein, Stefan R. (1)
- Bose, Anushree (1)
- Boucher, Gabrielle (1)
- Boukouaci, Wahid (1)
- Boursier, Jerome (1)
- Bralten, Janita (1)
- Brandeis, Daniel (1)
- Brandts, Christian Hubertus (1)
- Breitenbach, Michael (1)
- Breitenbach-Koller, Lore (1)
- Brem, Silvia (1)
- Brennan, Paul E. (1)
- Brodaty, Henry (1)
- Brol, Maximilian (1)
- Brooks, Samantha J. (1)
- Brors, Benedikt (1)
- Brosch, Katharina (1)
- Bröckel, Kyra (1)
- Bröhl, Henrieke (1)
- Brüggmann, Dörthe (1)
- Buechler, Christa (1)
- Bui, Elise T. (1)
- Buitelaar, Jan K. (1)
- Busatto Filho, Geraldo (1)
- Byerley, William (1)
- Böhles, Hansjosef (1)
- Böhm, Bernhard O. (1)
- Bøen, Erlend (1)
- Bülow, Robin (1)
- Bürger, Christian (1)
- Calhoun, Vince D. (1)
- Calvo, Anna (1)
- Campbell, Harry (1)
- Canales-Rodrı́guez, Erick Jorge (1)
- Canive, Jose M. (1)
- Cannon, Dara M. (1)
- Caparelli, Elisabeth C. (1)
- Cassinotto, Christophe (1)
- Castellanos, Francisco X. (1)
- Castera, Laurent (1)
- Caulfield, Mark J. (1)
- Cavalleri, Gianpiero L. (1)
- Cearns, Micah (1)
- Cendes, Fernando (1)
- Cervenka, Simon (1)
- Cesana, Giancarlo (1)
- Chaim-Avancini, Tiffany Moukbel (1)
- Chang, Johannes (1)
- Chanock, Stephen J. (1)
- Chantiluke, Kaylita (1)
- Chasman, Daniel I. (1)
- Chen, Hsi-Chung (1)
- Chen, Qun-lin (1)
- Chen, Xiayu (1)
- Chen, Yii-Der Ida (1)
- Cheng, Yuqi (1)
- Chines, Peter S. (1)
- Christakou, Anastasia (1)
- Chuchalin, Alexander (1)
- Chudasama, Priya (1)
- Clark, Scott R. (1)
- Clark, Vincent P. (1)
- Clegg, Deborah J. (1)
- Coghill, David (1)
- Collins, Francis S. (1)
- Collste, Karin (1)
- Connolly, Colm G. (1)
- Conzelmann, Annette (1)
- Correll, Christoph U. (1)
- Coryell, William (1)
- Cousijn, Janna (1)
- Craig, David W. (1)
- Crivello, Fabrice (1)
- Croteau-Chonka, Damien C. (1)
- Crow, Tim (1)
- Cubillo, Ana (1)
- Cupples, L. Adrienne (1)
- Cόrdova-Palomera, Aldo (1)
- Dalkner, Nina (1)
- Davis, Tony (1)
- Day, Felix R. (1)
- De Ledinghen, Victor (1)
- De Zubicaray, Greig (1)
- Deary, Ian J. (1)
- Dedoussis, George (1)
- Delanty, Norman (1)
- Deloukas, Panos (1)
- Demeter, Damion V. (1)
- Dermitzakis, Emmanouil T. (1)
- Di Martino, Adriana (1)
- Dickie, Erin W (1)
- Dietsche, Bruno (1)
- Dimas, Antigone S. (1)
- Dimitriou, Maria (1)
- Doan, N. Trung (1)
- Doherty, Colin P. (1)
- Dohm, Katharina (1)
- Doyle, Alysa (1)
- Duijn, Cornelia M. van (1)
- Dumortier, Jerome (1)
- Durston, Sarah (1)
- Döll, Petra (1)
- Earl, Eric (1)
- Edenberg, Howard J. (1)
- Edkins, Sarah (1)
- Ehrlich, Stefan (1)
- Eijk, Liza van (1)
- Eils, Roland (1)
- Eisinger, Kristina (1)
- Eklund, Niina (1)
- Ekman, Carl Johan (1)
- Elvsåshagen, Torbjørn (1)
- Engberg, Goran (1)
- Epstein, Jeffery N. (1)
- Erbel, Raimund (1)
- Erdmann, Jeanette (1)
- Erhardt, Sophie (1)
- Eriksson, Johan G. (1)
- Ernsting, Jan (1)
- Esko, Tõnu (1)
- Estrada, Karol (1)
- Ethofer, Thomas (1)
- Fair, Damien A. (1)
- Faire, Ulf de (1)
- Falkenberg, Dania Irina (1)
- Fall, Tove (1)
- Fallgatter, Andreas J. (1)
- Faraone, Stephen V. (1)
- Farde, Lars (1)
- Farrall, Martin (1)
- Fatouros-Bergman, Helena (1)
- Faust, Michael (1)
- Feitosa, Mary F. (1)
- Ferensztajn-Rochowiak, Ewa (1)
- Fernndez, Guillen (1)
- Ferreira, Teresa (1)
- Ferstl, Philip (1)
- Fiebig, Jana (1)
- Fier, Heide (1)
- Fisch, Lukas (1)
- Fischer, Krista (1)
- Fischer, Sascha B. (1)
- Fisher, Simon E. (1)
- Flasbeck, Vera (1)
- Flinkenflügel, Kira (1)
- Flyckt, Lena (1)
- Foroud, Tatiana (1)
- Forster, Katharina (1)
- Fowkes, Gerry (1)
- Fox, Caroline S. (1)
- Foxe, John J. (1)
- Francks, Clyde (1)
- Francque, Sven (1)
- Franke, Barbara (1)
- Franks, Paul W. (1)
- Fraser, Ross M. (1)
- Frayling, Timothy (1)
- Freitag, Christine M. (1)
- Friedrich-Rust, Mireen (1)
- Frisen, Louise (1)
- Frisén, Louise (1)
- Froguel, Philippe (1)
- Fröhlich, Martina (1)
- Fröhling, Stefan (1)
- Fröhner, Juliane Hilde (1)
- Frölich, Lutz (1)
- Fuchs, Jörg (1)
- Fuentes-Claramonte, Paola (1)
- Fusch, Christoph (1)
- Ganna, Andrea (1)
- Garavan, Hugh (1)
- Garcia, Danielle do Santos (1)
- Geburtig-Chiocchetti, Andreas (1)
- Gejman, Pablo V. (1)
- Gershon, Elliot S. (1)
- Gertz, Hermann-Josef (1)
- Gieger, Christian (1)
- Gieldon, Laura (1)
- Gigante, Bruna (1)
- Glahn, David C. (1)
- Glimm, Hanno (1)
- Goel, Anuj (1)
- Goltermann, Janik (1)
- Gordon, Scott D. (1)
- Gotlib, Ian H. (1)
- Gottfriedovà, Halima (1)
- Goudriaan, Anna E. (1)
- Grabe, Hans Jörgen (1)
- Grallert, Harald (1)
- Greenwood, Tiffany A. (1)
- Grgurevic, Ivica (1)
- Groenewold, Nynke A. (1)
- Grof, Paul (1)
- Groneberg, Jan David Alexander (1)
- Groop, Leif C. (1)
- Groth, Marie (1)
- Groß, Joachim (1)
- Gruber, Marius (1)
- Grönberg, Henrik (1)
- Gröschel, Stefan (1)
- Gu, Wenyi (1)
- Guadalupe, Tulio (1)
- Guibal, Aymeric (1)
- Guillaud, Olivier (1)
- Gurholt, Tiril (1)
- Gustafsson, Stefan (1)
- Gyllensten, Ulf (1)
- Göttig, Stephan (1)
- Haavik, Jan (1)
- Hall, Alistair S. (1)
- Hall, Per (1)
- Hallmans, Göran (1)
- Hallmen, Erika (1)
- Hamsten, Anders (1)
- Hansell, Narelle K. (1)
- Haritunians, Talin (1)
- Harris, Mathew A. (1)
- Harris, Tamara B. (1)
- Harst, Pim van der (1)
- Hartikainen, Anna-Liisa (1)
- Hartman, Catharina (1)
- Hartwig, Maite (1)
- Hashimoto, Ryota (1)
- Haslinger, Denise (1)
- Hautzinger, Martin (1)
- Hayward, Caroline (1)
- Heard-Costa, Nancy L. (1)
- Hecker, Julian (1)
- Hedberg, Mikael (1)
- Heid, Iris M. (1)
- Heijer, Martin den (1)
- Heilig, Christoph E. (1)
- Heilmann-Heimbach, Stefanie (1)
- Heindel, Walter (1)
- Heining, Christoph (1)
- Hengstenberg, Christian (1)
- Henn, Fritz (1)
- Henschler, Reinhard (1)
- Hernandez, Maria del Carmen Valdes (1)
- Heslenfeld, Dirk (1)
- Hester, Robert (1)
- Heuser, Isabella (1)
- Hibar, Derrek Paul (1)
- Hicks, Andrew A. (1)
- Hingorani, Aroon (1)
- Hintner, Helmut (1)
- Hipolito, Maria (1)
- Hirschhorn, Joel N. (1)
- Hitturlingappa, Shashi (1)
- Ho, Beng-Choon (1)
- Ho, Tiffany C. (1)
- Hoekstra, Pieter J. (1)
- Hofman, Albert (1)
- Hofmann, Stefan G. (1)
- Hoogman, Martine (1)
- Horak, Peter (1)
- Hottenga, Jouke-Jan (1)
- Hovik, Marie F. (1)
- Hovingh, Kees G. (1)
- Howells, Fleur M. (1)
- Hsu, Yi-Hsiang (1)
- Hugdahl, Kenneth (1)
- Hui, Jennie (1)
- Huikuri, Heikki (1)
- Hultman, Christina M. (1)
- Humphries, Steve E. (1)
- Hung, Joseph (1)
- Hunter, David (1)
- Hutter, Barbara (1)
- Huyser, Chaim (1)
- Hveem, Kristian (1)
- Hyppönen, Elina (1)
- Hübschmann, Daniel (1)
- Hüll, Michael (1)
- I. Berndt, Sonja (1)
- Illig, Thomas (1)
- Ingelsson, Erik (1)
- Ingvar, Martind (1)
- Iribarren, Carlos (1)
- Irwin, Lourdes (1)
- Ishikawa, Akari (1)
- Jackson, Anne U. (1)
- Jacobs, Kevin B. (1)
- Jacoby, Harald (1)
- Jahanshad, Neda (1)
- Jahn, Holger (1)
- Jahnukainen, Kirsi (1)
- Jamalabadi, Hamidreza (1)
- James, Anthony (1)
- Jansen, Chrisitan (1)
- Jarvelin, Marjo-Riitta (1)
- Jean-Paul, Fouche (1)
- Jernigan, Terry L. (1)
- Jessen, Frank (1)
- Jochum, Frank (1)
- Johansson, Åsa (1)
- Johnson, Toby (1)
- Jolley, Jennifer (1)
- Juckel, Georg (1)
- Jula, Antti (1)
- Jung, Stine (1)
- Jönsson, Erik G. (1)
- Kahler, Claas (1)
- Kaleda, Vasily (1)
- Kalle, Christof von (1)
- Kalle, Thekla von (1)
- Kammerer-Ciernioch, Jutta (1)
- Kanoni, Stavroula (1)
- Kaplan, Robert (1)
- Kaprio, Jaakko (1)
- Karl, Thomas (1)
- Karpe, Fredrik (1)
- Kathiresan, Sekar (1)
- Kato, Tadafumi (1)
- Kazanowska, Bernarda (1)
- Kegel, Thomas (1)
- Keinanen-Kiukaanniemi, Sirkka M. (1)
- Kellermann, Josef (1)
- Kelly, Clare (1)
- Kerich, Michael (1)
- Keshavan, Matcheri S (1)
- Khadka, Sabin (1)
- Khaw, Kay-Tee (1)
- Khusnutdinova, Elza (1)
- Kiemeney, Lambertus Adrianus (1)
- Kilpeläinen, Tuomas O. (1)
- Kivimaki, Mika (1)
- Kjaergaard, Maria (1)
- Klauck, Sabine M. (1)
- Klauw, Melanie M. van der (1)
- Kleber, Marcus E. (1)
- Kleber, Sascha (1)
- Kleinheinz, Kortine (1)
- Klingebiel, Thomas (1)
- Klingelhöfer, Doris (1)
- Klink, Barbara (1)
- Kliwicki, Sebastian (1)
- Knuth, Alexander (1)
- Koenig, Wolfgang (1)
- Kogevinas, Manolis (1)
- Kohls, Gregor (1)
- Koletzko, Berthold (1)
- Koller, Daniel L. (1)
- Kolovou, Genovefa (1)
- Kong, Xiang-Zhen (1)
- Konrad, Kerstin (1)
- Kontny, Udo (1)
- Kornhuber, Johannes (1)
- Korucuoglu, Ozlem (1)
- Koscielniak, Ewa (1)
- Kovacs, Peter (1)
- Kraft, Vivien (1)
- Krag, Aleksander (1)
- Kraja, Aldi T. (1)
- Kramm, Christof M. (1)
- Krasnov, Valery (1)
- Krawinkel, Michael (1)
- Kristiansson, Kati (1)
- Krjutškov, Kaarel (1)
- Krohn, Jon P. (1)
- Krohn, Kathrin (1)
- Krug, Axel (1)
- Krämer, Bernd (1)
- Krämer, Stephen (1)
- Kuh, Diana (1)
- Kumari, Meena (1)
- Kuo, Po-Hsiu (1)
- Kurz, Alexander (1)
- Kusumi, Ichiro (1)
- Kutalik, Zoltán (1)
- Kuulasmaa, Kari (1)
- Kuusisto, Johanna (1)
- Kwon, Jun Soo (1)
- Laakso, Markku (1)
- Lackner, Nina (1)
- Lacour, André (1)
- Ladenstein, Ruth (1)
- Lakka, Timo A. (1)
- Lambert, Martin (1)
- Lambregts-Rommelse, Nanda (1)
- Lamina, Claudia (1)
- Lang, Maren (1)
- Langenberg, Claudia (1)
- Laprise, Catherine (1)
- Lawson, William B. (1)
- Le Clerc, Sigrid (1)
- Le Corvoisier, Philippe (1)
- Lebedeva, Irina (1)
- Leber, Markus (1)
- Leehr, Elisabeth Johanna (1)
- Leenings, Ramona (1)
- Lehtimäki, Terho (1)
- Lenroot, Rhoshel (1)
- Leopold, Karolina (1)
- Lesch, Klaus-Peter J. (1)
- Lewczuk, Piotr (1)
- Li, Guo (1)
- Li, Qinqin (1)
- Li, Shengxu (1)
- Liang, Liming (1)
- Liewen, Heike (1)
- Lim, Kelvin O. (1)
- Lind, Lars (1)
- Lindgren, Cecilia M. (1)
- Lindström, Jaana (1)
- Lissowska, Jolanta (1)
- Liu, Chunyu (1)
- Liu, Jia (1)
- Ljungman, Gustaf (1)
- Lochner, Christine (1)
- Locke, Adam E. (1)
- Lokki, Marja-Liisa (1)
- Loley, Christina (1)
- Lombardi, Laura (1)
- London, Edythe D. (1)
- Lonning, Vera (1)
- Loos, Ruth J. F. (1)
- Lorentzon, Mattias (1)
- Lorenzetti, Valentina (1)
- Lottspeich, Friedrich (1)
- Lu, Xue (1)
- Luan, Jian'an (1)
- Lucae, Susanne (1)
- Luciano, Michelle (1)
- Luckhaus, Christian (1)
- Luijten, Maartje (1)
- Lundervold, Astri J. (1)
- Lázaro, Luisa (1)
- Löffler, Herbert (1)
- MacMaster, Frank P. (1)
- Mackey, Scott (1)
- Magnusson, Patrik K. E. (1)
- Mahon, Pamela B. (1)
- Maingault, Sophie (1)
- Malmqvist, Anna (1)
- Malpas, Charles B. (1)
- Malt, Ulrik F. (1)
- Mangino, Massimo (1)
- Maniega, Susana Munoz (1)
- Margini, Cristina (1)
- Markuly, Norbert (1)
- Marschal, Oliver (1)
- Martin-Santos, Rocio (1)
- Marxen, Michael (1)
- Maschio, Andrea (1)
- Mataix-Cols, David (1)
- Mateo Leach, Irene (1)
- Mathias, Samuel R. (1)
- Mathieson, Iain (1)
- Mattheisen, Manuel (1)
- Matura, Silke (1)
- Mayer, Andrew R. (1)
- Mayoral, Fermı́n (1)
- Mazoyer, Bernard (1)
- McArdle, Wendy L. (1)
- McCarthy, Hazel (1)
- McCarthy, Mark I. (1)
- McDonald, Colm (1)
- McElroy, Susan (1)
- McElroy, Susan L. (1)
- McInnis, Melvin G. (1)
- McKay, James D. (1)
- McKinney, Rebecca (1)
- McLellan, Quinn (1)
- McMahon, Katie L. (1)
- McPhilemy, Genevieve (1)
- Medina-Gomez, Carolina (1)
- Meer, Dennis van der (1)
- Meier, Sandra (1)
- Meinert, Susanne (1)
- Metspalu, Andres (1)
- Mihailov, Evelin (1)
- Mika, Jagoda (1)
- Mikolas, Pavol (1)
- Millischer, Vincent (1)
- Min, Josine L. (1)
- Mischo, Axel (1)
- Mohlke, Karen L. (1)
- Momenan, Reza (1)
- Monda, Keri L. (1)
- Morales, Angelica M. (1)
- Moreira, José Carlos Vasques (1)
- Morris, Andrew David (1)
- Mueller, Bryon A. (1)
- Munroe, Patricia B. (1)
- Mustapic, Sanda (1)
- Mägi, Reedik (1)
- März, Winfried (1)
- Mörtl, Martin (1)
- Mühlebach, Stefan (1)
- Müller, Dirk K. (1)
- Müller-Myhsok, Bertram (1)
- Müller-Nurasyid, Martina (1)
- Münter, Marc (1)
- Narayanaswamy, Janardhanan C. (1)
- Narisu, Narisu (1)
- Navis, Gerjan (1)
- Nenadić, Igor (1)
- Nerland, Stener (1)
- Nestor, Liam (1)
- Nicholson, George (1)
- Nigg, Joel T. (1)
- Niggli, Felix (1)
- Nitsch, Robert (1)
- Njølstad, Inger (1)
- Nolte, Ilja M. (1)
- Nordvik, Jan-Egil (1)
- North, Kari E. (1)
- Novotny, Stephanie (1)
- Nurnberger, John I. (1)
- Nwulia, Evaristus A. (1)
- O'Connell, Jeffrey R. (1)
- O'Donovan, Claire (1)
- Oberwelland, Eileen (1)
- Ohlsson, Claes (1)
- Ong, Ken K. (1)
- Oosterlaan, Jaap (1)
- Oostra, Ben A. (1)
- Opel, Nils (1)
- Oranje, Bob (1)
- Orhan, Funda (1)
- Orr, Catherine (1)
- Overs, Bronwyn (1)
- Ozaki, Norio (1)
- O’Gorman, Ruth L. (1)
- Palmer, Colin N. A. (1)
- Palmer, Lyle J. (1)
- Pantel, Johannes (1)
- Pantelejeva, Galina (1)
- Papiol, Sergi (1)
- Pauli, Paul (1)
- Paulus, Martin (1)
- Pechlivanis, Sonali (1)
- Pedersen, Nancy L. (1)
- Penninx, Brenda W. J. H. (1)
- Penzel, Roland (1)
- Perola, Markus (1)
- Person, Thomas (1)
- Peters, Annette (1)
- Peters, Oliver (1)
- Pfarr, Julia-Katharina (1)
- Pfütze, Katrin (1)
- Piehl, Fredrik (1)
- Pisanu, Claudia (1)
- Plessen, Kerstin (1)
- Pol, Stanislas (1)
- Polier, Georg von (1)
- Polonikov, Alexey (1)
- Pomarol-Clotet, Edith (1)
- Popescu, Alina (1)
- Portmann, Felix Theodor (1)
- Poustka, Fritz (1)
- Power, Chris (1)
- Praktiknjo, Michael (1)
- Pramstaller, Peter P. (1)
- Price, Jackie F. (1)
- Prokopenko, Inga (1)
- Propping, Peter (1)
- Province, Michael A. (1)
- Qi, Lu (1)
- Qiu, Jiang (1)
- Radua, Joaquim (1)
- Raimondi, Francesco (1)
- Raitakari, Olli (1)
- Ramos-Quiroga, J. Antoni (1)
- Randall, Joshua C. (1)
- Rasmussen, Ditlev Nytoft (1)
- Rau, Anne Katrin (1)
- Rauramaa, Rainer (1)
- Rautou, Pierre Emmanuel (1)
- Reddy, Y.C. Janardhan (1)
- Redlich, Ronny (1)
- Rehnberg, Emil (1)
- Reiberger, Thomas (1)
- Reinbold, Céline S. (1)
- Reischies, Friedel (1)
- Reisinger, Eva (1)
- Renner, Christoph (1)
- Repple, Jonathan (1)
- Rice, John (1)
- Richard, Jean-Romain (1)
- Richter, Daniela (1)
- Richter, Stephan (1)
- Ridker, Paul M. (1)
- Rienhoff, Otto (1)
- Ripatti, Samuli (1)
- Ritter, Philipp Stefan (1)
- Rivadeneira, Fernando (1)
- Rivas, Fabio (1)
- Rivolta, Carlo (1)
- Roberts, Gloria (1)
- Rolle, Stefan (1)
- Ronot, Maxime (1)
- Rosa, Pedro (1)
- Rose, Lynda M. (1)
- Rubia, Katya (1)
- Rudan, Igor (1)
- Russell, Robert B. (1)
- Rüther, Eckart (1)
- Saaristo, Timo E. (1)
- Sacchet, Matthew D. (1)
- Sachdev, Perminder S. (1)
- Sager, Hendrik (1)
- Salomaa, Veikko (1)
- Salvador, Raymond (1)
- Samani, Nilesh J. (1)
- Sambrook, Jennifer G. (1)
- Saramies, Jouko (1)
- Sarink, Kelvin (1)
- Saud, Alhusaini (1)
- Sauer, Cathrin (1)
- Scheer, Monika (1)
- Scheftner, William A. (1)
- Scheibe, Burghardt (1)
- Schenk, Lorena M. (1)
- Scherag, André (1)
- Schlegel, Paul-Gerhardt (1)
- Schlenk, Richard Friedrich (1)
- Schlesner, Matthias (1)
- Schlessinger, David (1)
- Schmaal, Lianne (1)
- Schmieder, Klaus (1)
- Scholl, Claudia (1)
- Schork, Nicholas J. (1)
- Schröck, Evelin (1)
- Schröder, Johannes (1)
- Schubert, Klaus Oliver (1)
- Schuchhardt, Johannes (1)
- Schulz, Martin (1)
- Schunkert, Heribert (1)
- Schwarz, Markus (1)
- Schwarz, Peter E. H. (1)
- Schweren, Lisanne (1)
- Schwieler, Lilly (1)
- Schöffel, Norman (1)
- Seidman, Larry J. (1)
- Seitz, Jochen (1)
- Semmler, Georg (1)
- Senkerikova, Renata (1)
- Serpa, Mauricio Henriques (1)
- Shaw, Philip (1)
- Shi, Jianxin (1)
- Shimoda, Katzutaka (1)
- Shuldiner, Alan R. (1)
- Shumskaya, Elena (1)
- Shungin, Dmitry (1)
- Siebert, Stefan (1)
- Silk, Timothy J. (1)
- Simbrunner, Benedikt Michael (1)
- Simmons, Alan N. (1)
- Simulionyte, Egle (1)
- Sinha, Rajita (1)
- Sinisalo, Juha (1)
- Sivalingam, Sugirthan (1)
- Sjoerds, Zsuzsika (1)
- Smelror, Runar Elle (1)
- Smith, Albert Vernon (1)
- Smith, Erin N. (1)
- Snieder, Harold (1)
- Soliva, Joan Carlos (1)
- Solowij, Nadia (1)
- Song, Jie (1)
- Spadoni, Jean-Louis (1)
- Sparber‐Sauer, Monika (1)
- Spector, Tim D. (1)
- Speliotes, Elizabeth K. (1)
- Sponheim, Scott R. (1)
- Sporea, Ioan (1)
- Spriewald, Bernd (1)
- Stark, Herbert (1)
- Stefansson, Kari (1)
- Stein, Dan J. (1)
- Stein, Elliot A. (1)
- Stein, Frederike (1)
- Steinthorsdottir, Valgerdur (1)
- Stenner, Frank (1)
- Stenzinger, Albrecht (1)
- Stevens, Michael (1)
- Stirrups, Kathleen (1)
- Strachan, David P. (1)
- Straube, Benjamin (1)
- Strawbridge, Rona J. (1)
- Straßburg, Christian P. (1)
- Strike, Lachlan T. (1)
- Sudre, Gustavo (1)
- Sui, Jing (1)
- Surakka, Ida (1)
- Swift, Amy J. (1)
- Szelinger, Szabolcs (1)
- Szeszenia-Dabrowska, Neonila (1)
- Tamm, Leanne (1)
- Tamouza, Ryad (1)
- Teder-Laving, Maris (1)
- Teipel, Stefan (1)
- Tekola-Ayele, Fasil (1)
- Temmingh, Hendrik S. (1)
- Teumer, Alexander (1)
- Teutenberg, Lea (1)
- Thiel, Katharina (1)
- Thiele, Maja (1)
- Thoma, Robert J. (1)
- Thomas-Odenthal, Florian (1)
- Thompson, Paul M. (1)
- Thorand, Barbara (1)
- Thorleifsson, Gudmar (1)
- Thorsteinsdottir, Unnur (1)
- Tiganov, Alexander S. (1)
- Tighe, Sarah K. (1)
- Tjesic Drinkovic, Ida (1)
- Tomyshev, Alexander S. (1)
- Trebicka, Jonel (1)
- Tremoli, Elena (1)
- Treutlein, Jens (1)
- Tronchin, Giulia (1)
- Tuomilehto, Jaakko (1)
- Turner, Jessica A. (1)
- Tyrer, Jonathan (1)
- Tzourio-Mazoyer, Nathalie (1)
- Tönjes, Anke (1)
- Uhlmann, Anne (1)
- Uhrig, Sebastian (1)
- Uitterlinden, André G. (1)
- Uschner, Frank Erhard (1)
- Usemann, Paula (1)
- Uusitupa, Matti (1)
- Vance, Alasdair (1)
- Vanwolleghem, Thomas (1)
- Vassord, Camille (1)
- Vedantam, Sailaja (1)
- Vedder, Helmut (1)
- Veeh, Julia (1)
- Veer, Ilya M. (1)
- Veltman, Dick J. (1)
- Venkatasubramanian, Ganesan (1)
- Victorsson, Pauliina (1)
- Vilarroya, Oscar (1)
- Vilgrain, Valerie (1)
- Virtamo, Jarmo (1)
- Vives-Gilabert, Yolanda (1)
- Vliet-Ostaptchouk, Jana V. van (1)
- Vogelbacher, Christoph (1)
- Voineskos, Aristotle N. (1)
- Vokuhl, Christian (1)
- Volkert, Julia (1)
- Vonghia, Luisa (1)
- Vuletic, Daniella (1)
- Wadle, Andreas (1)
- Wagner, Michael (1)
- Waite, Lindsay L. (1)
- Walitza, Susanne (1)
- Walter, Henrik (1)
- Walton, Esther (1)
- Wang, Wenping (1)
- Wang, Zhaoming (1)
- Wardlaw, Joanna M. (1)
- Wareham, Nicholas J. (1)
- Warsow, Gregor (1)
- Weichert, Wilko (1)
- Wen, Wei (1)
- Werner, Stefan (1)
- Wessalowski, Rüdiger (1)
- Westlye, Lars T. (1)
- Whelan, Christopher D. (1)
- White, Tonya (1)
- Wichmann, Heinz Erich (1)
- Wiemann, Stefan (1)
- Wiers, Reinout W. (1)
- Wilsgaard, Tom (1)
- Wilson, James F. (1)
- Wiltfang, Jens (1)
- Winkelmann, Bernhard R. (1)
- Winkler, Thomas W. (1)
- Winter, Alexandra (1)
- Winter, Nils R. (1)
- Witt, Stephanie (1)
- Wittfeld, Katharina (1)
- Wolf, Stefanie (1)
- Wolf, Stephan (1)
- Wong, Andrew (1)
- Wood, Andrew R. (1)
- Workalemahu, Tsegaselassie (1)
- Wright, Margaret J. (1)
- Wroblewski, Adrian (1)
- Yang, Jian (1)
- Yang, Tony T. (1)
- Yarnell, John W. G. (1)
- Yasuda, Clarissa L. (1)
- Yoncheva, Yuliya (1)
- Yucel, Murat (1)
- Yun, Je-Yeon (1)
- Zagury, Jean-François (1)
- Zanetti, Marcus Vinicius (1)
- Zeeuw, Patrick de (1)
- Zeuzem, Stefan (1)
- Zhang, Peng (1)
- Zhao, Jing Hua (1)
- Zhen, Zonglei (1)
- Zheng, Rongqin (1)
- Zhu, Xing-xing (1)
- Ziegler, Georg Christoph (1)
- Zierhut, Kathrin (1)
- Zillikens, M. Carola (1)
- Zollner, Sebastian (1)
- Zweifel, Martin (1)
- Zwiers, Marcel P. (1)
- de Bruttopilo, Sara Ambrosino (1)
- van Erp, Theo G.M. (1)
- van Holst, Ruth J. (1)
- van den Heuvel, Odile (1)
Year of publication
Document Type
- Article (12)
- Preprint (3)
- Book (1)
- Working Paper (1)
Has Fulltext
- yes (17)
Is part of the Bibliography
- no (17)
Keywords
- Alzheimer’s dementia (1)
- Amyloid-beta 42 (1)
- Australia (1)
- Biomarkers (1)
- Bipolar disorder (1)
- Bodensee (1)
- Bodensee-Gebiet (1)
- Canada (1)
- Cancer (1)
- Cancer genetics (1)
Institute
- Medizin (15)
- Geowissenschaften (1)
A data set of monthly growing areas of 26 irrigated crops (MGAG-I) and related crop calendars (CC-I) was compiled for 402 spatial entities. The selection of the crops consisted of all major food crops including regionally important ones (wheat, rice, maize, barley, rye, millet, sorghum, soybeans, sunflower, potatoes, cassava, sugar cane, sugar beets, oil palm, rapeseed/canola, groundnuts/peanuts, pulses, citrus, date palm, grapes/vine, cocoa, coffee), major water-consuming crops (cotton), and unspecified other crops (other perennial crops, other annual crops, managed grassland). The data set refers to the time period 1998-2002 and has a spatial resolution of 5 arc minutes by 5 arc minutes which is 8 km by 8 km at the equator. This is the first time that a data set of cell-specific irrigated growing areas of irrigated crops with this spatial resolution was created. The data set is consistent to the irrigated area and water use statistics of the AQUASTAT programme of the Food and Agriculture Organization of the United Nations (FAO) (http://www.fao.org/ag/agl/aglw/aquastat/main/index.stm) and the Global Map of Irrigation Areas (GMIA) (http://www.fao.org/ag/agl/aglw/aquastat/irrigationmap/index.stm). At the cell-level it was tried to maximise consistency to the cropland extent and cropland harvested area from the Department of Geography and Earth System Science Program of the McGill University at Montreal, Quebec, Canada and the Center for Sustainability and the Global Environment (SAGE) of the University of Wisconsin at Madison, USA (http://www.geog.mcgill.ca/~nramankutty/ Datasets/Datasets.html and http://geomatics.geog.mcgill.ca/~navin/pub/Data/175crops2000/). The consistency between the grid product and the input data was quantified. MGAG-I and CC-I are fully consistent to each other on entity level. For input data other than CC-I, the consistency of MGAG-I on cell level was calculated. The consistency of MGAG-I with respect to the area equipped for irrigation (AEI) of GMIA and to the cropland extent of SAGE was characterised by the sum of the cell-specific maximum difference between the MGAG-I monthly total irrigated area and the reference area when the latter was exceeded in the grid cell. The consistency of the harvested area contained in MGAG-I with respect to SAGE harvested area was characterised by the crop-specific sum of the cell-specific difference between MGAG-I harvested area and the SAGE harvested area when the latter was exceeded in the grid cell. In all three cases, the sums are the excess areas that should not have been distributed under the assumption that the input data were correct. Globally, this cell-level excess of MGAG-I as compared to AEI is 331,304 ha or only about 0.12 % of the global AEI of 278.9 Mha found in the original grid. The respective cell-level excess of MGAG-I as compared to the SAGE cropland extent is 32.2 Mha, corresponding to about 2.2 % of the total cropland area. The respective cell-level excess of MGAG-I as compared to the SAGE harvested area is 27 % of the irrigated harvested area, or 11.5 % of the AEI. In a further step that will be published later also rainfed areas were compiled in order to form the Global data set of monthly irrigated and rainfed crop areas around the year 2000 (MIRCA2000). The data set can be used for global and continental-scale studies on food security and water use. In the future, it will be improved, e.g. with a better spatial resolution of crop calendars and an improved crop distribution algorithm. The MIRCA2000 data set, its full documentation together with future updates will be freely available through the following long-term internet site: http://www.geo.uni-frankfurt.de/ipg/ag/dl/forschung/MIRCA/index.html. The research presented here was funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) within the framework of the research project entitled "Consistent assessment of global green, blue and virtual water fluxes in the context of food production: regional stresses and worldwide teleconnections". The authors thank Navin Ramankutty and Chad Monfreda for making available the current SAGE datasets on cropland extent (Ramankutty et al., 2008) and harvested area (Monfreda et al., 2008) prior to their publication.
Forstner, Andreas Josef ; Hecker, Julian ; Hofmann, Andrea ; Maaser, Anna ; Reinbold, Céline S. ; Mühleisen, Thomas W. ; Leber, Markus ; Strohmaier, Jana ; Degenhardt, Franziska ; Treutlein, Jens ; Mattheisen, Manuel ; Schumacher, Johannes ; Streit, Fabian ; Meier, Sandra ; Herms, Stefan ; Hoffmann, Per ; Lacour, André ; Witt, Stephanie ; Reif, Andreas ; Müller-Myhsok, Bertram ; Lucae, Susanne ; Maier, Wolfgang ; Schwarz, Markus ; Vedder, Helmut ; Kammerer-Ciernioch, Jutta ; Pfennig, Andrea ; Bauer, Michael ; Hautzinger, Martin ; Moebus, Susanne ; Schenk, Lorena M. ; Fischer, Sascha B. ; Sivalingam, Sugirthan ; Czerski, Piotr M. ; Hauser, Joanna ; Lissowska, Jolanta ; Szeszenia-Dabrowska, Neonila ; Brennan, Paul E. ; McKay, James D. ; Wright, Adam ; Mitchell, Philip B. ; Fullerton, Janice M. ; Schofield, Peter R. ; Montgomery, Grant W. ; Medland, Sarah E. ; Gordon, Scott D. ; Martin, Nicholas Gordon ; Krasnov, Valery ; Chuchalin, Alexander ; Babadjanova, Gulja ; Pantelejeva, Galina ; Abramova, Lilia I. ; Tiganov, Alexander S. ; Polonikov, Alexey ; Khusnutdinova, Elza ; Alda, Martin ; Cruceanu, Cristiana ; Rouleau, Guy A. ; Turecki, Gustavo ; Laprise, Catherine ; Rivas, Fabio ; Mayoral, Fermı́n ; Kogevinas, Manolis ; Grigoroiu-Serbanescu, Maria ; Becker, Tim ; Schulze, Thomas Gerd ; Rietschel, Marcella ; Cichon, Sven ; Fier, Heide ; Nöthen, Markus Maria
Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders.
Scheer, Monika ; Vokuhl, Christian ; Blank, Bernd ; Hallmen, Erika ; Kalle, Thekla von ; Münter, Marc ; Wessalowski, Rüdiger ; Hartwig, Maite ; Sparber‐Sauer, Monika ; Schlegel, Paul-Gerhardt ; Kramm, Christof M. ; Kontny, Udo ; Spriewald, Bernd ; Kegel, Thomas ; Bauer, Sebastian ; Kazanowska, Bernarda ; Niggli, Felix ; Ladenstein, Ruth ; Ljungman, Gustaf ; Jahnukainen, Kirsi ; Fuchs, Jörg ; Bielack, Stefan S. ; Klingebiel, Thomas ; Koscielniak, Ewa
Background: To evaluate optimal therapy and potential risk factors.
Methods: Data of DSRCT patients <40 years treated in prospective CWS trials 1997‐2015 were analyzed.
Results: Median age of 60 patients was 14.5 years. Male:female ratio was 4:1. Tumors were abdominal/retroperitoneal in 56/60 (93%). 6/60 (10%) presented with a localized mass, 16/60 (27%) regionally disseminated nodes, and 38/60 (63%) with extraperitoneal metastases. At diagnosis, 23/60 (38%) patients had effusions, 4/60 (7%) a thrombosis, and 37/54 (69%) elevated CRP. 40/60 (67%) patients underwent tumor resection, 21/60 (35%) macroscopically complete. 37/60 (62%) received chemotherapy according to CEVAIE (ifosfamide, vincristine, actinomycin D, carboplatin, epirubicin, etoposide), 15/60 (25%) VAIA (ifosfamide, vincristine, adriamycin, actinomycin D) and, 5/60 (8%) P6 (cyclophosphamide, doxorubicin, vincristine, ifosfamide, etoposide). Nine received high‐dose chemotherapy, 6 received regional hyperthermia, and 20 received radiotherapy. Among 25 patients achieving complete remission, 18 (72%) received metronomic therapies. Three‐year event‐free (EFS) and overall survival (OS) were 11% (±8 confidence interval [CI] 95%) and 30% (±12 CI 95%), respectively, for all patients and 26.7% (±18.0 CI 95%) and 56.9% (±20.4 CI 95%) for 25 patients achieving remission. Extra‐abdominal site, localized disease, no effusion or ascites only, absence of thrombosis, normal CRP, complete tumor resection, and chemotherapy with VAIA correlated with EFS in univariate analysis. In multivariate analysis, significant factors were no thrombosis and chemotherapy with VAIA. In patients achieving complete remission, metronomic therapy with cyclophosphamide/vinblastine correlated with prolonged time to relapse.
Conclusion: Pleural effusions, venous thrombosis, and CRP elevation were identified as potential risk factors. The VAIA scheme showed best outcome. Maintenance therapy should be investigated further.
Mikolas, Pavol ; Bröckel, Kyra ; Vogelbacher, Christoph ; Müller, Dirk K. ; Marxen, Michael ; Berndt, Christina ; Sauer, Cathrin ; Jung, Stine ; Fröhner, Juliane Hilde ; Fallgatter, Andreas J. ; Ethofer, Thomas ; Rau, Anne Katrin ; Kircher, Tilo ; Falkenberg, Dania Irina ; Lambert, Martin ; Kraft, Vivien ; Leopold, Karolina ; Bechdolf, Andreas ; Reif, Andreas ; Matura, Silke ; Stamm, Thomas ; Bermpohl, Felix ; Fiebig, Jana ; Juckel, Georg ; Flasbeck, Vera ; Correll, Christoph U. ; Ritter, Philipp Stefan ; Bauer, Michael ; Jansen, Andreas ; Pfennig, Andrea
In psychiatry, there has been a growing focus on identifying at-risk populations. For schizophrenia, these efforts have led to the development of early recognition and intervention measures. Despite a similar disease burden, the populations at risk of bipolar disorder have not been sufficiently characterized. Within the BipoLife consortium, we used magnetic resonance imaging (MRI) data from a multicenter study to assess structural gray matter alterations in N = 263 help-seeking individuals from seven study sites. We defined the risk using the EPIbipolar assessment tool as no-risk, low-risk, and high-risk and used a region-of-interest approach (ROI) based on the results of two large-scale multicenter studies of bipolar disorder by the ENIGMA working group. We detected significant differences in the thickness of the left pars opercularis (Cohen’s d = 0.47, p = 0.024) between groups. The cortex was significantly thinner in high-risk individuals compared to those in the no-risk group (p = 0.011). We detected no differences in the hippocampal volume. Exploratory analyses revealed no significant differences in other cortical or subcortical regions. The thinner cortex in help-seeking individuals at risk of bipolar disorder is in line with previous findings in patients with the established disorder and corresponds to the region of the highest effect size in the ENIGMA study of cortical alterations. Structural alterations in prefrontal cortex might be a trait marker of bipolar risk. This is the largest structural MRI study of help-seeking individuals at increased risk of bipolar disorder.
Trebicka, Jonel ; Gu, Wenyi ; De Ledinghen, Victor ; Aubé, Christophe ; Krag, Aleksander ; Praktiknjo, Michael ; Castera, Laurent ; Dumortier, Jerome ; Bauer, David Josef Maria ; Friedrich-Rust, Mireen ; Pol, Stanislas ; Grgurevic, Ivica ; Zheng, Rongqin ; Francque, Sven ; Gottfriedovà, Halima ; Mustapic, Sanda ; Sporea, Ioan ; Berzigotti, Annalisa ; Uschner, Frank Erhard ; Simbrunner, Benedikt Michael ; Ronot, Maxime ; Cassinotto, Christophe ; Kjaergaard, Maria ; Andrade, Filipe ; Schulz, Martin ; Semmler, Georg ; Tjesic Drinkovic, Ida ; Chang, Johannes ; Brol, Maximilian ; Rautou, Pierre Emmanuel ; Vanwolleghem, Thomas ; Straßburg, Christian P. ; Boursier, Jerome ; Ferstl, Philip ; Rasmussen, Ditlev Nytoft ; Reiberger, Thomas ; Vilgrain, Valerie ; Guibal, Aymeric ; Guillaud, Olivier ; Zeuzem, Stefan ; Vassord, Camille ; Lu, Xue ; Vonghia, Luisa ; Senkerikova, Renata ; Popescu, Alina ; Margini, Cristina ; Wang, Wenping ; Thiele, Maja ; Jansen, Chrisitan
Objective: Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients.
Design: This international multicentre cohort study included a derivation ACLD patient cohort with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical and laboratory parameters at baseline and during follow-up were recorded. LSM by transient elastography (TE) was also recorded if available. The primary outcome was overall mortality. The secondary outcome was the development of first/further decompensation.
Results: After screening 2148 patients (16 centres), 1827 patients (55 years, 62.4% men) were included in the 2D-SWE cohort, with median liver SWE (L-SWE) 11.8 kPa and a model for end stage liver disease (MELD) score of 8. Combination of MELD score and L-SWE predict independently of mortality (AUC 0.8). L-SWE cut-off at ≥20 kPa combined with MELD ≥10 could stratify the risk of mortality and first/further decompensation in ACLD patients. The 2-year mortality and decompensation rates were 36.9% and 61.8%, respectively, in the 305 (18.3%) high-risk patients (with L-SWE ≥20 kPa and MELD ≥10), while in the 944 (56.6%) low-risk patients, these were 1.1% and 3.5%, respectively. Importantly, this M10LS20 algorithm was validated by TE-based LSM and in an additional cohort of 119 patients with valid point shear SWE-LSM.
Conclusion: The M10LS20 algorithm allows risk stratification of patients with ACLD. Patients with L-SWE ≥20 kPa and MELD ≥10 should be followed closely and receive intensified care, while patients with low risk may be managed at longer intervals.
Hou, Liping ; Bergen, Sarah E. ; Akula, Nirmala ; Song, Jie ; Hultman, Christina M. ; Landén, Mikael ; Adli, Mazda ; Alda, Martin ; Ardau, Raffaella ; Arias, Bárbara ; Aubry, Jean-Michel ; Backlund, Lena ; Badner, Judith A. ; Barrett, Thomas B. ; Bauer, Michael ; Baune, Bernhard T. ; Bellivier, Frank ; Benabarre Hernandez, Antonio ; Bengesser, Susanne ; Berrettini, Wade H. ; Bhattacharjee, Abesh Kumar ; Biernacka, Joanna ; Birner, Armin ; Bloss, Cinnamon S. ; Brichant-Petitjean, Clara ; Bui, Elise T. ; Byerley, William ; Cervantes, Pablo ; Chillotti, Caterina ; Cichon, Sven ; Colom, Francesc ; Coryell, William ; Craig, David W. ; Cruceanu, Cristiana ; Czerski, Piotr M. ; Davis, Tony ; Dayer, Alexandre ; Degenhardt, Franziska ; Del Zompo, Maria ; DePaulo, J. Raymond ; Edenberg, Howard J. ; Étain, Bruno ; Falkai, Peter ; Foroud, Tatiana ; Forstner, Andreas Josef ; Frisén, Louise ; Frye, Mark A. ; Fullerton, Janice M. ; Gard, Sébastien ; Garnham, Julie S. ; Gershon, Elliot S. ; Goes, Fernando S. ; Greenwood, Tiffany A. ; Grigoroiu-Serbanescu, Maria ; Hauser, Joanna ; Heilbronner, Urs ; Heilmann-Heimbach, Stefanie ; Herms, Stefan ; Hipolito, Maria ; Hitturlingappa, Shashi ; Hoffmann, Per ; Hofmann, Andrea ; Jamain, Stephane ; Jiménez, Esther ; Kahn, Jean-Pierre ; Kassem, Layla ; Kelsoe, John R. ; Kittel-Schneider, Sarah ; Kliwicki, Sebastian ; Koller, Daniel L. ; König, Barbara ; Lackner, Nina ; Laje, Gonzalo ; Lang, Maren ; Lavebratt, Catharina ; Lawson, William B. ; Leboyer, Marion ; Leckband, Susan G. ; Liu, Chunyu ; Maaser, Anna ; Mahon, Pamela B. ; Maier, Wolfgang ; Maj, Mario ; Manchia, Mirko ; Martinsson, Lina ; McCarthy, Michael J. ; McElroy, Susan L. ; McInnis, Melvin G. ; McKinney, Rebecca ; Mitchell, Philip B. ; Mitjans, Marina ; Mondimore, Francis Mark ; Monteleone, Palmiero ; Mühleisen, Thomas W. ; Nievergelt, Caroline M. ; Nöthen, Markus Maria ; Novák, Tomas ; Nurnberger, John I. ; Nwulia, Evaristus A. ; Ösby, Urban ; Pfennig, Andrea ; Potash, James B. ; Propping, Peter ; Reif, Andreas ; Reininghaus, Eva ; Rice, John ; Rietschel, Marcella ; Rouleau, Guy A. ; Rybakowski, Janusz K. ; Schalling, Martin ; Scheftner, William A. ; Schofield, Peter R. ; Schork, Nicholas J. ; Schulze, Thomas Gerd ; Schumacher, Johannes ; Schweizer, Barbara W. ; Severino, Giovanni ; Shekhtman, Tatyana ; Shilling, Paul D. ; Simhandl, Christian ; Slaney, Claire M. ; Smith, Erin N. ; Squassina, Alessio ; Stamm, Thomas ; Stopkova, Pavla ; Streit, Fabian ; Strohmaier, Jana ; Szelinger, Szabolcs ; Tighe, Sarah K. ; Tortorella, Alfonso ; Turecki, Gustavo ; Vieta, Eduard ; Volkert, Julia ; Witt, Stephanie H. ; Wright, Adam ; Zandi, Peter P. ; Zhang, Peng ; Zollner, Sebastian ; McMahon, Francis J.
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the Xchromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87×10-9; odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53×10-9; odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
(2017)
Kong, Xiang-Zhen ; Mathias, Samuel R. ; Guadalupe, Tulio ; Abé, Christoph ; Agartz, Ingrid ; Akudjedu, Theophilus N. ; Andre, Aleman ; Saud, Alhusaini ; Allen, Nicholas B. ; Ames, David ; Andreassen, Ole A. ; Arias Vásquez, Alejandro ; Armstrong, Nicola J. ; Bergo, Felipe ; Bastin, Mark E. ; Batalla, Albert ; Bauer, Jochen ; Baune, Bernhard T. ; Baur, Ramona ; Biederman, Joseph ; Blaine, Sara K. ; Boedhoe, Premika ; Bøen, Erlend ; Bose, Anushree ; Bralten, Janita ; Brandeis, Daniel ; Brem, Silvia ; Brodaty, Henry ; Bröhl, Henrieke ; Brooks, Samantha J. ; Buitelaar, Jan K. ; Bürger, Christian ; Bülow, Robin ; Calhoun, Vince D. ; Calvo, Anna ; Canales-Rodrı́guez, Erick Jorge ; Canive, Jose M. ; Cannon, Dara M. ; Caparelli, Elisabeth C. ; Castellanos, Francisco X. ; Cavalleri, Gianpiero L. ; Cendes, Fernando ; Chaim-Avancini, Tiffany Moukbel ; Chantiluke, Kaylita ; Chen, Qun-lin ; Chen, Xiayu ; Cheng, Yuqi ; Christakou, Anastasia ; Clark, Vincent P. ; Coghill, David ; Connolly, Colm G. ; Conzelmann, Annette ; Cόrdova-Palomera, Aldo ; Cousijn, Janna ; Crow, Tim ; Cubillo, Ana ; Dannlowski, Udo ; de Bruttopilo, Sara Ambrosino ; Zeeuw, Patrick de ; Deary, Ian J. ; Delanty, Norman ; Demeter, Damion V. ; Di Martino, Adriana ; Dickie, Erin W ; Dietsche, Bruno ; Doan, N. Trung ; Doherty, Colin P. ; Doyle, Alysa ; Durston, Sarah ; Earl, Eric ; Ehrlich, Stefan ; Ekman, Carl Johan ; Elvsåshagen, Torbjørn ; Epstein, Jeffery N. ; Fair, Damien A. ; Faraone, Stephen V. ; Fatouros-Bergman, Helena ; Fernndez, Guillen ; Busatto Filho, Geraldo ; Flyckt, Lena ; Forster, Katharina ; Jean-Paul, Fouche ; Foxe, John J. ; Fuentes-Claramonte, Paola ; Fullerton, Janice M. ; Garavan, Hugh ; Garcia, Danielle do Santos ; Gotlib, Ian H. ; Goudriaan, Anna E. ; Grabe, Hans Jörgen ; Groenewold, Nynke A. ; Grotegerd, Dominik ; Gruber, Oliver ; Gurholt, Tiril ; Haavik, Jan ; Hahn, Tim ; Hansell, Narelle K. ; Harris, Mathew A. ; Hartman, Catharina ; Hernandez, Maria del Carmen Valdes ; Heslenfeld, Dirk ; Hester, Robert ; Hibar, Derrek Paul ; Ho, Beng-Choon ; Ho, Tiffany C. ; Hoekstra, Pieter J. ; van Holst, Ruth J. ; Hoogman, Martine ; Hovik, Marie F. ; Howells, Fleur M. ; Hugdahl, Kenneth ; Huyser, Chaim ; Ingvar, Martind ; Irwin, Lourdes ; Ishikawa, Akari ; James, Anthony ; Jahanshad, Neda ; Jernigan, Terry L. ; Jönsson, Erik G. ; Kahler, Claas ; Kaleda, Vasily ; Kelly, Clare ; Kerich, Michael ; Keshavan, Matcheri S ; Khadka, Sabin ; Kircher, Tilo ; Kohls, Gregor ; Konrad, Kerstin ; Korucuoglu, Ozlem ; Krämer, Bernd ; Krug, Axel ; Kwon, Jun Soo ; Lambregts-Rommelse, Nanda ; Landén, Mikael ; Lázaro, Luisa ; Lebedeva, Irina ; Lenroot, Rhoshel ; Lesch, Klaus-Peter J. ; Li, Qinqin ; Lim, Kelvin O. ; Liu, Jia ; Lochner, Christine ; London, Edythe D. ; Lonning, Vera ; Lorenzetti, Valentina ; Luciano, Michelle ; Luijten, Maartje ; Lundervold, Astri J. ; Mackey, Scott ; MacMaster, Frank P. ; Maingault, Sophie ; Malpas, Charles B. ; Malt, Ulrik F. ; Mataix-Cols, David ; Martin-Santos, Rocio ; Mayer, Andrew R. ; McCarthy, Hazel ; Mitchell, Philip B. ; Mueller, Bryon A. ; Maniega, Susana Munoz ; Mazoyer, Bernard ; McDonald, Colm ; McLellan, Quinn ; McMahon, Katie L. ; McPhilemy, Genevieve ; Momenan, Reza ; Morales, Angelica M. ; Narayanaswamy, Janardhanan C. ; Moreira, José Carlos Vasques ; Nerland, Stener ; Nestor, Liam ; Nigg, Joel T. ; Nordvik, Jan-Egil ; Novotny, Stephanie ; Oberwelland, Eileen ; O’Gorman, Ruth L. ; Oosterlaan, Jaap ; Oranje, Bob ; Orr, Catherine ; Overs, Bronwyn ; Pauli, Paul ; Paulus, Martin ; Plessen, Kerstin ; Polier, Georg von ; Pomarol-Clotet, Edith ; Qiu, Jiang ; Radua, Joaquim ; Ramos-Quiroga, J. Antoni ; Reddy, Y.C. Janardhan ; Reif, Andreas ; Roberts, Gloria ; Rosa, Pedro ; Rubia, Katya ; Sacchet, Matthew D. ; Sachdev, Perminder S. ; Salvador, Raymond ; Schmaal, Lianne ; Schweren, Lisanne ; Seidman, Larry J. ; Seitz, Jochen ; Serpa, Mauricio Henriques ; Shaw, Philip ; Shumskaya, Elena ; Silk, Timothy J. ; Simmons, Alan N. ; Simulionyte, Egle ; Sinha, Rajita ; Sjoerds, Zsuzsika ; Smelror, Runar Elle ; Soliva, Joan Carlos ; Solowij, Nadia ; Sponheim, Scott R. ; Stein, Dan J. ; Stein, Elliot A. ; Stevens, Michael ; Strike, Lachlan T. ; Sudre, Gustavo ; Sui, Jing ; Tamm, Leanne ; Temmingh, Hendrik S. ; Thoma, Robert J. ; Tomyshev, Alexander S. ; Tronchin, Giulia ; Turner, Jessica A. ; Uhlmann, Anne ; van Erp, Theo G.M. ; van den Heuvel, Odile ; Meer, Dennis van der ; Eijk, Liza van ; Vance, Alasdair ; Veer, Ilya M. ; Veltman, Dick J. ; Venkatasubramanian, Ganesan ; Vilarroya, Oscar ; Vives-Gilabert, Yolanda ; Voineskos, Aristotle N. ; Völzke, Henry ; Vuletic, Daniella ; Walitza, Susanne ; Walter, Henrik ; Walton, Esther ; Wardlaw, Joanna M. ; Wen, Wei ; Westlye, Lars T. ; Whelan, Christopher D. ; White, Tonya ; Wiers, Reinout W. ; Wright, Margaret J. ; Wittfeld, Katharina ; Yang, Tony T. ; Yasuda, Clarissa L. ; Yoncheva, Yuliya ; Yucel, Murat ; Yun, Je-Yeon ; Zanetti, Marcus Vinicius ; Zhen, Zonglei ; Zhu, Xing-xing ; Ziegler, Georg Christoph ; Zierhut, Kathrin ; De Zubicaray, Greig ; Zwiers, Marcel P. ; Glahn, David C. ; Franke, Barbara ; Crivello, Fabrice ; Tzourio-Mazoyer, Nathalie ; Fisher, Simon E. ; Thompson, Paul M. ; Francks, Clyde ; Farde, Lars ; Engberg, Goran ; Erhardt, Sophie ; Cervenka, Simon ; Schwieler, Lilly ; Piehl, Fredrik ; Collste, Karin ; Victorsson, Pauliina ; Malmqvist, Anna ; Hedberg, Mikael ; Orhan, Funda