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Der UniReport sprach im Institut für Soziologie mit Prof. Thomas Lemke, dem Geschäftsführenden Direktor des Instituts, und den Studierenden Luisa Hecker (Master) und Adam Jendrzejewski (Bachelor) über das Selbstverständnis des Faches, über Studienbedingungen und über die gesellschaftliche Rolle der Soziologie.
Este artigo elucida, em primeiro lugar, os vários significados da noção francesa de dispositif e contrasta-a com os usos de "aparelho" ("appareil"), por um lado, e "reunião" ("agencement"), por outro. A segunda parte apresenta o uso distintivo de Foucault do conceito de dispositivo. O argumento baseia-se na tese de que a noção de dispositivo de Foucault está firmemente ancorada em uma analítica do governo, na medida em que se concentra na direção e regulação de forças agenciais e processos vitais. Na última parte, proponho combinar uma analítica do governo, seguindo Foucault, com insights dos Estudos de Ciência e Tecnologia (STS). Argumento que essa síntese teórica entre STS e uma analítica do governo ajuda a corrigir os problemas de muitas análises da sociologia política e da teoria social e política ao enfrentar as transformações e mudanças nas sociedades contemporâneas.
Pathogenic variants in PRRT2, encoding the proline-rich transmembrane protein 2, have been associated with an evolving spectrum of paroxysmal neurologic disorders. Based on a cohort of children with PRRT2-related infantile epilepsy, this study aimed at delineating the broad clinical spectrum of PRRT2-associated phenotypes in these children and their relatives. Only a few recent larger cohort studies are on record and findings from single reports were not confirmed so far. We collected detailed genetic and phenotypic data of 40 previously unreported patients from 36 families. All patients had benign infantile epilepsy and harbored pathogenic variants in PRRT2 (core cohort). Clinical data of 62 family members were included, comprising a cohort of 102 individuals (extended cohort) with PRRT2-associated neurological disease. Additional phenotypes in the cohort of patients with benign sporadic and familial infantile epilepsy consist of movement disorders with paroxysmal kinesigenic dyskinesia in six patients, infantile-onset movement disorders in 2 of 40 individuals, and episodic ataxia after mild head trauma in one girl with bi-allelic variants in PRRT2. The same girl displayed a focal cortical dysplasia upon brain imaging. Familial hemiplegic migraine and migraine with aura were reported in nine families. A single individual developed epilepsy with continuous spikes and waves during sleep. In addition to known variants, we report the novel variant c.843G>T, p.(Trp281Cys) that co-segregated with benign infantile epilepsy and migraine in one family. Our study highlights the variability of clinical presentations of patients harboring pathogenic PRRT2 variants and expands the associated phenotypic spectrum.