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Institute
The Born cross sections for the process e+e−→η′π+π− at different center-of-mass energies between 2.00 and 3.08~GeV are reported with improved precision from an analysis of data samples collected with the BESIII detector operating at the BEPCII storage ring. An obvious structure is observed in the Born cross section line shape. Fit as a Breit-Wigner resonance, it has a statistical significance of 6.3σ and a mass and width of M=(2108±46±25)~MeV/c2 and Γ=(138±36±30)~MeV, where the uncertainties are statistical and systematic, respectively. These measured resonance parameters agree with the measurements of BABAR in e+e−→η′π+π− and BESIII in e+e−→ωπ0 within two standard deviations.
The process 𝑒+𝑒−→𝜙𝜂′ has been studied for the first time in detail using data sample collected with the BESIII detector at the BEPCII collider at center of mass energies from 2.05 to 3.08 GeV. A resonance with quantum numbers 𝐽𝑃𝐶=1−− is observed with mass 𝑀=(2177.5±4.8(stat)±19.5(syst))MeV/𝑐2 and width Γ=(149.0±15.6(stat)±8.9(syst)) MeV with a statistical significance larger than 10𝜎, including systematic uncertainties. If the observed structure is identified with the 𝜙(2170), then the ratio of partial width between the 𝜙𝜂′ by BESIII and 𝜙𝜂 by BABAR is (ℬ𝑅𝜙𝜂Γ𝑅𝑒𝑒)/(ℬ𝑅𝜙𝜂′Γ𝑅𝑒𝑒)=0.23±0.10(stat)±0.18(syst), which is smaller than the prediction of the 𝑠¯𝑠𝑔 hybrid models by several orders of magnitude.
Using inclusive decays of the J/ψ, a precise determination of the number of J/ψ events collected with the BESIII detector is performed. For the two data sets taken in 2009 and 2012, the numbers of J/ψ events are recalculated to be (224.0±1.3)×106 and (1088.5±4.4)×106 respectively, which are in good agreement with the previous measurements. For the J/ψ sample taken in 2017--2019, the number of events is determined to be (8774.0±39.4)×106. The total number of J/ψ events collected with the BESIII detector is determined to be (10087±44)×106, where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible.
The integrated luminosities of the data samples collected in the BESIII experiment in 2016--2017 at center-of-mass energies between 4.19 and 4.28 GeV are measured with a precision better than 1% by analyzing large-angle Bhabha scattering events. The integrated luminosities of the old data sets collected in 2010--2014 are updated by considering correction related to the detector performance, offsettting the effect of newly discovered readout errors in the electromagnetic calorimeter that happen haphazardly.
We report an amplitude analysis and branching fraction measurement of 𝐷+
𝑠→𝐾+𝐾−𝜋+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV. We perform a model-independent partial wave analysis in the low 𝐾+𝐾− mass region to determine the 𝐾+𝐾− S-wave line shape, followed by an amplitude analysis of our very pure high-statistics sample. With the detection efficiency based on the amplitude analysis results, the absolute branching fraction is measured to be ℬ(𝐷+𝑠→𝐾+𝐾−𝜋+)=(5.47±0.08stat±0.13sys)%.
Using a data sample corresponding to an integrated luminosity of 2.93 fb−1 collected at a center-of-mass energy s√=3.773 GeV by the BESIII detector, the decay D0→ωϕ is observed for the first time. The branching fraction is measured to be (6.48±0.96±0.38)×10−4 with a significance of 6.3σ, where the first and second uncertainties are statistical and systematic, respectively. An angular analysis reveals that the ϕ and ω mesons from the D0→ωϕ decay are transversely polarized.
Based on (10087±44)×106 J/ψ events collected with the BESIII detector, the process J/ψ→γπ+π−η′ is studied using two dominant decay channels of the η′ meson, η′→γπ+π− and η′→ηπ+π−,η→γγ. The X(2600) is observed with a statistical significance larger than 20σ in the π+π−η′ invariant mass spectrum, and it has a strong correlation to a structure around 1.5 GeV/{\it c}2 in the π+π− invariant mass spectrum. A simultaneous fit on the π+π−η′ and π+π− invariant mass spectra with the two η′ decay modes indicates that the mass and width of the X(2600) state are 2617.8±2.1+18.2−1.9 MeV/{\it c}2 and 200±8+20−17 MeV, respectively. The corresponding branching fractions are measured to be B(J/ψ→γX(2600))⋅B(X(2600)→f0(1500)η′)⋅B(f0(1500)→π+π−) = (3.39±0.18+0.91−0.66)×10−5 and B(J/ψ→γX(2600))⋅B(X(2600)→f′2(1525)η′)⋅B(f′2(1525)→π+π−) = (2.43±0.13+0.31−1.11)×10−5, where the first uncertainties are statistical, and the second systematic.
Using inclusive decays of the J/ψ, a precise determination of the number of J/ψ events collected with the BESIII detector is performed. For the two data sets taken in 2009 and 2012, the numbers of J/ψ events are recalculated to be (224.0±1.3)×106 and (1088.5±4.4)×106 respectively, which are in good agreement with the previous measurements. For the J/ψ sample taken in 2017--2019, the number of events is determined to be (8774.0±39.4)×106. The total number of J/ψ events collected with the BESIII detector is determined to be (10087±44)×106, where the uncertainty is dominated by systematic effects and the statistical uncertainty is negligible.
During the 2016-17 and 2018-19 running periods, the BESIII experiment collected 7.5 fb -1 of e+e− collision data at center-of-mass energies ranging from 4.13 to 4.44 GeV. These data samples are primarily used for the study of excited charmonium and charmoniumlike states. By analyzing the di-muon process e+e− (γISR/FSR)µ -> +µ-, we measure the center-of-mass energies of the data samples with a precision of 0.6 MeV. Through a run-by-run study, we find that the center-of-mass energies were stable throughout most of the data-collection period.
We report an amplitude analysis and branching fraction measurement of D+s→K+K−π+ decay using a data sample of 3.19 fb−1 recorded with BESIII detector at a center-of-mass energy of 4.178 GeV.
We perform a model-independent partial wave analysis in the low K+K− mass region to determine the K+K− S-wave lineshape,
followed by an amplitude analysis of our very pure high-statistics sample.
The amplitude analysis provides an accurate determination of the detection efficiency allowing us to measure the branching fraction B(D+s→K+K−π+)=(5.47±0.08stat±0.13sys)%.
Measurement of cross sections for e⁺e⁻ → μ⁺μ⁻ at center-of-mass energies from 3.80 to 4.60 GeV
(2020)
The observed cross sections for 𝑒+𝑒−→𝜇+𝜇− at energies from 3.8 to 4.6 GeV are measured using data samples taken with the BESIII detector operated at the BEPCII collider. We measure the muonic widths and determine the branching fractions of the charmonium states 𝜓(4040), 𝜓(4160), and 𝜓(4415) decaying to 𝜇+𝜇−, as well as making a first determination of the phase of the amplitudes. In addition, we observe evidence for a structure in the dimuon cross section near 4.220 GeV/𝑐2, which we denote as 𝑆(4220). Analyzing a coherent sum of amplitudes yields eight solutions, one of which gives a mass of 𝑀𝑆(4220) = 4216.7±8.9±4.1 MeV/𝑐2, a total width of Γtot S(4220) = 47.2±22.8±10.5 MeV, and a muonic width of Γ𝜇𝜇 𝑆(4220) = 1.53±1.26±0.54 keV, where the first uncertainties are statistical and the second systematic. The eight solutions give the central values of the mass, total width, muonic width to be, respectively, in the range from 4212.8 to 4219.4 MeV/𝑐2, from 36.4 to 49.6 MeV, and from 1.09 to 1.53 keV. The statistical significance of the 𝑆(4220) signal is 3.9𝜎. Correcting the total dimuon cross section for radiative effects yields a statistical significance for this structure of 8.1𝜎.
Background: Biological psychiatry aims to understand mental disorders in terms of altered neurobiological pathways. However, for one of the most prevalent and disabling mental disorders, Major Depressive Disorder (MDD), patients only marginally differ from healthy individuals on the group-level. Whether Precision Psychiatry can solve this discrepancy and provide specific, reliable biomarkers remains unclear as current Machine Learning (ML) studies suffer from shortcomings pertaining to methods and data, which lead to substantial over-as well as underestimation of true model accuracy.
Methods: Addressing these issues, we quantify classification accuracy on a single-subject level in N=1,801 patients with MDD and healthy controls employing an extensive multivariate approach across a comprehensive range of neuroimaging modalities in a well-curated cohort, including structural and functional Magnetic Resonance Imaging, Diffusion Tensor Imaging as well as a polygenic risk score for depression.
Findings Training and testing a total of 2.4 million ML models, we find accuracies for diagnostic classification between 48.1% and 62.0%. Multimodal data integration of all neuroimaging modalities does not improve model performance. Similarly, training ML models on individuals stratified based on age, sex, or remission status does not lead to better classification. Even under simulated conditions of perfect reliability, performance does not substantially improve. Importantly, model error analysis identifies symptom severity as one potential target for MDD subgroup identification.
Interpretation: Although multivariate neuroimaging markers increase predictive power compared to univariate analyses, single-subject classification – even under conditions of extensive, best-practice Machine Learning optimization in a large, harmonized sample of patients diagnosed using state-of-the-art clinical assessments – does not reach clinically relevant performance. Based on this evidence, we sketch a course of action for Precision Psychiatry and future MDD biomarker research.
By analyzing 6.32 fb − 1 of e+ e− annihilation data collected at the center-of-mass energies between 4.178 and 4.226 GeV with the BESIII detector, we determine the branching fraction of the leptonic decay D + s → τ + ντ, with τ+ → π + π0¯ντ, to be B D + s → τ + ν τ = (5.29 ± 0.25 stat ± 0.20 syst) %. We estimate the product of the Cabibbo-Kobayashi-Maskawa matrix element |Vcs|and the D + s decay constant f D + s to be f D + s|Vcs| = (244.8 ± 5.8 stat ± 4.8syst) MeV, using the known values of the τ + and D + s masses as well as the D + s lifetime, together with our branching fraction measurement. Combining the value of |Vcs| obtained from a global fit in the standard model and f D + s from lattice quantum chromodynamics, we obtain f D + s = (251.6 ± 5.9 stat ± 4.9syst) MeV and |Vcs| = 0.980 ± 0.023 stat ± 0.019 syst. Using the branching fraction of B D + s → μ + νμ = (5.35±0.21)×10−3, we obtain the ratio of the branching fractions B D + s → τ + ντ/B D +s → μ+νμ = 9.89±0.71, which is consistent with the standard model prediction of lepton flavor universality.
Using a sample of (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector, we perform the first partial wave analysis of ψ(3686)→K+K−η. In addition to the well established states, ϕ(1020), ϕ(1680), and K∗3(1780), contributions from X(1750), ρ(2150), ρ3(2250), and K∗2(1980) are also observed. The X(1750) state is determined to be a 1−− resonance. The simultaneous observation of the ϕ(1680) and X(1750) indicates that the X(1750), with previous observations in photoproduction, is distinct from the ϕ(1680). The masses, widths, branching fractions of ψ(3686)→K+K−η and the intermediate resonances are also measured.
We measured the branching fractions of the decays χcJ→Σ−Σ¯+ for the first time using the final states nn¯π+π−. The data sample exploited here is 448.1×106 ψ(3686) events collected with BESIII. We find B(χcJ→Σ−Σ¯+)=(51.3±2.4±4.1)×10−5,(5.7±1.4±0.6)×10−5,and (4.4±1.7±0.5)×10−5, for J=0,1,2, respectively, where the first uncertainties are statistical and the second systematic.
The change in allele frequencies within a population over time represents a fundamental process of evolution. By monitoring allele frequencies, we can analyze the effects of natural selection and genetic drift on populations. To efficiently track time-resolved genetic change, large experimental or wild populations can be sequenced as pools of individuals sampled over time using high-throughput genome sequencing (called the Evolve & Resequence approach, E&R). Here, we present a set of experiments using hundreds of natural genotypes of the model plant Arabidopsis thaliana to showcase the power of this approach to study rapid evolution at large scale. First, we validate that sequencing DNA directly extracted from pools of flowers from multiple plants -- organs that are relatively consistent in size and easy to sample -- produces comparable results to other, more expensive state-of-the-art approaches such as sampling and sequencing of individual leaves. Sequencing pools of flowers from 25-50 individuals at ∼40X coverage recovers genome-wide frequencies in diverse populations with accuracy r > 0.95. Secondly, to enable analyses of evolutionary adaptation using E&R approaches of plants in highly replicated environments, we provide open source tools that streamline sequencing data curation and calculate various population genetic statistics two orders of magnitude faster than current software. To directly demonstrate the usefulness of our method, we conducted a two-year outdoor evolution experiment with A. thaliana to show signals of rapid evolution in multiple genomic regions. We demonstrate how these laboratory and computational Pool-seq-based methods can be scaled to study hundreds of populations across many climates.
Using a sample of (10.09±0.04)×109 J/ψ events collected with the BESIII detector operating at the BEPCII storage ring, a partial wave analysis of the decay J/ψ→γηη′ is performed. The first observation of an isoscalar state with exotic quantum numbers JPC=1−+, denoted as η1(1855), is reported in the process J/ψ→γη1(1855) with η1(1855)→ηη′. Its mass and width are measured to be (1855±9+6−1)MeV/c2 and (188±18+3−8)MeV, respectively, where the first uncertainties are statistical and the second are systematic, and its statistical significance is estimated to be larger than 19σ.
Using a sample of 1.31×109 J/ψ events collected by the BESIII detector at BEPCII during 2009 and 2012, we study the J/ψ→ωη′π+π− hadronic process. For the first time, we measure the branching ratio B(J/ψ→ωη′π+π−)=(1.12±0.02±0.13)×10−3. We search for the X(1835) state in the η′π+π− invariant mass spectra. No evidence is found and we estimate the upper limit on the branching fraction at 90% confidence level to be B(J/ψ→ωX(1835),X(1835)→η′π+π−)<6.2×10−5.
The cross sections of the process e+e−→K0SK0L are measured at fifteen center-of-mass energies s√ from 2.00 to 3.08 GeV with the BESIII detector at the Beijing Electron Positron Collider (BEPCII). The results are found to be consistent with those obtained by BaBar. A resonant structure around 2.2 GeV is observed, with a mass and width of 2273.7±5.7±19.3 MeV/c2 and 86±44±51 MeV, respectively, where the first uncertainties are statistical and the second ones are systematic. The product of its radiative width (Γe+e−) with its branching fraction to K0SK0L (BrK0SK0L) is 0.9±0.6±0.7 eV.
Based on 14.7 fb−1 of e+e− annihilation data collected with the BESIII detector at the BEPCII collider at 17 different center-of-mass energies between 3.7730 GeV and 4.5995 GeV, Born cross sections of the two processes e+e−→pp¯η and e+e−→pp¯ω are measured for the first time. No indication of resonant production through a vector state V is observed, and upper limits on the Born cross sections of e+e−→V→pp¯η and e+e−→V→pp¯ω at the 90% confidence level are calculated for a large parameter space in resonance masses and widths. For the current world average parameters of the ψ(4230) of m=4.2187 GeV/c2 and Γ=44 MeV, we find upper limits on resonant production of the pp¯η and pp¯ω final states of 7.5 pb and 10.4 pb at the 90% CL, respectively.
Several intermediate states of the reaction channels 𝑒+𝑒−→𝜋+𝜋−𝐷0¯𝐷0 and 𝑒+𝑒−→𝜋+𝜋−𝐷+𝐷− are studied using the data samples collected with the BESIII detector at center-of-mass energies above 4.08 GeV. For the first time in this final state, a 𝜓(3770) signal is seen in the 𝐷¯𝐷 invariant mass spectrum, with a statistical significance of 5.2𝜎 at √𝑠=4.42 GeV. There is also evidence for this resonance at √𝑠=4.26 and 4.36 GeV with statistical significance of 3.2𝜎 and 3.3𝜎, respectively. In addition, the Born cross section of 𝑒+𝑒−→𝜋+𝜋−𝜓(3770) is measured. The proposed heavy-quark-spin-symmetry partner of the 𝑋(3872), the state 𝑋2(4013), is also searched for in the 𝐷¯𝐷 invariant mass spectra. No obvious signal is found. The upper limit of the Born cross section of the process 𝑒+𝑒−→𝜌0𝑋2(4013) combined with the branching fraction is measured. Also, the processes 𝑒+𝑒−→𝐷1(2420)¯𝐷+c.c. are investigated. The neutral mode with 𝐷1(2420)0→𝐷0𝜋+𝜋− is reported with statistical significance of 7.4𝜎 at √𝑠=4.42 GeV for the first time, and evidence with statistical significance of 3.2𝜎 and 3.3𝜎 at √𝑠=4.36 and 4.60 GeV is seen, respectively. No evident signal for the process 𝑒+𝑒−→𝐷1(2420)0¯𝐷0+c.c.,𝐷1(2420)0→𝐷*+𝜋− is reported. Evidence for 𝑒+𝑒−→𝐷1(2420)+𝐷−+c.c.,𝐷1(2420)+→𝐷+𝜋+𝜋− is reported with statistical significance of 3.1𝜎 and 3.0𝜎 at √𝑠=4.36 and 4.42 GeV, respectively.
Using the data samples collected in the energy range from 3.773 to 4.600 GeV with the BESIII detector at the BEPCII collider, we measure the dressed cross sections as a function of center-of-mass energy for 𝑒+𝑒−→𝐾+𝐾−𝜋+𝜋−(𝜋0), 𝐾+𝐾−𝐾+𝐾−(𝜋0), 𝜋+𝜋−𝜋+𝜋−(𝜋0), and 𝑝¯𝑝𝜋+𝜋−(𝜋0). The cross sections for 𝑒+𝑒−→𝐾+𝐾−𝐾+𝐾−𝜋0, 𝑝¯𝑝𝜋+𝜋−(𝜋0) are the first measurements. Cross sections for the other five channels are much more precise than previous results in this energy region. We also search for charmonium and charmonium-like resonances, such as the 𝑌(4230), decaying into the same final states. We find evidence of the 𝜓(4040) decaying to 𝜋+𝜋−𝜋+𝜋−𝜋0 with a statistical significance of 3.6𝜎. Upper limits are provided for other decays since no clear signals are observed.
The SU(3)-flavor violating decay J/ψ→Ξ(1530)−Ξ¯++c.c. is studied using (1310.6±7.0)×106 J/ψ events collected with the BESIII detector at BEPCII and the branching fraction is measured to be B(J/ψ→Ξ(1530)−Ξ¯++c.c.) = (3.17±0.02stat.±0.08syst.)×10−4. This is consistent with previous measurements with an improved precision. The angular parameter for this decay is measured for the first time and is found to be α=−0.21±0.04stat.±0.06syst.. In addition, we report evidence for the radiative decay Ξ(1530)−→γΞ− with a significance of 3.9σ, including the systematic uncertainties. The 90\% confidence level upper limit on the branching fraction is determined to be B(Ξ(1530)−→γΞ−)≤3.7\%.
Using data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies from 4.178 to 4.600 GeV, we study the process eþe− → π0Xð3872Þγ and search for Zcð4020Þ0 → Xð3872Þγ. We find no significant signal and set upper limits on σðeþe− → π0Xð3872ÞγÞ · BðXð3872Þ → πþπ−J=ψÞ and σðeþe− → π0Zcð4020Þ0Þ · BðZcð4020Þ0 → Xð3872ÞγÞ · BðXð3872Þ → πþπ−J=ψÞ for each energy point at 90% confidence level, which is of the order of several tenths pb.
The electromagnetic process is studied with the initial-state-radiation technique using 7.5 fb−1 of data collected by the BESIII experiment at seven energy points from 3.773 to 4.600 GeV. The Born cross section and the effective form factor of the proton are measured from the production threshold to 3.0 GeV/ using the invariant-mass spectrum. The ratio of electric and magnetic form factors of the proton is determined from the analysis of the proton-helicity angular distribution.
Based on a sample of (10.09±0.04)×109 J/ψ events collected with the BESIII detector operating at the BEPCII storage ring, a partial wave analysis of the decay J/ψ→γηη′ is performed. An isoscalar state with exotic quantum numbers JPC=1−+, denoted as η1(1855), has been observed for the first time with statistical significance larger than 19σ. Its mass and width are measured to be (1855±9+6−1)~MeV/c2 and (188±18+3−8)~MeV, respectively. The product branching fraction B(J/ψ→γη1(1855)→γηη′) is measured to be (2.70±0.41+0.16−0.35)×10−6. The first uncertainties are statistical and the second are systematic. In addition, an upper limit on the branching ratio B(f0(1710)→ηη′)/B(f0(1710)→ππ) is determined to be 1.61×10−3 at 90\% confidence level, which lends support to the hypothesis that the f0(1710) has a large glueball component.
Analyzing (448.1±2.9)×106 ψ(3686) events collected with the BESIII detector at the BEPCII collider, the ψ(3686)→ωK0SK0S decay is observed for the first time. The branching fraction for this decay is determined to be Bψ(3686)→ωK0SK0S=(7.04±0.39±0.36)×10−5, where the first uncertainty is statistical and the second is systematic.
Relative fractions and phases of the intermediate decays are determined. With the detection efficiency estimated by the results of the amplitude analysis, the branching fraction of Dþ s → K−Kþπþπ0 decay is measured to be ð5.42 0.10stat 0.17systÞ%.
Using a total of 11.0 fb−1 of e+e− collision data with center-of-mass energies between 4.009 GeV and 4.6 GeV and collected with the BESIII detector at BEPCII, we measure fifteen exclusive cross sections and effective form factors for the process e+e−→Ξ−Ξ¯+ by means of a single baryon-tag method. After performing a fit to the dressed cross section of e+e−→Ξ−Ξ¯+, no significant ψ(4230) or ψ(4260) resonance is observed in the Ξ−Ξ¯+ final states, and upper limits at the 90\% confidence level on ΓeeB for the processes ψ(4230)/ψ(4260)→Ξ−Ξ¯+ are determined. In addition, an excited Ξ baryon at 1820 MeV/c2 is observed with a statistical significance of 6.2 ∼ 6.5σ by including the systematic uncertainty, and the mass and width are measured to be M=(1825.5±4.7±4.7)~MeV/c2 and Γ=(17.0±15.0±7.9)~MeV, which confirms the existence of the JP=32− state Ξ(1820).
We report a measurement of the observed cross sections of e+ e− → J/ψX based on 3.21 fb − 1 of data accumulated at energies from 3.645 to 3.891 GeV with the BESIII detector operated at the BEPCII collider. In analysis of the cross sections, we measured the decay branching fractions of B(ψ(3686) → J/ψX) = (64.4 ± 0.6 ± 1.6)% and B(ψ(3770) → J/ψX) = (0.5 ± 0.2 ± 0.1)% for the first time. The energy-dependent line shape of these cross sections cannot be well described by two Breit-Wigner (BW) amplitudes of the expected decays ψ (3686) → J/ψX and ψ(3770) → J/ψX. Instead, it can be better described with one more BW amplitude of the decay R(3760)→ J/ψX. Under this assumption, we extracted the R (3760) mass M R (3760 ) = 3766.2 ± 3.8 ± 0.4 MeV/c2, total width Γ tot R ( 3760 ) = 22.2 ± 5.9 ± 1.4 MeV, and product of leptonic width and decay branching fraction
ΓeeR(3760) B[R(3760) → J/ψX] = (79.4 ± 85.5 ± 11.7) eV. The significance of the R(3760) is 5.3σ. The first uncertainties of these measured quantities are from fits to the cross sections and second systematic.
By analyzing an e+e− annihilation data sample with an integrated luminosity of 2.93 fb−1 taken at the center-of-mass energy of 3.773 GeV with the BESIII detector, we determine the absolute branching fractions of the hadronic decays D0→K−π+ω, D0→K0Sπ0ω, and D+→K0Sπ+ω to be (3.392±0.044stat±0.085syst)%, (0.848±0.046stat±0.031syst)%, and (0.707±0.041stat±0.029syst)%, respectively. The accuracy of the branching fraction measurement of the decay D0→K−π+ω is improved by a factor of seven compared to the world average value. The D0→K0Sπ0ω and D+→K0Sπ+ω decays are observed for the first time.
Using a total of 9.0 fb−1 of e+e− collision data with center-of-mass energies between 4.15 and 4.30 GeV collected by the BESIII detector, we search for the processes e+e−→γX(3872) with X(3872)→π0χcJ for J=0,1,2. We report the first observation of X(3872)→π0χc1, a new decay mode of the X(3872), with a statistical significance of more than 5σ. Normalizing to the previously established process e+e−→γX(3872) with X(3872)→π+π−J/ψ, we find B(X(3872)→π0χc1)/B(X(3872)→π+π−J/ψ)=0.88+0.33−0.27±0.10, where the first error is statistical and the second is systematic. We set 90% confidence level upper limits on the corresponding ratios for the decays to π0χc0 and π0χc2 of 19 and 1.1, respectively.
Study of the decay Dₛ⁺ → π⁺π⁺π⁻η and observation of the W-annihilation decay Dₛ⁺ → a₀(980)⁺ρ⁰
(2021)
The decay 𝐷+𝑠→𝜋+𝜋+𝜋−𝜂 is observed for the first time, using 𝑒+𝑒− collision data corresponding to an integrated luminosity of 6.32 fb−1, collected by the BESIII detector at center-of-mass energies between 4.178 and 4.226 GeV. The absolute branching fraction for this decay is measured to be ℬ(𝐷+𝑠→𝜋+𝜋+𝜋−𝜂)=(3.12±0.13stat±0.09syst)%. The first amplitude analysis of this decay reveals the substructures in 𝐷+𝑠→𝜋+𝜋+𝜋−𝜂 and determines the relative fractions and the phases among these substructures. The dominant intermediate process is 𝐷+𝑠→𝑎1(1260)+𝜂,𝑎1(1260)+→𝜌(770)0𝜋+ with a branching fraction of (1.73±0.14stat±0.08syst)%. We also observe the 𝑊-annihilation process 𝐷+𝑠→𝑎0(980)+𝜌(770)0, 𝑎0(980)+→𝜋+𝜂 with a branching fraction of (0.21±0.08stat±0.05syst)%, which is larger than the branching fractions of other measured pure 𝑊-annihilation decays by 1 order of magnitude.
The singly Cabibbo-suppressed decay Λ+c→nπ+ is observed for the first time with a statistical significance of 7.3σ by using 3.9 fb−1 of e+e− collision data collected at center-of-mass energies between 4.612 and 4.699 GeV with the BESIII detector at BEPCII. The branching fraction of Λ+c→nπ+ is measured to be (6.6±1.2stat±0.4syst)×10−4. By taking the upper limit of branching fractions of Λ+c→pπ0 from the Belle experiment, the ratio of branching fractions between Λ+c→nπ+ and Λ+c→pπ0 is calculated to be larger than 7.2 at the 90% confidence level, which disagrees with the current predictions of available phenomenological models. In addition, the branching fractions of the Cabibbo-favored decays Λ+c→Λπ+ and Λ+c→Σ0π+ are measured to be (1.31±0.08stat±0.05syst)×10−2 and (1.22±0.08stat±0.07syst)×10−2, respectively, which are consistent with previous results.
The singly Cabibbo-suppressed decay Λ+c→nπ+ is observed for the first time with a statistical significance of 7.3σ by using 3.9 fb−1 of e+e− collision data collected at center-of-mass energies between 4.612 and 4.699 GeV with the BESIII detector at BEPCII. The branching fraction of Λ+c→nπ+ is measured to be (6.6±1.2stat±0.4syst)×10−4. By taking the upper limit of branching fractions of Λ+c→pπ0 from the Belle experiment, the ratio of branching fractions between Λ+c→nπ+ and Λ+c→pπ0 is calculated to be larger than 7.2 at the 90% confidence level, which disagrees with the current predictions of available phenomenological models. In addition, the branching fractions of the Cabibbo-favored decays Λ+c→Λπ+ and Λ+c→Σ0π+ are measured to be (1.31±0.08stat±0.05syst)×10−2 and (1.22±0.08stat±0.07syst)×10−2, respectively, which are consistent with previous results.
The singly Cabibbo-suppressed decay Λ+c→nπ+ is observed for the first time with a statistical significance of 7.3σ by using 3.9 fb−1 of e+e− collision data collected at center-of-mass energies between 4.612 and 4.699 GeV with the BESIII detector at BEPCII. The branching fraction of Λ+c→nπ+ is measured to be (6.6±1.2stat±0.4syst)×10−4. By taking the upper limit of branching fractions of Λ+c→pπ0 from the Belle experiment, the ratio of branching fractions between Λ+c→nπ+ and Λ+c→pπ0 is calculated to be larger than 7.2 at the 90% confidence level, which disagrees with the current predictions of available phenomenological models. In addition, the branching fractions of the Cabibbo-favored decays Λ+c→Λπ+ and Λ+c→Σ0π+ are measured to be (1.31±0.08stat±0.05syst)×10−2 and (1.22±0.08stat±0.07syst)×10−2, respectively, which are consistent with previous results.
Background: Despite novel therapeutic agents, most multiple myeloma (MM) patients eventually relapse. Two large phase III trials have shown significantly improved response rates (RR) of lenalidomide/dexamethasone compared with placebo/dexamethasone in relapsed MM (RMM) patients. These results have led to the approval of lenalidomide for RMM patients and lenalidomide/dexamethasone has since become a widely accepted second-line treatment. Furthermore, in RMM patients consolidation with high-dose chemotherapy plus autologous stem cell transplantation has been shown to significantly increase progression free survival (PFS) as compared to cyclophosphamide in a phase III trial. The randomized prospective ReLApsE trial is designed to evaluate PFS after lenalidomide/dexamethasone induction, high-dose chemotherapy consolidation plus autologous stem cell transplantation and lenalidomide maintenance compared with the well-established lenalidomide/dexamethasone regimen in RMM patients.
Methods/Design: ReLApsE is a randomized, open, multicenter phase III trial in a planned study population of 282 RMM patients. All patients receive three lenalidomide/dexamethasone cycles and - in absence of available stem cells from earlier harvesting - undergo peripheral blood stem cell mobilization and harvesting. Subsequently, patients in arm A continue on consecutive lenalidomide/dexamethasone cycles, patients in arm B undergo high dose chemotherapy plus autologous stem cell transplantation followed by lenalidomide maintenance until discontinuation criteria are met. Therapeutic response is evaluated after the 3rd (arm A + B) and the 5th lenalidomide/dexamethasone cycle (arm A) or 2 months after autologous stem cell transplantation (arm B) and every 3 months thereafter (arm A + B). After finishing the study treatment, patients are followed up for survival and subsequent myeloma therapies. The expected trial duration is 6.25 years from first patient in to last patient out. The primary endpoint is PFS, secondary endpoints include overall survival (OS), RR, time to best response and the influence of early versus late salvage high dose chemotherapy plus autologous stem cell transplantation on OS.
Discussion: This phase III trial is designed to evaluate whether high dose chemotherapy plus autologous stem cell transplantation and lenalidomide maintenance after lenalidomide/dexamethasone induction improves PFS compared with the well-established continued lenalidomide/dexamethasone regimen in RMM patients. Trial registration: ISRCTN16345835 (date of registration 2010-08-24).
Based on 4.481×108 ψ(3686) events collected with the BESIII detector at BEPCII, the branching fraction of the isospin violating decay ψ(3686)→Σ¯0Λ+c.c. is measured to be (1.60±0.31±0.13 ± 0.58)×10−6, where the first uncertainty is statistical, the second is systematic, and the third is the uncertainty arising from interference with the continuum. This result is significantly smaller than the measurement based on CLEO-c data sets. The decays χcJ→ΛΛ¯ are measured via ψ(3686)→γχcJ, and the branching fractions are determined to be B(χc0→ΛΛ¯)=(3.64±0.10±0.10±0.07)×10−4, B(χc1→ΛΛ¯)=(1.31±0.06±0.06±0.03)×10−4, B(χc2→ΛΛ¯)=(1.91±0.08±0.17±0.04)×10−4, where the third uncertainties are systematic due to the ψ(3686)→γχcJ branching fractions.
The decays 𝜒𝑐𝐽→Σ0¯𝑝𝐾++c.c. (𝐽=0,1,2) are studied via the radiative transition 𝜓(3686)→𝛾𝜒𝑐𝐽 based on a data sample of (448.1±2.9)×106 𝜓(3686) events collected with the BESIII detector. The branching fractions of 𝜒𝑐𝐽→Σ0¯𝑝𝐾++c.c. (𝐽=0,1,2) are measured to be (3.03±0.12±0.15)×10−4, (1.46±0.07±0.07)×10−4, and (0.91±0.06±0.05)×10−4, respectively, where the first uncertainties are statistical and the second are systematic. In addition, no evident structure is found for excited baryon resonances on the two-body subsystems with the limited statistics.
Using a dataset of 6.32 fb−1 of 𝑒+𝑒− annihilation data collected with the BESIII detector at center-of-mass energies between 4178 and 4226 MeV, we have measured the absolute branching fraction of the leptonic decay 𝐷+𝑠→𝜏+𝜈𝜏 via 𝜏+→𝑒+𝜈𝑒¯𝜈𝜏, and find ℬ𝐷+𝑠→𝜏+𝜈𝜏=(5.27±0.10±0.12)×10−2, where the first uncertainty is statistical and the second is systematic. The precision is improved by a factor of 2 compared to the previous best measurement. Combining with 𝑓𝐷+𝑠 from lattice quantum chromodynamics calculations or the |𝑉𝑐𝑠| from the CKMfitter group, we extract |𝑉𝑐𝑠|=0.978±0.009±0.012 and 𝑓𝐷+𝑠=(251.1±2.4±3.0) MeV, respectively. Combining our result with the world averages of ℬ𝐷+𝑠→𝜏+𝜈𝜏 and ℬ𝐷+𝑠→𝜇+𝜈𝜇, we obtain the ratio of the branching fractions ℬ𝐷+𝑠→𝜏+𝜈𝜏/ℬ𝐷+𝑠→𝜇+𝜈𝜇=9.72±0.37, which is consistent with the standard model prediction of lepton flavor universality.
Distinct immune patterns of hepatocellular carcinoma (HCC) may have prognostic implications in the response to transarterial chemoembolization (TACE). Thus, we aimed to exploratively analyze tumor tissue of HCC patients who do or do not respond to TACE, and to identify novel prognostic biomarkers predictive of response to TACE. We retrospectively included 15 HCC patients who had three consecutive TACE between January 2019 and November 2019. Eight patients had a response while seven patients had no response to TACE. All patients had measurable disease according to mRECIST. Corresponding tumor tissue samples were processed for differential expression profiling using NanoString nCounter® PanCancer immune profiling panel. Immune-related pathways were broadly upregulated in TACE responders. The top differentially regulated genes were the upregulated CXCL1 (log2fc 4.98, Benjamini–Hochberg (BH)-p < 0.001), CXCL6 (log2fc 4.43, BH-p = 0.016) and the downregulated MME (log2fc −4.33, BH-p 0.001). CD8/T-regs was highly increased in responders, whereas the relative number of T-regs to tumor-infiltrating lymphocytes (TIL) was highly decreased. We preliminary identified CXCL1 and CXCL6 as candidate genes that might have the potential to serve as therapeutically relevant biomarkers in HCC patients. This might pave the way to improve patient selection for TACE in HCC patients beyond expert consensus.
he absolute branching fraction of Λ→pμ−ν¯μ is reported for the first time based on an e+e− annihilation sample of ten billion J/ψ events collected with the BESIII detector at s√=3.097 GeV. The branching fraction is determined to be B(Λ→pμ−ν¯μ)=[1.48±0.21(stat)±0.08(syst)]×10−4, which is a significant improvement in precision over the previous indirect measurements. Combining this result with the world average of B(Λ→pe−ν¯e), we obtain the ratio, Γ(Λ→pμ−ν¯μ)Γ(Λ→pe−ν¯e), to be 0.178±0.028, which agrees with the standard model prediction assuming lepton flavor universality. The asymmetry of the branching fractions of Λ→pμ−ν¯μ and Λ¯→p¯μ+νμ is also determined, and no evidence for CP violation is found.
Using 448.1 × 106 ψ(3686) events collected with the BESIII detector at BEPCII, we employ a single-baryon tagging technique to make the first observation of ψ(3686) → Ξ(1530)−Ξ¯(1530)+ and Ξ(1530)−Ξ¯+ decays with a statistical significance of more than 10σ and 5.0σ, respectively. The branching fractions are measured to be B[ψ(3686)→Ξ(1530)−Ξ¯(1530)+] = (11.45 ± 0.40 ± 0.59) × 10−5 and B[ψ(3686)→Ξ(1530)−Ξ¯+] = (0.70 ± 0.11 ± 0.04) × 10−5. The angular distribution parameter for ψ(3686) → Ξ(1530)−Ξ¯(1530)+ is determined to be α = 0.40 ± 0.24 ± 0.06, which agrees with the theoretical predictions within 1σ. The first uncertainties are statistical, and the second systematic.
The Born cross section for the process e+e−→pp¯ is measured using the initial state radiation technique with an undetected photon. This analysis is based on datasets corresponding to an integrated luminosity of 7.5 fb−1, collected with the BESIII detector at the BEPCII collider at center of mass energies between 3.773 and 4.600 GeV. The Born cross section for the process e+e−→pp¯ and the proton effective form factor are determined in the pp¯ invariant mass range between 2.0 and 3.8 GeV/c2 divided into 30 intervals. The proton form factor ratio (|GE|/|GM|) is measured in 3 intervals of the pp¯ invariant mass between 2.0 and 3.0 GeV/c2.
We report on a comparison of two possible Λ+c spin hypotheses, J=12 and 32, via the process e+e−→Λ+cΛ¯−c, using the angular distributions of Λ+c decays into pK0S, Λπ+, Σ0π+, and Σ+π0. The data were recorded at s√=4.6 GeV with the BESIII detector and correspond to an integrated luminosity of 587 pb−1. The Λ+c spin is determined to be J=12, with this value favored over the 32 hypothesis with a significance corresponding to more than 6 Gaussian standard deviations.
Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents in clinical trials. We retrospectively compared bortezomib (BTZ; n = 138) or LEN (n = 183) MT from two subsequent GMMG phase III trials. All patients received three cycles of BTZ-based triplet induction and post-ASCT MT. BTZ MT (1.3 mg/m2 i.v.) was administered every 2 weeks for 2 years. LEN MT included two consolidation cycles (25 mg p.o., days 1–21 of 28 day cycles) followed by 10–15 mg/day for 2 years. The BTZ cohort more frequently received tandem ASCT (91% vs. 33%) due to different tandem ASCT strategies. In the LEN and BTZ cohort, 43% and 46% of patients completed 2 years of MT as intended (p = 0.57). Progression-free survival (PFS; HR = 0.83, p = 0.18) and overall survival (OS; HR = 0.70, p = 0.15) did not differ significantly with LEN vs. BTZ MT. Patients with <nCR after first ASCT were assigned tandem ASCT in both trials. In patients with <nCR and tandem ASCT (LEN: n = 54 vs. BTZ: n = 84), LEN MT significantly improved PFS (HR = 0.61, p = 0.04) but not OS (HR = 0.46, p = 0.09). In conclusion, the significant PFS benefit after eliminating the impact of different tandem ASCT rates supports the current standard of LEN MT after ASCT.
By analyzing 4.48×108 ψ(3686) events collected with the BESIII detector, we observe the decays χcJ→nK0SΛ¯+c.c. (J=0, 1, 2) for the first time, via the radiative transition ψ(3686)→γχcJ. The branching fractions are determined to be (6.67±0.26stat±0.41syst)×10−4, (1.71±0.12stat±0.12syst)×10−4, and (3.66±0.17stat±0.23syst)×10−4 for J=0, 1, and 2, respectively.
Using a data sample of ψ(3770) events collected with the BESIII detector at BEPCII corresponding to an integrated luminosity of 2.9 fb−1, we report a measurement of Λ spin polarization in e+e−→ΛΛ¯ at s√=3.773 GeV. The significance of polarization is found to be 2σ including the systematic uncertainty, which implies a zero phase between the transition amplitudes of the ΛΛ¯ helicity states. This phase can be interpreted in terms of psionic form factors, and is determined to be ΔΦΨ = ΦΨE−ΦΨM = (71+66−46 ± 5)∘. Similarly, the ratio between the form factors is found to be Rψ = |GΨE/GΨM| = 0.48+0.12−0.07 ± 0.04. The first uncertainties are statistical and the second systematic.
Cross sections of the process 𝑒+𝑒−→𝜋0𝜋0𝐽/𝜓 at center-of-mass energies between 3.808 and 4.600 GeV are measured with high precision by using 12.4 fb−1 of data samples collected with the BESIII detector operating at the BEPCII collider facility. A fit to the measured energy-dependent cross sections confirms the existence of the charmoniumlike state 𝑌(4220). The mass and width of the 𝑌(4220) are determined to be (4220.4±2.4±2.3) MeV/𝑐2 and (46.2±4.7±2.1) MeV, respectively, where the first uncertainties are statistical and the second systematic. The mass and width are consistent with those measured in the process 𝑒+𝑒−→𝜋+𝜋−𝐽/𝜓. The neutral charmonium-like state 𝑍𝑐(3900)0 is observed prominently in the 𝜋0𝐽/𝜓 invariant-mass spectrum, and, for the first time, an amplitude analysis is performed to study its properties. The spin-parity of 𝑍𝑐(3900)0 is determined to be 𝐽𝑃=1+, and the pole position is (3893.1±2.2±3.0)−𝑖(22.2±2.6±7.0) MeV/𝑐2, which is consistent with previous studies of electrically charged 𝑍𝑐(3900)±. In addition, cross sections of 𝑒+𝑒− → 𝜋0𝑍𝑐(3900)0 → 𝜋0𝜋0𝐽/𝜓 are extracted, and the corresponding line shape is found to agree with that of the 𝑌(4220).