Medizin
Refine
Year of publication
- 2016 (316) (remove)
Document Type
- Article (282)
- Doctoral Thesis (14)
- Part of Periodical (11)
- Book (4)
- Contribution to a Periodical (3)
- Conference Proceeding (1)
- Preprint (1)
Has Fulltext
- yes (316) (remove)
Is part of the Bibliography
- no (316) (remove)
Keywords
- Mitochondria (4)
- apoptosis (4)
- Apoptosis (3)
- Cancer (3)
- HIV (3)
- ROS (3)
- autophagy (3)
- cirrhosis (3)
- ABCB1 (2)
- Aging (2)
- Angiogenesis (2)
- B-cell lymphoma (2)
- Borrelia (2)
- Calcium (2)
- Cell signalling (2)
- Cortex (2)
- CyberKnife robotic radiosurgery (2)
- Diabetes mellitus (2)
- Diagnostic markers (2)
- Exercise (2)
- Experimental models of disease (2)
- Gender (2)
- Heart transplantation (2)
- Immunotherapy (2)
- Infection (2)
- NADPH oxidase (2)
- Pain (2)
- Patient blood management (2)
- Pneumonia (2)
- Proteomics (2)
- Stereotactic body radiation therapy (2)
- Structural plasticity (2)
- VEGF (2)
- atrial fibrillation (2)
- breast cancer (2)
- cancer (2)
- caspase-8 (2)
- complementary and alternative medicine (2)
- development (2)
- diagnosis (2)
- glioblastoma (2)
- hepatitis C (2)
- human (2)
- liver transplantation (2)
- mitosis (2)
- particulate matter (2)
- renal cell carcinoma (2)
- surgery (2)
- ubiquitination (2)
- A/D transition (1)
- ABS (1)
- AGC kinase (1)
- AIH immunopathogenesis (1)
- AJAP1 (1)
- APMPPE - acute posterior multifocal placoid pigment epitheliopathy (1)
- APP (1)
- ARDS (1)
- Abdominal infections (1)
- Academic medicine (1)
- Access (1)
- Acute calcolous cholecystitis (1)
- Acute leukemia (1)
- Acute myeloid leukemia (1)
- Adherence junctions (1)
- Adolescents (1)
- Adverse events (1)
- Air traffic (1)
- All-trans retinoic acid (1)
- Allergic asthma (1)
- Allogeneic hematopoietic stem (1)
- Allogeneic stem cell transplantation (1)
- Ameloblastoma (1)
- Anaemia (1)
- Anatomy (1)
- Anemia (1)
- Anti platelet therapy (1)
- Anti-tumor immunity (1)
- Antibiotic (1)
- Antibiotic stewardship (1)
- Anticoagulation (1)
- Antimicrobial resistance (1)
- Antivenom (1)
- Arrhythmia/all (1)
- Ascites (1)
- Aspergillus fumigatus (1)
- Atherosclerosis (1)
- Atrial fibrillation (1)
- Atxn2 (1)
- Aurora (1)
- Autologous stem cell transplantation (1)
- Automated Tube Potential Selection (1)
- Automatic Environmental Tobacco Smoke Emitter (1)
- Autophagy (1)
- Azan trichrome stain (1)
- B-cell non-Hodgkin lymphoma (1)
- BMC (1)
- Backpropagating action potential (1)
- Bacterial infection (1)
- Bacterial pathogenesis (1)
- Bariatric surgery (1)
- Beatmung (1)
- Becton Dickinson (1)
- Benefit (1)
- Bibliometric analysis (1)
- Biliary tree stones (1)
- Bisphosphonates (1)
- Blood loss (1)
- Blood transfusion (1)
- Bone defect (1)
- Bone regeneration (1)
- Brain injury (1)
- Breast cancer (1)
- Breech delivery (1)
- Bungarus niger (1)
- C. elegans (1)
- CA1 (1)
- CD95/Fas receptor (1)
- CDK inhibitor (1)
- CIK cells (1)
- CNS cancer (1)
- COPD (1)
- CRISPR/Cas9 (1)
- CT pulmonary angiography (1)
- CT radiation exposure (1)
- CUELA (1)
- CYBA/p22phox (1)
- CYP1A1 (1)
- Cancer Staging (1)
- Cancer detection (1)
- Capecitabine (1)
- Carbapenem-resistente Gram-negative Bakterien (CRGN) (1)
- Carbapenemasen (1)
- Cardiac (1)
- Cardiac output (1)
- Cardiology (1)
- Cardiomyocyte signaling pathways (1)
- Cardioprotection (1)
- Cardiovascular disease (1)
- Catch-up validation study (1)
- Catheter ablation (1)
- Cats (1)
- Cdk1/cyclin B1 (1)
- Celiac disease (1)
- Cell salvage (1)
- Cell therapy (1)
- Cerebellum (1)
- Cerebral cortex (1)
- Cesarean delivery (1)
- Checkpoint inhibitor (1)
- Chemical modification (1)
- Chemiluminescence (1)
- Chemorefractory advanced gastric cancer (1)
- Chemotherapy (1)
- Children (1)
- Chimerism (1)
- Cholecystectomy (1)
- Chondral Lesion (1)
- Chorion (1)
- Chronic hepatitis (1)
- Chronic inflammation (1)
- Cigarettes (1)
- Claudin 5 (1)
- Clinical competence (1)
- Clinical genetics (1)
- Clinical skills (1)
- Clinical trial (1)
- Clinical trials (1)
- Clonidine (1)
- Clustering (1)
- Cofilin (1)
- Collagen antibody-induced arthritis (1)
- Comorbidities (1)
- Compartmental modeling (1)
- Complementary medicine (1)
- Complex I (1)
- Compliance (1)
- Computed tomography pulmonary angiography (CTPA) (1)
- Computer simulation (1)
- Conduct disorder (1)
- Congenital ocular motor apraxia (1)
- Conventional Chemotherapeutic (1)
- Cord blood transplantation (1)
- Costs (1)
- Couch tracking (1)
- Craniomandibular disorders (1)
- Critical haematocrit (1)
- Croatia (1)
- Cross-contamination (1)
- Cryo-electron microscopy (1)
- Cryoballoon (1)
- Cytotoxic CD8+ T cell (1)
- DKK1 (1)
- DNA damage (1)
- DNA methylation (1)
- DNA replication (1)
- DNA-protein crosslinks (1)
- Daptomycin (1)
- Databases (1)
- Decision making (1)
- Decision trees (1)
- Decision-making (1)
- Decolonization (1)
- Delegation (1)
- Delivery mode (1)
- Delivery quality assurance (1)
- Dendritic spines (1)
- Denosumab (1)
- Density equalizing (1)
- Density equalizing mapping (1)
- Dentistry (1)
- Desinfektion von Flugzeugen (1)
- Desmin (1)
- Diagnosis (1)
- Digital breast tomosynthesis (DBT) (1)
- Digital mammography (1)
- Disinfection of aircraft (1)
- Distribution (1)
- Dogs (1)
- Domestic (1)
- Drug targeting (1)
- Drug therapy (1)
- Dual-Source CT (1)
- Dvc1 (1)
- E-learning (1)
- E. coli (1)
- EQ (1)
- EQ-5D (1)
- ET (1)
- Early goal-directed therapy (1)
- Echocardiography (1)
- Eclampsia (1)
- Economic evaluation (1)
- Economic impact (1)
- Electron transport chain (1)
- Electrotonic analysis (1)
- Elimination (1)
- Emotion regulation (1)
- Emphysema (1)
- Employment effect (1)
- Endometriosis (1)
- Endoscopic ultrasound (1)
- Endothelial permeability (1)
- Entorhinal cortex lesion (1)
- EnvZ signalling (1)
- Envenomation (1)
- Epidermolysis bullosa simplex with muscular dystrophy (1)
- Eradication (1)
- Erythema migrans (1)
- Erythrocytes (1)
- Europe (1)
- Evaluation (1)
- Everolimus (1)
- Evidence-based medicine (1)
- Ewing sarcoma (1)
- Excitability (1)
- Exercise Metabolism (1)
- Extracellular RNA (eRNA) (1)
- FOLFIRI (1)
- Fc receptor (1)
- Feedback (1)
- Females (1)
- Fetal bovine serum (1)
- Fibrosis (1)
- First-line combination antiretroviral therapy (1)
- Fleas (1)
- Flexible Endoscopic Evaluation of Swallowing (1)
- Folic acid (1)
- Follow-up (1)
- Functional capacity (1)
- Functional clustering (1)
- GSK2334470 (1)
- GVHD (1)
- Gallbladder percutaneous drainage (1)
- Gastritis (1)
- Gastrointestinal bleeding (1)
- Gastrointestinal neoplasm (1)
- Gender analysis (1)
- Gene expression (1)
- General clinical cardiology (1)
- General practice/family medicine (1)
- Genetics research (1)
- Germany (1)
- Gestational diabetes (1)
- Gimbaled tracking (1)
- Gram-positive infection (1)
- Granule cell (1)
- Gross tumor volume optimization (1)
- Growth cone (1)
- Guideline (1)
- Guidelines (1)
- H3 receptor (1)
- HMA (1)
- Hausarztpraxis (1)
- Health care workers (1)
- Heart regeneration (1)
- Hemodilution (1)
- Hemodynamic management (1)
- Hemostasis (1)
- Hepatitis C virus (1)
- Hepatitis c (1)
- Herd immunity (1)
- High-dose chemotherapy (1)
- Highly infectious diseases (1)
- Hochansteckende Krankheiten (1)
- Hodgkin lymphoma (1)
- Hodgkin-Lymphom (1)
- Homeostasis (1)
- Homeostatic plasticity (1)
- Homocysteine (1)
- Hospital (1)
- Hospitals (1)
- Household contacts (1)
- Hrvaška (1)
- Human behaviour (1)
- Human physiology (1)
- Humans (1)
- IAP proteins (1)
- IGRA (1)
- IL-11 (1)
- IL-13 (1)
- IL-22 (1)
- IL-6 (1)
- Immobilization (1)
- Immune response (1)
- Immunity (1)
- Immunocompromised (1)
- Immunology and Microbiology Section (1)
- Immunosuppressive agents (1)
- Immunosuppressive therapy (1)
- In vitro (1)
- In vivo (1)
- Incidence (1)
- Individualized intervention (1)
- Indoor air pollution (1)
- Induced pluripotent stem cells (1)
- Infant (1)
- Inflow obstruction (1)
- Influenza (1)
- Intensive care (1)
- Intensive care unit (1)
- Interdisciplinarity (1)
- Intermediate filaments (1)
- Intratumoral (1)
- Iron deficiency anemia (1)
- Ischemia/reperfusion injury (1)
- Ischemia–reperfusion injury (1)
- Itpr1 (1)
- Jaw (1)
- Joint destruction (1)
- Joubert syndrome (1)
- Kidney transplantation (1)
- Kiefer (1)
- Kim-1 (1)
- Kinases (1)
- Kinematic posture analysis (1)
- Krait (1)
- Kraniomandibuläre Dysfunktion (1)
- LC3B (1)
- LDL-cholesterol (1)
- LOS (1)
- LTBI (1)
- Lactation (1)
- Learning outcomes (1)
- Lecture (1)
- Left ventricular assist device (1)
- Left ventricular non-compaction, (1)
- Lenalidomide (1)
- Length of stay (1)
- Lice (1)
- Lineage tracing (1)
- Lipid metabolism (1)
- Lipid signaling (1)
- Lipid signalling (1)
- Liquid filled MicroLion ion chamber array (1)
- Liver cirrhosis (1)
- Liver metastases (1)
- Long-term care (1)
- Longitudinal (1)
- Low back pain (1)
- Ltbp4 (1)
- Lucigenin (1)
- Luftverkehr (1)
- Lungenkontusion (1)
- Lyme borreliosis (1)
- Lyme disease (1)
- Lyme disease - Borreliosis (1)
- MEDIC (1)
- MLC tracking (1)
- MLL-rearranged leukemia (1)
- MMF (1)
- MPA (1)
- MPN (1)
- MPN-U (1)
- MR-based histology (1)
- MRI (1)
- MRSA (1)
- Machine-learning (1)
- Macrophage Transdifferentiation (1)
- Magnetic resonance (1)
- Major bleeding (1)
- Major infection after cardiac surgery (1)
- Mammary gland (1)
- Manufacturing (1)
- Mapping (1)
- Measles (1)
- Medizinische Fachangestellte (1)
- Meldepflicht (1)
- Membrane assays (1)
- Mental health (1)
- Mesenchymal stem/stromal cells (1)
- Metabolic diseases (1)
- Metastatic breast cancer (1)
- Methicillin resistance (1)
- MicroRNAs (miRNAs) (1)
- Migrants (1)
- Minimal residual disease (1)
- Mitochondrial complex I (1)
- Modified FDI criteria (1)
- Molar tooth sign (1)
- Molecular biology (1)
- Monacolin K (1)
- Morphological modeling (1)
- Mortality (1)
- Motor control (1)
- Multi-resistant pathogens (1)
- Multidetector Computed Tomography (1)
- Multimodal imaging (1)
- Multiple myeloma (1)
- Multiple sclerosis (1)
- Multivariate analysis (1)
- Muscarinic acetylcholine receptor (1)
- Muscular diseases (1)
- Musculoskeletal system (1)
- Muskuloskeletales System (1)
- NADH:ubiquinone oxidoreductase (1)
- NHE (1)
- NK cell (1)
- NK cell subset (1)
- NO (1)
- NS3 protease inhibitor (1)
- NSF (1)
- NXF1 (1)
- Nackenmuskulatur (1)
- Neck muscles (1)
- Neoplasms (1)
- Nerve regeneration (1)
- Nervous system diseases (1)
- Neurodegeneration (1)
- Neuroinflammation (1)
- Neurotoxicity (1)
- Nitric oxide (1)
- Non-RCT (1)
- Non-alcoholic fatty liver disease (1)
- Non-coding RNAs (1)
- Non-neuronal cholinergic system (1)
- Nonsteroidal anti-inflammatory drugs (1)
- Nox (1)
- Nox4 (1)
- Nrf2 (1)
- Nucleophosmin-1 (1)
- OECD performance standards (1)
- OPRM1 methylation (1)
- OSCE (1)
- Olfactory system (1)
- Oncolytic adenovirus (1)
- Open source concept (1)
- Oppositional defiant disorder (1)
- Organ motion (1)
- Osmosensing (1)
- Osteoporosis (1)
- Ovarian cancer (1)
- Oxygen consumption (1)
- PAR (1)
- PDK1 (1)
- PELICAN (1)
- PIF pocket (1)
- PMF (1)
- PV (1)
- Parainfluenza (1)
- Parkinson's disease (1)
- Particulate matter (1)
- Patellofemoral Joint (1)
- Pathogen reduction (1)
- Pdgfrβ (1)
- Peer-feedback (1)
- Peer-teaching (1)
- Pegylated liposomal doxorubicin (1)
- Persistence (1)
- Pharmacological treatment (1)
- Pharmacology (1)
- Phosphorylation (1)
- Physicians (1)
- Placental growth factor (1)
- Platelet (1)
- Platelet lysate (1)
- Platelet releasate (1)
- Plectin (1)
- Plk1 inhibitors (1)
- Polo-like kinase 3 (1)
- Polyhexanide (1)
- Population-based screening (1)
- Porin regulation (1)
- Post-translational modifications (1)
- Pre-economic effects (1)
- Pre-emptive immunotherapy (1)
- Pre-treatment drug resistance mutations (1)
- Preclinical research (1)
- Predictive medicine (1)
- Preeclampsia (1)
- Pregnancy (1)
- Primary care (1)
- Primärversorgung (1)
- Produkte zur Desinfektion (1)
- Progranulin (1)
- Protein aggregates (1)
- Proximal humeral fracture (1)
- Pseudo HE-images (1)
- Pulse contour analysis (1)
- Pulse pressure variation (1)
- Qualifikation (1)
- Quality of care (1)
- Quantitative MRI (1)
- RCT (1)
- RIPK3 (1)
- ROS generation (1)
- RT-qPCR (1)
- Radiofrequency (1)
- Raman spectroscopy (1)
- Randomised controlled trial (1)
- Randomized controlled trial (1)
- Rational use (1)
- Reactive oxygen species (1)
- Recall rate (1)
- Reconstructed human epidermis (1)
- Red blood cells (1)
- Red yeast rice (1)
- Redox (1)
- Regression analysis (1)
- Rehospitalization (1)
- Relapse (1)
- Relaxometry (1)
- Remote ischemic conditioning (1)
- Renal cell carcinoma (1)
- Renal function (1)
- Research architecture (1)
- Residential care (1)
- Resin composites (1)
- Respiration (1)
- Respiratory signs and symptoms (1)
- Respiratory syncytial virus (1)
- Rheumatoid arthritis (1)
- Robotic tracking (1)
- Roma women (1)
- Rora (1)
- Rotorest (1)
- Ruijs-Aalfs syndrome (1)
- Ryanodine (1)
- S. cerevisiae (1)
- SAP (1)
- SCT (1)
- SPARTAN (1)
- SPRTN (1)
- SR protein (1)
- SRSF3 (1)
- SRSF7 (1)
- STAT3 (1)
- STIR (1)
- SW480 Cell (1)
- Salmonella infection (1)
- Schmerz (1)
- Science structure (1)
- Scientometric analysis (1)
- Scientometrics (1)
- Sclerostin (1)
- Second stage of labor (1)
- Second-line treatment (1)
- Sensorimotor training (1)
- Sensory neuron (1)
- Sepsis-bundle (1)
- Sequence (1)
- Signaling (1)
- Signaling ROS (1)
- Skeletal muscle (1)
- Skeletal muscle fiber-type switching (1)
- Skills training (1)
- Skin irritation test (1)
- Skin manifestation (1)
- Smac (1)
- Smooth muscle cell (1)
- Snakebite (1)
- Socioeconomic status (1)
- Software tool (1)
- Spectral library (1)
- Sphere Formation Assay (1)
- Splice variants (1)
- Standardized operating procedures (1)
- Standardverfahren (1)
- Stroke (1)
- Stroke prevention (1)
- Stroke volume variation (1)
- Substances for disinfection (1)
- Sulfhydryl-reactivity (1)
- Sulfur metabolism (1)
- Sunitinib (1)
- Superinfection (1)
- Superoxide (1)
- Surgery (1)
- Surgical risk (1)
- Surveillance (1)
- Sympathicolysis (1)
- Synaptic plasticity (1)
- Synaptopodin (1)
- Synovial inflammation (1)
- Systematic review (1)
- Systemic treatment (1)
- T cell/histiocyte rich large B cell lymphoma (1)
- T cells (1)
- T1 (1)
- T84 colon carcinoma cells (1)
- TAX1BP1 (1)
- TRAIL (1)
- Target identification (1)
- Targeted therapy (1)
- Tax effect (1)
- Tgfβ (1)
- Therapeutics (1)
- Thermodilution (1)
- Thermoplasma (1)
- Thiol redox modification (1)
- Thromboembolism (1)
- Thrombosis (1)
- Thrombosis/hypercoagulable states (1)
- Ticks (1)
- Topoisomerase (1)
- Transfusion (1)
- Translational research (1)
- Transmembrane communication (1)
- Transmission (1)
- Trauma (1)
- Travellers (1)
- Treatment (1)
- Treatment protocol (1)
- Tumor suppressor protein (1)
- Tumorsphere Formation (1)
- Tyrosine kinase inhibitor (1)
- Tyrosine kinase inhibitor mTOR inhibition (1)
- Tyrosine kinases (1)
- USP9X (1)
- Undergraduate training (1)
- Upper respiratory tract infection (1)
- Urban (1)
- VE-cadherin (1)
- Vaccination (1)
- Vaginal breech delivery (1)
- Vaginal delivery (1)
- Value-added effect (1)
- Vascular permeability (1)
- Viral load (1)
- Virological failure (1)
- Voltage attenuation (1)
- WRNIP1 (1)
- XIAP (1)
- Zoonosis (1)
- acetaminophen (1)
- acute coronary syndrome (1)
- acute liver injury (1)
- acute myeloid leukemia (AML) (1)
- adalimumab (1)
- adenomatous polyposis (1)
- adenosine (1)
- adhesion (1)
- adipose tissue-derived stem cell (1)
- advance directive (1)
- advanced care planning (1)
- age-related macular degeneration (1)
- aging (1)
- allogeneic stem cell transplantation (1)
- allosteric regulation (1)
- alternative 3′ end processing (1)
- anal carcinoma (1)
- angiogenesis (1)
- angioplasty (1)
- angiopoietin-2 (1)
- angiopoietin-like 3 (ANGPTL3) (1)
- animal host (1)
- animal models (1)
- antenatal characteristics (1)
- antenatalne značilnosti (1)
- anti-citrullinated protein antibodies (1)
- anticoagulants (1)
- anticonvulsant activity (1)
- antiviral (1)
- antiviral therapy (1)
- archaea (1)
- archaeosomes (1)
- artery (1)
- astrocytoma (1)
- asymmetric hearing (1)
- auditory development (1)
- autoantibodies (1)
- automatic environmental tobacco smoke emitter (1)
- behavior (1)
- binaural cochlear implants (1)
- bio-absorbable mesh (1)
- biochemistry (1)
- biological mesh (1)
- biomarker (1)
- bone marrow metastasis (1)
- bone metastasis (1)
- brain metastases (1)
- brain states (1)
- brainmass (1)
- brainsize (1)
- bronchial allergen challenge (1)
- burden of illness (1)
- c1orf124 (1)
- cancer care (1)
- cancer care providers (1)
- cancer screening (1)
- candidate genes (1)
- carbapenem-resistant Gram-negative bacteria (CRGN) (1)
- carbapenemases (1)
- carboxyfluorescein (1)
- cardiovascular magnetic resonance (1)
- carotid (1)
- catheterization/diagnostic interventional (1)
- cell biology (1)
- cell death (1)
- cell transplantation (1)
- cells (1)
- central nervous system infection (1)
- chemokines: CYP2D6 model (1)
- chemoradiotherapy (1)
- chromosome segregation (1)
- chronic hepatitis C (1)
- chronic viral hepatitis (1)
- cigarette smoke (1)
- clusteranalysis (1)
- cochlear implant (1)
- cold tolerance (1)
- compaction (1)
- complement (1)
- compliance (1)
- connectional fingerprint (1)
- connective tissue (1)
- continuing education (1)
- cortical layers and areas (1)
- cross-modal plasticity (1)
- cytokine (1)
- cytokines (1)
- deaf white cat (1)
- deafness (1)
- decision making (1)
- dedifferentiation (1)
- dentate gyrus (1)
- dentist (1)
- depression (1)
- deprivation (1)
- desensitization (1)
- desmoplastic stroma (1)
- diclofenac (1)
- differentiation (1)
- diffuse large B cell lymphoma (1)
- diffusion MRI (1)
- diffusion tensor imaging (1)
- direct antiviral agents (1)
- drug resistance (1)
- eNOS (1)
- editorials (1)
- electrocardiography (1)
- endothelial (1)
- endothelial cells (1)
- endothelial receptor expression (1)
- environmental tobacco smoke (1)
- epilepsy (1)
- erosions (1)
- eutheria (1)
- exercise testing (1)
- exome sequencing (1)
- familial colorectal cancer (1)
- fasting (1)
- fear conditioning (1)
- fear generalization (1)
- fibrosarcoma (1)
- fracture (1)
- freeze avoidance (1)
- gadobutrol (1)
- gender (1)
- gene expression (1)
- gene expression profiling (1)
- gene expression profiling (GEP) (1)
- generic preparedness (1)
- glucocorticoids (1)
- gold nanoparticles (1)
- governance (1)
- graph theory (1)
- green fluorescent protein (1)
- guideline (1)
- health-related quality of life (1)
- hepatitis c (1)
- hepatocytes (1)
- hepatotoxicity (1)
- herb induced liver injury (HILI) (1)
- herbal drug (1)
- herbal hepatotoxicity (1)
- hereditary angioedema (1)
- hereditary tumor syndromes (1)
- high-dose chemotherapy (1)
- histamine (1)
- histological validation (1)
- homoarginine (1)
- hormones (1)
- host response (1)
- human brain (1)
- human gingival fibroblasts (1)
- human natural killer cell (1)
- hypoxia (1)
- iCLIP (1)
- immune evasion (1)
- immune reconstitution (1)
- immune response (1)
- immunocompromised patient (1)
- immunologic (1)
- immunostaining (1)
- in situ hybridization (1)
- in situ vaccine (1)
- incisional hernia (1)
- influenza pandemic (1)
- information needs (1)
- innate immunity (1)
- insertable cardiac monitor (1)
- interaural time difference (1)
- interferon (1)
- interferon-free antiviral treatment (1)
- invasion (1)
- irritable bowel syndrome (1)
- isomeric antagonists (1)
- kinase regulation (1)
- kinetische Therapie (1)
- laser (1)
- laser based cell manipulation (1)
- laser microdissection (1)
- leukocytes (1)
- life span (1)
- liposomes (1)
- living will (1)
- local control (1)
- low-dose imaging (1)
- lymphoma pathogenesis (1)
- l‐arginine:glycine amidinotransferase (1)
- mRNA export (1)
- macrophages (1)
- magnetic resonance imaging (1)
- mammals (1)
- management (1)
- mandatory reporting system (1)
- mantle cell lymphoma (1)
- massive parallel sequencing (1)
- maturation (1)
- medical history (1)
- menthol (1)
- men’s (1)
- meta-analysis (1)
- metabolism (1)
- metalloprotease (1)
- miRNA (1)
- microbiome (1)
- microwave ablation (1)
- mismatch repair (1)
- mitotic arrest (1)
- molecular dynamics (1)
- mouse (1)
- multi-drug resistance (1)
- multidrug-resistant Gram-negative bacteria (MRGN) (1)
- multiresistente Gram-negativen Stäbchenbakterien (MRGN) (1)
- neuroblastoma (1)
- neuroinformatics (1)
- neuromodulation (1)
- nodular lymphocyte predominant Hodgkin lymphoma (1)
- noise intervention measures (1)
- nonnucleoside polymerase inhibitor (1)
- non‑Hodgkin's lymphoma (1)
- nuclear hormone receptor (1)
- nursery schools (1)
- observational study (1)
- occupational health (1)
- occupational stress (1)
- oncology (1)
- oral enzyme combination (1)
- orthodontist (1)
- osteoarthritis (1)
- osteoporosis (1)
- osteoporosis treatment (1)
- oval split ring resonator (1)
- p21 phosphorylation (1)
- p21 stability (1)
- pandemic preparedness (1)
- patient’s desires (1)
- pattern (1)
- perforin (1)
- perfusion (1)
- perinatal HIV infection (1)
- periodontal diseases (1)
- periodontitis (1)
- peripheral blood stem cell transplant (1)
- pirinixic acid (1)
- pirinixic acid derivative (1)
- pixantrone (1)
- pol g (1)
- pollen allergy (1)
- polo-like kinase (1)
- polycystic kidney (1)
- post hoc study (1)
- prefrontal cortex (1)
- prevention (1)
- progenitor (1)
- progeria (1)
- prognosis (1)
- proliferation (1)
- prophylaxis (1)
- protein kinase (1)
- proximal tubule (1)
- psoriatic arthritis (1)
- public health. (1)
- radiological (1)
- randomized controlled trial (1)
- rat model (1)
- real-world data (1)
- renal impairment (1)
- retuximab (1)
- risk communication (1)
- rituximab (1)
- romske ženske (1)
- salvage therapy (1)
- schizophrenia (1)
- senescence (1)
- sensory deprivation (1)
- sex‑determining region Y-box 11 (1)
- signature (1)
- single‐photon emission (1)
- size of cigarettes (1)
- skin conductance (1)
- skin involvement (1)
- sleep (1)
- slow-wave rhythms (1)
- smac mimetic (1)
- small compounds (1)
- sound analyses (1)
- sphingolipid (1)
- spirochetes (1)
- stellate reticulum (1)
- stereoselectivity (1)
- stress (1)
- stress response (1)
- stroke prevention (1)
- sulforaphane (1)
- survey (1)
- systematic review (1)
- targeted therapy (1)
- teratoma (1)
- testosterone (1)
- tetraether lipid (1)
- theranostics (1)
- therapy at the end of life (1)
- tobacco taxation (1)
- tolerance (1)
- training (1)
- treatment (1)
- trophiclevel (1)
- tumor immune escape (1)
- ubiquitin (1)
- ubiquitin coat (1)
- ubiquitin-binding zinc finger (1)
- ultra-high field MRI (1)
- vascular endothelial growth factor (1)
- vertebrates (1)
- vessel density (1)
- virological failure (1)
- waking state (1)
- wax layer (1)
- western blotting (1)
- winter survival (1)
- work ability (1)
- working conditions (1)
- xenobiotics (1)
- xenophagy (1)
- young people (1)
- μ-opioid receptor regulation (1)
Institute
- Medizin (316)
- Präsidium (11)
- Biowissenschaften (8)
- Exzellenzcluster Makromolekulare Komplexe (6)
- Biochemie und Chemie (5)
- Pharmazie (5)
- Sonderforschungsbereiche / Forschungskollegs (4)
- Georg-Speyer-Haus (3)
- MPI für Hirnforschung (3)
- Sportwissenschaften (3)
Multidrug-resistant Gram-negative bacteria (MDR GNB) were found to colonise 60.8% (95% confidence interval: 52.3–68.9) of 143 refugee patients mainly from Syria (47), Afghanistan (29), and Somalia (14) admitted to the University Hospital Frankfurt, Germany, between June and December 2015. This percentage exceeds the prevalence of MDR GNB in resident patients four–fold. Healthcare personnel should be aware of this and the need to implement or adapt adequate infection control measures.
Repetitive transcranial magnetic stimulation (rTMS) is used as a therapeutic tool in neurology and psychiatry. While repetitive magnetic stimulation (rMS) has been shown to induce plasticity of excitatory synapses, it is unclear whether rMS can also modify structural and functional properties of inhibitory inputs. Here we employed 10-Hz rMS of entorhinohippocampal slice cultures to study plasticity of inhibitory neurotransmission on CA1 pyramidal neurons. Our experiments reveal a rMS-induced reduction in GABAergic synaptic strength (2–4 h after stimulation), which is Ca2+-dependent and accompanied by the remodelling of postsynaptic gephyrin scaffolds. Furthermore, we present evidence that 10-Hz rMS predominantly acts on dendritic, but not somatic inhibition. Consistent with this finding, a reduction in clustered gephyrin is detected in CA1 stratum radiatum of rTMS-treated anaesthetized mice. These results disclose that rTMS induces coordinated Ca2+-dependent structural and functional changes of specific inhibitory postsynapses on principal neurons.
Background: Guidelines for the control of hospital-acquired MRSA include decolonization measures to end MRSA carrier status in colonized and infected patients. Successful decolonization typically requires up to 22 days of treatment, which is longer than the average hospital length of stay (LOS). Incomplete decolonization is therefore common, with long-term MRSA carriage as a consequence. To overcome this, we developed an integrated MRSA Management (IMM) by extending MRSA decolonization to the outpatient and domestic setting. The protocol makes use of polyhexanide-based products, in view of reported qac-mediated resistance to chlorhexidine in S. aureus and MRSA.
Methods: This is a prospective, single centre, controlled, non-randomized, open-label study to evaluate the efficiency of the IMM concept. The outcome of guideline-approved decolonization during hospital stay only (control group; n = 201) was compared to the outcome following IMM treatment whereby decolonization was continued after discharge in the domestic setting or in a long-term care facility (study group; n = 99). As a secondary outcome, the effect of MRSA-status of skin alterations was assessed.
Results: The overall decolonization rate was 47 % in the IMM patient group compared to 12 % in the control group (p < 0.01). The continued treatment after hospital discharge was as effective as treatment completed during hospitalization, with microbiologically-confirmed decolonization (patients with completed regimes only) obtained with 55 % for the IMM group and 43 % for the control group (p > 0.05). For patients with skin alterations (e.g. wounds and entry sites), decolonization success was 50 % if the skin alterations were MRSA-negative at baseline, compared to 22 % success for patients entering the study with MRSA-positive skin alterations (p < 0.01).
Conclusions: The IMM strategy offers an MRSA decolonization protocol that is feasible in the domestic setting and is equally effective compared with inpatient decolonization treatment when hospital LOS is long enough to complete the treatment. Moreover, for patients with average LOS, decolonization rates obtained with IMM are significantly higher than for in-hospital treatment. IMM is a promising concept to improve decolonization rates of MRSA-carriers for patients who leave the hospital before decolonization is completed.
Acute calculus cholecystitis is a very common disease with several area of uncertainty. The World Society of Emergency Surgery developed extensive guidelines in order to cover grey areas. The diagnostic criteria, the antimicrobial therapy, the evaluation of associated common bile duct stones, the identification of “high risk” patients, the surgical timing, the type of surgery, and the alternatives to surgery are discussed. Moreover the algorithm is proposed: as soon as diagnosis is made and after the evaluation of choledocholitiasis risk, laparoscopic cholecystectomy should be offered to all patients exception of those with high risk of morbidity or mortality. These Guidelines must be considered as an adjunctive tool for decision but they are not substitute of the clinical judgement for the individual patient.
Background: Use of blood oxygenation level-dependent cardiovascular magnetic resonance (BOLD-CMR) to assess perfusion in the lower limb has been hampered by poor reproducibility and a failure to reliably detect post-revascularization improvements in patients with critical limb ischemia (CLI).
Objectives: This study sought to develop BOLD-CMR as an objective, reliable clinical tool for measuring calf muscle perfusion in patients with CLI.
Methods: The calf was imaged at 3-T in young healthy control subjects (n = 12), age-matched control subjects (n = 10), and patients with CLI (n = 34). Signal intensity time curves were generated for each muscle group and curve parameters, including signal reduction during ischemia (SRi) and gradient during reactive hyperemia (Grad). BOLD-CMR was used to assess changes in perfusion following revascularization in 12 CLI patients. Muscle biopsies (n = 28), obtained at the level of BOLD-CMR measurement and from healthy proximal muscle of patients undergoing lower limb amputation (n = 3), were analyzed for capillary-fiber ratio.
Results: There was good interuser and interscan reproducibility for Grad and SRi (all p < 0.0001). The ischemic limb had lower Grad and SRi compared with the contralateral asymptomatic limb, age-matched control subjects, and young control subjects (p < 0.001 for all comparisons). Successful revascularization resulted in improvement in Grad (p < 0.0001) and SRi (p < 0.0005). There was a significant correlation between capillary-fiber ratio (p < 0.01) in muscle biopsies from amputated limbs and Grad measured pre-operatively at the corresponding level.
Conclusions: BOLD-CMR showed promise as a reliable tool for assessing perfusion in the lower limb musculature and merits further investigation in a clinical trial.
Acetaminophen (APAP, N-acetyl-p-aminophenol, or paracetamol) overdosing is a prevalent cause of acute liver injury. While clinical disease is initiated by overt parenchymal hepatocyte necrosis in response to the analgetic, course of intoxication is substantially influenced by associated activation of innate immunity. This process is supposed to be set in motion by release of danger-associated molecular patterns (DAMPs) from dying hepatocytes and is accompanied by an inflammatory cytokine response. Murine models of APAP-induced liver injury emphasize the complex role that DAMPs and cytokines play in promoting either hepatic pathogenesis or resolution and recovery from intoxication. Whereas the function of key inflammatory cytokines is controversially discussed, a subclass of specific cytokines capable of efficiently activating the hepatocyte signal transducer and activator of transcription (STAT)-3 pathway stands out as being consistently protective in murine models of APAP intoxication. Those include foremost interleukin (IL)-6, IL-11, IL-13, and IL-22. Above all, activation of STAT3 under the influence of these cytokines has the capability to drive hepatocyte compensatory proliferation, a key principle of the regenerating liver. Herein, the role of these specific cytokines during experimental APAP-induced liver injury is highlighted and discussed in a broader perspective. In hard-to-treat or at-risk patients, standard therapy may fail and APAP intoxication can proceed toward a fatal condition. Focused administration of recombinant STAT3-activating cytokines may evolve as novel therapeutic approach under those ill-fated conditions.
Background: Among cancer care providers (CCPs), lack of knowledge constitutes an important barrier to the discussion of complementary and alternative medicine (CAM) use with patients. This study assessed CCPs’ needs and preferences regarding CAM information and training (I&T).
Methods: An online survey was completed by 209 general practitioners, 437 medical specialists, 159 oncology nurses and medical assistants, and 244 psychologists and social workers engaged in cancer care. Latent class analysis (LCA) was used to identify subgroups of individuals with distinct preference patterns regarding I&T content.
Results: CCPs prefer CAM I&T to be provided as lectures, information platforms on the internet, workshops, and e-mail newsletters. Concerning subject matters, many CCPs considered CAM therapy options for the treatment of a variety of cancer disease- and therapy-related symptoms to be very important (75%-72% of the sample); the same applies to an "overview of different CAM therapies" (74%). LCA identified 5 latent classes (LCs) of CCPs. All of them attached considerable importance to "medical indication," "potential side effects," and "tips for usage." LCs differed, however, in terms of overall importance ratings, the perceived importance of "patients’ reasons" for using specific CAM therapies, "case examples," and "scientific evidence." Notably, the 5 LCs were clearly present in all 4 occupational groups.
Conclusions: CAM I&T should provide CCPs with an overview of different CAM therapies and show how CAM might help in treating symptoms cancer patients frequently demonstrate (eg, fatigue). Moreover, I&T programs should be flexible and take into account that individual information needs vary even within the same occupational group.
Serum levels of the lipid mediator sphingosine-1-phosphate (S1P) are reduced in septic patients and are inversely associated with disease severity. We show that serum S1P is reduced in human sepsis and in murine models of sepsis. We then investigated whether pharmacological or genetic approaches that alter serum S1P may attenuate cardiac dysfunction and whether S1P signaling might serve as a novel theragnostic tool in sepsis. Mice were challenged with lipopolysaccharide and peptidoglycan (LPS/PepG). LPS/PepG resulted in an impaired systolic contractility and reduced serum S1P. Administration of the immunomodulator FTY720 increased serum S1P, improved impaired systolic contractility and activated the phosphoinositide 3-kinase (PI3K)-pathway in the heart. Cardioprotective effects of FTY720 were abolished following administration of a S1P receptor 2 (S1P2) antagonist or a PI3K inhibitor. Sphingosine kinase-2 deficient mice had higher endogenous S1P levels and the LPS/PepG-induced impaired systolic contractility was attenuated in comparison with wild-type mice. Cardioprotective effects of FTY720 were confirmed in polymicrobial sepsis. We show here for the first time that the impaired left ventricular systolic contractility in experimental sepsis is attenuated by FTY720. Mechanistically, our results indicate that activation of S1P2 by increased serum S1P and the subsequent activation of the PI3K-Akt survival pathway significantly contributes to the observed cardioprotective effect of FTY720.
Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma
(2016)
Chest trauma has a significant relevance on outcome after severe trauma. Clinically, impaired lung function typically occurs within 72 hours after trauma. However, the underlying pathophysiological mechanisms are still not fully elucidated. Therefore, we aimed to establish an experimental long-term model to investigate physiological, morphologic and inflammatory changes, after severe trauma. Male pigs (sus scrofa) sustained severe trauma (including unilateral chest trauma, femur fracture, liver laceration and hemorrhagic shock). Additionally, non-injured animals served as sham controls. Chest trauma resulted in severe lung damage on both CT and histological analyses. Furthermore, severe inflammation with a systemic increase of IL-6 (p = 0.0305) and a local increase of IL-8 in BAL (p = 0.0009) was observed. The pO2/FiO2 ratio in trauma animals decreased over the observation period (p < 0.0001) but not in the sham group (p = 0.2967). Electrical Impedance Tomography (EIT) revealed differences between the traumatized and healthy lung (p < 0.0001). In conclusion, a clinically relevant, long-term model of blunt chest trauma with concomitant injuries has been developed. This reproducible model allows to examine local and systemic consequences of trauma and is valid for investigation of potential diagnostic or therapeutic options. In this context, EIT might represent a radiation-free method for bedside diagnostics.