Refine
Document Type
- Article (5)
Language
- Portuguese (3)
- German (1)
- English (1)
Has Fulltext
- yes (5)
Keywords
- Kommunikation (2)
- BI1361849 (1)
- CV9202 (1)
- Clinical trial (1)
- Gesellschaft (1)
- Hypofractionated radiotherapy (1)
- Immunomonitoring (1)
- Kommunikationsgemeinschaft (1)
- Konstruktivismus <Soziologie> (1)
- Kontrastive Linguistik (1)
Institute
- Medizin (1)
Im FFH-Gebiet „Lausiger Teiche und Ausreißer-Teich östlich Bad Schmiedeberg“ wurde das in Sachsen-Anhalt als verschollen geltende Torfmoos Sphagnum obtusum (Warnst.) im Rahmen der FFH-Erfassung 2006 gefunden und bestimmt. Sphagnum obtusum ist die kräftigste Art der Sektion cuspidata der Gattung Sphagnum, vom ebenfalls kräftigen Sphagnum flexuosum nur durch winzige Poren in den Hyalinzellen der Astblätter unterschieden. Die Art besiedelt mesotrophe bis eutrophe Sümpfe, oft teilweise untergetaucht in Tümpeln oder an Fluss- und Seeufern. An den zwei aktuellen Fundstellen in Sachsen wächst die Art in Teichverlandungsmooren – genau wie am neuen Fundort in Sachsen-Anhalt.
Com base em um corpus de quatro gêneros textuais – entrevistas orais e escritas, artigos jornalísticos e livros de não-ficção – o artigo focaliza o modo como o conceito 'sociedade' é abordado metaforicamente em discursos brasileiros e alemães atuais. Os resultados mostram que certos esquemas imagéticos são mais misturados e dinâmicos no corpus alemão em oposição ao corpus brasileiro, onde a percepção da própria sociedade tende a ser mais estática. Com relação a metáforas conceituais, destacam-se as metáforas negócio, edifício, jogo e observação como mais frequentes no corpus alemão, ao passo que no corpus brasileiro o uso das metáforas personificação, palco, flora, família e guerra é mais frequente. Acrescenta-se também uma microanálise que leva em consideração o contexto e as intenções dos locutores que revelam as funções comunicativas ligadas à preferência de certas metáforas.
This article makes a comparative study of the views on "love" of Brasilian and German students. It turned out that the love affairs between German students were, strongly determined by the romantic ideal of love, whereas Brasilian students have a more passionate ideal of love.
The article presents an analysis of different speech styles used by participants of the German speech community in contrast to the Brazilian one, based on examples of interviews made in both cultures. After the illustration of the different language uses, the article’s focus will be on the communicative functions the styles in each community. So, we find the phatic, poetic and expressive function more dominant in the Brazilian speech, whereas the use of the referential and the metalinguistic function seem to be more common in the speech of the German respondents. It is therefore possible to establish the dichotomy between the actor and the spectator in a metaphorical sense to summarize these contrasting functions. Finally, the fact in which these results can in part be explicated by their embedding in different cultural and historical backgrounds, emphasizing the Brazilian speech community as a more heterogenous and baroque, compared with the German one which tends to be more homogenous and (self)-observing will be shown.
Background: Preclinical studies demonstrate synergism between cancer immunotherapy and local radiation, enhancing anti-tumor effects and promoting immune responses. BI1361849 (CV9202) is an active cancer immunotherapeutic comprising protamine-formulated, sequence-optimized mRNA encoding six non-small cell lung cancer (NSCLC)-associated antigens (NY-ESO-1, MAGE-C1, MAGE-C2, survivin, 5T4, and MUC-1), intended to induce targeted immune responses.
Methods: We describe a phase Ib clinical trial evaluating treatment with BI1361849 combined with local radiation in 26 stage IV NSCLC patients with partial response (PR)/stable disease (SD) after standard first-line therapy. Patients were stratified into three strata (1: non-squamous NSCLC, no epidermal growth factor receptor (EGFR) mutation, PR/SD after ≥4 cycles of platinum- and pemetrexed-based treatment [n = 16]; 2: squamous NSCLC, PR/SD after ≥4 cycles of platinum-based and non-platinum compound treatment [n = 8]; 3: non-squamous NSCLC, EGFR mutation, PR/SD after ≥3 and ≤ 6 months EGFR-tyrosine kinase inhibitor (TKI) treatment [n = 2]). Patients received intradermal BI1361849, local radiation (4 × 5 Gy), then BI1361849 until disease progression. Strata 1 and 3 also had maintenance pemetrexed or continued EGFR-TKI therapy, respectively. The primary endpoint was evaluation of safety; secondary objectives included assessment of clinical efficacy (every 6 weeks during treatment) and of immune response (on Days 1 [baseline], 19 and 61).
Results: Study treatment was well tolerated; injection site reactions and flu-like symptoms were the most common BI1361849-related adverse events. Three patients had grade 3 BI1361849-related adverse events (fatigue, pyrexia); there was one grade 3 radiation-related event (dysphagia). In comparison to baseline, immunomonitoring revealed increased BI1361849 antigen-specific immune responses in the majority of patients (84%), whereby antigen-specific antibody levels were increased in 80% and functional T cells in 40% of patients, and involvement of multiple antigen specificities was evident in 52% of patients. One patient had a partial response in combination with pemetrexed maintenance, and 46.2% achieved stable disease as best overall response. Best overall response was SD in 57.7% for target lesions.
Conclusion: The results support further investigation of mRNA-based immunotherapy in NSCLC including combinations with immune checkpoint inhibitors.
Trial registration: ClinicalTrials.gov identifier: NCT01915524.