Medizin
Refine
Year of publication
Document Type
- Article (3562) (remove)
Has Fulltext
- yes (3562) (remove)
Keywords
- inflammation (47)
- glioblastoma (29)
- apoptosis (27)
- breast cancer (26)
- cancer (26)
- Inflammation (19)
- biomarker (18)
- COVID-19 (17)
- autophagy (17)
- Depression (15)
- immunotherapy (15)
- mitochondria (15)
- Cancer (14)
- Germany (14)
- pain (14)
- Apoptosis (13)
- Breast cancer (13)
- depression (13)
- macrophage (13)
- prevention (13)
- prostate cancer (13)
- reactive oxygen species (13)
- Biomarkers (12)
- Cirrhosis (12)
- HIV (12)
- Mammakarzinom (12)
- Neuroscience (12)
- chemotherapy (12)
- Biomarker (11)
- SARS-CoV-2 (11)
- Stroke (11)
- aging (11)
- cytokines (11)
- diagnosis (11)
- epilepsy (11)
- microRNA (11)
- obesity (11)
- schizophrenia (11)
- Chemotherapy (10)
- Gene expression (10)
- Human behaviour (10)
- Mitochondria (10)
- Research article (10)
- angiogenesis (10)
- attention (10)
- cirrhosis (10)
- glioma (10)
- hypoxia (10)
- multiple sclerosis (10)
- ADHD (9)
- COPD (9)
- Children (9)
- Hemorrhage (9)
- MRI (9)
- Oncology (9)
- Primary care (9)
- Treatment (9)
- cell death (9)
- children (9)
- complications (9)
- human (9)
- invasion (9)
- leukemia (9)
- macrophages (9)
- migration (9)
- neuroblastoma (9)
- proliferation (9)
- quality of life (9)
- surgery (9)
- treatment (9)
- Atrial fibrillation (8)
- Behandlung (8)
- Evaluation (8)
- General practice (8)
- Hepatocellular carcinoma (8)
- Liver diseases (8)
- Metastasen (8)
- NADPH oxidase (8)
- Parkinson’s disease (8)
- Prognosis (8)
- Prävention (8)
- Quality of life (8)
- ROS (8)
- cognition (8)
- data science (8)
- differentiation (8)
- fMRI (8)
- mTOR (8)
- psoriasis (8)
- radiotherapy (8)
- Autophagy (7)
- Blood (7)
- Diagnostic markers (7)
- Drug therapy (7)
- Europe (7)
- HDAC (7)
- Immunotherapy (7)
- Machine learning (7)
- Multimorbidity (7)
- Outcome (7)
- Patients (7)
- Schizophrenia (7)
- Surgery (7)
- Survival (7)
- child (7)
- development (7)
- endothelial cells (7)
- epidemiology (7)
- epigenetics (7)
- hepatitis C virus (7)
- hereditary angioedema (7)
- lung cancer (7)
- macrophage polarization (7)
- medical education (7)
- metabolism (7)
- metastases (7)
- natural killer cells (7)
- proteomics (7)
- sepsis (7)
- Borrelia (6)
- CDK4/6 (6)
- Cancer treatment (6)
- Cardiovascular magnetic resonance (6)
- Death rates (6)
- Diabetes mellitus (6)
- Hepatitis C virus (6)
- Liver transplantation (6)
- Magnetic resonance imaging (6)
- Mental health and psychiatry (6)
- NASH (6)
- PD1/PDL1 (6)
- PI3K (6)
- Pain (6)
- Radiotherapy (6)
- Studien (6)
- Suicide (6)
- Surgical and invasive medical procedures (6)
- TRAIL (6)
- VEGF (6)
- bipolar disorder (6)
- brain metastases (6)
- diffusion tensor imaging (6)
- extracellular matrix (6)
- gender (6)
- infection (6)
- information theory (6)
- innate immunity (6)
- integrins (6)
- medizinische Ausbildung (6)
- metastasis (6)
- miRNA (6)
- microbiome (6)
- monocytes (6)
- mouse (6)
- neurodegeneration (6)
- outcome (6)
- particulate matter (6)
- physical activity (6)
- portal hypertension (6)
- prophylaxis (6)
- safety (6)
- targeted therapy (6)
- therapy (6)
- toxicity (6)
- ubiquitin (6)
- vitamin D (6)
- ACLF (5)
- Acute myeloid leukemia (5)
- Angiogenesis (5)
- Atherosclerosis (5)
- Cell signalling (5)
- Clinical trial (5)
- Crohn’s disease (5)
- DNA methylation (5)
- Diagnosis (5)
- EEG (5)
- EGFR (5)
- Epidemiology (5)
- Experimental models of disease (5)
- HCV (5)
- HIV-1 (5)
- Heart failure (5)
- Histology (5)
- IL-6 (5)
- MEG (5)
- Macrophages (5)
- Malaria (5)
- Medical education (5)
- Molecular biology (5)
- Morbidity (5)
- Mortality (5)
- Multiple sclerosis (5)
- Multivariate analysis (5)
- NKG2D (5)
- Non-small cell lung cancer (5)
- Obesity (5)
- Oral anticoagulation (5)
- PCR (5)
- PD-L1 (5)
- RUCAM (5)
- Smac (5)
- T cell (5)
- T cells (5)
- Targeted therapy (5)
- Trauma (5)
- Viral load (5)
- acute coronary syndrome (5)
- acute-on-chronic liver failure (5)
- adhesion (5)
- aortic stenosis (5)
- asthma (5)
- ataxia telangiectasia (5)
- atherosclerosis (5)
- atrial fibrillation (5)
- bevacizumab (5)
- biomarkers (5)
- cardiac surgery (5)
- cell therapy (5)
- chimeric antigen receptor (5)
- chronic kidney disease (5)
- cochlear implant (5)
- colorectal cancer (5)
- complement (5)
- conduct disorder (5)
- coronavirus (5)
- curcumin (5)
- cytotoxicity (5)
- efficacy (5)
- elderly (5)
- environmental tobacco smoke (5)
- fibrosis (5)
- forensic entomology (5)
- gene therapy (5)
- guideline (5)
- integrin (5)
- liver (5)
- magnetic resonance imaging (5)
- mutual information (5)
- natural killer cell (5)
- ovarian cancer (5)
- p53 (5)
- periodontitis (5)
- plasticity (5)
- polytrauma (5)
- prevalence (5)
- prognosis (5)
- regeneration (5)
- renal cell carcinoma (5)
- resistance (5)
- signal transduction (5)
- sphingosine-1-phosphate (5)
- stroke (5)
- transcranial magnetic stimulation (5)
- trauma (5)
- tumor microenvironment (5)
- valproic acid (5)
- ABCB1 (4)
- ATM (4)
- Age groups (4)
- Anticoagulation (4)
- Aortic valve (4)
- Ascites (4)
- Aspergillus fumigatus (4)
- Attention (4)
- Autism spectrum disorder (4)
- B cells (4)
- Bipolar disorder (4)
- CIK cells (4)
- CRISPR/Cas9 (4)
- Cell biology (4)
- Cell staining (4)
- Cell therapy (4)
- Clinical trials (4)
- Communication (4)
- Consensus (4)
- Cytokines (4)
- DILI (4)
- DNA damage (4)
- Decision making (4)
- Denosumab (4)
- Developmental biology (4)
- Diagnostic medicine (4)
- Diagnostik (4)
- E-Learning (4)
- Emotions (4)
- Epilepsy (4)
- Ewing sarcoma (4)
- Fibrosis (4)
- Flow cytometry (4)
- Gastric cancer (4)
- Gender (4)
- Guidelines (4)
- Hematology (4)
- Hodgkin lymphoma (4)
- Homeostasis (4)
- IAP proteins (4)
- Immunohistochemistry (4)
- Immunology (4)
- Kinematic analysis (4)
- Liver cirrhosis (4)
- MRSA (4)
- MSD (4)
- Mechanisms of disease (4)
- Medizindidaktik (4)
- MicroRNAs (4)
- Molecular medicine (4)
- Mouse models (4)
- NK cell (4)
- NK cells (4)
- NK-92 (4)
- Neonates (4)
- Neutropenia (4)
- NoxO1 (4)
- OSCE (4)
- Osteoporosis (4)
- Outcomes (4)
- Parkinson's disease (4)
- Personalized medicine (4)
- Physicians (4)
- Portal hypertension (4)
- Pregnancy (4)
- Prevention (4)
- Proliferation (4)
- Proteomics (4)
- Psychiatric disorders (4)
- Randomized controlled trial (4)
- Reactive oxygen species (4)
- Risiko (4)
- Roussel Uclaf Causality Assessment Method (4)
- Sepsis (4)
- Sex differences (4)
- Stem cells (4)
- Surgical oncology (4)
- Thrombosis (4)
- Ubiquitination (4)
- Validation (4)
- XIAP (4)
- acute kidney injury (4)
- acute lymphoblastic leukemia (4)
- adjuvant therapy (4)
- adjuvante Therapie (4)
- adolescents (4)
- aggression (4)
- alirocumab (4)
- anaemia (4)
- antibodies (4)
- antioxidants (4)
- bibliometry (4)
- cancer stem cells (4)
- cell biology (4)
- climate change (4)
- clinical trial (4)
- cytomegalovirus (4)
- dementia (4)
- dendritic cells (4)
- dental implants (4)
- direct-acting antivirals (4)
- drug resistance (4)
- early breast cancer (4)
- entropy (4)
- evaluation (4)
- faculty development (4)
- fibroblasts (4)
- frühes Mammakarzinom (4)
- gene expression (4)
- graph theory (4)
- heart failure (4)
- hematopoietic stem cell transplantation (4)
- hepatitis C (4)
- hepatocellular carcinoma (4)
- immune evasion (4)
- liver cirrhosis (4)
- liver transplantation (4)
- management (4)
- melanoma (4)
- meningioma (4)
- metabolic syndrome (4)
- mortality (4)
- p21 (4)
- pancreatic cancer (4)
- peripheral artery disease (4)
- precision medicine (4)
- pregnancy (4)
- proteome (4)
- qualitative research (4)
- radiation (4)
- radical prostatectomy (4)
- rapamycin (4)
- registry (4)
- rhabdomyosarcoma (4)
- risk (4)
- risk factors (4)
- seizure (4)
- smoking (4)
- sphingolipids (4)
- spirochetes (4)
- survival (4)
- transfusion (4)
- trials (4)
- tumor progression (4)
- tumor-associated macrophages (4)
- vector (4)
- working memory (4)
- (surface) partial differential equations (3)
- Acute inflammation (3)
- Adverse events (3)
- Aging (3)
- Allgemeinmedizin (3)
- Alzheimer's disease (3)
- Aortic valve replacement (3)
- Aspergillus (3)
- Attitude (3)
- Autism (3)
- B-cell lymphoma (3)
- BCR/ABL (3)
- BRAF (3)
- Blood pressure (3)
- Blood-brain barrier (3)
- Brain metastasis (3)
- C-reactive protein (3)
- C. elegans (3)
- CXCR3 (3)
- CXCR4 (3)
- Cancer chemotherapy (3)
- Cancer detection and diagnosis (3)
- Cancer genetics (3)
- Cardiac surgery (3)
- Cardiology (3)
- Cardiovascular disease (3)
- Catheter ablation (3)
- Cell proliferation (3)
- Chromatin accessibility (3)
- Citation analysis (3)
- Clinical competence (3)
- Clinical genetics (3)
- Cognition (3)
- Cognitive neuroscience (3)
- Cohort studies (3)
- Colorectal cancer (3)
- Complex I (3)
- Complications (3)
- Conduct disorder (3)
- Cytoskeleton (3)
- DMEK (3)
- DNase1-seq (3)
- DTI (3)
- Data processing (3)
- Data science (3)
- Decorin (3)
- Density equalizing mapping (3)
- Diabetes (3)
- Dopamine (3)
- EEG microstates (3)
- Endoscopy (3)
- Endothelial cells (3)
- European Union (3)
- Everolimus (3)
- Exercise (3)
- Eyes (3)
- FTY720 (3)
- Fingolimod (3)
- Finite Volumes (3)
- Fistula (3)
- Functional clustering (3)
- Genetics (3)
- Genome-wide association studies (3)
- Glioblastoma (3)
- Global health (3)
- HAE (3)
- HBV (3)
- HCC (3)
- HER2/neu (3)
- HNSCC (3)
- HPV (3)
- Heart (3)
- Heart transplantation (3)
- Hereditary angioedema (3)
- Hippocampus (3)
- Hospitals (3)
- Human genetics (3)
- Hypertension (3)
- IAPs (3)
- IBD (3)
- In vitro (3)
- Incidence (3)
- Inflammatory diseases (3)
- Innate immunity (3)
- Intensive care (3)
- Kidney transplantation (3)
- Knees (3)
- Knowledge (3)
- Kommunikation (3)
- LCMV (3)
- Langerhans cell histiocytosis (3)
- Language (3)
- Lehrqualifikation (3)
- Lesions (3)
- Liver fibrosis (3)
- Long non-coding RNAs (3)
- Lumbar spine (3)
- MCAK (3)
- MLL (3)
- Machine-learning (3)
- Mesenchymal stem cells (3)
- Messenger RNA (3)
- Molecular neuroscience (3)
- Morphogenesis (3)
- Motor control (3)
- Mouse (3)
- Musculoskeletal disorder (3)
- Musculoskeletal system (3)
- NF-κB (3)
- Neuroinflammation (3)
- Nivolumab (3)
- Nox4 (3)
- Observational study (3)
- PARK2 (3)
- PDGFRβ (3)
- Patient blood management (3)
- Pediatric patients (3)
- Phosphorylation (3)
- Pneumonia (3)
- Prediction (3)
- Predictive markers (3)
- Prevalence (3)
- Prostate cancer (3)
- Public health (3)
- Quantitative MRI (3)
- RITA (3)
- Radiomics (3)
- Rare diseases (3)
- Reaction time (3)
- Rectal cancer (3)
- Registries (3)
- Regression analysis (3)
- Respiration (3)
- Rheumatoid arthritis (3)
- STAT3 (3)
- Signaling (3)
- Statistical data (3)
- Stereotactic body radiation therapy (3)
- Surgeons (3)
- TKI (3)
- Tacrolimus (3)
- Tissue engineering (3)
- Torque (3)
- Training (3)
- Transcription factors (3)
- Transfusion (3)
- Translational research (3)
- Zika virus (3)
- Zoonosis (3)
- acetaminophen (3)
- adaptation (3)
- ageing (3)
- allogeneic stem cell transplantation (3)
- anal cancer (3)
- animal (3)
- anti-angiogenic therapy (3)
- antiviral (3)
- antiviral therapy (3)
- arteriogenesis (3)
- artificial intelligence (3)
- ascites (3)
- astrocytes (3)
- augmentation (3)
- autism spectrum disorder (3)
- bioinformatics (3)
- blood (3)
- body mass index (3)
- brachytherapy (3)
- breast (3)
- cGMP (3)
- cardiac (3)
- caspase-2 (3)
- caspase-8 (3)
- catheter ablation (3)
- ceramides (3)
- cerebellum (3)
- chemoresistance (3)
- cholesterol (3)
- cisplatin (3)
- clinical benefit (3)
- clinical study (3)
- clock genes (3)
- combination therapy (3)
- computational virology (3)
- connectivity (3)
- cortex (3)
- cortisol (3)
- cystic fibrosis (3)
- cytokine-induced killer cells (3)
- dental profession (3)
- dentate gyrus (3)
- dentist (3)
- diabetes mellitus (3)
- didactic (3)
- doxorubicin (3)
- drug induced liver injury (3)
- echocardiography (3)
- electroencephalography (3)
- electrolytic cleaning (3)
- endocannabinoids (3)
- endoplasmic reticulum (3)
- everolimus (3)
- exercise (3)
- exosomes (3)
- fatigue (3)
- flow cytometry (3)
- focal adhesion (3)
- functional magnetic resonance imaging (3)
- gamma (3)
- gastric cancer (3)
- head and neck cancer (3)
- health-related quality of life (3)
- hematopoietic stem and progenitor cells (3)
- herb induced liver injury (3)
- histology (3)
- histone acetylation (3)
- hyperglycemia (3)
- imaging (3)
- immune reconstitution (3)
- immunity (3)
- immunohistochemistry (3)
- immunology (3)
- impulsivity (3)
- inflammasome (3)
- iron (3)
- irradiation (3)
- leukocytes (3)
- lipocalin-2 (3)
- liver fibrosis (3)
- liver injury (3)
- lyme disease (3)
- lymphoma (3)
- mTORC1 (3)
- machine learning (3)
- mass spectrometry (3)
- massively parallel multigrid solvers (3)
- medical students (3)
- memory (3)
- mesenchymal stromal cells (3)
- mesenchymal stromal/stem cells (3)
- metastatic (3)
- metformin (3)
- miRNAs (3)
- mice (3)
- mitophagy (3)
- mitosis (3)
- molecular mechanisms (3)
- mouse model (3)
- multimorbidity (3)
- mycophenolic acid (3)
- neoadjuvant therapy (3)
- neoplasms (3)
- neuropathic pain (3)
- oncology (3)
- osteoarthritis (3)
- osteoporosis (3)
- oxidative stress (3)
- p47phox (3)
- patient blood management (3)
- perfusion (3)
- periimplantitis (3)
- platelets (3)
- polypharmacy (3)
- predictive coding (3)
- preeclampsia (3)
- primary care (3)
- primary health care (3)
- primary immunodeficiency (3)
- prognostic factors (3)
- prostaglandins (3)
- psoriatic arthritis (3)
- rat (3)
- realistic geometries (3)
- reliability (3)
- remodelling (3)
- renal cell cancer (3)
- renal function (3)
- resting state (3)
- review (3)
- rheumatoid arthritis (3)
- screening (3)
- senescence (3)
- skeletal muscle (3)
- sphingolipid (3)
- sphingosine 1-phosphate (3)
- spinal cord (3)
- stress (3)
- stress response (3)
- tobacco prevention (3)
- transplantation (3)
- tumor growth (3)
- ubiquitination (3)
- ultrasound (3)
- viral dynamics (3)
- working conditions (3)
- wound healing (3)
- 3D spatio-temporal resolved mathematical models (2)
- A/D transition (2)
- ABCC1 (2)
- ABCG2 (2)
- AKI (2)
- ALL (2)
- AML (2)
- AMPK (2)
- ATP-citrate lyase (2)
- Academic medicine (2)
- Access (2)
- Acoustics (2)
- Acute lymphocytic leukaemia (2)
- Addison’s disease (2)
- Adenocarcinoma (2)
- Adipose tissue (2)
- Adipose-derived mesenchymal stem cells (2)
- Adolescents (2)
- Adults (2)
- Alcohol consumption (2)
- Alcoholic liver disease (2)
- Alleles (2)
- Allergic asthma (2)
- Allergy (2)
- Alpelisib (2)
- Alzheimer (2)
- Alzheimer’s disease (2)
- Amblyopia (2)
- Anemia (2)
- Antibodies (2)
- Anticoagulant therapy (2)
- Antiretroviral therapy (2)
- Antiretrovirals (2)
- Antiviral therapy (2)
- Aortic dissection (2)
- Apheresis (2)
- Artificial intelligence (2)
- Asphyxia (2)
- Assessment (2)
- Atezolizumab (2)
- Aurora A (2)
- Austria (2)
- Autopsy (2)
- BCL2 (2)
- BCL6 (2)
- BDNF (2)
- BMC (2)
- BRCA1 (2)
- BRCA2 (2)
- BRD4 (2)
- Babesia divergens (2)
- Babesia microti (2)
- Bacterial infection (2)
- Benefit (2)
- Big Data (2)
- Biochemistry (2)
- Bioinformatics (2)
- Biopsy (2)
- Biosynthetic mesh (2)
- Bladder cancer (2)
- Blood groups (2)
- Body mass index (2)
- Bone defect (2)
- Bone marrow (2)
- Bone marrow-derived mesenchymal stem cells (2)
- Bone regeneration (2)
- Bone tissue engineering (2)
- Brain tumor (2)
- Breast neoplasms (2)
- Breast tumors (2)
- Brustkrebs (2)
- Burden of disease (2)
- C1 inhibitor (2)
- CAD/CAM (2)
- CAR (2)
- CBA (2)
- CC16 (2)
- CD19 (2)
- CD36 (2)
- CDKN1A (2)
- CLP (2)
- CPE (2)
- CT (2)
- CTGF (2)
- CUELA (2)
- CV9202 (2)
- CXCL12 (2)
- Calcium (2)
- Callous-unemotional traits (2)
- Cancer epidemiology (2)
- Cancer genomics (2)
- Cancer models (2)
- Candida (2)
- Cannabidiol (2)
- Cannabis (2)
- Capecitabine (2)
- Capsule endoscopy (2)
- Cardiac hypertrophy (2)
- Cardiac magnetic resonance (2)
- Cardioprotection (2)
- Cardiovascular diseases (2)
- Case management (2)
- Cats (2)
- Causality assessment (2)
- Celiac disease (2)
- Cell binding (2)
- Cell differentiation (2)
- Cell salvage (2)
- Cerebrospinal fluid (2)
- Cesarean section (2)
- Chaperone (2)
- Checkpoint inhibitor (2)
- Chemical biology (2)
- Chemoradiotherapy (2)
- Chronic disease (2)
- Chronic diseases (2)
- Chronic hepatitis (2)
- Chronic kidney disease (2)
- Chronic obstructive pulmonary disease (2)
- Clinical presentation (2)
- Clinical studies (2)
- Clinical study (2)
- Cocaine (2)
- Cognitive behavioral therapy (2)
- Cognitive impairment (2)
- Community based intervention (2)
- Compliance (2)
- Complication management (2)
- Connective tissue (2)
- Coronary heart disease (2)
- Cortex (2)
- Costs (2)
- Croatia (2)
- Crohn's disease (2)
- Crystal structure (2)
- CspZ (2)
- Cuela (2)
- CyberKnife robotic radiosurgery (2)
- Cytogenetics (2)
- Cytoskeletal proteins (2)
- DAA (2)
- DMARDs (biologic) (2)
- DNA damage response (2)
- DNA mismatch repair (2)
- DSM (2)
- Daptomycin (2)
- Data visualization (2)
- Decision (2)
- Decision trees (2)
- Dentist (2)
- Dentistry (2)
- Deutschland (2)
- Diagnose (2)
- Diagnostics (2)
- Differentiation (2)
- Digestive system procedures (2)
- Direct current electrical stimulation (2)
- Disease Activity (2)
- Docetaxel (2)
- Dose response (2)
- Dravet syndrome (2)
- Drug development (2)
- Drug resistance (2)
- E3 ligase (2)
- ECMO (2)
- EEG-fMRI (2)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (2)
- EQ-5D (2)
- Ears (2)
- Eccentric fixation (2)
- Education (2)
- Efficiency (2)
- Ejection fraction (2)
- Elderly (2)
- Electroencephalography (2)
- Emotion regulation (2)
- EndMT (2)
- Endothelial permeability (2)
- Ensemble learning (2)
- Enzyme-linked immunoassays (2)
- Epidermal growth factor receptor (2)
- Epigenetics (2)
- Epstein-Barr virus (2)
- Ergonomics (2)
- Etiology (2)
- Evidence-based medicine (2)
- Extended donor criteria (2)
- Extracellular matrix (2)
- Eye movements (2)
- Face (2)
- Family practice (2)
- Fatty liver (2)
- Fibroblasts (2)
- Flaps (2)
- Forensic entomology (2)
- Fortbildung (2)
- Frailty (2)
- Früherkennung (2)
- Frühgeburt (2)
- Functional magnetic resonance imaging (2)
- Funding (2)
- G-CSF (2)
- GFAP (2)
- GWAS (2)
- Gadobutrol (2)
- Galaktografie (2)
- Galaktomosynthese (2)
- Gene regulation (2)
- Gene therapy (2)
- General practitioners (2)
- Genetic testing (2)
- Genetics research (2)
- German people (2)
- Glucose metabolism (2)
- Grafts (2)
- Growth factors (2)
- HDACi (2)
- HER2 (2)
- HOD (2)
- HSCT (2)
- HSV (2)
- Head and neck cancer (2)
- Health economics (2)
- Health services research (2)
- Healthcare worker (2)
- Hematologic malignancies (2)
- HepG2 (2)
- Hepatocytes (2)
- Herb induced liver injury (2)
- High-density lipoprotein (2)
- Hirnforschung (2)
- Holmes tremor (2)
- Hypoxia (2)
- ICU (2)
- IHC (2)
- IL-10 (2)
- IL-1β (2)
- IR-A (2)
- Image analysis (2)
- Immune suppression (2)
- Implementation (2)
- Incisional hernia (2)
- Indirect-binding (2)
- Infection (2)
- Infection control (2)
- Infectious diseases (2)
- Inflammatory bowel disease (2)
- Intensive care units (2)
- Interdisciplinarity (2)
- Interleukin-22 (2)
- Interleukin-6 (2)
- Internet (2)
- Iron deficiency anemia (2)
- Ischemia (2)
- Ischemia/reperfusion injury (2)
- Jaw (2)
- KGF (2)
- Katherine (2)
- Klebsiella pneumoniae (2)
- Klinische Kompetenz (2)
- Kompetenzen (2)
- L2 (2)
- LPS (2)
- LVAD (2)
- Labor and delivery (2)
- Left hemisphere (2)
- Legs (2)
- Leukemias (2)
- Linear regression analysis (2)
- Lipid signalling (2)
- Liver Transplantation (2)
- Lokalrezidiv (2)
- Long-term care (2)
- Longitudinal (2)
- Low back pain (2)
- Luciferase (2)
- Lyme disease (2)
- Lymph nodes (2)
- Lymphocytes (2)
- Lysosome (2)
- MALAT1 (2)
- MCAO (2)
- MCI (2)
- MICA (2)
- MMP9 (2)
- MRT (2)
- MYC (2)
- Macroautophagy (2)
- Mamma (2)
- Markovianity (2)
- Masquelet technique (2)
- Mass spectrometry (2)
- Maxillary sinus (2)
- Medical risk factors (2)
- Medication Appropriateness Index (2)
- Medicine (2)
- Medizinstudium (2)
- Meldepflicht (2)
- Membrane potential (2)
- Mesh (2)
- Metastatic breast cancer (2)
- Microbiome (2)
- Microsurgery (2)
- Migrants (2)
- Minimal residual disease (2)
- Mitosis (2)
- MitraClip (2)
- Mixed methods (2)
- Molecular profiling (2)
- Morphometry (2)
- Multidrug resistance (2)
- Multiple chronic conditions (2)
- Musculoskeletal diseases (2)
- Mutation (2)
- Myocardial infarction (2)
- NADH:ubiquinone oxidoreductase (2)
- NAFLD (2)
- NK cells (2)
- NOTCH1 (2)
- Nachsorge (2)
- Neoplasms (2)
- Nepal (2)
- Nerve fibers (2)
- Nerve regeneration (2)
- Neural circuits (2)
- Neuroimaging (2)
- Neurology (2)
- Neuronal morphology (2)
- Neurons (2)
- Nevirapine (2)
- Next-generation sequencing (2)
- Nitric oxide (2)
- Non-REM sleep (2)
- Non-interventional study (2)
- Normal distribution (2)
- Nox (2)
- Nox1 (2)
- Nrf2 (2)
- OSPE (2)
- Occlusion treatment (2)
- Operation/Chirurgie (2)
- Ophthalmology (2)
- Optogenetics (2)
- Oral surgery (2)
- Organ dysfunction (2)
- Organ dysfunctions (2)
- Oroantral (2)
- Osteogenic differentiation (2)
- Outcome assessment (2)
- Ovarian cancer (2)
- Oxidative stress (2)
- P600 (2)
- PARP (2)
- PD1/ PDL1 (2)
- PD‑L1 (2)
- PET (2)
- PINK1 (2)
- Palliative care (2)
- Palliative care [MeSH] (2)
- Parkin (2)
- Parkinson disease (2)
- Patient-centred care (2)
- Pediatric (2)
- Pediatric infections (2)
- Percutaneous coronary intervention (2)
- Periodontitis (2)
- Peritonitis (2)
- Persistence (2)
- Personal- und Organisationsentwicklung (2)
- Philadelphia chromosome (2)
- Phylogenetic analysis (2)
- Physiology (2)
- Plasmodium (2)
- Platelet-rich fibrin (2)
- Platelets (2)
- Plerixafor (2)
- Plk1 inhibitors (2)
- Podospora anserina (2)
- Polypharmacy (2)
- Portal veins (2)
- Post-translational modifications (2)
- Postoperative radiochemotherapy (2)
- Postural control (2)
- Practical skills (2)
- Professionalisierung (2)
- Prognosefaktoren (2)
- Prognostic (2)
- Prognostic markers (2)
- Programm (2)
- Progranulin (2)
- Prophylaxis (2)
- Prostatic neoplasms (2)
- Protease inhibitor therapy (2)
- Proteasome (2)
- Protein translation (2)
- Prädiktivfaktoren (2)
- Psychology (2)
- Pulmonary hypertension (2)
- Pulmonary veins (2)
- Quality of care (2)
- Questionnaires (2)
- RIPK3 (2)
- RNA binding proteins (2)
- RNA interference (2)
- RNA interference (RNAi) (2)
- RNA isolation (2)
- Red blood cell transfusion (2)
- Regeneration (2)
- Register (2)
- Registry (2)
- Reliabilität (2)
- Renal cell carcinoma (2)
- Renal system (2)
- Research architecture (2)
- Respiratory chain (2)
- Rhabdomyosarcoma (2)
- Rheumatoid Arthritis (2)
- Richtlinie (2)
- Roussel Uclaf Causality Assessment Method (RUCAM) (2)
- S1P (2)
- SARS (2)
- SARS‐CoV‐2 (2)
- SD-OCT (2)
- SKAP1 (2)
- SPTAN1 (2)
- STING (2)
- Safety (2)
- Sarcoidosis (2)
- Sarcoma (2)
- Schmerz (2)
- Scientists (2)
- Screening (2)
- Senescence (2)
- Sensory processing (2)
- Sestrin 2 (2)
- Simulated patients (2)
- Skills (2)
- Sleep (2)
- Social participation (2)
- Socioeconomic status (2)
- Sorafenib (2)
- Sphingolipids (2)
- Sports and exercise medicine (2)
- Staff development (2)
- Stem cell (2)
- Stem-cell therapies (2)
- Strength training (2)
- Streptococcus pneumoniae (2)
- Structural plasticity (2)
- Study protocol (2)
- Subarachnoid hemorrhage (2)
- Sunitinib (2)
- Superoxide (2)
- Supportivtherapie (2)
- Survival analysis (2)
- Survivin (2)
- Sweden (2)
- Synaptic plasticity (2)
- Systematic reviews (2)
- TBSS (2)
- TF-complexes (2)
- TGFβ (2)
- Target identification (2)
- Teeth (2)
- Tele-EEG (2)
- Tenofovir (2)
- Thailand (2)
- Therapie (2)
- Therapy (2)
- Thermoregulation (2)
- Thoracic trauma (2)
- Thromboembolism (2)
- Thrombolysis (2)
- Toll-like receptor (2)
- Tomosynthese (2)
- Toxicity (2)
- Transarterial chemoembolization (2)
- Transcription Factors (2)
- Transmission (2)
- Traumatic injury (2)
- Treatment outcome (2)
- Tumor microenvironment (2)
- T‑DM1 (2)
- Ulcerative colitis (2)
- Ultraschall (2)
- Ultrasonography (2)
- Ultrasound (2)
- Urology (2)
- VDR (2)
- VIGALL (2)
- Vaccination (2)
- Validität (2)
- Vascularization (2)
- Veins (2)
- Video (2)
- Vision (2)
- Visual acuity (2)
- Vitamin D (2)
- Vitamin D deficiency (2)
- Vmem (2)
- Warburg effect (2)
- Working memory (2)
- Wound healing (2)
- Wundheilung (2)
- abuse (2)
- acetyl-CoA (2)
- acute decompensation (2)
- acute lung injury (2)
- acute myeloid leukaemia (2)
- acute myeloid leukemia (2)
- adalimumab (2)
- additives (2)
- adenosine (2)
- adenovirus (2)
- adherence (2)
- adipose-derived mesenchymal stem cells (2)
- admission test (2)
- adoptive cancer immunotherapy (2)
- advanced (2)
- advanced care planning (2)
- adverse reaction (2)
- age (2)
- age-related macular degeneration (2)
- aged (2)
- air flow (2)
- albumin (2)
- alcohol (2)
- alpelisib (2)
- alveolar ridge augmentation (2)
- analgesics (2)
- animal experiment (2)
- animal models (2)
- antibacterial activity (2)
- antibiotic therapy (2)
- anticonvulsants (2)
- antiepileptic drugs (2)
- antisocial behavior (2)
- arousal (2)
- arthritis (2)
- astrocytoma (2)
- atezolizumab (2)
- audiovisual (2)
- autoimmune diabetes (2)
- autoimmune disease (2)
- autoimmunity (2)
- autologous stem cell transplantation (2)
- behavior (2)
- betulinic acid (2)
- biocompatibility (2)
- biologics (2)
- biopsy (2)
- blood flow restriction (2)
- bone healing (2)
- bone metabolism (2)
- borrelia (2)
- brain imaging (2)
- brain states (2)
- brain-derived neurotrophic factor (2)
- brainstem (2)
- burden of illness (2)
- cAMP (2)
- cART (2)
- calcitriol (2)
- calretinin (2)
- cancer immunotherapy (2)
- capsaicin (2)
- carbapenemase (2)
- carbapenemases (2)
- cardiovascular (2)
- cardiovascular disease (2)
- case-referent study (2)
- cell migration (2)
- cell motility (2)
- cell proliferation (2)
- cells (2)
- ceramide (2)
- cerebrospinal fluid (2)
- cervical cancer (2)
- chemokines (2)
- chemoradiotherapy (2)
- chemotherapy resistance (2)
- chest trauma (2)
- chronic myeloid leukemia (2)
- chronic thromboembolic pulmonary hypertension (2)
- cigarette (2)
- circadian (2)
- circadian rhythm (2)
- circadian rhythms (2)
- cisplatin resistance (2)
- citation (2)
- classical Hodgkin lymphoma (2)
- cleaning (2)
- clinical research (2)
- clinical studies (2)
- cochlea (2)
- collagen (2)
- colon cancer (2)
- colon carcinoma cells (2)
- colorectal carcinoma (2)
- communication (2)
- complementary and alternative medicine (2)
- complex I (2)
- compliance (2)
- computed tomography (2)
- continuous performance test (2)
- corneal edema (2)
- corneal transplantation (2)
- coronary artery bypass graft surgery (2)
- coronary artery disease (2)
- critical care (2)
- criticality (2)
- cryoballoon (2)
- cyclooxygenase (2)
- cyclosporin A (2)
- cytochrome P450 2E1 (2)
- cytotoxic T cells (2)
- dabrafenib (2)
- deafness (2)
- decision making (2)
- decompensated liver cirrhosis (2)
- dental assistants (2)
- dental education (2)
- dental implant (2)
- dentists (2)
- detoxification (2)
- diabetes (2)
- dietary supplements (2)
- dihydroceramide (2)
- disease models (2)
- disintegration (2)
- distress (2)
- drug discovery (2)
- drug release (2)
- drug-induced liver injury (2)
- dual task (2)
- e-Learning (2)
- eLearning (2)
- education (2)
- eicosanoids (2)
- elderly patients (2)
- electrocardiography (2)
- electron transport chain (2)
- encoding (2)
- endothelial (2)
- endothelial cell (2)
- entorhinal cortex lesion (2)
- epigenetic (2)
- epileptogenesis (2)
- esophageal cancer (2)
- event-related potentials (2)
- expertise (2)
- extraversion (2)
- factor H (2)
- fasting (2)
- feedback (2)
- femoral artery ligation (2)
- fenfluramine (2)
- follow‑up (2)
- fortgeschritten (2)
- fracture (2)
- functional connectivity (2)
- functional genetics (2)
- functional genomics (2)
- gait analysis (2)
- galactography (2)
- galactomosynthesis (2)
- gene regulation (2)
- general practice (2)
- genetics (2)
- glucose metabolism (2)
- growth (2)
- growth factor (2)
- growth inhibition (2)
- guidelines (2)
- health (2)
- health information exchange (2)
- heart rate (2)
- hedgehog signaling (2)
- hematopoiesis (2)
- hematopoietic stem cells (2)
- hemodialysis (2)
- hemolysis (2)
- hepatic encephalopathy (2)
- hepatitis B (2)
- hepatitis C virus (HCV) (2)
- herbal hepatotoxicity (2)
- hippocampus (2)
- histological validation (2)
- histone deacetylase inhibitor (2)
- human biology and medicine (2)
- human cytomegalovirus (2)
- hyperactivity (2)
- hyperhomocysteinemia (2)
- iDILI (2)
- iPS (2)
- immune escape (2)
- immune response (2)
- immune system (2)
- immunocytochemistry (2)
- in vitro (2)
- induced membrane (2)
- inertial motion capture (2)
- infiltration (2)
- inflammatory bowel disease (2)
- inner ear (2)
- insulin resistance (2)
- integration (2)
- interferon (2)
- interferon gamma (2)
- interleukin-18 (2)
- interleukin-22 (2)
- interleukin-4 (2)
- interleukins (2)
- invasive fungal disease (2)
- invasive fungal infection (2)
- job-exposure matrix (2)
- kidney (2)
- kidney transplantation (2)
- kinase inhibitor (2)
- kinase regulation (2)
- kinematics (2)
- klinischer Nutzen (2)
- knowledge discovery (2)
- lapatinib (2)
- leukopenia (2)
- levetiracetam (2)
- lipoxygenase (2)
- liver disease (2)
- liver metastases (2)
- lncRNA (2)
- local control (2)
- local information dynamics (2)
- local recurrence (2)
- long-term prophylaxis (2)
- long-term survival (2)
- longevity (2)
- lung function (2)
- machine-learning (2)
- magnetoencephalography (2)
- maintenance (2)
- mandatory reporting (2)
- marginal bone loss (2)
- mathematical modeling (2)
- mathematical models of viral RNA cycle (2)
- matrix (2)
- medical studies (2)
- melatonin (2)
- metabolomics (2)
- methylprednisolone (2)
- microdosing (2)
- microenvironment (2)
- microglia (2)
- microwave ablation (2)
- mild cognitive impairment (2)
- minimalinvasive Biopsie (2)
- minimally invasive biopsies (2)
- mitochondrial disease (2)
- modeling (2)
- modularity (2)
- molecular mimicry (2)
- morphogenesis (2)
- motility (2)
- multidrug resistance (2)
- multinucleated giant cells (2)
- musculoskeletal (2)
- musculoskeletal disorders (2)
- music (2)
- myelodysplastic syndrome (2)
- nanoparticles (2)
- natural product (2)
- necroptosis (2)
- neoadjuvant chemotherapy (2)
- neoadjuvante Chemotherapie (2)
- neoadjuvante Therapie (2)
- neonate (2)
- network analysis (2)
- neural network (2)
- neural oscillations (2)
- neurocritical care (2)
- neurogenesis (2)
- neuroimaging (2)
- neuromodulation (2)
- neurophysiology (2)
- neuroticism (2)
- neutrophils (2)
- newborn (2)
- next generation sequencing (2)
- next generation sequencing (NGS) (2)
- nitric oxide (2)
- non-coding RNA (2)
- nursery schools (2)
- nutlin-3 (2)
- observational study (2)
- occupational exposure (2)
- occupational health (2)
- omega-3 fatty acids (2)
- oncogene (2)
- oscillations (2)
- osteogenesis (2)
- outcomes (2)
- overall survival (2)
- overweight (2)
- paclitaxel (2)
- paired associative stimulation (2)
- palatal tremor (2)
- pandemic (2)
- partial information decomposition (2)
- patient (2)
- patient safety (2)
- patient triage (2)
- pelvic packing (2)
- peptide aptamer (PA) (2)
- perception (2)
- perforant path transection (2)
- peri‐implantitis (2)
- phagocytosis (2)
- pharmacodynamics (2)
- pharmacoresistance (2)
- pharmacovigilance (2)
- phosphate (2)
- plasmid (2)
- platelet-rich fibrin (2)
- polo-like kinase 1 (2)
- poly(lactic-co-glycolic acid) (PLGA) (2)
- polygenic risk score (2)
- polymerase chain reaction (2)
- polymorphism (2)
- population dynamics (2)
- postoperative complications (2)
- posttraumatic stress disorder (2)
- predictive factors (2)
- prefrontal cortex (2)
- preterm birth (2)
- primary cilium (2)
- primary sclerosing cholangitis (2)
- prognostic value (2)
- prostaglandin (2)
- proteasome inhibitor (2)
- protein kinase (2)
- protein quality control (2)
- proteoglycan (2)
- proximal tubule (2)
- psychophysiology (2)
- psychosis (2)
- public health (2)
- pulmonary hypertension (2)
- pulmonary vein isolation (2)
- quality (2)
- quality assurance (2)
- quantitative MRI (2)
- questionnaire (2)
- rare diseases (2)
- re-osseointegration (2)
- real-world data (2)
- recommendations (2)
- reference values (2)
- reproducibility (2)
- research (2)
- revision surgery (2)
- ribavirin (2)
- risk prediction (2)
- rituximab (2)
- school-based prevention (2)
- scientometrics (2)
- scientometry (2)
- second-hand smoke (2)
- secretion (2)
- secretome (2)
- secukinumab (2)
- seizures (2)
- sensory neuropathy (2)
- severe acute respiratory syndrome coronavirus 2 (2)
- sex (2)
- sex differences (2)
- short essay questions (2)
- shunt (2)
- siRNA (2)
- signal transducer and activator of transcription 5 (Stat5) (2)
- signaling (2)
- signature (2)
- simulation (2)
- simulation training (2)
- single-sided deafness (2)
- skin (2)
- sleep (2)
- smoking cessation (2)
- soft tissue sarcoma (2)
- soluble MICA (2)
- spiking neural networks (2)
- spreadsheet (2)
- stability (2)
- stationarity (2)
- status epilepticus (2)
- stem cell transplantation (2)
- studies (2)
- sulforaphane (2)
- supportive therapy (2)
- surgical procedures (2)
- survival rate (2)
- survivin (2)
- synchronization (2)
- synchrony (2)
- synergy (2)
- systematic review (2)
- telemedicine (2)
- temozolomide (2)
- temperature (2)
- temporal lobe epilepsy (2)
- temsirolimus (2)
- therapy monitoring (2)
- therapy resistance (2)
- thymus (2)
- tissue Doppler imaging (2)
- tobacco (2)
- tobacco smoke (2)
- tomosynthesis (2)
- training (2)
- transcriptome (2)
- transient elastography (2)
- trastuzumab (2)
- treatment/therapy (2)
- trophoblast (2)
- tumor angiogenesis (2)
- tumor infiltrating lymphocytes (2)
- tumor suppressor (2)
- tumor-infiltrating lymphocytes (2)
- undergraduate medical education (2)
- ustekinumab (2)
- uteroglobin (2)
- vaccination (2)
- vaccine (2)
- validity (2)
- vemurafenib (2)
- vitamin B deficiency (2)
- von Willebrand factor (2)
- weight loss (2)
- within-host viral modelling (2)
- workflow (2)
- zebrafish (2)
- zinc (2)
- (cardiac) surgery (1)
- (novel) brominated flame retardants ((N)BFR) (1)
- 1,2-dichloroethane (1)
- 1,25-Dihydroxyvitamin D (1)
- 14-3-3 gene family (1)
- 15-PGDH (1)
- 16 segment AHA model (1)
- 16S rRNA sequencing (1)
- 16p11.2 (1)
- 17-AAG (1)
- 17‐OH itraconazole (1)
- 19F MR spectroscopy (1)
- 1H MR spectroscopy (1)
- 1α,25(OH)2D3 (1)
- 2-deoxyglucose (2-DG) (1)
- 2-hydroxyglutarate (1)
- 2019-nCoV (1)
- 2‑methoxyestradiol (1)
- 3-hydroxyanthranilic acid (1)
- 32D progenitor cells (1)
- 3Cs technology (1)
- 3D printed cell-free scaffold (1)
- 3D printing (1)
- 3D rapid prototyping (1)
- 3D spatiotemporal resolved mathematical models (1)
- 3D tissue models (1)
- 3years (1)
- 4-1BB (1)
- 4-FA (1)
- 5 lipoxygenase (1)
- 5' UTR (1)
- 5-lipoxygenase (1)
- 6-Schritt-Methode (1)
- 90% or more improvement in baseline Psoriasis Area and Severity Index (1)
- 99mTc-MIBI (1)
- 99mTc-pertechnetate (1)
- A-FFIP (1)
- A-PRF+ (1)
- A2BP1 (1)
- A375 human melanoma cell line (1)
- A375 human melanoma cells (1)
- A549 (1)
- AA-amylodosis (1)
- AB-serum (1)
- ABS (1)
- ABT-737 (1)
- ACE-Bestimmung (1)
- ACE-inhibitor (1)
- ACL (1)
- ACURATE neo (1)
- ADAM-17 (1)
- ADAM10 (1)
- ADAM15 (1)
- ADAMTS-13 (1)
- ADHD differential diagnosis (1)
- AGC kinase (1)
- AICAR (1)
- AIDS (1)
- AIH immunopathogenesis (1)
- AIS (1)
- AJAP1 (1)
- ALF (1)
- ALK gene (1)
- ALK-rearranged NSCLC (1)
- AMD3100 (1)
- AMH (1)
- AML – acute myeloid leukemia (1)
- AMP-activated kinase (1)
- AOSpine (1)
- AOSpine injury score (1)
- APMPPE - acute posterior multifocal placoid pigment epitheliopathy (1)
- APP (1)
- APP processing (1)
- APRI (1)
- ARA (1)
- ARDS (1)
- ARID5B (1)
- ASA404 (1)
- ASAP (1)
- ASCT (1)
- ASD-specific (1)
- ASO (1)
- AT-101 (1)
- ATO (1)
- ATP (1)
- ATXN2 (1)
- AVM hemorrhage (1)
- AZD7762 (1)
- Abatacept (1)
- Abdominal aortic aneurysm (1)
- Abdominal infections (1)
- Abdominal surgery (1)
- Abdominal trauma (1)
- Abdominelles Aortenaneurysma (1)
- Abiraterone acetate (1)
- Abl kinase inhibitors (1)
- Absenteeism (1)
- Academic health centres (1)
- Academics (1)
- Accelerometry (1)
- Accessibility (1)
- Acellular dermis (1)
- Acer platanoides (1)
- Acid ceramiase (1)
- Acquired drug resistance (1)
- Actin (1)
- Actinomycin D (1)
- Action potential (1)
- Activities of daily living (1)
- Activity control (1)
- Acute HIV infection (1)
- Acute Hemiparesis (1)
- Acute Myeloid Leukemia (1)
- Acute Myeloid Leukemia (AML) (1)
- Acute bronchitis (1)
- Acute calcolous cholecystitis (1)
- Acute coronary syndrome (1)
- Acute cough (1)
- Acute decompensation (1)
- Acute heart failure (1)
- Acute hospital (1)
- Acute leukemia (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukaemia (1)
- Acute-on-chronic liver failure (1)
- Adenylyl cyclase (1)
- Adherence (1)
- Adherence junctions (1)
- Adhesion (1)
- Adipose tissue-derived mesenchymal stem cells (1)
- Adjustment of dosage at steady state (1)
- Adjuvant therapies (1)
- Adolescence (1)
- Adult (1)
- Adult T-cell acute lymphoblastic leukemia (1)
- Adult neurogenesis (1)
- Advanced biliary tract cancer (1)
- Advanced breast cancer (1)
- Advanced glycation endproducts (1)
- Adverse drug reaction (1)
- Aedes aegypti (1)
- Aedes albopictus (1)
- Affective disorders (1)
- Africa (1)
- Age (1)
- Age determination by skeleton (1)
- Aggregation (1)
- Aggressive periodontitis (1)
- Agoraphobia (1)
- Agreement (1)
- Air traffic (1)
- Airways (1)
- Akaike information criterion (AIC) (1)
- Akute Leukämie (1)
- Akutes Koronarsyndrom (1)
- Algorithms (1)
- Aliphatic halogenated hydrocarbons (1)
- Alisertib (1)
- All oral (1)
- All-trans retinoic acid (1)
- Allergen immunotherapy (1)
- Allergic rhinitis (1)
- Allergoid (1)
- Allochromatium vinosum (1)
- Allogeneic Stem Cell Transplantation (SCT) (1)
- Allogeneic hematopoietic stem (1)
- Allogeneic stem cell transplantation (1)
- Allograft bone block (1)
- Allosteric inhibition (1)
- Alpha oscillations (1)
- Alpha-synuclein (1)
- Alpha-synuclein deficiency (1)
- Alternative oxidase (1)
- Alveolar ridge augmentation (1)
- Alzheimer’s dementia (1)
- Ambroxol (1)
- Ameloblastoma (1)
- Amino acid analysis (1)
- Aminosäuremetabolismus (1)
- Aminosäuren (1)
- Aminotransferases (1)
- Amizon (1)
- Amygdala (1)
- Amyloid precursor protein (1)
- Amyloid-beta 42 (1)
- Amyotrophic lateral sclerosis (1)
- Anaemia (1)
- Anaesthesia (1)
- Anal cancer (1)
- Anamneseerhebung (1)
- Anaplastic astrocytoma (1)
- Anatomic competence (1)
- Anatomie (1)
- Anatomie und Histologie (1)
- Anatomy (1)
- Andersen-Tawil syndrome (1)
- Andexanet alpha (1)
- Andropogon virginicus (1)
- Anesthesia, Intravenous (1)
- Aneurysm (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Aneurysms (1)
- Angioedema (1)
- Angiogenèse (1)
- Angiography (1)
- Angioplasty (1)
- Angiotensin Converting Enzyme (1)
- Angiotensin-converting enzyme (1)
- Animal wings (1)
- Ankle arthrometer (1)
- Anopheles (1)
- Anosmia (1)
- Antagonist (1)
- Antarctic marine sponges (1)
- Anterior cingulate cortex (1)
- Anterior cruciate ligament reconstruction (1)
- Anti platelet therapy (1)
- Anti-CMV IgG (1)
- Anti-Müller-Hormon (1)
- Anti-TNF (1)
- Anti-tumor immunity (1)
- Antiangiogenesis (1)
- Antibiotic (1)
- Antibiotic generic drugs (1)
- Antibiotic stewardship (1)
- Antibiotic therapy (1)
- Antibiotics (1)
- Antibody isotypes (1)
- Antibody-mediated rejection (1)
- Anticoagulants (1)
- Anticoagulants [MeSH] (1)
- Antidepressant (1)
- Antifungal agents (1)
- Antigen-presenting cells (1)
- Antigens (1)
- Antihormone therapy (1)
- Antimicrobial resistance (1)
- Antimicrobial treatment (1)
- Antiplatelet therapy (1)
- Antireflux surgery (1)
- Antirheumatic agents (1)
- Antithrombotic therapy (1)
- Antivenom (1)
- Antiviral agents (1)
- Antiviral immune response (1)
- Antiviral response (1)
- Anura (1)
- Anxiety (1)
- Aortic Valve Replacement (1)
- Aortic arch replacement (1)
- Aortic debranching (1)
- Aortic stenosis (1)
- Aortic stiffness (1)
- Aortic valve sparing (1)
- Apes (1)
- Apixaban (1)
- Aquaporins (1)
- Arabin pessary (1)
- Arabin-Pessar (1)
- Area deprivation (1)
- Arms (1)
- Aromatase Inhibitors (1)
- Arrhythmia (1)
- Arrhythmia/all (1)
- Artemether-lumefantrine (1)
- Artemisinin-combination-therapy (1)
- Arteriogenesis (1)
- Artesunate (1)
- Arthroscopy (1)
- Asian bush mosquito (1)
- Aspergillosis (1)
- Aspergillus species (1)
- Assay variation (1)
- Assessment of care (1)
- Asthma (1)
- Asthma and allergic disorders (1)
- Astrocytoma grades (1)
- Ataxia (1)
- Ataxia telangiectasia (1)
- Ataxia-telangiectasia (1)
- Atazanavir (1)
- Atelopus carbonerensis (1)
- Atelopus mucubajiensis (1)
- Atelopus tamaense (1)
- Atención centrada en el paciente (1)
- Atrial appendage occlusion (1)
- Atrial function (1)
- Attack (1)
- Attention Deficit Hyperactivity Disorder (1)
- Attention-deficit / hyperactivity disorder (1)
- Atxn2 (1)
- Audio equipment (1)
- Audio signal processing (1)
- Audiology (1)
- Auditory (1)
- Auditory cortex (1)
- Auditory system (1)
- Auric nanoparticles (1)
- Aurora (1)
- Aurora Ax (1)
- Aurora kinase inhibitor (1)
- Australia (1)
- Autism spectrum disorders (1)
- Autistic Behavior (1)
- Autistic disorder (1)
- Auto transfusion (1)
- Autogenous bone block (1)
- Autoimmune encephalomyelitis (1)
- Autoimmunity (1)
- Autologous stem cell transplantation (1)
- Automated Tube Potential Selection (1)
- Automatic Environmental Tobacco Smoke Emitter (1)
- Autonomic nervous system (1)
- Autosomal recessive cutis laxa type 1C (1)
- Awareness (1)
- Axon (1)
- Axons (1)
- Azacitidine (1)
- Azan trichrome stain (1)
- Azathioprine (1)
- Azidothymidine (1)
- B cell malignancies (1)
- B cell precursor acute lymphoblastic leukemia (1)
- B cell receptor (1)
- B cell subpopulations (1)
- B-cell antigen receptor (1)
- B-cell immunology (1)
- B-cell non-Hodgkin lymphoma (1)
- B-cell receptor (1)
- B16 cells (1)
- BAG3 (1)
- BATF3 (1)
- BBB (1)
- BCL-2 (1)
- BCL11b (1)
- BCR signaling (1)
- BCR-ABL (1)
- BCX7353 (1)
- BFIS (1)
- BG-index (1)
- BI1361849 (1)
- BIAM switch assay (1)
- BIAM-switch (1)
- BIRC5 (1)
- BK channel (1)
- BMAC (1)
- BMI (1)
- BMSC (1)
- BNC2 (1)
- BPD (1)
- BPDCN (1)
- BRAF V600E (1)
- BRAF inhibitors (1)
- BRAF mutation (1)
- BRD4-NUT (1)
- BRUCE (1)
- BRVO (1)
- BTC (1)
- BTK (1)
- BV6 (1)
- Babesia venatorum (1)
- Back pain (1)
- Backpropagating action potential (1)
- Bacterial meningitis (1)
- Bacterial pathogenesis (1)
- Bacterial pathogens (1)
- BadA, (1)
- Bag6 (1)
- Ballet (1)
- Bariatric surgery (1)
- Barlow disease (1)
- Bartonella (1)
- Basal Ganglia (1)
- Basel Consensus Statement (1)
- Basler Consensus Statement (1)
- Bathyergidae (1)
- Batten disease (1)
- Bayesian (1)
- Bayesian inference (1)
- Bayesian model (1)
- Bcl-2 (1)
- Bcr-Abl (1)
- Becton Dickinson (1)
- Bee venom allergy (1)
- Behavior (1)
- Behavioral analysis (1)
- Benchmarks (1)
- Benign disorder (1)
- Benign pulmonary diseases (1)
- Benigne Lungenerkrankungen (1)
- Beratung (1)
- Berci needle (1)
- Best practice (1)
- Best-practice model (1)
- Bestimmungsmethoden (1)
- Bevacizumab (1)
- Bewegungsanalyse mit Inertialsensoren (1)
- Bias (1)
- Bibliometric analysis (1)
- Bibliometrics (1)
- Bidirectional genes (1)
- Big Five (1)
- Big data (1)
- Big five (1)
- Biglycan (1)
- Bilateral cochlear implant (1)
- Bildung (1)
- Biliary physiology (1)
- Biliary tree (1)
- Biliary tree stones (1)
- Bilirubin (1)
- Bioactivity-guided fractionation (1)
- Bioavailability prediction (1)
- Biofilm (1)
- Biofluids (1)
- Biological (1)
- Biological Activity (1)
- Biological heart valves (1)
- Biological invasion (1)
- Biological markers (1)
- Biomarkers & Diagnostic Imaging (1)
- Biomechanical analysis (1)
- Biophysical models (1)
- Bioprosthesis (1)
- Biotechnology (1)
- Bipolar (1)
- Birth weight (1)
- Bisphosphonates (1)
- Blended learning curriculum · (1)
- Blended-Learning-Curriculum (1)
- Blended-learning (1)
- Blog (1)
- Blood cells (1)
- Blood loss (1)
- Blood plasma (1)
- Blood transfusion (1)
- Bloodstream infection (1)
- Bloodstream infections (1)
- Blow fly (1)
- Blowflies (1)
- BluePrint (1)
- Blurred vision (1)
- Body limbs (1)
- Body-contouring surgery (1)
- Bologna process (1)
- Bologna-Prozess (1)
- Bone and joint mechanics (1)
- Bone cancer (1)
- Bone marrow aspirate concentrate (1)
- Bone marrow aspiration (1)
- Bone marrow cells (1)
- Bone marrow fibrosis (1)
- Bone marrow mononuclear cells (1)
- Bone metastasis (1)
- Bone strength assessment (1)
- Borrelia Garinii (1)
- Borrelia burgdorferi (1)
- Borrelia miyamotoi (1)
- Bortezomib (1)
- Bottom-up (1)
- Bradykinin (1)
- Brain (1)
- Brain anatomy (1)
- Brain damage (1)
- Brain development (1)
- Brain injury (1)
- Brain ischemia (1)
- Brain repair (1)
- Brain tumors (1)
- BrainNet Europe consortium (1)
- Breast neoplasm (1)
- Breast reconstruction (1)
- Breathing (1)
- Breech delivery (1)
- Bright light therapy (1)
- Brij 35 (1)
- BrijL23 (1)
- Brms (1)
- Bronchial inflammation (1)
- Bronchitis severity scale (1)
- Bronchodilator agents (1)
- Bronchopulmonary dysplasia (1)
- Bufonidae (1)
- Bungarus niger (1)
- Burst (1)
- Bypass liner (1)
- C-clamp (1)
- C-reactive proteins (1)
- C1 esterase inhibitor (human) (1)
- C1-INH (C1 inhibitor, C1-esterase inhibitor) (1)
- C1-esterase inhibitor protein (1)
- C1-inhibitor (1)
- C1-inhibitor deficiency (1)
- C2 domain (1)
- C3M (1)
- C4M (1)
- C5 acylcarnitine (1)
- C57BL/6J mice (1)
- C57BL/6N mice (1)
- C6 ceramide (1)
- CA (1)
- CA1 (1)
- CAKUT (1)
- CAM (1)
- CAR-NK cell (1)
- CAR-T cell (1)
- CAT (1)
- CCL2 (1)
- CCN2 (1)
- CD137 (1)
- CD16 (1)
- CD23 (1)
- CD271 (1)
- CD3 (1)
- CD3/19 depletion (1)
- CD3/CD19 depletion (1)
- CD34 (1)
- CD34 selection (1)
- CD4 binding site (1)
- CD41 (1)
- CD44 (1)
- CD45RA naïve lymphocytes (1)
- CD49d (1)
- CD56 (1)
- CD62P (1)
- CD74 (1)
- CD8 (1)
- CD8+ T cell (1)
- CD8+ T lymphocytes (1)
- CD8+ T-cell mediated tumor suppression (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CD95/Fas receptor (1)
- CDK inhibitor (1)
- CDK4/6 inhibitor (1)
- CDK4/CDK6 (1)
- CDK9 (1)
- CDKN2A (1)
- CEBPE (1)
- CGD (1)
- CGN codon (1)
- CHA2DS2-VASc-score (1)
- CHIP (1)
- CHRNA10 (1)
- CHRNA7 (1)
- CHRNA9 (1)
- CIK cell (1)
- CIOMS (1)
- CLEC-2 (1)
- CMS (1)
- CMVepidemiology (1)
- CNS (1)
- CNS cancer (1)
- CNS toxicity (1)
- CNVs (1)
- CO2-induced forced ventilation (1)
- COBAS Taqman (1)
- COI (1)
- COII (1)
- COMT (1)
- COPD course and therapy (1)
- CPT1A (1)
- CRE-dependent transcription (1)
- CRE-luciferase (1)
- CREB inhibitor (1)
- CRISPR/Cas (1)
- CRISPR/dCas9 (1)
- CRM (1)
- CRM1 (1)
- CRP (1)
- CRT-D (1)
- CRVO (1)
- CSC marker (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CT-guidance (1)
- CT-guided interventions (1)
- CTLA-4 (1)
- CTX (1)
- CUELA system (1)
- CUP (1)
- CVD biomarker (1)
- CVID (1)
- CWS Studiengruppe (1)
- CXCL10 (1)
- CXCL16 (1)
- CY-503 (1)
- CYBA/p22phox (1)
- CYP1A1 (1)
- Ca2+ imaging (1)
- Caco 2 cells/metabolism (1)
- Caco-2 cells (1)
- Caco‐2 cells (1)
- Caffeine (1)
- Calcium signalling (1)
- Calliphoridae (1)
- Calnexin (1)
- Canada (1)
- Cancer Staging (1)
- Cancer detection (1)
- Cancer epigenetics (1)
- Cancer of unknown primary (1)
- Cancer risk factors (1)
- Cancer staging (1)
- Cancer stem cells (1)
- Cancer therapeutic resistance (1)
- Candida spp (1)
- Carbapenem-resistente Gram-negative Bakterien (CRGN) (1)
- Carbapenemasen (1)
- Carbohydrates (1)
- Carbon tetrachloride (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac (1)
- Cardiac Fibrosis (1)
- Cardiac acoustic biomarkers (1)
- Cardiac device therapy (1)
- Cardiac fibroblast (1)
- Cardiac function (1)
- Cardiac masses (1)
- Cardiac monitoring (1)
- Cardiac necroenzymes (1)
- Cardiac output (1)
- Cardiac remodelling (1)
- Cardiac surgery patients (1)
- Cardiac troponin (1)
- CardioMEMS™ HF system (1)
- Cardiogenic shock (1)
- Cardiomyocyte signaling pathways (1)
- Cardiomyopathy (1)
- Cardiopulmonary bypass (1)
- Cardiovascular Magnetic Resonance (CMR) (1)
- Cardiovascular biology (1)
- Cardiovascular epidemiology (1)
- Cardiovascular genetics (1)
- Cardiovascular mortality (1)
- Career promotion (1)
- Careers (1)
- Carrier-bound fibrin sealant (1)
- Cas9 inhibitor (1)
- Case management [MeSH] (1)
- Case report (1)
- Castleman’s disease (1)
- Catch-up validation study (1)
- Causality (1)
- Cause of death (1)
- Cdk1/cyclin B1 (1)
- Cell Adhesion (1)
- Cell adhesion (1)
- Cell cortex (1)
- Cell cultures (1)
- Cell cycle (1)
- Cell distribution (1)
- Cell division (1)
- Cell membranes (1)
- Cell metabolism (1)
- Cell motility (1)
- Cell plasticity (1)
- Cell processing (1)
- Cell-assisted lipotransfer (1)
- Cell-based therapies (1)
- Cell-to-Cell Spread (1)
- Cellular (1)
- Cellular imaging (1)
- Cellular inflammatory response (1)
- Cellular neuroscience (1)
- Cellular stress (1)
- Cellular stress responses (1)
- Cementation (1)
- Center-specific time in therapeutic range (cTTR) (1)
- Central nervous system (1)
- Central nervous system metastases (1)
- Centrifugation (1)
- Ceramic (1)
- Cerasorb (1)
- Cerclage (1)
- Cerebellar ataxia (1)
- Cerebellum (1)
- Cerebral Vasospasm (1)
- Cerebral cortex (1)
- Cerebral ischemia (1)
- Cerebral toxoplasmosis HIV (1)
- Cerebral vasospasm (1)
- Cerebrovascular (1)
- Certification (1)
- Cervical (1)
- Cesarean delivery (1)
- Change Management (1)
- Checkpoint kinase (1)
- Checkpoints (1)
- Chemical company (1)
- Chemical ecology (1)
- Chemical modification (1)
- Chemiluminescence (1)
- Chemobrain (1)
- Chemoembolization (1)
- Chemokine CCL2 (1)
- Chemokines (1)
- Chemoradiation (1)
- Chemorefractory advanced gastric cancer (1)
- Chemosensitivity (1)
- Chest pain unit (1)
- Chikungunya virus (1)
- Child (1)
- Child adiposity (1)
- Children and adolescents (1)
- Chimerism (1)
- Chlorides (1)
- Chloroform (1)
- Cholecystectomy (1)
- Cholesterin (1)
- Cholesterol (1)
- Chondral Lesion (1)
- Chondrocyte (1)
- Chondrocyte signalling (1)
- Chondrocytes (1)
- Chorion (1)
- Chromatin and Epigenetics (1)
- Chromatin conformation (1)
- Chromoendoscopy (1)
- Chromosomal deletion (1)
- Chromosomale Translokation (1)
- Chronic Hepatitis C (1)
- Chronic ankle instability (1)
- Chronic care model (1)
- Chronic conditions (1)
- Chronic depression (1)
- Chronic disease [MeSH] (1)
- Chronic health condition (1)
- Chronic heart failure (1)
- Chronic hepatitis C virus (1)
- Chronic illness (1)
- Chronic infection (1)
- Chronic inflammation (1)
- Chronic intestinal failure (1)
- Chronic medical conditions (1)
- Chronic obstructive airway disease (1)
- Chronic pancreatitis (1)
- Chronic periodontiti (1)
- Chronification (1)
- Chronology of disease (1)
- Cigarettes (1)
- Cinnarizine (1)
- Cinryze® (1)
- Circadian rhythms and sleep (1)
- Circulation (1)
- Cirugía (1)
- Citation (1)
- Citationrate (1)
- Cities (1)
- Classification (1)
- Claudin 5 (1)
- Cleanliness level (1)
- Cleft palate (1)
- Clincial pharmacology (1)
- CliniMACS (1)
- Clinical Global Impression of Change (1)
- Clinical Skills (1)
- Clinical Trials and Observations (1)
- Clinical effectiveness (1)
- Clinical frailty scale (1)
- Clinical outcome (1)
- Clinical pathways (1)
- Clinical psychometry (1)
- Clinical skills (1)
- Clinical variation (1)
- Cln3 (1)
- Clonidine (1)
- Clostridioides difficile (1)
- Clostridium (1)
- Closure (1)
- Cluster (1)
- Cluster randomization (1)
- Clustering (1)
- Co-culture (1)
- Co-morbidity (1)
- Coagulopathy management (1)
- Coexistence (1)
- Cofilin (1)
- Cognitive neurology (1)
- Cognitive psychology (1)
- Cohort Analysis (1)
- Cohort study (1)
- Colchicum (1)
- Cold pain (1)
- Colitis Ulcerosa (1)
- Collagen antibody-induced arthritis (1)
- Collagen hemostat (1)
- Collagen type I (1)
- Collagen type III (1)
- Collagens (1)
- Colloids (1)
- Colon cancer (1)
- Colon capsule endoscopy (1)
- Colonisation (1)
- Combined immune checkpoint blockade (1)
- Combo® DTS (1)
- Communicable diseases (1)
- Community health services (1)
- Comorbidities (1)
- Comorbidity (1)
- Comparative effectiveness research (1)
- Comparative study (1)
- Comparators (1)
- Compartmental modeling (1)
- Competencies (1)
- Complement Regulator (1)
- Complement cascade (1)
- Complement system (1)
- Complementary medicine (1)
- Complementation rate (1)
- Complete heart block (1)
- Complex II (1)
- Complex hernia (1)
- Complex networks (1)
- Complexin 1 (1)
- Complexin-1 (1)
- Complexome profiling (1)
- Complication (1)
- Comprehensive cancer centers (1)
- Computational biology and bioinformatics (1)
- Computational model (1)
- Computed axial tomography (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer hardware (1)
- Computer science (1)
- Computer simulation (1)
- Computer software (1)
- Computer-aided drug design (1)
- Computers (1)
- Concept paper (1)
- Conception (1)
- Concurrent chemoradiotherapy (1)
- Conditional gene trap (1)
- Conduct problems (1)
- Conduit function (1)
- Confocal endomicroscopy (1)
- Conformational change (1)
- Congenital CMVinfection (1)
- Congenital anomalies (1)
- Congenital duodenal obstruction (1)
- Congenital ocular motor apraxia (1)
- Coniosporium corticale (1)
- Consciousness (1)
- Consensus methods (1)
- Conservative (1)
- Consortia (1)
- Constrained posture (1)
- Contact precautions (1)
- Contractile function (1)
- Contrast-Enhancing Lesions (1)
- Contrast-enhanced (1)
- Conventional Chemotherapeutic (1)
- Conventional synthetic disease-modifying antirheumatic drug (1)
- Coping (1)
- Copy number variation (1)
- Cord blood transplantation (1)
- Core needle biopsy (1)
- Cornea (1)
- Coronary artery disease (1)
- Coronary artery disease (CAD) (1)
- Coronary intervention (1)
- Cost-effectiveness (1)
- Cost-effectiveness analysis (1)
- Couch tracking (1)
- Council for International Organizations of Medical Sciences (1)
- CoxVa (1)
- Coxibs (1)
- Craniomandibular disorders (1)
- Credentialing (1)
- Creeping Disease (1)
- Crispr/Cas (1)
- Critical Online Reasoning Assessment (1)
- Critical bleeding (1)
- Critical care (1)
- Critical care and emergency medicine (1)
- Critical haematocrit (1)
- Critical pathway (1)
- Cross-contamination (1)
- Cross-sectional (1)
- Cross-sectional study (1)
- Crosscorrelation (1)
- Crossmodal (1)
- Cryo-electron microscopy (1)
- Cryoablation (1)
- Cryoballoon (1)
- Cryptococcus (1)
- Cryptostroma corticale (1)
- CspA (1)
- Cumulative dose (1)
- Cure (1)
- Curriculum (1)
- Curvilinear dose response (1)
- CyberKnife (1)
- Cyp46a1 (1)
- CysLTR1 (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cystic fibrosis (1)
- Cytokine (1)
- Cytology (1)
- Cytomegalovirus (CMV) (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytotoxic CD8+ T cell (1)
- C‐reactive protein (1)
- D-dimer (1)
- D2-autoreceptor (1)
- DAMP (1)
- DAMPs (1)
- DBH genotype (1)
- DCM (1)
- DDA (1)
- DDIT4 (1)
- DEE (1)
- DFNB9 (1)
- DHA (1)
- DILI database case quality (1)
- DKK1 (1)
- DKTK-ROG (1)
- DLBCL (1)
- DMARDs (synthetic) (1)
- DME (1)
- DMXAA (1)
- DNA Damage (1)
- DNA double-strand break repair (1)
- DNA repair (1)
- DNA replication (1)
- DNA sequence analysis (1)
- DNA sequencing (1)
- DNA-binding proteins (1)
- DNA-protein crosslinks (1)
- DOK1 (1)
- DR5 (1)
- DSAEK (1)
- DSS /AOM (1)
- DTHR (1)
- DUBs (1)
- DYRK1A (1)
- DYT1 (1)
- Dabigatran (1)
- Dancer (1)
- Darmerkrankung (1)
- Darreichungsform (1)
- Darunavir (1)
- Data acquisition (1)
- Data mining (1)
- Data monitoring (1)
- Data protection (1)
- Data validation (1)
- Database (1)
- Database searching (1)
- Databases (1)
- Dataset bias (1)
- Datenqualität (1)
- Datenschutz (1)
- David technique (1)
- Decision impact (1)
- Decision-making (1)
- Decolonization (1)
- Deep brain stimulation (1)
- Deficient Inhibition (1)
- Deformation (1)
- Delayed Cerebral Ischemia (1)
- Delayed union (1)
- Deletion mutation (1)
- Delivery mode (1)
- Delivery quality assurance (1)
- Delphi Survey (1)
- Delphie-Befragung (1)
- Dementia (1)
- Dendritic cell (1)
- Dendritic cell population (1)
- Dendritic cells (1)
- Dendritic spines (1)
- Denervation (1)
- Dengue (1)
- Dengue fever (1)
- Dengue virus (1)
- Denguefieber (1)
- Density equalizing (1)
- Density-equalizing mapping (1)
- Dental implants (1)
- Dental phobia (1)
- Dental training (1)
- Dentition (1)
- Depolarization (1)
- Dermal fat (1)
- Dermatomyositis (1)
- Desinfektion von Flugzeugen (1)
- Desmin (1)
- Determination method (1)
- Developmental disorders (1)
- Devic disease (1)
- Devic syndrome (1)
- Diabetic nephropathy (1)
- Diagnostic differentiation (1)
- Diagnostic techniques and procedures (1)
- Diagnostic test (1)
- Diagnostik von MLL Translokationen (1)
- Diary Data (1)
- Dicer (1)
- Dichloromethane (1)
- Didaktik (1)
- Diesel (1)
- Dietary intake (1)
- Differential expression (1)
- Diffuse astrocytoma (1)
- Diffuse large B cell lymphoma (1)
- Diffusion of Innovations (1)
- Digenic model (1)
- Digestive system (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital ethics (1)
- Digital hybrid visualization (1)
- Digital mammography (1)
- Digital rectal examination (1)
- Digital transformation (1)
- Digitale Ethik (1)
- Digitale Transformation (1)
- Digitalisierung (1)
- Digitalization (1)
- Dilated cardiomyopathy (1)
- Dimer (1)
- Dimers (Chemical physics) (1)
- Dipeptide (1)
- Diphosphonates (1)
- Direct Acting Antivirals (DAA) (1)
- Direct acting antiviral therapies (1)
- Direct-acting antiviral agents (DAAs) (1)
- Disabilities (1)
- Disabling back pain (1)
- Disc herniation (1)
- Discs large (1)
- Disease burden (1)
- Disease management (1)
- Diseases (1)
- Disinfection of aircraft (1)
- Disintegration (1)
- Dissemination (1)
- Dissociative seizures (1)
- Distance to water (1)
- Distress (1)
- Distress screening (1)
- Distribution (1)
- Dog (1)
- Dogs (1)
- Domestic (1)
- Donor Selection (1)
- Dorsolateral prefrontal cortex (1)
- Dose optimization (1)
- Doubling time (1)
- Down's syndrome (1)
- Doxorubicin (1)
- Drug (1)
- Drug Discovery (1)
- Drug Therapy (1)
- Drug discovery (1)
- Drug hepatotoxicity (1)
- Drug induced liver injury (1)
- Drug interactions (1)
- Drug permeability (1)
- Drug resistance/synergy (1)
- Drug screens (1)
- Drug targeting (1)
- Dual energy CT (1)
- Dual therapy (1)
- Dual-Source CT (1)
- Duchenne’s muscular dystrophy (1)
- Dumon stents (1)
- Duodenal atresia (1)
- Duodenal stenosis (1)
- Dvc1 (1)
- E protein structure (1)
- E-cadherin (1)
- E-cadhérine (1)
- E-learning (1)
- E. coli (1)
- E/I-Balance (1)
- E3-Ligases (1)
- EBM (1)
- ECLS (1)
- ECM (1)
- EDB (1)
- EDTA-plasma (1)
- EEG reference choices (1)
- EFP1 (1)
- EGF (1)
- EGFL7 (1)
- EGFP (1)
- EGFR inhibitor (1)
- EGFR pathway (1)
- EGR1-dependent transcription (1)
- EIIIB (1)
- ELISA (1)
- ELSID-Diabetes (1)
- EMD 55900 (1)
- EMD 72000 (1)
- EMT (1)
- EPA (1)
- EQ (1)
- EQIP (1)
- ER stress (1)
- ERBB2 (1)
- ERBB2 (HER2/neu) (1)
- ERK3/MAPK6 (1)
- ERM (1)
- ERMS (1)
- ERP (1)
- ERSCongress (1)
- ES (1)
- ES cells (1)
- ESBL (1)
- ESMO-MCBS (1)
- ET (1)
- ETP-ALL (1)
- ETS (1)
- EWS/Fli1 (1)
- EZ-IO® needle driver (1)
- Early Rheumatoid Arthritis (1)
- Early diagnosis (1)
- Early goal-directed therapy (1)
- Early intervention (1)
- Early recurrence (1)
- Ebola virus (1)
- Echocardiography (1)
- Echovirus-30 (1)
- Eclampsia (1)
- Ecological momentary assessment (1)
- Economic analysis (1)
- Economic benchmarks (1)
- Economic evaluation (1)
- Economic impact (1)
- Economics (1)
- Ectopic bone formation (1)
- Edentulous jaw (1)
- Edoxaban (1)
- Educación médica (1)
- Efavirenz (1)
- Effective connectivity (1)
- Effectivity (1)
- Efficacy (1)
- Eicosanoids (1)
- Eignungsprüfung (1)
- Einfachauswahlverfahren (1)
- Eingangstest (1)
- Einreibetechnik (1)
- Elastogenesis (1)
- Elderly patients (1)
- Elective caesarean section (1)
- Electrical accident (1)
- Electrical instability (1)
- Electrical stimulation (1)
- Electroencephalography – EEG (1)
- Electrolytes (1)
- Electron transport chain (1)
- Electronic cigarettes (1)
- Electrophysiology (1)
- Electrotonic analysis (1)
- Elektroenzephalographie (1)
- Elektronenmikroskopie (1)
- Elevation (1)
- Elimination (1)
- Ellipsoids (1)
- Embolization (1)
- Embryos (1)
- Emergency (1)
- Emergency medicine (1)
- Emotion (1)
- Emotion processing (1)
- Emotional recognition (1)
- Empathy (1)
- Empfehlungen (1)
- Emphysema (1)
- Employment (1)
- Employment effect (1)
- End-of-life decisions (1)
- Endocrine cancer (1)
- Endometrial cancer (1)
- Endometriosis (1)
- Endoplasmic reticulum (1)
- Endoscopic coronary revascularisation (1)
- Endoscopic retrograde Cholangiopancreatography (ERCP) (1)
- Endoscopic ultrasound (1)
- Endoskopik koroner revaskülarizasyon (1)
- Endosomes (1)
- Endothelial cell (EC) (1)
- Endothelial nitric oxide synthase (1)
- Endothelium (1)
- Endotoxins (1)
- Endovascular repair (1)
- Endovaskuläre Behandlung (1)
- Endpoints (1)
- Enfermedades crónicas (1)
- England (1)
- Enteral nutrition (1)
- Enteric nervous system (1)
- Enterobacteriaceae (1)
- Enterostomy (1)
- Enterostomy closure (1)
- Enterostomy formation (1)
- Entfernung (1)
- Entorhinal cortex lesion (1)
- Entrenamiento práctico (1)
- Entzündung (1)
- EnvZ signalling (1)
- Envenomation (1)
- Environmental chemistry (1)
- Enzyme kinetics (1)
- Enzyme mechanisms (1)
- Enzyme regulation (1)
- Epidemiological data (1)
- Epidermolysis bullosa simplex with muscular dystrophy (1)
- Epidural block (1)
- Epilepsie (1)
- Epileptic seizures (1)
- Epileptische Anfälle (1)
- Epithelial cells (1)
- Epstein–Barr virus (1)
- Equipment (1)
- Equity (1)
- Eradication (1)
- Ergonomic analysis (1)
- Ergonomie am Arbeitsplatz (1)
- Ergonomische Analyse (1)
- Erythema migrans (1)
- Erythrocytes (1)
- Erythropoiesis (1)
- Esophageal adenocarcinoma (1)
- Esophageal adenocarcinoma (EAC) (1)
- Esophagectomy (1)
- Esophagogastric (1)
- Estradiol (1)
- Estrogen Receptor Modulators (1)
- Ethnicity (1)
- European Society for Immunodeficiencies (ESID) (1)
- European babesiosis (1)
- European registry for idiopathic pulmonary fibrosis (eurIPFreg) (1)
- Evaluation in microsurgery (1)
- Evaluationspraxis (1)
- Everolimus resistance (1)
- Evidence based medicine (1)
- Evidence-based dentistry (1)
- Evidence-based guidelines (1)
- Evidenzbasierte Medizin (1)
- Evolutionary biology (1)
- Exacerbations (1)
- Examination questions (1)
- Excitability (1)
- Exercise challenge at an ambient temperature (1)
- Exercise challenge in a cold chamber (1)
- Exercise testing (1)
- Exercise therapy (1)
- Exercise-induced bronchoconstriction (1)
- Exosomes (1)
- Experimental autoimmune encephalomyelitis (1)
- Experts (1)
- Expression (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extension study (1)
- External-/self-assessment (1)
- Extinction (1)
- Extracellular RNA (1)
- Extracellular RNA (eRNA) (1)
- Extracellular matrix proteins (1)
- Extracellular signal-regulated kinase 1/2 (1)
- Extracellular vesicles (1)
- Extracorporeal circulation (1)
- Extracorporeal life support (1)
- Extracorporeal purification (1)
- Extreme hypo-fractionation (1)
- F508del homozygous (1)
- FAAM (1)
- FAIR (1)
- FAK (1)
- FAM134B (1)
- FAV00A (1)
- FEV1 (1)
- FFLU (1)
- FFPE (1)
- FGFR (1)
- FIB-4 (1)
- FIV (1)
- FLT3 (1)
- FOLFIRI (1)
- FOXO3a (1)
- FREEDOM (1)
- FSS (1)
- FX06 (1)
- Facet joint osteoarthritis (1)
- Factor H (1)
- Factor analysis (1)
- Faculty Development (1)
- Falciparum (1)
- Fallbeispiele (1)
- Family Physician (1)
- Fascia (1)
- Fast-track (1)
- Fat layer (1)
- Fatty acids (1)
- Fbw7 (1)
- Fc receptor (1)
- Fear conditioning (1)
- Feasibility (1)
- Feature tracking (1)
- Feedback (1)
- Feedback loop (1)
- Feline bartonellosis (1)
- FemNAT-CD (1)
- Female (1)
- Female adolescents (1)
- Females (1)
- Feminismus (1)
- Femoral neck (1)
- Fertigkeiten (1)
- Fertilität (1)
- Fertilité (1)
- Fetal bovine serum (1)
- Fever (1)
- Fevers (1)
- Fibrinolytic (1)
- Fibroblast growth factor (1)
- Fibronectin (1)
- Fibrotest (1)
- Fibulin-4 (1)
- Fibulin-5 (1)
- Filovirus cell entry; attachment factors redundancy; SH-SY5Y cell line; host–pathogen interactions (1)
- Finanzierung (1)
- Finite Element Method (1)
- First experience with patients (1)
- First site of metastatic disease (1)
- First-line combination antiretroviral therapy (1)
- First-line regimen (1)
- Five-Konzept (1)
- Fleas (1)
- FlexTouch (1)
- Flexibility (1)
- Flexible Endoscopic Evaluation of Swallowing (1)
- Fluorescence imaging (1)
- Fluorescence-in-situ-hybridization (FISH) (1)
- Fluorescent Probes (1)
- Foam rolling (1)
- Folic acid (1)
- Follow-up (1)
- Food effects (1)
- Foramen ovale (1)
- Forensics (1)
- Forkhead box (1)
- Formation dance (1)
- Foxp1 (1)
- Fracture risk (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Frankfurt <Main> / Klinikum (1)
- Frankfurt microsurgery course (1)
- Fresh frozen plasma (1)
- Frontotemporal dementia (1)
- Frühgeborenes (1)
- Fuchs endothelial dystrophy (1)
- Fuctional connectivity (1)
- Functional ankle instability (1)
- Functional capacity (1)
- Functional characterization (1)
- Functional connectivity (1)
- Functional electrical stimulation (1)
- Functional mitral regurgitation (1)
- Functional outcome (1)
- Functionally-impaired elderly (1)
- FungiScope® registry (1)
- Fusarium (1)
- Fusion Proteins, BCR-ABL (1)
- G-protein (1)
- G-protein-coupled receptors (1)
- G/P (1)
- G2A (1)
- G3BP (1)
- G9a/EHMT2/KMT1C (1)
- GABA (1)
- GABAergic interneurons (1)
- GHQ-28 (1)
- GLI inhibitors (1)
- GLUT1 (1)
- GM-CSF (1)
- GPCR (1)
- GPVI (1)
- GRADE (1)
- GRK2 (1)
- GRX1-roGFP2 (1)
- GSK2334470 (1)
- GSK3α (1)
- GSK3β (1)
- GVHD (1)
- GVL (1)
- Gaba (1)
- Gadopentate dimeglumine (1)
- Gads (1)
- Gait analysis (1)
- Gallbladder percutaneous drainage (1)
- Galleria mellonella (1)
- Games (1)
- Gamma-Band Activity (1)
- Gamma-aminobutyric acid (1)
- Gap junctions (1)
- Gas gangrene (1)
- Gastritis (1)
- Gastroesophageal reflux disease (1)
- Gastroesophageal reflux disease symptoms (1)
- Gastrointestinal bleeding (1)
- Gastrointestinal cancer (1)
- Gastrointestinal neoplasm (1)
- Gastrointestinal tract (1)
- Gaucher disease type III (1)
- Gaucher’s disease (1)
- Gebärmutterhalskrebs (1)
- Gemcitabine (1)
- Gender analysis (1)
- Gender equality (1)
- Gender gap (1)
- Gender reassigning surgery (1)
- Gene Regulation (1)
- Gene engineering (1)
- Gene expression prediction (1)
- Gene fusion (1)
- Gene microarray analysis (1)
- Gene ontology (1)
- Gene polymorphism (1)
- Gene prediction (1)
- Gene set analysis (1)
- Gene-protein assay (1)
- GeneMANIA (1)
- General clinical cardiology (1)
- General dental practice (1)
- General practice/family medicine (1)
- General practitioner (1)
- Generation Y (1)
- Generation time (1)
- Generic drugs (1)
- Genetic causes of cancer (1)
- Genome annotation (1)
- Genomic instability (1)
- Geographically weighted regression (GWR) (1)
- German (1)
- German PID-NET registry (1)
- Gesprächsführung (1)
- Gestational age (1)
- Gestational diabetes (1)
- Gesundheitsamt (1)
- Gezielte Therapie (1)
- Giant lymph node hyperplasia (1)
- Gift (1)
- Gimbaled tracking (1)
- Glaucoma (1)
- Gleason Score (1)
- Gleason upgrading (1)
- Glioma (1)
- Glivec® (1)
- Global protein synthesis rates (1)
- Glomerular Filtration Rate (1)
- Glomerular diseases (1)
- Glomerulonephritis (1)
- Glucocorticoids (1)
- Glucose Transporter Type 1 (1)
- Glycogen synthase kinase 3 beta (1)
- Glycolysis (1)
- Glycosphingolipids (1)
- Glyoxalase I (1)
- Goal-oriented care (1)
- Gold (1)
- Goserelin (1)
- Grado en medicina (1)
- Graft function (1)
- Graft survival (1)
- Gram negative bacteria (1)
- Gram-positive infection (1)
- Granule cell (1)
- Grass pollen (1)
- Greater tuberosity fractures (1)
- Gross tumor volume optimization (1)
- Growth cone (1)
- Growth factor (1)
- Growth factor signalling (1)
- Guided surgery (1)
- Guided tissue regeneration (1)
- Guideline (1)
- Guideline adherence (1)
- Gut-liver-axis (1)
- GvHD (1)
- Gαq/11 (1)
- H-Index (1)
- H1N1 (1)
- H3 receptor (1)
- H5N1 (1)
- HACA (1)
- HAEGARDA (1)
- HAI‐1 (1)
- HBV filaments (1)
- HBV genotypes (1)
- HBV reactivation (1)
- HBV surface protein (1)
- HCC recurrence (1)
- HCMV (1)
- HCV treatment (1)
- HDAC-inhibition (1)
- HER2 c-erbB2 (1)
- HER2-positive (1)
- HER2/neu (ERBB2) (1)
- HEV (1)
- HFrEF (1)
- HGF (1)
- HH (1)
- HIBCPP cells (1)
- HIF (1)
- HIF1α (1)
- HIFU (1)
- HILI (1)
- HIV protease inhibitors (1)
- HIV serodiagnosis (1)
- HIV therapy (1)
- HIV-1 escape restriction (1)
- HIV-RNA (1)
- HLA DQ haplotypes (1)
- HLA class I loss (1)
- HLA class II (1)
- HLA peptidome (1)
- HMA (1)
- HMGB1 (1)
- HODE (1)
- HRM (1)
- HRas (1)
- HSPC (1)
- HSV-1 (1)
- HSV-2 (1)
- HUVEC (1)
- Haematoma expansion (1)
- Haematopoietic stem cells (1)
- Haemodynamic monitoring (1)
- Haemostatics (1)
- Hand-foot syndrome (1)
- Haploidentical stem cell transplantation (1)
- Haplotypes (1)
- Hard-to-reach population (1)
- Hashimoto’s thyroiditis (1)
- Hausarztmangel (1)
- HbA1c (1)
- Head and neck Cancer (1)
- Head injury (1)
- Health Policy (1)
- Health Systems (1)
- Health care (1)
- Health care access (1)
- Health care resource utilization (1)
- Health care sector (1)
- Health care workers (1)
- Health education and awareness (1)
- Health information (1)
- Health literacy (1)
- Health policy (1)
- Health risk analysis (1)
- Health services (1)
- Health services research [MeSH] (1)
- Health-related quality of life (1)
- Health-seeking behaviour (1)
- Health‐related quality of life (1)
- Heart regeneration (1)
- Heat dissipation (1)
- Heat pain (1)
- Hebbian plasticity (1)
- Hedgehog (1)
- Hedgehog pathway (1)
- Helpline (1)
- Hemagglutination inhibition assay (1)
- Hematocrit value (1)
- Hematopoietic stem and progenitor cells (HSPCs) (1)
- Hematopoietic stem cell transplantation (1)
- Hematopoietic stem cells (1)
- Hematoxylin staining (1)
- Hemodilution (1)
- Hemodynamic management (1)
- Hemodynamics (1)
- Hemoglobin (1)
- Hemophilia A (1)
- Hemorrhagic shock (1)
- Hemostasis (1)
- Hemostatics (1)
- HepaRG cells (1)
- Hepatic encephalopathy (1)
- Hepatitis (1)
- Hepatitis B (1)
- Hepatitis B infection (1)
- Hepatitis B vaccination (1)
- Hepatitis B virus (1)
- Hepatitis C (1)
- Hepatitis C, Chronic (1)
- Hepatitis c (1)
- Hepatotoxicity (1)
- Herbal hepatotoxicity (1)
- Herbalife (1)
- Herbs (1)
- Herd immunity (1)
- Hereditary breast and ovarian cancer (1)
- Hereditary breast cancer (1)
- Hereditary ovarian cancer (1)
- Heregulin (1)
- Hernia recurrence (1)
- Hernia surgery (1)
- Heterogeneity (1)
- Hexavalent vaccine (1)
- HhAntag (1)
- HiC (1)
- HiChIP (1)
- Hif-1 alpha (1)
- Hif1α (1)
- High-dose chemotherapy (1)
- High-income countries (1)
- High-intensity interval endurance training (1)
- High-risk cardiac surgery (1)
- High-risk patient (1)
- High-throughput screening (1)
- Highly infectious diseases (1)
- Hindu Kush Himalayas (1)
- Hip (1)
- Hippo signaling (1)
- Hippocampal volume (1)
- Hirnverletzung (1)
- Hispanic people (1)
- Histone post-translational modifications (1)
- Histoplasma qPCR (1)
- Hmox1 (1)
- Hochansteckende Krankheiten (1)
- Hochschuldidaktik (1)
- Hodgkin’s lymphoma (1)
- Homeostatic plasticity (1)
- Homicide (1)
- Homocysteine (1)
- Hormone de régression müllérienne (1)
- Horner's syndrome (1)
- Horses (1)
- Hospital (1)
- Hospitalization (1)
- Hospitalizations (1)
- Host-directed therapies (1)
- Host-targeting agents (HTAs) (1)
- House dust mite allergy (1)
- Household contacts (1)
- Hrvaška (1)
- Hsp70 (1)
- Hsp90 inhibitor (1)
- HuR (1)
- Huh7 (1)
- Human (1)
- Human experimental pain models (1)
- Human immunodeficiency virus (HIV) (1)
- Human olfaction (1)
- Human physiology (1)
- Human prostate (1)
- Humangenetik (1)
- Humans (1)
- Humeral fractures (1)
- Humerus (1)
- Hungary (1)
- Hydrocephalus (1)
- Hydroxyapatite (1)
- Hydroxychloroquine (1)
- Hydroxycut (1)
- Hydroxyurea (1)
- Hymenoptera venom immunotherapy (1)
- Hyperammonemic encephalopathy (1)
- Hypofractionated radiotherapy (1)
- Hyponatremia (1)
- Hypoxia inducible factor (1)
- Hypoxic responses (1)
- Hysterektomie-Prävalenz (1)
- I-FABP (1)
- I-PRF (1)
- ICSI (1)
- IDH mutation (1)
- IDH1 inhibitor (1)
- IDO1 (1)
- IFA (1)
- IFN (1)
- IFN-γ expression (1)
- IGF (1)
- IGRA (1)
- IKKε (1)
- IKZF1 (1)
- IL -17 (1)
- IL -23 (1)
- IL 23p19 knockout mouse (1)
- IL-11 (1)
- IL-12 (1)
- IL-13 (1)
- IL-15 (1)
- IL-18 binding protein (1)
- IL-18BP (1)
- IL-21 (1)
- IL-22 (1)
- IL-27 cytokine (1)
- IL-33 (1)
- IL10R (1)
- ILUVIEN (1)
- IMiD® (1)
- IPEX (1)
- IPS e.max system (1)
- IRES translation (1)
- ISS (1)
- ITGA7 (1)
- IUIS classification 2017 (1)
- IV iron (1)
- IVA interference tandem mass spectrometry (1)
- IVD degeneration (IVDD) (1)
- IVDU (1)
- IVF (1)
- Iceland (1)
- Idarucizumab (1)
- Identity (1)
- Idiopathic pulmonary fibrosis (IPF) (1)
- IgE (1)
- IgG (1)
- IgG substitution therapy (1)
- IgG4-related disease (1)
- IgGAM (1)
- Illumina (1)
- Image processing (1)
- Image processing (computer-assisted) (1)
- Imaging (1)
- Imaging genetics (1)
- Imaging in LGG (1)
- Imaging, three-dimensional (1)
- Immediate loading (1)
- Immediate placement (1)
- Immobilization (1)
- Immune Response (1)
- Immune cells (1)
- Immune receptor signaling (1)
- Immune response (1)
- Immune system (1)
- Immunity (1)
- Immunmodulation (1)
- Immunoassays (1)
- Immunocompromised (1)
- Immunoglobulin Therapy (1)
- Immunohistochemistry techniques (1)
- Immunological techniques (1)
- Immunologie (1)
- Immunology and Microbiology Section (1)
- Immunomodulation (1)
- Immunomonitoring (1)
- Immunosenescence (1)
- Immunostaining (1)
- Immunosuppression (1)
- Immunosuppressive Agents (1)
- Immunosuppressive agents (1)
- Immunosuppressive therapy (1)
- Impfung (1)
- Implant-supported bars (1)
- Implementación (1)
- Impulse control (1)
- In vivo (1)
- In-hospital cardiac arrest (1)
- In-line filtration (1)
- In-vivo (1)
- IncL (1)
- Incidence rate (1)
- Incomplete colonoscopy (1)
- Independent component analysis (1)
- Independent laboratories (1)
- Indeterminate biliary stricture (1)
- Index (1)
- Indication (1)
- Individualisierung des Studiums (1)
- Individualized intervention (1)
- Individuelle Studienbegleitung (1)
- Indonesia (1)
- Indoor air pollution (1)
- Induced membrane technique (1)
- Induced pluripotent stem cells (1)
- Induced sputum (1)
- Inertial motion capture (1)
- Infant (1)
- Infant leukemia (1)
- Infants (1)
- Infarction (1)
- Infections (1)
- Infectious disease (1)
- Infectious disease epidemiology (1)
- Infektionsabwehr (1)
- Infektionsprophylaxe (1)
- Infliximab (1)
- Inflow obstruction (1)
- Influenza (1)
- Information theory (1)
- Information transfer (1)
- Infusion management (1)
- Injuries (1)
- Injury (1)
- Inner ear therapy (1)
- Inpatients (1)
- Inside-out Signaling (1)
- Insula (1)
- Insulin (1)
- Insulin secretion (1)
- Insulin therapy (1)
- Integrated multimodal training (1)
- Integration (1)
- Integrin (1)
- Integrins (1)
- Intelligence (1)
- Intelligence tests (1)
- Intensive care outcome (1)
- Intensive care unit (1)
- Inter-study reproducibility (1)
- Interdisziplinarität (1)
- Interferon-free HCV treatment (1)
- Interferons (1)
- Interleukin-17A (1)
- Interleukin-18 (1)
- Interleukin-18 binding protein (1)
- Interleukin-22 binding protein (1)
- Intermediate filaments (1)
- International body passport (1)
- Internet citation (1)
- Interspecific competition (1)
- Interstitial lung diseases (ILD) (1)
- Interventional Trials (1)
- Interventional cardiology (1)
- Intervertebral disc degeneration (1)
- Intestinal failure-associated liver disease (1)
- Intestinal neoplasms (1)
- Intolerance (1)
- Intra-abdominal infection (1)
- Intracellular pathogens (1)
- Intracerebral haemorrhage (1)
- Intracranial embolism (1)
- Intracranial haemorrhage (1)
- Intracranial hemorrhage (1)
- Intragastric balloon (1)
- Intraoral scanners (1)
- Intraosseous access (1)
- Intratumoral (1)
- Intratympanic drug delivery (1)
- Intravenous Drug User (1)
- Intravenous injections (1)
- Invasive candidiasis (1)
- Invasive fungal infection (1)
- Invasive fungal infections (1)
- Inzidenzkorrektur (1)
- Ionenkanal (1)
- Ipilimumab (1)
- Ireb2 (1)
- Ireland (1)
- Iron Overload (1)
- Iron chelation (1)
- Iron deficiency (1)
- Irregular vaccination (1)
- Ischemia-reperfusion injury (1)
- Ischemia–reperfusion injury (1)
- Isolierung <Medizin> (1)
- Isoproterenol (1)
- Issue 96 (1)
- Italy (1)
- Itpr1 (1)
- Ivor Lewis esophagectomy (1)
- Ixodes ricinus (1)
- JAK inhibition (1)
- JNK3 (1)
- Jak2(V617F) (1)
- Joint destruction (1)
- Joint loading (1)
- Joubert syndrome (1)
- Jumping (1)
- Juvenile myoclonic epilepsy (1)
- KAP (1)
- KCGS (1)
- KCNJ2 mutation (1)
- KCNQ4 (1)
- KDIGO (1)
- KIF (1)
- KIF11 (1)
- KIR (1)
- KLK5 (1)
- KOOS IV (1)
- KRAS (1)
- Kaisidis plate (1)
- Karyotypes (1)
- Kegelschnecke (1)
- Keratinocytes (1)
- Ketogenic Diet (1)
- Ki-67 (1)
- Ki-67/MIB1 (1)
- Ki67 transgenic c‐myc/TGFα mice (1)
- Kidney Transplantation (1)
- Kidney disease (1)
- Kidney neoplasm (1)
- Kidney transplant recipients (1)
- Kiefer (1)
- Kim-1 (1)
- Kinases (1)
- Kinder (1)
- Kindheit (1)
- Kinematic posture analysis (1)
- Kinematics (1)
- Kinetochore (1)
- Klinische Ergebnisse (1)
- Klinische Fertigkeiten (1)
- Knee joint (1)
- Knockout (1)
- Kongress (1)
- Konsensus Methode (1)
- Konzeption (1)
- Konzeptpapier (1)
- Krait (1)
- Kraniomandibuläre Dysfunktion (1)
- Krebs (1)
- Krebsforschung (1)
- Kupffer cells (1)
- Kynurenine (1)
- Körperbild (1)
- Körpermodifikation (1)
- L1 cell-adhesion molecule (L1-CAM) (1)
- LABAs (1)
- LAMP3 (1)
- LAMTOR2 (1)
- LAT (1)
- LC-NE system (1)
- LC3 I/II (1)
- LC3B (1)
- LCH (1)
- LC–MS/MS (1)
- LDL (1)
- LDL-cholesterol (1)
- LFA-1 (1)
- LFP (1)
- LHRH receptor (1)
- LIR interaction, (1)
- LIVIN (1)
- LM11A 31 (1)
- LN229 (1)
- LNS (1)
- LOS (1)
- LPP (1)
- LRBA (1)
- LSCC (1)
- LTB4 (1)
- LTBI (1)
- LUBAC (1)
- LUT (1)
- Laboratory techniques and procedures (1)
- Lack of immunity (1)
- Lactation (1)
- Lactic acidosis (1)
- Lactobacillus (1)
- Lafora disease (1)
- Lamivudine (1)
- Landarztprogramm (1)
- Langzeitpflege (1)
- Laparoscopic fundoplication (1)
- Laparostomy (1)
- Laparotomy. Joel-Cohen (1)
- Laser navigation system (1)
- Late Gadolinium Enhancement (LGE) (1)
- Late gadolinium enhancement (1)
- Late presentation (1)
- Latent transforming growth factor β-binding protein 4 (1)
- Lateral recess stenosis (1)
- Laterality (1)
- Le carcinome épidermoïde oral (1)
- Leadership (1)
- Learning algorithms (1)
- Learning and memory (1)
- Learning outcomes (1)
- Leber congenital amaurosis (1)
- Lectin affinity plasmapheresis (1)
- Lecture (1)
- Leflunomide (1)
- Left Ventricular Mass (1)
- Left ventricular assist device (1)
- Left ventricular function (1)
- Left ventricular mass (1)
- Left ventricular non-compaction, (1)
- Leg alignment (1)
- Lehre (1)
- Lehrerausbildung (1)
- Leistungsorientierte Mittelvergabe (1)
- Leitlinie (1)
- Lenalidomide (1)
- Length of stay (1)
- Lentiviral vectors (1)
- Lernerfolgsmessung (1)
- Lernziele (1)
- Les macrophages associés aux tumeurs (1)
- Lesion (1)
- Leukemia (1)
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1)
- Leukocyte elastase (1)
- Leukocytes (1)
- Leukodystrophy (1)
- Leukotriene (1)
- Lice (1)
- Light sheet fluorescence microscopy (1)
- Lineage (1)
- Lineage tracing (1)
- Linkage (1)
- Lipid metabolism (1)
- Lipid signaling (1)
- Lipid trafficking (1)
- Lipidol (1)
- Lipiodol (1)
- Lipodystrophy (1)
- Lipopolysaccharide-binding protein (1)
- Liquid filled MicroLion ion chamber array (1)
- Lithium (1)
- Liver (1)
- Liver cancer (1)
- Liver enzymes (1)
- Liver injury (1)
- Liver metastases (1)
- Liver resection (1)
- Liver transplant (1)
- Liver-Related Complications (1)
- Liver-related complications (1)
- LiverTox (1)
- Livestock (1)
- LncRNA (1)
- LncRNA - long noncoding RNA (1)
- Local IgE (1)
- Local allergic rhinitis (1)
- Local climate (1)
- Local control (1)
- Localized prostate cancer (1)
- Locally advanced (1)
- Loco-regional control (1)
- Locomotor circuit (1)
- Lomentospora prolificans (1)
- Long term output (1)
- Long term result (1)
- Long-term (1)
- Long-term follow up (1)
- Longitudinal analysis (1)
- Low birth weight infant (1)
- Low volume prep (1)
- Low-dose X-irradiation (1)
- Low-dose ionizing radiation (1)
- Low-grade glioma (1)
- Low-virulent infection (1)
- Lower back pain (1)
- Lpar2 (1)
- Ltbp-4 (1)
- Ltbp-4L (1)
- Ltbp-4S (1)
- Ltbp4 (1)
- Lucigenin (1)
- Luftverkehr (1)
- Lumbar spinal canal stenosis (1)
- Lumbar stenosis (1)
- Lumican (1)
- Lung (1)
- Lung Cancer (1)
- Lung adenocarcinoma (1)
- Lung cancer (1)
- Lung failure (1)
- Lungenerkrankungen (1)
- Lyme Borreliosis (1)
- Lyme borreliosis (1)
- Lyme disease - Borreliosis (1)
- Lymph node (1)
- Lymphadenopathy (1)
- Lymphangiogenesis (1)
- Lymphangioleiomyomatosis (1)
- Lymphedema (1)
- Lymphocyte (1)
- Lymphoepithelioma (1)
- Lymphoid Neoplasia (1)
- Lymphoid tissues (1)
- Lymphoma (1)
- Lymphomas (1)
- Lysophosphatidic acids (1)
- Lysosomal storage disease (1)
- MACE (1)
- MAGGIC score (1)
- MAIT cell (1)
- MC-Fragen (1)
- MCP (1)
- MCP-1 (1)
- MDM2 (1)
- MDR1 (1)
- MEDIC (1)
- MEIS2 (1)
- MELD (1)
- MET (1)
- MK-0457 (1)
- MKP1 (1)
- MLC tracking (1)
- MLH1 (1)
- MLKL (1)
- MLL-rearranged leukemia (1)
- MLN8237 (1)
- MLV (1)
- MM-121 (1)
- MMF (1)
- MMP14 (1)
- MMP2 (1)
- MOLLI (1)
- MPA (1)
- MPM (1)
- MPN (1)
- MPN-U (1)
- MR spectroscopy (1)
- MR-based histology (1)
- MR-proADM (1)
- MR-spectroscopy (1)
- MRI patterns of gliomas (1)
- MRP4 (1)
- MSC-subsets (1)
- MSM (1)
- MTCL (1)
- MTRNR1 (1)
- MTT (1)
- MTT assay (1)
- Machine learning algorithms (1)
- Machine teaching (1)
- Macrophage Transdifferentiation (1)
- Macrophage polarization (1)
- Macular neovascularization (1)
- Magnetic resonance (1)
- Magnetic resonance imaging (MRI) (1)
- Magnetoencephalography (1)
- Magnetresonanztomografie (1)
- Maintenance treatment (1)
- Major bleeding (1)
- Major infection after cardiac surgery (1)
- Malaria prevalence (1)
- Malariae (1)
- Male (1)
- Male Population (1)
- MammaPrint (1)
- Mammalian target of rapamycin (1)
- Mammaplasty (1)
- Mammary gland (1)
- Manatee invariant (1)
- Mandible (1)
- Mania (1)
- Manner of death (1)
- Manufacturing (1)
- Maple bark disease (1)
- Maple bark strippers’ lung (1)
- Mapping (1)
- Marburg virus (1)
- Marginal grafts (1)
- Marker genes (1)
- Markov model (1)
- Massive Online Open Course (1)
- Mastectomy (1)
- Maternal morbidity (1)
- Mathematical methods (1)
- Mathematical model (1)
- Mathematical models (1)
- Mathematische Biologie (1)
- Mcl-1 (1)
- MdM2 (1)
- Measles (1)
- Measurement equipment (1)
- Mechanical ankle instability (1)
- Meckel’s diverticulum (1)
- Medical (1)
- Medical Education (1)
- Medical communication (1)
- Medical ethics (1)
- Medical hypoxia (1)
- Medical imaging (1)
- Medical implants (1)
- Medical management (1)
- Medical research (1)
- Medical school (1)
- Medical staff (1)
- Medical student (1)
- Medical traineeship (1)
- Medication changes (1)
- Medicine and health sciences (1)
- Medizin (1)
- Medizinische Abbildung (1)
- Medizinische Ausbildung (1)
- Medizinische Ethik (1)
- Medizinische Lehre (1)
- Medizinische Psychologie (1)
- Medizinstudierende (1)
- Melanoma (1)
- Membrane Attack Complex (1)
- Membrane Trafficking (1)
- Membrane assays (1)
- Membrane proteins (1)
- Membrane staining (1)
- Memory (1)
- Mena/VASP (1)
- Mental health (1)
- Mental health disorders (1)
- Mental health problems (1)
- Menthol (1)
- Mentor (1)
- Mesangial cells (1)
- Mesenchymal stem cell (1)
- Mesenchymal stem/stromal cells (1)
- Mesenchymal stromal cells (1)
- Mesenchymal stromal cells (MSC) (1)
- Mesh repair (1)
- Meta-analysis (1)
- Metaanalysis (1)
- Metabolic diseases (1)
- Metabolic syndrome (1)
- Metabolism (1)
- Metabolism, Inborn Errors (1)
- Metalloproteases (1)
- Metastasis (1)
- Metastatic (1)
- Metastatic castration-resistant prostate cancer (1)
- Metastatic tumors (1)
- Methacholine challenge test (1)
- Methicillin resistance (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methionine (1)
- Methoden (1)
- Methotrexate (1)
- Mgm1p (1)
- MiSpEx Network (1)
- Mice (1)
- Micro RNAs (1)
- Micro-CT (1)
- MicroRNA-181a (1)
- MicroRNAs (miRNAs) (1)
- Microalgae (1)
- Microarray (1)
- Microbial mutation (1)
- Microfluidics (1)
- Microglia (1)
- Microglial cells (1)
- Micrognathia (1)
- Microphones (1)
- Microphysiological models (1)
- Microsatellite instability (1)
- Microstates (1)
- Microtubule (1)
- Midbrain/brainstem expression changes (1)
- Middle East respiratory syndrome coronavirus (1)
- Midkine (1)
- Midline laparotomy (1)
- Midwifery (1)
- Migration (1)
- Mild cognitive impairment (1)
- Minimal Residual Disease (MRD) (1)
- Minimal core of imaging (1)
- Minimal invasive (1)
- Minimally invasive surgical procedures (1)
- Minimally invasive transforaminal interbody fusion (1)
- Mislocalised proteins (1)
- Mitochondrial ROS (1)
- Mitochondrial amino acid tRNA synthetases (1)
- Mitochondrial complex I (1)
- Mitochondrial disease (1)
- Mitochondrial disorder (1)
- Mitochondrial dysfunction (1)
- Mitochondrial function (1)
- Mitochondrial proteins (1)
- Mitochondrial respiration (1)
- Mitochondrial shuttles (1)
- Mitochondrien (1)
- Mitomycin C (1)
- Mitoxantrone (1)
- Mobilization (1)
- Model Organism (1)
- Modell-Curriculum (1)
- Modellprojekt, (1)
- Moderating factors (1)
- Modified FDI criteria (1)
- Molar tooth sign (1)
- Mole-rat (1)
- Molecular diagnostic testing (1)
- Molecular genetics (1)
- Molecular imaging (1)
- Molecular marker (1)
- Molecular matched therapy (1)
- Molecular signatures (1)
- Molecular subtype (1)
- Molecular subtypes (1)
- Molecular therapy (1)
- Molecularly targeted therapy (1)
- Molekulare Therapie (1)
- Monacolin K (1)
- Monitoring (1)
- Monoclonal antibodies (1)
- Monocytes and macrophages (1)
- Monolithic crown (1)
- Monosaccharide Transport Proteins (1)
- Monte Carlo method (1)
- Monte Carlo simulation (1)
- Morbus Crohn (1)
- Morphological modeling (1)
- Mortalitätskorrektur (1)
- Motility disorder (1)
- Motivating factor (1)
- Motor neuron disease (1)
- Motor skills (1)
- Mountain (1)
- Mouse model (1)
- Moviprep (1)
- Mucomaix® matrix (1)
- Mucopolysaccharidoses (1)
- Multi-center (1)
- Multi-modal feedback (1)
- Multi-nucleated cardiomyocytes (1)
- Multi-resistant pathogens (1)
- Multidetector Computed Tomography (1)
- Multidetector computed tomography (1)
- Multidisciplinary management (1)
- Multidrug-resistant bacteria (1)
- Multidrug-resistant tuberculosis (1)
- Multilevel two-part modelling (1)
- Multimedia (1)
- Multimodal imaging (1)
- Multimorbid patients (1)
- Multimorbilidad (1)
- Multinomial logistic regression (1)
- Multinucleated giant cells (1)
- Multiomics (1)
- Multiple Sclerosis (1)
- Multiple choice Fragen (1)
- Multiple myeloma (1)
- Multiple trauma (1)
- Multisensory (1)
- Multivariable analysis (1)
- Muscarinic acetylcholine receptor (1)
- Muscle atrophy (1)
- Muscle tissue (1)
- Muscular diseases (1)
- Musculoskeletal (1)
- Musculoskeletal ultrasound (1)
- Music chair concepts (1)
- Musical rhythm (1)
- Musician (1)
- Musician-specific seating position (1)
- Muskuloskeletales System (1)
- Muskuloskelettale Erkrankungen (1)
- Mutation databases (1)
- Mutations (1)
- Myalgia (1)
- Mycoses (1)
- Myelin or myeloarchitecture (1)
- Myelodysplastic syndrome (1)
- Myelofibrosis (1)
- Myeloperoxidase (1)
- Myeloproliferative disease (1)
- Myocardial perfusion (1)
- Myocardial revascularization (1)
- Myocardial segmentation (1)
- Myonecrosis (1)
- Myotonic dystrophy (1)
- Mφs (1)
- N-Acetylaspartate (1)
- N-acetyl-L-cysteine (1)
- N-acetylcysteine (1)
- N-cadherin (1)
- N-cadhérine (1)
- N-hydroxysuccinimide (1)
- N-methyl-D-aspartate receptor (1)
- N-myc (1)
- N2 (1)
- NADH dehydrogenase (1)
- NADPH oxidase 4 (1)
- NAFL (1)
- NCAM (1)
- NCH93 (1)
- NDBI (1)
- NDNF interneurons (1)
- NDR1 (1)
- NDUFA6 (1)
- NDUFAF8 (1)
- NEAT1 (1)
- NEAT2 (1)
- NETs (1)
- NF-ĸB (1)
- NF-κB pathway (1)
- NF-кB (1)
- NFAT (1)
- NFκB (1)
- NGS (1)
- NHE (1)
- NHEJ (1)
- NIRS (1)
- NK cell subset (1)
- NK receptors (1)
- NKG2A blocking (1)
- NKT cell (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMDAR subunit GluN2B (1)
- NMO-IgG (1)
- NO (1)
- NOD2 (1)
- NOXA (1)
- NPC disease (1)
- NPH insulin (1)
- NPSR1 (1)
- NRAS (1)
- NS1608 (1)
- NS3 protease inhibitor (1)
- NS3-4A protease inhibitor (1)
- NS3/4A protease inhibitors (PI) (1)
- NS5A inhibitors (1)
- NS5B polymerase inhibitor (1)
- NSAIDs (1)
- NSC350625 (1)
- NSE (1)
- NSF (1)
- NSG mice (1)
- NSTEMI (1)
- NXF1 (1)
- Nackenmuskulatur (1)
- NanoBone (1)
- Nanocrystalline (1)
- Nanoparticles (1)
- Nanopore (1)
- National catalogue of competence-based learning objectives in dentistry (1)
- Native T1 (1)
- Native T1 mapping (1)
- Natriuretic peptide (1)
- Naturwissenschaften (1)
- Nav channel activity (1)
- Nav1.7 (1)
- Neck muscles (1)
- Necrosis (1)
- Necrotic area (1)
- Necrotizing enterocolitis (1)
- Necrotizing fasciitis (1)
- Needs assessment [MeSH] (1)
- Negative staining (1)
- Negative-pressure wound therapy (1)
- Neoadjuvant radiochemotherapy (1)
- Neoadjuvant therapy (1)
- Neonatal (1)
- Neonatal brain damage (1)
- Neonatal intensive care unit (1)
- Neonatal morbidity (1)
- Neonatal outcome (1)
- Neonatal urea cycle disorders (1)
- Neosexualitäten (1)
- Nephrectomy (1)
- Nephrons (1)
- Nerves (1)
- Nervous system diseases (1)
- Nesplora Aquarium (1)
- Network analysis (1)
- Network model (1)
- Neugeborenes (1)
- Neural function (1)
- Neural networks (1)
- Neural stem cells (1)
- Neuro-ophthalmology (1)
- Neurobiology of disease and regeneration (1)
- Neuroblastoma (1)
- Neurochemistry (1)
- Neurodegeneration (1)
- Neurodegenerative diseases (1)
- Neurodevelopment (1)
- Neurodevelopmental disorders (1)
- Neuroendocrine cancer (1)
- Neurogenese (1)
- Neurogenesis (1)
- Neuromyelitis optica (1)
- Neuronal dendrites (1)
- Neuronal homeostasis (1)
- Neuronal networks (1)
- Neuronal nitric oxide synthase (1)
- Neuronal plasticity (1)
- Neuropathic pain (1)
- Neurophysiology (1)
- Neuropsychological testing (1)
- Neuropsychology (1)
- Neurotoxicity (1)
- Neurotransmitter (1)
- Neurowissenschaften (1)
- Neutrophils (1)
- New Developments (1)
- Next generation sequencing (1)
- Nfe2l2 (1)
- Niche differentiation (1)
- Nicolaides-Baraitser syndrome (1)
- Nicotine (1)
- Nimotuzumab (1)
- Nociception (1)
- Nodular lymphocyte predominant Hodgkin lymphoma (1)
- Non-RCT (1)
- Non-alcoholic fatty liver disease (1)
- Non-allergic-rhinitis (1)
- Non-aneurysmal (1)
- Non-clear cell renal cell cancer (1)
- Non-coding RNAs (1)
- Non-falciparum (1)
- Non-invasive brain stimulation (1)
- Non-neuronal cholinergic system (1)
- Non-nucleoside polymerase inhibitors (NNI) (1)
- Non-operative (1)
- Non-perimesencephalic (1)
- Non-responder (1)
- Non-small-cell lung cancer (1)
- Non-steroidal anti-inflammatory drugs (1)
- Non-trauma (1)
- Non-urothelial (1)
- Noncoding RNA (1)
- Noninferiority (1)
- Nonsteroidal anti-inflammatory drugs (1)
- Nonunion (1)
- Non–small-cell lung cancer (1)
- Nordic questionnaire (1)
- Notch (1)
- Novel treatment target (1)
- NoxA1 (1)
- Nucleolus (1)
- Nucleophosmin-1 (1)
- Nucleus pulposus cells (1)
- Numerical simulation (1)
- Nurses (1)
- Nursing (1)
- Nutrition (1)
- Nutrition risk stratification (1)
- Nymphs (1)
- O-GlcNAcylation (1)
- OCT (1)
- OECD performance standards (1)
- OGTT (1)
- ONC201 (1)
- OPRM1 methylation (1)
- OPS (1)
- OR time (1)
- OXA-48 (1)
- Object perception (1)
- Object vision (1)
- Objectives (1)
- Objektivität (1)
- Observational (1)
- Observational studies (1)
- Obstetric care (1)
- Obstetrics (1)
- Obstetrics and gynecology (1)
- Occupational Accidents (1)
- Occupational disease (1)
- Occupational exposure (1)
- Occupational health (1)
- Occupational medicine (1)
- Ocular findings (1)
- Oesophageal cancer (1)
- Oesophagogastric cancer oxaliplatin (1)
- Off-pump surgery (1)
- Offene Versorgung (1)
- Okinawa (1)
- Okinawa diet (1)
- Older adults (1)
- Oldest-old (1)
- Olfactory diagnostics (1)
- Olfactory system (1)
- Omics (1)
- Oncologic surgery (1)
- Oncolytic adenovirus (1)
- Oncolytic virus (1)
- Oncotargets (1)
- One health (1)
- Online-Lehre (1)
- Online-Lernen (1)
- Online-Magazine (1)
- Opacity (1)
- Open abdomen (1)
- Open repair (1)
- Open source concept (1)
- Opioids (1)
- Oposterior urethral valve (1)
- Opportunistic infections (1)
- Oppositional defant disorder (1)
- Oppositional defiant disorder (1)
- Optic nerve atrophy (1)
- Optical coherence tomography angiography (1)
- Optical lenses (1)
- Oral Health Impact Profile (OHIP) (1)
- Oral and maxillofacial trauma (1)
- Oral implantology (1)
- Ordinary least squares (OLS) (1)
- Organ allocation (1)
- Organ motion (1)
- Organ preservation (1)
- Organ rinse (1)
- Organ shortage (1)
- Organ support (1)
- Organoids (1)
- Organs at Risk (1)
- Oroantral communication (1)
- Orphan disease (1)
- Orthodontist (1)
- Oryctolagus cuniculus (1)
- Osimertinib (1)
- Osmosensing (1)
- OspE (1)
- Osteoinduction (1)
- Osteonecrosis (1)
- Osteoporosis diagnosis (1)
- Oswestry Disability Score (1)
- Outcome assessment [MeSH] (1)
- Outcomes research (1)
- Outpatients (1)
- Ovale (1)
- Ovarian carcinoma (1)
- Overall survival (1)
- Oxaliplatin (1)
- Oxidativer Stress (1)
- OxyELITE Pro (1)
- Oxygen (1)
- Oxygen consumption (1)
- Oxygen uptake (1)
- Oxygen-derived free radicals (1)
- P-gp (1)
- P1NP (1)
- P2X7 receptor (1)
- PAH (1)
- PAI-1 (1)
- PAR (1)
- PARK4 (1)
- PARK6 (1)
- PARK7 (1)
- PAX3/FOXO1 (1)
- PBMC (peripheral blood mononuclear cells) (1)
- PBPK simulation (1)
- PBX1 (1)
- PC12 cells (1)
- PC12 neuronal differentiation (1)
- PCP (1)
- PCSK9 protein (1)
- PCV (1)
- PD-1 (1)
- PD-1 inhibitor (1)
- PDCD4 (1)
- PDD - Assessment - Screening (1)
- PDE inhibition (1)
- PDE‐5‐inhibitor (1)
- PDI (1)
- PDK1 (1)
- PEA-15 (1)
- PEGylated PLGA (PLGA-PEG) (1)
- PEI (1)
- PELICAN (1)
- PEM-technology (1)
- PF-06273340 (1)
- PFL (1)
- PGE2 (1)
- PID prevalence (1)
- PIF pocket (1)
- PKA (1)
- PKCε (1)
- PKD (1)
- PKD/IC (1)
- PLK1 (1)
- PLK1 inhibitors (1)
- PLX4032 (1)
- PLX4720 (1)
- PM (1)
- PMF (1)
- PML (1)
- POLG (1)
- PPAR (Peroxisome proliferator-activated receptors) (1)
- PPARγ (1)
- PRG-1 (1)
- PRLTS3 (1)
- PRNT (1)
- PROM (1)
- PROMISE (1)
- PROTAC (1)
- PRRT2 (1)
- PRoMPT (1)
- PSA (1)
- PTCH (1)
- PTCH-1 (1)
- PTDM (1)
- PTEN (1)
- PTK2B (1)
- PUMA (1)
- PV (1)
- PXA (1)
- PYGL (1)
- Pacemaker (1)
- Paediatric Investigation Plan (1)
- Paediatric oncology (1)
- Paediatric research (1)
- Paediatrics (1)
- Pain management (1)
- Pain sensation (1)
- Pancreas transplantation (1)
- Pancreatic islet (1)
- Pancreatic surgery (1)
- Pancreatitis (1)
- Pancreatoduodenectomy (1)
- Panel testing (1)
- Panic disorder (1)
- Par-4 (1)
- Paracetamol (1)
- Parainfluenza (1)
- Paraneoplastic syndrome (1)
- Parapneumonic pleural effusion (1)
- Parent support (1)
- Parenteral nutrition (1)
- Parkinson (1)
- Parkinsonerkrankung (1)
- Parkinsons disease (1)
- Particles (1)
- Particulate matter (1)
- Patellofemoral Joint (1)
- Pathogen reduction (1)
- Pathogenesis (1)
- Pathologic changes (1)
- Pathological complete response (1)
- Pathologists (1)
- Pathology (1)
- Pathology Section (1)
- Patient Blood Management (1)
- Patient Outcome Assessment (1)
- Patient care planning (1)
- Patient education (1)
- Patient information materials (1)
- Patient isolation (1)
- Patient knowledge (1)
- Patient manikins (1)
- Patient preference (1)
- Patient preferences (1)
- Patient reported outcomes (1)
- Patient safety (1)
- Patient satisfaction (1)
- Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (1)
- Patient-centered care (1)
- Patient-reported outcomes (1)
- Pattern recognition receptors (1)
- Pause (1)
- Pdgfrβ (1)
- Pediatric burn injury (1)
- Pediatric neuroimaging (1)
- Pediatric sarcoma (1)
- Pediatrics (1)
- Pediatrics [MeSH] (1)
- Peer Teaching (1)
- Peer teaching (1)
- Peer-feedback (1)
- Peer-teaching (1)
- Peg3 (1)
- Pegylated liposomal doxorubicin (1)
- Penile carcinomas (1)
- Pentaglobin (1)
- Peptides and proteins (1)
- Percutaneous (1)
- Performing Artists (1)
- Pericardial effusion (1)
- Pericarditis (1)
- Perilymph (1)
- Perimesencephalic (1)
- Periodontal disease (1)
- Periodontal diseases (1)
- Periodontal therapy (1)
- Peripheral vascular disease (1)
- Personalised medicine (1)
- Personalisierte translationale Therapie (1)
- Personality (1)
- Personality disorder (1)
- Pessar (1)
- Petri net (1)
- Pfannenstiel (1)
- Pflege (1)
- Pflegeeinrichtungen (1)
- Pgrmc1 (1)
- Phagocytosis (1)
- Phantom study (1)
- Pharm-fMRI (1)
- Pharmaco-nutrition (1)
- Pharmacodynamic (1)
- Pharmacological treatment (1)
- Pharmacology (1)
- Pharmacometrics (1)
- Pharmacy setting (1)
- Pharmakoepidemiologie (1)
- Pharyngeal reflex (1)
- Phase 2 (1)
- Phase I trials (1)
- Phase II trial (1)
- Phase rotors (1)
- Phase-IV research (1)
- Philadelphia Chromosome (1)
- Philadelphia Chromosome-positive leukemia (1)
- Phospho-soda (1)
- Phospho-tau (1)
- Phospholipids (1)
- Physical activity (1)
- Physical environment (1)
- Physical fitness (1)
- Physical therapist (1)
- Physician report (1)
- Physician-assisted suicide (1)
- Phytochemicals (1)
- Piercing (1)
- Pierre Robin sequence (1)
- Pill Count (1)
- PillCamColon2 (1)
- Pilocytic astrocytoma (1)
- Pim-1 (1)
- Pink esthetic score (1)
- Placental growth factor (1)
- Planning target volume (1)
- Plasma (1)
- Plasma fibronectin (1)
- Plasma transfusion (1)
- Plasma usage (1)
- Plasmacytoid dendritic cell (1)
- Plasminogen (1)
- Plastic endoprosthesis (1)
- Platelet (1)
- Platelet dysfunction (1)
- Platelet lysate (1)
- Platelet releasate (1)
- Platzierung (1)
- Plectin (1)
- Pleural empyema (1)
- Plk1 (1)
- Plus-end (1)
- Pneumococcal conjugate vaccine (1)
- Pneumocystis jirovecii (1)
- Polarity index (1)
- Police (1)
- Poliomyelitis (1)
- Polo-like kinase 3 (1)
- PolySUMOylation (1)
- Polyhexanide (1)
- Polymerase Chain Reaction (PCR) (1)
- Polyphenole (1)
- Polyps (1)
- Polysomnography (1)
- Polyzystisches Ovarsyndrom (1)
- Política de Saúde (1)
- Pooling (1)
- Poor solubility (1)
- Population-based screening (1)
- Porin regulation (1)
- Portal (1)
- Portugal (1)
- Posaconazole serum level (1)
- Position paper (1)
- Positron-emission tomography (1)
- Post surgery pain (1)
- Post treatment (1)
- Post-transplant (1)
- Posterior Cerebral (1)
- Postoperative infections (1)
- Postoperative nutritional management (1)
- Posttranslational modification (1)
- Posttraumatic stress disorder (1)
- Posttraumatische Belastungsstörung (1)
- Posture (1)
- Posture analysis (1)
- Potassium channel Kir2.1 (1)
- Poverty (1)
- Practical training (1)
- Practice (1)
- Practice-based research network (1)
- Praktikum (1)
- Praktische Fertigkeiten (1)
- Pre-economic effects (1)
- Pre-emptive immunotherapy (1)
- Pre-treatment drug resistance mutations (1)
- PreS1 deletion (1)
- Precision (1)
- Precision oncology (1)
- Preclinical (1)
- Preclinical drug development (1)
- Preclinical research (1)
- Precompetitive development (1)
- Predictive medicine (1)
- Predominant polarity (1)
- Preeclampsia (1)
- Prenatal ultrasonographic detection rate (1)
- Preoperative diagnostics (1)
- Preoperative radiochemotherapy (1)
- Prepontine (1)
- Pressure pain (1)
- Presynaptic vesicles (1)
- Preterm birth (1)
- Preventive medicine (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Primary Care Health Centre (1)
- Primary breast lymphoma (1)
- Primary cilium (1)
- Primary health care (1)
- Primary health care [MeSH] (1)
- Primary prophylaxis (1)
- Primary sclerosing cholangitis (1)
- Primärversorgung (1)
- Prisoners (1)
- Prisons (1)
- Probability density (1)
- Probability distribution (1)
- Produkte zur Desinfektion (1)
- Professions (1)
- Profiling Transthiolation Activity (1)
- Profilometry (1)
- Progesteron (1)
- Progesterone (1)
- Prognostic biomarker (1)
- Programming languages (1)
- Prospective randomized Analysis (1)
- Prostaglandin (1)
- Prostate Cancer (1)
- Prostate cancer cell lines (1)
- Prostate-specific membrane antigen (1)
- Prosthetic rehabilitation (1)
- Protease activity (1)
- Proteasomes (1)
- Protective factors (1)
- Protein Kinase Inhibitors (1)
- Protein Structure (1)
- Protein Translocation (1)
- Protein aggregates (1)
- Protein complex (1)
- Protein degradation (1)
- Protein domains (1)
- Protein kinase (1)
- Protein purify derivative (1)
- Protein tyrosine modification (1)
- Protein-Kinasen (1)
- Protein-Protein Interactions (1)
- Proteinkinase (1)
- Proteins (1)
- Proteostasis (1)
- Protestantism (1)
- Prothrombin complex concentrate (1)
- Protokoll-Compliance (1)
- Prototypes (1)
- Proximal humeral fracture (1)
- Präanalytik (1)
- Prädiktive Validität (1)
- Prävalenz (1)
- Prüfung (1)
- Prüfungen (1)
- Prüfungserfolg (1)
- Prüfungsfragen (1)
- Pseudo HE-images (1)
- Psoriasis (1)
- Psoriasis vulgaris (1)
- Psycho-oncology (1)
- Psychodynamic psychotherapy (1)
- Psychological stress (1)
- Psychometric evaluation (1)
- Psychometrics (1)
- Psychopathology (1)
- Psychophysiologie (1)
- Psychosocial (1)
- Public and occupational health (1)
- Publication (1)
- Publication output (1)
- Pulmonary artery pressure (1)
- Pulmonary disease, chronic obstructive (1)
- Pulmonary embolism (1)
- Pulmonary failure (1)
- Pulse contour analysis (1)
- Pulse pressure variation (1)
- Pulsed SILAC (1)
- Pupillometry (1)
- Pustulosis (1)
- Pyruvate (1)
- Pädiatrische Brandverletzung (1)
- QA/QC (1)
- QOL (1)
- Qb-Test (1)
- QbTest® (1)
- Qualitative research (1)
- Qualitative research [MeSH] (1)
- Quality indicators (1)
- Quality management (1)
- Quality of Teaching and Learning (1)
- Quality of health care [MeSH] (1)
- Quality, performance, safety and outcomes (1)
- Qualität (1)
- Qualitätsmanagement (1)
- Qualitätssicherung (1)
- Qualitätssicherung der Lehre (1)
- Quantitative research (1)
- Quantitative sensory testing (1)
- Quantitative trait (1)
- Quantitative trait loci (1)
- Questionnaire (1)
- Questionnaire - Psychometrics - Diagnostics (1)
- Quinine (1)
- Quinolinate phosphoribosyltransferase (1)
- Quinolinic acid (1)
- R (1)
- R programming language (1)
- R software (1)
- RAD001 (1)
- RBC (1)
- RBC-depletion (1)
- RBFOX1 (1)
- RCT (1)
- RD cells (1)
- RDoC (1)
- REM sleep (1)
- REMS (1)
- RH30 cells (1)
- RIP1 (1)
- RMS (1)
- RNA Biology (1)
- RNA extraction (1)
- RNA polymerase (1)
- RNA polymerase inhibitors (1)
- RNA processing (1)
- RNA processing machinery (1)
- RNA therapeutics (1)
- RNA therapy (1)
- RNA viruses (1)
- RNA, long noncoding (1)
- RNA-Interferenz (1)
- RNA-sequencing (1)
- RNA-templated DNA repair (1)
- RNActive (1)
- RNAi (1)
- RNAi and CRISPR screens (1)
- RNAseq analysis (1)
- RNF4 (1)
- ROS generation (1)
- ROS/RNS (1)
- ROS1 (1)
- RPE65 (1)
- RT-qPCR (1)
- RTS (1)
- RUFY (1)
- RULA (1)
- RUNX1/ETO (1)
- Rab proteins (1)
- Rab7 (1)
- Rac1 (1)
- Radial artery (1)
- Radiation exposure (1)
- Radiation induced diarrhoea (1)
- Radical cystectomy (1)
- Radical nephrectomy (1)
- Radiochemotherapy (1)
- Radiofrequency (1)
- Radiology and imaging (1)
- Radiyal arter (1)
- Rahmenbedingungen der Lehre (1)
- Rainfall (1)
- Raman spectroscopy (1)
- Ramón y Cajal (1)
- Random forest (1)
- Randomised controlled trial (1)
- Randomised trial (1)
- Randomized (1)
- Randomized controlled trials (1)
- Randomized trial (1)
- RapL (1)
- Rapamycin (1)
- Rapid diagnostic test (1)
- Rapid eye movement sleep behavior disorder (1)
- Rare Diseases (1)
- Rare disease (1)
- Ratewahrscheinlichkeit (1)
- Rational use (1)
- Re-exploration (1)
- Re-exposure (1)
- Re-injury (1)
- Readmission (1)
- Real-time phase contrast (1)
- Real-world data (1)
- Real-world evidence (1)
- RealTime (1)
- Rearing temperature (1)
- Recall rate (1)
- Receptor physiology (1)
- Reconstructed human epidermis (1)
- Reconstruction (1)
- Reconstructive surgical procedures (1)
- Recurrence (1)
- Recurrence rate (1)
- Red blood cells (1)
- Red yeast rice (1)
- Redox (1)
- Redox modification (1)
- Redox-sensitive GFP (1)
- Reference (1)
- Refractory ALL (1)
- Regenerative medicine (1)
- Regulatory T cells (1)
- Regulatory framework (1)
- Regulatory networks (1)
- Rehabilitation (1)
- Rehospitalization (1)
- Reintervention (1)
- Reisefieber (1)
- Rejection (1)
- Rekonstruktive chirurgische Verfahren (1)
- Relapse (1)
- Relapsed ALL (1)
- Relaxometry (1)
- Release of mtDNA and mtRNA (1)
- Remission (1)
- Remote ischemic conditioning (1)
- Remote monitoring (1)
- Renal cancer (1)
- Renal function (1)
- Renal lesions (1)
- Renal replacement therapy (1)
- Repatriation of corpses (1)
- Reperfusion (1)
- Replication study (1)
- Repositioning drugs (1)
- Reproducibility (1)
- Reproduktionsmedizin (1)
- Research Article (1)
- Research trends (1)
- Reservoir function (1)
- Residential care (1)
- Residential facilities (1)
- Resin composites (1)
- Resource competition (1)
- Respimat® Soft Mist™ Inhaler (1)
- Respiratory Syncytial Virus (1)
- Respiratory infections (1)
- Respiratory signs and symptoms (1)
- Respiratory syncytial virus (1)
- Respiratory tract diseases (1)
- Response (1)
- Response criteria (1)
- Ressourcen (1)
- Restenosis (1)
- Resting state (1)
- Resting-state (1)
- Restricted posture (1)
- Resuscitation (1)
- Reticulon (1)
- Retina (1)
- Retinal degeneration (1)
- Retro-IDEAL (1)
- Retrospective studies (1)
- Return to play (1)
- Return to sports (1)
- Reverse transcription polymerase chain reaction (1)
- Review (1)
- Rezidivrate (1)
- Rheumatology (1)
- Rho GTPases (1)
- Rho/Rho-kinase (1)
- RhoA (1)
- RhoGTPases (1)
- Ribosomal S6 phosphorylation (1)
- Ribosomal translation (1)
- Ribosomes (1)
- Right hemisphere (1)
- Risk assessment (1)
- Risk factor (1)
- Risk factors (1)
- Risk prediction (1)
- Risk reduction (1)
- Risk stratification (1)
- Rivaroxaban (1)
- Robotic Radiosurgery (1)
- Robotic tracking (1)
- Roe deer (1)
- Rolandic Spikes (1)
- Roma women (1)
- Rora (1)
- Roughness (1)
- Round window membrane (1)
- Routinedaten (1)
- Roux-en-Y gastric bypass (1)
- Rtn3 (1)
- Ruijs-Aalfs syndrome (1)
- Rural area (1)
- Rush (1)
- Rush protocol (1)
- Rush-SIT (1)
- Ruxolitinib (1)
- Ryanodine (1)
- S. cerevisiae (1)
- S100 calcium‑binding protein B (1)
- S100b (1)
- S1P lyase (1)
- S1P1 receptor (1)
- S1P1–5 (1)
- S1PR1 (1)
- S1PR4 (1)
- SAGE (1)
- SAH close (1)
- SAMHD1 (1)
- SAMHD1 knockout mouse (1)
- SAMHD1 phosphorylation (1)
- SAP (1)
- SARS coronavirus (1)
- SARS-CoV (1)
- SAVI (1)
- SCA34 (1)
- SCA38 (1)
- SCCHN (1)
- SCMR (1)
- SCT (1)
- SDF-1 (1)
- SDH (1)
- SDS (1)
- SENP (1)
- SENP6 (1)
- SERS (1)
- SF-36 (1)
- SHH (1)
- SIADH (1)
- SILAC (1)
- SIRT1 (1)
- SKI II (1)
- SLC20A1 (1)
- SLP-76 (1)
- SMAD (1)
- SMAD signaling (1)
- SNP (1)
- SOCS (1)
- SOD (1)
- SOFA (1)
- SPARTAN (1)
- SPRTN (1)
- SPSS (1)
- SR protein (1)
- SR-BI (1)
- SRSF3 (1)
- SRSF7 (1)
- ST2L (1)
- STAMPE2 (1)
- STAT1 (1)
- STAT5 (1)
- STDP (1)
- STIR (1)
- SUMO (1)
- SUMO chains (1)
- SUMO1-3 (1)
- SUMOylation (1)
- SUN1 (1)
- SUN2 (1)
- SUV (1)
- SVR (1)
- SW480 Cell (1)
- SW480 cells (1)
- SWATH (1)
- Saccades (1)
- Saccadometry (1)
- Safety equipment (1)
- Safety learning (1)
- Salivary gland diseases (1)
- Salmonella choleraesuis (1)
- Salmonella infection (1)
- Salt inducible kinase 2 (SIK2) (1)
- Salvage therapy (1)
- Sarcomas (1)
- Sarcopenia (1)
- Sarkoidose (1)
- Sauerstoffpartialdruck (1)
- Scedosporium spp. (1)
- Scheimpflug imaging (1)
- School support (1)
- Science structure (1)
- Scientifi c competence (1)
- Scientific community (1)
- Scientific publishing (1)
- Scientometria (1)
- Scientometric analysis (1)
- Scientometrics (1)
- Scientometry (1)
- Sclerostin (1)
- Screening guidelines (1)
- Seattle heart failure model (1)
- Second stage of labor (1)
- Second-line treatment (1)
- Secondary injury cascades (1)
- Secondary prevention (1)
- Secretion (1)
- Seizure (1)
- Seizures (1)
- Selection bias (1)
- Selective autophagy (1)
- Selenium (1)
- Selenium administration in gynecologic radiation oncology (1)
- Selenoproteins (1)
- Self-assessment (1)
- Self-efficacy (1)
- Self-expandable metal stent (SEMS) (1)
- Self-expandable metal stents (1)
- Self-expandable metal stents complications (1)
- Self-management support (1)
- Self-myofascial release (1)
- Self-renewal (1)
- Self-report (1)
- Seltene Erkrankungen (1)
- Semicontinuous (1)
- Semitendinosus tendon autograft (1)
- Sensitivity (1)
- Sensorimotor processing (1)
- Sensorimotor training (1)
- Sensory Neuroscience (1)
- Sensory neuron (1)
- Sensory perception (1)
- Sensory systems (1)
- Sepsis-bundle (1)
- Septic shock (1)
- Sequence (1)
- Sequence alignment (1)
- Sequence motif analysis (1)
- Sequential (1)
- Seribantumab (1)
- Serine proteases (1)
- Seroconverter (1)
- Seroepidemiology (1)
- Seroprevalence (1)
- Serotype 3 (1)
- Serum (1)
- Serum Susceptibility (1)
- Severe Acute Respiratory Syndrome (1)
- Severe bacterial infection (1)
- Severe blood loss (1)
- Severe malaria (1)
- Severity of illness index (1)
- Sex (1)
- Sexual Dysfunctions (1)
- Sexual child abuse (1)
- Sexual violence (1)
- Sexualmedizin (1)
- Sexuelle Dysfunktionen (1)
- Sexuelle Gewalt (1)
- Sexuelle Revolution (1)
- Sexueller Kindesmissbrauch (1)
- Shannon index (1)
- Sharpin (1)
- Sholl analysis (1)
- Shone’s complex (1)
- Short bowel syndrome (1)
- Shoulder joint (1)
- Shunt (1)
- Sickle Cell Disease (1)
- Signal Transduction (1)
- Signal transduction (1)
- Signaling ROS (1)
- Signaling pathway (1)
- Silicosis (1)
- Silver in situ hybridization (1)
- Simulation and modeling (1)
- Simulation komplexer Systeme (1)
- Simulation training (1)
- Simultaneous (1)
- Single-Molecule Localization Microscopy (SMLM) (1)
- Single-cell RNA-seq (1)
- Single-cell RNA-sequencing (1)
- Sistemas de Saúde (1)
- Skeletal muscle (1)
- Skills training (1)
- Skin fibroblast (1)
- Skin irritation test (1)
- Skin manifestation (1)
- Skin morphology (1)
- Skp (1)
- Slc11a2 (1)
- Slc25a37 (1)
- Sleep deprivation (1)
- Smac mimetic (1)
- Small bowel (1)
- Small bowel atresia (1)
- Small bowel endoscopy (1)
- Small molecules (1)
- Small- and medium-sized enterprises (1)
- Small-cell lung cancer (1)
- Smart nebulizer (1)
- Smoking habits (1)
- Smooth muscle (1)
- Smooth muscle cell (1)
- Snakebite (1)
- Social Media (1)
- Social communication (1)
- Social epidemiology (1)
- Social health determinants (1)
- Social information processing (1)
- Social phobia (1)
- Social research (1)
- Social sciences (1)
- Social skills training (1)
- Social support (1)
- Socio-economic analysis (1)
- Soft skills (1)
- Soft tissue infection (1)
- Soft-tissue sarcoma (1)
- Software tool (1)
- Software tools (1)
- Solidworks 2015 (1)
- SoloSTAR (1)
- Somatization (1)
- Sonication (1)
- Source reconstruction (1)
- Sozialpsychiatrischer Dienst (1)
- Spa water (1)
- Spanish National Health System (1)
- Species identification (1)
- Speciesidentification (1)
- Specimen preparation and treatment (1)
- Spectral library (1)
- Spectraldomain OCTA (1)
- Spectrin (1)
- Speech (1)
- Speech signal processing (1)
- Sphere Formation Assay (1)
- Sphingolipid (1)
- Sphingosine 1-phosphate (1)
- Sphingosine-1-phosphate (1)
- Spinal cord (1)
- Spine Register (1)
- Spine density (1)
- Spinocerebellar ataxia (1)
- Spirochetes (1)
- Splanchnic Hemodynamics (1)
- Spleen (1)
- Splenic dendritic cell (1)
- Splice variants (1)
- Spondyloarthritis (1)
- Spondylolisthesis (1)
- Spontaneous bacterial peritonitis (1)
- Sports (1)
- Spot sign (1)
- Squamous cell carcinoma (1)
- StUbL (1)
- Staatsexamen (1)
- Standard risk (1)
- Standardized operating procedures (1)
- Standards of care (1)
- Standardverfahren (1)
- Staphylococcus aureus (1)
- Starvation (1)
- Statistical methods (1)
- Status epilepticus (1)
- Stavudine (1)
- Steatosis (1)
- Stenosis (1)
- Stenotrophomonas maltophilia (1)
- Stentoplasty (1)
- Sterblichkeit (1)
- Stereotactic radiosurgery (1)
- Steroid (1)
- Stilbene (1)
- Stimulation experiments (1)
- Stimulus-secretion coupling (1)
- Stoma (1)
- Stress (1)
- Stress and resilience (1)
- Stress resilience (1)
- Striatum (1)
- Stringed bow player (1)
- Stroke prevention (1)
- Stroke volume variation (1)
- Stromal cell (1)
- Structural MRI (1)
- Structural genomics (1)
- Structured reporting (1)
- Strukturwandel der Sexualität (1)
- Students (1)
- Studiendauer (1)
- Studium mit Kind (1)
- Störfaktoren (1)
- Sub-segmentation (1)
- Subacute cerebellar degeneration (1)
- Subarachnoid Hemorrhage (1)
- Subcutaneous (1)
- Subgroup identification (1)
- Subpopulation (1)
- Substances for disinfection (1)
- Subterranean (1)
- Sudden cardiac death (1)
- Suicidal behavior (1)
- Suicidal ideation (1)
- Suicidal thoughts (1)
- Sulfasalazine (1)
- Sulfhydryl-reactivity (1)
- Sulfur metabolism (1)
- Sumatra (1)
- Superimposition (1)
- Superinfection (1)
- Supplemental parenteral nutrition (1)
- Supplementation (1)
- Supraspinatus tendon (1)
- Supraventricular arrhythmias (1)
- Surface (1)
- Surgical ICU (1)
- Surgical risk (1)
- Surgical site occurrence (1)
- Surveillance (1)
- Surveys (1)
- Survival data (1)
- Sustainable Development (1)
- Sustained virological response (SVR) (1)
- Sweat osmolality (1)
- Sweat secretion rate (1)
- Swept-source OCTA (1)
- Switzerland (1)
- Sycamore (1)
- Syllables (1)
- Sympathicolysis (1)
- Symptome (1)
- Symptoms (1)
- Synapses (1)
- Synaptic dysfunction (1)
- Synaptopodin (1)
- Syncope (1)
- Syndrome des ovaires polykystiques (1)
- Synovial inflammation (1)
- Synovial sarcoma (1)
- Synthetic (1)
- Systematic review (1)
- Systemic inflammatory response (1)
- Systemic lupus erythematosus (1)
- Systemic treatment (1)
- Systems biology (1)
- Systems medicine (1)
- T Cells (1)
- T cell receptors (1)
- T cell/histiocyte rich large B cell lymphoma (1)
- T helper 17 cells (1)
- T-ALL (1)
- T-DM1 (1)
- T-cell homeostasis (1)
- T-cell homing (1)
- T-cell niche (1)
- T-cell receptor (1)
- T-cell targeting (1)
- T-cells (1)
- T-lymphocytes (1)
- T-tubule system (1)
- T1 (1)
- T1 and T2 mapping (1)
- T1 mapping (1)
- T84 colon carcinoma cells (1)
- TACE (1)
- TALE-homdomain protein (1)
- TAPSE (1)
- TAVI (1)
- TAVR (1)
- TAX1BP1 (1)
- TBK1 (1)
- TC stenosis (1)
- TCR signaling cascade (1)
- TEER (1)
- TEM (1)
- TEVAR (1)
- TG-186 (1)
- TG-43 (1)
- TGF-beta (1)
- TGF-β (1)
- TGF-β1 (1)
- THV (1)
- TIA-1 (1)
- TIC10 (1)
- TILs (1)
- TIM23 (1)
- TIMP2 (1)
- TL AOSIS (1)
- TLR (1)
- TLR2/6 (1)
- TLR7 (1)
- TLR8 (1)
- TMC435 (1)
- TMEM126B (1)
- TMS (1)
- TMS-EEG (1)
- TMT (1)
- TNF (1)
- TNF inhibitors (1)
- TNF-α (1)
- TNFR1 (1)
- TOR inhibitor (1)
- TOR1A (1)
- TP53 (1)
- TP53 mutation status (1)
- TP53-induced glycolysis and apoptosis regulator (1)
- TPR (1)
- TRAPP (1)
- TRIM25 (1)
- TRPA1 (1)
- TSC (1)
- TSC-associated neuropsychiatric disorders (1)
- TSC22D3 (1)
- TVT (1)
- TWINKLE (1)
- Tabakkonsum (1)
- Tagging (1)
- Tailored medicine (1)
- Tailored therapy (1)
- Tamponade (1)
- Targeted therapies (1)
- Targeted tumor therapy (1)
- Tas2r126 (1)
- Tas2r135 (1)
- Tas2r143 (1)
- Tattoo (1)
- Tau (1)
- Tau acetylation (1)
- Tax effect (1)
- Taxane (1)
- Taxonomy (1)
- Tea (1)
- Teaching and Learning conditions (1)
- Technicians (1)
- Technique (1)
- Telemedicine (1)
- Telomere length (1)
- Telomeres (1)
- Temozolomide (1)
- Temporal lobe epilepsy (1)
- Temsirolimus (1)
- Tendon incontinence repair (1)
- Tendon transplantation (1)
- Term birth (1)
- Testosterone (1)
- Tet-inducible system (1)
- Texture analysis (1)
- Tfrc (1)
- Tgfβ (1)
- Th1 polarization (1)
- Theft (1)
- Theorie der Sexualität (1)
- Therapeutics (1)
- Therapy response (1)
- Thermal injury (1)
- Thermal spring water (1)
- Thermische Verletzung (1)
- Thermodilution (1)
- Thermoplasma (1)
- Thiol redox modification (1)
- Three-dimensional back scan (1)
- Three-dimensional echocardiography (1)
- Thrombosis/hypercoagulable states (1)
- Thrombotic microangiopathy (1)
- Thrombotic thrombocytopenic purpura (1)
- Thromboxane (1)
- Thymocytes (1)
- Thymus (1)
- Thyroid (1)
- Thyroid disease (1)
- Tick (1)
- Tick-Borne diseases (1)
- Tick-borne encephalitis (1)
- Ticks (1)
- Time in therapeutic range (TTR) (1)
- Time optimization (1)
- Time series (1)
- Time to treatment failure (1)
- Timing (1)
- Tinnitus (1)
- Tissue microarray (TMA) (1)
- Tissue stiffness (1)
- Toll-like receptor (TLR) 6 (1)
- Toll-like receptors (1)
- Tomography (1)
- Tonsil (1)
- Tools and ressources (1)
- Tooth transplantation (1)
- Topoisomerase (1)
- Total colonoscopy (1)
- Total hip replacement (1)
- Total operating room time (1)
- Toxicology (1)
- Tozasertib (1)
- Tracheal Intubation (1)
- Tranexamic acid (1)
- Transcatheter Aortic Valve Implantation (1)
- Transcatheter based aortic valve implantation (1)
- Transcription (1)
- Transcriptional control (1)
- Transcriptome (1)
- Transcriptome analysis (1)
- Transcriptome microarray (1)
- Transduction (1)
- Transesophageal echocardiography (1)
- Transfer model (1)
- Transferases (1)
- Transformation (1)
- Transgender (1)
- Transgenic SK-2 mice (1)
- Transient (1)
- Transient elastography (1)
- Transient ischemic attack (1)
- Transition invariant (1)
- Transitional cell carcinoma (1)
- Translation initiation (1)
- Translational (1)
- Transmembrane communication (1)
- Transplantation (1)
- Transportation (1)
- Trastuzumab (1)
- Trauma surgery (1)
- Traumatic brain injury (1)
- Travellers (1)
- Treatment modification (1)
- Treatment protocol (1)
- Trees (1)
- Treg cell (1)
- Triamcinolone acetonide (1)
- Trichuris suis ova (1)
- Triple negative (1)
- Triple therapy (1)
- Triple-negative breast cancer (1)
- Trk (1)
- TrkC (1)
- Tropenmedizin (1)
- Troponin (1)
- Trousseau’s syndrome (1)
- Trueness (1)
- Tubers (1)
- Tularemia (1)
- Tumor growth (1)
- Tumor heterogeneity (1)
- Tumor infiltrating lymphocytes (1)
- Tumor interstitial fluid pressure (1)
- Tumor obstruction (1)
- Tumor suppressor protein (1)
- Tumor volume (1)
- Tumormarker (1)
- Tumorsphere Formation (1)
- Tumour biomarkers (1)
- Tumour immunology (1)
- Turkish (1)
- Tween20 (1)
- Twist (1)
- Two-hit hypothesis (1)
- Type 2 Diabetes mellitus (1)
- Type 2 diabetes (1)
- Tyrosine kinase inhibitor (1)
- Tyrosine kinase inhibitor mTOR inhibition (1)
- Tyrosine kinases (1)
- U-87MG (1)
- UDP-glucose ceramide glycosyltransferase (1)
- UGCG (1)
- ULBP4 (1)
- UPPS (1)
- USP9X (1)
- UVA (1)
- UWB diagnostics (1)
- Ubiquitin (1)
- Ubiquitin Ligase (1)
- Ubiquitin kinase PINK1 (1)
- Ubiquitylation (1)
- Ultra microscopy (1)
- Ultra-rush protocol (1)
- Ultrasonic nebulizer (1)
- Ultrasound imaging (1)
- Umbilical cord (1)
- Underfeeding (1)
- Undergraduate medical education (1)
- Undergraduate training (1)
- Undergraduates (1)
- Unilateral hip osteoarthritis (1)
- United States (1)
- União Européia (1)
- Unterdruckwundtherapie (1)
- Upper body posture (1)
- Upper respiratory tract infection (1)
- Urban (1)
- Ureter (1)
- Urethral cancer (1)
- Urothelial cancer (1)
- Urothelial carcinoma (1)
- Urothelial cells (1)
- Urticaria (1)
- Usutu virus (1)
- Uveal melanoma (1)
- V4 (1)
- VARGADO (1)
- VASP (1)
- VBM (1)
- VE-cadherin (1)
- VEGF receptors (1)
- VEGFA (1)
- VEGFR (1)
- VEGFR-2 (1)
- VEGFR-3 (1)
- VHH (1)
- VIP (1)
- VIP1 (1)
- VIS (1)
- VISTA (1)
- VLA4 (1)
- VPA-analogues (1)
- VPAC1 (1)
- VRE (1)
- VX680 (1)
- Vaccination breakthrough (1)
- Vaccine (1)
- Vaccine breakthrough (1)
- Vacuoles (1)
- Vaginal breech delivery (1)
- Vaginal delivery (1)
- Validierungsstudie (1)
- Validity (1)
- Value-added effect (1)
- Variant histology (1)
- Vascular biology (1)
- Vascular emergencies (1)
- Vascular endothelial growth factor A (1)
- Vascular endothelial growth factor receptor 2 (1)
- Vascular permeability (1)
- Vasculogenesis (1)
- Vector mosquito (1)
- Vector-borne infections (1)
- Vein (1)
- Veino-lymphatic separation (1)
- Vemurafenib (1)
- VeroE6‐eGFP cells (1)
- Versorgungsforschung (1)
- Versorgungsstrukturen (1)
- Vertebral augmentation (1)
- Vertebral body stenting (1)
- Vertebral fracture (1)
- Vertigo (1)
- Veränderungsmanagement (1)
- Vespid venom allergy (1)
- Victimization (1)
- Video-oculography (1)
- Videolaryngoscopy (1)
- Vincristine (1)
- VirB (1)
- Viral Load (1)
- Viral core (1)
- Viral infection (1)
- Viral replication (1)
- Virchow-Robin Spaces (1)
- Virological Failure (1)
- Virological Response (1)
- Virological failure (1)
- Virotherapy (1)
- Virtual implant planning (1)
- Visual impairments (1)
- Visual quality (1)
- Visual system (1)
- Vitamin (1)
- Vitamin K antagonists (1)
- Vitreous opacity (1)
- Vitreous samples (1)
- Voltage attenuation (1)
- Volume overload (1)
- Volumetric analysis (1)
- Volumetric indexes (1)
- Voriconazole (1)
- Vorkenntnisse (1)
- Vorklinik (1)
- Voxel-based morphometry (1)
- WNT (1)
- WRNIP1 (1)
- WT1 (1)
- WYE-354 (1)
- Wait and see (1)
- Wakefulness (1)
- Water chemistry (1)
- Weak bases (1)
- Wearable cardioverter‐defibrillator (1)
- Web 2.0 (1)
- Weight loss (1)
- West Nile fever (1)
- West Nile neuroinvasive disease (1)
- West Nile virus (1)
- Westphal-Paradigm (1)
- White blood cells (1)
- Whole genome association (1)
- Willensfreiheit (1)
- Wilms tumor (1)
- Wing morphometry (1)
- Wnt (1)
- WoMo score (1)
- Women in medicine (1)
- Women in science (1)
- Work shadowing (1)
- Workplace (1)
- Workplace ergonomics (1)
- Wound healing potential (1)
- X-ray Crystallography (1)
- X-ray crystallography (1)
- XL probe (1)
- Xenorhabdus (1)
- YB-1 (1)
- YK-4-279 (1)
- YM155 (1)
- YWHAE (1)
- YWHAZ (1)
- Yarrowia lipolytica (1)
- Yarrowia lipolytica mitochondrial genome complex I NADH: ubiquinoneoxidoreductase (1)
- Yellow fluorescent protein (1)
- Zebrafish (1)
- Zellbiologie (1)
- Zellulärer Transport (1)
- Zervixverkürzung (1)
- Zika (1)
- Zika fever (1)
- Zika vaccine (1)
- Zirconia (1)
- Zoopotentation (1)
- Zooprophylaxis (1)
- Zulassung zum Medizinstudium (1)
- Zulassungskriterien (1)
- Zwangseinweisungen (1)
- a disintegrin and metalloprotease 10 (ADAM10) (1)
- abdominal imaging (1)
- abemaciclib (1)
- ablation (1)
- ablation techniques (1)
- abnormal tumor vasculature (1)
- abuso (1)
- academic (1)
- academic medicine (1)
- acceptable change limit (1)
- accident (1)
- accidental falls [MeSH] (1)
- accidents (1)
- acetylation (1)
- acetylcholine binding protein (1)
- acetylcholine receptors (1)
- acetylcholinesterase (1)
- acetylcholinesterase (AChE) inhibition (1)
- acetylcholinesterase inhibition (1)
- acid dentine lysate (1)
- acid sphingomyelinase (ASMase; Smpd1) (1)
- acneiform skin toxicity (1)
- acoustic radiation force impulse imaging (1)
- acquired drug resistance (1)
- actin cytoskeleton (1)
- actin dynamics (1)
- action sounds (1)
- action-effect association (1)
- activation receptors (1)
- active/deactive transition (1)
- activities of daily life (1)
- activity-based benefits (1)
- actography (1)
- acupuncture (1)
- acute and chronic graft versus host disease (a/c GVHD) (1)
- acute attacks (1)
- acute cholecystitis (1)
- acute chronic inflammation (1)
- acute coronary syndromes (1)
- acute decompensation of cirrhosis (1)
- acute exacerbations of COPD (1)
- acute inflammation (1)
- acute leukemia (1)
- acute liver failure (1)
- acute liver injury (1)
- acute lung injury (ALI) (1)
- acute lymphatic leukemia (1)
- acute lymphoblastic leukaemia (1)
- acute myeloid leukemia (AML) (1)
- acute respiratory distress syndrome (1)
- acute-on-chronic liver failure (ACLF) (1)
- acute‐on‐chronic liver failure (1)
- adaptation plan (1)
- adaptive cardiac remodelling (1)
- adaptive immune escape (1)
- adaptive immunity (1)
- adeno-associated virus (1)
- adenocarcinoma (1)
- adenomatous polyposis (1)
- adenosine receptors (1)
- adeno‐associated virus (1)
- adipocytes (1)
- adiponectin (1)
- adipose tissue (1)
- adipose tissue-derived stem cell (1)
- adipose-derived stem cells (1)
- adipose-derived stem cells (ASCs) (1)
- adiposity (1)
- adjustment disorder (1)
- adjuvant chemotherapy (1)
- adjuvant radiotherapy (1)
- admission criteria (1)
- adolescence (1)
- adolescentes (1)
- adolescents’ health (1)
- adoptive cell therapy (1)
- adoptive immunotherapy (1)
- adrenal insuffciency (1)
- adrenoceptors (1)
- adult and elderly patients (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adult congenital heart disease (1)
- adult neurogenesis (1)
- advance directive (1)
- advanced breast cancer (1)
- advanced glycation end products (1)
- adverse effects (1)
- adverse events (1)
- aerobic exercise (1)
- aerodynamics (1)
- aerosol (1)
- aesthetics (1)
- affective disorder (1)
- affective disorders (1)
- affinity purification (1)
- affordance (1)
- aftercare structures (1)
- aged [MesH] (1)
- aggressiveness (1)
- agonists (1)
- air pollution (1)
- air pouch (1)
- airborne bacteria (1)
- airway (1)
- airway remodeling (1)
- alcohol dehydrogenase (ADH) (1)
- alcohol metabolism (1)
- alcohol use disorder (1)
- alcoholic liver disease (1)
- alcoholic liver injury (1)
- aliphatic halogenated hydrocarbons (1)
- alkaloid (1)
- all-ceramic (1)
- alleles (1)
- allergen immunotherapy (1)
- allergic rhinitis (1)
- allergy (1)
- alloHSCT (1)
- allocation (1)
- allogeneic (1)
- allogeneic hematopoietic stem cell transplantation (1)
- allogeneic hematopoietic stem cell transplantation (aHSCT) (1)
- allogeneic transplantation (1)
- allosteric inhibition (1)
- allosteric regulation (1)
- alpha band (1)
- alpha peak (1)
- alpha-synuclein (1)
- alpharetroviral vector (1)
- alpinia zerumbet (1)
- alternative 3′ end processing (1)
- alternative oxidase (1)
- alveolar macrophages (1)
- alzheimer disease (1)
- ambiguity (1)
- amblyopia (1)
- ameloblastoma (1)
- amino acid PET (1)
- amino acids (1)
- amlexanox (1)
- amoeboid (1)
- amoxicillin/metronidazole (1)
- amphiregulin (1)
- amygdala (1)
- amyloid beta-peptides (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaesthesia in orthopaedics (1)
- anaesthetics (1)
- anal carcinoma (1)
- analgesia based sedation (1)
- anaphylactic reactions (1)
- anaplastic large cell lymphoma (1)
- anastomotic leakage (1)
- anatomy (1)
- anatomy and histology (1)
- anemia (1)
- anesthesiology (1)
- angio-immunogenic switch (1)
- angiography (1)
- angioplasty (1)
- angiopoietin-2 (1)
- angiopoietin-like 3 (ANGPTL3) (1)
- angiopoietins (1)
- angiostasis (1)
- animal host (1)
- animal model (1)
- anisotropy (1)
- annual bleeding rate (1)
- anorexia nervosa (1)
- anoxygenic phototrophic sulfur bacteria (1)
- antenatal characteristics (1)
- antenatalne značilnosti (1)
- anterior chamber depth changes (1)
- anti-GD2 immunotherapy (1)
- anti-cancer therapy (1)
- anti-chronic myeloid leukemia (1)
- anti-citrullinated protein antibodies (1)
- anti-diabetes (1)
- anti-epileptic drug (1)
- anti-inflammatory (1)
- anti-inflammatory agents (1)
- anti-inflammatory effects (1)
- anti-retroviral agents (1)
- anti-skin aging (1)
- anti-tumor activity (1)
- antibiotic (1)
- antibiotic treatment (1)
- antibody (1)
- antibody tests (1)
- anticancer agents (1)
- anticholinergic burden (1)
- anticoagulants (1)
- anticoagulation (1)
- anticonvulsant (1)
- anticonvulsant activity (1)
- antidepressants (1)
- antiepileptic drug (1)
- antifibrotic therapy (1)
- antifungal activity (1)
- antifungal combination therapy (1)
- antifungal host response (1)
- antifungal management (1)
- antifungal prophylaxis (1)
- antifungal therapy (1)
- antigen (1)
- antigenic variation (1)
- antigens of infectious origin (1)
- antihormone therapy (1)
- antimicrobial activity (1)
- antioxidant (1)
- antioxidant activity (1)
- antioxidant defense (1)
- antiproliferative activity (1)
- antireflux surgery (1)
- antiresorptive agents (1)
- antiseizure (1)
- antisense oligonucleotides (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antitumor immunity (1)
- antiviral drugs (1)
- antiviral peptide (1)
- anxiety (1)
- apical junction (1)
- apigenin (1)
- apixaban (1)
- apparent diffusion constant (1)
- apparent motion (1)
- apps (1)
- aprotinin (1)
- aptamer (1)
- aquaporin 1 (1)
- aquaporin-4 (AQP4) antibody (1)
- arachidonate 15-lipoxygenase (1)
- arachidonic acid (1)
- archaea (1)
- archaeosomes (1)
- architecture (1)
- arm (1)
- aromatics (1)
- arsenic trioxide (1)
- arterial hypertension (1)
- artery (1)
- artesunate (ART) (1)
- articulatory motor cortex (1)
- artificial neural networks (1)
- aspirin (1)
- assay development (1)
- assessment (1)
- associative memory (1)
- asthma phenotypes (1)
- astrocyte (1)
- astrocyte heterogeneity (1)
- astroglia (1)
- asymmetric hearing (1)
- asymptomatic (1)
- ataxia score (1)
- athletes (1)
- athletic training (1)
- atopy (1)
- atrial septostomy (1)
- atrophy (1)
- attachment loss (1)
- attention deficit hyperactivity disorder (1)
- attention modulation (1)
- attention-deficit/hyperactivity disorder (1)
- attention-deficit/hyperactivitydisorder (1)
- attractiveness (1)
- auditory cortex (1)
- auditory development (1)
- auditory language processing (1)
- auditory prediction (1)
- auditory system (1)
- augmentation materials (1)
- authentication (1)
- authorship (1)
- autism (1)
- autistic disorder (1)
- auto-structure (1)
- autoantibodies (1)
- autoantigen (1)
- autograft (1)
- autoimmune encephalomyelitis (1)
- autoimmune polyglandular syndrome type 2 (1)
- autoimmune thyroiditis (1)
- automated patch-clamp (1)
- automatic environmental tobacco smoke emitter (1)
- automation (1)
- autophagic cell death (1)
- autopsy (1)
- autoreactivity (1)
- autovaccine (1)
- avelumab (1)
- aviscumine (1)
- axon (1)
- azaindole (1)
- b-cell lymphomas (1)
- back pain (1)
- back scan (1)
- bacteria (1)
- bacterial translocation (1)
- bacterium (1)
- baicalein (1)
- balanced state (1)
- balloon pulmonary angioplasty (1)
- baroreflex (1)
- barriers to implementation (1)
- basal cell carcinoma (1)
- basal insulin (1)
- basic leucine zipper transcription factor ATF-like (1)
- basic mechanisms (1)
- basonuclin 2 (1)
- beads (1)
- beam quality correction factors (1)
- behavioral adverse events (1)
- behavioral performance (1)
- belimumab (1)
- bendamustine (1)
- berotralstat (1)
- beta band (1)
- beta blockade (1)
- betamethasone dipropionate (1)
- beta‐trace protein (1)
- bibliometric analysis (1)
- bicuspid aortic valve (1)
- biglycan (1)
- bile duct stenosis (1)
- biliary cirrhosis (1)
- binary search procedure (1)
- binaural cochlear implants (1)
- binding (1)
- bio imaging (1)
- bio-absorbable mesh (1)
- bioacoustics (1)
- bioactive phospholipids (1)
- bioactive phytochemicals (1)
- bioactivity (1)
- biobank (1)
- biochanin A (1)
- biochemical recurrence (1)
- biochemistry (1)
- bioenergetics (1)
- biofilm (1)
- biokompatibilni materijali (1)
- biological maturation (1)
- biological mesh (1)
- biological transport (1)
- biological treatments (1)
- biologically inspired computing (1)
- biologicals (1)
- bioluminescence (1)
- biomarker study (1)
- biomechanics (1)
- biopsy naïve (1)
- bipolar disorders (1)
- birch pollen allergoid (1)
- bistable (1)
- bladder cancer (1)
- bladder cancer (BCa) (1)
- bladder dose (1)
- bladder exstrophy-epispadias complex (1)
- blastic plasmacytoid dendritic cell neoplasm (1)
- blended learning (1)
- bleomycin (1)
- blood consumption (1)
- blood donor (1)
- blood flow recovery (1)
- blood hiv rna (1)
- blood loss (1)
- blood safety (1)
- blood transfusion (1)
- blood-brain barrier (1)
- blood-cerebrospinal fluid barrier (1)
- blow flies (1)
- blow fly (1)
- bmal1 (1)
- body dysmorphic disorder (1)
- body plethysmography (1)
- body posture (1)
- bone (1)
- bone chips (1)
- bone damage (1)
- bone loss (1)
- bone marrow (1)
- bone marrow derived mononuclear cells (1)
- bone marrow metastasis (1)
- bone marrow microenvironment (1)
- bone marrow mononuclear cells (1)
- bone metastasis (1)
- bone morphogenetic protein-2 (1)
- bone morphogenetic proteins (BMPs) (1)
- bone regeneration (1)
- bone substitute material (1)
- bone substitutes (1)
- bone tissue regeneration (1)
- bone-marrow (1)
- bone‐screw (1)
- bone–implant interface (1)
- borrelia mayonii (1)
- bortezomib (1)
- bottom-up (1)
- brachytherapy imaging methods (1)
- brain anatomy (1)
- brain function (1)
- brain injury (1)
- brain metastasis (1)
- brain networks (1)
- brain oscillations (1)
- brain phosphorylome (1)
- brain structure (1)
- brain tumor (1)
- brainmass (1)
- brainsize (1)
- branched-chain amino acids (BCAA) (1)
- breakpoint cluster region (1)
- breast cancer diagnosis (1)
- breast cancer systemic therapy (1)
- breast cancer treatment (1)
- breech (1)
- broad-range qPCR (1)
- broadly neutralizing antibodies (1)
- bronchial allergen challenge (1)
- bronchial allergen provocation (1)
- bronchiolitis obliterans syndrome (1)
- bronchodilator (1)
- buccal mucosa (1)
- buccal mucosal graft urethroplasty (1)
- bulimia nervosa (1)
- bullying (1)
- bundle (1)
- butyrylcholinesterase (1)
- c-kit (1)
- c1orf124 (1)
- cBioPortal (1)
- cFLIP (1)
- cGAS-STING (1)
- cHL (1)
- cIAP1 (1)
- cIAP1 BIR (1)
- cIAP1/2 (1)
- cadherin (1)
- calbindin (1)
- calcification score (1)
- calcipotriol (1)
- calcium handling (1)
- calcium-independent phospholipase A2β (1)
- calcium-sensor (1)
- callous-unemotional traits (1)
- caloric restriction (1)
- calprotectin (1)
- calretinin-knock out (1)
- cancer and drug vulnerabilities (1)
- cancer care (1)
- cancer care providers (1)
- cancer cell malignancy (1)
- cancer cell metabolism (1)
- cancer cells (1)
- cancer drug (1)
- cancer immunobiology (1)
- cancer patients (1)
- cancer screening (1)
- cancer therapy (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- candidate genes (1)
- candidemia (1)
- cannabidiol (1)
- cannabinoid receptor type 1 (1)
- cannabinoids (1)
- cannabis (1)
- canonical (1)
- canonical/non-canonical (1)
- cap-dependent translation (1)
- car indoor (1)
- carbapenem resistance (1)
- carbapenem-resistant Gram-negative bacteria (CRGN) (1)
- carbon oxides (COx) (1)
- carbon tetrachloride (1)
- carboxyfluorescein (1)
- carcinoma (1)
- cardiac I/R injury (1)
- cardiac arrest (1)
- cardiac events (1)
- cardiac ischaemia‐reperfusion (1)
- cardiac magnetic (1)
- cardiac myocytes (1)
- cardiac rehabilitation (1)
- cardiomegaly (1)
- cardiomyopathy (1)
- cardiovascular diseases (1)
- cardiovascular magnetic resonance (1)
- cardiovascular pharmacology (1)
- cardiovascular precision medicine (1)
- cardiovascular risk factors (1)
- career promotion (1)
- caregivers (1)
- carnitine supplementation (1)
- carotid (1)
- carpal tunnel syndrome (1)
- carrion (1)
- cartilage oligomeric matrix protein (1)
- cartilage trauma (1)
- case reports (1)
- case study (1)
- case-control study (1)
- caspase 8 (1)
- caspase-1 (1)
- cataract surgery (1)
- catheter (1)
- catheter removal (1)
- catheterization/diagnostic interventional (1)
- causality assessment (1)
- cd4 count determination procedure (1)
- cdk (1)
- cdk2/cyclin A (1)
- ceRNA (1)
- celery (1)
- celiac desease (1)
- cell adhesion (1)
- cell and focal adhesion (1)
- cell cycle (1)
- cell cycle arrest (1)
- cell cycling (1)
- cell fate (1)
- cell fusion (1)
- cell growth (1)
- cell identity (1)
- cell line (1)
- cell salvage (1)
- cell signaling (1)
- cell survival (1)
- cell survival mechanisms (1)
- cell transplantation (1)
- cellular immunology (1)
- cellular reaction (1)
- cellular response (1)
- cellular signalling (1)
- cellular therapy (1)
- centenarians (1)
- central nervous system (1)
- central nervous system infection (1)
- centrifugation (1)
- ceramide synthase (CERS2/CERS1) (1)
- cerclage (1)
- cerebellar mutism (1)
- cerebello-dentato-thalamo-cortical pathway (1)
- cerebral infarct (1)
- cerebral radiation necrosis (1)
- cerebrovascular disease (1)
- ceritinib (1)
- cervical shortening (1)
- cervical spine (1)
- cervico-thoracic junction (1)
- cetuximab-bevacizumab therapy sequence (1)
- ch14.18/CHO (1)
- chamomile (1)
- changes immune activation (1)
- chaperones (1)
- characterization (1)
- charged particles (1)
- checklist (1)
- checkpoint inhibition (1)
- checkpoint proteins (1)
- chelation therapy (1)
- chemical-induced proximity (1)
- chemoattractant (1)
- chemoconvulsant (1)
- chemoembolization (1)
- chemogenomic set (1)
- chemokine (1)
- chemokine receptor 4 (1)
- chemokine receptors (1)
- chemokines: CYP2D6 model (1)
- chemoprevention (1)
- chemosensory cells (1)
- chemotaxis (1)
- chemotherapeutic drug resistance (1)
- chemotherapeutics (1)
- chemotherapeutics-treated (1)
- chemotherapy regimen (1)
- chemotherapy-resistance (1)
- chest injury (1)
- child abuse and neglect (1)
- child maltreatment (1)
- child psychiatry (1)
- childhood (1)
- childhood abuse (1)
- childhood cancer (1)
- children and adolescents (1)
- chimeric antigen receptor t-cell therapy (1)
- chimeric antigen receptors (1)
- chinese medicine (1)
- chloroplasts (1)
- cholangiocarcinoma (1)
- cholecystectomy (1)
- cholestasis (1)
- cholinesterase (1)
- chondrocyte (1)
- chondrocytes (1)
- chromatin immunoprecipitation (1)
- chromosomal breaks (1)
- chromosomal instability (1)
- chromosomal integration (1)
- chromosomal translocations (1)
- chromosome alignment (1)
- chromosome instability (1)
- chromosome segregation (1)
- chronic care (1)
- chronic colitis (1)
- chronic coronary artery disease (1)
- chronic granulomatous disease (1)
- chronic hepatitis C (1)
- chronic illness (1)
- chronic infection (1)
- chronic inflammation (1)
- chronic kidney disease (CKD) (1)
- chronic liver disease (1)
- chronic liver disease (CLD) (1)
- chronic metabolic acidosis (1)
- chronic myeloid leukemia (CML) (1)
- chronic total occlusion (1)
- chronic viral hepatitis (1)
- chronische Niereninsuffizienz (1)
- chronische metabolische Azidose (1)
- chronobiology (1)
- chronotype (1)
- cigarette smoke (1)
- cigarette strength (1)
- cigarettes (1)
- cigarillos (1)
- cilia (1)
- circadian variation (1)
- circular RNA (1)
- circulating miRNA (1)
- circulation (1)
- cisplatin sensitivity (1)
- citizen science (1)
- claims data (1)
- classical conditioning (1)
- classification of bone defects (1)
- clean room (1)
- clear or almost clear skin (1)
- clinical (1)
- clinical cases (1)
- clinical competency (1)
- clinical features (1)
- clinical history (1)
- clinical immunology (1)
- clinical management (1)
- clinical pathways (1)
- clinical practice (1)
- clinical relevance (1)
- clinical tool (1)
- clinical trials (1)
- clinically important restrictions and symptoms (1)
- clinico-biological indices (1)
- cloacae (1)
- cloacal malformation (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- clopidogrel (1)
- cluster of differentiation 4 (CD4) (1)
- cluster-randomized controlled trial (1)
- clusteranalysis (1)
- co-crystallization (1)
- co-infection (1)
- coaching (1)
- coauthor ship (1)
- cocaine (1)
- coffee (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive fluency (1)
- cognitive functions (1)
- cognitive models (1)
- cognitive states (1)
- cognitively stimulating leisure activities (1)
- cohlear implant (1)
- cohort study (1)
- cold induced pain (1)
- cold tolerance (1)
- colitis (1)
- collaborative feedback (1)
- collagen I (1)
- collagen VI (1)
- collagen adhesion (1)
- collagen degradation marker (1)
- collagen type I (1)
- collagen-based biomaterial (1)
- collagen-based matrix (1)
- collateral growth (1)
- collateral sprouting (1)
- collective dynamics (1)
- colloid (1)
- colon (1)
- colon cancer cells (1)
- colon carcinoma (1)
- colonization (1)
- colorectal cancer (CRC) (1)
- colorectal cancer liver metastases (CRLM) (1)
- column chromatography (1)
- combination (1)
- combination immunotherapy (1)
- combination therapies (1)
- combination treatment (1)
- combined immunodeficiency (1)
- common genetic variation (1)
- common neighbor (1)
- common variant (1)
- common variants (1)
- communication/social competencies (1)
- community violence exposure (1)
- comorbidities (1)
- comorbidity (1)
- compaction (1)
- comparative pathology (1)
- comparative study (1)
- competitive peptide (1)
- complement dependent cytotoxicity (1)
- complement; patients (1)
- complementary information (1)
- complementary psychosocial care (1)
- complex I deficiency (1)
- complex systems (1)
- complexity theory (1)
- complexome profiling (1)
- comprehensive care (1)
- computational biology (1)
- computational functional genomics (1)
- computational intelligence (1)
- computational modeling (1)
- computational models (1)
- computational neuroimaging (1)
- computational neuroscience (1)
- computational techniques (1)
- computer tomography (1)
- computer vision (1)
- computer-assisted (1)
- computer-assisted drug therapy (1)
- computerized programs (1)
- concentric (1)
- concordance (1)
- concurrent (1)
- concurrent TMS--fMRI (1)
- conditioning (1)
- conduit (1)
- cone-beam computed tomography (CBCT) (1)
- cone-beam computer tomography (1)
- confidence (1)
- confinement (1)
- congenic mice (1)
- congenital deafness (1)
- congruency (1)
- connectional fingerprint (1)
- connective tissue (1)
- connective tissue graft (1)
- conotoxin (1)
- consciousness (1)
- consensus (1)
- consolidation treatment (1)
- contact heat evoked potentials (CHEPS) (1)
- contact lens solution (1)
- continuing education (1)
- continuing medical education (1)
- continuous glucose monitoring (1)
- contralateral delay activity (1)
- controlled nuclear import (1)
- conventional laparoscopic (1)
- conventional/traditional transarterial chemoembolization (cTACE) (1)
- conversation skills (1)
- convolution neural network (1)
- convulsive seizures (1)
- cooling deactivation (1)
- cooling period (1)
- coordination (1)
- copeptin (1)
- coping (1)
- copy number polymorphism (1)
- cord clamping (1)
- corneas (1)
- corona virus (1)
- coronary (1)
- coronary artery bypass surgery (1)
- coronary calcium (1)
- coronary computed-tomography angiography (CCTA) (1)
- coronary disease (1)
- coronary plaques (1)
- coronavirus disease 2019 (1)
- corpus callosum (1)
- correction of incidence rate (1)
- correction of mortality rate (1)
- correlation (1)
- corrosion (1)
- cortex, gray matter (1)
- cortical folding (1)
- cortical layers and areas (1)
- cortical malformation (1)
- cortical network (1)
- cortical networks (1)
- cortical slices (1)
- cortical thickness (1)
- corticomuscular coherence (CMC) (1)
- cost-effective (1)
- cost-of-illness (1)
- costimulation (1)
- costs (1)
- coupling (1)
- courting behavior (1)
- cranberry (1)
- crestal bone loss (1)
- crime scene (1)
- crista junction (1)
- cristae (1)
- critical care unit (1)
- critical ill patients (1)
- critical periods (1)
- critical size defect (1)
- critically ill patients (1)
- cross-border (1)
- cross-communication (1)
- cross-modal (1)
- cross-modal plasticity (1)
- cross-sectional study (1)
- crowns (1)
- cryogenic electron microscopy (1)
- cryopreservation (1)
- cryotherapy (1)
- crystalloid (1)
- cultural and social transformation of sexuality (1)
- cumulative dose (1)
- curriculum (1)
- cutaneous T cell lymphoma (1)
- cuticular hydrocarbons (1)
- cyclic depsipeptide (1)
- cyclin D1 (1)
- cyclins (1)
- cyclooxygenase 1 (COX-1) (1)
- cyclooxygenase 2 (COX-2) (1)
- cyclophilin A (1)
- cyclophosphamide (1)
- cyclosporine (1)
- cys-loop receptor (1)
- cystatin C (1)
- cytarabin (1)
- cytarabine dose (1)
- cytokine (1)
- cytokine gene expression (1)
- cytokine release syndrome (1)
- cytokine, angiogenesis (1)
- cytoskeleton (1)
- cytotoxic immunotherapy (1)
- dNTP pools (1)
- dabigatran (1)
- daily activity protocols (1)
- damage associated molecular pattern (1)
- damage-associated molecular pattern (1)
- dapagliflozin (1)
- data modeling (1)
- data quality (1)
- data quality check (1)
- day clinic (1)
- deaf white cat (1)
- death (1)
- death receptor (1)
- debridement (1)
- decision aids (1)
- decision support systems (1)
- decision-making (1)
- declaration of tobacco ingredients (1)
- decomposition (1)
- deconvolution (1)
- decorin (1)
- decorrelation (1)
- dedifferentiation (1)
- deep mutational scanning (1)
- deep neural network (1)
- deep sedation (1)
- defect configuration (1)
- delay (1)
- delayed auditory feedback (1)
- delayed cholecystectomy (1)
- delayed wound healing (1)
- deletion 5q (1)
- delirium (1)
- delta-9-tetrahydrocannabinol (1)
- dendrite (1)
- dendritic cell–tumor cell fusion (1)
- dendritic inhibition (1)
- denervation (1)
- density equalizing mapping (1)
- dental abutment (1)
- dental assistant (1)
- dental emergency treatment (1)
- dental health professional (1)
- dentin adhesives (1)
- dentistry (1)
- dentoalveolar surgery (1)
- depolymerization (1)
- depressive symptoms (1)
- depressive symptoms clusters (1)
- deprivation (1)
- dermatology (1)
- dermatomes (1)
- desensitization (1)
- desmoplastic small round cell tumor (1)
- desmoplastic stroma (1)
- deswelling (1)
- deubiquitinating enzyme (1)
- deubiquitinating enzymes (1)
- devastated bladder outlet (1)
- device handling (1)
- dexamethasone (1)
- diabetes therapy (1)
- diabetic macular edema (1)
- diabetic nephropathy (1)
- diabetic neuropathy (1)
- diagnostic algorithm (1)
- diagnostic biomarkers (1)
- diagnostic method (1)
- diagnostic test (1)
- diagnostics (1)
- dialysis (1)
- diarrhoeal disease (1)
- diastolic function (1)
- diclofenac (1)
- diet (1)
- differentiated thyroid carcinoma (1)
- diffuse large B cell lymphoma (1)
- diffuse low-grade glioma (1)
- diffusion MRI (1)
- diffusion microstructure (1)
- diffusion tensor imaging (DTI) (1)
- digestive tract (1)
- digital age determination (1)
- digital didactics (1)
- digital pathology (1)
- digitale Didaktik (1)
- dihydroceramides (1)
- dimethylfumarate (1)
- dipeptide (1)
- diplopia (1)
- direct antiviral (1)
- direct antiviral agents (1)
- direct-acting antivirals (DAAs) (1)
- directed disulfide bond formation (1)
- directed forgetting (1)
- directly acting antiviral agents (1)
- disasters (1)
- discoidin domain-containing receptor (1)
- discomfort/pain (1)
- discontinuous dose dependency (1)
- disease modelling (1)
- disease progression (1)
- disease-free survival (1)
- disease-modifying antirheumatic drugs (1)
- disease-modifying therapy (1)
- dislocation (1)
- disposable insulin pens (1)
- disruptive behaviour disorder (1)
- dissemination (1)
- dissimilatory sulfite reductase (1)
- distal pronephric outlet obstruction (1)
- distance learning (1)
- distraction (1)
- distributed computation (1)
- diuretics (1)
- diurnal (1)
- docetaxel (1)
- docking studies (1)
- dog study (1)
- donor deferral (1)
- donor recruitment (1)
- donor retention (1)
- dopamine (1)
- doppler (1)
- dorsal auditory stream (1)
- dose response curve (1)
- dosimetry (1)
- dosing accuracy (1)
- double inversion recovery (DIR) (1)
- double orifice mitral valve (1)
- doublecortin (1)
- doxycycline (1)
- drilling tool design (1)
- drug delivery (1)
- drug hepatotoxicity (1)
- drug interaction (1)
- drug metabolism and distribution (1)
- drug resistance and invasiveness (1)
- drug screening (1)
- drug targets (1)
- drug therapy (1)
- drug-coated balloon (1)
- drug-eluting balloon (1)
- drug-eluting beads TACE (DEB-TACE) (1)
- drug-induced liver injury (DILI) (1)
- druggable genome (1)
- drugs (1)
- drug‐resistant epilepsy (1)
- dsr genes (1)
- dual antiplatelet therapy (1)
- dual bronchodilators (1)
- dynamic 18F-FDG PET/CT (1)
- dynamic connectivity (1)
- dynamic stimuli (1)
- dysbiosis (1)
- dysferlin (1)
- dysferlinopathy (1)
- dyssynchrony analysis (1)
- e-Health (1)
- e-scooter (1)
- eNOS (1)
- eNPP2 (1)
- ePTFE membrane (1)
- early cholecystectomy (1)
- early continence (1)
- early epilepsy (1)
- early infection (1)
- early loss (1)
- early myocardial damage (EMD) (1)
- early recognition (1)
- early tumor stages (1)
- eating disorders (1)
- eccentric (1)
- economic burden (1)
- economy (1)
- ectopic pregnancy (1)
- edema (1)
- editorials (1)
- edoxaban (1)
- educational cases (1)
- educational measurement (1)
- educational settings (1)
- educational technology (1)
- educational theory (1)
- effect mechanism (1)
- effective lens position (1)
- effectiveness (1)
- eight disorders (1)
- ejection fraction (EF) (1)
- electric and acustic stymulation (1)
- electric scooter (1)
- electrical stimulation (1)
- electroconvulsive therapy (1)
- electroencephalography (EEG), EEG reference choices, event-related potentials (ERP), independent component analysis (ICA), pain research, contact heat evoked potentials (CHEPS) (1)
- electromagnetic navigation bronchoscopy (EMN, ENB) (1)
- electrophiles (1)
- elite athlete (1)
- eltrombopag (1)
- embodiment (1)
- embolization (1)
- emergence (1)
- emergency care (1)
- emergent self-organizing maps (1)
- emotion (1)
- emotional climate (1)
- emotional information processing (1)
- empagliflozin (1)
- empowerment (1)
- emulsion diffusion (1)
- encoding strategies (1)
- end of life care (1)
- endocarditis (1)
- endogenous clock (1)
- endometrial cancer (1)
- endometriosis (1)
- endophytes (1)
- endoscopic retrograde cholangiopancreatography (1)
- endoscopy (1)
- endothelial activation (1)
- endothelial barrier (1)
- endothelial function (1)
- endothelial nitric-oxide synthase (1)
- endothelial receptor expression (1)
- endothelial to mesenchymal transition (1)
- endothelin (1)
- endothelin receptor type A antagonist (1)
- endothelium (1)
- endotoxemia (1)
- endotoxins (1)
- enforced viral replication (1)
- english (1)
- enterovirus (1)
- entomological evidence (1)
- envelope technique (1)
- environment (1)
- eosinophil cationic protein (1)
- eosinophilic cholangitis (1)
- eosinophils (1)
- epidemics (1)
- epidermal growth factor (1)
- epidermal growth factor receptor (1)
- epidermis (1)
- epididymitis (1)
- epigenetic memory (1)
- epigenome (1)
- epigenomics (1)
- epileptic encephalopathies (1)
- epileptic encephalopathy (1)
- epiregulin (1)
- epithelial cells (1)
- epithelial mesenchymal transition (1)
- epithelial‐mesenchymal transition (1)
- epitope mapping (1)
- erectile dysfunction (1)
- ergometry (1)
- ergonomics (1)
- erosions (1)
- erythropoietin (1)
- erythropoietin (EPO) (1)
- escape mutations (1)
- esterification (1)
- ethical trade-off (1)
- ethyl pyruvate (1)
- eutheria (1)
- euthymic (1)
- evaluation practice (1)
- event logs (1)
- event-based (1)
- event-related potential (1)
- event-related potentials (ERP) (1)
- evoked response (1)
- evolution (1)
- ex vivo expansion (1)
- ex vivo model (1)
- ex vivo stimulation (1)
- ex-Gaussian analysis (1)
- examination success (1)
- excess fluid volume (1)
- excitability (1)
- executive control (1)
- executive function (1)
- exercise on prescription (1)
- exercise physiology (1)
- exercise testing (1)
- exercise training (1)
- exome sequencing (1)
- experimental human pain models (1)
- expert review (1)
- explainable AI (1)
- exponential model (1)
- exposure (1)
- expressed emotion (1)
- expression studies (1)
- extensive surgery (1)
- extensively drug-resistant (1)
- external fixation (1)
- external joint moments (1)
- extracellular chromatin (1)
- extracellular vesicles (1)
- extracting solvents (1)
- extraction socket healing (1)
- extremity (1)
- eye movement (1)
- eye tracking (1)
- eye-tracking (1)
- face (1)
- face inversion effect (1)
- face-name association task (1)
- facial EMG (1)
- facial emotion recognition (1)
- facial expressions of emotion (1)
- facial muscle activity (1)
- facial nerve functional outcome (1)
- facial prosthesis (1)
- factor IX (1)
- factor VIII (1)
- factor VIII (FVIII) (1)
- falls (1)
- false memory (1)
- familial colorectal cancer (1)
- familial infantile epilepsy (1)
- familiengerechte Hochschule (1)
- family medicine (1)
- family-friendly universities (1)
- fat (1)
- fatty acid elongase (Elovl1/4/5) (1)
- fatty acids (1)
- fear conditioning (1)
- fear extinction (1)
- fear generalization (1)
- fear learning (1)
- feeder cells (1)
- feeding (1)
- female health (1)
- female subjects (1)
- femoropopliteal segment (1)
- ferret (1)
- ferric carboxymaltose (1)
- fetal weight estimation (1)
- fiber orientations (1)
- fibre tracking (1)
- fibrin (1)
- fibrinolysis (1)
- fibroblast (1)
- fibrocytes (1)
- fibrogenesis (1)
- fibromodulin (1)
- fibronectin (1)
- fibrosarcoma (1)
- fibrotest (1)
- fidaxomicin (1)
- finger tapping (1)
- fingolimod (1)
- first-line chemotherapy (1)
- fitness (1)
- fixation (1)
- fixed partial dentures (1)
- fizička aktivnost; (1)
- flavivirus entry factor (1)
- fluid (1)
- fluid shear stress (1)
- fluocinolone acetonide (1)
- fluorescent dye (1)
- fluorine (1)
- focal adhesion kinase (1)
- focal cortical dysplasia (FCD) (1)
- focal seizures (1)
- focal therapy (1)
- follow-up (1)
- forensics (1)
- formalin-fixed and paraffin-embedded tissue (FFPE) (1)
- formalin-fixed paraffin-embedded (FFPE) samples (1)
- fourth (1)
- fractional anisotropy (1)
- free gingival graft (1)
- free leptin index (FLI) (1)
- freeze avoidance (1)
- fresh frozen plasma (1)
- frontal cortex (1)
- frontotemporal lobar degeneration (1)
- full-contour crown restorations (1)
- full-contour zirconia (1)
- fully human (1)
- fumonisin B1 (1)
- function, sorting (1)
- functional MRI (1)
- functional imaging (1)
- functional magnetic resonance imaging (fMRI) (1)
- fundoplication (1)
- fungal pathogens (1)
- fungi (1)
- fungus (1)
- funktionelle Bildgebung (1)
- furcation involvement (1)
- further education (1)
- fusion (1)
- gRNA library (1)
- gadobutrol (1)
- gadolinium (1)
- gadolinium enhancing lesion (1)
- gadolinium‐based contrast agent (1)
- galactomannan (1)
- gallbladder cancer (1)
- gallbladder cancer xenografts (1)
- gallstone disease (1)
- galunisertib monohydrate (LY2157299) (1)
- gap junction protein alpha 4-genotype (1)
- gas chromatography-mass spectrometry (1)
- gastric (1)
- gastric surgery (1)
- gastro-oesophageal junction cancer (1)
- gastroesophageal reflux (1)
- gastrointestinal tract (1)
- gel spacer injection (1)
- gender difference (1)
- gender dysphoria (1)
- gender equality (1)
- gender equality plan (1)
- gender studies (1)
- gender-affirming hormone therapy (1)
- gene delivery (1)
- gene expression analysis (1)
- gene expression profiling (1)
- gene expression profiling (GEP) (1)
- gene signature (1)
- gene vectors (1)
- general anaesthesia (1)
- general practitioner (1)
- generic preparedness (1)
- genes (1)
- genetic diversity (1)
- genetic generalized epilepsy (1)
- genetic markers (1)
- genetic phenotypes (1)
- genetic polymorphisms (1)
- genetic predisposition (1)
- genetic rearrangements (1)
- genetics and genomics (1)
- gene×environment interactions (1)
- genome (1)
- genome editing (1)
- genome-wide (1)
- genome-wide association study (1)
- genomic classifiers (1)
- genotype (1)
- genotype determination (1)
- geriatric medicine (1)
- germ cell tumors (1)
- germinal center (1)
- gland extracts (1)
- glecaprevir (1)
- glial activation (1)
- glial fibrillary acidic protein (1)
- glioblastoma (GBM) (1)
- glioblastoma stem-like cells (1)
- glioma-associated oncogene homolog (1)
- gliomas (1)
- gliomatosis cerebri growth pattern (1)
- global diversity (1)
- global mapping (1)
- global warming (1)
- glucocorticoid (1)
- glucocorticoids (1)
- glucosamine (1)
- glucose (1)
- glutamate metabolism (1)
- glutamine (1)
- glycation (1)
- glycolysis (1)
- glycosaminoglycan (1)
- gold nanoparticles (1)
- good manufacturing practice (1)
- gossypol (1)
- governance (1)
- graft (1)
- graft perfusion (1)
- graft rejection (1)
- graft-versus host (1)
- graft-versus-host disease (1)
- graft-versus-tumor effect (1)
- gram-negative bacteria (1)
- granulocyte (1)
- granulocytecolony stimulating factor (1)
- granulocytemacrophage colony-stimulating factor (1)
- granuloma (1)
- granulomas (1)
- granulomatous inflammation (1)
- gray matter (1)
- gray matter changes (1)
- gray‐white matter blurring (1)
- green fluorescent protein (1)
- green tea extract (1)
- grey matter volume (1)
- grinding (1)
- grounded theory (1)
- growth hormone (1)
- guanidine alkaloid (1)
- guessing likelihood (1)
- guidance (1)
- guinea pig (1)
- gut microbiota (1)
- gyrification (1)
- h-index (1)
- hMOF/KAT8 (1)
- habituation (1)
- haematologic malignancies (1)
- haemophilia (1)
- haemophilia A (1)
- haemophilic arthropathy (1)
- haemostasis (1)
- hair cell (1)
- hand area (1)
- hanging donors (1)
- haplo-identical (1)
- haploidentical (1)
- harassment (1)
- harmine (1)
- head and neck neoplasms (1)
- head and neck squamous cell carcinoma (1)
- head to head (1)
- head zones (1)
- head-and-neck cancer (1)
- head-to-head (1)
- headache (1)
- health apps (1)
- health care (1)
- health care personnel (1)
- health economics (1)
- health insurance data (1)
- health literacy (1)
- health related quality of life (1)
- health services accessibility (1)
- health services research (1)
- healthcare (1)
- healthcare personnel (1)
- healthcare professional (1)
- healthcare systems (1)
- healthcare worker (1)
- healthcare workers (1)
- healthy subjects (1)
- health‐related quality of life (1)
- hearing loss (1)
- hearing nerve (1)
- heart (1)
- heart rate variability (1)
- heat (1)
- heat stress (1)
- hedgehog (1)
- hedgehog signaling pathway (1)
- helminths (1)
- hemadsorption (1)
- hemagglutination (1)
- hematoma (1)
- hematopoietic cell transplantation (1)
- hematopoietic cells (1)
- hematopoietic stem cell mobilization (1)
- hematopoietic stress (1)
- hemiplegic migraine (1)
- hemispherotomy (1)
- hemodynamic (1)
- hemodynamic instability (1)
- hemophilia A (1)
- hemorrhage (1)
- hemorrhagic transformation (1)
- hepatic fibrosis (1)
- hepatic osteodystrophy (1)
- hepatic phenotype (1)
- hepatic steatosis (1)
- hepatic tumor (1)
- hepatitis B virus (1)
- hepatitis E (1)
- hepatitis E virus (1)
- hepatitis c (1)
- hepatoblastoma (1)
- hepatocellular carcinoma (HCC) (1)
- hepatocyte transplantation (1)
- hepatocytes (1)
- hepatotoxicity (1)
- herb induced liver injury (HILI) (1)
- herbal drug (1)
- herbs (1)
- hereditary angioedema, (1)
- hereditary tumor syndromes (1)
- hernia to the cord (1)
- herpes simplex virus (1)
- heterogeneity of plasticity effects (1)
- hexosamine biosynthetic pathway (1)
- hiPSC (1)
- hierarchy (1)
- high molecular weight plasticizer (1)
- high surgical risk (1)
- high throughput (1)
- high-dimensional data sets (1)
- high-dose chemotherapy (1)
- high-dose-rate interstitial brachytherapy (1)
- high-energy photon and proton radiation (1)
- high-intensity focused ultrasound ablation (1)
- high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (1)
- high-pitch (1)
- high-throughput nucleotide sequencing (1)
- high-throughput sequencing (1)
- higher education (1)
- higher education pedagogy (1)
- highly parallel recordings (1)
- high‐mobility group box‐1 (HMGB1) (1)
- hip joint (1)
- hippocampal neuronal cell line (1)
- hippocampal sclerosis (1)
- hippocampal volume (1)
- histamine (1)
- histological technic (1)
- histomorphometry (1)
- histone deacetylase (1)
- histone deacetylase 5 (1)
- histone deacetylases (HDACs) (1)
- histone modification (1)
- histoplasmosis (1)
- history (1)
- history of medicine (1)
- history taking (1)
- hiv (1)
- home care services (1)
- home visit (1)
- homeostatic synaptic scaling (1)
- homing (1)
- homoarginine (1)
- homologna transplantacija (1)
- hormonal therapy (1)
- hormone (1)
- hormones (1)
- hospital (1)
- hospital exemption (1)
- hospitalization (1)
- host cell interaction (1)
- host cell response (1)
- host immune response (1)
- host response (1)
- host-directed therapies (1)
- host-pathogen interaction (1)
- host-targeting antivirals (1)
- hostpathogen interaction (1)
- hotspot loci (1)
- house dust mite allergy (1)
- household chaos (1)
- huCAR19 (1)
- human Natural Killer cell (1)
- human antigen R (HuR) (1)
- human brain (1)
- human decellularized dermis (1)
- human erythroid leukemia (HEL) (1)
- human experimental pain (1)
- human genomics (1)
- human gingival fibroblasts (1)
- human immunodeficiency virus (1)
- human intracranial recordings (1)
- human knockout model (1)
- human lymph node (1)
- human natural killer cell (1)
- human papilloma virus (1)
- human renal proximal tubular epithelial cells (1)
- human resources (1)
- human sera (1)
- human skin graft (1)
- humanized mice (1)
- humanized mouse (1)
- humanized mouse model (1)
- humans (1)
- humectant agents (1)
- humoral factors (1)
- hybrid (1)
- hydrocephalus (1)
- hydroxyapatite crystals (1)
- hydroxyurea (1)
- hygienic hand disinfection (1)
- hygienische Händedesinfektion (1)
- hymenoptera (1)
- hyperalgesia (1)
- hyperammonemia (1)
- hyperarousal (1)
- hyperbaric oxygen treatment (1)
- hyperlipidemia (1)
- hypertension (1)
- hypertension and anti-hypertensive treatment (1)
- hypertension, pulmonary (1)
- hypertonic (1)
- hypoglycaemia (1)
- hyponatremia (1)
- hypoparathyroidism (1)
- hypophosphataemia (1)
- hypothalamus (1)
- hypothermia (1)
- hypoxia-induced cell death (1)
- hypoxia-inducible factor (1)
- hysteresis (1)
- i-AAA protease (1)
- iCBT (1)
- iCLIP (1)
- iDrug induced liver injury (1)
- idiopathic dystonia (1)
- idiopathic pulmonary fibrosis (1)
- idiosyncratic DILI (1)
- idiosyncratic drug-induced liver injury (1)
- ifenprodil (1)
- ignition (1)
- illness experiences (1)
- image analysis (1)
- image distortion (1)
- image-based risk modelling (1)
- imiquimod (1)
- imitation (1)
- immune (1)
- immune checkpoint inhibitors (1)
- immune deficiency (1)
- immune dysregulation (1)
- immune function (1)
- immune landscape (1)
- immune microenvironment (1)
- immune modulation (1)
- immune responses (1)
- immune surveillance of cancer (1)
- immune therapy (1)
- immune tolerance (1)
- immune-checkpoint inhibition (1)
- immune-mediated inflammatory diseases (1)
- immune-modulating therapy (1)
- immunization (1)
- immunocompromised patient (1)
- immunoglobulin superfamily (1)
- immunologic (1)
- immunological research (1)
- immunology and infectious diseases (1)
- immunomagnetic (1)
- immunoprecipitation (1)
- immunostaining (1)
- immunosuppressants (1)
- immunosuppression (1)
- immunosuppressive agent (1)
- immunosuppressive drug (1)
- impact factor (1)
- implant (1)
- implant movement (1)
- implant stability (1)
- implant survival (1)
- implanto-prosthetic therapy (1)
- imported malaria (1)
- improvement in quality of life (1)
- in silico simulation (1)
- in situ gene correction (1)
- in situ hybridization (1)
- in situ vaccine (1)
- in vivo micro‐CT (1)
- in vivo model of critical size defects (1)
- in-cabin exposure (1)
- incisional hernia (1)
- indacaterol/glycopyrronium (1)
- independent component analysis (ICA) (1)
- indication (1)
- individual moulds (1)
- individualized solutions (1)
- individualized therapy (1)
- indomethacin (1)
- indoor air pollution (1)
- inducible gene expression (1)
- inducible nitric oxide synthase (1)
- induction chemotherapy (1)
- infant (1)
- infants (1)
- infection eradication (1)
- infection model (1)
- infections: pneumonia, TB, viral (1)
- infectious disease (1)
- infectious diseases (1)
- infectivity (1)
- inflammatory arthritis (1)
- inflammatory cytokines (1)
- inflammatory markers (1)
- influenza (1)
- influenza pandemic (1)
- influenza vaccination (1)
- influenza vaccine (1)
- infomax (1)
- information decomposition (1)
- information needs (1)
- information storage (1)
- information transfer (1)
- inhalation flow profiles (1)
- inhaled steroids (1)
- inhaler (1)
- inheritance (1)
- inhibition (1)
- inhibition of DNA-binding (1)
- inhibitor of apoptosis protein family (1)
- inhibitors (1)
- injury (1)
- innate and adaptive immune response (1)
- innate immune system (1)
- innate lymphoid cells (1)
- inner ear therapy (1)
- inpatient hospital admissions (1)
- insect herbivory (1)
- insecticide (1)
- insertable cardiac monitor (1)
- insertion (1)
- insomnia (1)
- instructional interventions (1)
- insulitis (1)
- integrate and fire (1)
- integrated stress response (1)
- intensive care (1)
- intensive care unit (1)
- inter-assay precision (1)
- interactome (1)
- interaural time difference (1)
- interference (1)
- interferon regulatory factor 9 (IRF9) (1)
- interferon-free (1)
- interferon-free antiviral treatment (1)
- interferon-γ (1)
- interferons (1)
- interleukin-1 (1)
- interleukin-10 (1)
- interleukin-1β (1)
- interleukin-23 receptor (1)
- interleukin-6 (1)
- internal ribosomal entry site (IRES) (1)
- internal time (1)
- international (1)
- internet (1)
- internet- and mobile-based intervention (1)
- internet-based cognitive behavioral therapy (1)
- internet-based treatment (1)
- interneurons (1)
- interscalene brachial plexus block (1)
- interstitial brachytherapy (1)
- interstitial lung disease (1)
- intervention (1)
- intervention study (1)
- interventional radiology (1)
- intervertebral disc (1)
- intervertebral disc (IVD) (1)
- intervertebral disc degeneration (1)
- intestinal barrier (1)
- intestinal graft-versushost disease (1)
- intestinal obstruction (1)
- intoxication (1)
- intra-arterial chemotherapy (1)
- intraarterial therapy (1)
- intracellular trafficking (1)
- intracerebral haemorrhage (1)
- intracerebral hemorrhage (1)
- intracranial hemorrhage (1)
- intraperitoneal therapy (1)
- intratumoral (1)
- intraventricular chemotherapy (1)
- intravital microscopy (1)
- intrinsic DILI (1)
- intrinsic apoptosis (1)
- intrinsic drug resistance (1)
- intronic ORF (1)
- invasive growth (1)
- invasive mold infection (1)
- inverse dynamics (1)
- involuntary hospitalization (1)
- in vivo (1)
- ion channel (1)
- ionomycin (1)
- ionotropic glutamate receptors (1)
- irbesartan (1)
- irinotecan-loaded drug-eluting beads TACE (DEBIRI-TACE) (1)
- iron chelation (1)
- iron chelator (1)
- iron chelators (1)
- iron deficiency (1)
- iron homeostasis (1)
- iron metabolism (1)
- iron overload versus deprivation (1)
- iron supplements (1)
- irritable bowel syndrome (1)
- ischaemia (1)
- ischemia (1)
- ischemic stroke (1)
- ischemic type biliary lesions (1)
- isocaloric ketogenic diet (1)
- isogenic (1)
- isomeric antagonists (1)
- isovaleric acidaemia (1)
- isradipine (1)
- isušenje (1)
- itraconazole (1)
- ixekizumab (1)
- joint bleeding (1)
- joint contact forces (1)
- joint loading (1)
- joint moments (1)
- junctional adhesion molecule (1)
- juvenile brain lesion (1)
- juvenile myoclonic epilepsy (1)
- kallikrein inhibitor (1)
- kavalactones (1)
- keratinized mucosa (1)
- keratinocytes (1)
- keratoplasty (1)
- ketamine (1)
- ketogenic (1)
- ketogenic diet (1)
- ketone body (1)
- kidney disease (1)
- kidney formation (1)
- kidney function (1)
- kinesin (1)
- kinetic fingerprint (1)
- klinische Kompetenz (1)
- klinische Studie (1)
- knee joint (1)
- knockout mice (1)
- knockout mouse (1)
- kommunikative/soziale Kompetenzen (1)
- konduit (1)
- koroner arter baypas cerrahisi (1)
- kutane Larva migrans (1)
- kynureninase (1)
- kynurenine (1)
- kyphosis (1)
- l-DOPA (1)
- laceration (1)
- lacosamide (1)
- lactate (1)
- lactate dehydrogenase (1)
- laminin (1)
- laminins (1)
- lamotrigine (1)
- language (1)
- laser (1)
- laser based cell manipulation (1)
- laser microdissection (1)
- laser-capture microdissection (1)
- late lumen loss (1)
- late-life depression (1)
- latent class analysis (1)
- latent tuberculosis infection (1)
- layer 1 (1)
- layer-specificity (1)
- learning (1)
- learning curve (1)
- learning strategies (1)
- left ventricular function (1)
- left ventricular non-compaction (1)
- left ventricular trabeculation (1)
- leg alignment (1)
- legal gender reassignment (1)
- lenalidomide (1)
- length of study (1)
- lentiviral vector (1)
- leptin (1)
- leptin, leptin receptor (sOB-R) (1)
- leptomeningeal disease (1)
- leptomeningeal metastases (1)
- lethal toxin (1)
- leukapheresis (1)
- leukemia initiating cell (1)
- leukemia; solid tumors (1)
- leukocytosis (1)
- leukodystrophy (1)
- leukotriene (1)
- life cycle (1)
- life span (1)
- lifelong learning (1)
- lifespan (1)
- ligelizumab (1)
- light microscopy (1)
- light transmission aggregometry (1)
- limb girdle muscular dystrophy type 2B (LGMD2B) (1)
- liminality (1)
- linoleic acid metabolites (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipid raft (1)
- lipid signaling (1)
- lipid signalling (1)
- lipid-protein interaction (1)
- lipidomic analysis (1)
- lipidomics (1)
- lipids (1)
- lipids inflammatory pain (1)
- lipiodol (1)
- lipopolyplex (1)
- lipopolysaccharide (1)
- liposomes (1)
- liquid PRF (1)
- liquid-PRF (1)
- live cell imaging (1)
- liver abscess (1)
- liver adaption (1)
- liver cancer (1)
- liver cell lines (1)
- liver damage (1)
- liver diseases (1)
- liver immunology (1)
- liver metabolism (1)
- liver transplantation center (1)
- livermetastases of colorectal cancer (1)
- living will (1)
- local anesthetic (1)
- local field potential (1)
- local inflammation (1)
- local radiotherapy (1)
- lockdown (1)
- locomotor rhythm (1)
- locoregional chemotherapy (1)
- long essay questions (1)
- long essey questions (1)
- long non-coding RNA (1)
- long noncoding RNAs (1)
- long reads (1)
- long-acting muscarinic antagonist (1)
- long-acting β2-agonists (1)
- long-term depression (1)
- long-term distress (1)
- long-term follow-up (1)
- long-term infection (1)
- long-term infusion (1)
- long-term outcome (1)
- long-term potentiation (1)
- longitudinal follow-up after epilepsy surgery (1)
- longitudinal relaxation time T1 (1)
- longitudinally extensive transverse myelitis (1)
- loss (1)
- loss of signal (1)
- low birth weight infant (1)
- low doses (1)
- low speed centrifugation concept (1)
- low-back pain (1)
- low-cost medication (1)
- low-density lipoprotein cholesterol (1)
- low-dose imaging (1)
- low-dose radiation therapy (1)
- low-risk (1)
- lower extremity arterial disease (1)
- lower urinary tract obstruction (1)
- lumican (1)
- lung (1)
- lung disease (1)
- lung disease phenotype (1)
- lung remodeling (1)
- lung transplantation (1)
- luteolin (1)
- lymph nodes (1)
- lymphangiogenesis (1)
- lymphocyte (1)
- lymphocytes (1)
- lymphoma pathogenesis (1)
- lysosomes (1)
- l‐arginine:glycine amidinotransferase (1)
- mGluR3 (1)
- mGluR5 (1)
- mPGES-1 (1)
- mRNA (1)
- mRNA active cancer immunotherapy (1)
- mRNA and protein expression (1)
- mRNA decay (1)
- mRNA export (1)
- mRNA stability (1)
- mRNA vaccine (1)
- mTOR inhibition (1)
- mTOR inhibitor (1)
- mTOR inhibitors (1)
- mTORC (1)
- macula (1)
- macular hole (1)
- magentoencephalography (MEG) (1)
- magnetic field gradient (1)
- magnetic resonance imaging of the brain (1)
- magnetoencephalography (MEG) (1)
- maintenance therapy (1)
- major adverse cardiac events (1)
- major adverse cardiovascular events (1)
- major depression (1)
- major depression (MD) (1)
- major depressive disorder (1)
- major depressive disorder (MDD) (1)
- malaria elimination (1)
- malignancy (1)
- malignant glioma (1)
- mammals (1)
- mammary cancer (1)
- mammary carcinoma (1)
- mammary carcinomas (1)
- mandatory reporting system (1)
- mantle cell lymphoma (1)
- marathon (1)
- maraton (1)
- markovianity (1)
- maspin (1)
- mass spectrometry-based proteomics (1)
- massive parallel sequencing (1)
- massive weight loss (1)
- maternal care (1)
- maternal tobacco smoke (1)
- matrikine (1)
- matrix metalloproteinase (1)
- matrix metalloproteinases (1)
- maturation (1)
- mature T-cell lymphoma (1)
- mean diffusivity (1)
- measure development/validation (1)
- mechanical stimuli (1)
- mechanism of action (1)
- mechanistic target of rapamycin (mTOR) (1)
- mechanobactericidal surfaces (1)
- medial prefrontal cortex (1)
- medial thigh lift (1)
- medical and health research (1)
- medical error (1)
- medical history (1)
- medical illustration (1)
- medical informatics initiative (1)
- medical psychologoy (1)
- medical school (1)
- medical studies admission (1)
- medical teacher (1)
- medical teaching (1)
- medication (1)
- medication reconciliation (1)
- medication review (1)
- medications (1)
- medulloblastoma (1)
- medulloblastoma resection (1)
- memantine (1)
- membrane (1)
- membrane potential (1)
- membrane protein (1)
- membrane protein complex (1)
- membrane repair (1)
- membrane structure (1)
- memebrane (1)
- memory and learning tests (1)
- memory performance (1)
- mental health (1)
- mental health services (1)
- menthol (1)
- mentoring (1)
- men’s (1)
- merkel cell carcinoma (1)
- mesenchymal (1)
- mesenchymal stem cell (1)
- mesenchymal stromal cell (1)
- meta-analysis (1)
- metabolic cancer therapy (1)
- metabolic reprogramming (1)
- metabolic syndromes (1)
- metabolites (1)
- metalloprotease (1)
- metamorphosis (1)
- metaplasticity (1)
- metastability (1)
- metastasis-directed radiotherapy (1)
- metastates (1)
- metastatic cancer (1)
- metastatic colorectal cancer (1)
- metastatic melanoma stage IV (1)
- metastatic urethral cancer (1)
- meter (1)
- methotrexate (1)
- methylation profiling (1)
- methylglyoxal (1)
- methyltransferases (1)
- miR (1)
- miR-122 (1)
- miR-143-3p (1)
- miR-181 (1)
- miR-21 (1)
- miR-375 (1)
- miRNA let-7e (1)
- miRNA-17–92 (1)
- micelles (1)
- micro CT (1)
- microRNAs (1)
- microcirculation (1)
- microdeletions (1)
- microkeratome (1)
- microlesions (1)
- microplasmin (1)
- microsaccades (1)
- microsatellite instability (1)
- microsomal ethanol-oxidizing system (MEOS) (1)
- microsurgical treatment (1)
- microtubular cytoskeleton (1)
- microtubule disruptors (1)
- microtubule dynamics (1)
- microtubule-targeting agents (1)
- microwave breast imaging (1)
- midkine (1)
- migrants (1)
- migration and invasion (1)
- mindfulness (1)
- mini gastric bypass (1)
- minimal clinically important difference (1)
- minimally invasive cardiac surgery (1)
- mino acid metabolism (first pass) (1)
- mir-148a (1)
- mismatch repair (1)
- mitochondrial bioenergetics and glycolysis (1)
- mitochondrial dynamics (1)
- mitochondrial dysfunction (1)
- mitogen-activated protein kinase (1)
- mitogenic effects (1)
- mitomycin C (1)
- mitostatin (1)
- mitotic arrest (1)
- mitotic kinases (1)
- mixed micelles (1)
- mobile air quality study (1)
- mobile phone apps (1)
- mobile tongue cancer (1)
- mobilization (1)
- model curriculum (1)
- model psychosis (1)
- moisturing cream (1)
- molecular characteristics (1)
- molecular diagnosis (1)
- molecular diagnostics (1)
- molecular dynamics (1)
- molecular dynamics simulation (1)
- molecular identification (1)
- molecular marker (1)
- molecular pathology (1)
- molecular targeted drugs (1)
- molecular targeting (1)
- molecular therapy (1)
- molecular tumor board (1)
- molecular typing (1)
- momilactone A (1)
- momilactone B (1)
- monitoring (1)
- monkey (1)
- monkeys (1)
- monoamine oxidase A (1)
- monoclonal antibody (1)
- monocrotaline (1)
- monocyte chemotactic protein 1 (MCP-1) (1)
- monogenic disorders (1)
- mononuclear cell (1)
- montelukast (1)
- morbidity (1)
- morphological filtering (1)
- morphometry (1)
- motifs (1)
- motion analysis (1)
- motion capture (1)
- motor control (1)
- motor cortex (1)
- motor neuron disease (1)
- motor task (1)
- motor-evoked potential (1)
- mountain (1)
- mouse models (1)
- movement disorders (1)
- movement pattern (1)
- movement profile (1)
- mpMRI (1)
- mtor (1)
- mucormycete (1)
- mucormycetes (1)
- mucosal inflammation (1)
- mucositis (1)
- multi-drug resistance (1)
- multidisciplinary pain treatment (1)
- multidrug-resistant Gram-negative bacteria (MRGN) (1)
- multifocal (1)
- multimedia (1)
- multimodal complex treatment (1)
- multimorbidity [MeSH] (1)
- multiple choice question (1)
- multiple choice questions (1)
- multiple chronic conditions (1)
- multiple myeloma (1)
- multiple trauma (1)
- multiplex immunofluorescence (1)
- multiresistente Gram-negativen Stäbchenbakterien (MRGN) (1)
- multisensory (1)
- multisensory integration (1)
- multisite cooperation (1)
- multiunit activity (1)
- murine model (1)
- muscle (1)
- muscle disease (1)
- muscular dystrophies (1)
- muscular dystrophy (1)
- musculoskeletal modeling (1)
- musculoskeletal pain (1)
- musician (1)
- mutated neoantigens (1)
- mutational antigenic profiling (1)
- mutations (1)
- mutually exclusive mutations (1)
- mycophenolate mofetil [MMF] (1)
- myeloid cells (1)
- myeloperoxidase (1)
- myocardial infarction (1)
- myocardial injury (1)
- myocardial perfusion (1)
- myocarditis (1)
- myocardium (1)
- myocyte enhancer factor 2 (1)
- myoferlin (1)
- myogenic tone (1)
- myogenic vasoconstriction (1)
- myositis (1)
- myotonia congenita (1)
- nadomjesci za kost (1)
- nadp (1)
- naked haplo (1)
- nanobodies (1)
- nanoparticle (1)
- nanostructures (1)
- narrative content analysis (1)
- narrative economics (1)
- narrative medicine (1)
- natriuretic peptide (1)
- natural compounds (1)
- natural cytotoxicity (1)
- natural killer T cells (1)
- natural killer cell cultivation (1)
- natural killer cell cytotoxicity (1)
- natural killer cell expansion (1)
- natural killer cell therapy (1)
- natural sciences (1)
- naturalistic sample (1)
- necrosis (1)
- needle displacement (1)
- needs assessment (1)
- negative symptoms (1)
- neglect (1)
- negligencia (1)
- nematophin (1)
- neoadjuvant treatment (1)
- neocortex development (1)
- neocortical circuits (1)
- neoepitopes (1)
- neonatal intensive care unit (1)
- neonatal septic shock (1)
- neonates (1)
- neonatology (1)
- neosexual revolution (1)
- neosexualities (1)
- neovascularization, physiologic (1)
- nerve growth factor (NGF) (1)
- nerve injury (1)
- nerve-sparing (1)
- network (1)
- network neuroscience (1)
- network topology (1)
- networks (1)
- neural adaptation (1)
- neural computation (1)
- neural development (1)
- neural dynamics (1)
- neural systems (1)
- neurale Stammzellen (1)
- neuraminidase inhibitor (1)
- neuro-ophthalmological examination (1)
- neurobiology (1)
- neuroblastoma regression (1)
- neurocognition (1)
- neurodegenerative diseases (1)
- neurodevelopmental (1)
- neurodevelopmental disorders (1)
- neuroendocrine (1)
- neurofibrillary pathology (1)
- neuroinflammation (1)
- neuroinformatics (1)
- neurological diseases (1)
- neurological emergencies (1)
- neurological impairment (1)
- neurological outcome (1)
- neuronal avalanches (1)
- neuronal maturation (1)
- neuronale Netzwerke (1)
- neuronale Vorläuferzellen (1)
- neurons (1)
- neurooncology (1)
- neuropathological diagnosis (1)
- neuropathy (1)
- neuropilin-1 (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neuropsychological impairment (1)
- neuropsychology (1)
- neurosurgery (1)
- neurotrophins (1)
- neurovascular bundle preservation (1)
- neutral ceramidase (Asah2) (1)
- neutral sphingomyelinase (Smpd3) (1)
- neutralization (1)
- neutralizing antibodies (1)
- neutropenia (1)
- new miRNA functions (1)
- newborn infant (1)
- newborn screening (1)
- next-generation sequencing (1)
- nicotinic acetylcholine receptors (1)
- nintedanib (1)
- nitro-fatty acids (1)
- nitrogen dioxide (1)
- nitrogen oxides (NOx) (1)
- niños (1)
- nocardia (1)
- nocardiosis (1)
- nociception (1)
- nodular lymphocyte predominant Hodgkin lymphoma (1)
- nodular sclerosis (1)
- noise intervention measures (1)
- non - pharmacological anti-infective measures (1)
- non-Poissonian (1)
- non-ST-segment elevation acute coronary syndrome (1)
- non-canonical (1)
- non-classical adhesion molecule (1)
- non-communicable disease (1)
- non-communicable diseases (1)
- non-homologous end joining (1)
- non-invasive brain stimulation (1)
- non-invasive fibrosis assessment (1)
- non-linear dynamics (1)
- non-malignant hematological diseases (1)
- non-receptor tyrosine kinase (nRTK) (1)
- non-sensory bias (1)
- non-sexual (1)
- non-small cell lung cancer (1)
- non-small-cell lung cancer (1)
- non-spatial processing (1)
- nonalcoholic fatty liver disease (1)
- nonalcoholic steatohepatitis (1)
- noncoding RNA (1)
- noninterventional (1)
- nonnucleoside polymerase inhibitor (1)
- nonrandom connectivity (1)
- nonviral gene delivery (1)
- non‐selective beta‐blocker (1)
- non‑Hodgkin's lymphoma (1)
- novel H1N1 influenza (1)
- novel psychoactive substance (1)
- nuclear envelope (1)
- nuclear hormone receptor (1)
- nuclear import (1)
- nuclear pore complex (1)
- nuclear translocation (1)
- nucleotide analogue (1)
- nucleotide metabolism (1)
- nucleus accumbens (1)
- nursery school students (1)
- nursery students (1)
- nurses (1)
- nutrient deprivation (1)
- obese (1)
- objecitvity (1)
- object perception (1)
- object tracking (1)
- observational cohort study (1)
- occupational factors (1)
- occupational stress (1)
- ocriplasmin (1)
- off-pump surgery (1)
- offene Fragen (1)
- offset times (1)
- oksidacioni stres (1)
- older patients (1)
- older people (1)
- oligodendrocyte (1)
- oligomerization (1)
- olivo-ponto-cerebellar atrophy (OPCA) (1)
- omalizumab (1)
- omphalocele (1)
- oncogenes (1)
- oncological gastrectomy (1)
- oncological outcome (1)
- oncolytic virotherapy (1)
- oncomodulation (1)
- one anastomosis gastric bypass (1)
- one health (1)
- online information processing (1)
- online learning (1)
- online reasoning patterns (1)
- online survey (1)
- online teaching (1)
- open-source (1)
- operative (1)
- optical coherence tomography (1)
- optical imaging (1)
- oral and maxillofacial surgery (1)
- oral anticoagulation (1)
- oral cancer (1)
- oral enzyme combination (1)
- oral kallikrein inhibitor (1)
- oral squamous cell carcinoma (1)
- organ dysfunction (1)
- organ failure (1)
- organ of Corti (1)
- organisation of health services (1)
- organizational development (1)
- organophosphate flame retardants (OFR) (1)
- organotypic slice cultures (1)
- orientation (1)
- orientation selectivity (1)
- orthodeoxia (1)
- orthodontic mini‐implant (1)
- orthodontist (1)
- orthopaedic surgery (1)
- orthopic liver transplantation (1)
- oscillation (1)
- oscillator (1)
- oseltamivir (1)
- osteogenic sarcoma cells (1)
- osteoimmunological changes (1)
- osteopenia (1)
- osteoporosis treatment (1)
- osteotomy (1)
- ostium (1)
- otoferlin (1)
- ouabain (1)
- outcome parameter (1)
- oval split ring resonator (1)
- ovary (1)
- overall survival (OS) (1)
- overreaching markers (1)
- own-face perception (1)
- oxLDL (1)
- oxidised lipids (1)
- oxygen (1)
- oxygen metabolism (1)
- p14 (1)
- p16 (1)
- p21 phosphorylation (1)
- p21 stability (1)
- p21-activated kinase 2 (1)
- p22phox (1)
- p38 (1)
- p44/42 MAPK (1)
- p53 activator (1)
- p62 (1)
- p67phox (1)
- p73 (1)
- p75 (1)
- p97 (1)
- pCREB (1)
- pSMAD2 (1)
- pacemaker implantation (1)
- pack-years (PY) (1)
- paclitaxel sensitization (1)
- paediatric (1)
- paediatric nephrology (1)
- pain genetics (1)
- pain management (1)
- pain medication (1)
- pain questionnaire (1)
- pain research (1)
- pain target (1)
- pain, dorsal root ganglia (1)
- paired continuous theta burst stimulation (1)
- palbociclib (1)
- palmitoylation (1)
- pancreatic surgery (1)
- pandemic preparedness (1)
- papilloma (1)
- parameter estimation (1)
- parasite identity (1)
- parathormone (PTH) (1)
- parenting (1)
- parenting students (1)
- paricalcitol (1)
- parietal cortex (1)
- parkinson’s disease (1)
- parsley (1)
- participation (1)
- particle size distribution (1)
- particulate matter (PM) (1)
- passive immunization (1)
- passive reading paradigm (1)
- passive smoke (1)
- patency (1)
- patent (1)
- patent foramen ovale (1)
- pathogenesis (1)
- pathology (1)
- patient and public involvement (1)
- patient centered care (1)
- patient perspective (1)
- patient preference (1)
- patient preferences (1)
- patient questionnaire (1)
- patient study (1)
- patient-derived xenograft (1)
- patient-reported outcome measure (1)
- patient-reported outcomes (1)
- patients (1)
- patients' experience (1)
- patient‐centred outcomes (1)
- patient’s desires (1)
- patient’s perspective (1)
- pattern (1)
- patterns of progression (1)
- paxilline (1)
- pazopanib (1)
- peanut allergy (1)
- pediatric (1)
- pediatric cancer (1)
- pediatric epilepsy (1)
- pediatric eye screening (1)
- pediatric patients (1)
- pediatrics (1)
- pedicle screws (1)
- peficitinib (1)
- peg-interferon lambda (1)
- peginterferon (1)
- peginterferon-α (1)
- pelvic injury (1)
- pelvic ring fracture (1)
- pentafluorothio group (1)
- pentose phosphate pathway (1)
- perceptual memory (1)
- perceptual organization (1)
- perforin (1)
- performance assessment (1)
- performance evaluation (1)
- performance-based funding allocation (1)
- perfusion-weighted imaging (1)
- peri-implantitis (1)
- pericardial empyema (1)
- pericarditis (1)
- pericytes (1)
- perinasal skin cancer (1)
- perinatal HIV infection (1)
- perineurium (1)
- perio-prosthetic joint infection (1)
- periodontal disease progression (1)
- periodontal diseases (1)
- periodontal probing, (1)
- periodontal risk assessment (1)
- periodontal risk calculator (1)
- perioperative ischemia (1)
- perioperative mortality (1)
- perioperative outcome (1)
- perioperative period (1)
- peripheral arterial disease (1)
- peripheral blood mononuclear cells (1)
- peripheral blood stem cell transplant (1)
- peripheral nerve (1)
- peripheral vascular diseases (1)
- perirenal (1)
- peritoneal carcinomatosis (1)
- peri‐implant lesions (1)
- peri‐implant probing (1)
- peri‐implantitis therapy (1)
- persistent atrial fibrillation (1)
- persisting pain (1)
- person-oriented approach (1)
- personalised therapy (1)
- personalized oncology (1)
- pertuzumab (1)
- pervasive developmental disorders (1)
- pessary (1)
- pet rabbit (1)
- phage (1)
- phage display (1)
- phage therapy (1)
- phagocytes (1)
- pharmacist (1)
- pharmacoepidemiology (1)
- pharmacogenetics (1)
- pharmacogenomics (1)
- pharmacologic vitreolysis (1)
- pharmacology (1)
- phase 2 clinical trials (1)
- phase 3 study (1)
- phase II trial (1)
- phase III (1)
- phase coupling (1)
- phase-1 (1)
- phenolics (1)
- phenotype (1)
- phenotype/genotype relation (1)
- phenotypic screening (1)
- phenotypic spectrum (1)
- phenylephrine (1)
- phonological processing (1)
- phosphatases (1)
- phosphatidylinositols (1)
- phosphorus (1)
- phosphorylation (1)
- photoaging (1)
- photodynamic therapy (1)
- phylogenetic analysis (1)
- physical activity counseling (1)
- physical activity promotion (1)
- physical activity recommendations (1)
- physiotherapy (1)
- pibrentasvir (1)
- pictilisib (1)
- pig (1)
- pigs (1)
- pilot study (1)
- pineal (1)
- piperidone (1)
- pirinixic acid (1)
- pirinixic acid derivative (1)
- pitch perception (1)
- pivalate (1)
- pivoloyl (1)
- pixantrone (1)
- placement (1)
- plant growth (1)
- plant resistance (1)
- plant-insect interactions (1)
- plaque psoriasis (1)
- plasma membrane MICA (1)
- plasma-derived factor VIII concentrate, prophylaxis (1)
- plasminogen (1)
- plastic (1)
- platelet (1)
- platelet aggregation (1)
- platelet count (1)
- platelet lysate (1)
- platelet rich plasma (1)
- platform switching (1)
- platform-switched (1)
- platypnea (1)
- pleiotropin (1)
- pleomorphic xanthoastrocytoma (1)
- pleuropericarditis (1)
- plus-tip (1)
- pneumocystis carinii (1)
- pneumocystis pneumonia (1)
- pneumonia (1)
- podocytes (1)
- poetry (1)
- point shear wave elastography (1)
- pol g (1)
- polarization (1)
- polishing (1)
- pollen allergy (1)
- polo-like kinase (1)
- polo-like kinase 3 (1)
- poly(I:C) (1)
- poly-L-lysine (1)
- polyamines/metabolism (1)
- polycyclic aromatic hydrocarbon (1)
- polycystic kidney (1)
- polydipsia (1)
- polyethylenimine (1)
- polylactic acid (PLA) (1)
- polylactide (1)
- polyomavirus (1)
- polyomavirus (MCPyV) (1)
- polypharmacology (1)
- polyphenols (1)
- polysomnography (1)
- polysorbate 20 (1)
- polyuria (1)
- poor condition subarachnoid hemorrhage (1)
- popliteal artery (1)
- population-based (1)
- population-based surveillance (1)
- porcine (1)
- portosystemic shunt (1)
- posaconazole (1)
- post hoc study (1)
- post-liver transplantation management (1)
- post-translational modifications (PTMs) (1)
- post-transplantation lymphoproliferative disease (1)
- post-traumatic (1)
- post-traumatic osteoarthritis (1)
- posterior fossa masses (1)
- posterior parietal cortex (1)
- posterior vitreous detachment (1)
- postmortem interval (1)
- postnatal neurogenesis (1)
- postoperative delirium (1)
- posttranslational modification (1)
- posttransnational modification (1)
- posttraumatic inflammation (1)
- post‐traumatic stress disorder (1)
- potassium channels (1)
- power dynamics (1)
- ppi1 (1)
- practical exercises (1)
- pranlukast (1)
- pre-clinical models (1)
- pre-emptive allogeneic hematopoietic stem cell transplantation (1)
- pre-school asthma (1)
- preclinical (1)
- preclinical semesters (1)
- preconditioning (1)
- prediabetes (1)
- predialysis (1)
- prediction model (1)
- predictive biomarkers (1)
- predictive timing (1)
- predictive validity (1)
- pregnant (1)
- premature infant (1)
- premature transcript termination (1)
- premotor cortex (1)
- preoperative anaemia management (1)
- preoperative assessment (1)
- preoperative preparation (1)
- preparation (1)
- preprocedure prophylaxis (1)
- preschool asthma (1)
- preschool children (1)
- preschool health examination (1)
- presenilin (PS)/gamma-secretase activity (1)
- pressure (1)
- pressure cycling technology (1)
- pressure ulcer treatment (1)
- pressurized intraperitoneal aerosol chemotherapy (PIPAC) (1)
- preterm (1)
- pretreatment (1)
- prevalence of hysterectomy (1)
- prevent smoking (1)
- preventive medicine (1)
- primary biliary cirrhosis (1)
- primary biliary diseases (1)
- primary brain tumors (1)
- primary healthcare (1)
- primary immunodeficiency (PID) (1)
- primary motor cortex (1)
- primary motor cortex (M1) (1)
- primary mouse proximal tubular cells (1)
- primary prostate cancer (1)
- primary tubular cells (1)
- prior knowledge (1)
- proactive aggression (1)
- proanthocyanidin (1)
- procedural safety (1)
- process mining (1)
- productivity (1)
- progenitor (1)
- progeria (1)
- progesterone (1)
- progestin (1)
- prognosis research (1)
- prognostic biomarker (1)
- prognostic factor (1)
- programmed cell death (1)
- programmed cell death ligand 1 (1)
- programmed cell death protein 1 (1)
- progranulin (1)
- progression-free survival (PFS) (1)
- progressive myoclonus epilepsy (1)
- progressive neoplastic disease (1)
- proinflammatory microenvironment (1)
- promotion index (1)
- pronephric development (1)
- prophylactic vaccine (1)
- propofol anesthesia (1)
- proprotein convertase subtilisin/kexin type 9 inhibition (1)
- prospective memory (1)
- prospective studies (1)
- prostaglandin E2 (1)
- prostate and breast cancer cell lines (1)
- prostate brachytherapy (1)
- prostate cancer cells (1)
- prostate volume (1)
- prostate-specific antigen (1)
- prostatic cancer (1)
- proteases (1)
- protein C (1)
- protein kinase D (1)
- protein kinases (1)
- protein phosphatase 1 (PP1) inhibition/activation (1)
- protein phosphorylation (1)
- protein stability (1)
- protein tagging (1)
- protein transduction (1)
- protein/lentiviral transduction (1)
- protein–protein interactions (1)
- proteoglycans (1)
- proteostasis (1)
- proto-oncogene proteins c-akt (1)
- protocol compliance (1)
- proton density (1)
- proton pump inhibitors (1)
- proximal tubule cells (1)
- pruritus (1)
- pseudoexfoliative syndrome (1)
- psoriatic (1)
- psychiatric disorders (1)
- psychiatry (1)
- psycho-oncology (1)
- psychological (1)
- psychological distress (1)
- psychological model (1)
- psychological questionnaires (1)
- psychometric properties (1)
- psychometrics (1)
- psychosocial adjustment (1)
- psychosocial stress (1)
- psychotherapy (1)
- pteridine (1)
- public health department (1)
- public health. (1)
- public mental health (1)
- publication (1)
- pulmonary arterial hypertension (1)
- pulmonary endarterectomy (1)
- pulmonary inflammation (1)
- pulmonary nocardiosis (1)
- pulse labeling (1)
- pulse-spreading harmonic complex (1)
- pupil dilation (1)
- pupillary reactivity (1)
- putrescine/metabolism (1)
- pyramidal cell (1)
- qPCR (1)
- qRT-PCR (1)
- qRT-PCR detection (1)
- quality control (1)
- quality indicators (1)
- quality management (1)
- quality of care (1)
- quality of health care (1)
- quantification (1)
- quantitative T1 mapping (1)
- quantitative T1‐difference maps (1)
- quantitative mass spectrometry (1)
- quantitative proteomics (1)
- quantitative sensory testing (1)
- quantum biology (1)
- quantum neurobiology (1)
- rRNA (1)
- racket sports (1)
- radiation damage response (1)
- radiation oncology (1)
- radiation theraphy (1)
- radiation therapy (1)
- radiation-induced leukemia (1)
- radical oxygen species (1)
- radical prostatecomy (1)
- radical scavenging chemicals (1)
- radiofrequency (1)
- radiofrequency ablation (1)
- radioimmunotherapy (1)
- radioimmunotherpay (1)
- radiological (1)
- radiomic (1)
- radionuclide imaging (1)
- radioresponse (1)
- radiotherapy resistance (1)
- radixin (1)
- radon therapy (1)
- randomised controlled trial (1)
- randomized (1)
- randomized controlled trial (1)
- rare disease (1)
- rare disesases (1)
- rare variant (1)
- rare variants (1)
- rat femur defect (1)
- rat model (1)
- rct (1)
- re-emerging virus (1)
- re-transplantation (1)
- reactivation (1)
- reactive aggression (1)
- reactive oxygen species (ROS) (1)
- readmission rates (1)
- reaktivne vrste kiseonika (1)
- real-world (1)
- real-world evidence (1)
- receptor (1)
- receptor for advanced glycation end product (RAGE) (1)
- receptor tyrosine kinase (1)
- recertification (1)
- recombinant vesicular stomatitis virus‐Zaire ebolavirus (1)
- recommendation (1)
- recurrence (1)
- recurrent chromosomal translocations (1)
- recurrent laryngeal nerve palsy (1)
- recurrent mutations (1)
- recurrent optic neuritis (1)
- red blood cells (1)
- redox (1)
- redox signalling (1)
- redox-linked proton translocation (1)
- redundancy (1)
- redundant information (1)
- referred pain (1)
- reflexes (1)
- refractory aGvHD (1)
- registry for primary immunodeficiency (1)
- regorafenib (1)
- regorafenib csf concentration (1)
- regulation (1)
- regulatory T cell (1)
- regulatory T cells (1)
- relapsing fever (1)
- relapsing–remitting (1)
- relaxation (1)
- relaxometry (1)
- reliable change index (1)
- remifentanil (1)
- remission (1)
- remote ischemic preconditioning (1)
- remote monitoring (1)
- removal (1)
- renal failure (1)
- renal impairment (1)
- renal ischemia reperfusion injury (1)
- renal tubular cells (1)
- renal tubular epithelial cells (1)
- renin-angiotensin system (1)
- reorganization (1)
- repeat DMEK (1)
- repeat biopsy (1)
- repeated (1)
- reperfusion injury (1)
- repetition suppression (RS) (1)
- repetitive firing (1)
- repetitive transcranial magnetic stimulation (1)
- reproduction biology (1)
- repsonse process patterns (1)
- requirements analysis (1)
- research consortium (1)
- research in academic medicine (1)
- resective surgery (1)
- reserve substance (1)
- reservoir computing (1)
- resilience (1)
- resistance-associated substitutions (RAS) (1)
- resolution (1)
- resonance (1)
- resource utilization (1)
- respiratory complex I (1)
- respiratory disease (1)
- respiratory failure (1)
- restenosis (1)
- resting EEG (1)
- resting-state functional connectivity (1)
- resting‐state (1)
- restless legs syndrome (1)
- restrictive atrial communication (1)
- resuscitation (1)
- resveratrol (1)
- retina (1)
- retinal degeneration (1)
- retinal detachment (1)
- retinoic acid-related orphan receptor gamma t (1)
- retrospective (1)
- retrospective trial (1)
- retuximab (1)
- revalidation (1)
- reverse transcription (1)
- rhabdomyosarcomas (1)
- rheumatoid (1)
- rhodocetin-αβ (1)
- rhyme (1)
- rhythm (1)
- rhythmic aptitude (1)
- rhythms (1)
- ribociclib (1)
- ribosome-inactivating protein (1)
- rice husk (1)
- ridge preservation (1)
- right heart catheter (1)
- right ventricular function (1)
- riociguat (1)
- risk assessment (1)
- risk communication (1)
- risk factor progression (1)
- risk genes (1)
- risk management (1)
- risk score (1)
- rivaroxaban (1)
- robotic heart surgery (1)
- robotik kalp cerrahis (1)
- rolipram (1)
- romske ženske (1)
- root coverage (1)
- rosacea (1)
- rosetting T cells (1)
- roughness (1)
- rub-in technique (1)
- running (1)
- running wheel (1)
- rural health program (1)
- sCD163 (1)
- sCD206 (1)
- sE-cadherin (1)
- saliva (1)
- salvage radiotherapy (1)
- salvage therapy (1)
- sarcoma (1)
- sarcopenia (1)
- scaffold size (1)
- scaffolding proteins (1)
- scavenger receptor (1)
- schizophrenia spectrum (1)
- sciatic nerve (1)
- sciatic nerve injury (1)
- sclerosing cholangitis (1)
- sclerostin (1)
- scoping review (1)
- screening routine (1)
- screening test (1)
- screw augmentation (1)
- screw loosening (1)
- second mitochondria-derived activator of caspases mimetic (1)
- secondary cancer (1)
- secondary data analysis (1)
- secondary hyperparathyroidism (sHPT) (1)
- secondary schools (1)
- seed germination (1)
- segmentation (1)
- selectin (1)
- selection (1)
- selective attention (1)
- selective autophagy (1)
- selective autophagy receptor (1)
- selective mutism, (1)
- self-administration (1)
- self-citation (1)
- self-esteem (1)
- self-management support (1)
- self-organisation (1)
- self-organized criticality (1)
- self-schema (1)
- selfish genetic element (1)
- self‐expanding (1)
- semen (1)
- sensitization (1)
- sensorimotor exercise training (1)
- sensory deprivation (1)
- sensory neurons (1)
- sensory processing (1)
- sequential ALK-inhibitor therapy (1)
- serine palmitoyltransferase 2 (Sptlc2) (1)
- serology (1)
- serositis (1)
- serotonin (1)
- serum (1)
- serum albumin deficiency (1)
- serum concentrations (1)
- severe acute respiratory syndrome coronavirus (1)
- severe asthma (1)
- severe congenital neutropenia (1)
- severe uncontrolled asthma (1)
- severe vitamin D deficiency (1)
- sexual revolution (1)
- sexually transmitted diseases (1)
- sexually transmitted infection (1)
- sex‑determining region Y-box 11 (1)
- sham (1)
- shedding (1)
- shell ginger (1)
- shock (1)
- shock filter (1)
- short linear motifs (SLiMs) (1)
- short tandem repeats (1)
- short-chain ceramide (1)
- short-term prophylaxis (1)
- shortage of family doctors (1)
- shortening of treatment (1)
- shrinkage (1)
- siRNA delivery (1)
- siRNA/RNAi (1)
- sialitis (1)
- sickle cell anemia (1)
- signal transducer and activator of transcription (1)
- signal transducer and activator of transcription 3 (1)
- signal transducer and activator of transcription-1 (1)
- signalosome (1)
- silence interfering RNA (1)
- silicone device (1)
- silk fibroin (1)
- simeprevir (1)
- single best choice question (1)
- single choice questions (1)
- single nucleotide polymorphism (1)
- single-port cholecystectomy (1)
- single‐photon emission (1)
- sinus rhythm (1)
- sirtuin1 (1)
- sirtuins (1)
- six-step technique (1)
- size of cigarettes (1)
- skill mix (1)
- skills shortage (1)
- skin conductance (1)
- skin inflammation (1)
- skin involvement (1)
- sleep apnea (1)
- sleepiness (1)
- slow-wave rhythms (1)
- slowing (1)
- smac mimetic (1)
- small compounds (1)
- small leucine-rich proteoglycan (1)
- small molecule inhibitor (1)
- small molecules (1)
- small-angle neutron scattering (1)
- smoking in pregnancy (1)
- social cognitive (1)
- social determinants (1)
- social isolation (1)
- social psychiatry (1)
- socioeconomic status (1)
- sodium bituminosulfonate (1)
- sodium channels (1)
- sofosbuvir (1)
- soft drinks (1)
- soft skills (1)
- soft tissue sarcoma (STS) (1)
- solid tumors (1)
- solitary pulmonary nodule (1)
- soluble epoxide hydrolase (1)
- soluble tumor necrosis factor receptor (1)
- solvent (1)
- solvent displacement (1)
- somatic mutations (1)
- somatoform disorder (1)
- somatostatin interneurons (1)
- sonic hedgehog (1)
- sonic hedgehog signaling (1)
- sonidegib (1)
- sound analyses (1)
- sound-induced flash illusion (1)
- sox genes (1)
- spatial (1)
- spatial interactions (1)
- spatial processing (1)
- species differences (1)
- spectral activity (1)
- spectrin (1)
- spectroscopy (1)
- speech rhythm (1)
- speech segmentation (1)
- spermidine (1)
- sphinganine 1-phosphate (1)
- sphingolipid metabolism (1)
- sphingolipid sphingosine-1-phosphate (1)
- sphingosine 1-phoshate (1)
- sphingosine 1-phosphate antagonistst/inhibitors (1)
- sphingosine 1-phosphate metabolism (1)
- sphingosine 1-phosphate receptor (1)
- sphingosine 1-phosphate signaling (1)
- sphingosine kinase (1)
- sphingosine kinase 1 (1)
- sphingosine-1-phosphate receptor (1)
- sphingosine-1-phosphate receptor 5 (1)
- spider toxin (1)
- spike train (1)
- spike train analysis (1)
- spike-in SILAC (1)
- spike-timing dependent plasticity (1)
- spike-timing dependent-like plasticity (1)
- spinal fusion (1)
- spindle assembly (1)
- spindle mispositioning (1)
- spine (1)
- spinster homology protein 2 (Spns2) (1)
- spiral ganglion (1)
- spiral ganglion cell (1)
- spiral ganglion cells (1)
- spirochete (1)
- spirometry (1)
- spontaneous portosystemic shunt (1)
- sport (1)
- sports (1)
- squamous cell carcinoma (1)
- squamous cell carcinoma of head and neck (1)
- staff capacity (1)
- staff fluctuation (1)
- stage (1)
- stage II/III colorectal cancer (1)
- standard value (1)
- standardization (1)
- standardized regression-based change norms (1)
- starvation (1)
- state exams (1)
- statedependence (1)
- statistical parametric mapping (1)
- steatosis (1)
- stellate reticulum (1)
- stem cell niche (1)
- stem cell therapy (1)
- stem cells (1)
- stem/progenitor cell expansion (1)
- stenosis (1)
- stenosis quantification (1)
- stent (1)
- stereoselectivity (1)
- stereotactic (1)
- sterile abscess (1)
- sterile α motif (SAM) (1)
- steroid control of aging (1)
- steroid-resistant aGvHD (1)
- sterol regulatory element binding protein-2 (1)
- stimulation (1)
- stimulus coding (1)
- stiripentol (1)
- stopping rule (1)
- stratification (1)
- strength (1)
- strength and conditioning mesocycle (1)
- strength training (1)
- stretching (1)
- stroke prevention (1)
- stromal-derived factor 1 (1)
- structural biology and molecular biophysics (1)
- structural covariance (1)
- structural equation modeling (1)
- structural plasticity (1)
- structure (1)
- structure–activity relationships (1)
- studentisches Lernverhalten (1)
- study protocol (1)
- subcutaneous fat (1)
- subcutaneous immunotherapy (1)
- subject selection (1)
- subjunctivity (1)
- sublingual immunotherapy (1)
- substance abuse disorder (1)
- subventricular zone (1)
- subventricular zone (SVZ) (1)
- success rate (1)
- succession (1)
- suicidality (1)
- suicide (1)
- sulfasalazine (1)
- sulfur dioxide (1)
- sulfur globules (1)
- superficial femoral artery (1)
- superiority (1)
- supervised machine-learning (1)
- supervision (1)
- supervisión (1)
- suplementacija (1)
- supplementary motor area (1)
- supplementary motor area (SMA) (1)
- supplementation (1)
- support vector machines (1)
- suprapubic catheter (1)
- surface marker reversion (1)
- surface-based morphometry (1)
- surfactant (1)
- surgical margin (1)
- surveillance (1)
- survey (1)
- sympathetic nervous system (1)
- sympathicus (1)
- symptoms (1)
- synapse (1)
- synaptic plasticity (1)
- synaptic signaling (1)
- syncope (1)
- synergistic interaction (1)
- synovial fibroblast (1)
- synoviocyte (1)
- synovium (1)
- syntax (1)
- synuclein (1)
- systematic biopsy (1)
- systematisches Review (1)
- systemic antibiotics (1)
- systemic inflammation (1)
- systemic lupus erythematosus (1)
- systemic sclerosis (1)
- szentiamide (1)
- t(6;9) (1)
- t-distributed stochastic neighbor embedding (1)
- tDCS (1)
- tRNA (1)
- tacrolimus (1)
- tailored treatment schedule (1)
- talent development (1)
- talent identification (1)
- tandem mass spectrometry (1)
- target variability (1)
- targeted biopsy (1)
- targeting (1)
- task set (1)
- task-switching training (1)
- tea (1)
- teach-the-teacher (1)
- teacher training (1)
- teacher's training (1)
- teachers' training (1)
- teaching competencies (1)
- teaching skills (1)
- tear (1)
- tehnika dekalcifikacije (1)
- telmisartan (1)
- temporal correlations (1)
- temsirolimus-resistance (1)
- terapia cognitivo conductual enfocada en trauma (1)
- teratoma (1)
- terebridae venom (1)
- terminology (1)
- test protocol (1)
- testicular cancer (1)
- testing (1)
- testis (1)
- testosterone (1)
- tetracycline (1)
- tetraether lipid (1)
- tetrahydrobiopterin (1)
- tetrahydrocannabinol (1)
- thalassemia (1)
- thalidomide (1)
- the allen institute for brain science (1)
- the small molecule inhibitor MRIA9 (1)
- theory of sexuality (1)
- theranostics (1)
- therapeutics (1)
- therapy at the end of life (1)
- thiazolidine and perhydrothiazine derivatives of aldophosphamide and I-aldophosphamide (1)
- thighplasty (1)
- thioredoxin (1)
- thiosulfate oxidation (1)
- third (1)
- thoracolumbar spine injury classification system (1)
- thoracolumbar trauma (1)
- three point bending test (1)
- three-dimensional analysis (1)
- three‐dimensional analysis (1)
- thrombocyte dysfunction (1)
- thrombocyte function (1)
- thrombocytopenia (1)
- thrombocytosis (1)
- thrombolysis (tPA) (1)
- thrombopenia (1)
- thrombopietin receptor agonist (1)
- thrombosis (1)
- thrombospondin-4 (1)
- thrombotic microangiopathy (1)
- thrombotic thrombocytopenic purpura (1)
- thyroglobulin mRNA (1)
- thyroid cancer (1)
- thyroid nodule (1)
- thyroid resection (1)
- thyroid surgery (1)
- tick (1)
- time-lapse imaging (1)
- tiotropium (1)
- tissue at risk (1)
- tissue engineering (1)
- tissue mechanics (1)
- tissue slice co-cultures (1)
- titanium (1)
- titanium particles (1)
- tobacco cessation (1)
- tobacco control (1)
- tobacco products (1)
- tobacco taxation (1)
- toc64 (1)
- tolerability (1)
- tolerance (1)
- toll-like receptors (1)
- tolvaptan (1)
- tomography (1)
- tongue edema (1)
- tooth (1)
- tooth autotransplantation (1)
- tooth transplantation (1)
- tooth wear (1)
- top-down (1)
- top-down processing (1)
- topical agent (1)
- topographic maps (1)
- top–down (1)
- total body score (1)
- total events (1)
- total flavonoids (1)
- total joint arthroplasty (TJA) (1)
- total phenols (1)
- toxic hemisphere syndrome (1)
- toxin B (1)
- tpileptogenesis (1)
- tracheobronchomalacia (1)
- tracking (1)
- tractography (1)
- traffic accident (1)
- traffic emissions (1)
- trafficking (1)
- training effects (1)
- training program (1)
- training transfer (1)
- trans-Golgi network (1)
- transapical aortic valve replacement (1)
- transarterial chemoembolization (TACE) (1)
- transbronchial biopsy (TBB) (1)
- transcatheter aortic valve replacement (1)
- transcatheter aortic valve replacement (TAVR) (1)
- transcatheter aortic valve replacement (TAVR), aortic valve stenosis (AS) (1)
- transcatheter closure (1)
- transcranial alternating current stimulation (tACS) (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional profiling (1)
- transcriptional regulation of autophagy (1)
- transcriptome analysis (1)
- transcriptomics (1)
- transdifferentiation (1)
- transfemoral (1)
- transfer (1)
- transforming growth factor beta (1)
- transforming growth factor beta (TGF-β) (1)
- transforming growth factor-β (1)
- transgelin (1)
- transgenically augmented CAR NK cell (1)
- transient interactions (1)
- transient receptor potential channels (1)
- transient virtual lesion (1)
- transition (1)
- transjugular intrahepatic portosystemic shunt (TIPS) (1)
- transjugular portosystemic intrahepatic (1)
- transketolase-like protein 1 (1)
- translation (1)
- translational cancer research (1)
- translational medical research (1)
- translational medicine (1)
- translational reseach (1)
- translocation partner genes (1)
- translocon (1)
- transmission and vector control (1)
- transmission routes (1)
- transmitted founder virus (1)
- transportation (1)
- transposition (1)
- transrectal prostate biopsy (1)
- transsexualism (1)
- transurethral catheter (1)
- transverse axis (1)
- traumafocused cognitive behavioural therapy (1)
- traumatic brain injury (1)
- traumatic brain injury (TBI) (1)
- treatment choice (1)
- treatment preference (1)
- treatment-related changes (1)
- treatment-resistant (1)
- trehalose (1)
- triathlon (1)
- tricalcium phosphate (1)
- trichostatin A (1)
- trigeminal pain (1)
- triple therapy (1)
- trochee (1)
- trophiclevel (1)
- trophoblastic cell lines (1)
- trophoblasts (1)
- tropical marine sponges (1)
- troponin (1)
- trust (1)
- trustworthy AI (1)
- tryptophan (1)
- tuberculosis epidemiology (1)
- tuberous sclerosis complex (1)
- tubular regeneration (1)
- tuft cells (1)
- tumor (1)
- tumor adhesion (1)
- tumor cell proliferation (1)
- tumor dissemination (1)
- tumor growth in xenografts (1)
- tumor immune escape (1)
- tumor immune evasion (1)
- tumor invasion (1)
- tumor metabolism (1)
- tumor microenviroment (1)
- tumor microenvironment (TME) (1)
- tumor migration (1)
- tumor necrosis factor converting enzyme (1)
- tumor necrosis factor receptor superfamily member 9 (1)
- tumor pain (1)
- tumor proliferation (1)
- tumor response (1)
- tumor stroma (1)
- tumor weight (1)
- tumor xenograft (1)
- tumor-infiltrating-lymphocytes (1)
- tumor-specific antigen expressing dendritic cells (1)
- tumor‐associated macrophages (1)
- tumour (1)
- tumour growth (1)
- tumour immunology (1)
- tumour microenvironment (1)
- tumour-infiltrating lymphocytes (1)
- two-tissue compartment model (1)
- type 1 diabetes (1)
- type B (1)
- type I interferon (1)
- type I interferons (1)
- type I interferons (IFNs) (1)
- type-1-diabetes (1)
- tyrosinase inhibitor (1)
- tyrosine kinase inhibitors (1)
- tyrosine kinase inhibitors. (1)
- ubiquitin coat (1)
- ubiquitin receptor (1)
- ubiquitin-binding zinc finger (1)
- ulcerative colitis (1)
- ultra-high field MRI (1)
- unanticipated (1)
- uncertainty (1)
- understudied kinase (1)
- unfolded protein response (1)
- unguided (1)
- unilateral hip osteoarthritis (1)
- unique information (1)
- university hospitals (1)
- upper gastrointestinal cancer (1)
- urachal cancer (1)
- urethral stricture (1)
- urethroplasty (1)
- urinary diversion (1)
- urinary tract development (1)
- ursodeoxycholic acid (1)
- uterine cervical cancer (1)
- vaccination rates (1)
- vaccine acceptance (1)
- vaccine trial (1)
- vacuuming (1)
- vadimezan (1)
- validation studies (1)
- value frameworks (1)
- vancomycin (1)
- variability (1)
- vascular (1)
- vascular calcification (1)
- vascular complications (1)
- vascular disease (1)
- vascular disrupting agents (1)
- vascular dysfunction and inflammation (1)
- vascular endothelial growth factor (1)
- vascular endothelial growth factor receptor (1)
- vascular endothelial growth factor receptor 2 (1)
- vascular remodeling (1)
- vascular smooth muscle (1)
- vascular smooth muscle cells (1)
- vascular surgery (1)
- vasculogenic mimicry (1)
- vasoconstriction (1)
- vasodilation (1)
- vasopressin (1)
- vector-borne disease (1)
- velpatasvir (1)
- veneering porcelain (1)
- ventilation modes (1)
- ventral striatum (1)
- ventricular zone (VZ) (1)
- ventriculoperitoneal shunt (1)
- venturesomeness (1)
- versican (VCAN) (1)
- vertebrates (1)
- vertebroplasty (1)
- verzweigtkettige Aminosäuren (1)
- vesicovaginal septum (1)
- vesicular glutamate transporter 2 (1)
- vessel density (1)
- vessel-associated mural cells (1)
- vestibular schwannoma (1)
- viability (1)
- videos (1)
- vigilance (1)
- vincristine (1)
- violence (1)
- viral gene transfer (1)
- viral infection (1)
- viral tracing (1)
- viral vectors (1)
- virological failure (1)
- virulence (1)
- virus (1)
- virus-like particles (1)
- viscero-cutaneous (1)
- vision (1)
- vismodegib (1)
- vismodegib (GDC-0449) (1)
- visual cortex (1)
- visual illusion (1)
- visual priming (1)
- visual short-term memory (1)
- visual system (1)
- visuo-spatial attention (1)
- visuospatial attention (1)
- vitamin D deficiency (1)
- vitamin D metabolites (1)
- vitamin D receptor (1)
- vitamin D supplementation (1)
- vitamin D target genes (1)
- vitamin D3 (1)
- vitamin Dmetabolism (1)
- vitreomacular traction (1)
- vitreous samples (1)
- vocal cord dysfunction (1)
- vocal cord palsy (1)
- voice (1)
- volatile organic compounds (VOC) (1)
- volatile sedation (1)
- voltage sensitive dye imaging (1)
- voluntary training (1)
- von Willebrand disease (1)
- von Willebrand diseases (1)
- voxel-based morphometry (1)
- voxilaprevir (1)
- waking state (1)
- water parameter (1)
- wax layer (1)
- wear (1)
- western blotting (1)
- wheezing (1)
- white matter changes (1)
- white-matter (1)
- whole abdominal radiotherapy (1)
- whole genome sequencing (1)
- whole slide image (1)
- whole-brain modeling (1)
- wild animals (1)
- wild boar carcass (1)
- willingness to participate (1)
- winter survival (1)
- within-host viral modeling (1)
- women (1)
- words (1)
- work ability (1)
- work productivity (1)
- work-life balance (1)
- workplace health promotion (1)
- wound complications (1)
- xenobiotics (1)
- xenophagy (1)
- yeast-two-hybrid (Y2H) (1)
- yellow fever virus (1)
- yellow fever virus tropism (1)
- yield optimization (1)
- young people (1)
- youth football (1)
- zafirlukast (1)
- zebrafish development (1)
- zirconia (1)
- zymosan (1)
- Übernahme von Innovationen (1)
- Übertragungswege (1)
- Überwachung (1)
- ß-D-glucan (1)
- ß-tricalciumphosphate (1)
- α-amylase inhibitor (1)
- α-mannosidosis (1)
- α-particles (1)
- α-synuclein (1)
- αvβ3 integrin (1)
- β-catenin (1)
- β-lactamases (1)
- γH2AX (1)
- γδT cell (1)
- γ‐H2AX (1)
- μ-opioid receptor regulation (1)
- π-clamp (1)
- гепатит С (1)
- правила прекращения лечения (1)
- противовирусные препараты прямого действия (ПППД) (1)
- сокращение лечения (1)
- устойчивый вирусологический ответ (УВО) (1)
- “gatekeeper” mutation T315I (1)
- flow cytometry (1)
Institute
- Medizin (3562)
- Biowissenschaften (68)
- Georg-Speyer-Haus (59)
- Sonderforschungsbereiche / Forschungskollegs (56)
- Zentrum für Arzneimittelforschung, Entwicklung und Sicherheit (ZAFES) (56)
- Biochemie und Chemie (46)
- Pharmazie (46)
- Exzellenzcluster Makromolekulare Komplexe (45)
- Frankfurt Institute for Advanced Studies (FIAS) (43)
- Präsidium (34)
Background The Deltaretrovirus genus comprises viruses that infect humans (HTLV), various simian species (STLV) and cattle (BLV). HTLV-I is the main causative agent in adult T-cell leukemia in endemic areas and some of the simian T-cell lymphotropic viruses have been implicated in the induction of malignant lymphomas in their hosts. BLV causes enzootic bovine leukosis in infected cattle or sheep. During the past few years several new Deltaretrovirus isolates have been described in various primate species. Two new HTLV-like viruses in humans have recently been identified and provisionally termed HTLV-III and HTLV-IV. In order to identify a broad spectrum of Deltaretroviruses by a single PCR approach we have established a novel consensus PCR based on nucleotide sequence data obtained from 42 complete virus isolates (HTLV-I/-II, STLV-I/-II/-III, BLV). The primer sequences were based on highly interspecies-conserved virus genome regions. We used this PCR to detect Deltaretroviruses in samples from adult patients with a variety of rare T-cell neoplasms in Germany. Results: The sensitivity of the consensus PCR was at least between 10-2 and 10-3 with 100% specificity as demonstrated by serial dilutions of cell lines infected with either HTLV-I, HTLV-II or BLV. Fifty acute T-cell lymphoblastic leukemia (T-ALL) samples and 33 samples from patients with various rare mature T-cell neoplasms (T-PLL, Sezary syndrome and other T-NHL) were subsequently investigated. There were no cases with HTLV-I, HTLV-II or any other Deltaretroviruses. Conclusions: The results rule out a significant involvement of HTLV-I or HTLV-II in these disease entities and show that other related Deltaretroviruses are not likely to be involved. The newly established Deltaretrovirus PCR may be a useful tool for identifying new Deltaretroviruses.
Poster presentation: Hyperphosphorylation of tau is a characteristic of Alzheimer's disease (AD). Our group has established a model for tau hyperphosphorylation by mutating 10 residues from Ser/Thr to Glu to simulate the negative charge of phosphorylated residues ("pseudohyperphosphorylated (PHP)-tau"). In order to analyze temporal and spatial effects of hyperphosphorylation of tau in a systemic context, we have established transgenic mouse lines that express human wild-type (wt)- or PHP-tau under the control of the CamKIIalpha-promoter that leads to a forebrain specific moderate expression in neurons, i.e. the region where also tau-pathology in AD is abundant. For the evaluation of tau-induced changes in the transgenic mice, we quantified spine densities in the neocortex and hippocampus of transgenic mice. The spine densitiy was significantly increased in PHP-tau compared to wt-tau expressing mice. It is known that AD is associated with aberrant pre- and postsynaptic sprouting. Axonal sprouting is also observed in transgenic mice expressing mutated amyloid precursor protein (APP), which suggests that Abeta plays a significant role in this process. We deduce from our results, that (pseudo)-hyperphosphorylation of tau is sufficient to induce aberrant sprouting in the absence of Abeta. Analyses whether this sprouting is induced by pre- or postsynaptic changes and if functionally active synapses are formed are in progress. It will be interesting to determine if stabilization of these newly formed synapses slows or – in contrary – accelerates the progression of the disease. Sprouting as observed in our PHP-tau expressing mice is part of neuronal differentiation. One family of enzymes that is involved in cell differentiation are mitogen-acitvated protein kinases (MAPK). Western blot analysis was performed with brain lysates from transgenic mice to check whether PHP-tau induced sprouting is associated with MAPK activation. In fact, we also observed an increased activation of the MAPK ERK1/2 evident by phosphorylation of the residues Thr202 and Tyr204. ERK1/2 is also known to phosphorylate tau at sites characteristic for AD. Our results suggest the presence of a vicious circle by which (pseudo)-hyperphosphorylated tau activates ERK1/2 which in turn phosphorylates tau.
Poster presentation: The transcription factor NF-kappaB plays a central role in the development and maintenance of the central nervous system and its constitutive activation in neurons has been repeatedly reported. Previous work from our laboratories (poster presentation: Compartimentalized NF-kappaB activity in the axon initial segment) had revealed an intriguing clustering of activated IKKalpha/beta and other downstream elements of an activated NF-kappaB cascade (phospho-IkappaBalpha, phospho-p65(Ser536)) in the axon initial segment (AIS). Accumulation of certain voltage-gated sodium channels (Na(v)1.2), M-type potassium channels (KCNQ2) as well as cytoskeletal anchoring proteins (AnkyrinG) characterise the AIS. However, it is not yet clear how AIS-localized IKK gets activated and whether this can be connected to the constitutive activation of NF-kappaB. Long-term blockade of sodium channels with tetrodotoxin, potassium-channels with linopirdine or NMDA-receptors with MK-801 did not elicit any change upon the constitutive activation of the pathway. Strikingly, the occurrence of phosphorylated IkappaBalpha was even unaltered by 24 h of incubation with protein synthesis inhibitors. Others have reported that impairment of NF-kappaB inhibits neuritogenesis. In this line we observed that the early initiation of IkappaBalpha phosphorylation was susceptible to inhibition of IKK in DIV1–2 neurons. We therefore aim to identify the interaction partners of the activated IKK complex in the AIS. Proteomic methods such as co-immunoprecipitation analyses and mass-spectrometry will help us to identify the key players in the initiation of constitutive IKK phosphorylation and activation in neurons.
Poster presentation: The mammalian pineal organ is a peripheral oscillator, depending on afferent information from the so-called master clock in the suprachiasmatic nuclei of the hypothalamus. One of the best studied outputs of the pineal gland is the small and hydrophobic molecule melatonin. In all vertebrates, melatonin is synthesized rhythmically with high levels at night, signalling the body the duration of the dark period. Changes or disruptions of melatonin rhythms in humans are related to a number of pathophysiological disorders, like Alzheimer's disease, seasonal affective disorder or the Smith-Magenis-Syndrome. To use melatonin in preventive or curative interferences with the human circadian system, a complete understanding of the generation of the rhythmic melatonin signal in the human pineal gland is essential. Melatonin biosynthesis is best studied in the rodent pineal gland, where the activity of the penultimate and rate-limiting enzyme, the arylalkylamine N-acetyltransferase (AA-NAT), is regulated on the transcriptional level, whereas the regulatory role of the ultimate enzymatic step, achieved by the hydroxyindole O-methyltransferase (HIOMT), is still under debate. In rodents, Aa-nat mRNA is about 100-fold elevated during the night in response to adrenergic stimulation of the cAMP-signalling pathway, with AA-NAT protein levels closely following this dynamics. In contrast, in all ungulates studied so far (cow, sheep), a post-transcriptional regulation of the AA-NAT is central to determine rhythmic melatonin synthesis. AA-NAT mRNA levels are constantly elevated, and lead to a constitutive up-regulation of AA-NAT protein, which is, however, rapidly degraded via proteasomal proteolysis during the day. AA-NAT proteolysis is only terminated upon the nocturnal increase in cAMP levels. Similar to ungulates, a post-transcriptional control of this enzyme seems evident in the pineal gland of the primate Macaca mulatta. Studies on the molecular basis of melatonin synthesis in the human being are sparse and almost exclusively based on phenomenological data, derived from non-invasive investigations. Yet the molecular mechanisms underlying the generation of the hormonal message of darkness can currently only be deciphered using autoptic material. We therefore analyzed in human post-mortem pineal tissue Aa-nat and Hiomt mRNA levels, AA-NAT and HIOMT enzyme activity, and melatonin levels for the first time simultaneously within tissue samples of the same specimen. Here presented data show the feasibility of this approach. Our results depict a clear diurnal rhythm in AA-NAT activity and melatonin content, despite constant values for Aa-nat and Hiomt mRNA, and for HIOMT activity. Notably, the here elevated AA-NAT activity during the dusk period does not correspond to a simultaneous elevation in melatonin content. It is currently unclear whether this finding may suggest a more important role of the ultimate enzyme in melatonin synthesis, the HIOMT, for rate-limiting the melatonin rhythm, as reported recently for the rodent pineal gland. Thus, our data support for the first time experimentally that post-transcriptional mechanisms are responsible for the generation of rhythmic melatonin synthesis in the human pineal gland.
Poster presentation: Light is the main phase-adjusting stimulus of the circadian clock located in the suprachiasmatic nucleus (SCN). A candidate pathway transmitting photic information at the postsynaptic site in the SCN is the extracellular signal-regulated kinase (ERK 1/2) which has been previously shown to be an essential element in the photoentrainment of the circadian rhythm. An upstream activator of the ERK signalling route is the small intracellular GTPase Ras. Here we observed that endogenous Ras activity in the SCN was subjected to rhythmic changes, reaching maximum levels at the late subjective day and minimum levels at the late subjective night (CT22). In order to investigate if Ras would modulate the circadian cycle, we used transgenic mice expressing constitutively activated Val-12 Ha-Ras selectively in neurons (synRas mice). In these mice Ras activity was also cycling during the circadian rhythm yet, Ras activities were up-regulated at each time point measured. We investigated if this change in Ras activity translates into a behavioral phenotype by monitoring free-running activity rhythms under conditions of constant darkness. SynRas mice exhibited circadian rhythms in locomotor activities similar to WT mice. However, when challenged by applying a 15 minutes light pulse at CT22 to promote phase advance shifts, synRas mice were completely non-responsive. As a first step towards the possible intracellular mechanism of this behavioral change we analyzed ERK1/2 activities in more details: We found a 1,7-fold increase of circadian peak levels of ERK 1/2 activities at CT10 and CT14 in synRas mice, while at minimum levels (CT18, CT22) no differences were found between ERK1/2 activities of WT and synRas mice. In WT animals the 15 minutes light pulse at CT22 resulted in rapid up regulations of Ras, ERK1/2 and CREB activities as described previously by others. However, in correlation with the lack of a behavioral response, ERK1/2 but not Ras and CREB activities remained unchanged in synRas mice, suggesting that Ras-dependent and Ras-independent pathways may co-exist to regulate ERK1/2 and behavioral phase shifts in response to the acute light treatment. Next we investigated the length "tau" of the locomotor activity rhythm during constant darkness and found a slight shortening by about 10 minutes in synRas mice as compared to the WT littermates. Recently, "tau" has been discussed to be modulated by the interaction between glycogen synthase 3beta (GSK3beta) and a clock gene product (Per 2) that is involved in the determination of circadian phase durations. We describe here a down-regulation of GSK3beta phosphorylation in synRas mice as a possible mechanism of "tau" shortening. Taken together, cycling of Ras activity at elevated levels in the SCN during the circadian rhythm results in a distinct pattern of behavioral phenotype changes correlating with de-regulated ERK1/2 or GSK3beta activities.
Poster presentation: The transcription factor NF-kappaB plays a pivotal role in the development and maintenance of the central nervous system and its constitutive activation in neurons has been previously reported. NF-kappaB is post-translationally activated upon phosphorylation of the IkappaBalpha inhibitory protein by the activated IkappaB kinase (IKKalpha/beta) and the subsequent degradation of IkappaBalpha by the proteasome. Recently, we had demonstrated an unexpected accumulation of three components of the NF-kappaB cascade in the axon initial segment (AIS): Activated IKK, phosphorylated IkappaBalpha and phosphorylated-p65(Ser536). These are all associated with detergent-insoluble cytoskeletal components of the AIS. We observed further compartimentalization as pIKKalpha/beta primarily associated with the membrane cytoskeleton, whereas pIkappaBalpha was sequestered to fasciculated microtubules. Colchicine-induced depolymerization of microtubules was associated with reduced sequestration of pIkappaBalpha in the AIS, which could be blocked by use of proteasome inhibitors like Mg-132 or Lactacystin. Concurrently, enhanced nuclear immunoreactivity for the NF-kappaB subunit p65 was noted. Using NF-kappaB-dependent reporter gene assays, a significant increase in NF-kappaB activity was observed after depolymerization of microtubules and this was inhibited by the microtubule-stabilizing drug paclitaxel. The use of transiently transfected, photoactivatable-GFP p65 fusion proteins will allow us to specifically analyse the compartimentalized signal transduction pathways in unique spatial and temporal resolution. Taken together, these observations provide strong evidence for compartmentalized activation of NF-kappaB in the AIS and modulation of neuronal NF-kappaB activity by microtubule dynamics.
Poster presentation: Here we investigated the role of the amyloid precursor protein (APP) in regulation of Ca2+ store depletion-induced neural cell death. Ca2+ store depletion from the endoplasmic reticulum (ER) was induced by the SERCA (Sarco/Endoplasmic Reticulum Calcium ATPase) inhibitor thapsigargin which led to a rapid induction of the unfolded protein response (UPR) and a delayed activation of executioner caspases in the cultures. Overexpression of APP potently enhanced cytosolic Ca2+ levels and cell death after ER Ca2+ store depletion in comparison to vector-transfected controls. GeneChipR and RT-PCR analysis revealed that the expression of classical UPR chaperone genes was not altered by overexpression of APP.Interestingly, the induction of the ER stress-responsive pro-apoptotic transcription factor CHOP was significantly upregulated in APP-overexpressing cells in comparison to vectortransfected controls. Chelation of intracellular Ca2+ with BAPTA-AM revealed that enhanced CHOP expression after store depletion occured in a Ca2+-dependent manner in APPoverexpressing cells. Prevention of CHOP induction by BAPTA-AM and by RNA interference was also able to abrogate the potentiating effect of APP on thapsigargin-induced apoptosis. Application of the store-operated channel (SOC)-inhibitors SK F96365 and 2-APB downmodulated APP-triggered potentiation of cytosolic Ca2+ levels and apoptosis after treatment with thapsigargin. Our data demonstrate that APP-mediated regulation of ER Ca2+ homeostasis significantly modulates Ca2+ store depletion-induced cell death in a SOC- and CHOP-dependent manner, but independent of the UPR.
Purpose of the study: There is a clinical need for antiretroviral therapy (ART) regimens that simplify dosing and make adherence easier for specific patient groups such as former intravenous drug users (IVDU) receiving opiate substitution. Availability of tenofovir DF (TDF) and other once-daily (OD) agents could offer a viable OD regimen. The 3OD study was designed to evaluate the use of OD HAART in IVDU patients.
Methods: 3OD was a single-arm, multicentre, 48-weeks trial to assess efficacy, tolerability and adherence to a OD TDF-containing HAART regimen in former IVDU patients receiving opiate substitution. Of 67 patients enrolled, 27 were antiretroviral treatment naïve, 10 were virologically suppressed (<400 copies/mL), and 30 were re-starting HAART without prior virological failure. Opiate substitution was adjusted according to subject symptoms of opiate overdosing or withdrawal. Various methods were used to assess adherence: besides pill count, patients were asked to fill in a MASRI (Medication Adherence Self-Report Inventory) questionnaire and an electronic log pad diary. Calculation of adherence by pill count assumed that unreturned pills had been taken by the subjects.
Summary of results: Overall, 55% (n = 37, ITT, M = F) of patients had viral load <400 copies/mL at week 48. Using an ITT, M = E analysis, 90% (37/41) of patients reached undetectable VL (<400 copies/mL), 56% (23/41 patients) had plasma HIV-1 RNA concentrations <50 copies/mL at week 48. Only 30 patients (45%) completed the full study and the follow-up period. In 51% of patients, TDF adherence was >100% using pill count. MASRI showed adherence rates of 80–100% in 83–85% of patients; however, 15 patients never entered any data. Diary data were entered by 57 patients; diary data were entered for fewer days than patients received treatment (mean difference 113 days, calculated from treatment start and stop dates).
Conclusion: TDF in combination with other OD antiretrovirals in former IVDU patients showed comparable efficacy to that seen in the average HIV-1 infected population. However, measurement of adherence to self-administered HAART via pill count, MASRI or diary may be misleading in this population.
It has been recognized that molecular classifications will form the basis for neuropathological diagnostic work in the future. Consequently, in order to reach a diagnosis of Alzheimer's disease (AD), the presence of hyperphosphorylated tau (HP-tau) and beta-amyloid protein in brain tissue must be unequivocal. In addition, the stepwise progression of pathology needs to be assessed. This paper deals exclusively with the regional assessment of AD-related HP-tau pathology. The objective was to provide straightforward instructions to aid in the assessment of AD-related immunohistochemically (IHC) detected HP-tau pathology and to test the concordance of assessments made by 25 independent evaluators. The assessment of progression in 7-µm-thick sections was based on assessment of IHC labeled HP-tau immunoreactive neuropil threads (NTs). Our results indicate that good agreement can be reached when the lesions are substantial, i.e., the lesions have reached isocortical structures (stage V–VI absolute agreement 91%), whereas when only mild subtle lesions were present the agreement was poorer (I–II absolute agreement 50%). Thus, in a research setting when the extent of lesions is mild, it is strongly recommended that the assessment of lesions should be carried out by at least two independent observers.
Background: In Germany, 17% of 59,000 persons living with HIV/AIDS are female. Accordingly, the research focus in clinical studies as well as in cohort analyses has been almost exclusively on HIV-positive men. As a consequence, there is an urgent need to characterize and evaluate the outcome of HAART in HIV-positive women and to identify special requirements of this particular patient population.
Methods: Cross-sectional multicentre (n = 31 centres) evaluation to observe characteristics of 1,557 HIV-positive women receiving medical care in Germany between June 2007 and March 2008. Data acquisition was performed using standardized questionnaires.
Summary of results: Of 1,557 HIV-positive women studied, 1,191 (77%) received HAART. Mean age was 40 years and average time of known HIV-infection was 9 years. Risk of HIV transmission was: 40% heterosexual intercourse in Germany, 36% heterosexual intercourse in a high prevalence country; 17% IDU; 7% other reasons for transmission. 46% of the women had a migration background. Mean time on antiretroviral treatment was 7 years. 53% of the female participants had been treated with >2 HAART-regimens. 47% of the study subjects received a PI-based regimen, 33% a NNRTI-based regimen; 20% were on other combinations. The most commonly used PI and NNRTI were lopinavir/r and nevirapine, respectively. Only 48% of all women under HAART achieved a viral load <40 copies/ml. There was a significant difference between the PI-treated group with 44% patients <40 copies/ml and the NNRTI-treated group with 56% <40 copies/ml (p = 0.003).
Conclusion: We found that HIV-positive women depicted an inferior virological response to HAART compared to those previously published in German cohort analyses dominated by men (response rates >75%). Possible differences in adherence or drug resistance may have impacted these results and are currently being evaluated in ongoing sub-analyses. Of note, the lack of a study arm with male patients is a limitation of this investigation. However, this is partly off-set by the fact that there are good comparative data in the male population found in other cohorts. We conclude that our results are in discordance to the popular assumption that there are no gender specific differences in virological treatment outcome of HAART.
Background This study was carried out to compare the HRQoL of patients in general practice with differing chronic diseases with the HRQoL of patients without chronic conditions, to evaluate the HRQoL of general practice patients in Germany compared with the HRQoL of the general population, and to explore the influence of different chronic diseases on patients HRQoL, independently of the effects of multiple confounding variables. Methods A cross-sectional questionnaire survey including the SF-36, the EQ-5D and demographic questions was conducted in 20 general practices in Germany. 1009 consecutive patients aged 15–89 participated. The SF-36 scale scores of general practice patients with differing chronic diseases were compared with those of patients without chronic conditions. Differences in the SF-36 scale/summary scores and proportions in the EQ-5D dimensions between patients and the general population were analyzed. Independent effects of chronic conditions and demographic variables on the HRQoL were analyzed using multivariable linear regression and polynomial regression models. Results The HRQoL for general practice patients with differing chronic diseases tended to show more physical than mental health impairments compared with the reference group of patients without. Patients in general practice in Germany had considerably lower SF-36 scores than the general population (P < 0.001 for all) and showed significantly higher proportions of problems in all EQ-5D dimensions except for the self-care dimension (P < 0.001 for all). The mean EQ VAS for general practice patients was lower than that for the general population (69.2 versus 77.4, P < 0.001). The HRQoL for general practice patients in Germany seemed to be more strongly affected by diseases like depression, back pain, OA of the knee, and cancer than by hypertension and diabetes. Conclusion General practice patients with differing chronic diseases in Germany had impaired quality of life, especially in terms of physical health. The independent impacts on the HRQoL were different depending on the type of chronic disease. Findings from this study might help health professionals to concern more influential diseases in primary care from the patient´s perspective.
Meeting Abstract : Deutsche Gesellschaft für Chirurgie. 125. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 22.-25.04.2008 Einleitung: Über 4 Millionen Menschen leben in Deutschland schätzungsweise mit chronischen Wunden. Aufgrund der demographischen Entwicklung unserer Gesellschaft ist mit einem weiteren Anstieg der zu nicht, oder nur zögerlich heilenden Wunden führenden Erkrankungen diabetisches Fußsyndrom, chronisch venöse Insuffizienz und pAVK auszugehen. Dennoch ist die moderne hydroaktive Wundbehandlung in Deutschland nicht flächendeckend etabliert. Gründe hierfür liegen unter anderem in dem unüberschaubaren Produktsortiment, der unzureichenden Vergütung vor allem im ambulanten Versorgungssektor und in der mangelhaften ärztlichen Ausbildung in Bezug auf Wundtherapie. Ein standardisiertes Wundbehandlungsschema erleichtert die stadiengerechte Anwendung moderner Wundauflagen und dient als nachvollziehbare Entscheidungsgrundlage in der Auswahl der erforderlichen Wundprodukte. Material und Methoden: Anhand eines Bogens werden vier Kriterien (Wundstadium, Wundexsudation, Wundtiefe und Wundinfektion) zur Beurteilung einer Wunde erfasst. Die fotographische Abbildung der verschiedenen Wundstadien erlaubt eine sichere visuelle Zuordnung durch den Therapeuten. Nach Analyse dieser S.E.T.I. Kriterien ergibt sich eine eindeutige stadiengerechte Produktzuordnung, die auch dem weniger geübten eine sichere Anwendung der verschiedenen Produktgruppen ermöglicht. Ergebnisse: Dieser Behandlungsstandard wurde zwischenzeitlich an 3 Kliniken der Maximalversorgung und in einem integrierten Versorgungsmodell zum diabetischen Fußsyndrom etabliert und stellt einen Bestandteil für ein weiteres IV Modell zur pAVK dar. Neben ökonomischen Vorteilen (reduzierte Lagerhaltungskosten, Straffung des Produktsortiments, günstigere Bezugskonditionen) lässt sich eine Verbesserung in der Behandlungsqualität, eine verkürzte stationäre Behandlungsdauer sowie eine vereinfachte Umsetzung einer sektorenübergreifenden Wundversorgung erzielen. Schlussfolgerung: Die Anwendung eines Therapiestandards für die stadiengerechte Behandlung chronischer Wunden ermöglicht eine Anwenderunabhängige gleich bleibend hohe Qualität sowie eine wesentlich vereinfachte Orientierung in dem Produktsortiment. Hierdurch wird weiterhin ein Beitrag zur Schnittstellenoptimierung zwischen dem stationären und ambulanten Versorgungssektor bei chronischen Wunden geleistet. Ein verbindlicher interdisziplinärer und interprofessioneller Wundbehandlungsstandard stellt eine unverzichtbare Qualitätssicherungsmaßnahme in der Wundbehandlung dar.
Infliximab is a monoclonal antibody directed against TNF-alpha. It has been approved for use in rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriatic arthritis and plaque-type psoriasis. In case reports, positive effects on pustular variants of psoriasis have also been reported. However, paradoxically, manifestation of pustular psoriasis and plaque-type psoriasis has been reported in patients treated with TNF antagonists including infliximab for other indications. Here, we report on 5 patients with chronic plaque-type psoriasis who developed palmoplantar pustulosis during or after discontinuation of infliximab therapy. In two of the five cases, manifestation of palmoplantar pustulosis was not accompanied by worsening of plaque-type psoriasis. Possibly, site-specific factors or a differential contribution of immunological processes modulated by TNF inhibitors to palmoplantar pustulosis and plaque-type psoriasis may have played a role.
Background Brain-computer interface methodology based on self-regulation of slow-cortical potentials (SCPs) of the EEG (electroencephalogram) was used to assess conditional associative learning in one severely paralyzed, late-stage ALS patient. After having been taught arbitrary stimulus relations, he was evaluated for formation of equivalence classes among the trained stimuli. Methods A monitor presented visual information in two targets. The method of teaching was matching to sample. Three types of stimuli were presented: signs (A), colored disks (B), and geometrical shapes (C). The sample was one type, and the choice was between two stimuli from another type. The patient used his SCP to steer a cursor to one of the targets. A smiley was presented as a reward when he hit the correct target. The patient was taught A-B and B-C (sample – comparison) matching with three stimuli of each type. Tests for stimulus equivalence involved the untaught B-A, C-B, A-C, and C-A relations. An additional test was discrimination between all three stimuli of one equivalence class presented together versus three unrelated stimuli. The patient also had sessions with identity matching using the same stimuli. Results The patient showed high accuracy, close to 100%, on identity matching and could therefore discriminate the stimuli and control the cursor correctly. Acquisition of A-B matching took 11 sessions (of 70 trials each) and had to be broken into simpler units before he could learn it. Acquisition of B-C matching took two sessions. The patient passed all equivalence class tests at 90% or higher. Conclusion The patient may have had a deficit in acquisition of the first conditional association of signs and colored disks. In contrast, the patient showed clear evidence that A-B and B-C training had resulted in formation of equivalence classes. The brain-computer interface technology combined with the matching to sample method is a useful way to assess various cognitive abilities of severely paralyzed patients, who are without reliable motor control.
Bei Investigator Initiated Trials (IITs) werden alternative risikoadaptierte Monitoring-Strategien in Abhängigkeit vom individuellen Studiendesign und dem Risikoprofil diskutiert, um bei oft restriktiven Ressourcen eine den gesetzlichen Vorgaben genügende Qualität der Studiendurchführung und der Daten zu gewährleisten. Aufgrund einer Literaturanalyse sollten in der vorliegenden Arbeit Untersuchungen ausgewertet werden, in denen quantitative Aussagen zu Datenqualität und Prüfplan-Compliance in klinischen Prüfungen gemacht wurden. Bei der Interpretation der Ergebnisse sollten die implementierten Qualitätssicherungsmaßnahmen berücksichtigt werden. Aufgrund einer systematischen Recherche in MEDLINE konnten 21 Publikationen identifiziert werden, bei denen die Daten- und Prozessqualität in klinischen Prüfungen untersucht, die Qualität durch Überprüfungen mit Source Data Verification vor Ort oder Überprüfung übermittelter Quelldaten in der Studienzentrale ermittelt wurde und quantitative Informationen zu den Bereichen Datenqualität, Protokoll-Compliance oder Defizite bei Einwilligungserklärungen vorlagen. Die Mehrzahl der Untersuchungen ist drei Organisationen zuzuordnen: European Organization für Research and Treatment of Cancer (EORTC) (n=7), National Cancer Institute (NCI) (n=7) und Untersuchungen der Trans-Tasman Radiation Oncology Group (TROG) (n=4). Darüber hinaus wurden drei Untersuchungen weiterer Studiengruppen identifiziert. Die Untersuchungen wurden im Zeitraum von 1981 bis 2003 publiziert. Überwiegend wurden in der Literatur onkologische Studien betrachtet (n=19), wobei die Radiotherapie im Vordergrund stand (n=8). Für die EORTC-Studien wurde in der Regel eine gute Datenqualität berichtet (80-90% korrekte Daten). Punktuelle Probleme wurden im Hinblick auf die Protokoll-Compliance und das Berichten von Nebenwirkungen/schwerwiegenden unerwünschten Ereignissen festgestellt. Eine gute Qualität wurde ebenfalls bzgl. des korrekten Einschlusses von Patienten beobachtet. Durch das NCI wurde ein standardisiertes Audit-System eingeführt und innerhalb von kooperativen Studiengruppen implementiert. Im Rahmen dieser Audits wurden verschiedene Kriterien überprüft und eine überwiegend gute Datenqualität und Protokoll-Compliance festgestellt. Mängel wurden in ca. 5% der Fälle im Hinblick auf die Einwilligungserklärung, die korrekte Anwendung der Einschlusskriterien, Protokollverletzungen, bei der Ermittlung des Zielkriteriums, der Erfassung der Toxizität, der adäquaten Datenlieferung und bei der Datenverifikation beobachtet. In einzelnen Untersuchungen ergaben sich Probleme mit der Behandlungscompliance (10-20%), bei Protokollabweichungen im Hinblick auf die Arzneimitteldosis (10%) und bei der Drug Accountability (15%). Von der TROG wurde ein Qualitätssicherungsprozess implementiert, der auf zentralem Monitoring von kopierten Quelldaten basiert. Durch den Qualitätssicherungsansatz der TROG konnten schwerwiegende Probleme mit der Protokoll-Compliance unter 10% gesenkt werden, ebenso konnte eine gute Datenqualität mit einer Fehlerrate unter 5% erreicht werden. Die korrekte Handhabung von Ein- und Ausschlusskriterien stellte in Einzelfällen ein Problem dar. Zusammenfassend kann festgestellt werden, dass die in dem Review erfassten Studiengruppen von einer guten Datenqualität und einer guten bis moderaten Protokoll-Compliance berichten. Diese basiert nach Aussage der Autoren im wesentlichen auf etablierten Qualitätssicherungs-Prozeduren, wobei das durchgeführte Audit ebenfalls einen potentiellen Einflussfaktor darstellt. Geringe Probleme wurden in der Regel im Hinblick auf die Einwilligungserklärung, die korrekte Handhabung der Ein- und Ausschlusskriterien und die Datenqualität beobachtet. In einzelnen Studien gab es jedoch Probleme mit der Protokoll-Compliance. Insgesamt hängen Anzahl und Art der Mängel von dem Studientyp, dem Qualitätsmanagement und der Organisation der Studiengruppe ab. Wissenschaftsbetrug wurde nur in sehr wenigen Fällen durch die Audits festgestellt. Die vorgelegten Informationen beziehen sich nahezu ausschließlich auf etablierte Studiengruppen; bezüglich Datenqualität und Protokoll-Compliance außerhalb der Studiengruppen liegen kaum Informationen in der Literatur vor. Bei der Bewertung der Ergebnisse sollte berücksichtigt werden, dass es sich zum Teil um Eigenauswertungen der Studiengruppen und nicht um unabhängige externe Prüfungen (z.B. externe Audits) handelt. Inwieweit die Ergebnisse einer konsequenten Überprüfung nach derzeitigen Good Clinical Practice (GCP) – Regeln standhalten würden, kann aus der Analyse nicht beantwortet werden. Aus der vorliegenden Literaturanalyse ergeben sich Konsequenzen für die Planung einer prospektiven kontrollierten Studie zum Vergleich unterschiedlicher Monitoring-Strategien. Wesentlicher Einflussfaktor für die Datenqualität und Protokollcompliance in einer klinischen Studie ist das Qualitätsmanagement. Dieses Qualitätsmanagement umfasst neben Monitoring zahlreiche andere Maßnahmen. Um zu einer Bewertung von Monitoringstrategien kommen zu können, müssen daher alle Qualitätssicherungsmaßnahmen im Rahmen einer Studie berücksichtigt werden. Für den Vergleich unterschiedlicher Monitoringstrategien sind geeignete Zielparameter zu definieren (z.B. schwerwiegende Defizite bzgl. Ein- und Ausschlusskriterien, Sicherheit). Die vorliegende Analyse ergibt, dass bei gutem Qualitätsmanagement ohne umfassendes vor Ort Monitoring schwerwiegende Fehler nur mit relativ niedriger Häufigkeit festgestellt wurden. Unterschiede zwischen Monitoringstrategien könnten, gegeben ein funktionierendes Qualitätsmanagementssystem, sich als quantitativ gering erweisen. Testet man auf Äquivalenz von Monitoringstrategien, sind nur niedrige Differenzen zu akzeptieren, was wiederum eine Auswirkung auf die Fallzahlplanung hat. Weiterhin muss berücksichtigt werden, dass zur Feststellung der Auswirkung unterschiedlicher Monitoringstrategien auf die Sicherheit der Patienten und die Validität der Daten im Rahmen einer kontrollierten Untersuchung ein unabhängiges Audit notwendig ist. Dabei ist zu berücksichtigen, dass ein Audit bereits einen möglichen Einflussfaktor für die Datenqualität und Protokoll-Compliance darstellen kann, und damit eine Bewertung des Nutzens einer Monitoringstrategie erschwert werden könnte. Schlüsselwörter: systematisches Review, Datenqualität, Protokoll-Compliance, klinische Studie
Poster presentation: Purpose of the study The aim of the Rainbow Cohort is to assess the tolerability and efficacy of initiating treatment with, or switching treatment to the saquinavir (SQV) 500 mg film-coated tablet formulation. We present the final 48-week subgroup analysis of PI-experienced, but SQV-naïve patients. ...
Poster presentation: Purpose of the study The aim of the Rainbow Cohort is to assess the tolerability and efficacy of initiating treatment with, or switching treatment to saquinavir (SQV) 500 mg film-coated tablet formulation. We present the final 48-week subgroup analysis of antiretroviral therapy (ART)-naïve patients. ...
Hintergrund: Für die Forschung mit Routinedaten sind Kenntnisse zum Entstehungsprozess sowie zur Validität der Daten Voraussetzung. Ziel der Studie war es, die valide Erfassung forschungsrelevanter Informationen in Arzneimittelroutinedaten zwischen Betäubungsmittel (BtM)-Rezepten und Muster-16-Rezepten (für sonstige Arzneimittel) zu vergleichen.
Methodik: Grundlage waren Routinedaten der Gmünder ErsatzKasse (GEK) aus dem Jahr 2006. Aus den 7,2 Mio. Rezepten wurde eine einfache Zufallsstichprobe von 600 Muster 16 und 600 BtM-Rezepten gezogen. Die eingescannten Originalbelege wurden gesichtet und mit den in Routinedaten befindlichen Informationen verglichen. Die Angaben auf dem Rezept dienten als Goldstandard.
Ergebnisse: Insgesamt ist auf BtM-Rezepten sowohl das Verordnungsdatum (68,1% vs. 92,5%; p<0,0001) wie auch das Abgabedatum (61,8% vs. 85,5%; p<0,0001) schlechter erfasst als auf Muster-16-Rezepten. Auffällig sind die großen Unterschiede zwischen den Apothekenrechenzentren. Die Verrechnungsstelle der Süddeutschen Apotheken GmbH (VSA) als größtes Apothekenrechenzentrum lieferte, im Vergleich zu allen anderen Apothekenrechenzentren, beim Verordnungsdatum (56,1% vs. 73,3%; p<0,0001) wie auch beim Abgabedatum (41,2% vs. 70,8%; p<0,0001) von BtM-Rezepten auffällig seltener korrekte Ergebnisse. Fehler beim Abgabedatum waren bei der VSA assoziiert mit den in den Routinedaten verfügbaren Variablen Art des Rezeptes (Betäubungsmittelrezept vs. Muster 16; Odds Ratio [OR]: 3,12; 95% Konfidenzintervall [KI]: 1,85–5,27), Abgabe laut Routinedaten am Verordnungstag (Ja vs. Nein; OR: 9,33; 95% KI: 1,78–48,87) sowie Verordnung laut Routinedaten am 5., 15. oder 25. (Ja vs. Nein; OR: 6,70; 95% KI: 2,85–15,76).
Schlussfolgerung: Es besteht für hiesige Routinedaten ein erheblicher Mangel an methodisch fundierten Analysen bzw. Validierungsstudien, insbesondere auch zur Güte von Diagnosen.
Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre “Sonderforschungsbereich” 587, “Immune reactions of the lung in infection and allergy” (Hannover Medical School). The aim of these meetings is an intense scientific exchange between researchers and clinicians coming from academic or industrial background. Over the years the topics within the extensive field of asthma and COPD have ranged from methodological aspects to the influence of infections and environmental factors up to perspectives in the development of new therapeutic strategies.
Owing to higher performance on the Raven’s Progressive Matrices (RPM) than on the Wechsler Intelligence Scales (WIS), it has recently been argued that intelligence is underestimated in autism. This study examined RPM and WIS IQs in 48 individuals with autism, a mixed clinical (n = 28) and a neurotypical (n = 25) control group. Average RPM IQ was higher than WIS IQ only in the autism group, albeit to a much lesser degree than previously reported and only for individuals with WIS IQs <85. Consequently, and given the importance of reliable multidimensional IQ estimates in autism, the WIS are recommended as first choice IQ measure in high functioning individuals. Additional testing with the RPM might be required in the lower end of the spectrum.
Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer. Methods We investigated the expression of HDAC 1, 2 and 3 in 106 renal cell carcinomas and corresponding normal renal tissue by immunohistochemistry on tissue micro arrays and correlated expression data with clinico-pathological parameters including patient survival. Results Almost 60% of renal cell carcinomas expressed the HDAC isoforms 1 and 2. In contrast, HDAC 3 was only detected in 13% of all renal tumours, with particular low expression rates in the clear cell subtype. HDAC 3 was significantly higher expressed in pT1/2 tumours in comparison to pT3/4 tumours. Expression of class I HDAC isoforms correlated with each other and with the proliferative activity of the tumours. We found no prognostic value of the expression of any of the HDAC isoforms in this tumour entity. Conclusion Class I HDAC isoforms 1 and 2 are highly expressed in renal cell cancer, while HDAC 3 shows low, histology dependent expression rates. These unexpected differences in the expression patterns suggests alternative regulatory mechanisms of class I HDACs in renal cell cancer and should be taken into account when trials with isoform selective HDI are being planned. Whether HDAC expression in renal cancers is predictive of responsiveness for HDI will have to be tested in further studies.
Background The EGF receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling networks to suppress a response for low input values and to increase to a pre-defined level for inputs exceeding a certain threshold. Several mechanisms to generate this behaviour have been described theoretically, the underlying assumptions of which, however, have not been experimentally demonstrated for the EGF receptor internalization network. Results Here, we present a mathematical model of receptor sorting into alternative pathways that explains the EGF-concentration dependent response of CIE. The described mechanism involves a saturation effect of the dominant clathrin-dependent endocytosis pathway and implies distinct steady-states into which the system is forced for low vs high EGF stimulations. The model is minimal since no experimentally unjustified reactions or parameter assumptions are imposed. We demonstrate the robustness of the sorting effect for large parameter variations and give an analytic derivation for alternative steady-states that are reached. Further, we describe extensibility of the model to more than two pathways which might play a role in contexts other than receptor internalization. Conclusions Our main result is that a scenario where different endocytosis routes consume the same form of receptor corroborates the observation of a clear-cut, stimulus dependent sorting. This is especially important since a receptor modification discriminating between the pathways has not been found. The model is not restricted to EGF receptor internalization and might account for ultrasensitivity in other cellular contexts.
Introduction To investigate the predictive value of clinical and biological markers for a pathological complete remission after a preoperative dose-dense regimen of doxorubicin and docetaxel, with or without tamoxifen, in primary operable breast cancer. Methods Patients with a histologically confirmed diagnosis of previously untreated, operable, and measurable primary breast cancer (tumour (T), nodes (N) and metastases (M) score: T2-3(>= 3 cm) N0-2 M0) were treated in a prospectively randomised trial with four cycles of dose-dense (bi-weekly) doxorubicin and docetaxel (ddAT) chemotherapy, with or without tamoxifen, prior to surgery. Clinical and pathological parameters (menopausal status, clinical tumour size and nodal status, grade, and clinical response after two cycles) and a panel of biomarkers (oestrogen and progesterone receptors, Ki-67, human epidermal growth factor receptor 2 (HER2), p53, bcl-2, all detected by immunohistochemistry) were correlated with the detection of a pathological complete response (pCR). Results A pCR was observed in 9.7% in 248 patients randomised in the study and in 8.6% in the subset of 196 patients with available tumour tissue. Clinically negative axillary lymph nodes, poor tumour differentiation, negative oestrogen receptor status, negative progesterone receptor status, and loss of bcl-2 were significantly predictive for a pCR in a univariate logistic regression model, whereas in a multivariate analysis only the clinical nodal status and hormonal receptor status provided significantly independent information. Backward stepwise logistic regression revealed a response after two cycles, with hormone receptor status and lymph-node status as significant predictors. Patients with a low percentage of cells stained positive for Ki-67 showed a better response when treated with tamoxifen, whereas patients with a high percentage of Ki-67 positive cells did not have an additional benefit when treated with tamoxifen. Tumours overexpressing HER2 showed a similar response to that in HER2-negative patients when treated without tamoxifen, but when HER2-positive tumours were treated with tamoxifen, no pCR was observed. Conclusion Reliable prediction of a pathological complete response after preoperative chemotherapy is not possible with clinical and biological factors routinely determined before start of treatment. The response after two cycles of chemotherapy is a strong but dependent predictor. The only independent factor in this subset of patients was bcl-2. Trial registration number NCT00543829
The indications for allogeneic stem cell transplantation (SCT) in Acute Myeloid Leukemia (AML) represent a real challenge due to the clinical and genetic heterogeneity of the disorder. Therefore, an optimized indication for SCT in AML first requires the determination of the individual relapse risk based on diverse chromosomal and molecular prognosis-defining aberrations. A broad panel of diagnostic methods is needed to allow such subclassification and prognostic stratification: cytomorphology, cytogenetics, molecular genetics, and immunophenotyping by multiparameter flow cytometry. These methods should not be seen as isolated techniques but as parts of an integral network with hierarchies and interactions. Examples for a poor risk constellation as a clear indication for allogeneic SCT are provided by anomalies of chromosome 7, complex aberrations, or FLT3-length mutations. In contrast, the favorable reciprocal translocations such as the t(15;17)/PML-RARA or t(8;21)/AML1-ETO are not indications for SCT in first remission due to the rather good prognosis after standard therapy. Further, the indication for SCT should include the results of minimal residual disease (MRD) diagnostics by polymerase chain reaction (PCR) or flow cytometry. New aspects for a safe and fast risk stratification as basis for an optimized indication for SCT in AML might be provided by novel technologies such as microarray-based gene expression profiling. Keywords: Acute Myeloid Leukemia (AML), Allogeneic Stem Cell Transplantation (SCT), Indication, Cytogenetics, Polymerase Chain Reaction (PCR)
Seit dem Sommersemester 2006 führt der Fachbereich Medizin der J. W. Goethe – Universität kontinuierlich eine Analyse über den Zusammenhang der Oberstufen- und Abiturprüfungsnoten mit den Studiumserfolgen bei den Frankfurter Medizinstudierenden durch. Den Rahmen hierfür bildet das Projekt Studierendenauswahl zur Identifizierung und Validierung geeigneter Prädiktoren des Studienerfolgs zur universitären Auswahl (60 Prozent der Studiumsplätze in den ZVS-Fächern unterliegen der direkten Vergabekompetenz der Hochschulen). Wir präsentieren in dieser Kommunikation die Ergebnisse einer retrospektiven Datenerhebung bei den Studierenden im klinischen Studienabschnitt, welche Kurse zur Erlangung der Hochschulreife ausgewählt wurden (n=700). Hintergrund für dieses Vorgehen ist die Vermutung, dass zwischen der Kurswahl und dem Studienerfolg ein unmittelbarer Zusammenhang besteht. Die Studienleistungen wurden auf der Basis von fachbereichseigenen Prüfungen (vorklinische und klinische Leistungsnachweise) durch die Ergebnisse in den Staatsexamina identifiziert. Des Weiteren sollte geklärt werden, wie viele Leistungskurskombinationen – bedingt durch die Vorgaben des deutschen Oberstufensystems – vorliegen. Erste Auswertungen geben zu erkennen, dass die Korrelation zwischen den erreichten Punkten der individuellen Schulfächer (Mathematik, Biologie, Chemie, Deutsch und Englisch) und den Ergebnissen im 1.Abschnitt der ärztlichen Prüfung deutlich fachabhängig sind. Das Gleiche gilt für die Leistungskurswahl: Die große Anzahl verschiedener Leistungskurskombinationen (bei 700 Studierenden über 80) zeigt ausgesprochen variable Korrelationen mit den Leistungen im 1. Abschnitt der Ärztlichen Prüfung. Dabei ist die Leistungskurskombination Mathematik + Englisch nach unserer gegenwärtigen Analyse der beste Prädiktor für Erfolg im Medizinstudium. Diese Ergebnisse könnten in naher Zukunft als Basis des universitären Auswahlverfahrens für Medizinstudierende dienen.
Meeting Abstract : Deutsche Gesellschaft für Chirurgie. 125. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 22.-25.04.2008 Einleitung: Die Resektion von Lebermetastasen kolorektaler Karzinome stellt die einzige potentiell kurative Behandlungsoption dar. Wirksame Chemotherapeutika wie Oxaliplatin und Irinotecan sind in den Verdacht geraten durch histologische Veränderungen an der Leber das Resektionsausmass oder das Outcome von vorbehandelten Patienten zu gefährden.Die vorliegende Studie untersucht daher den Grad der Steatohepatitis bei Patienten mit kolorektalen Lebermetastasen in Abhängigkeit von der Chemotherapie. Material und Methoden: In einem Kollektiv von 100 konsekutiven Patienten (08/2002 bis 02/2006) (chemonaiv: n=32, 62,4 +/- 13,3 Jahre; neoadjuvante Chemotherapie: n=39, 62 +/- 10,2 Jahre und adjuvante Chemotherapie: n=29, 61,2 +/- 10,8 Jahre) wurde aus den intraoperativ gewonnenen Leberresektaten retrospektiv der NAFLD-Score nach Kleiner et al. (Hepatology 2005) erhoben. Zur morphologischen Beurteilung wurde die Hämatoxilin-Eosin-Färbung verwendet, während der Fibrosegrad anhand der Ladewig-Färbung und der Siderosegrad mittels der Berliner-Blau-Färbung bestimmt wurden.Anschließend erfolgte eine statische Analyse der Häufigkeit und Relevanz der Steatohepatitis in den einzelnen Gruppen im Hinblick auf Verlauf und Outcome der Leberresektion. Hierbei wurden multivariate Regression, Kruskal-Wallis-Test, chi2-Test oder Mann-Whitney-U-Test (p<0,05) verwendet. Ergebnisse: Im vorliegenden Patientengut zeigten 7 Patienten eine ausgeprägte NASH, während bei 69% der Patienten keinerlei Veränderungen im Sinne einer NASH vorlagen. Die subjektive Gesamtbeurteilung der Pathologen und der errechnete NASH-Score eine Übereinstimmung in 92%. (Cohen´s kappa 0,82; 95%-Konfidenzintervall [0,71-0,93]). Hinsichtlich des NASH-Score (p=0,462) oder seiner Komponenten konnten keine Unterschiede in Abhängigkeit vom Zeitpunkt der Chemotherapie (Chemonaiv/ neoadjuvant/ adjuvant) gefunden werden. Eine Analyse in Abhängigkeit der verwendeten Chemotherapeutika zeigte keine Unterschiede für den Gesamt-Score (p=0,897), jedoch signifikante Unterschiede für einzelne Komponenten: Portale Entzündung (p=0,045) und Vorliegen von Microgranulomen (p<0,001). Auch eine multivariate Analyse konnte weder den Einfluss von Substanz noch Zeitpunkt der Chemotherapie auf die Entwicklung einer NASH (p zwischen 0,35 und 0,92) nachweisen.Die Analyse des perioperativen Verlaufs (Transfusionsbedarf, Radikalität, Komplikationen, Liegedauer, postoperative Leberfunktion, Krankenhausmortalität) ergab keine signifikanten Unterschiede für Patienten mit oder ohne NASH. Schlussfolgerung: Das Vorliegen einer Steatohepatitis in unserem Patientengut war eine seltene Diagnose, die nicht in Zusammenhang mit Zeitpunkt der Chemotherapie oder verwendetem Chemotherapeutikum stand. Selbst das Vorliegen einer NASH scheint keinen relevanten Einfluss auf den perioperativen Verlauf oder das Outcome nach Leberresektion zu haben.
Background Osseointegration is crucial for the long-term success of dental implants and depends on the tissue reaction at the tissue-implant interface. Mechanical properties and biocompatibility make zirconia a suitable material for dental implants, although surface processings are still problematic. The aim of the present study was to compare osteoblast behavior on structured zirconia and titanium surfaces under standardized conditions. Methods The surface characteristics were determined by scanning electron microscopy (SEM). In primary bovine osteoblasts attachment kinetics, proliferation rate and synthesis of bone-associated proteins were tested on different surfaces. Results The results demonstrated that the proliferation rate of cells was significantly higher on zirconia surfaces than on titanium surfaces (p < 0.05; Student's t-test). In contrast, attachment and adhesion strength of the primary cells was significant higher on titanium surfaces (p < 0.05; U test). No significant differences were found in the synthesis of bone-specific proteins. Ultrastructural analysis revealed phenotypic features of osteoblast-like cells on both zirconia and titanium surfaces. Conclusion The study demonstrates distinct effects of the surface composition on osteoblasts in culture. Zirconia improves cell proliferation significantly during the first days of culture, but it does not improve attachment and adhesion strength. Both materials do not differ with respect to protein synthesis or ultrastructural appearance of osteoblasts. Zirconium oxide may therefore be a suitable material for dental implants.
Background Titanium and titanium alloys are widely used for fabrication of dental implants. Since the material composition and the surface topography of a biomaterial play a fundamental role in osseointegration, various chemical and physical surface modifications have been developed to improve osseous healing. Zirconia-based implants were introduced into dental implantology as an altenative to titanium implants. Zirconia seems to be a suitable implant material because of its tooth-like colour, its mechanical properties and its biocompatibility. As the osseointegration of zirconia implants has not been extensively investigated, the aim of this study was to compare the osseous healing of zirconia implants with titanium implants which have a roughened surface but otherwise similar implant geometries. Methods Forty-eight zirconia and titanium implants were introduced into the tibia of 12 minipigs. After 1, 4 or 12 weeks, animals were sacrificed and specimens containing the implants were examined in terms of histological and ultrastructural techniques. Results Histological results showed direct bone contact on the zirconia and titanium surfaces. Bone implant contact as measured by histomorphometry was slightly better on titanium than on zirconia surfaces. However, a statistically significant difference between the two groups was not observed. Conclusion The results demonstrated that zirconia implants with modified surfaces result in an osseointegration which is comparable with that of titanium implants.
Background The successful use of zirconia ceramics in orthopedic surgery led to a demand for dental zirconium-based implant systems. Because of its excellent biomechanical characteristics, biocompatibility, and bright tooth-like color, zirconia (zirconium dioxide, ZrO2) has the potential to become a substitute for titanium as dental implant material. The present study aimed at investigating the osseointegration of zirconia implants with modified ablative surface at an ultrastructural level. Methods A total of 24 zirconia implants with modified ablative surfaces and 24 titanium implants all of similar shape and surface structure were inserted into the tibia of 12 Gottinger minipigs. Block biopsies were harvested 1 week, 4 weeks or 12 weeks (four animals each) after surgery. Scanning electron microscopy (SEM) analysis was performed at the bone implant interface. Results Remarkable bone attachment was already seen after 1 week which increased further to intimate bone contact after 4 weeks, observed on both zirconia and titanium implant surfaces. After 12 weeks, osseointegration without interposition of an interfacial layer was detected. At the ultrastructural level, there was no obvious difference between the osseointegration of zirconia implants with modified ablative surfaces and titanium implants with a similar surface topography. Conclusion The results of this study indicate similar osseointegration of zirconia and titanium implants at the ultrastructural level.
Several regions in human temporal and frontal cortex are known to integrate visual and auditory object features. The processing of audio–visual (AV) associations in these regions has been found to be modulated by object familiarity. The aim of the present study was to explore training-induced plasticity in human cortical AV integration. We used functional magnetic resonance imaging to analyze the neural correlates of AV integration for unfamiliar artificial object sounds and images in naïve subjects (PRE training) and after a behavioral training session in which subjects acquired associations between some of these sounds and images (POST-training). In the PRE-training session, unfamiliar artificial object sounds and images were mainly integrated in right inferior frontal cortex (IFC). The POST-training results showed extended integration-related IFC activations bilaterally, and a recruitment of additional regions in bilateral superior temporal gyrus/sulcus and intraparietal sulcus. Furthermore, training-induced differential response patterns to mismatching compared with matching (i.e., associated) artificial AV stimuli were most pronounced in left IFC. These effects were accompanied by complementary training-induced congruency effects in right posterior middle temporal gyrus and fusiform gyrus. Together, these findings demonstrate that short-term cross-modal association learning was sufficient to induce plastic changes of both AV integration of object stimuli and mechanisms of AV congruency processing.
Background: The hemagglutinin (HA) glycoprotein is the principal target of protective humoral immune responses to influenza virus infections but such antibody responses only provide efficient protection against a narrow spectrum of HA antigenic variants within a given virus subtype. Avian influenza viruses such as H5N1 are currently panzootic and pose a pandemic threat. These viruses are antigenically diverse and protective strategies need to cross protect against diverse viral clades. Furthermore, there are 16 different HA subtypes and no certainty the next pandemic will be caused by an H5 subtype, thus it is important to develop prophylactic and therapeutic interventions that provide heterosubtypic protection. Methods and Findings: Here we describe a panel of 13 monoclonal antibodies (mAbs) recovered from combinatorial display libraries that were constructed from human IgM+ memory B cells of recent (seasonal) influenza vaccinees. The mAbs have broad heterosubtypic neutralizing activity against antigenically diverse H1, H2, H5, H6, H8 and H9 influenza subtypes. Restriction to variable heavy chain gene IGHV1-69 in the high affinity mAb panel was associated with binding to a conserved hydrophobic pocket in the stem domain of HA. The most potent antibody (CR6261) was protective in mice when given before and after lethal H5N1 or H1N1 challenge. Conclusions: The human monoclonal CR6261 described in this study could be developed for use as a broad spectrum agent for prophylaxis or treatment of human or avian influenza infections without prior strain characterization. Moreover, the CR6261 epitope could be applied in targeted vaccine strategies or in the design of novel antivirals. Finally our approach of screening the IgM+ memory repertoire could be applied to identify conserved and functionally relevant targets on other rapidly evolving pathogens.
Die Evaluation der studentischen Lehre - Basis für eine leistungsorientierte Mittelvergabe (LOM)?
(2008)
Die Evaluation der medizinischen Ausbildung wird am Fachbereich Medizin der J.W. Goethe – Universität Frankfurt seit 1998 systematisch durchgeführt. Damit ist diese Implementierung deutlich vor den bindenden Bestimmungen der Ärztlichen Approbationsordnung (in Kraft getreten am 01.10.2003) installiert worden. Die Evaluation der studentischen Lehre beinhaltet die Evaluierung sämtlicher Pflichtveranstaltungen (Kurse, Seminare, Praktika) durch einen standardisierten Fragebogen, der am Ende der Lehrpflichtveranstaltung (in jedem Semester) ausgeteilt und nach dem Ausfüllen durch die Studierenden wieder eingesammelt wird.
In dieser Kommunikation belegen wir anhand ausgewählter Beispiele (vom Wintersemester 2003/2004 bis zum Wintersemester 2005/2006), dass die anderen Orts oft vorgetragenen negativen studentischen Bewertungen der vorklinischen Fächer an der J.W. Goethe – Universität nicht zutreffen (Bsp.:Kursus Anatomie I, Makroskopischer Teil, WS 2005/2006: M=1,8, SD=0,86). Die Bewertung der didaktischen Qualität („Lehrstoff wurde gut verständlich präsentiert“) ist bei den meisten vorklinischen Pflichtveranstaltungen zufriedenstellend (Bsp.: Kursus Anatomie I, Makroskopischer Teil, WS 2005/2006: M=2,06, SD=0,94). Aus diesen Ergebnissen schließen wir auf eine positive Rückwirkung des curricularen und didaktischen Umbaus des Medizinstudiums an der Goethe – Universität.
Die Veröffentlichung der Ergebnisse der studentischen Evaluation („Zusammenfassende Beurteilung“) muss dem Umstand Rechnung tragen, dass praxisferne Fächer vielen Studierenden nur schwer zu vermitteln sind. Deswegen wird auf ein Ranking verzichtet. Nach diesen Ergebnissen wird ein Teil der Mittel leistungsorientiert vergeben (im jährlichen Zyklus). Diese leistungsorientierte Mittelvergabe (LOM) (davon 45 Prozent nach der studentischen Evaluation) beträgt 4 Prozent des jeweiligen Grundetats für Forschung und Lehre (Landeszuführung). Eine positive Lehrevaluation kann für eine Klinik/ein Institut einen wesentlich größeren Betrag bedeuten. Das Verfahren ist am Fachbereich akzeptiert.
Platelets play an essential role in wound healing by forming thrombi that plug holes in the walls of damaged blood vessels. To achieve this, platelets express a diverse array of cell surface receptors and signaling proteins that induce rapid platelet activation. In this study we show that two platelet glycoprotein receptors that signal via an immunoreceptor tyrosine-based activation motif (ITAM) or an ITAM-like domain, namely the collagen receptor complex glycoprotein VI (GPVI)-FcR γ-chain and the C-type lectin-like receptor 2 (CLEC-2), respectively, support constitutive (i.e. agonist-independent) signaling in a cell line model using a nuclear factor of activated T-cells (NFAT) transcriptional reporter assay that can detect low level activation of phospholipase Cγ (PLCγ). Constitutive and agonist signaling by both receptors is dependent on Src and Syk family kinases, and is inhibited by G6b-B, a platelet immunoglobulin receptor that has two immunoreceptor tyrosine-based inhibitory motifs in its cytosolic tail. Mutation of the conserved tyrosines in the two immunoreceptor tyrosine-based inhibitory motifs prevents the inhibitory action of G6b-B. Interestingly, the inhibitory activity of G6b-B is independent of the Src homology 2 (SH2)-domain containing tyrosine phosphatases, SHP1 and SHP2, and the inositol 5′-phosphatase, SHIP. Constitutive signaling via Src and Syk tyrosine kinases is observed in platelets and is associated with tyrosine phosphorylation of GPVI-FcR γ-chain and CLEC-2. We speculate that inhibition of constitutive signaling through Src and Syk tyrosine kinases by G6b-B may help to prevent unwanted platelet activation.
Background:The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCgamma2 in platelets downstream of GPVI/FcRgamma and the C-type lectin receptor CLEC-2. SLP-76 is constitutively associated with the adapter Gads in platelets, which also binds to tyrosine phosphorylated LAT, thereby providing a potential pathway of regulation of SLP-76. Objective:In the present study, we have compared the role of Gads alongside that of LAT following activation of the major platelet glycoprotein receptors using mice deficient in the two adapter proteins. Results:Gads was found to be required for the efficient onset of aggregation and secretion in response to submaximal stimulation of GPVI and CLEC-2, but to be dispensable for activation following stronger stimulation of the two receptors. Gads was also dispensable for spreading induced through integrin alphaIIbbeta3 or the GPIb–IX–V complex. Further, Gads plays a negligible role in aggregate formation on collagen at an arteriolar rate of shear. In stark contrast, platelets deficient in the adapter LAT exhibit a marked decrease in aggregation and secretion following activation of GPVI and CLEC-2, and are unable to form stable aggregates on collagen at arteriolar shear. Conclusions:The results demonstrate that Gads plays a key role in linking the adapter LAT to SLP-76 in response to weak activation of GPVI and CLEC-2 whereas LAT is required for full activation over a wider range of agonist concentrations. These results reveal the presence of a Gads-independent pathway of platelet activation downstream of LAT. Keywords: CLEC-2, Gads, GPVI, LAT, platelet, signalosome, SLP-76
Histone deacetylase (HDAC) inhibitors represent a promising class of antineoplastic agents which affect tumour growth, differentiation and invasion. The effects of the HDAC inhibitor valproic acid (VPA) were tested in vitro and in vivo on pre-clinical renal cell carcinoma (RCC) models. Caki-1, KTC-26 or A498 cells were treated with various concentrations of VPA during in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays and to evaluate cell cycle manipulation. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. The anti-tumoural potential of VPA combined with low-dosed interferon-α (IFN-α) was also investigated. VPA significantly and dose-dependently up-regulated histones H3 and H4 acetylation and caused growth arrest in RCC cells. VPA altered cell cycle regulating proteins, in particular CDK2, cyclin B, cyclin D3, p21 and Rb. In vivo, VPA significantly inhibited the growth of Caki-1 in subcutaneous xenografts, accompanied by a strong accumulation of p21 and bax in tissue specimens of VPA-treated animals. VPA–IFN-α combination markedly enhanced the effects of VPA monotherapy on RCC proliferation in vitro, but did not further enhance the anti-tumoural potential of VPA in vivo. VPA was found to have profound effects on RCC cell growth, lending support to the initiation of clinical testing of VPA for treating advanced RCC.
The purpose of this phase III clinical trial was to compare two different extracellular contrast agents, 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine, for magnetic resonance imaging (MRI) in patients with known or suspected focal renal lesions. Using a multicenter, single-blind, interindividual, randomized study design, both contrast agents were compared in a total of 471 patients regarding their diagnostic accuracy, sensitivity, and specificity to correctly classify focal lesions of the kidney. To test for noninferiority the diagnostic accuracy rates for both contrast agents were compared with CT results based on a blinded reading. The average diagnostic accuracy across the three blinded readers (‘average reader’) was 83.7% for gadobutrol and 87.3% for gadopentate dimeglumine. The increase in accuracy from precontrast to combined precontrast and postcontrast MRI was 8.0% for gadobutrol and 6.9% for gadopentate dimeglumine. Sensitivity of the average reader was 85.2% for gadobutrol and 88.7% for gadopentate dimeglumine. Specificity of the average reader was 82.1% for gadobutrol and 86.1% for gadopentate dimeglumine. In conclusion, this study documents evidence for the noninferiority of a single i.v. bolus injection of 1.0 M gadobutrol compared with 0.5 M gadopentate dimeglumine in the diagnostic assessment of renal lesions with CE-MRI.
Prognostische Bedeutung der R1 Resektion : verbessertes Überleben in der Ära elektiver Chemotherapie
(2008)
Einleitung: Die Resektion kolorektaler Lebermetastasen ist der alleinigen Chemotherapie überlegen und erfolgt unter kurativer Zielsetzung. Multimodale Therapiekonzepte erlauben zunehmend primär irresektable Metastasen sekundär zu resezieren. Bei einem Teil der Patienten wird das Ziel der Tumorfreiheit nicht erreicht. Anhand einer retrospektiven Analyse wurde der Anteil der nicht kurativ resezierten Patienten nach primärer und sekundärer Resektion und ihr Überleben bestimmt. Material und Methoden: Bei 152 Patienten wurden zwischen 1/02 – 7/07 insgesamt 174 Leberresektionen aufgrund kolorektaler Metastasen durchgeführt. Dieses Kollektiv wurde anhand des R-Status der Leberresektion in eine kurativ- (Gruppe I) und in eine nicht kurativ resezierte Gruppe (Gruppe II) unterteilt. Die Auswertung erfolgte retrospektiv nach Überleben, Metastasenausdehnung, neoadjuvanter Chemotherapie und primärem Tumorstadium. Ergebnisse: 174 Leberresektionen schlossen 44 Re-Resektion und 6 zweizeitige Resektionen ein. Bei 61 Patienten erfolgte eine neoadjuvante Chemotherapie vor der Leberresektion. Die demographischen Daten beider Gruppen zeigten keinen signifikanten Unterschied (Gr. I: Männer: 60%, Alter: 63+/-1; Gr. II: Männer: 65%, Alter: 57+/-2,4). Die Anzahl der resezierten Metastasen war in Gruppe II signifikant höher (Gr. I: 1,5+/-0,1; Gr. II: 3,5+/-0,7, p<0,01), während die lokale Primärtumor-Ausdehnung gemessen am T-Stadium (Gr. I: 2,8 +/- 0,1, Gr. II: 2,8 +/- 0,13, n.s.) keinen Unterschied zeigte. Der Anteil der nicht kurativ resezierten Patienten war nach primärer und sekundärer Resektion gleich (17% vs. 21%, n.s.). Das Gesamtüberleben (4-Jahre, Kaplan-Meier) (Gr. I: 61%, Gr. II: 29%, p<0,05) und das mediane Überleben (Gr. I: 4,4, Gr. II: 2,4 [Jahre], p<0,05) wiesen einen signifikanten Unterschied auf. Schlussfolgerung: Der R-Status nach Resektion kolorektaler Lebermetastasen ist weiterhin ein entscheidender prognostischer Faktor. R-1 resezierte Patienten erreichen jedoch mit 2,4 Jahren ein besseres medianes Überleben als vergleichbare historische Kollektive. Sekundäre Resektionen nach neoadjuvanter Therapie weisen eine vergleichbar hohe Rate an R1 Resektionen auf wie bei primären Resektionen.
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma
(2008)
The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti-neoplastic effects in vitro may not be reached in tumour patients. In this study, we tested in vitro and in vivo effects of two VPA-derivatives (ACS2, ACS33) on pre-clinical prostate cancer models. PC3 and DU-145 prostate tumour cell lines were treated with various concentrations of ACS2 or ACS33 to perform in vitro cell proliferation 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays and to evaluate tumour cell adhesion to endothelial cell monolayers. Analysis of acetylated histones H3 and H4 protein expression was performed by western blotting. In vivo tumour growth was conducted in subcutaneous xenograft mouse models. Tumour sections were assessed by immunohistochemistry for histone H3 acetylation and proliferation. ACS2 and ACS33 significantly up-regulated histone H3 and H4 acetylation in prostate cancer cell lines. In micromolar concentrations both compounds exerted growth arrest in PC3 and DU-145 cells and prevented tumour cell attachment to endothelium. In vivo, ACS33 inhibited the growth of PC3 in subcutaneous xenografts. Immunohistochemistry and western blotting confirmed increased histone H3 acetylation and reduced proliferation. ACS2 and ACS33 represent novel VPA derivatives with superior anti-tumoural activities, compared to the mother compound. This investigation lends support to the clinical testing of ACS2 or ACS33 for the treatment of prostate cancer.
Im Juli 2000 wurde die Arbeitsgruppe Evidenzbasierte Medizin Frankfurt von einer Gruppe Studierender an der Goethe-Universität gegründet, um die Anwendung der klinisch-wissenschaftlichen Medizin und deren Lehre mit Hilfe der Methoden der Evidenzbasierten Medizin zu verbessern. Aus den mittlerweile 21 freiwilligen zunächst studentischen Kursen in Evidenzbasierter Medizin sind deutschlandweit die ersten verpflichtenden Seminare in Evidenzbasierter Medizin entstanden. Aufgrund des Einsatzes neuer Lehrmethoden von Beginn an und der kontinuierlichen Verbesserung des Seminars sind sowohl formative als auch summative Evaluationen sehr gut. Die im Rahmen der Lehrforschung erhobenen Evaluationsdaten konnten hochrangig publiziert werden. ...
Echocardiography is increasingly used in the management of the critically ill patient as a non-invasive diagnostic and monitoring tool. Whilst in few countries specialized national training schemes for intensive care unit (ICU) echocardiography have been developed, specific guidelines for ICU physicians wishing to incorporate echocardiography into their clinical practice are lacking. Further, existing echocardiography accreditation does not reflect the requirements of the ICU practitioner. The WINFOCUS (World Interactive Network Focused On Critical UltraSound) ECHO-ICU Group drew up a document aimed at providing guidance to individual physicians, trainers and the relevant societies of the requirements for the development of skills in echocardiography in the ICU setting. The document is based on recommendations published by the Royal College of Radiologists, British Society of Echocardiography, European Association of Echocardiography and American Society of Echocardiography, together with international input from established practitioners of ICU echocardiography. The recommendations contained in this document are concerned with theoretical basis of ultrasonography, the practical aspects of building an ICU-based echocardiography service as well as the key components of standard adult TTE and TEE studies to be performed on the ICU. Specific issues regarding echocardiography in different ICU clinical scenarios are then described. Obtaining competence in ICU echocardiography may be achieved in different ways – either through completion of an appropriate fellowship/training scheme, or, where not available, via a staged approach designed to train the practitioner to a level at which they can achieve accreditation. Here, peri-resuscitation focused echocardiography represents the entry level – obtainable through established courses followed by mentored practice. Next, a competence-based modular training programme is proposed: theoretical elements delivered through blended-learning and practical elements acquired in parallel through proctored practice. These all linked with existing national/international echocardiography courses. When completed, it is anticipated that the practitioner will have performed the prerequisite number of studies, and achieved the competency to undertake accreditation (leading to Level 2 competence) via a recognized National or European examination and provide the appropriate required evidence of competency (logbook). Thus, even where appropriate fellowships are not available, with support from the relevant echocardiography bodies, training and subsequently accreditation in ICU echocardiography becomes achievable within the existing framework of current critical care and cardiological practice, and is adaptable to each countrie's needs.
Introduction: Despite the fact that people older than 65 years of age have the highest incidence of developing breast cancer, these patients are excluded from clinical trials in most cases. Furthermore, most physicians tend towards therapy regimens without the use of dose-dense, highly active taxane-based treatments because of a lack of data regarding toxicities of these compounds in older patients.
Methods: Pooled side-effect data were analyzed from four prospective, randomized clinical trials in which patients of different age groups (< 60 years, between 60 and 64 years, and > 64 years) with primary breast cancer received taxane-based chemotherapy.
Results: Dose delays, dose reductions, hospitalization, and therapy discontinuation increased with age. Hematologic toxicities and some nonhematologic toxicities were generally more common in older patients. Leucopenia increased from 55.3% in patients aged < 60 years to 65.5% in patients aged > 64 years (P < 0.001), and neutropenia increased from 46.9% to 57.4% (P < 0.001). There was no difference, however, in clinically more relevant febrile neutropenia between the different age groups. Thrombopenia shows a similar age-dependent increase, whereas there is no difference between the age groups concerning anemia. Hot flushes and elevated liver enzymes decreased with increasing age.
Conclusions: The present pooled analysis of a substantial cohort of older primary breast cancer patients demonstrates that taxane-containing (neo)adjuvant chemotherapy is feasible in older patients and that toxicity can be reduced by sequential therapy regimens.
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors. Bid has also been reported to be cleaved by other proteases. Methodology/Principal Findings: To test the hypothesis that Bid is a central mediator of stress-induced apoptosis, we investigated the effects of a small molecule Bid inhibitor on stress-induced apoptosis, and generated HeLa cells deficient for Bid. Stable knockdown of bid lead to a pronounced resistance to Fas/CD95- and TRAIL-induced caspase activation and apoptosis, and significantly increased clonogenic survival. While Bid-deficient cells were equally sensitive to ER stress-induced apoptosis, they showed moderate, but significantly reduced levels of apoptosis, as well as increased clonogenic survival in response to the genotoxic drugs Etoposide, Oxaliplatin, and Doxorubicin. Similar effects were observed using the Bid inhibitor BI6C9. Interestingly, Bid-deficient cells were dramatically protected from apoptosis when subtoxic concentrations of ER stressors, Etoposide or Oxaliplatin were combined with subtoxic TRAIL concentrations. Conclusions/Significance: Our data demonstrate that Bid is central for death receptor-induced cell death and participates in anti-cancer drug-induced apoptosis in human cervical cancer HeLa cells. They also show that the synergistic effects of TRAIL in combination with either ER stressors or genotoxic anti-cancer drugs are nearly exclusively mediated via an increased activation of Bid-induced apoptosis signalling.
Einleitung: Anastomoseninsuffizienzen sind schwerwiegende Komplikationen nach Kolonresektionen. Nur selten sind klinische oder laborchemische Zeichen Vorboten einer Insuffizienz. Material und Methoden: Wir haben unser Patientenkollektiv nach kolorektalen Resektionen retrospektiv untersucht in Hinblick auf einen Anstieg des C-rektiven Proteins (CRP) postoperativ als Zeichen einer Insuffizienz. Hierzu wurde der Unterschied vom präoperativen Messwert zum Messwert am 1. bis 7. postoperativen Tag berechnet. Bei Patienten mit Anastomoseninsuffizienz wurden die Werte nur bis zum Tag der Insuffizienz einbezogen, um einen Anstieg durch eine eventuelle Revision auszuklammern. Ergebnisse: Im Zeitraum von 8/2002 bis 8/2005 wurden bei 342 Patienten eine Kolonresektion durchgeführt. Im einzelnen waren dies 101 (29,5%) Sigmaresektionen, 89 (26,0%) Hemikolektomien rechts, 56 (16,4%) Rektumresektionen, 38 (11,1%) Ileocoecalresektionen, 24 (7,0%) Hemikolektomien links, 22 (6,4%) Segmentresektionen, 12 (3,5%) Kolektomien. Das Alter der Patienten lag bei 61,6 +/- 15,0 Jahren. Es wurden 142 (41,5%) Frauen und 200 (58,5%) Männer operiert, 301 (88%) Patienten elektiv und 41 (12%) als Notfall. Die Inzidenz von symptomatischen und asymptomatischen Anastomosen-insuffizienzen lag im Gesamtkollektiv bei 26/342 (7,6%), sie traten durchschnittlich 8,7 +/- 7,1 (1-27) Tage nach der Operation auf. Eine Analyse der CRP-Werte ergab bei den Patienten die im Verlauf eine Anastomoseninsuffizienz entwickelten signifikant höhere Anstiege von präoperativ bis zum 3. (+10,9 mg/dl versus +16,5 mg/dl, p=0,018), 5. (+4,2 mg/dl versus +13,1 mg/dl, p=0,002), 6. (+3,8 mg/dl versus +14,6 mg/dl, p=0,002), und 7. (+2,8 mg/dl versus +18,3 mg/dl, p<0,001) postoperativen Tag. Die Differenz zum 4. postoperativen Tag zeigte keinen signifikanten Unterschied (+6,5 mg/dl versus +11,2 mg/dl, p=0,3). Die absoluten Messwerte waren nicht signifikant unterschiedlich. Andere Laborparameter wie Leukozyten, Kreatinin, Albumin ergaben keinen Unterschied im Vergleich der beiden Gruppen.Die Untersuchung von Risikofaktoren für eine Anastomoseninsuffizienz konnte keinen signifikanten Unterschied zeigen für: Alter, Geschlecht, ASA, OP-Dauer, Zugang (offen oder laparoskopisch), benigne oder maligne Erkrankung, Kolon- oder Rektumresektion, elektive oder Notfalloperation. Schlussfolgerung: Der Verlauf des CRP ist ein signifikanter Marker für das Auftreten von Anastomoseninsuffizienzen nach kolorektalen Resektionen.
Meeting Abstract : Deutsche Gesellschaft für Chirurgie. 125. Kongress der Deutschen Gesellschaft für Chirurgie. Berlin, 22.-25.04.2008 Einleitung: Konventionelle Ösophagusresektionen gehen auch heute noch mit einer hohe Morbidität und Mortalität einher. Die Ergebnisse einiger Serien minimal-invasiver Ösophagusresektionen sind vielversprechend, aber kontrovers diskutiert. Material und Methoden: Im Rahmen einer Beobachtungsstudie werden seit Mai 2005 minimal-invasive thorakoabdominelle Ösophagektomien mit cervikalem Magenhochzug durchgeführt. Die operativen Parameter und der postoperative Verlauf werden prospektiv erfasst und jetzt retrospektiv ausgewertet. Ergebnisse: Seit Mai 2005 wurden 28 Patienten minimal-invasive ösophagektomiert, 3 transhiatal und 25 thorakoabdominell. Indikation waren Plattenepithelkarzinome bei 14 und distale Adenokarzinome bei 13 Patienten, bei einem Patienten eine langstreckige benigne Stenose. Die Tumorstadien waren UICC-IIa in 7, UICC-2b in 2 und UICC-III in 18 Patienten. 11 Patienten (41%) wurden neoadjuvant vorbehandelt. Die OP-Zeit betrug im Mittel 296 Min. +/- 46 Min., der intraoperative Blutverlust 110 ml +/- 131 ml. Ein abdomineller Operationsabschnitt wurde konvertiert (4%), thorakal war bisher keine Konversion notwendig. R-0 Resektionen wurde in 26/27 Patienten (96%) erzielt, die mittlere Anzahl entfernter Lymphknoten betrug 19. Die 30-Tage –Letalität war 0, die Krankenhausletalität 11%. Die Morbidität betrug 54% und beinhaltet 7 Anastomoseninsuffizienzen, 2 „Ösophago“-tracheale Fisteln, 1 Hiatushernie, 2 Recurrensparesen, 2 Pneumonien und 1 beatmungspflichtiges Delir. Drei Patienten (11%) wurden operativ revidiert (eine Fistel, eine Anastomoseninsuffizienz bei Magenschlauchnekrose, eine Hiatushernie). Schlussfolgerung: Nach Einführung der minimal-invasiven thorakoabdominellen Ösophagektomie werden die exzellenten Ergebnisse anderer minimal-invasiver Serien bisher nicht erreicht, entsprechen aber im Wesentlichen den Ergebnissen der konventionellen Technik. Abzuwarten bleibt, ob die Ergebnisse nach weiterer Abflachung der Lernkurve Verbesserungen aufweisen werden.
Einleitung: Am 16.12.06 wurde im Eurotransplant-Gebiet der MELD-Score (MELD) als Allokationsbasis zur Lebertransplantation (OLT) eingeführt. Ziel ist eine Reduktion der Sterblichkeit auf der Warteliste. Material und Methoden: 100 Patienten wurden in die prospektive Analyse der MELD-Allokation vom 16.12.06 bis 15.09.07 einbezogen. Ergebnisse: Aktuell warten 68 Pat., 28 Pat. wurden transplantiert, 4 Pat. sind auf der Warteliste (WL) verstorben (4%). Der mittlere MELD auf der WL beträgt 17,2 +/- 5,2 (7-28). Bei 12 Pat. liegt eine Standard-exception (SE) (n=10 HCC, n=2 metabolische Erkrankung) mit einem Match-MELD von 25,6 +/-2,06 vor (24-28). Die Todesursachen der vier auf der WL verstorbenen Pat. waren eine akute Varizenblutung (MELD 9), zwei kardiale Versagen (MELD 13, 18) und eine MRSA-Sepsis (MELD 29, NT-Status). Die 28 transplantierten Pat. hatte zum Zeitpunkt der Transplantation einen mittleren MELD von 27,66 +/- 5,1 Punkten (21 bis 40). 20 Pat. wurden aufgrund des Labor-MELD (28,4 +/- 5,3, 24-40) transplantiert, wobei 7 Pat. einen MELD über 30 aufwiesen. Die Wartezeit lag bei 11,55 +/- 5,3 Tagen. 8 Pat. erhielten bei SE bei HCC (MELD 24 +/- 0, 24) ein Organ nach einer Wartezeit von 320 +/- 9,7 Tagen. Aktuell leben 23 der 28 transplantierten Pat. Bei zwei verstorbenen Pat. war die Todesursache ein kardiales Versagen, bei zwei Patienten eine primäre Non-Funktion sowie ein septisches Multiorganversagen. Schlussfolgerung: Während der ersten Monate der MELD Allokation lag die Letalität auf der WL in unserem Zentrum bei 4%. Patienten mit einem mittleren MELD über 27 erhielten Organangebote und konnten nach kurzer Wartezeit transplantiert werden.
Gene trapping is used to introduce insertional mutations into genes of mouse embryonic stem cells (ESCs). It is performed with gene trap vectors that simultaneously mutate and report the expression of the endogenous gene at the site of insertion and provide a DNA tag for rapid identification of the disrupted gene. Gene traps have been employed worldwide to assemble libraries of mouse ESC lines harboring mutations in single genes, which can be used to make mutant mice. However, most of the employed gene trap vectors require gene expression for reporting a gene trap event and therefore genes that are poorly expressed may be under-represented in the existing libraries. To address this problem, we have developed a novel class of gene trap vectors that can induce gene expression at insertion sites, thereby bypassing the problem of intrinsic poor expression. We show here that the insertion of the osteopontin enhancer into several conventional gene trap vectors significantly increases the gene trapping efficiency in high-throughput screens and facilitates the recovery of poorly expressed genes.
Objective: To develop comprehensive recommendations for the treatment of the various clinical manifestations of psoriatic arthritis (PsA) based on evidence obtained from a systematic review of the literature and from consensus opinion. Methods: Formal literature reviews of treatment for the most significant discrete clinical manifestations of PsA (skin and nails, peripheral arthritis, axial disease, dactylitis and enthesitis) were performed and published by members of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). Treatment recommendations were drafted for each of the clinical manifestations by rheumatologists, dermatologists and PsA patients based on the literature reviews and consensus opinion. The level of agreement for the individual treatment recommendations among GRAPPA members was assessed with an online questionnaire. Results: Treatment recommendations were developed for peripheral arthritis, axial disease, psoriasis, nail disease, dactylitis and enthesitis in the setting of PsA. In rotal, 19 recommendations were drafted, and over 80% agreement was obtained on 16 of them. In addition, a grid that factors disease severity into each of the different disease manifestations was developed to help the clinician with treatment decisions for the individual patient from an evidenced-based perspective. Conclusions: Treatment recommendations for the cardinal physical manifestations of PsA were developed based on a literature review and consensus between rheumatologists and dermatologists. In addition, a grid was established to assist in therapeutic reasoning and decision making for individual patients. It is anticipated that periodic updates will take place using this framework as new data become available.
Dendrite morphology, a neuron's anatomical fingerprint, is a neuroscientist's asset in unveiling organizational principles in the brain. However, the genetic program encoding the morphological identity of a single dendrite remains a mystery. In order to obtain a formal understanding of dendritic branching, we studied distributions of morphological parameters in a group of four individually identifiable neurons of the fly visual system. We found that parameters relating to the branching topology were similar throughout all cells. Only parameters relating to the area covered by the dendrite were cell type specific. With these areas, artificial dendrites were grown based on optimization principles minimizing the amount of wiring and maximizing synaptic democracy. Although the same branching rule was used for all cells, this yielded dendritic structures virtually indistinguishable from their real counterparts. From these principles we derived a fully-automated model-based neuron reconstruction procedure validating the artificial branching rule. In conclusion, we suggest that the genetic program implementing neuronal branching could be constant in all cells whereas the one responsible for the dendrite spanning field should be cell specific.