Refine
Year of publication
Document Type
- Article (170)
- Preprint (43)
- Report (2)
- Review (2)
- Conference Proceeding (1)
- Working Paper (1)
Has Fulltext
- yes (219)
Is part of the Bibliography
- no (219)
Keywords
- LHC (8)
- Breast cancer (4)
- breast cancer (4)
- ALICE (3)
- ALICE experiment (3)
- Depression (3)
- Hadron-Hadron Scattering (3)
- SARS-CoV-2 (3)
- pp collisions (3)
- Beauty production (2)
- Bipolar disorder (2)
- COVID-19 (2)
- Diagnostik (2)
- Früherkennung (2)
- Gene expression (2)
- Genetics (2)
- HNSCC (2)
- Heavy Ions (2)
- Heavy-ion collisions (2)
- Mammakarzinom (2)
- Nachsorge (2)
- Richtlinie (2)
- Single electrons (2)
- Surgery (2)
- diagnosis (2)
- follow‑up (2)
- guideline (2)
- screening (2)
- 18-Hydroxycorticosteron (1)
- 18-OH corticosterone (1)
- 900 GeV (1)
- AChE (1)
- ALICE LHC (1)
- APP (1)
- Active middle ear implants (1)
- Adherencia terapéutica (1)
- Afghanistan (1)
- Allogeneic hematopoietic stem cell transplantation (1)
- Alzheimer (1)
- Amizon (1)
- Amyloid precursor protein (1)
- Anandamide (1)
- Animal models (1)
- Anti-seizure medication (1)
- Antirheumatic agents (1)
- Arteria ophthalmica (1)
- Artificial Intelligence (1)
- Atoms (1)
- Auditory system (1)
- Azacitidine (1)
- Balance function (1)
- Behavior (1)
- Biodiversity Data (1)
- Biomonitoring (1)
- Blindness (1)
- Bone conduction devices (1)
- Bone metastases (1)
- Botanical Collections (1)
- Business strategy in drug development (1)
- C3M (1)
- C4M (1)
- CA1 (1)
- CCL2 (1)
- CRISPR/Cas (1)
- CVID (1)
- Calorimeters (1)
- Cell membranes (1)
- Charge correlations (1)
- Charged-particle density (1)
- Charm physics (1)
- Chemical dispersant (1)
- Child (1)
- Child abuse (1)
- Childhood abuse (1)
- Clinical Trials and Observations (1)
- Clinical genetics (1)
- Clinical variation (1)
- Cognitive impairment (1)
- Compact astrophysical objects (1)
- Comparative effectiveness research (1)
- Comparison with QCD (1)
- Complex posttraumatic stress disorder (1)
- Compression stocking (1)
- Consensus (1)
- Consensus statement (1)
- Conservation (1)
- Conservation biogeography (1)
- DBT (1)
- DBT-PTS (1)
- DBT-PTSD (1)
- DBTTSD (1)
- DLI (1)
- Dataset bias (1)
- Ddialectic behavioural therapy (1)
- Decitabine (1)
- Deep vein thrombosis (1)
- Dermatomyositis (1)
- Diagnosis (1)
- Diagnostic markers (1)
- Dialectical behavioural therapy (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital mammography (1)
- Digitization (1)
- Drug therapy (1)
- Dtherapeutic adherencetreatment integrity (1)
- EROD (1)
- Elderly (1)
- Embryo toxicity (1)
- Endocrinology (1)
- Epilepsy (1)
- European Society for Immunodeficiencies (ESID) (1)
- Everolimus (1)
- Excitability (1)
- Exilliteratur (1)
- Exilschriftsteller (1)
- Exilverlag (1)
- Exosomes (1)
- Extended donor criteria (1)
- FAV00A (1)
- FDG-PET/CT (1)
- FDM (1)
- Femtoscopy (1)
- Filler (1)
- Forschungsdatenmanagement (1)
- Frailty (1)
- Freiligrath, Ferdinand (1)
- Galaxies and clusters (1)
- General practitioners (1)
- Genetic wildlife monitoring (1)
- Genome editing (1)
- Genome-wide association studies (1)
- German PID-NET registry (1)
- Glabella (1)
- Global positioning system (1)
- Guanine nucleotide exchange factors (1)
- Guanosine triphosphatase (1)
- HBT (1)
- HDAC4 (1)
- HER2-positive (1)
- HPV-positive OPSCC (1)
- Hadron production (1)
- Hair sampling (1)
- Head and neck cancer (1)
- Head neck cancer (1)
- Health policy (1)
- Heavy flavor production (1)
- Heavy flavour production (1)
- Heavy ions (1)
- Heavy-flavour production (1)
- Heinzen, Karl (1)
- Herbaria (1)
- High-energy astrophysics (1)
- Human behaviour (1)
- Hypertension (1)
- Hypomethylating agents (1)
- IN-VIVO (1)
- IS (1)
- IgG substitution therapy (1)
- Immunology (1)
- Immunotherapy (1)
- In situ burning (1)
- Inclusive spectra (1)
- Induction therapy (1)
- Inflammation (1)
- Integridad del tratamiento (1)
- Intensity interferometry (1)
- Intravenous injections (1)
- Ions (1)
- Irak (1)
- Islamischer Staat (1)
- Jets (1)
- Kidney diseases (1)
- Knockout (1)
- LOCKED NUCLEIC-ACID (1)
- Landesinitiative (1)
- Landesinitiative für Forschungsdatenmanagement (1)
- Large Hadron Collider (1)
- Lee-type (1)
- Library screening (1)
- Literarisches Institut (Herisau) (1)
- Luciferase (1)
- Lure sticks (1)
- Lymphoid Neoplasia (1)
- MAMMALIAN-CELLS (1)
- MODIFIED OLIGONUCLEOTIDES (1)
- Marker genes (1)
- Mental health and psychiatry (1)
- MicroRNAs (1)
- Microarray (1)
- Microglial cells (1)
- Mid-rapidity (1)
- Mixed hearing loss (1)
- Monte Carlo (1)
- Mott metal-insulator transition (1)
- Mouse models (1)
- Multi-stakeholder approach (1)
- Multi-strange baryons (1)
- NCoR1 (1)
- NFDI (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- Nationale Forschungsdateninfrastruktur (1)
- Nebennierenrinden-Adenom (1)
- Nebennierenrinden-Hyperplasie (1)
- Neoadjuvant therapy (1)
- Neuronal morphology (1)
- Neurons (1)
- Neuroscience (1)
- Noninvasive genetic sampling (1)
- Nuclear modification factor (1)
- Occlusion (1)
- Oldest-old (1)
- Oncology (1)
- Ophthalmoplegia (1)
- Optogenetics (1)
- Organ allocation (1)
- PASSENGER-STRAND (1)
- PID prevalence (1)
- PTS (1)
- PTSD (1)
- PYTHIA (1)
- Pancreas transplantation (1)
- Parkinson disease (1)
- Pathological complete response (1)
- Patterns of care (1)
- Pb–Pb (1)
- Performance of High Energy Physics Detectors (1)
- Perturbative methods (1)
- Phosphorylation (1)
- Pooling (1)
- Population-based screening (1)
- Post-traumatic stress disorder (1)
- Posttraumatic stress disorder (1)
- Proton–proton (1)
- Psychological and psychosocial issues (1)
- Pulmonary embolism (1)
- Quality of life (1)
- RDM (1)
- RNA polymerase (1)
- RT-qPCR (1)
- Radiotherapy (1)
- Randomised controlled trial (1)
- Recall rate (1)
- Red blood cell transfusion (1)
- Referenzwechsel (1)
- Rehabilitation (1)
- Rejection (1)
- Relapse (1)
- Relativistic heavy ion physics (1)
- Research Data Management (1)
- Research Infrastructure (1)
- Retinal diseases (1)
- Revolution <1848> (1)
- Rhabdomyoma (1)
- SENP (1)
- SMALL INTERFERING RNA (1)
- STRUCTURAL BASIS (1)
- SUMO (1)
- Salivary gland carcinoma (1)
- Scattering of atoms, molecules, clusters & ions (1)
- Scattering theory (1)
- Schweiz (1)
- Seizure (1)
- Semantics (1)
- Single muons (1)
- Small molecules (1)
- Spine density (1)
- Sprachtypologie (1)
- Swimming behavior (1)
- Synaptic plasticity (1)
- Syrien (1)
- Systematic Uncertainty (1)
- TEPT (1)
- TGFB-induced factor homeobox 1 (1)
- TGIF (1)
- Taliban (1)
- Taxonomy (1)
- Technical data (1)
- Terapia Dialéctica Conductual (1)
- Tetrahydro-Aldosteron (1)
- Therapeutics (1)
- Time Projection Chamber (1)
- Transverse Momentum (1)
- Transverse momentum (1)
- Trastorno de estrés postraumático (1)
- Triple negative (1)
- Type 2 diabetes (1)
- Venetoclax (1)
- Venous thromboembolism (1)
- Vesicles (1)
- Viral infection (1)
- Wide rapidity coverage (1)
- Yellow fluorescent protein (1)
- adrenal adenomas (1)
- anaemia (1)
- anterior chamber depth changes (1)
- antibiotic therapy (1)
- antibodies (1)
- apex (1)
- ascites (1)
- autoantibodies (1)
- b-cell lymphomas (1)
- bendamustine (1)
- biopsy (1)
- cardiac I/R injury (1)
- cataract surgery (1)
- cetuximab (1)
- charge-cluster glass (1)
- chemotherapy regimen (1)
- chimeric antigen receptor t-cell therapy (1)
- chimeric antigen receptors (1)
- collagen degradation marker (1)
- combined modality therapy (1)
- dentate gyrus (1)
- diabetic macular edema (1)
- dislocation (1)
- double immune checkpoint inhibition (1)
- e-scooter (1)
- effective lens position (1)
- elderly patients (1)
- electric scooter (1)
- fear conditioning (1)
- fluctuation spectroscopy (1)
- fluocinolone acetonide (1)
- fracture (1)
- functional outcome (1)
- glass-like structural ordering (1)
- head and neck neoplasms (1)
- hematopoietic stem cell transplantation (1)
- imaging (1)
- immunoprecipitation (1)
- immunostaining (1)
- immunotherapy (1)
- in situ hybridization (1)
- induction therapy (1)
- lapatinib (1)
- laser microdissection (1)
- learning (1)
- leukapheresis (1)
- liver cirrhosis (1)
- lymphoma (1)
- mTOR inhibitor (1)
- mass spectrometry (1)
- medial prefrontal cortex (mPFC) (1)
- membranous urethra (1)
- memory consolidation and extinction (1)
- microdosing (1)
- mid-term urinary continence (1)
- molecular dynamics simulation (1)
- multidrug resistance (1)
- neoadjuvant therapy (1)
- neutralizing antibodies (1)
- organ preservation (1)
- organic charge-transfer salts (1)
- papilloma (1)
- percolation (1)
- primary aldosteronism (1)
- primary biliary cholangitis (1)
- primary immunodeficiency (PID) (1)
- primärer Hyperaldosteronismus (1)
- prostate cancer (1)
- proteomics (1)
- pseudoexfoliative syndrome (1)
- radical prostatectomy (1)
- re-irradiation (1)
- registry for primary immunodeficiency (1)
- rituximab (1)
- screening routine (1)
- second line therapy (1)
- spectra (1)
- spike protein (1)
- surgery (1)
- tetrahydroaldosterone (1)
- traffic accident (1)
- transcranial magnetic stimulation (TMS) (1)
- transportation (1)
- trastuzumab (1)
- traumatic brain injury (1)
- treatment response (1)
- ursodeoxycholic acid (1)
- variants of concern (1)
- western blotting (1)
- √sN N = 2.76 TeV (1)
- 创伤后应激障碍 (1)
- 治疗依从性 (1)
- 治疗完整性 (1)
- 辩证行为疗法 (1)
Institute
- Physik (114)
- Frankfurt Institute for Advanced Studies (FIAS) (100)
- Informatik (99)
- Medizin (76)
- Geowissenschaften (7)
- Biowissenschaften (5)
- Biochemie und Chemie (4)
- Psychologie (3)
- Senckenbergische Naturforschende Gesellschaft (3)
- ELEMENTS (2)
SUMOylation is a reversible posttranslational modification pathway catalyzing the conjugation of small ubiquitin-related modifier (SUMO) proteins to lysine residues of distinct target proteins. SUMOylation modifies a wide variety of cellular regulators thereby affecting a multitude of key processes in a highly dynamic manner. The SUMOylation pathway displays a hallmark in cellular stress-adaption, such as heat or redox stress. It has been proposed that enhanced cellular SUMOylation protects the brain during ischemia, however, little is known about the specific regulation of the SUMO system and the potential target proteins during cardiac ischemia and reperfusion injury (I/R). By applying left anterior descending (LAD) coronary artery ligation and reperfusion in mice, we detect dynamic changes in the overall cellular SUMOylation pattern correlating with decreased SUMO deconjugase activity during I/R injury. Further, unbiased system-wide quantitative SUMO-proteomics identified a sub-group of SUMO targets exhibiting significant alterations in response to cardiac I/R. Notably, transcription factors that control hypoxia- and angiogenesis-related gene expression programs, exhibit altered SUMOylation during ischemic stress adaptation. Moreover, several components of the ubiquitin proteasome system undergo dynamic changes in SUMO conjugation during cardiac I/R suggesting an involvement of SUMO signaling in protein quality control and proteostasis in the ischemic heart. Altogether, our study reveals regulated candidate SUMO target proteins in the mouse heart, which might be important in coping with hypoxic/proteotoxic stress during cardiac I/R injury.
An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to the current level of investment in their development, particularly in the fields of natural-product-derived and synthetic small molecules. New agents displaying innovative chemistry and modes of action are desperately needed worldwide to tackle the public health menace posed by antimicrobial resistance. Here, our consortium presents a strategic blueprint to substantially improve our ability to discover and develop new antibiotics. We propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding, aiming to bridge the gap between academic, industrial and political stakeholders, and to unite interdisciplinary expertise in order to efficiently fuel the translational pipeline for the benefit of future generations.
From July 2002 to March 2004 the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) aboard the European Space Agency´s Environmental Satellite (Envisat) measured nearly continuously mid infrared limb radiance spectra. These measurements are utilised to retrieve the global distribution of the chlorofluorocarbon CFC-11 by applying a new fast forward model for Envisat MIPAS and an accompanying optimal estimation retrieval processor. A detailed analysis shows that the total retrieval errors of the individual CFC-11 volume mixing ratios are typically below 10% in the altitude range 10 to 25 km and that the systematic components dominate. Contribution of a priori information to the retrieval results are less than 5 to 10% and the vertical resolution of the observations is about 3 to 4 km in the same vertical range. The data are successfully validated by comparison with several other space experiments, an air-borne in-situ instrument, measurements from ground-based networks, and independent Envisat MIPAS analyses. The retrieval results from 425 000 Envisat MIPAS limb scans are compiled to provide a new climatological data set of CFC-11. The climatology shows significantly lower CFC-11 abundances in the lower stratosphere compared with the Reference Atmospheres for MIPAS (RAMstan V3.1) climatology. Depending on the atmospheric conditions the differences between the climatologies are up to 30 to 110 ppt (45 to 150%) at 19 to 27 km altitude. Additionally, time series of CFC-11 mean abundance and variability for five latitudinal bands are presented. The observed CFC-11 distributions can be explained by the residual mean circulation and large-scale eddy-transports in the upper troposphere and lower stratosphere. The new CFC-11 data set is well suited for further scientific studies.
Background: Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. The purpose of the study is to evaluate whether elderly surgical patients may benefit from a liberal red blood cell (RBC) transfusion strategy compared to a restrictive transfusion strategy.
Methods: The LIBERAL Trial is a prospective, randomized, multicentre, controlled clinical phase IV trial randomising 2470 elderly (≥ 70 years) patients undergoing intermediate- or high-risk non-cardiac surgery. Registered patients will be randomised only if Haemoglobin (Hb) reaches ≤9 g/dl during surgery or within 3 days after surgery either to the LIBERAL group (transfusion of a single RBC unit when Hb ≤ 9 g/dl with a target range for the post-transfusion Hb level of 9–10.5 g/dl) or the RESTRICTIVE group (transfusion of a single RBC unit when Hb ≤ 7.5 g/dl with a target range for the post-transfusion Hb level of 7.5–9 g/dl). The intervention per patient will be followed until hospital discharge or up to 30 days after surgery, whichever occurs first. The primary efficacy outcome is defined as a composite of all-cause mortality, acute myocardial infarction, acute ischaemic stroke, acute kidney injury (stage III), acute mesenteric ischaemia and acute peripheral vascular ischaemia within 90 days after surgery. Infections requiring iv antibiotics with re-hospitalisation are assessed as important secondary endpoint. The primary endpoint will be analysed by logistic regression adjusting for age, cancer surgery (y/n), type of surgery (intermediate- or high-risk), and incorporating centres as random effect.
Discussion: The LIBERAL-Trial will evaluate whether a liberal transfusion strategy reduces the occurrence of major adverse events after non-cardiac surgery in the geriatric population compared to a restrictive strategy within 90 days after surgery.
Trial registration: ClinicalTrials.gov (identifier: NCT03369210).
Chlorine monoxide (ClO) plays a key role in stratospheric ozone loss processes at midlatitudes. We present two balloonborne in situ measurements of ClO conducted in northern hemisphere midlatitudes during the period of the maximum of total inorganic chlorine loading in the atmosphere. Both ClO measurements were conducted on board the TRIPLE balloon payload, launched in November 1996 in Le´on, Spain, and in May 1999 in Aire sur l’Adour, France. For both flights a ClO daylight and night time vertical profile could be derived over an altitude range of approximately 15–31 km. ClO mixing ratios are compared to model simulations performed with the photochemical box model version of the Chemical Lagrangian Model of the Stratosphere (CLaMS). Simulations along 24-h backward trajectories were performed to study the diurnal variation of ClO in the midlatitude lower stratosphere. Model simulations for the flight launched in Aire sur l’Adour 1999 show a good agreement with the ClO measurements. For the flight launched in Le´on 1996, a similar good agreement is found, except at around ~ 650 K potential temperature (~26km altitude). However, a tendency is found that for solar zenith angles greater than 86°–87° the simulated ClO mixing ratios substantially overestimate measured ClO by approximately a factor of 2.5 or more for both flights. Therefore we conclude that no indication can be deduced from the presented ClO measurements that substantial uncertainties exist in midlatitude chlorine chemistry of the stratosphere. An exception is the situation at solar zenith angles greater than 86°–87° where model simulations substantial overestimate ClO observations.
Chlorine monoxide (ClO) plays a key role in stratospheric ozone loss processes at midlatitudes. We present two balloon-borne in situ measurements of ClO conducted in northern hemisphere midlatitudes during the period of the maximum of total inorganic chlorine loading in the atmosphere. Both ClO measurements were conducted on board the TRIPLE balloon payload, launched in November 1996 in León, Spain, and in May 1999 in Aire sur l'Adour, France. For both flights a ClO daylight and night-time vertical profile was derived over an altitude range of approximately 15-35 km. ClO mixing ratios are compared to model simulations performed with the photochemical box model version of the Chemical Lagrangian Model of the Stratosphere (CLaMS). Simulations along 24-hour backward trajectories were performed to study the diurnal variation of ClO in the midlatitude lower stratosphere. Model simulations for the flight launched in Aire sur l'Adour 1999 show an excellent agreement with the ClO measurements. For the flight launched in León 1996, an overall good agreement is found, whereas the flight is characterized by a more complex dynamical situation due to a possible mixture of vortex and non-vortex air. We note that for both flights at solar zenith angles greater than 86°-87° simulated ClO mixing ratios are higher than observed ClO mixing ratios. However, the present findings indicate that no substantial uncertainties exist in midlatitude chlorine chemistry of the stratosphere.
Endocannabinoids are important lipid-signaling mediators. Both protective and deleterious effects of endocannabinoids in the cardiovascular system have been reported but the mechanistic basis for these contradicting observations is unclear. We set out to identify anti-inflammatory mechanisms of endocannabinoids in the murine aorta and in human vascular smooth muscle cells (hVSMC). In response to combined stimulation with cytokines, IL-1β and TNFα, the murine aorta released several endocannabinoids, with anandamide (AEA) levels being the most significantly increased. AEA pretreatment had profound effects on cytokine-induced gene expression in hVSMC and murine aorta. As revealed by RNA-Seq analysis, the induction of a subset of 21 inflammatory target genes, including the important cytokine CCL2 was blocked by AEA. This effect was not mediated through AEA-dependent interference of the AP-1 or NF-κB pathways but rather through an epigenetic mechanism. In the presence of AEA, ATAC-Seq analysis and chromatin-immunoprecipitations revealed that CCL2 induction was blocked due to increased levels of H3K27me3 and a decrease of H3K27ac leading to compacted chromatin structure in the CCL2 promoter. These effects were mediated by recruitment of HDAC4 and the nuclear corepressor NCoR1 to the CCL2 promoter. This study therefore establishes a novel anti-inflammatory mechanism for the endogenous endocannabinoid AEA in vascular smooth muscle cells. Furthermore, this work provides a link between endogenous endocannabinoid signaling and epigenetic regulation.
Purpose: Filler injections for aesthetic purposes are very popular, but can have far-reaching and irreversible consequences. This report describes the course of a patient with devastating complications after glabellar hyaluronic acid injection, their pathomechanism, management and outcome.
Observations: A healthy, 43-year-old woman underwent her first hyaluronic acid injection in the glabella and went blind on her left eye immediately thereafter. Massaging of the injection area and observation were performed, before she presented with swelling of the left forehead and upper lid, ptosis, complete ophthalmoplegia and blindness in our hospital. Immediate massaging of the globe and systemic therapy including acetylsalicylic acid, tinzaparin sodium and cortisone was initiated and hyaluronidase injections in the injection area were performed. In the further course, the patient developed necrotic and hemorrhagic skin and mucosal lesions, lagophthalmos, anterior and posterior segment ischemia and globe hypotonia with consecutive globe deformation. In the follow-up of 2.5 months, lid swelling, lagophthalmos and ptosis resolved and keratopathy improved but blindness, skin lesions and strabismus with reduced eye motility were still present and madarosis and early enophthalmos were detected.
Conclusions and Importance: The outcome of ophthalmic artery occlusion after hyaluronic acid filler injection is poor. Sufficient knowledge about facial anatomy, the implementation of filler injections and the management of complications is essential for the practitioner. The patient should be clarified about potential and even rare risks of these procedures.
Eine Annäherung an die Sozialgeschichte der Exilliteratur muss verschiedene Faktoren beachten, die die Struktur des komplexen kommunikativen Systems der Exilliteratur bestimmen: erstens die Beziehungen zwischen den politischen Verlagen und den Exilautoren in der Schweiz; zweitens die Verbindungen innerhalb der Exilliteratenszene, zwischen den Verlagen und den Autoren sowie zwischen den Autoren und ihren Werken; drittens die Beziehungen zwischen den Massnahmen in den deutschen Staaten gegen den Schriftenschmuggel und den Folgen, die die Exilliteratur auf
die dortige Pressepolitik hatte; und viertens die innen- und aussenpolitischen Verflechtungen zwischen der Schweizer Flüchtlings- und Pressepolitik, den diplomatischen Druckversuchen des Auslands und den Vorgehensweisen der Kantone gegen die Verlage und die politischen Flüchtlinge. Diese Faktoren beeinflussen sich wechselseitig und bilden
ein "unendliches Netz spezifisch gesellschaftlicher Verflechtungen zwischen Autor und Verleger, Herausgeber und Kritiker, Verflechtungen der Autoren untereinander etc." [Bourdieu]. Im Folgenden sollen am Beispiel des "Literarischen Instituts" und der beiden Exilliteraten Freiligrath und Heinzen einige der eben aufgezählten Faktoren und Elemente des exilliterarischen Feldes aufgezeigt werden.