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The article examines the role of the "natural law of nations" in Vico's philosophy of culture. The focal point of this inquiry is the notion of 'barbarism' in the New Science. While Vico's influential conception of the 'barbarism of reflection' has attracted a lot of attention, the multiplicity of tropes of barbarism in the New Science has not been sufficiently recognized. The article argues that while Vico takes civil law, the Roman ius gentium, as a model for his conception of culture, the trope of the warring barbarian figures prominently in key moments of his philosophy of history (e. g. in transitional moments between two historical ages) when issues of modern international law (asylum, declaration of war, piracy) are at stake.
Men and women differ substantially regarding height, weight, and body fat. Interestingly, previous work detecting genetic effects for waist-to-hip ratio, to assess body fat distribution, has found that many of these showed sex-differences. However, systematic searches for sex-differences in genetic effects have not yet been conducted. Therefore, we undertook a genome-wide search for sexually dimorphic genetic effects for anthropometric traits including 133,723 individuals in a large meta-analysis and followed promising variants in further 137,052 individuals, including a total of 94 studies. We identified seven loci with significant sex-difference including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were significant in women, but not in men. Of interest is that sex-difference was only observed for waist phenotypes, but not for height or body-mass-index. We found no evidence for sex-differences with opposite effect direction for men and women. The PPARG locus is of specific interest due to its link to diabetes genetics and therapy. Our findings demonstrate the importance of investigating sex differences, which may lead to a better understanding of disease mechanisms with a potential relevance to treatment options.