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Empathie ist ein mehrdimensionales psychologisches Konstrukt, das aus verschiedenen Facetten besteht (Decety & Ickes, 2011). Es ist anzunehmen, dass Empathie ein wichtiger Mechanismus ist, um Menschen miteinander zu verbinden und eine Gruppenkohäsion möglich zu machen (Rameson & Lieberman, 2009). Neben der Fähigkeit die Erlebenswelt des Gegenübers mit eigenen mentalen Repräsentationen nachzuvollziehen, werden dadurch Emotionen ausgelöst, die denen des Gegenübers sehr ähnlich sind. Gleichzeitig unterscheidet sich dieses Gefühlserleben aber beispielsweise von reiner Gefühlsansteckung, da eine Selbst-Andere Differenzierung stattfindet und in einer empathischen Episode immer im Vordergrund steht, dass man sich aufgrund der Gefühle des anderen so fühlt (Altmann, 2015). Hier spielt Imitation eine wichtige Rolle, wenn es darum geht, die Erlebenswelt der anderen Person zu erfassen (Meltzoff & Decety, 2003). Besonders auch bei Lehrkräften zeigt sich eine Wichtigkeit von empathischem Handeln und Verstehen (Tausch & Tausch, 2008). In verschiedenen Studien zeigten sich positive Effekte von Empathie auf die Schülerschaft und die Unterrichtsqualität. Die SchülerInnen trauen sich mehr, es herrscht weniger Angst im Klassenzimmer und die Qualität der Unterrichtsbeiträge steigt (vgl. Tausch & Tausch, 1998). Empathie selbst besteht aus State- und Trait-Anteilen, so dass zumindest Teile davon trainierbar sind (Butters, 2010). Eine potentielle Möglichkeit um Empathie zu fördern scheint das Lehr-Lern-Format Service Learning (SL) darzustellen. Hierbei handelt es sich um ein Veranstaltungskonzept, bei dem ein meist fachlicher, akademischer Inhalt mit einem ehrenamtlichen Engagement außerhalb der Universität verknüpft wird (Reinders, 2016). Forschung aus dem angloamerikanischen Raum weist darauf hin, dass Empathie durch derartige Formate gefördert werden kann (Lundy, 2007; Wilson, 2011). Da die meisten Messverfahren von Empathie auf Selbstauskunft basieren und damit nur indirekt Anteile wie das affektive Mitschwingen abbilden können, war es Teil dieser Arbeit im ersten Schritt einen objektiven, videobasierten Test zu entwickeln, der dann mit anderen Verfahren zur Messung eingesetzt werden sollte. In zwei ExpertInnen-Befragungen wurden aus einem Pool von Videosequenzen mit Unterrichtssituationen insgesamt zehn Videoclips mit jeweils vier Items und zugehörigen Antwortoptionen extrahiert. In einer darauf folgenden Validierung mit Studierenden der Goethe-Universität (N = 112) wurden diese Vignetten mit verschiedenen Verfahren zur Messung von Empathie gemeinsam erhoben und die Zusammenhänge analysiert. Die Reliabilitäten der drei Testscores bewegten sich in den beiden gebildeten Testversionen zwischen Cronbachs α = .53 (Verhaltens-Score der Testversion 1) und α = .76 (Intensitäts-Score der Testversion 2). Es zeigten sich zu allen Fragebögen erwartungskonforme Zusammenhänge von kleinen bis mittleren Effekten. Die Itemschwierigkeiten bei den meisten Items lagen zwischen 50 und 65, die Trennschärfen zwischen .18 und .70.
Im nächsten Entwicklungsschritt wurden die Vignetten in neu zusammengestellten Testversionen nur Lehramtsstudierenden (N = 41) vorgelegt und zusätzlich Videoaufnahmen der Gesichter der ProbandInnen gemacht, um sie mit Face-Reader zu analysieren und die Facette Mitschwingen abzubilden. Die Reliabilitäten der Testversionen lagen mit einem neuen Scoring nun zwischen α = .24 (Emotionserkennungs-Score Prä-Testversion) und
α = .57 (Intensitäts-Score Prä-Testversion) sowie zwischen α = .10 (Emotionserkennungs-Score Post-Testversion) und α = .77 (Intensitäts-Score Post-Testversion). Auch die Schwierigkeiten und Trennschärfen änderten sich nach Adaptieren des Scorings und bewegten sich in beiden Testversionen nun von 30 bis 89 (Schwierigkeit) und von .0 bis .5 (Trennschärfe). Die Face-Reader Analysen zeigten nur in Teilen kongruente Emotionen mit den Selbstauskunftsdaten bzw. den eingeschätzten Intensitäten in den Videosequenzen, dann allerdings mittlere bis große Effekte, so dass in Teilen von einem affektiven Mitschwingen ausgegangen werden kann. Da sich die internen Konsistenzen im Vergleich zur Validierung verschlechterten, wurden die Zusammensetzungen der Testversionen für den Praxiseinsatz wieder auf die Validierungs-Versionen umgestellt.
Im Praxiseinsatz wurden Lehramtsstudierende in SL und Non-SL-Veranstaltungen rekrutiert und miteinander verglichen. Insgesamt nahmen N = 68 Personen an drei Messzeitpunkten teil (n = 30 in SL und n = 38 in Non-SL-Seminaren). Die Analysen zeigten, dass es zwischen den Gruppen keine signifikanten Unterschiede in den genutzten Instrumenten gab. Auch über die Zeit gab es nach der Bonferroni-Korrektur nur einen signifikanten Effekt (F (2,52) = 6.57, p = .003, η2 = .20). Es ist anzunehmen, dass diese Ergebnisse vor allem auf methodische Einschränkungen und Verbesserungsmöglichkeiten des entwickelten Testverfahrens zurückzuführen sind. Weitere Möglichkeiten werden diskutiert.
The authors embed human capital-based endogenous growth into a New-Keynesian model with search and matching frictions in the labor market and skill obsolescence from long-term unemployment. The model can account for key features of the Great Recession: a decline in productivity growth, the relative stability of inflation despite a pronounced fall in output (the "missing disinflation puzzle"), and a permanent gap between output and the pre-crisis trend output.
In the model, lower aggregate demand raises unemployment and the training costs associated with skill obsolescence. Lower employment hinders learning-by-doing, which slows down human capital accumulation, feeding back into even fewer vacancies than justified by the demand shock alone. These feedback channels mitigate the disinflationary effect of the demand shock while amplifying its contractionary effect on output. The temporary growth slowdown translates into output hysteresis (permanently lower output and labor productivity).
Occasionally binding constraints have become an important part of economic modelling, especially since western central banks see themselves (again) constraint by the so-called zero lower bound (ZLB) of the nominal interest rate. A binding ZLB constraint poses a major problem for a quantitative-structural analysis: Linear solution methods do no work in the presence of a non-linearity such as the ZLB and existing alternatives tend to be computationally demanding. The urge to study macroeconomic questions related to the Great Recession and the Covid-19 crisis in a quantitative-structural framework requires algorithms that are not only accurate, but that are also robust, fast, and computationally efficient.
A particularly important application where efficient and fast methods for occasionally binding constraints (OBCs) are needed is the Bayesian estimation of macroeconomic models. This paper shows that a linear dynamic rational expectations system with OBCs, depending on the expected duration of the constraint, can be represented in closed form. Combined with a set of simple equilibrium conditions, this can be exploited to avoid matrix inversions and simulations at runtime for signifcant gains in computational speed.
Central banks sometimes evaluate their own policies. To assess the inherent conflict of interest, the authors compare the research findings of central bank researchers and academic economists regarding the macroeconomic effects of quantitative easing (QE). They find that central bank papers report larger effects of QE on output and inflation. Central bankers are also more likely to report significant effects of QE on output and to use more positive language in the abstract. Central bankers who report larger QE effects on output experience more favorable career outcomes. A survey of central banks reveals substantial involvement of bank management in research production.
Empirical estimates of equilibrium real interest rates are so far mostly limited to advanced economies, since no statistical procedure suitable for a large set of countries is available. This is surprising, as equilibrium rates have strong policy implications in emerging markets and developing economies as well; current estimates of the global equilibrium rate rely on only a few countries; and estimates for a more diverse set of countries can improve understanding of the drivers. The authors propose a model and estimation strategy that decompose ex ante real interest rates into a permanent and transitory component even with short samples and high volatility. This is done with an unobserved component local level stochastic volatility model, which is used to estimate equilibrium rates for 50 countries with Bayesian methods.
Equilibrium rates were lower in emerging markets and developing economies than in advanced economies in the 1980s, similar in the 1990s, and have been higher since 2000. In line with economic integration and rising global capital markets, synchronization has been rising over time and is higher among advanced economies. Equilibrium rates of countries with stronger trade linkages and similar demographic and economic trends are more synchronized.
With the second wave of the Covid-19 pandemic in full swing, banks face a challenging environment. They will need to address disappointing results and adverse balance sheet restatements, the intensity of which depends on the evolution of the euro area economies. At the same time, vulnerable banks reinforce real economy deficiencies. The contribution of this paper is to provide a comparative assessment of the various policy responses to address a looming banking crisis. Such a crisis will fully materialize when non-performing assets drag down banks simultaneously, raising the specter of a full-blown systemic crisis. The policy responses available range from forbearance, recapitalization (with public or private resources), asset separation (bad banks, at national or EU level), to debt conversion schemes. We evaluate these responses according to a set of five criteria that define the efficacy of each. These responses are not mutually exclusive, in practice, as they have never been. They may also go hand in hand with other restructuring initiatives, including potential consolidation in the banking sector. Although we do not make a specific recommendation, we provide a framework for policymakers to guide them in their decision making.
This policy white paper shows, using data on European Commission (EC) lobby meetings, that financial institutions and finance trade associations have substantial access to EC policymakers. While lobbying could transfer policy-relevant information and expertise to policymakers, it could also result in the capture of policymakers by the industry, which could harm consumers and taxpayers. How could policymakers prevent regulatory capture, but retain the benefits of the sector expertise in policy decisions? Awareness of regulatory capture by policymakers is one of the most important remedies. This paper provides an overview of the origins of the regulatory capture theory and recent academic evidence. The paper shows that regulatory capture could emerge in a variety of institutions and policy areas but is not ubiquitous and depends on the incentives of policymakers and the policy environment. Subsequently, the paper discusses various measures to prevent regulatory capture, such as more transparency, diverse expert groups, and cooling-off periods.
The genetic background of pain is becoming increasingly well understood, which opens up possibilities for predicting the individual risk of persistent pain and the use of tailored therapies adapted to the variant pattern of the patient’s pain-relevant genes. The individual variant pattern of pain-relevant genes is accessible via next-generation sequencing, although the analysis of all “pain genes” would be expensive. Here, we report on the development of a cost-effective next generation sequencing-based pain-genotyping assay comprising the development of a customized AmpliSeq™ panel and bioinformatics approaches that condensate the genetic information of pain by identifying the most representative genes. The panel includes 29 key genes that have been shown to cover 70% of the biological functions exerted by a list of 540 so-called “pain genes” derived from transgenic mice experiments. These were supplemented by 43 additional genes that had been independently proposed as relevant for persistent pain. The functional genomics covered by the resulting 72 genes is particularly represented by mitogen-activated protein kinase of extracellular signal-regulated kinase and cytokine production and secretion. The present genotyping assay was established in 61 subjects of Caucasian ethnicity and investigates the functional role of the selected genes in the context of the known genetic architecture of pain without seeking functional associations for pain. The assay identified a total of 691 genetic variants, of which many have reports for a clinical relevance for pain or in another context. The assay is applicable for small to large-scale experimental setups at contemporary genotyping costs.
In den letzen 30 bis 40 Jahren sind Kommunen verstärkt dazu übergegangen die in ihrem Besitz befindlichen Flächen zu verkaufen und so ihre kommunalen Gestaltungsspielräume zu verlieren. Diese Privatisierungspolitik der „unternehmerischen Stadt“ hat verkannt, dass Boden für Kommunen ein endliches und essentielles Gut ist, welches nicht vermehrt werden kann.
Gerade in den lokalen Räumen der Kommunen wird der Kampf um den begrenzten Boden besonders sichtbar. Das Alltagsleben der Menschen wird dadurch bestimmt, ob Boden im Privateigentum ist und vorrangig der Kapitalvermehrung dient oder ob Boden ein gesellschaftliches Gemeingut ist. Die Privatisierung neoliberaler Kommunalpolitik hat – entgegen der Erwartungen – weder das Leben in den Städten besser noch günstiger gemacht. Die Kosten für Mieten und die privatisierten Leistungen aus Daseinsvorsorge sind in den letzten Jahrzehnten extrem gestiegen. Letztere wurden z. T. auch verkleinert oder vollkommen aufgegeben, wie z. B. der öffentliche Nahverkehr in ländlichen Räumen oder die Schließungen von Kultureinrichtungen, Jugendzentren oder Schwimmbädern.
Auf diese Phase neoliberaler Bodenpolitik ist zunehmend eine polanyische Gegenbewegung zu beobachten, die für den sozial-ökologischen Schutz eintritt. Die Menschen in den Kommunen wollen und können diese Entwicklung nicht weiter hinnehmen. Und auch die Lokalpolitik schwenkt z. T. um, indem sie Forderungen der Rekommunaliserung und sozialverträglicher Mieten unterstützt.
Trotz dieser progressiven Entwicklungen ist gerade die Vergabe von Gewerbeflächen nach wie vor durch ein neoliberales Paradigma der Standortkonkurrenz und Austerität geprägt. In diesem Sinne muss die Vergabe von Boden zuallererst ökonomisch sinnvoll sein. Andere Aspekte werden oft ausgeklammert, da sie unter Finanzierungsvorbehalt stehen. Diese Vergabepraxis ist quasi alternativlos und damit postpolitisch. Obwohl diese Entscheidungen die Kommunen langfristig prägen, werden soziale und ökologische Aspekte der ökonomischen Frage untergeordnet. Die Berücksichtigung von Gemeinwohlaspekten, die sich in einem Kriterienkatalog zur Gewerbeflächenvergabe wiederfinden können, bietet Kommunen die Möglichkeit, eine andere – gemeinwohlorientierte – Handlungsrationalität einzunehmen. Die Entscheidungsgrundlage für die Gewerbeflächenvergabe würden mit solchen Kriterien grundlegend neu justiert werden, da sie nicht mehr auf rein ökonomischen, sondern auf sozialen und ökologischen Werten beruht.
Die vorliegende Arbeit beschäftigt sich mit der Frage, wie eine gemeinwohlorientierte Gewerbeflächenvergabe gestaltet werden kann, indem sie die kommunalen Handlungsspielräume erweitert und so einen Beitrag für eine sozial-ökologische Gegenbewegung zur neoliberalen Kommunalpolitik leistet. Sie kommt zu dem Ergebnis, dass für eine kommunale sozial-ökologische Transformation die Wirtschaft wieder stärker in die Gesellschaft eingebettet werden muss (Polanyi 1944). Eine dementsprechende Gewerbeflächenvergabe setzt daher auf die Dekommodifizierung der Flächen, d. h. sie fördert öffentliche und kollektive Eigentumsformen. Außerdem fördert sie kollektive sozial-ökologische Nutzungsformen der Flächen, die dem Gemeinwohl der Bewohner*innen in der Region dienen. Zur Umsetzung könnten Kommunen Gemeinwohl-Kriterien zur Gewerbeflächenvergabe aufstellen. In der vorliegenden Arbeit wird hierzu ein möglicher Kriterienkatalog entwickelt.
Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents in clinical trials. We retrospectively compared bortezomib (BTZ; n = 138) or LEN (n = 183) MT from two subsequent GMMG phase III trials. All patients received three cycles of BTZ-based triplet induction and post-ASCT MT. BTZ MT (1.3 mg/m2 i.v.) was administered every 2 weeks for 2 years. LEN MT included two consolidation cycles (25 mg p.o., days 1–21 of 28 day cycles) followed by 10–15 mg/day for 2 years. The BTZ cohort more frequently received tandem ASCT (91% vs. 33%) due to different tandem ASCT strategies. In the LEN and BTZ cohort, 43% and 46% of patients completed 2 years of MT as intended (p = 0.57). Progression-free survival (PFS; HR = 0.83, p = 0.18) and overall survival (OS; HR = 0.70, p = 0.15) did not differ significantly with LEN vs. BTZ MT. Patients with <nCR after first ASCT were assigned tandem ASCT in both trials. In patients with <nCR and tandem ASCT (LEN: n = 54 vs. BTZ: n = 84), LEN MT significantly improved PFS (HR = 0.61, p = 0.04) but not OS (HR = 0.46, p = 0.09). In conclusion, the significant PFS benefit after eliminating the impact of different tandem ASCT rates supports the current standard of LEN MT after ASCT.
The working paper reflects on the status that "sciences" have held at different points in time, and on the normative orders found in scientific works, as well as on the normative orders imposed by the sciences of a particular place and time on their environment. The latter is also suggested by recent developments concerning the influence (or lack thereof) of scientists on daily life and politics. The paper touches on several fundamental issues in the history of science as a discipline that have been or are still being intensely debated.
The Mediterranean realm, comprising the Mediterranean and Macaronesian regions, has long been recognized as one of the world’s biodiversity hotspots, owing to its remarkable species richness and endemism. Several hypotheses on biotic and abiotic drivers of species diversification in the region have been often proposed but rarely tested in an explicit phylogenetic framework. Here, we investigate the impact of both species-intrinsic and -extrinsic factors on diversification in the species-rich, cosmopolitan Limonium, an angiosperm genus with center of diversity in the Mediterranean. First, we infer and time-calibrate the largest Limonium phylogeny to date. We then estimate ancestral ranges and diversification dynamics at both global and regional scales. At the global scale, we test whether the identified shifts in diversification rates are linked to specific geological and/or climatic events in the Mediterranean area and/or asexual reproduction (apomixis). Our results support a late Paleogene origin in the proto-Mediterranean area for Limonium, followed by extensive in situ diversification in the Mediterranean region during the late Miocene, Pliocene, and Pleistocene. We found significant increases of diversification rates in the “Mediterranean lineage” associated with the Messinian Salinity Crisis, onset of Mediterranean climate, Plio-Pleistocene sea-level fluctuations, and apomixis. Additionally, the Euro-Mediterranean area acted as the major source of species dispersals to the surrounding areas. At the regional scale, we infer the biogeographic origins of insular endemics in the oceanic archipelagos of Macaronesia, and test whether woodiness in the Canarian Nobiles clade is a derived trait linked to insular life and a biotic driver of diversification. We find that Limonium species diversity on the Canary Islands and Cape Verde archipelagos is the product of multiple colonization events followed by in situ diversification, and that woodiness of the Canarian endemics is indeed a derived trait but is not associated with a significant shift to higher diversification rates. Our study expands knowledge on how the interaction between abiotic and biotic drivers shape the uneven distribution of species diversity across taxonomic and geographical scales.
Chronic myeloid leukemia (CML) has been a “model disease” with a long history. Beginning with the first discovery of leukemia and the description of the Philadelphia Chromosome and ending with the current goal of achieving treatment-free remission after targeted therapies, we describe here the journey of CML, focusing on molecular pathways relating to signaling, metabolism and the bone marrow microenvironment. We highlight current strategies for combination therapies aimed at eradicating the CML stem cell; hopefully the final destination of this long voyage.
Long non-coding RNA aerrie controls DNA damage repair via YBX1 to maintain endothelial cell function
(2021)
Aging is accompanied by many physiological changes. These changes can progressively lead to many types of cardiovascular diseases. During this process blood vessels lose their ability to maintain vascular homeostasis, ultimately resulting in hypertension, stroke, or myocardial infarction. Increase in DNA damage is one of the hallmarks of aging and can be repaired by the DNA signaling and repair system. In our study we show that long non-coding RNA Aerrie (linc01013) contributes to the DNA signaling and repair mechanism. Silencing of Aerrie in endothelial cells impairs angiogenesis, migration, and barrier function. Aerrie associates with YBX1 and together they act as important factors in DNA damage signaling and repair. This study identifies Aerrie as a novel factor in genomic stability and as a binding partner of YBX1 in responding to DNA damage.
This article provides a comprehensive overview of the contribution of linguistic research on Portuguese as a heritage language in Germany to the general understanding of heritage language development. From 1955 to 1973, nearly 166,000 Portuguese migrants found work in Germany as so-called ‘guest workers’ (Gastarbeiter). Because the aim of many Portuguese migrant families was to return to Portugal, their children met relatively good conditions for the acquisition of their heritage language. Nonetheless, second-generation heritage speakers (HSs) show some linguistic particularities in comparison to monolingual Portuguese speakers in Portugal. Based on the results of previous research, we show that the following factors shape the linguistic knowledge of this group of bilinguals: (1) Restricted exposure to the heritage language may cause a delay in the development of certain linguistic structures, (2) deviations from the standard norm may be related to the lack of formal education and the primacy of the colloquial register and (3) heritage bilinguals may accelerate ongoing diachronic development. We argue that apparent effects of influence from the environmental language can often have alternative explanations.
Repeated search studies are a hallmark in the investigation of the interplay between memory and attention. Due to a usually employed averaging, a substantial decrease in response times occurring between the first and second search through the same search environment is rarely discussed. This search initiation effect is often the most dramatic decrease in search times in a series of sequential searches. The nature of this initial lack of search efficiency has thus far remained unexplored. We tested the hypothesis that the activation of spatial priors leads to this search efficiency profile. Before searching repeatedly through scenes in VR, participants either (1) previewed the scene, (2) saw an interrupted preview, or (3) started searching immediately. The search initiation effect was present in the latter condition but in neither of the preview conditions. Eye movement metrics revealed that the locus of this effect lies in search guidance instead of search initiation or decision time, and was beyond effects of object learning or incidental memory. Our study suggests that upon visual processing of an environment, a process of activating spatial priors to enable orientation is initiated, which takes a toll on search time at first, but once activated it can be used to guide subsequent searches.
Astrocytes contribute to many higher brain functions. A key mechanism in glia-to-neuron signalling is vesicular exocytosis; however, the identity of exocytosis organelles remains a matter of debate. Since vesicles derived from the trans-Golgi network (TGN) are not considered in this context, we studied the astrocyte TGN by immunocytochemistry applying anti-Rab6A. In mouse brain, Rab6A immunostaining is found to be unexpectedly massive, diffuse in all regions, and is detected preferentially and abundantly in the peripheral astrocyte processes, which is hardly evident without glial fibrillary acid protein (GFAP) co-staining. All cells positive for the astrocytic markers glutamine synthetase (GS), GFAP, aldehyde dehydrogenase 1 family member L1 (Aldh1L1), or SRY (sex determining region Y)-box 9 (SOX9) were Rab6A+. Rab6A is excluded from microglia, oligodendrocytes, and NG2 cells using cell type-specific markers. In human cortex, Rab6A labelling is very similar and associated with GFAP+ astrocytes. The mouse data also confirm the specific astrocytic labelling by Aldh1L1 or SOX9; the astrocyte-specific labelling by GS sometimes debated is replicated again. In mouse and human brain, individual astrocytes display high variability in Rab6A+ structures, suggesting dynamic regulation of the glial TGN. In summary, Rab6A expression is an additional, global descriptor of astrocyte identity. Rab6A might constitute an organelle system with a potential role of Rab6A in neuropathological and physiological processes.
PKCζ and PKCι/λ form the atypical protein kinase C subgroup, characterised by a lack of regulation by calcium and the neutral lipid diacylglycerol. To better understand the regulation of these kinases, we systematically explored their interactions with various purified phospholipids using the lipid overlay assays, followed by kinase activity assays to evaluate the lipid effects on their enzymatic activity. We observed that both PKCζ and PKCι interact with phosphatidic acid and phosphatidylserine. Conversely, PKCι is unique in binding also to phosphatidylinositol-monophosphates (e.g., phosphatidylinositol 3-phosphate, 4-phosphate, and 5-phosphate). Moreover, we observed that phosphatidylinositol 4-phosphate specifically activates PKCι, while both isoforms are responsive to phosphatidic acid and phosphatidylserine. Overall, our results suggest that atypical Protein kinase C (PKC) localisation and activity are regulated by membrane lipids distinct from those involved in conventional PKCs and unveil a specific regulation of PKCι by phosphatidylinositol-monophosphates.
Objective: In light of the ongoing COVID-19 pandemic and the associated hospitalization of an overwhelming number of ventilator-dependent patients, medical and/or ethical patient triage paradigms have become essential. While guidelines on the allocation of scarce resources do exist, such work within the subdisciplines of intensive care (e.g., neurocritical care) remains limited.
Methods: A 16-item questionnaire was developed that sought to explore/quantify the expert opinions of German neurointensivists with regard to triage decisions. The anonymous survey was conducted via a web-based platform and in total, 96 members of the Initiative of German Neurointensive Trial Engagement (IGNITE)-study group were contacted via e-mail. The IGNITE consortium consists of an interdisciplinary panel of specialists with expertise in neuro-critical care (i.e., anesthetists, neurologists and neurosurgeons).
Results: Fifty members of the IGNITE consortium responded to the questionnaire; in total the respondents were in charge of more than 500 Neuro ICU beds throughout Germany. Common determinants reported which affected triage decisions included known patient wishes (98%), the state of health before admission (96%), SOFA-score (85%) and patient age (69%). Interestingly, other principles of allocation, such as a treatment of “youngest first” (61%) and members of the healthcare sector (50%) were also noted. While these were the most accepted parameters affecting the triage of patients, a “first-come, first-served” principle appeared to be more accepted than a lottery for the allocation of ICU beds which contradicts much of what has been reported within the literature. The respondents also felt that at least one neurointensivist should serve on any interdisciplinary triage team.
Conclusions: The data gathered in the context of this survey reveal the estimation/perception of triage algorithms among neurointensive care specialists facing COVID-19. Further, it is apparent that German neurointensivists strongly feel that they should be involved in any triage decisions at an institutional level given the unique resources needed to treat patients within the Neuro ICU.
“Right to Buy” (RTB), a large-scale natural experiment by which incumbent tenants in public housing could buy properties at heavily-subsidised prices, increased the UK homeownership rate by over 10 percentage points between 1980 and the late 1990s. This paper studies its impact on crime, showing that RTB generated significant reductions in property and violent crime that persist up to today. The behavioural changes of incumbent tenants and the renovation of public properties were the main drivers of the crime reduction. This is evidence of a novel means by which subsidised homeownership and housing policy may contribute to reduce criminality.
Functional coupling of Slack channels and P2X3 receptors contributes to neuropathic pain processing
(2021)
The sodium-activated potassium channel Slack (KNa1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the sodium-activated potassium current (IKNa) and modulates neuronal activity. Previous studies suggest that Slack is involved in the processing of neuropathic pain. However, mechanisms underlying the regulation of Slack activity in this context are poorly understood. Using whole-cell patch-clamp recordings we found that Slack-mediated IKNa in sensory neurons of mice is reduced after peripheral nerve injury, thereby contributing to neuropathic pain hypersensitivity. Interestingly, Slack is closely associated with ATP-sensitive P2X3 receptors in a population of sensory neurons. In vitro experiments revealed that Slack-mediated IKNa may be bidirectionally modulated in response to P2X3 activation. Moreover, mice lacking Slack show altered nocifensive responses to P2X3 stimulation. Our study identifies P2X3/Slack signaling as a mechanism contributing to hypersensitivity after peripheral nerve injury and proposes a potential novel strategy for treatment of neuropathic pain.