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Accurate spectroscopy of highly-charged high-Z ions in a storage ring is demonstrated to be feasible by the use of specially adapted crystal optics. The method has been applied for the measurement of the 1s Lamb shift in hydrogen-like gold (Au+78) in a storage ring through spectroscopy of the Lyman x-rays. This measurement represents the first result obtained for a high-Z element using high-resolution wavelength-dispersive spectroscopy in the hard x-ray regime, paving the way for sensitivity to higher- order QED effects.
Die Säuger
(1993)
Die stark strukturierte Niederungslandschaft des Drömlings bietet über 40 Säugetierarten Lebensraum. In der Roten Liste der Säugetiere des Landes Sachsen-Anhalt (Stand: Mai 1992) sind 21 der bisher festgestellten Arten als gefährdet. stark gefährdet bzw. vom Aussterben bedroht geführt. Charakteristisch für das Gebiet ist das Vorkommen des Fischotters (Lutra lutra). Zum Schutz dieser vom Aussterben bedrohten Art wurde 1979 im Drömling eine Fläche von 1.917 ha als Fischotterschongebiet ausgewiesen (338 Weber). Heute wird der Otterbestand im Naturpark auf der Grundlage der Verteilung aktueller Nachweise auf 2-3 Reviere geschätzt.
Gallbladder cancer (GBC) is a highly malignant tumor characterized by a poor response to chemotherapy and radiotherapy. We evaluated the in vitro and in vivo antitumor efficacy of mTOR inhibitors, rapamycin and WYE-354. In vitro assays showed WYE-354 significantly reduced cell viability, migration and invasion and phospho-P70S6K expression in GBC cells. Mice harboring subcutaneous gallbladder tumors, treated with WYE-354 or rapamycin, exhibited a significant reduction in tumor mass. A short-term treatment with a higher dose of WYE-354 decreased the tumor size by 68.6% and 52.4%, in mice harboring G-415 or TGBC-2TKB tumors, respectively, compared to the control group. By contrast, treatment with a prolonged-low-dose regime of rapamycin almost abrogated tumor growth, exhibiting 92.7% and 97.1% reduction in tumor size, respectively, compared to control mice. These results were accompanied by a greater decrease in the phosphorylation status of P70S6K and a lower cell proliferation Ki67 index, compared to WYE-354 treated mice, suggesting a more effective mTOR pathway inhibition. These findings provide a proof of concept for the use of rapamycin or WYE-354 as potentially good candidates to be studied in clinical trials in GBC patients.