570 Biowissenschaften; Biologie
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Maintenance of genomic integrity is essential to avoid cellular transformation, neoplasia, or cell death. DNA synthesis, mitosis, and cytokinesis are important cellular processes required for cell division and the maintenance of cellular homeostasis; they are governed by many extra- and intra-cellular stimuli. Progression of normal cell division depends on cyclin interaction with cyclin-dependent kinases (Cdk) and the degradation of cyclins before chromosomal segregation through ubiquitination. Multiple checkpoints exist and are conserved in the cell cycle in higher eukaryotes to ensure that if one fails, others will take care of genomic integrity and cell survival. Many genes act as either positive or negative regulators of checkpoint function through different kinase cascades, delaying cell cycle progression to repair the DNA lesions and breaks, and assuring equal segregation of chromosomes to daughter cells. Understanding the checkpoint pathways and genes involved in the cellular response to DNA damage and cell division events in normal and cancer cells, provides information about cancer predisposition, and suggests design of small molecules and other strategies for cancer therapy. Key Words: ATM-ATR; ATM/ATR; Aurora kinases; BRCAl; Cdc6; Cdc25; Cdc27-Cdc20/CdhI; Cell cycle; CENP-E; centrosome; checkpoint; Chkl/Chk2; cyc1in-Cdk; cyclindependent kinase inhibitors (CKI); hATRIP; Mad/Bub; MCM; MgcRacGAP; microtubule-associated proteins (MAPs); mitotic exit network (MEN); Mpsl; NIMA kinases; ORC; p53; PCNA; PBK-Akt; Plk; Rad50-Nbsl-Mrell; Ran-GTP; Ras; RB-E2F; SMC; Teml.
Total body water increases in pregnancy and while the uterus, placenta, fetus, and amniotic fluid constitute part of this increase, the largest component is in the extracellular water. Fat stores also increase and thus the distribution volumes of all drugs expand, but the major effect is seen in polar drugs which are confined to the extracellular space. Cardiac output and renal function also increase and elimination of polar drugs is acelerated. In contrast, the elimination of lipophilic drugs may be retarded, and the effect on intermediate drugs is variable. Polar drugs cross the placenta slowly and accumulate in amniotic fluid and therefore in the fetal gut lumen. Lipophilic drugs cross the placenta rapidly and their transplacental distribution is dependent on relative maternal and fetal affinity: this is determined largely by protein binding on either side of the placenta. The. fetus and neonate dispose of all drugs less rapidly than adults, the most efficient elimination processes being sulphate conjugation and renal excretion.
Through the kind assistance of O. G. Lloyd of Cincinnati, Ohio, most of the Australian polypores in our possession have been accurately identified. In the present paper we record our various collections. In doing so, we make use of the excellent keys employed by Lloyd in the following works: "Synopsis of the Genus Hexagona" (Ohio, 1910), "Synopsis of the Stipitate PoIyporoids" (Ohio, 1912), "Synopsis of the Section Apus of the Genus Polyporus" (Ohio, 1915) and "Synopsis of the Genus Fomes" (Ohio, 1915). In addition to recording the plants we have handled, we have included as well all the Australian species embraced in these works. Australian mycologists should thus have available a workable scheme for the identification of most of our firmer polypores. Those who have attempted to work out the species from Cooke´s "Handbook of Australian Fungi", will appreciate the value of Lloyd´s work. We deal first with the Stipitate Polypores, then with Fomes, Polyporus (Apus) and Hexagona.