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(2008)
Gregor, Thomas ; Kulbrock, Peter ; Parolly, Gerald ; Foerster, Ekkehard ; Weber, Heinrich E. ; Matzke-Hajek, Günter ; Hand, Ralf
Bönsel, Dirk ; Jong, Martin de ; Dyballa, Peter ; Ehmke, Wolfgang ; Emrich, Peter ; Feller, Benjamin ; Göbel, Brunhilde ; Gregor, Thomas ; Hodvina, Sylvain ; Kasperek, Gerwin ; Korte, Egbert ; Egbert, Ute ; Meyer, Stefan ; Nesemann, Hasko Friedrich ; Raabe, Uwe ; Sauerwein, Bernd ; Schmidt, Marco ; Schröder, Christof Nikolaus ; Schwab, Antje ; Stoodt, Rainer ; Uebeler, Michael
Die Fundmeldungen in Band 33 von Botanik und Naturschutz in Hessen stammen von: Dirk Bönsel, Martin de Jong, Wolfgang Ehmke, Peter Emrich, Benjamin Feller, Brunhilde Göbel, Thomas Gregor, Arthur Händler, Sylvain Hodvina, Gerwin Kasperek, Egbert Korte, Ute Lange, Stefan Meyer, Hasko Friedrich Nesemann, Uwe Raabe, Bernd Sauerwein, Marco Schmidt, Christof Nikolaus Schröder, Antje Schwab, Rainer Stoodt und Michael Uebeler.
Angegeben wird jeweils das Sammeldatum des für die Chromosomenzählung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie –
getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze. Wird nur ein Datum angegeben, ist allein die Wildaufsammlung dokumentiert. Die Abkürzungen der Herbarien richten sich nach Holmgren & al. (1990, sowie Onlinenachträge, für die neuerdings B. Thiers verantwortlich zeichnet). Taxonomie und Nomenklatur richten sich nach der aktuellen deutschen Standardliste (BUTTLER & HAND 2008). Die Abbildungen zeigen Metaphasen, die an Quetschpräparaten von Wurzelspitzen gewonnen wurden (zur Methodik siehe VOGT & APARICIO 2000). Ralf Hand dankt Michael Meyer und seinem Gärtnerteam sowie Monika Lüchow und Monika Cubr (alle Botanischer Garten und Botanisches Museum Berlin-Dahlem) für Kultur, Dokumentation und Hilfe bei der Zählung von Material.
Angegeben wird jeweils das Sammeldatum des für die Chromosomenzählung verwendeten Materials (Lebendpflanze, Samen) zuzüglich eines eventuell gesammelten Beleges sowie – getrennt durch einen Schrägstrich – Sammeldatum und Aufbewahrungsort eines Beleges der gezählten Pflanze. Wird nur ein Datum angegeben, ist allein die Wildaufsammlung dokumentiert. Die Abkürzungen der Herbarien richten sich nach Holmgren & al. (1990, sowie Online-Nachträge, für die neuerdings B. Thiers verantwortlich zeichnet). Taxonomie und Nomenklatur richten sich nach der aktuellen deutschen Standardliste (Buttler & Hand 2008) und den in dieser Zeitschrift publizierten Nachträgen. Die Abbildungen zeigen Metaphasen, die an Quetschpräparaten von Wurzelspitzen gewonnen wurden (zur Methodik siehe Vogt & Aparicio 2000). Ralf Hand dankt Michael Meyer und seinem Gärtnerteam sowie Monika Lüchow und Marion Cubr (alle Botanischer Garten und Botanisches Museum Berlin-Dahlem) für Kultur, Dokumentation und Hilfe bei der Zählung von Material.
Liu, Xingfeng ; Huai, Jisen ; Endle, Heiko ; Schlüter, Leslie ; Fan, Wei ; Li, Yunbo ; Richers, Sebastian ; Yurugi, Hajime ; Rajalingam, Krishnaraj ; Ji, Haichao ; Cheng, Hong ; Rister, Benjamin ; Horta, Guilherme ; Baumgart, Jan ; Berger, Hendrik ; Laube, Gregor ; Schmitt, Ulrich ; Schmeißer, Michael Joachim ; Böckers, Tobias M. ; Tenzer, Stefan ; Vlachos, Andreas ; Deller, Thomas ; Nitsch, Robert ; Vogt, Johannes
Alterations in dendritic spine numbers are linked to deficits in learning and memory. While we previously revealed that postsynaptic plasticity-related gene 1 (PRG-1) controls lysophosphatidic acid (LPA) signaling at glutamatergic synapses via presynaptic LPA receptors, we now show that PRG-1 also affects spine density and synaptic plasticity in a cell-autonomous fashion via protein phosphatase 2A (PP2A)/β1-integrin activation. PRG-1 deficiency reduces spine numbers and β1-integrin activation, alters long-term potentiation (LTP), and impairs spatial memory. The intracellular PRG-1 C terminus interacts in an LPA-dependent fashion with PP2A, thus modulating its phosphatase activity at the postsynaptic density. This results in recruitment of adhesome components src, paxillin, and talin to lipid rafts and ultimately in activation of β1-integrins. Consistent with these findings, activation of PP2A with FTY720 rescues defects in spine density and LTP of PRG-1-deficient animals. These results disclose a mechanism by which bioactive lipid signaling via PRG-1 could affect synaptic plasticity and memory formation.
Meybohm, Patrick ; Lindau, Simone ; Treskatsch, Sascha ; Francis, Roland ; Spies, Claudia ; Velten, Markus ; Wittmann, Maria ; Güresir, Erdem Özer ; Stoppe, Christian ; Kowark, Ana ; Coburn, Mark ; Selleng, Sixten ; Baschin, Marcel ; Jenichen, Gregor ; Meersch, Melanie ; Ermert, Thomas ; Zarbock, Alexander ; Kranke, Peter ; Kredel, Markus ; Helf, Antonia ; Laufenberg-Feldmann, Rita ; Ferner, Marion ; Wittenmeier, Eva ; Gürtler, Karl-Heinz ; Kienbaum, Peter ; Abreu, Marcelo Gama de ; Sander, Michael ; Bauer, Michael ; Seyfried, Timo ; Grünewald, Matthias Lars ; Choorapoikayil, Suma ; Müller, Markus M. ; Seifried, Erhard ; Brosteanu, Oana ; Bogatsch, Holger ; Hasenclever, Dirk ; Zacharowski, Kai
Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. The purpose of the study is to evaluate whether elderly surgical patients may benefit from a liberal red blood cell (RBC) transfusion strategy compared to a restrictive transfusion strategy.
Methods: The LIBERAL Trial is a prospective, randomized, multicentre, controlled clinical phase IV trial randomising 2470 elderly (≥ 70 years) patients undergoing intermediate- or high-risk non-cardiac surgery. Registered patients will be randomised only if Haemoglobin (Hb) reaches ≤9 g/dl during surgery or within 3 days after surgery either to the LIBERAL group (transfusion of a single RBC unit when Hb ≤ 9 g/dl with a target range for the post-transfusion Hb level of 9–10.5 g/dl) or the RESTRICTIVE group (transfusion of a single RBC unit when Hb ≤ 7.5 g/dl with a target range for the post-transfusion Hb level of 7.5–9 g/dl). The intervention per patient will be followed until hospital discharge or up to 30 days after surgery, whichever occurs first. The primary efficacy outcome is defined as a composite of all-cause mortality, acute myocardial infarction, acute ischaemic stroke, acute kidney injury (stage III), acute mesenteric ischaemia and acute peripheral vascular ischaemia within 90 days after surgery. Infections requiring iv antibiotics with re-hospitalisation are assessed as important secondary endpoint. The primary endpoint will be analysed by logistic regression adjusting for age, cancer surgery (y/n), type of surgery (intermediate- or high-risk), and incorporating centres as random effect.
Discussion: The LIBERAL-Trial will evaluate whether a liberal transfusion strategy reduces the occurrence of major adverse events after non-cardiac surgery in the geriatric population compared to a restrictive strategy within 90 days after surgery.
Trial registration: ClinicalTrials.gov (identifier: NCT03369210).
In 23 survey areas with woodland vegetation or woodland succession in Frankfurt/Main with a total size of 134 hectares, woody species were surveyed (excluding species only occurring as planted individuals). We found 149 woody taxa; 42% of them indigenous, and 58% non-native. Out of the 86 non-native taxa, 49 were naturalized in Frankfurt while 37 were considered as casual. Among non-native taxa, East Asian taxa formed the largest phytogeographic group. We found taxa originating from horticulture (cultigens) to be an important part of the woody flora of Frankfurt/Main. The most common taxa were Acer pseudoplatanus, A. platanoides, Betula pendula, and Sambucus nigra; the two Acer species were regarded as naturalized. Non-native woody species were generally common (with percentages ranging from 24% to 79% in individual areas).
In den Jahren 1987 bis 1990 wurden die im Main-Kinzig-Kreis bekanntgewordenen Kalksümpfe floristisch und vegetationskundlich untersucht. Als charakteristische Pflanzengesellschaften wurden das Cratoneuretum commutati, das Molinietum caeruleae caricetosum hostianae und eine Basalgesellschaft des Caricion davallianae festgestellt und mit Vegetationsaufnahmen belegt. 31 Kalksumpfstandorte werden beschrieben. Für die 21 Flächen, auf denen die typische Vegetation noch erhalten ist, werden Pflegehinweise gegeben. Die hauptsächliche Gefährdungsursache liegt heute in der Aufgabe der landwirtschaftlichen Nutzung.
Es wird über das Vorkommen von acidophilen, schafschwingelreichen Magerrasen in Hessen berichtet. Derartige Magerrasen mit Sand-Grasnelke (Armeria elongata) sind auf die Sandgebiete des Rhein-Main-Tieflandes beschränkt, wo sie oft eine Folgegesellschaft von Silbergras-Rasen darstellen. Acidophile, schafschwingelreiche Magerrasen ohne Sand-Grasnelke scheinen in Hessen auf nährstoffarmen Gesteinen, insbesondere Buntsandstein recht verbreitet zu sein. Dieser bisher wenig beachtete Magerrasentyp ist vor allem an Wegböschungen anzutreffen. Mit 12 Vegetationsaunahmen aus Osthessen wird die Gesellschaft dokumentiert. Die nomenklatorische Situation der für derartige Syntaxa verwandten Assoziationsnamen wird referiert. Lectotypisierungen von Festuco ovinae-Thymetum angustifolii Tüxen 1928 ex Tüxen 1937, Diantho-Festucetum tenuifoliae Knapp 1978, Polytricho-Festucetum tenuifoliae Knapp 1978 und Plantagini-Festucion Passarge 1964 werden vorgenommen. Als korrekter Verbandsname für die acidophilen Sandrasen kann das Armerion elongatae Pötsch 1962 gelten.