Universitätspublikationen
Refine
Year of publication
Document Type
- Article (10850) (remove)
Language
- English (10850) (remove)
Has Fulltext
- yes (10850)
Keywords
- inflammation (89)
- COVID-19 (75)
- SARS-CoV-2 (60)
- cancer (42)
- apoptosis (41)
- crystal structure (41)
- aging (39)
- Inflammation (38)
- glioblastoma (38)
- autophagy (37)
Institute
- Medizin (4724)
- Physik (1477)
- Biowissenschaften (975)
- Frankfurt Institute for Advanced Studies (FIAS) (699)
- Biochemie und Chemie (654)
- Geowissenschaften (491)
- Informatik (362)
- Senckenbergische Naturforschende Gesellschaft (341)
- Institut für Ökologie, Evolution und Diversität (330)
- E-Finance Lab e.V. (286)
- Gesellschaftswissenschaften (281)
- Biochemie, Chemie und Pharmazie (266)
- Biodiversität und Klima Forschungszentrum (BiK-F) (266)
- Psychologie (264)
- Exzellenzcluster Makromolekulare Komplexe (165)
- Wirtschaftswissenschaften (151)
- Psychologie und Sportwissenschaften (149)
- Pharmazie (147)
- Geowissenschaften / Geographie (118)
- Georg-Speyer-Haus (105)
- Neuere Philologien (103)
- Zentrum für Biomolekulare Magnetische Resonanz (BMRZ) (100)
- Sonderforschungsbereiche / Forschungskollegs (99)
- Sportwissenschaften (99)
- MPI für Biophysik (91)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (86)
- MPI für Hirnforschung (82)
- Rechtswissenschaft (80)
- Buchmann Institut für Molekulare Lebenswissenschaften (BMLS) (62)
- Philosophie (60)
- Informatik und Mathematik (58)
- Mathematik (57)
- Exzellenzcluster Die Herausbildung normativer Ordnungen (51)
- Deutsches Institut für Internationale Pädagogische Forschung (DIPF) (47)
- Erziehungswissenschaften (47)
- Geographie (45)
- ELEMENTS (37)
- MPI für empirische Ästhetik (37)
- Institut für Sozialforschung (IFS) (33)
- Ernst Strüngmann Institut (25)
- Sprach- und Kulturwissenschaften (25)
- Geschichtswissenschaften (24)
- Kulturwissenschaften (24)
- Präsidium (24)
- Sustainable Architecture for Finance in Europe (SAFE) (21)
- Philosophie und Geschichtswissenschaften (19)
- Center for Membrane Proteomics (CMP) (17)
- Exzellenzcluster Herz-Lungen-System (16)
- House of Finance (HoF) (14)
- Starker Start ins Studium: Qualitätspakt Lehre (14)
- Institut für sozial-ökologische Forschung (ISOE) (12)
- Universitätsbibliothek (12)
- Extern (11)
- Zentrum für Interdisziplinäre Afrikaforschung (ZIAF) (11)
- Interdisziplinäres Zentrum für Neurowissenschaften Frankfurt (IZNF) (9)
- Center for Financial Studies (CFS) (8)
- Center for Scientific Computing (CSC) (7)
- Helmholtz International Center for FAIR (7)
- LOEWE-Schwerpunkt für Integrative Pilzforschung (7)
- DFG-Forschergruppen (6)
- Sprachwissenschaften (6)
- Cornelia Goethe Centrum für Frauenstudien und die Erforschung der Geschlechterverhältnisse (CGC) (5)
- Goethe-Zentrum für Wissenschaftliches Rechnen (G-CSC) (5)
- Institute for Monetary and Financial Stability (IMFS) (5)
- Hochschulrechenzentrum (4)
- Institut für Wirtschaft, Arbeit, und Kultur (IWAK) (4)
- Evangelische Theologie (3)
- Hessische Stiftung für Friedens- und Konfliktforschung (HSFK) (3)
- LOEWE-Schwerpunkt Außergerichtliche und gerichtliche Konfliktlösung (3)
- Universität des 3. Lebensalters e.V. (3)
- Interdisziplinäres Zentrum für Ostasienstudien (IZO) (2)
- Katholische Theologie (2)
- Sigmund-Freud Institut – Forschungsinstitut fur Psychoanalyse und ihre Anwendungen (2)
- keine Angabe Institut (2)
- (1)
- Akademie für Bildungsforschung und Lehrerbildung (bisher: Zentrum für Lehrerbildung und Schul- und Unterrichtsforschung) (1)
- Diagnostic Center of Acute Leukemia (1)
- Europäische Akademie der Arbeit in der Universität Frankfurt am Main (1)
- Fachübergreifend (1)
- Fachübergreifende Einrichtungen (1)
- Frobenius Institut (1)
- Institut für Bienenkunde (1)
- Wilhelm-Merton-Zentrum (1)
- Zentrum für Nordamerika-Forschung (ZENAF) (1)
- studiumdigitale (1)
The title compound, C15H25N5, is an aminalization product between 2,6-diacetylpyridine and 1,3-diaminopropane. It crystallizes with two independent molecules in the asymmetric unit with different conformations. In the first molecule, the methyl groups are cis oriented with respect to the pyridine ring [N—C—C—C torsion angles = 72.5 (1) and 80.3 (1)°], while they are trans oriented in the second molecule [N—C—C—C torsion angles = 82.6 (1) and -90.8 (1)°]. Each of the two molecules forms centrosymmetric dimers held together by N—H[cdots, three dots, centered]N hydrogen bonds, thus forming R 2 2(16) rings. The two dimers are interlinked by additional N—H[cdots, three dots, centered]N bonds into R 4 4(14) rings, building chains along the a axis. These patterns influence the orientation (either equatorial or axial) of the N—H bonds.
Neanderthal diets are reported to be based mainly on the consumption of large and medium sized herbivores, while the exploitation of other food types including plants has also been demonstrated. Though some studies conclude that early Homo sapiens were active hunters, the analyses of faunal assemblages, stone tool technologies and stable isotopic studies indicate that they exploited broader dietary resources than Neanderthals. Whereas previous studies assume taxon-specific dietary specializations, we suggest here that the diet of both Neanderthals and early Homo sapiens is determined by ecological conditions. We analyzed molar wear patterns using occlusal fingerprint analysis derived from optical 3D topometry. Molar macrowear accumulates during the lifespan of an individual and thus reflects diet over long periods. Neanderthal and early Homo sapiens maxillary molar macrowear indicates strong eco-geographic dietary variation independent of taxonomic affinities. Based on comparisons with modern hunter-gatherer populations with known diets, Neanderthals as well as early Homo sapiens show high dietary variability in Mediterranean evergreen habitats but a more restricted diet in upper latitude steppe/coniferous forest environments, suggesting a significant consumption of high protein meat resources.
Carbon-13 and oxygen-18 abundances were measured in large mammal skeletal remains (tooth enamel, dentine and bone) from the Chiwondo Beds in Malawi, which were dated by biostratigraphic correlation to ca. 2.5 million years ago. The biologic isotopic patterns, in particular the difference in carbon-13 abundances between grazers and browsers and the difference in oxygen-18 abundances between semi-aquatic and terrestrial herbivores, were preserved in enamel, but not in dentine and bone. The isotopic results obtained from the skeletal remains from the Chiwondo Beds indicate a dominance of savannah habitats with some trees and shrubs. This environment was more arid than the contemporaneous Ndolanya Beds in Tanzania. The present study confirms that robust australopithecines were able to live in relatively arid environments and were not confined to more mesic environments elsewhere in southern Africa.
A thick Middle and Late Pleistocene loess/palaeosol sequence is exposed at the gravel quarry Gaul located east of Weilbach in the southern foreland of the Taunus Mountains. The loess/palaeosol sequence correlates to the last three glacial cycles. Seven samples were dated by luminescence methods using an elevated temperature IRSL (post-IR IRSL) protocol for polymineral fine-grains to determine the deposition age of the sediment and to set up a more reliable chronological framework for these deposits. The fading corrected IR50 and the pIRIR225 age estimates show a good agreement for almost all samples. The fading corrected IRSL ages range from 23.7 ± 1.6 ka to >350 ka indicating that the oldest loess was deposited during marine isotope stage (MIS) 10 or earlier and that the humic-rich horizon (Weilbacher Humuszone) was developed during the late phase of MIS 7. Loess taken above the fCc horizon most likely accumulated during MIS 6 indicating that the remains of the palaeosol are not belonging to the last interglacial soil. The two uppermost samples indicate that the youngest loess accumulated during MIS 2 (Upper Würmian). Age estimates for the loess-palaeosol sequence of the gravel quarry Gaul/Weilbach could be obtained up to ~350 ka using the pIRIR225 from feldspar. Keywords: loess, luminescence dating, IRSL, fading, Weilbach, chronostratigraphy
We present simulations with the Chemical Lagrangian Model of the Stratosphere (CLaMS) for the Arctic winter 2002/2003. We integrated a Lagrangian denitrification scheme into the three-dimensional version of CLaMS that calculates the growth and sedimentation of nitric acid trihydrate (NAT) particles along individual particle trajectories. From those, we derive the HNO3 downward flux resulting from different particle nucleation assumptions. The simulation results show a clear vertical redistribution of total inorganic nitrogen ( ), with a maximum vortex average permanent removal of over 5ppb in late December between 500 and 550K and a corresponding increase of of over 2ppb below about 450K. The simulated vertical redistribution of is compared with balloon observations by MkIV and in-situ observations from the high altitude aircraft Geophysica. Assuming a globally uniform NAT particle nucleation rate of 7.8x10-6cm-3h-1 in the model, the observed denitrification is well reproduced.
In the investigated winter 2002/2003, the denitrification has only moderate impact (≤14%) on the simulated vortex average ozone loss of about 1.1ppm near the 460K level. At higher altitudes, above 600K potential temperature, the simulations show significant ozone depletion through -catalytic cycles due to the unusual early exposure of vortex air to sunlight.
Background: The aim of this study was to develop a child-specific classification system for long bone fractures and to examine its reliability and validity on the basis of a prospective multicentre study. Methods: Using the sequentially developed classification system, three samples of between 30 and 185 paediatric limb fractures from a pool of 2308 fractures documented in two multicenter studies were analysed in a blinded fashion by eight orthopaedic surgeons, on a total of 5 occasions. Intra- and interobserver reliability and accuracy were calculated. Results: The reliability improved with successive simplification of the classification. The final version resulted in an overall interobserver agreement of kappa=0.71 with no significant difference between experienced and less experienced raters. Conclusions: In conclusion, the evaluation of the newly proposed classification system resulted in a reliable and routinely applicable system, for which training in its proper use may further improve the reliability. It can be recommended as a useful tool for clinical practice and offers the option for developing treatment recommendations and outcome predictions in the future.
Dynamics of relativistic heavy-ion collisions is investigated on the basis of a simple (1+1)-dimensional hydrodynamical model in light-cone coordinates. The main emphasis is put on studying sensitivity of the dynamics and observables to the equation of state and initial conditions. Low sensitivity of pion rapidity spectra to the presence of the phase transition is demonstrated, and some inconsistencies of the equilibrium scenario are pointed out. Possible non-equilibrium effects are discussed, in particular, a possibility of an explosive disintegration of the deconfined phase into quark-gluon droplets. Simple estimates show that the characteristic droplet size should decrease with increasing the collective expansion rate. These droplets will hadronize individually by emitting hadrons from the surface. This scenario should reveal itself by strong non-statistical fluctuations of observables. Critical Point and Onset of Deconfinement 4th International Workshop July 9-13 2007 GSI Darmstadt,Germany
Event-by-event multiplicity fluctuations in nucleus-nucleus collisions from low SPS up to RHIC energies have been studied within the HSD transport approach. Fluctuations of baryonic number and electric charge also have been explored for Pb+Pb collisions at SPS energies in comparison to the experimental data from NA49. We find a dominant role of the fluctuations in the nucleon participant number for the final hadron multiplicity fluctuations and a strong influence of the experimental acceptance on the final results. Critical Point and Onset of Deconfinement - 4th International Workshop July 9 - 13, 2007 Darmstadt, Germany
Yuniyanti Chuzaifah is one of the founders of "Voice of Concerned Mothers" (Suara Ibu Peduli or SIP) and later joined the "Coalition of Indonesian Women" (Koalisi Perempuan Indonesia or KPI). She studied at the Universities of Leiden and Amsterdam in the Netherlands, and later returned to Indonesia. Since March 2010 she has been the Director of the "Indonesian National Commission on Violence against Women" (Komnas Perempuan). This interview was conducted on 15 March 2010 at the organisation’s premises in Jakarta.
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs) on perioperative adrenocorticotropic hormone (ACTH) and cortisol regulation in serum of cardiac surgical patients. To investigate the link to systemic inflammation in this context, we additionally measured 10 different cytokines in the serum. Methods: 338 patients admitted for elective cardiac surgery were included in this prospective observational clinical cohort study. Genomic DNA of patients was screened for TLR2 and TLR4 SNPs. Serum concentrations of ACTH, cortisol, interferon (IFN)-, interleukin (IL)-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)- and granulocyte macro-phage-colony stimulating factor (GM-CSF) were determined before surgery, immediately post surgery and on the first postoperative day. Results: 13 patients were identified as TLR2 SNP carrier, 51 as TLR4 SNP carrier and 274 pa-tients as non-carrier. Basal levels of ACTH, cortisol and cytokines did not differ between groups. In all three groups a significant, transient perioperative rise of cortisol could be ob-served. However, only in the non-carrier group this was accompanied by a significant ACTH rise, TLR4 SNP carriers had significant lower ACTH levels compared to non-carriers ((mean[95% confidence intervals]) non-carriers: 201.9[187.7 to 216.1]pg/ml; TLR4 SNP car-riers: 149.9[118.4 to 181.5]pg/ml; TLR2 SNP carriers: 176.4[110.5 to 242.3]pg/ml). Compared to non-carriers, TLR4 SNP carriers showed significant lower serum IL-8, IL-10 and GM-CSF peaks ((mean[95% confidence intervals]): IL-8: non-carriers: 42.6[36.7 to 48.5]pg/ml, TLR4 SNP carriers: 23.7[10.7 to 36.8]pg/ml; IL-10: non-carriers: 83.8[70.3 to 97.4]pg/ml, TLR4 SNP carriers: 54.2[24.1 to 84.2]pg/ml; GM-CSF: non-carriers: 33.0[27.8 to 38.3]pg/ml, TLR4 SNP carriers: 20.2[8.6 to 31.8]pg/ml). No significant changes over time or between the groups were found for the other cytokines. Conclusions: Regulation of the immunoendocrine stress response during systemic inflamma-tion is influenced by the presence of a TLR4 SNP. Cardiac surgical patients carrying this ge-notype showed decreased serum concentrations of ACTH, IL-8, IL-10 and GM-CSF. This finding might have impact on interpreting previous and designing future trials on diagnosing and modulating immunoendocrine dysregulation (e.g. adrenal insufficiency) during systemic inflammation and sepsis.