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Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Ajitanand, N.N. ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bhattarai, P. ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Bouchet, Jonathan ; Brandenburg, James D. ; Brandin, Andrei V. ; Brown, D. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Campbell, J.M. ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chang, Z. ; Chankova-Bunzarova, N. ; Chatterjee, A. ; Chattopadhyay, S. ; Chen, J.H. ; Chen, X. ; Chen, X. ; Cheng, J. ; Cherney, Michael Gerard ; Christie, William ; Contin, Giacomo ; Crawford, Henry J. ; Dedovič, Tatiana G. ; Deng, J. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, X. ; Drachenberg, James Lucus ; Draper, James E. ; Dunlop, James C. ; Efimov, Leonid G. ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Federicova, P. ; Fedorišin, Jan ; Feng, Z. ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Flores, C.E. ; Fujita, J. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Geurts, Frank ; Gibson, Adam ; Girard, M. ; Grosnick, David P. ; Gunarathne, D.S. ; Guo, Y. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harlenderova, Alena ; Harris, John W. ; He, L. ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Hirsch, Andrew S. ; Horvat, S. ; Huang, X. ; Huang, Huan Zhong ; Huang, T. ; Huang, Bingchu ; Humanic, Thomas J. ; Huo, P. ; Igo, George J. ; Jacobs, William W. ; Jentsch, Alexander ; Jia, Jiangyong ; Jiang, K. ; Jowzaee, S. ; Judd, Eleanor G. ; Kabana, Sonia ; Kalinkin, Dmitry ; Kang, K. ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Khan, Z. ; Kikoła, Daniel P. ; Kim, C. ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kočenda, L. M. ; Kocmanek, M. ; Kollegger, Thorsten ; Kosarzewski, Leszek Krzysztof ; Kraishan, A.F. ; Krauth, L. ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga, Nalinda ; Kumar, Lokesh ; Kvapil, Jakub ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Landry, K.D. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, J.H. ; Li, W. ; Li, C. ; Li, Xiaomei ; Li, Y. ; Lidrych, J. ; Lin, T. ; Lisa, Michael A. ; Liu, Y. ; Liu, H. ; Liu, F. ; Liu, P. ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, X. ; Luo, S. ; Ma, L. ; Ma, Yu-Gang ; Ma, G.L. ; Ma, R. ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Mayes, D. ; Meehan, Kathryn ; Mei, Jincheng ; Miller, Z.W. ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mizuno, S. ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Morozov, Dmitry A. ; Mustafa, M.K. ; Nasim, Md. ; Nayak, Tapan Kumar ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Nurušev, Sandibek B. ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Okorokov, Vitaly A. ; Olvitt, D. ; Page, Brian S. ; Pak, Robert ; Pandit, Y. ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pei, Hua ; Perkins, Chris ; Pluta, Jan Marian ; Poniatowska, K. ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Rehbein, M.J. ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Roth, J.D. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Saur, M. ; Schambach, Joachim ; Schmah, Alexander ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, N. ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, M. ; Shen, W.Q. ; Shi, Shusu ; Shi, Z. ; Shou, Q.Y. ; Sichtermann, Ernst P. ; Sikora, Rafał ; Šimko, Miroslav ; Singha, Subhash ; Skoby, Michael J. ; Smirnov, Nikolai ; Smirnov, Dmitri V. ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, X. ; Sun, X.M. ; Sun, Y. ; Surrow, Bernd ; Svirida, Dmitry N. ; Tang, Zebo ; Tang, Aihong ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Tawfik, Abdel Nasser ; Thäder, Jochen ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Trzeciak, Barbara Antonina ; Tsai, Oleg D. ; Tu, B. ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Nieuwenhuizen, Gerrit J. van ; Vasiliev, Alexander Nikolaevich ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Vossen, A. ; Wang, G. ; Wang, Y. ; Wang, Y. ; Wang, F. ; Webb, Grant ; Webb, Jason C. ; Wen, L. ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Y. ; Xiao, Z.G. ; Xie, Guannan ; Xie, W. ; Xu, N. ; Xu, Y.F. ; Xu, Qinghua ; Xu, Z. ; Yang, Y. ; Yang, C. ; Yang, S. ; Yang, Q. ; Ye, Z. ; Ye, Z. ; Yi, L. ; Yip, K. ; Yoo, In-Kwon ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, J.B. ; Zhang, J. ; Zhang, S. ; Zhang, J. ; Zhang, S. ; Zhang, Zuman ; Zhang, Y. ; Zhang, L. ; Zhang, X.P. ; Zhao, J. ; Zhong, C. ; Zhou, C. ; Zhou, L. ; Zhu, X. ; Zhu, Z. ; Zyzak, Maksym
The transversity distribution, which describes transversely polarized quarks in transversely polarized nucleons, is a fundamental component of the spin structure of the nucleon, and is only loosely constrained by global fits to existing semi-inclusive deep inelastic scattering (SIDIS) data. In transversely polarized p↑+p collisions it can be accessed using transverse polarization dependent fragmentation functions which give rise to azimuthal correlations between the polarization of the struck parton and the final state scalar mesons.This letter reports on spin dependent di-hadron correlations measured by the STAR experiment. The new dataset corresponds to 25 pb−1 integrated luminosity of p↑+p collisions at s=500 GeV, an increase of more than a factor of ten compared to our previous measurement at s=200 GeV. Non-zero asymmetries sensitive to transversity are observed at a Q2 of several hundred GeV and are found to be consistent with the former measurement and a model calculation. We expect that these data will enable an extraction of transversity with comparable precision to current SIDIS datasets but at much higher momentum transfers where subleading effects are suppressed.
Unique features of a global human ectoparasite identified through sequencing of the bed bug genome
(2016)
Benoit, Joshua B. ; Adelman, Zach N. ; Reinhardt, Klaus ; Dolan, Amanda ; Poelchau, Monica ; Jennings, Emily C. ; Szuter, Elise M. ; Hagan, Richard W. ; Gujar, Hemant ; Shukla, Jayendra Nath ; Zhu, Fang ; Mohan, Muthugounder ; Nelson, David R. ; Rosendale, Andrew J. ; Derst, Christian ; Resnik, Valentina ; Wernig, Sebastian ; Menegazzi, Pamela ; Wegener, Christian ; Peschel, Nicolai ; Hendershot, Jacob M. ; Blenau, Wolfgang ; Predel, Reinhard ; Johnston, Paul R. ; Ioannidis, Panagiotis ; Waterhouse, Robert M. ; Nauen, Ralf ; Schorn, Corinna ; Ott, Mark-Christoph ; Maiwald, Frank ; Johnston, J. Spencer ; Gondhalekar, Ameya D. ; Scharf, Michael E. ; Peterson, Brittany F. ; Raje, Kapil R. ; Hottel, Benjamin A. ; Armisén, David ; Crumière, Antonin Jean Johan ; Refki, Peter Nagui ; Santos, Maria Emilia ; Sghaier, Essia ; Viala, Séverine ; Khila, Abderrahman ; Ahn, Seung-Joon ; Childers, Christopher ; Lee, Chien-Yueh ; Lin, Han ; Hughes, Daniel S. T. ; Duncan, Elizabeth J. ; Murali, Shwetha C. ; Qu, Jiaxin ; Dugan, Shannon ; Lee, Sandra L. ; Chao, Hsu ; Dinh, Huyen ; Han, Yi ; Doddapaneni, Harshavardhan ; Worley, Kim C. ; Muzny, Donna Marie ; Wheeler, David ; Panfilio, Kristen A. ; Vargas Jentzsch, Iris M. ; Vargo, Edward L. ; Booth, Warren ; Friedrich, Markus ; Weirauch, Matthew T. ; Anderson, Michelle A. ; Jones, Jeffery W. ; Mittapalli, Omprakash ; Zhao, Chaoyang ; Zhou, Jing-Jiang ; Evans, Jay D. ; Attardo, Geoffrey M. ; Robertson, Hugh M. ; Zdobnov, Evgeny M. ; Ribeiro, José M. C. ; Gibbs, Richard A. ; Werren, John H. ; Palli, Subba Reddy ; Schal, Coby ; Richards, Stephen
The bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650 Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasite.
Bauer, Michael ; Glenn, Tasha ; Achtyes, Eric D. ; Agaoglu, Esen ; Altınbaş, Kürşat ; Andreassen, Ole A. ; Angelopoulos, Elias ; Ardau, Raffaella ; Arrua Vares, Edgar ; Aydin, Memduha ; Ayhan, Yavuz ; Baethge, Christopher Jan ; Bauer, Rita ; Baune, Bernhard T. ; Balaban, Ceylan ; Becerra-Palars, Claudia ; Behere, Aniruddh P. ; Behere, Prakash B. ; Belete, Habte ; Belete, Tilahun ; Belizario, Gabriel Okawa ; Bellivier, Frank ; Belmaker, Robert H. ; Benedetti, Francesco ; Berk, Michael ; Bersudsky, Yuly ; Bicakci, Şule ; Birabwa-Oketcho, Harriet ; Bjella, Thomas D. ; Brady, Conan ; Cabrera, Jorge ; Cappucciati, Marco ; Castro, Angela Marianne Paredes ; Chen, Wei-Ling ; Cheung, Eric Y. Wo ; Chiesa, Silvia ; Crowe, Marie ; Cuomo, Alessandro ; Dallaspezia, Sara ; Del Zompo, Maria ; Desai, Pratikkumar ; Dodd, Seetal ; Donix, Markus ; Etain, Bruno ; Fagiolini, Andrea ; Fellendorf, Frederike Tabea ; Ferensztajn-Rochowiak, Ewa ; Fiedorowicz, Jess G. ; Fountoulakis, Kostas N. ; Frye, Mark A. ; Geoffroy, Pierre A. ; Gonzalez-Pinto, Ana ; Gottlieb, John F. ; Grof, Paul ; Haarman, Bartholomeus C. M. ; Harima, Hirohiko ; Hasse-Sousa, Mathias ; Henry, Chantal ; Høffding, Lone ; Houenou, Josselin ; Imbesi, Massimiliano ; Isometsä, Erkki T. ; Ivkovic, Maja ; Janno, Sven ; Johnsen, Simon ; Kapczinski, Flávio ; Karakatsoulis, Gregory N. ; Kardell, Mathias ; Kessing, Lars Vedel ; Kim, Seong Jae ; König, Barbara ; Kot, Timur L. ; Koval, Michael ; Kunz, Mauricio ; Lafer, Beny ; Landén, Mikael ; Larsen, Erik R. ; Lenger, Melanie ; Lewitzka, Ute ; Licht, Rasmus W. ; Lopez-Jaramillo, Carlos ; MacKenzie, Alan ; Madsen, Helle Østergaard ; Madsen, Simone Alberte Kongstad A. ; Mahadevan, Jayant ; Mahardika, Agustine ; Manchia, Mirko ; Marsh, Wendy ; Martinez-Cengotitabengoa, Monica ; Martiny, Klaus ; Mashima, Yuki ; McLoughlin, Declan M. ; Meesters, Ybe ; Melle, Ingrid ; Meza-Urzúa, Fátima ; Ming, Mok Yee ; Monteith, Scott ; Moorthy, Muthukumaran ; Morken, Gunnar ; Mosca, Enrica ; Mozzhegorov, Anton A. ; Munoz, Rodrigo ; Mythri, Starlin V. ; Nacef, Fethi ; Nadella, Ravi K. ; Nakanotani, Takako ; Nielsen, René Ernst ; O'Donovan, Claire ; Omrani, Adel ; Osher, Yamima ; Ouali, Uta ; Pantovic-Stefanovic, Maja ; Pariwatcharakul, Pornjira ; Petite, Joanne ; Pfennig, Andrea ; Pica Ruiz, Yolanda ; Pilhatsch, Maximilian ; Pinna, Marco ; Pompili, Maurizio ; Porter, Richard ; Quiroz, Danilo ; Rabelo-da-Ponte, Francisco Diego ; Ramesar, Raj ; Rasgon, Natalie ; Ratta-apha, Woraphat ; Ratzenhofer, Michaela ; Redahan, Maria ; Reddy, M. S. ; Reif, Andreas ; Reininghaus, Eva Z. ; Richards, Jenny Gringer ; Ritter, Philipp ; Rybakowski, Janusz K. ; Sathyaputri, Leela ; Scippa, Ângela M. ; Simhandl, Christian ; Severus, Emanuel ; Smith, Daniel ; Smith, José ; Stackhouse Jr., Paul W. ; Stein, Dan J. ; Stilwell, Kellen ; Strejilevich, Sergio ; Su, Kuan-Pin ; Subramaniam, Mythily ; Sulaiman, Ahmad Hatim ; Suominen, Kirsi ; Tanra, Andi J. ; Tatebayashi, Yoshitaka ; Teh, Wen Lin ; Tondo, Leonardo ; Torrent, Carla ; Tuinstra, Daniel ; Uchida, Takahito ; Vaaler, Arne E. ; Veeh, Julia ; Vieta, Eduard ; Viswanath, Biju ; Yoldi-Negrete, Maria ; Yalcinkaya, Oguz Kaan ; Young, Allan H. ; Zgueb, Yosra ; Whybrow, Peter C.
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm this finding using international data from 42% more collection sites and 25% more countries. Methods: Data analyzed were from 71 prior and new collection sites in 40 countries at a wide range of latitudes. The analysis included 4876 patients with bipolar I disorder, 45% more data than previously analyzed. Of the patients, 1496 (30.7%) had a history of suicide attempt. Solar insolation data, the amount of the sun’s electromagnetic energy striking the surface of the earth, was obtained for each onset location (479 locations in 64 countries). Results: This analysis confirmed the results of the exploratory study with the same best model and slightly better statistical significance. There was a significant inverse association between a history of suicide attempts and the ratio of mean winter insolation to mean summer insolation (mean winter insolation/mean summer insolation). This ratio is largest near the equator which has little change in solar insolation over the year, and smallest near the poles where the winter insolation is very small compared to the summer insolation. Other variables in the model associated with an increased risk of suicide attempts were a history of alcohol or substance abuse, female gender, and younger birth cohort. The winter/summer insolation ratio was also replaced with the ratio of minimum mean monthly insolation to the maximum mean monthly insolation to accommodate insolation patterns in the tropics, and nearly identical results were found. All estimated coefficients were significant at p < 0.01. Conclusion: A large change in solar insolation, both between winter and summer and between the minimum and maximum monthly values, may increase the risk of suicide attempts in bipolar I disorder. With frequent circadian rhythm dysfunction and suicidal behavior in bipolar disorder, greater understanding of the optimal roles of daylight and electric lighting in circadian entrainment is needed.
Coccolini, Federico ; Roberts, Derek ; Ansaloni, Luca ; Ivatury, Rao ; Gamberini, Emiliano ; Kluger, Yoram ; Moore, Ernest E. ; Coimbra, Raul ; Kirkpatrick, Andrew Wallace ; Pereira, Bruno M. ; Montori, Giulia ; Ceresoli, Marco ; Abu-Zidan, Fikri M. ; Sartelli, Massimo ; Velmahos, George C. ; Fraga, Gustavo Pereira ; Leppaniemi, Ari ; Tolonen, Matti ; Galante, Joseph ; Razek, Tarek ; Maier, Ron ; Bala, Miklosh ; Sakakushev, Boris ; Khokha, Vladimir ; Malbrain, Manu ; Agnoletti, Vanni ; Peitzman, Andrew B. ; Demetrashvili, Zaza ; Sugrue, Michael ; Di Saverio, Salomone ; Martzi, Ingo ; Soreide, Kjetil ; Biffl, Walter ; Ferrada, Paula ; Parry, Neil ; Montravers, Philippe ; Melotti, Rita Maria ; Salvetti, Francesco ; Valetti, Tino M. ; Scalea, Thomas ; Chiara, Osvaldo ; Cimbanassi, Stefania ; Kashuk, Jeffry L. ; Larrea, Martha ; Martinez Hernandez, Juan Alberto ; Lin, Heng-Fu ; Chirica, Mircea ; Arvieux, Catherine ; Bing, Camilla ; Horer, Tal ; Simone, Belinda De ; Masiakos, Peter T. ; Reva, Viktor ; De Angelis, Nicola ; Kike, Kaoru ; Balogh, Zsolt J. ; Fugazzola, Paola ; Tomasoni, Matteo ; Latifi, Rifat ; Naidoo, Noel ; Weber, Dieter ; Handolin, Lauri ; Inaba, Kenji ; Hecker, Andreas ; Yuan, Kuo-Ching ; Ordoñez, Carlos A. ; Rizoli, Sandro ; Gomes, Carlos Augusto ; De Moya, Marc ; Wani, Imtiaz ; Mefire, Alain Chichom ; Boffard, Ken ; Napolitano, Lena ; Catena, Fausto
Damage control resuscitation may lead to postoperative intra-abdominal hypertension or abdominal compartment syndrome. These conditions may result in a vicious, self-perpetuating cycle leading to severe physiologic derangements and multiorgan failure unless interrupted by abdominal (surgical or other) decompression. Further, in some clinical situations, the abdomen cannot be closed due to the visceral edema, the inability to control the compelling source of infection or the necessity to re-explore (as a “planned second-look” laparotomy) or complete previously initiated damage control procedures or in cases of abdominal wall disruption. The open abdomen in trauma and non-trauma patients has been proposed to be effective in preventing or treating deranged physiology in patients with severe injuries or critical illness when no other perceived options exist. Its use, however, remains controversial as it is resource consuming and represents a non-anatomic situation with the potential for severe adverse effects. Its use, therefore, should only be considered in patients who would most benefit from it. Abdominal fascia-to-fascia closure should be done as soon as the patient can physiologically tolerate it. All precautions to minimize complications should be implemented.
Frantz, Laurent A. F. ; Haile, James ; Lin, Audrey T. ; Scheu, Amelie ; Geörg, Christina ; Benecke, Norbert ; Alexander, Michelle ; Linderholm, Anna ; Mullin, Victoria E. ; Daly, Kevin G. ; Battista, Vincent M. ; Price, Max ; Gron, Kurt J. ; Alexandri, Panoraia ; Arbogast, Rose-Marie ; Arbuckle, Benjamin ; Bălăşescu, Adrian ; Barnett, Ross ; Bartosiewicz, László ; Baryshnikov, Gennady ; Bonsall, Clive ; Borić, Dušan ; Boroneanţ, Adina ; Bulatović, Jelena ; Çakırlar, Canan ; Carretero, José-Miguel ; Chapman, John ; Church, Mike ; Crooijmans, Richard ; DeCupere, Bea ; Detry, Cleia ; Dimitrijević, Vesna ; Dumitraşcu, Valentin ; Du Plessis, Louis ; Edwards, Ceiridwen ; Erek, Cevdet Merih ; Erim Özdoğan, Aslı ; Ervynck, Anton ; Fulgione, Domenico ; Gligor, Mihai ; Götherström, Anders ; Gourichon, Lionel ; Groenen, Martien A. M. ; Helmer, Daniel ; Hongo, Hitomi ; Horwitz, Liora Kolska ; Irving-Pease, Evan K. ; Lebrasseur, Ophélie ; Lesur, Joséphine ; Malone, Caroline ; Manaserya, Ninna ; Marciniak, Arkadiusz ; Martlew, Holley ; Mashkour, Marjan ; Matthews, Roger ; Motuzaitė Matuzevičiūtė, Giedrė ; Maziar, Sepideh ; Meijaard, Erik ; McGovern, Tom ; Megens, Hendrik-Jan ; Miller, Rebecca ; Mohaseb, Azadeh Fatemeh ; Orschiedt, Jörg ; Orton, David ; Papathanasiou, Anastasia ; Parker Pearson, Michael ; Pinhasi, Ron ; Radmanović, Darko ; Ricaut, François-Xavier ; Richards, Mike ; Sabin, Richard ; Sarti, Lucia ; Schier, Wolfram ; Sheikhi, Shiva ; Stephan, Elisabeth ; Stewart, John R. ; Stoddart, Simon ; Tagliacozzo, Antonio ; Tasić, Nenad N. ; Trantalidou, Katerina ; Tresset, Anne ; Valdiosera, Cristina ; Hurk, Youri van den ; Poucke, Sophie van ; Vigne, Jean-Denis ; Yanevich, Alexander ; Zeeb-Lanz, Andrea ; Triantafyllidis, Alexandros ; Gilbert, M. Thomas P. ; Schibler, Jörg ; Rowley-Conwy, Peter ; Zeder, Melinda ; Peters, Joris ; Cucchi, Thomas ; Bradley, Daniel G. ; Dobney, Keith ; Burger, Joachim ; Evin, Allowen ; Girdland-Flink, Linus ; Larson, Greger
Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic mtDNA signature disappeared and was replaced by haplotypes associated with European wild boars. This turnover could be accounted for by substantial gene flow from local European wild boars, although it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hypotheses, we obtained mtDNA sequences from 2,099 modern and ancient pig samples and 63 nuclear ancient genomes from Near Eastern and European pigs. Our analyses revealed that European domestic pigs dating from 7,100 to 6,000 y BP possessed both Near Eastern and European nuclear ancestry, while later pigs possessed no more than 4% Near Eastern ancestry, indicating that gene flow from European wild boars resulted in a near-complete disappearance of Near East ancestry. In addition, we demonstrate that a variant at a locus encoding black coat color likely originated in the Near East and persisted in European pigs. Altogether, our results indicate that while pigs were not independently domesticated in Europe, the vast majority of human-mediated selection over the past 5,000 y focused on the genomic fraction derived from the European wild boars, and not on the fraction that was selected by early Neolithic farmers over the first 2,500 y of the domestication process.
Hansen, Anne-Louise Smidt ; Buchan, Gregory J. ; Rühl, Michael ; Mukai, Kojiro ; Salvatore, Sonia R. ; Ogawa, Emari ; Andersen, Sidsel ; Iversen, Marie B. ; Thielke, Anne L. ; Gunderstofte, Camilla ; Motwani, Mona ; Møller, Charlotte T. ; Jakobsen, Andreas S. ; Fitzgerald, Katherine A. ; Roos, Jessica ; Lin, Rongtuan ; Maier, Thorsten Jürgen ; Goldbach-Mansky, Raphaela ; Miner, Cathrine A. ; Qian, Wei ; Miner, Jonathan ; Rigby, Rachel ; Rehwinkel, Jan ; Jakobsen, Martin R. ; Arai, Hiroyuki ; Taguchi, Tomohiko ; Schopfer, Francisco J. ; Olagnier, David ; Holm, Christian K.
The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies, including systemic lupus erythematosus (SLE), Aicardi–Goutières syndrome (AGS), and stimulator of IFN genes-associated vasculopathy with onset in infancy (SAVI). The involvement of STING in these diseases points to an unmet need for the development of agents that inhibit STING signaling. Here, we report that endogenously formed nitro-fatty acids can covalently modify STING by nitro-alkylation. These nitro-alkylations inhibit STING palmitoylation, STING signaling, and subsequently, the release of type I IFN in both human and murine cells. Furthermore, treatment with nitro-fatty acids was sufficient to inhibit production of type I IFN in fibroblasts derived from SAVI patients with a gain-of-function mutation in STING. In conclusion, we have identified nitro-fatty acids as endogenously formed inhibitors of STING signaling and propose for these lipids to be considered in the treatment of STING-dependent inflammatory diseases.
Moustakim, Moses ; Clark, Peter G. K. ; Trulli, Laura ; Fuentes de Arriba, Angel L. ; Ehebauer, Matthias T. ; Chaikuad, Apirat ; Murphy, Emma J. ; Mendez-Johnson, Jacqui ; Daniels, Danette ; Hou, Chun-Feng D. ; Lin, Yu-Hui ; Walker, John R. ; Hui, Raymond ; Yang, Hongbing ; Dorrell, Lucy ; Rogers, Catherine M. ; Monteiro, Octovia ; Fedorov, Oleg ; Huber, Kilian ; Knapp, Stefan ; Heer, Jag ; Dixon, Darren ; Brennan, Paul E.
The p300/CBP‐associated factor (PCAF) and related GCN5 bromodomain‐containing lysine acetyl transferases are members of subfamily I of the bromodomain phylogenetic tree. Iterative cycles of rational inhibitor design and biophysical characterization led to the discovery of the triazolopthalazine‐based L‐45 (dubbed L‐Moses) as the first potent, selective, and cell‐active PCAF bromodomain (Brd) inhibitor. Synthesis from readily available (1R,2S)‐(−)‐norephedrine furnished L‐45 in enantiopure form. L‐45 was shown to disrupt PCAF‐Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co‐crystal structure of L‐45 with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. Compound L‐45 shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell‐permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, Brian ; Chang, Feng-Han ; Chang, Zilong ; Chankova-Bunzarova, Nedialka ; Chatterjee, Arghya ; Chattopadhyay, Subhasis ; Chen, Jinhui ; Chen, Xiaolong ; Cheng, Jianping ; Cherney, Michael Gerard ; Christie, William ; Crawford, Henry J. ; Csanád, Máté ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, Xin ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harris, John W. ; He, Liang ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Holub, Lukáš ; Hong, Yifan ; Horvat, Stephen P. ; Huang, Bingchu ; Huang, Huan Zhong ; Huang, Shengli ; Huang, Te-Chuan ; Huang, Xinjie ; Humanic, Thomas J. ; Huo, Peng ; Igo, George J. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, Kun ; Jowzaee, Sedigheh ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, Kejun ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, Chong ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, Jeong-Hun ; Li, Cheng ; Li, Wei ; Li, Wei ; Li, Xin ; Li, Yuanjing ; Liang, Yue ; Licenik, Robert ; Lin, Ting ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, Feng ; Liu, Huanzhao ; Liu, Peifeng ; Liu, Peng ; Liu, Tong ; Liu, Xiaoyu ; Liu, Y. ; Liu, Zhen ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, Siwei ; Luo, Xiaofeng ; Ma, Guo-Liang ; Ma, Long ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nasim, Md. ; Nayak, Kishora ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, Neha ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, Ming ; Shen, Fuwang ; Shen, Wenqing ; Shi, Shusu ; Shou, Qiye ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, Xiangming ; Sun, Yongjie ; Sun, Yuliang ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Biao ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, Fuqiang ; Wang, Gang ; Wang, Pengfei ; Wang, Yi ; Wang, Yaping ; Webb, Jason C. ; Wen, Liwen ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Yang ; Xiao, Zhigang ; Xie, Guannan ; Xie, Wei ; Xu, Haojie ; Xu, Nu ; Xu, Qinghua ; Xu, Yi-Fei ; Xu, Zhangbu ; Yang, Chi ; Yang, Qian ; Yang, Shuai ; Yang, Yi ; Yang, Zhenzhen ; Ye, Zaochen ; Ye, Zhenyu ; Yi, Li ; Yip, Kin ; Yoo, In-Kwon ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Dingwei ; Zhang, Liang ; Zhang, Shenghui ; Zhang, Song ; Zhang, Xiaoping ; Zhang, Yifei ; Zhang, Zhengqiao ; Zhao, Jie ; Zhong, Chen ; Zhou, Chensheng ; Zhu, Xianglei ; Zhu, Zhanwen ; Zurek, Marian ; Zyzak, Maksym
J/ψ suppression has long been considered a sensitive signature of the formation of the Quark-Gluon Plasma (QGP) in relativistic heavy-ion collisions. In this letter, we present the first measurement of inclusive J/ψ production at mid-rapidity through the dimuon decay channel in Au+Au collisions at √sNN = 200 GeV with the STAR experiment. These measurements became possible after the installation of the Muon Telescope Detector was completed in 2014. The J/ψ yields are measured in a wide transverse momentum (pT) range of 0.15 GeV/c to 12 GeV/c from central to peripheral collisions. They extend the kinematic reach of previous measurements at RHIC with improved precision. In the 0-10% most central collisions, the J/ψ yield is suppressed by a factor of approximately 3 for pT > 5 GeV/c relative to that in p + p collisions scaled by the number of binary nucleon-nucleon collisions. The J/ψ nuclear modification factor displays little dependence on pT in all centrality bins. Model calculations can qualitatively describe the data, providing further evidence for the color-screening effect experienced by J/ψ mesons in the QGP.