Universitätspublikationen
Refine
Year of publication
- 2015 (1739) (remove)
Document Type
- Article (603)
- Doctoral Thesis (187)
- Working Paper (169)
- Contribution to a Periodical (164)
- Book (159)
- Report (157)
- Part of Periodical (124)
- Review (70)
- Preprint (55)
- Conference Proceeding (22)
Language
- English (863)
- German (835)
- Spanish (14)
- Italian (11)
- Portuguese (11)
- French (3)
- Multiple languages (1)
- Russian (1)
Is part of the Bibliography
- no (1739)
Keywords
- Islamischer Staat (34)
- IS (25)
- Terrorismus (23)
- Deutschland (16)
- Dschihadismus (13)
- Syrien (12)
- Terror (11)
- Irak (10)
- Islamismus (10)
- Salafismus (10)
Institute
- Präsidium (336)
- Medizin (252)
- Gesellschaftswissenschaften (230)
- Physik (184)
- Wirtschaftswissenschaften (149)
- Exzellenzcluster Die Herausbildung normativer Ordnungen (116)
- Center for Financial Studies (CFS) (115)
- Biowissenschaften (99)
- Informatik (96)
- Frankfurt Institute for Advanced Studies (FIAS) (95)
There are only 3 methods for the production of heavy and superheavy (SH) nuclei, namely, fusion reactions, a sequence of neutron capture and beta(-) decay and multinucleon transfer reactions. Low values of the fusion cross sections and very short half-lives of nuclei with Z<120 put obstacles in synthesis of new elements. At the same time, an important area of SH isotopes located between those produced in the cold and hot fusion reactions remains unstudied yet. This gap could be filled in fusion reactions of 48Ca with available lighter isotopes of Pu, Am, and Cm. New neutron-enriched isotopes of SH elements may be produced with the use of a 48Ca beam if a 250Cm target would be prepared. In this case we get a real chance to reach the island of stability owing to a possible beta(+) decay of 291114 and 287112 nuclei formed in this reaction with a cross section of about 0.8 pb. A macroscopic amount of the long-living SH nuclei located at the island of stability may be produced by using the pulsed nuclear reactors of the next generation only if the neutron fluence per pulse will be increased by about three orders of magnitude. Multinucleon transfer processes look quite promising for the production and study of neutron-rich heavy nuclei located in upper part of the nuclear map not reachable by other reaction mechanisms. Reactions with actinide beams and targets are of special interest for synthesis of new neutron-enriched transfermium nuclei and not-yet-known nuclei with closed neutron shell N=126 having the largest impact on the astrophysical r-process. The estimated cross sections for the production of these nuclei allows one to plan such experiments at currently available accelerators.
In eukaryotic cells, mitochondria host ancient essential bioenergetic and biosynthetic pathways. LYR (leucine/tyrosine/arginine) motif proteins (LYRMs) of the Complex1_LYR-like superfamily interact with protein complexes of bacterial origin. Many LYR proteins function as extra subunits (LYRM3 and LYRM6) or novel assembly factors (LYRM7, LYRM8, ACN9 and FMC1) of the oxidative phosphorylation (OXPHOS) core complexes. Structural insights into complex I accessory subunits LYRM6 and LYRM3 have been provided by analyses of EM and X-ray structures of complex I from bovine and the yeast Yarrowia lipolytica, respectively. Combined structural and biochemical studies revealed that LYRM6 resides at the matrix arm close to the ubiquinone reduction site. For LYRM3, a position at the distal proton-pumping membrane arm facing the matrix space is suggested. Both LYRMs are supposed to anchor an acyl-carrier protein (ACPM) independently to complex I. The function of this duplicated protein interaction of ACPM with respiratory complex I is still unknown. Analysis of protein-protein interaction screens, genetic analyses and predicted multi-domain LYRMs offer further clues on an interaction network and adaptor-like function of LYR proteins in mitochondria.
Background: Intestinal perforation or leakage increases morbidity and mortality of surgical and endoscopic interventions. We identified criteria for use of full-covered, extractable self-expanding metal stents (cSEMS) vs. "Over the scope"-clips (OTSC) for leak closure.
Methods: Patients who underwent endoscopic treatment for postoperative leakage, endoscopic perforation, or spontaneous rupture of the upper gastrointestinal tract between 2006 and 2013 were identified at four tertiary endoscopic centers. Technical success, outcome (e.g. duration of hospitalization, in-hospital mortality), and complications were assessed and analyzed with respect to etiology, size and location of leakage.
Results: Of 106 patients (male: 75 (71%), female: 31 (29%); age (mean ± SD): 62.5 ± 1.3 years, 72 (69%) were treated by cSEMS and 34 (31%) by OTSC. For cSEMS vs. OTSC, mean treatment duration was 41.1 vs. 25 days, p<0.001, leakage size 10 (1-50) vs. 5 (1-30) mm (median (range)), and complications were observed in 68% vs. 8.8%, p<0.001, respectively. Clinical success for primary interventional treatment was observed in 29/72 (40%) vs. 24/34 (70%, p = 0.006), and clinical success at the end of follow-up was 46/72 (64%) vs. 29/34 (85%) for patients treated by cSEMS vs. OTSC; p = 0.04.
Conclusion: OTSC is preferred in small-sized lesions and in perforation caused by endoscopic interventions, cSEMS in patients with concomitant local infection or abscess. cSEMS is associated with a higher frequency of complications. Therefore, OTSC might be preferred if technically feasible. Indication criteria for cSEMS vs. OTSC vary and might impede design of randomized studies.
Background: The sodium-taurocholate cotransporting polypeptide (NTCP) is both a key bile acid (BA) transporter mediating uptake of BA into hepatocytes and an essential receptor for hepatitis B virus (HBV) and hepatitis D virus (HDV). In this study we aimed to characterize to what extent and through what mechanism BA affect HDV cell entry.
Methods: HuH-7 cells stably expressing NTCP (HuH-7/NTCP) and primary human hepatocytes (PHH) were infected with in vitro generated HDV particles. Infectivity in the absence or presence of compounds was assessed using immunofluorescence staining for HDV antigen, standard 50% tissue culture infectious dose (TCID50) assays and quantitative PCR.
Results: Addition of primary conjugated and unconjugated BA resulted in a dose dependent reduction in the number of infected cells while secondary, tertiary and synthetic BA had a lesser effect. This effect was observed both in HuH-7/NTCP and in PHH. Other replication cycle steps such as replication and particle assembly and release were unaffected. Moreover, inhibitory BA competed with a fragment from the large HBV envelope protein for binding to NTCP-expressing cells. Conversely, the sodium/BA-cotransporter function of NTCP seemed not to be required for HDV infection since infection was similar in the presence or absence of a sodium gradient across the plasma membrane. When chenodeoxycolic acid (15 mg per kg body weight) was administered to three chronically HDV infected individuals over a period of up to 16 days there was no change in serum HDV RNA.
Conclusions: Primary BA inhibit NTCP-mediated HDV entry into hepatocytes suggesting that modulation of the BA pool may affect HDV infection of hepatocytes.
The practical aim of this work is twofold. Firstly, it is to construct a theory of language based on historical-materialist premises, i.e. a theory which stresses the sociality and historicity of language, and finds in them the fundamental characteristics which make language one of the central phenomena of human life. Such a theory is inherently counterposed to the dominant theories and philosophies of language in the last century, be they Saussurean, idealistic, structuralist, psychologistic or Chomskyan etc. It also rejects vulgar materialistic accounts of language, where language is seen merely as a “reflection” of the economic base of society, as well as the version proposed in Stalin’s short pamphlet, Marxism and Linguistics, which sees language merely as a means of communication, regardless of society or class, therefore neutralised and consequently branded irrelevant for Marxist theory. In short, the first aim would be showing what language is not and what it cannot be by showing what it is.
The second aim is related to Marxist theory in general. Following the presuppositions of this work, a Marxist account of language proves to be an immensely important field of research for Marxism. The reasons are fairly simple, if one is willing to accept them: language is a certain type of social practice, it is related to the way people act, which also means that it is interconnected with consciousness, i.e. to the way people think and to the content of their thought. Language is ideological and political; it is an element of class rule and class struggle. Thus, understanding language should be of utmost importance for any socialist revolutionary project, as ideological struggle is central not only to a revolutionary period, but, perhaps even more, to a period where revolution is not even in sight. I do not wish to derogate other Marxist fields of research, but, on the contrary, to simply insist on their equal importance. Ideological phenomena should not be a secondary or inferior object of research to strictly economic phenomena, or vice-versa. In reality, those phenomena form a dialectic unity; only if theory follows suit, can a pregnant Marxist philosophy be formed.
Teil VIII unserer Serie zum “Islamischen Staat”: "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat".
Die Kurden feiern in diesen Tagen den Sieg über den Islamischen Staat in Kobane. Die Hauptstadt des Distrikts Ain al-Arab im Gouvernement Aleppo in Syrien liegt nahe der syrisch-türkischen Grenze. Seit Anfang 2014 ist Ain al-Arab Zentrum eines der drei selbstverwalteten Kantone Rojavas. Diese Kantone stehen unter der Kontrolle der kurdischen “Partei der Demokratischen Union” (PYD) und ihrer Verbündeten. Die PYD ist eine Schwesterpartei der PKK, sie erkennt Abdullah Öcalan als ideologischen Führer an...
Teil VII unserer Serie zum “Islamischen Staat”: "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat".
Viel ist in den letzten Wochen und Monaten über den so genannten „Islamischen Staat“, ISIS oder ISIL gesprochen und geschrieben worden. Die „abstrakte Bedrohungslage“, die von der „Terrormiliz“ und ihren Anhängern ausgeht, scheint jedoch der deutschen Öffentlichkeit kaum deutlicher vor Augen geführt zu werden, als bei den Demonstrationen, die von Dresden ausgehend seit geraumer Zeit in verschiedenen Großstädten stattfinden bzw. stattgefunden haben. Die Wendung gegen das Austragen von „Glaubenskriegen auf deutschem Boden“ und noch deutlicher die Sorge vor einer bevorstehenden „Islamisierung des Abendlandes“, speist sich bei diesen zu einem gewissen Teil auch aus den Bildern und Tönen, die von und über den Islamischen Staat mittels unterschiedlicher Medienkanäle verbreitet werden. Zudem werden Befürchtungen artikuliert, die durch den Islamischen Staat ausgelösten Flüchtlingswellen bewirkten einen signifikanten Zuzug von Muslimen, der zu tiefgreifenden sozio-kulturellen Veränderungen führe...
Part VI of our series on ISIS : "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat".
In 2014, two insurgency organisations stood out by their expansion, success and brutality: The Islamic State (IS) and Boko Haram (BH). The former emerged from the conflicts in Syria and Iraq and became a major actor in the Middle East, its influence reaching beyond the borders of its self-proclaimed “caliphate”, while the latter spread its violence throughout north-eastern Nigeria, spilling over into Cameroon, Chad and Niger. Because of their still growing success, many wonder about a possible partnership between IS and BH. To this I answer that there is a connection, but no partnership. Currently, any evidence suggesting a partnership is circumstantial at best...
Part V of our series on ISIS : "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat".
Since 2003, several organizations in the Arab world swore allegiance to Osama Bin Laden and al-Qaida and became part of what was been called “al-Qaeda’s affiliate network”. The emergence of al-Qaeda groups in Saudi Arabia 2003, Iraq 2004, Algeria 2007 and Yemen 2009 convinced many supporters and enemies that there was a truly global network of jihadist groups at work, commanded and controlled by the al-Qaeda leadership in Pakistan.
However, the reality was a lot more complicated. Far from being subordinate to Osama Bin Laden and Aiman al-Zawahiri, these organizations were not willing to submit to al-Qaeda command and control. Their relationship with “al-Qaeda central” was rather an alliance between independent partners of different strength. Although the al-Qaeda leadership sometimes influenced decisions taken by the regional groupings, there are numerous examples of “affiliates” ignoring its advice even regarding strategic issues.
Part IV of our series on ISIS : "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat".
One element within US counter-terrorism strategies is “reducing terrorist group cohesion”, as the think tank RAND recommends in one of its reports. The Combating Terrorism Center at West Point (CTC) puts these recommendations into actions. Reports like ”Cracks in the Foundation” or ”Dysfunction and Decline” vividly depict the internal disagreement and disunity between al-Qaeda central (AQ) and its regional affiliates, most of all AQ in Iraq (AQI). Albeit these reports are drafted by pundits and certainly provide meaningful and often rare insights into the inner life of the global jihadi movement, they also serve another purpose: to deliberately amplify the very same trend they describe: disunity...
ISIS' politics of sex
(2015)
Part III of our series on ISIS : "Blogforum 'Kalifat des Terrors: Interdisziplinäre Perspektiven auf den Islamischen Staat#".
In the late summer of 2014, the international community watched helplessly as ISIS unleashed widespread serious human rights violations against civilians across Syria and Iraq. Of note, were the different forms of sexual abuse initially directed against women from the Yazidi community of Sinjar, but rapidly expanded to women from many regions and backgrounds. Far from being attributable to isolated incidents or to the behavior of a few individuals, the abuses were, and continue to be, part of the “sexual politics” implemented by ISIS in all “wilayas” (regions) under its control and endorsed by its military hierarchy. The abuses represent a clear example of the use of rape as a weapon of war, based on the “theology of sexuality” in a war zone. Fatwas and theological arguments inspired by the medieval practices of historical Muslim armies provide the justification for the policies and practices.
Some observers have conjectured that oil supply shocks in the United States and in other countries are behind the plunge in the price of oil since June 2014. Others have suggested that a major shock to oil price expectations occurred when in late November 2014 OPEC announced that it would maintain current production levels despite the steady increase in non-OPEC oil production. Both conjectures are perfectly reasonable ex ante, yet we provide quantitative evidence that neither explanation appears supported by the data. We show that more than half of the decline in the price of oil was predictable in real time as of June 2014 and therefore must have reflected the cumulative effects of earlier oil demand and supply shocks. Among the shocks that occurred after June 2014, the most influential shock resembles a negative shock to the demand for oil associated with a weakening economy in December 2014. In contrast, there is no evidence of any large positive oil supply shocks between June and December. We conclude that the difference in the evolution of the price of oil, which declined by 44% over this period, compared with other commodity prices, which on average only declined by about 5%-15%, reflects oil-market specific developments that took place prior to June 2014.
This paper is motivated by the fact that nearly half of U.S. college students drop out without earning a bachelor’s degree. Its objective is to quantify how much uncertainty college entrants face about their graduation outcomes. To do so, we develop a quantitative model of college choice. The innovation is to model in detail how students progress towards a college degree. The model is calibrated using transcript and financial data. We find that more than half of college entrants can predict whether they will graduate with at least 80% probability. As a result, stylized policies that insure students against the financial risks associated with uncertain graduation have little value for the majority of college entrants.
Little attention so-far has been paid to the influence of chronobiology on the processes of nanoparticle uptake and transport into the brain, even though this transport appears to be chronobiologically controlled to a significant degree. Nanoparticles with specific surface properties enable the transport across the blood–brain barrier of many drugs that normally cannot cross this barrier. A clear dependence of the central antinociceptive (analgesic) effects of a nanoparticle-bound model drug, i.e., the hexapeptide dalargin, on the time of day was observable after intravenous injection in mice. In addition to the strongly enhanced antinociceptive effect due to the binding to the nanoparticles, the minima and maxima of the pain reaction with the nanoparticle-bound drug were shifted by almost half a day compared to the normal circadian nociception: The maximum in the pain reaction after i.v. injection of the nanoparticle-bound dalargin occurred during the later rest phase of the animals whereas the normal pain reaction and that of a dalargin solution was highest during the active phase of the mice in the night. This important shift could be caused by an enhanced endo- and exocytotic particulates transport activity of the brain capillary endothelial cells or within the brain during the rest phase.
Microtubules execute diverse mitotic events that are spatially and temporally separated; the underlying regulation is poorly understood. By combining drug treatments, large-scale immunoprecipitation and mass spectrometry, we report the first comprehensive map of mitotic phase-specific protein interactions of the microtubule-end binding protein, EB1. EB1 interacts with some, but not all, of its partners throughout mitosis. We show that the interaction of EB1 with Astrin-SKAP complex, a key regulator of chromosome segregation, is enhanced during prometaphase, compared to anaphase. We find that EB1 and EB3, another EB family member, can interact directly with SKAP, in an SXIP-motif dependent manner. Using an SXIP defective mutant that cannot interact with EB, we uncover two distinct pools of SKAP at spindle microtubules and kinetochores. We demonstrate the importance of SKAP's SXIP-motif in controlling microtubule growth rates and anaphase onset, without grossly disrupting spindle function. Thus, we provide the first comprehensive map of temporal changes in EB1 interactors during mitosis and highlight the importance of EB protein interactions in ensuring normal mitosis.
Seit einem Jahr ist im Umfeld der Vereinten Nationen immer wieder von einem „Human Rights Up Front Aktionsplan“ zu hören. Erst kürzlich forderte Generalsekretär Ban Ki-moon die Mitgliedstaaten in einer Ansprache zu den Prioritäten der UN 2015 auf den Aktionsplan zu unterstützen. Doch was ist das für eine Initiative und welche Resultate hat sie bislang hervorgebracht? Diesen Fragen geht dieser Beitrag auf den Grund.