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Editorial [2020, english]
(2020)
Combining cultural history with the insights of psychoanalytic theory, this article examines Maurice Sendak's Caldecott-winning and controversial Where the Wild Things Are (1963), arguing that Sendak’s book represents picturebook psychology as it stood in the early 1960s but also radically recasts it, paving the way for a groundswell in applied picturebook psychology. The book can be understood as rewriting classical Freudian analysis, retaining some of its rigor and edge while making it more palatably American. Where the Wild Things Are has been embraced as a psychological primer, a story about anger and its management through fantasy; it is also a text in which echoes of Freud remain audible. It is read it here as a bedtime-story version of Freud’s Wolf Man case history of 1918, an updated and upbeat dream of the wolf boy. It is to Sendak what the Wolf Man case was to Freud, a career-making feral tale. Standing at the crossroads of Freudian tradition, child analysis, humanistic psychology, and bibliotherapy, the article reveals how the book both clarified and expanded the uses of picturebook enchantment.
Die Phänomene des Traums und Träumens als allnächtliche Konfrontation mit dem Fremden und Anderen des wachen (Er-)Lebens (vgl. Engel 2003, S. 153) wie auch der wachen Persönlichkeit üben eine nachhaltige Faszination aus, die maßgeblich auf ihre ambivalente Charakteristik zurückzuführen ist. Der/die Träumende befindet sich in einem Stadium jenseits der Realität, in einem Dazwischen von Leben und Tod, und ist »mit einer Erlebenswelt und einer Erlebensweise konfrontiert, die [Manfred Engel zufolge] auf ebenso evidente wie rätselhafte Weise anders sind als die des wachen Lebens« (ebd.)...
"Die Träume gehören zweifellos zur Wirklichkeit" : Traum-Erzählungen über Kindheit und für Kinder
(2020)
Theodor Storms Kindermärchen Der kleine Häwelmann, von dem Autor 1849 für seinen Sohn Hans verfasst und 1850 veröffentlicht, ist in seiner moralisch-komischen Form ein exemplarisches Exponat der Kinderliteratur des 19. Jahrhunderts. Gemäß der biedermeierlich gestimmten, belehrenden Funktion des Textes steht kindliche Allmachtsfantasie im Mittelpunkt des Geschehens. Die Haltung des ›Mehr-mehr‹ überschreitet indes die Grenzen der Moralerzählung. Entgegen der abschreckenden Funktion scheint vielmehr der kleine Häwelmann in der Verschränkung von Norm-Übertritt und Eskapismus ein ›modernes‹ Kind seiner Entstehungszeit zu sein und durchaus mit den Figuren des Struwwelpeters vergleichbar, die der Arzt und Kinderpsychiater Heinrich Hoffmann 1845 entworfen hat...
Editorial [2020, deutsch]
(2020)
Klingelhöfer, Doris ; Braun, Markus ; Seeger-Zybok, Rebekka ; Quarcoo, David ; Brüggmann, Dörthe ; Groneberg, Jan David Alexander
Background: Fabry disease (FD), the second most prevalent lysosomal storage disorder, is classified as a rare disease. It often leads to significant quality of life impairments and premature death. Many cases remain undiagnosed due to the rarity and heterogeneity. Further, costs related to treatment often constitute a substantial financial burden for patients and health systems. While its epidemiology is still unclear, newborn screenings suggest that its actual prevalence rate is significantly higher than previously suspected. Methods: Based on well-established methodologies, this study gives an overview about the background of the development of FD-related research and provides a critical view of future needs. Results: On the grounds of benchmarking findings, an increasing research activity on FD can be observed. Most publishing countries are the USA, some European countries, Japan, Taiwan, and South Korea. In general, high-income countries publish comparably more on FD than low- or middle-income economies. The countries' financial and infrastructural background are unveiled as crucial factors for the FD research activity. Conclusions: Overall, there is a need to foster FD research infrastructure in developing and emerging countries with focus on cost-intensive genetic research that is independent from economic interests of big pharmaceutical companies.
Lapa, Sriramya ; Claus, Inga ; Reitz, Sarah ; Quick-Weller, Johanna ; Sauer, Sonja ; Colbow, Sigrid ; Nasari, Christiane ; Dziewas, Rainer ; Kang, Jun-Suk ; Baudrexel, Simon ; Warnecke, Tobias
Objective: Deep brain stimulation (DBS) of the ventral intermediate nucleus (VIM) is a mainstay treatment for severe and drug-refractory essential tremor (ET). Although stimulation-induced dysarthria has been extensively described, possible impairment of swallowing has not been systematically investigated yet. Methods: Twelve patients with ET and bilateral VIM-DBS with self-reported dysphagia after VIM-DBS were included. Swallowing function was assessed clinically and using by flexible endoscopic evaluation of swallowing in the stim-ON and in the stim-OFF condition. Presence, severity, and improvement of dysphagia were recorded. Results: During stim-ON, the presence of dysphagia could be objectified in all patients, 42% showing mild, 42% moderate, and 16 % severe dysphagia. During stim-OFF, all patients experienced a statistically significant improvement of swallowing function. Interpretation: VIM-DBS may have an impact on swallowing physiology in ET-patients. Further studies to elucidate the prevalence and underlying pathophysiological mechanisms are warranted.
Global landscapes are changing due to human activities with consequences for both biodiversity and ecosystems. For single species, terrestrial mammal population densities have shown mixed responses to human pressure, with both increasing and decreasing densities reported in the literature. How the impacts of human activities on mammal populations translates into altered global density patterns remains unclear. Here we aim to disentangle the effect of human impacts on large-scale patterns of mammal population densities using a global dataset of 6729 population density estimates for 468 mammal species (representing 59% and 44% of mammalian orders and families). We fitted a mixed effect model to explain the variation in density based on a 1-degree resolution as a function of the human footprint index (HFI), a global proxy of direct and indirect human disturbances, while accounting for body mass, trophic level and primary productivity (normalized vegetation index; NDVI). We found a significant positive relationship between population density and HFI, where population densities were higher in areas with a higher HFI (e.g. agricultural or suburban areas – no populations were located in very high HFI urban areas) compared to areas with a low HFI (e.g. wilderness areas). We also tested the effect of the individual components of the HFI and still found a consistent positive effect. The relationships remained positive even across populations of the same species, although variability among species was high. Our results indicate shifts in mammal population densities in human modified landscapes, which is due to the combined effect of species filtering, increased resources and a possible reduction in competition and predation. Our study provides further evidence that macroecological patterns are being altered by human activities, where some species will benefit from these activities, while others will be negatively impacted or even extirpated.
Strack, Elisabeth ; Rolfe, P. Alexander ; Fink, Annika ; Bankov, Katrin ; Schmid, Tobias ; Solbach, Christine ; Savai, Rajkumar ; Sha, Weixiao ; Pradel, Leon ; Hartmann, Sylvia ; Brüne, Bernhard ; Weigert, Andreas
Background: Breast cancer is the leading cause of cancer-related deaths in women, demanding new treatment options. With the advent of immune checkpoint blockade, immunotherapy emerged as a treatment option. In addition to lymphocytes, tumor-associated macrophages exert a significant, albeit controversial, impact on tumor development. Pro-inflammatory macrophages are thought to hinder, whereas anti-inflammatory macrophages promote tumor growth. However, molecular markers to identify prognostic macrophage populations remain elusive. Methods: We isolated two macrophage subsets, from 48 primary human breast tumors, distinguished by the expression of CD206. Their transcriptomes were analyzed via RNA-Seq, and potential prognostic macrophage markers were validated by PhenOptics in tissue microarrays of patients with invasive breast cancer. Results: Normal human breast tissue contained mainly CD206+ macrophages, while increased relative amounts of CD206− macrophages were observed in tumors. The presence of CD206+ macrophages correlated with a pronounced lymphocyte infiltrate and subsets of CD206+ macrophages, expressing SERPINH1 and collagen 1, or MORC4, were unexpectedly associated with improved survival of breast cancer patients. In contrast, MHCIIhi CD206− macrophages were linked with a poor survival prognosis. Conclusion: Our data highlight the heterogeneity of tumor-infiltrating macrophages and suggest the use of multiple phenotypic markers to predict the impact of macrophage subpopulations on cancer prognosis. We identified novel macrophage markers that correlate with the survival of patients with invasive mammary carcinoma.