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Objective: Nationwide data on the epidemiology, treatment characteristics, and long-term outcome of severe traumatic brain injury (TBI) in Germany is not yet existing. Neurosurgeons from the German Neurosurgery Society (DGNC) and traumatologists from the German Trauma Society (DGU), therefore, joined forces in 2016 to conceptualize a TBI module for the well-established Trauma Register of the DGU (TR-DGU). Here, we report how this “German National TBI registry (GNTR)” has been developed, implemented, and tested in a recently completed pilot period.
Methods: The conception and implementation process of the GNTR from August 2016 to February 2019 is described, and results of its 23-months long pilot period from February 2019 to December 2020 are presented. For the pilot period, TBI patients were prospectively enrolled at nine neurosurgical and traumatological hospitals across Germany. Inclusion criteria were treatment on the ICU ≥ 24h, or an ISS score ≥ 16. A variety of clinical, imaging, and laboratory parameters were collected, and the GOSE score was used to assess the outcome at discharge and 6- and 12 months follow-up.
Results: Details on the structure and dataset of the GNTR as well as milestones and pitfalls during its conception and implementation, are outlined. During the pilot period, a total of 264 TBI patients were enrolled. Their demographic characteristics, clinical, imaging, and radiological findings, and their early mortality and functional outcome are described. Furthermore, factors associated with an unfavorable outcome (GOSE 1-4) are assessed using uni- and multivariate regression analyses. Finally, problems and future directions of the GNTR are discussed.
Conclusion: The pilot period of the GNTR offers a first glance at the current epidemiology and treatment characteristics of TBI patients in Germany. More importantly, they show how a national TBI registry yielding high-quality prospective data can be developed, implemented, and tested within four years
We consider a dual representation of an effective three-dimensional Polyakov loop model for the SU(3) theory at nonzero real chemical potential. This representation is free of the sign problem and can be used for numeric Monte-Carlo simulations. These simulations allow us to locate the line of second order phase transitions, that separates the region of first order phase transition from the crossover one. The behavior of local observables in different phases of the model is studied numerically and compared with predictions of the mean-field analysis. Our dual formulation allows us to study also Polyakov loop correlation functions. From these results, we extract the screening masses and compare them with large-N predictions.
The magnetic fields generated in non-central heavy-ion collisions are among the strongest fields produced in the Universe, reaching magnitudes comparable to the scale of the strong interactions. Backed by model simulations, the resulting field is expected to be spatially modulated, deviating significantly from the commonly considered uniform profile. To improve our understanding of the physics of quarks and gluons under such extreme conditions, we use lattice QCD simulations with 2+1 staggered fermion flavors with physical quark masses and an inhomogeneous magnetic background for a range of temperatures covering the QCD phase transition. We assume a 1/cosh2 function to model the field profile and vary its strength to analyze the impact on the computed observables and on the transition. We calculate local chiral condensates, local Polyakov loops and estimate the size of lattice artifacts. We find that both observables show non-trivial spatial features due to the interplay between the sea and the valence effects.
The broad class of U(N) and SU(N) Polyakov loop models on the lattice are solved exactly in the combined large N, Nf limit, where N is a number of colors and Nf is a number of quark flavors, and in any dimension. In this ’t Hooft-Veneziano limit the ratio N/Nf is kept fixed. We calculate both the free energy and various correlation functions. The critical behavior of the models is described in details at finite temperatures and non-zero baryon chemical potential. Furthermore, we prove that the calculation of the N-point (baryon) correlation function reduces to the geometric median problem in the confinement phase. In the deconfinement phase we establish an existence of the complex masses and an oscillating decay of correlations in a certain region of parameters.
According to perturbation theory predictions, QCD matter in the zero-temperature, high-density limits of QCD at nonzero isospin chemical potential is expected to be in a superfluid Bardeen-Cooper-Schrieffer (BCS) phase of u and d¯ Cooper pairs. It is also expected, on symmetry grounds, that such phase connects via an analytical crossover to the phase with Bose-Einstein condensation (BEC) of charged pions at μI≥mπ/2. With lattice results, showing some indications that the deconfinement crossover also smoothly penetrates the BEC phase, the conjecture was made that the former connects continuously to the BEC-BCS crossover. We compute the spectrum of the Dirac operator, and use generalized Banks-Casher relations, to test this conjecture and identify signatures of the superfluid BCS phase.