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Abdulhamid, Muhammad Ibrahim ; Aboona, Bassam ; Adam, Jaroslav ; Adams, Joseph ; Agakishiev, Geydar ; Aggarwal, Ishu ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Aitbaev, Alisher ; Alekseev, Igor ; Anderson, Derek ; Aparin, Alexey ; Aslam, Sameer ; Atchison, Joseph ; Averichev, Georgy ; Bairathi, Vipul ; Baker, William ; Ball Cap, Jonathan Gonzalo ; Barish, Kenneth ; Bhagat, Pratibha ; Bhasin, Anju ; Bhatta, Somadutta ; Bordyuzhin, Igor G. ; Brandenburg, James ; Brandin, Andrei ; Cai, Xiang-Zhou ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel ; Češka, Jakub ; Chakaberia, Irakli ; Chan, Brian ; Chang, Zilong ; Chatterjee, Arghya ; Chen, Ding ; Chen, J. ; Chen, J.H. ; Chen, Zhenyu ; Cheng, Jianping ; Cheng, Yunshan ; Choudhury, Subikash ; Christie, Bill ; Christie, William ; Chu, Xiaoxuan ; Crawford, Henry J. ; Dale-Gau, Gabriel ; Das, Ayanabha ; Daugherity, Michael ; Dedovich, Tatiana ; Deppner, Ingo Martin ; Derevschikov, Anatoly ; Dhamija, Arushi ; Di Carlo, Launa ; 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Zyzak, Maksym
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
Adam, Jaroslav ; Adamczyk, Leszek ; Adams, Joseph R. ; Adkins, J. Kevin ; Agakishiev, Geydar ; Aggarwal, Madan Mohan ; Ahammed, Zubayer ; Alekseev, Igor G. ; Anderson, Derek M. ; Aoyama, Ryo ; Aparin, Alexey ; Arkhipkin, Dmitry A. ; Aschenauer, Elke Caroline ; Ashraf, Muhammad Usman ; Atetalla, Fareha ; Attri, Anjali ; Averichev, Georgy S. ; Bairathi, Vipul ; Barish, Kenneth ; Bassill, Aaron J. ; Behera, Arabinda ; Bellwied, Rene ; Bhasin, Anju ; Bhati, Ashok Kumar ; Bielčík, Jaroslav ; Bielčíková, Jana ; Bland, Leslie C. ; Bordyuzhin, Igor G. ; Brandenburg, James D. ; Brandin, Andrei V. ; Bryslawskyj, Jason ; Bunzarov, Ivan ; Butterworth, Joseph ; Caines, Helen Louise ; Calderón de la Barca Sánchez, Manuel ; Cebra, Daniel A. ; Chakaberia, Irakli ; Chaloupka, Petr ; Chan, Brian ; Chang, Feng-Han ; Chang, Zilong ; Chankova-Bunzarova, Nedialka ; Chatterjee, Arghya ; Chattopadhyay, Subhasis ; Chen, Jinhui ; Chen, Xiaolong ; Cheng, Jianping ; Cherney, Michael Gerard ; Christie, William ; Crawford, Henry J. ; Csanád, Máté ; Das, Supriya ; Dedovič, Tatiana G. ; Deppner, Ingo Martin ; Derevschikov, Anatoly A. ; Didenko, Lidia ; Dilks, Christopher ; Dong, Xin ; Drachenberg, James Lucus ; Dunlop, James C. ; Edmonds, Terrence ; Elsey, Nicholas ; Engelage, Jon M. ; Eppley, Geary Wareham ; Esha, Roli ; Esumi, ShinIchi ; Evdokimov, Olga Y. ; Ewigleben, Justin ; Eyser, Kjeld Oleg ; Fatemi, Renee H. ; Fazio, Salvatore ; Federič, Pavol ; Fedorišin, Jan ; Feng, Yicheng ; Filip, Peter ; Finch, Evan ; Fisyak, Yuri V. ; Fulek, Łukasz ; Gagliardi, Carl A. ; Galatyuk, Tetyana ; Geurts, Frank ; Gibson, Adam ; Gopal, Krishan ; Grosnick, David P. ; Gupta, Anik ; Guryn, Włodzimierz ; Hamad, Ayman ; Hamed, Ahmed M. ; Harris, John W. ; He, Liang ; Heppelmann, Samuel ; Heppelmann, Steven Francis ; Herrmann, Norbert ; Holub, Lukáš ; Hong, Yifan ; Horvat, Stephen P. ; Huang, Bingchu ; Huang, Huan Zhong ; Huang, Shengli ; Huang, Te-Chuan ; Huang, Xinjie ; Humanic, Thomas J. ; Huo, Peng ; Igo, George J. ; Jacobs, William W. ; Jena, Chitrasen ; Jentsch, Alexander ; Ji, Yuanjing ; Jia, Jiangyong ; Jiang, Kun ; Jowzaee, Sedigheh ; Ju, Xin-Yue ; Judd, Eleanor G. ; Kabana, Sonia ; Kagamaster, Skipper ; Kalinkin, Dmitry ; Kang, Kejun ; Kapukchyan, David ; Kauder, Kolja ; Ke, Hongwei ; Keane, Declan ; Kechechyan, Armen ; Kelsey, Matthew ; Khyzhniak, Yevheniia V. ; Kikoła, Daniel P. ; Kim, Chong ; Kinghorn, Todd Adler ; Kisel, Ivan ; Kisiel, Adam Ryszard ; Kocan, Michal ; Kočenda, L. M. ; Kosarzewski, Leszek Krzysztof ; Kramárik, Lukáš ; Kravtsov, Peter ; Krueger, Keith William ; Kulathunga Mudiyanselage, Nalinda ; Kumar, Lokesh ; Kunnawalkam Elayavalli, Raghav ; Kwasizur, Joseph H. ; Lacey, Roy Alphanso ; Landgraf, Jeffery M. ; Lauret, Jerome ; Lebedev, Alexei ; Lednicky, Richard ; Lee, Jeong-Hun ; Li, Cheng ; Li, Wei ; Li, Wei ; Li, Xin ; Li, Yuanjing ; Liang, Yue ; Licenik, Robert ; Lin, Ting ; Lipiec, Andrzej ; Lisa, Michael A. ; Liu, Feng ; Liu, Huanzhao ; Liu, Peifeng ; Liu, Peng ; Liu, Tong ; Liu, Xiaoyu ; Liu, Y. ; Liu, Zhen ; Ljubicic, Tonko A. ; Llope, William Joseph ; Lomnitz, Michael ; Longacre, Ronald S. ; Luo, Siwei ; Luo, Xiaofeng ; Ma, Guo-Liang ; Ma, Long ; Ma, Rongrong ; Ma, Yu-Gang ; Magdy Abdelwahab Abdelrahman, Niseem ; Majka, Richard Daniel ; Mallick, Dukhishyam ; Margetis, Spyridon ; Markert, Christina ; Matis, Howard S. ; Matonoha, Oliver ; Mazer, Joel Anthony ; Meehan, Kathryn ; Mei, Jincheng ; Minaev, Nikolai G. ; Mioduszewski, Saskia ; Mishra, Debadeepti ; Mohanty, Bedangadas ; Mouli, Mriganka Mouli ; Mooney, Isaac A. ; Moravcova, Zuzana ; Morozov, Dmitry A. ; Nasim, Md. ; Nayak, Kishora ; Nelson, John M. ; Nemes, Daniel B. ; Nie, Maowu ; Nigmatkulov, Grigory A. ; Niida, Takafumi ; Nogach, Larisa V. ; Nonaka, Toshihiro ; Odyniec, Grazyna Janina ; Ogawa, Akio ; Oh, Kunsu ; Oh, Saehanseul ; Okorokov, Vitaly A. ; Page, Brian S. ; Pak, Robert ; Panebratsev, Yuri ; Pawlik, Bogdan ; Pawłowska, Diana ; Pei, Hua ; Perkins, Chris ; Pintér, Roland Laszlo ; Pluta, Jan Marian ; Porter, Jeffrey Brent ; Posik, Matthew ; Pruthi, Navneet Kumar ; Przybycien, Mariusz ; Putschke, Jörn H. ; Quintero, Amilkar ; Radhakrishnan, Sooraj Krishnan ; Ramachandran, Suvarna ; Ray, Robert L. ; Reed, Rosi Jan ; Ritter, Hans Georg ; Roberts, Jabus B. ; Rogačevskij, Oleg V. ; Romero, Juan L. ; Ruan, Lijuan ; Rusnak, Jan ; Rusnakova, Olga ; Sahoo, Nihar Ranjan ; Sahu, Pradip Kumar ; Salur, Sevil ; Sandweiss, Jack H. ; Schambach, Joachim ; Schmidke, William B. ; Schmitz, Norbert ; Schweid, Benjamin R. ; Seck, Florian ; Seger, Janet Elizabeth ; Sergeeva, Maria ; Seto, Richard ; Seyboth, Peter ; Shah, Neha ; Shahaliev, Ehtiram ; Shanmuganathan, Prashanth V. ; Shao, Ming ; Shen, Fuwang ; Shen, Wenqing ; Shi, Shusu ; Shou, Qiye ; Sichtermann, Ernst P. ; Siejka, Sebastian ; Sikora, Rafał ; Šimko, Miroslav ; Singh, Jagbir ; Singha, Subhash ; Smirnov, Dmitri V. ; Smirnov, Nikolai ; Solyst, William ; Sorensen, Paul Richard ; Spinka, Harold. M. ; Srivastava, Brijesh Kumar ; Stanislaus, T. D. Shirvel ; Stefaniak, Maria ; Stewart, David J. ; Strichanov, Michail Nikolaevič ; Stringfellow, Blair ; Suaide, Alexandre Alarcon do Passo ; Sugiura, Tetsuro ; Šumbera, Michal ; Summa, Branden ; Sun, Xiangming ; Sun, Yongjie ; Sun, Yuliang ; Surrow, Bernd ; Svirida, Dmitry N. ; Szymański, Paweł ; Tang, Aihong ; Tang, Zebo ; Taranenko, Arkadiy ; Tarnowsky, Terence J. ; Thomas, James H. ; Timmins, Anthony Robert ; Tlusty, David ; Todoroki, Takahito ; Tokarev, Mikhail V. ; Tomkiel, Catherine A. ; Trentalange, Stephen ; Tribble, Robert E. ; Tribedy, Prithwish ; Tripathy, Srikanta Kumar ; Tsai, Oleg D. ; Tu, Biao ; Tu, Zhoudunming ; Ullrich, Thomas ; Underwood, David G. ; Upsal, Isaac ; Van Buren, Gene ; Vanek, Jan ; Vasiliev, Alexander Nikolaevich ; Vassiliev, Iouri ; Videbæk, Flemming ; Vokal, Stanislav ; Voloshin, Sergei ; Wang, Fuqiang ; Wang, Gang ; Wang, Pengfei ; Wang, Yi ; Wang, Yaping ; Webb, Jason C. ; Wen, Liwen ; Westfall, Gary D. ; Wieman, Howard ; Wissink, Scott W. ; Witt, Richard ; Wu, Yang ; Xiao, Zhigang ; Xie, Guannan ; Xie, Wei ; Xu, Haojie ; Xu, Nu ; Xu, Qinghua ; Xu, Yi-Fei ; Xu, Zhangbu ; Yang, Chi ; Yang, Qian ; Yang, Shuai ; Yang, Yi ; Yang, Zhenzhen ; Ye, Zaochen ; Ye, Zhenyu ; Yi, Li ; Yip, Kin ; Yoo, In-Kwon ; Zbroszczyk, Hanna Paulina ; Zha, Wangmei ; Zhang, Dingwei ; Zhang, Liang ; Zhang, Shenghui ; Zhang, Song ; Zhang, Xiaoping ; Zhang, Yifei ; Zhang, Zhengqiao ; Zhao, Jie ; Zhong, Chen ; Zhou, Chensheng ; Zhu, Xianglei ; Zhu, Zhanwen ; Zurek, Marian ; Zyzak, Maksym
J/ψ suppression has long been considered a sensitive signature of the formation of the Quark-Gluon Plasma (QGP) in relativistic heavy-ion collisions. In this letter, we present the first measurement of inclusive J/ψ production at mid-rapidity through the dimuon decay channel in Au+Au collisions at √sNN = 200 GeV with the STAR experiment. These measurements became possible after the installation of the Muon Telescope Detector was completed in 2014. The J/ψ yields are measured in a wide transverse momentum (pT) range of 0.15 GeV/c to 12 GeV/c from central to peripheral collisions. They extend the kinematic reach of previous measurements at RHIC with improved precision. In the 0-10% most central collisions, the J/ψ yield is suppressed by a factor of approximately 3 for pT > 5 GeV/c relative to that in p + p collisions scaled by the number of binary nucleon-nucleon collisions. The J/ψ nuclear modification factor displays little dependence on pT in all centrality bins. Model calculations can qualitatively describe the data, providing further evidence for the color-screening effect experienced by J/ψ mesons in the QGP.
We identify strong cross-border institutions as a driver for the globalization of in-novation. Using 67 million patents from over 100 patent offices, we introduce novel measures of innovation diffusion and collaboration. Exploiting staggered bilateral in-vestment treaties as shocks to cross-border property rights and contract enforcement, we show that signatory countries increase technology adoption and sourcing from each other. They also increase R&D collaborations. These interactions result in techno-logical convergence. The effects are particularly strong for process innovation, and for countries that are technological laggards or have weak domestic institutions. Increased inter-firm rather than intra-firm foreign investment is the key channel.
Théry, Clotilde ; Witwer, Kenneth W. ; Aikawa, Elena ; Alcaraz, Maria Jose ; Anderson, Johnathon D. ; Andriantsitohaina, Ramaroson ; Antoniou, Anna ; Arab, Tanina ; Archer, Fabienne ; Atkin-Smith, Georgia K. ; Ayre, D. Craig ; Bach, Jean-Marie ; Bachurski, Daniel ; Baharvand, Hossein ; Balaj, Leonora ; Baldacchino, Shawn ; Bauer, Natalie N. ; Baxter, Amy A. ; Bebawy, Mary ; Beckham, Carla ; Zavec, Apolonija Bedina ; Benmoussa, Abderrahim ; Berardi, Anna C. ; Bergese, Paolo ; Bielska, Ewa ; Blenkiron, Cherie ; Bobis-Wozowicz, Sylwia ; Boilard, Eric ; Boireau, Wilfrid ; Bongiovanni, Antonella ; Borràs, Francesc E. ; Bosch, Steffi ; Boulanger, Chantal M. ; Breakefield, Xandra ; Breglio, Andrew M. ; Brennan, Meadhbh Aín ; Brigstock, David R. ; Brisson, Alain ; Broekman, Marike L. D. ; Bromberg, Jacqueline F. ; Bryl-Gorecka, Paulina ; Buch, Shilpa ; Buck, Amy H. ; Burger, Dylan ; Busatto, Sara ; Buschmann, Dominik ; Bussolati, Benedetta ; Buzás, Edit I. ; Byrd, James Bryan ; Camussi, Giovanni ; Carter, David R. F. ; Caruso, Sarah ; Chamley, Lawrence W. ; Chang, Yu-Ting ; Chen, Chihchen ; Chen, Shuai ; Cheng, Lesley ; Chin, Andrew R. ; Clayton, Aled ; Clerici, Stefano P. ; Cocks, Alex ; Cocucci, Emanuele ; Coffey, Robert J. ; Cordeiro-da-Silva, Anabela ; Couch, Yvonne ; Coumans, Frank A. W. ; Coyle, Beth ; Crescitelli, Rossella ; Criado, Miria Ferreira ; D’Souza-Schorey, Crislyn ; Das, Saumya ; Chaudhuri, Amrita Datta ; de-Candia, Paola ; De Santana, Eliezer F. ; De Wever, Olivier ; del Portillo, Hernando A. ; Demaret, Tanguy ; Deville, Sarah ; Devitt, Andrew ; Dhondt, Bert ; Di Vizio, Dolores ; Dieterich, Lothar C. ; Dolo, Vincenza ; Dominguez Rubio, Ana Paula ; Dominici, Massimo ; Dourado, Mauricio R. ; Driedonks, Tom A. P. ; Duarte, Filipe V. ; Duncan, Heather M. ; Eichenberger, Ramon Marc ; Ekström, Karin ; El Andaloussi, Samir ; Elie-Caille, Celine ; Erdbrügger, Uta ; Falcón-Pérez, Juan M. ; Fatima, Farah ; Fish, Jason E. ; Flores-Bellver, Miguel ; Försönits, András ; Frelet-Barrand, Annie ; Fricke, Fabia ; Fuhrmann, Gregor ; Gabrielsson, Susanne ; Gámez-Valero, Ana ; Gardiner, Chris ; Gärtner, Kathrin ; Gaudin, Raphael ; Gho, Yong Song ; Giebel, Bernd ; Gilbert, Caroline ; Gimona, Mario ; Giusti, Ilaria ; Goberdhan, Deborah C. I. ; Görgens, André ; Gorski, Sharon M. ; Greening, David W. ; Groß, Julia Christina ; Gualerzi, Alice ; Gupta, Gopal N. ; Gustafson, Dakota ; Handberg, Aase ; Haraszti, Réka Ágnes ; Harrison, Paul ; Hegyesi, Hargita ; Hendrix, An ; Hill, Andrew F. ; Hochberg, Fred H. ; Hoffmann, Karl F. ; Holder, Beth ; Holthofer, Harry ; Hosseinkhani, Baharak ; Hu, Guoku ; Huang, Yiyao ; Huber, Veronica ; Hunt, Stuart ; Ibrahim, Ahmed Gamal-Eldin ; Ikezu, Tsuneya ; Inal, Jameel M. ; Isin, Mustafa ; Ivanova, Alena ; Jackson, Hannah K. ; Jacobsen, Soren ; Jay, Steven M. ; Jayachandran, Muthuvel ; Jenster, Guido ; Jiang, Lanzhou ; Johnson, Suzanne M. ; Jones, Jennifer C. ; Jong, Ambrose ; Jovanovic-Talisman, Tijana ; Jung, Stephanie ; Kalluri, Raghu ; Kano, Shin-ichi ; Kaur, Sukhbir ; Kawamura, Yumi ; Keller, Evan T. ; Khamari, Delaram ; Khomyakova, Elena ; Khvorova, Anastasia ; Kierulf, Peter ; Kim, Kwang Pyo ; Kislinger, Thomas ; Klingeborn, Mikael ; Klinke, David J. ; Kornek, Miroslaw ; Kosanović, Maja M. ; Kovács, Árpád Ferenc ; Krämer-Albers, Eva-Maria ; Krasemann, Susanne ; Krause, Mirja ; Kurochkin, Igor V. ; Kusuma, Gina D. ; Kuypers, Sören ; Laitinen, Saara ; Langevin, Scott M. ; Languino, Lucia R. ; Lannigan, Joanne ; Lässer, Cecilia ; Laurent, Louise C. ; Lavieu, Gregory ; Lázaro-Ibáñez, Elisa ; Le Lay, Soazig ; Lee, Myung-Shin ; Lee, Yi Xin Fiona ; Lemos, Debora S. ; Lenassi, Metka ; Leszczynska, Aleksandra ; Li, Isaac T. S. ; Liao, Ke ; Libregts, Sten F. ; Ligeti, Erzsebet ; Lim, Rebecca ; Lim, Sai Kiang ; Linē, Aija ; Linnemannstöns, Karen ; Llorente, Alicia ; Lombard, Catherine Ann ; Lorenowicz, Magdalena J. ; Lörincz, Ákos M. ; Lötvall, Jan ; Lovett, Jason ; Lowry, Michelle C. ; Loyer, Xavier ; Lu, Quan ; Lukomska, Barbara ; Lunavat, Taral Rameshchand ; Maas, Sybren L. N. ; Malhi, Harmeet ; Marcilla, Antonio ; Mariani, Jacopo ; Mariscal, Javier ; Martens-Uzunova, Elena S. ; Martin-Jaular, Lorena ; Martinez, M. Carmen ; Martins, Vilma Regina ; Mathieu, Mathilde ; Mathivanan, Suresh ; Maugeri, Marco ; McGinnis, Lynda K. ; McVey, Mark J. ; Meckes, David G. ; Meehan, Katie ; Mertens, Inge ; Minciacchi, Valentina R. ; Möller, Andreas ; Møller Jørgensen, Malene ; Morales-Kastresana, Aizea ; Morhayim, Jess ; Mullier, François ; Muraca, Maurizio ; Musante, Luca ; Mussack, Veronika ; Muth, Dillon C. ; Myburgh, Kathryn H. ; Najrana, Tanbir ; Nawaz, Muhammad ; Nazarenko, Irina ; Nejsum, Peter ; Neri, Christian ; Neri, Tommaso ; Nieuwland, Rienk ; Nimrichter, Leonardo ; Nolan, John P. ; Nolte-’t Hoen, Esther N. M. ; Hooten, Nicole Noren ; O’Driscoll, Lorraine ; O’Grady, Tina ; O’Loghlen, Ana ; Ochiya, Takahiro ; Olivier, Martin ; Ortiz, Alberto ; Ortiz, Luis A. ; Osteikoetxea, Xabier ; Østergaard, Ole ; Ostrowski, Matias ; Park, Jaesung ; Pegtel, Dirk Michiel ; Peinado, Hector ; Perut, Francesca ; Pfaffl, Michael ; Phinney, Donald G. ; Pieters, Bartijn C. H. ; Pink, Ryan Charles ; Pisetsky, David S. ; Pogge von Strandmann, Elke ; Polakovicova, Iva ; Poon, Ivan K. H. ; Powell, Bonita H. ; Prada, Ilaria ; Pulliam, Lynn ; Quesenberry, Peter ; Radeghieri, Annalisa ; Raffai, Robert L. ; Raimondo, Stefania ; Rak, Janusz ; Ramirez, Marcel I. ; Raposo, Graça ; Rayyan, Morsi S. ; Regev-Rudzki, Neta ; Ricklefs, Franz Lennard ; Robbins, Paul D. ; Roberts, David D. ; Rodrigues, Silvia C. ; Rohde, Eva ; Rome, Sophie ; Rouschop, Kasper M. ; Rughetti, Aurelia ; Russell, Ashley E. ; Saá, Paula ; Sahoo, Susmita ; Salas-Huenuleo, Edison ; Sánchez, Catherine ; Saugstad, Julie A. ; Saul, Meike J. ; Schiffelers, Raymond M. ; Schneider, Raphael ; Schøyen, Tine Hiorth ; Scott, Aaron ; Shahaj, Eriomina ; Sharma, Shivani ; Shatnyeva, Olga ; Shekari, Faezeh ; Shelke, Ganesh Vilas ; Shetty, Ashok K. ; Shiba, Kiyotaka ; Siljander, Pia R.-M. ; Silva, Andreia M. ; Skowronek, Agata ; Snyder, Orman L. ; Soares, Rodrigo Pedro ; Sódar, Barbara W. ; Soekmadji, Carolina ; Sotillo, Javier ; Stahl, Philip D. ; Stoorvogel, Willem ; Stott, Shannon L. ; Strasser, Erwin F. ; Swift, Simon ; Tahara, Hidetoshi ; Tewari, Muneesh ; Timms, Kate ; Tiwari, Swasti ; Tixeira, Rochelle ; Tkach, Mercedes ; Toh, Wei Seong ; Tomasini, Richard ; Torrecilhas, Ana Claudia ; Tosar, Juan Pablo ; Toxavidis, Vasilis ; Urbanelli, Lorena ; Vader, Pieter ; Balkom, Bastiaan Wilhelmus Maria van ; Grein, Susanne G. van der ; Van Deun, Jan ; Herwijnen, Martijn J. C. van ; Van Keuren-Jensen, Kendall R. ; Niel, Guillaume van ; Royen, Martin E. van ; Wijnen, Andre J. van ; Vasconcelos, M. Helena ; Vechetti, Ivan J. ; Veit, Tiago D. ; Vella, Laura J. ; Velot, Émilie ; Verweij, Frederik ; Vestad, Beate ; Viñas, Jose Luis ; Visnovitz, Tamás ; Vukman, Krisztina V. ; Wahlgren, Jessica ; Watson, Dionysios C. ; Wauben, Marca H. M. ; Weaver, Alissa ; Webber, Jason P. ; Weber, Viktoria ; Wehman, Ann M. ; Weiss, Daniel J. ; Welsh, Joshua A. ; Wendt, Sebastian ; Wheelock, Åsa M. ; Wiener, Zoltán ; Witte, Leonie ; Wolfram, Joy ; Xagorari, Angeliki ; Xander, Patricia ; Xu, Jing ; Yan, Xiaomei ; Yáñez-Mó, María ; Yin, Hang ; Yuana, Yuana ; Zappulli, Valentina ; Zarubova, Jana ; Žėkas, Vytautas ; Zhang, Jian-ye ; Zhao, Zezhou ; Zheng, Lei ; Zheutlin, Alexander R. ; Zickler, Antje Maria ; Zimmermann, Pascale ; Zivkovic, Angela M. ; Zocco, Davide ; Zuba-Surma, Ewa K.
The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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