Article
Refine
Year of publication
- 2019 (500) (remove)
Document Type
- Article (500) (remove)
Has Fulltext
- yes (500)
Is part of the Bibliography
- no (500)
Keywords
- inflammation (10)
- glioblastoma (8)
- cancer (7)
- Breast cancer (6)
- biomarker (6)
- Inflammation (5)
- breast cancer (5)
- immunotherapy (5)
- mTOR (5)
- Biomarkers (4)
- Chemotherapy (4)
- Gene expression (4)
- Human behaviour (4)
- Oncology (4)
- autophagy (4)
- cirrhosis (4)
- fMRI (4)
- glioma (4)
- hypoxia (4)
- infection (4)
- invasion (4)
- macrophage (4)
- microRNA (4)
- mitochondria (4)
- Aortic valve (3)
- Cancer treatment (3)
- Children (3)
- Cirrhosis (3)
- Death rates (3)
- Depression (3)
- Drug therapy (3)
- Germany (3)
- HDAC (3)
- Hemorrhage (3)
- Immunotherapy (3)
- Mental health and psychiatry (3)
- Molecular neuroscience (3)
- Multivariate analysis (3)
- Neutropenia (3)
- Outcome (3)
- Predictive markers (3)
- Prognosis (3)
- Prävention (3)
- Quality of life (3)
- Research article (3)
- T cells (3)
- acute coronary syndrome (3)
- angiogenesis (3)
- complications (3)
- cytokines (3)
- differentiation (3)
- efficacy (3)
- epilepsy (3)
- integrin (3)
- leukemia (3)
- macrophage polarization (3)
- macrophages (3)
- monocytes (3)
- mycophenolic acid (3)
- neoadjuvant therapy (3)
- p21 (3)
- peripheral artery disease (3)
- prevention (3)
- reactive oxygen species (3)
- risk factors (3)
- sepsis (3)
- surgery (3)
- tumor microenvironment (3)
- vitamin D (3)
- Acute inflammation (2)
- Acute myeloid leukemia (2)
- Adverse events (2)
- Age groups (2)
- Alpelisib (2)
- Apoptosis (2)
- Aspergillus fumigatus (2)
- Atezolizumab (2)
- B cells (2)
- Biomarker (2)
- Body mass index (2)
- CAD/CAM (2)
- CC16 (2)
- CDKN1A (2)
- CIK cells (2)
- Cancer (2)
- Cancer chemotherapy (2)
- Cancer genomics (2)
- Cardiac hypertrophy (2)
- Cell differentiation (2)
- Cell proliferation (2)
- Clinical presentation (2)
- Cognition (2)
- Crohn’s disease (2)
- Cytokines (2)
- DMEK (2)
- DNA methylation (2)
- Developmental biology (2)
- Diagnostic medicine (2)
- Digestive system procedures (2)
- EGFR (2)
- Ears (2)
- Ejection fraction (2)
- Endothelial cells (2)
- Epidemiology (2)
- Fatty liver (2)
- HBV (2)
- HSV (2)
- Heart (2)
- Heart failure (2)
- Hepatitis C virus (2)
- Hospitals (2)
- Hypertension (2)
- IBD (2)
- Incidence (2)
- Infectious diseases (2)
- Inflammatory diseases (2)
- Ischemia (2)
- Katherine (2)
- Knowledge (2)
- Liver diseases (2)
- MYC (2)
- Machine learning (2)
- Macrophages (2)
- Magnetic resonance imaging (2)
- Mammakarzinom (2)
- Mesenchymal stem cells (2)
- Messenger RNA (2)
- Metastasen (2)
- Molecular medicine (2)
- Mouse (2)
- NADPH oxidase (2)
- Obesity (2)
- Ophthalmology (2)
- Outcomes (2)
- PARP (2)
- PD-L1 (2)
- PD‑L1 (2)
- PI3K (2)
- Patients (2)
- Pediatric infections (2)
- Personalized medicine (2)
- Pregnancy (2)
- Psychiatric disorders (2)
- RITA (2)
- Radiomics (2)
- Sepsis (2)
- Sleep (2)
- Stroke (2)
- Suicide (2)
- Supportivtherapie (2)
- Surgery (2)
- Surgical and invasive medical procedures (2)
- Surgical oncology (2)
- Transcription factors (2)
- Treatment (2)
- T‑DM1 (2)
- additives (2)
- adjuvant therapy (2)
- adjuvante Therapie (2)
- advanced (2)
- aged (2)
- alirocumab (2)
- alpelisib (2)
- antiviral therapy (2)
- apoptosis (2)
- arteriogenesis (2)
- astrocytes (2)
- atezolizumab (2)
- attention (2)
- bone metabolism (2)
- brain metastases (2)
- caspase-2 (2)
- cholesterol (2)
- chronic kidney disease (2)
- classical Hodgkin lymphoma (2)
- cognition (2)
- colorectal cancer (2)
- complement (2)
- corneal edema (2)
- corneal transplantation (2)
- curcumin (2)
- cyclosporin A (2)
- cytomegalovirus (2)
- data science (2)
- dementia (2)
- dental implant (2)
- early breast cancer (2)
- echocardiography (2)
- eicosanoids (2)
- electrolytic cleaning (2)
- environmental tobacco smoke (2)
- extracellular matrix (2)
- fortgeschritten (2)
- frühes Mammakarzinom (2)
- graph theory (2)
- heart failure (2)
- hematopoietic stem cell transplantation (2)
- hepatitis C virus (2)
- human (2)
- immune evasion (2)
- innate immunity (2)
- integrins (2)
- liver disease (2)
- lncRNA (2)
- magnetic resonance imaging (2)
- metabolic syndrome (2)
- metastatic (2)
- methylprednisolone (2)
- migration (2)
- modularity (2)
- mortality (2)
- multiple sclerosis (2)
- music (2)
- neoadjuvante Therapie (2)
- obesity (2)
- osteoporosis (2)
- particulate matter (2)
- periimplantitis (2)
- pharmacovigilance (2)
- phosphorylation (2)
- portal hypertension (2)
- primary care (2)
- primary health care (2)
- proliferation (2)
- prostaglandins (2)
- prostate cancer (2)
- proteome (2)
- proteomics (2)
- psoriasis (2)
- quantitative MRI (2)
- radical prostatectomy (2)
- radiotherapy (2)
- registry (2)
- renal function (2)
- secretome (2)
- signal transduction (2)
- sphingosine-1-phosphate (2)
- supportive therapy (2)
- targeted therapy (2)
- transplantation (2)
- trauma (2)
- tumor-associated macrophages (2)
- uteroglobin (2)
- (novel) brominated flame retardants ((N)BFR) (1)
- (surface) partial differential equations (1)
- 15-PGDH (1)
- 3Cs technology (1)
- 3D spatiotemporal resolved mathematical models (1)
- 3D tissue models (1)
- 3years (1)
- 5' UTR (1)
- 6-Schritt-Methode (1)
- A375 human melanoma cell line (1)
- AB-serum (1)
- ACL (1)
- ACLF (1)
- AICAR (1)
- AIS (1)
- ALF (1)
- AMD3100 (1)
- AML (1)
- AMPK (1)
- APRI (1)
- ASCT (1)
- AT-101 (1)
- ATG4 (1)
- ATG8 (1)
- ATM (1)
- ATO (1)
- AVM hemorrhage (1)
- Abdominal surgery (1)
- Abdominal trauma (1)
- Abiraterone acetate (1)
- Actinomycin D (1)
- Action potential (1)
- Addison’s disease (1)
- Adenocarcinoma (1)
- Adhesins (1)
- Adhesion (1)
- Adipose-derived mesenchymal stem cells (1)
- Adjustment of dosage at steady state (1)
- Adolescents (1)
- Agoraphobia (1)
- Akutes Koronarsyndrom (1)
- Alleles (1)
- Allergen immunotherapy (1)
- Allergoid (1)
- Aminotransferases (1)
- Anemia (1)
- Anesthesia, Intravenous (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Aneurysms (1)
- Angiogenesis (1)
- Angiography (1)
- Anosmia (1)
- Antibody isotypes (1)
- Anticoagulants [MeSH] (1)
- Anticoagulation (1)
- Antigen-presenting cells (1)
- Antigens (1)
- Antiplatelet therapy (1)
- Antireflux surgery (1)
- Antiviral therapy (1)
- Anura (1)
- Aortic aneurysm (1)
- Aortic arch replacement (1)
- Aortic dissection (1)
- Aortic stenosis (1)
- Aortic stiffness (1)
- Aortic valve replacement (1)
- Aortic valve sparing (1)
- Apes (1)
- Arabin pessary (1)
- Arabin-Pessar (1)
- ArchT (1)
- Aromatase Inhibitors (1)
- Arrhythmia (1)
- Artificial intelligence (1)
- Aspergillus species (1)
- Asphyxia (1)
- Ataxia telangiectasia (1)
- Atelopus carbonerensis (1)
- Atelopus mucubajiensis (1)
- Atelopus tamaense (1)
- Atrial fibrillation (1)
- Attention (1)
- Attitude (1)
- Audio equipment (1)
- Audio signal processing (1)
- Audiology (1)
- Aurora A (1)
- Aurora Ax (1)
- Australia (1)
- Austria (1)
- Automated sRNA analysis (1)
- Autophagy (1)
- Awareness (1)
- Axon (1)
- B cell malignancies (1)
- B cell precursor acute lymphoblastic leukemia (1)
- B-cell antigen receptor (1)
- BBB (1)
- BCL2 (1)
- BI1361849 (1)
- BIAM switch assay (1)
- BMAC (1)
- BNC2 (1)
- BRAF mutation (1)
- Back pain (1)
- Bartonella (1)
- Biliary tree (1)
- Bilirubin (1)
- Biomarkers & Diagnostic Imaging (1)
- Biotechnology (1)
- Bipolar disorder (1)
- Blood (1)
- Blood groups (1)
- Blood plasma (1)
- Blood pressure (1)
- Blood-brain barrier (1)
- BluePrint (1)
- Body-contouring surgery (1)
- Bone marrow (1)
- Bone marrow aspirate concentrate (1)
- Bone marrow aspiration (1)
- Bone strength assessment (1)
- Borrelia (1)
- Brain metastasis (1)
- Breast neoplasms (1)
- Breast tumors (1)
- Bufonidae (1)
- Burst (1)
- C-reactive protein (1)
- C-reactive proteins (1)
- C1 esterase inhibitor (human) (1)
- C1-esterase inhibitor protein (1)
- C3M (1)
- C4M (1)
- CAM (1)
- CD271 (1)
- CD3/CD19 depletion (1)
- CD36 (1)
- CD45RA naïve lymphocytes (1)
- CD8+ T lymphocytes (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CHA2DS2-VASc-score (1)
- CHIP (1)
- CLP (1)
- CREB inhibitor (1)
- CRISPR/Cas (1)
- CRM (1)
- CRT-D (1)
- CTLA-4 (1)
- CV9202 (1)
- CVD biomarker (1)
- CVID (1)
- CWS Studiengruppe (1)
- CXCL12 (1)
- Caco-2 cells (1)
- Canada (1)
- Cancer detection and diagnosis (1)
- Cancer epidemiology (1)
- Cancer genetics (1)
- Cancer risk factors (1)
- Cancer therapeutic resistance (1)
- Cannabis (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac device therapy (1)
- Cardiac monitoring (1)
- Cardiac necroenzymes (1)
- Cardiac remodelling (1)
- Cardiology (1)
- Cardiovascular Magnetic Resonance (CMR) (1)
- Cardiovascular epidemiology (1)
- Case management [MeSH] (1)
- Cell binding (1)
- Cell biology (1)
- Cell motility (1)
- Cell therapy (1)
- Cellular stress responses (1)
- Center-specific time in therapeutic range (cTTR) (1)
- Central nervous system metastases (1)
- Cerebral toxoplasmosis HIV (1)
- Cerebral vasospasm (1)
- Cesarean section (1)
- Chaperone (1)
- Chemical company (1)
- Chemosensitivity (1)
- Chlorides (1)
- Cholesterin (1)
- Chromatin accessibility (1)
- Chronic disease [MeSH] (1)
- Chronic health condition (1)
- Chronic hepatitis (1)
- Chronic hepatitis C virus (1)
- Chronic kidney disease (1)
- Chronic obstructive pulmonary disease (1)
- Citation analysis (1)
- Clincial pharmacology (1)
- Clinical effectiveness (1)
- Clinical pathways (1)
- Clinical studies (1)
- Clinical trial (1)
- Clostridioides difficile (1)
- Cognitive impairment (1)
- Cognitive neuroscience (1)
- Cognitive psychology (1)
- Colchicum (1)
- Collagen (1)
- Collagens (1)
- Colloids (1)
- Colorectal cancer (1)
- Combined immune checkpoint blockade (1)
- Community based intervention (1)
- Community health services (1)
- Comparative analysis (1)
- Complement cascade (1)
- Complication management (1)
- Comprehensive cancer centers (1)
- Computational biology and bioinformatics (1)
- Computational model (1)
- Computational sRNA analysis (1)
- Conduct disorder (1)
- Congenital duodenal obstruction (1)
- Contrast-enhanced (1)
- Cornea (1)
- Coronary heart disease (1)
- Cost-effectiveness (1)
- Cost-effectiveness analysis (1)
- Costs (1)
- Crispr/Cas (1)
- Cross-frequency coupling (1)
- Cross-sectional study (1)
- Cumulative dose (1)
- Cure (1)
- Curvilinear dose response (1)
- Cytochrome P450 enzymes (1)
- Cytogenetics (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytoskeletal proteins (1)
- Cytoskeleton (1)
- C‐reactive protein (1)
- DDA (1)
- DDIT4 (1)
- DHA (1)
- DILI (1)
- DME (1)
- DNA damage (1)
- DNA damage response (1)
- DNA repair (1)
- DNA-binding proteins (1)
- DNase1-seq (1)
- DSAEK (1)
- DUBs (1)
- Data mining (1)
- Data processing (1)
- Data science (1)
- David technique (1)
- Decision (1)
- Decision impact (1)
- Decision trees (1)
- Delayed union (1)
- Deletion mutation (1)
- Dental education (1)
- Dental students (1)
- Diagnosis (1)
- Diagnostic markers (1)
- Diagnostic test (1)
- Direct Acting Antivirals (DAA) (1)
- Direct acting antiviral therapies (1)
- Disabling back pain (1)
- Disease burden (1)
- Docetaxel (1)
- Dog (1)
- Dopamine (1)
- Dorsolateral prefrontal cortex (1)
- Doxorubicin (1)
- Dual energy CT (1)
- Duodenal atresia (1)
- Duodenal stenosis (1)
- E protein structure (1)
- EEG (1)
- EGFP (1)
- EGFR inhibitor (1)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (1)
- EPA (1)
- ERK3/MAPK6 (1)
- ERM (1)
- ERP (1)
- Economic analysis (1)
- Economics (1)
- Edentulous jaw (1)
- Education (1)
- Eicosanoids (1)
- Einreibetechnik (1)
- Electrical accident (1)
- Electrical stimulation (1)
- Electroencephalography – EEG (1)
- Electrolytes (1)
- Electrophysiology (1)
- Emergency (1)
- Emotion processing (1)
- Emotion regulation (1)
- Emotions (1)
- Empfehlungen (1)
- Employment (1)
- EndMT (1)
- Endoscopy (1)
- Ensemble learning (1)
- Enterobacteriaceae (1)
- Entfernung (1)
- Enzyme regulation (1)
- Enzyme-linked immunoassays (1)
- Epilepsy (1)
- Erythropoiesis (1)
- Esophageal adenocarcinoma (1)
- Esophageal adenocarcinoma (EAC) (1)
- Esophagectomy (1)
- Estrogen Receptor Modulators (1)
- Eukaryotic sRNA (1)
- Europe (1)
- European Society for Immunodeficiencies (ESID) (1)
- Evaluation (1)
- Evaluationspraxis (1)
- Evidence based medicine (1)
- Exercise challenge at an ambient temperature (1)
- Exercise challenge in a cold chamber (1)
- Exercise-induced bronchoconstriction (1)
- Experimental models of disease (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extracellular matrix proteins (1)
- Extracellular signal-regulated kinase 1/2 (1)
- Eyes (1)
- FAK (1)
- FFLU (1)
- FFPE (1)
- FIB-4 (1)
- Fatty acids (1)
- FemNAT-CD (1)
- Female adolescents (1)
- Femoral neck (1)
- Fevers (1)
- Fibroblast growth factor (1)
- Fibronectin (1)
- Fibrosis (1)
- Filovirus cell entry; attachment factors redundancy; SH-SY5Y cell line; host–pathogen interactions (1)
- Finite Volumes (1)
- First site of metastatic disease (1)
- Fistula (1)
- Flaps (1)
- Fluorescence-in-situ-hybridization (FISH) (1)
- Foramen ovale (1)
- Forkhead box (1)
- Fracture risk (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Frühgeburt (1)
- Functional electrical stimulation (1)
- Functional magnetic resonance imaging (1)
- Functional outcome (1)
- Funding (1)
- FungiScope® registry (1)
- G-protein (1)
- G/P (1)
- GRK2 (1)
- Gait analysis (1)
- Galleria mellonella (1)
- Gastric cancer (1)
- Gastroesophageal reflux disease (1)
- Gastroesophageal reflux disease symptoms (1)
- Gaucher disease type III (1)
- Gaucher’s disease (1)
- Gender reassigning surgery (1)
- Gene prediction (1)
- Gene regulation (1)
- General practice (1)
- General practitioner (1)
- General practitioners (1)
- Generation Y (1)
- Genome annotation (1)
- Genomic instability (1)
- German PID-NET registry (1)
- German people (1)
- Gleason upgrading (1)
- Glioblastoma (1)
- Global health (1)
- Glomerular Filtration Rate (1)
- Glucose Transporter Type 1 (1)
- Glycogen synthase kinase 3 beta (1)
- Goserelin (1)
- Grafts (1)
- Gram-negative bacteria (1)
- Grass pollen (1)
- Growth factors (1)
- Guided surgery (1)
- HAEGARDA (1)
- HAI‐1 (1)
- HCV (1)
- HDACi (1)
- HER2/neu (ERBB2) (1)
- HGF (1)
- HIF1α (1)
- HIV (1)
- HNSCC (1)
- HOD (1)
- HODE (1)
- HPV (1)
- HSV-1 (1)
- HSV-2 (1)
- HUVEC (1)
- Haplotypes (1)
- Head and neck Cancer (1)
- Health care (1)
- Health economics (1)
- Health services research [MeSH] (1)
- Healthcare worker (1)
- Hedgehog (1)
- Hemoglobin (1)
- Hemophilia A (1)
- Hemorrhagic shock (1)
- HepG2 (1)
- HepaRG cells (1)
- Hepatitis B (1)
- Hepatitis B infection (1)
- Hepatitis B vaccination (1)
- Hepatitis C (1)
- Hepatocytes (1)
- Hereditary angioedema (1)
- High-risk patient (1)
- Hippo signaling (1)
- Hippocampus (1)
- Histology (1)
- Hodgkin lymphoma (1)
- Holmes tremor (1)
- Homeostasis (1)
- Homicide (1)
- Hospitalizations (1)
- Host-directed therapies (1)
- Huh7 (1)
- Human (1)
- Human genetics (1)
- Human olfaction (1)
- Humeral fractures (1)
- Humerus (1)
- Hungary (1)
- Hydrocephalus (1)
- Hyperammonemic encephalopathy (1)
- Hypofractionated radiotherapy (1)
- Hypoxic responses (1)
- I-FABP (1)
- ICU (1)
- IGF (1)
- IL-15 (1)
- IL-1β (1)
- IL-21 (1)
- IL-27 cytokine (1)
- IL-33 (1)
- IL10R (1)
- ILUVIEN (1)
- IPEX (1)
- IPS e.max system (1)
- ISS (1)
- IUIS classification 2017 (1)
- IgE (1)
- IgG substitution therapy (1)
- IgGAM (1)
- Illumina (1)
- Image analysis (1)
- Imaging genetics (1)
- Immediate loading (1)
- Immediate placement (1)
- Immune Response (1)
- Immune cells (1)
- Immunoassays (1)
- Immunogenicity (1)
- Immunohistochemistry (1)
- Immunohistochemistry techniques (1)
- Immunomonitoring (1)
- Immunostaining (1)
- Immunosuppressive Agents (1)
- Implant-supported bars (1)
- In-line filtration (1)
- IncL (1)
- Incidence rate (1)
- Independent laboratories (1)
- Indirect-binding (1)
- Individual differences (1)
- Infarction (1)
- Infusion management (1)
- Insulin resistance (1)
- Integrated multimodal training (1)
- Intelligence (1)
- Intelligence tests (1)
- Intensive care (1)
- Intensive care units (1)
- Interleukin-17A (1)
- Interleukin-18 (1)
- Interleukin-18 binding protein (1)
- Interleukin-22 (1)
- Interleukin-22 binding protein (1)
- Interventional Trials (1)
- Interventional cardiology (1)
- Intracranial embolism (1)
- Intraoral scanners (1)
- Invasive fungal infection (1)
- Invasive fungal infections (1)
- Ipilimumab (1)
- Ireland (1)
- Iron deficiency (1)
- Iron deficiency anemia (1)
- JAK inhibition (1)
- Joint loading (1)
- KIF (1)
- KIF11 (1)
- Karyotypes (1)
- Ketogenic Diet (1)
- L-DOPA (1)
- LAMTOR2 (1)
- LC-NE system (1)
- LC3 I/II (1)
- LC–MS/MS (1)
- LDL (1)
- LM11A 31 (1)
- LN229 (1)
- LPP (1)
- LRBA (1)
- LSCC (1)
- LSD1 (1)
- LUT (1)
- Labor and delivery (1)
- Laboratory techniques and procedures (1)
- Lafora disease (1)
- Laminin (1)
- Laparoscopic fundoplication (1)
- Late Gadolinium Enhancement (LGE) (1)
- Late presentation (1)
- Left hemisphere (1)
- Leg alignment (1)
- Legs (1)
- Leistungsorientierte Mittelvergabe (1)
- Lesion (1)
- Lesions (1)
- Liver (1)
- Liver Transplantation (1)
- Liver cancer (1)
- Liver fibrosis (1)
- Liver-Related Complications (1)
- Lomentospora prolificans (1)
- Long noncoding RNA (1)
- Long term output (1)
- Long-term (1)
- Luciferase (1)
- Lumbar spine (1)
- Lyme disease (1)
- Lymph nodes (1)
- Lymphadenopathy (1)
- Lymphangioleiomyomatosis (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- Lymphomas (1)
- Lysosomal storage disease (1)
- MAIT cell (1)
- MALAT1 (1)
- MEG (1)
- MMP2 (1)
- MRI patterns of gliomas (1)
- MRSA (1)
- Machine-learning (1)
- Magnetic resonance imaging (MRI) (1)
- Malaria prevalence (1)
- MammaPrint (1)
- Mammaplasty (1)
- Markov model (1)
- Masquelet technique (1)
- Mass spectrometry (1)
- Mastectomy (1)
- Maxillary sinus (1)
- Mechanisms of disease (1)
- Meckel’s diverticulum (1)
- Medical education (1)
- Medical research (1)
- Medicine and health sciences (1)
- Membrane potential (1)
- Mesenchymal stem cell (1)
- Mesenchymal stromal cells (1)
- Metabolic syndrome (1)
- Metabolism (1)
- Metabolism, Inborn Errors (1)
- Metalloproteases (1)
- Metastasis (1)
- Metastatic castration-resistant prostate cancer (1)
- Metastatic tumors (1)
- Methacholine challenge test (1)
- Methicillin-resistant Staphylococcus aureus (1)
- MiSpEx Network (1)
- MicroRNAs (1)
- Microbiome (1)
- Microphones (1)
- Molecular profiling (1)
- Molecular signatures (1)
- Molecular subtype (1)
- Molecular subtypes (1)
- Monosaccharide Transport Proteins (1)
- Monte Carlo simulation (1)
- Morbidity (1)
- Morphogenesis (1)
- Motor control (1)
- Mouse models (1)
- Mucopolysaccharidoses (1)
- Multi-nucleated cardiomyocytes (1)
- Multidrug-resistant tuberculosis (1)
- Multinomial logistic regression (1)
- Multivariable analysis (1)
- NASH (1)
- NCH93 (1)
- NDR1 (1)
- NDUFAF8 (1)
- NEAT1 (1)
- NEAT2 (1)
- NGS (1)
- NK cell (1)
- NK cells (1)
- NK-92 (1)
- NKG2D (1)
- NKT cell (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMDAR subunit GluN2B (1)
- NOTCH1 (1)
- NPSR1 (1)
- NSAIDs (1)
- Nanopore (1)
- Native T1 (1)
- Native T1 mapping (1)
- Nav channel activity (1)
- Nav1.7 (1)
- Neonatal urea cycle disorders (1)
- Neonates (1)
- Network model (1)
- Neuro-ophthalmology (1)
- Neuroimaging (1)
- Neuroscience (1)
- Nivolumab (1)
- Non-REM sleep (1)
- Non-coding RNA (1)
- Non-invasive brain stimulation (1)
- Non-small cell lung cancer (1)
- Nonunion (1)
- Notch (1)
- Nox4 (1)
- Numerical simulation (1)
- OXA-48 (1)
- Occupational medicine (1)
- Olfactory diagnostics (1)
- One health (1)
- Opacity (1)
- Oposterior urethral valve (1)
- Opportunistic infections (1)
- Optical lenses (1)
- Oral Health Impact Profile (OHIP) (1)
- Oral and maxillofacial surgery (1)
- Oral anticoagulation (1)
- Oral implantology (1)
- Oral surgery (1)
- Organ dysfunction (1)
- Oroantral (1)
- Oroantral communication (1)
- Osteogenic differentiation (1)
- Osteoporosis diagnosis (1)
- PCP (1)
- PCSK9 protein (1)
- PEI (1)
- PF-06273340 (1)
- PGE2 (1)
- PID prevalence (1)
- PINK1 (1)
- PKCε (1)
- PLK1 inhibitors (1)
- PPARγ (1)
- Paediatric research (1)
- Pain (1)
- Pancreatic surgery (1)
- Pancreatoduodenectomy (1)
- Panic disorder (1)
- Parapneumonic pleural effusion (1)
- Parkinson disease (1)
- Parkinson’s disease (1)
- Particles (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Patient preferences (1)
- Pause (1)
- Pediatric patients (1)
- Pediatrics (1)
- Pentaglobin (1)
- Peritonitis (1)
- Personalised medicine (1)
- Pharm-fMRI (1)
- Pharmacometrics (1)
- Philadelphia chromosome-positive acute leukemia (1)
- Phylogenetic analysis (1)
- Platelet-rich fibrin (1)
- Platelets (1)
- Platzierung (1)
- Plerixafor (1)
- Pleural empyema (1)
- Pneumocystis jirovecii (1)
- Pneumonia (1)
- Polyunsaturated fatty acids (1)
- Ponatinib (1)
- Portal veins (1)
- Portugal (1)
- Posaconazole serum level (1)
- Positron-emission tomography (1)
- Post treatment (1)
- Precision (1)
- Precision oncology (1)
- Prenatal ultrasonographic detection rate (1)
- Preoperative diagnostics (1)
- Prevalence (1)
- Prevention (1)
- Primary care (1)
- Primary cilium (1)
- Primary health care [MeSH] (1)
- Prisoners (1)
- Prisons (1)
- Profilometry (1)
- Prognostic biomarker (1)
- Prophylaxis (1)
- Prostaglandin (1)
- Prostate-specific membrane antigen (1)
- Prostatic neoplasms (1)
- Protease inhibitor therapy (1)
- Protein translation (1)
- Proteomics (1)
- Proteostasis (1)
- Proton density (1)
- Psychometric evaluation (1)
- Psychometrics (1)
- Quality of care (1)
- Quantitative MRI (1)
- Questionnaires (1)
- REMS (1)
- RNA binding proteins (1)
- RNA extraction (1)
- RNA isolation (1)
- RNAi (1)
- RTS (1)
- RUCAM (1)
- Radiotherapy (1)
- Rare Diseases (1)
- Re-injury (1)
- Reaction time (1)
- Reactive oxygen species (1)
- Real-world evidence (1)
- Recurrence (1)
- Red blood cell transfusion (1)
- Refractory ALL (1)
- Regenerative medicine (1)
- Regression analysis (1)
- Regulatory T cells (1)
- Rehabilitation (1)
- Relapsed ALL (1)
- Relaxometry (1)
- Renal system (1)
- Reproducibility (1)
- Research trends (1)
- Retina (1)
- Retro-IDEAL (1)
- Return to play (1)
- Return to sports (1)
- Rhabdomyosarcoma (1)
- Rheumatoid arthritis (1)
- Rheumatology (1)
- Rho/Rho-kinase (1)
- Ribosomes (1)
- Risk assessment (1)
- Risk prediction (1)
- Roe deer (1)
- Roughness (1)
- Roussel Uclaf Causality Assessment Method (1)
- Roussel Uclaf Causality Assessment Method (RUCAM) (1)
- S1P (1)
- S1PR1 (1)
- SCA34 (1)
- SCA38 (1)
- SHH (1)
- SILAC (1)
- ST2L (1)
- STAT3 (1)
- SUMO1-3 (1)
- SUMOylation (1)
- SUV (1)
- SW480 cells (1)
- SWATH (1)
- Saccades (1)
- Saccadometry (1)
- Safety (1)
- Salivary gland diseases (1)
- Salvage therapy (1)
- Sarcopenia (1)
- Scanner models (1)
- Scedosporium spp. (1)
- Screening (1)
- Screening guidelines (1)
- Secondary prevention (1)
- Seizure (1)
- Sensory perception (1)
- Sensory systems (1)
- Sequence motif analysis (1)
- Serine proteases (1)
- Serotype 3 (1)
- Severe bacterial infection (1)
- Sex differences (1)
- Signal transduction (1)
- Single-cell RNA-sequencing (1)
- Small RNA analysis (1)
- Smooth muscle cells (1)
- Social epidemiology (1)
- Social health determinants (1)
- Social participation (1)
- Somatization (1)
- Specimen preparation and treatment (1)
- Speech signal processing (1)
- Splanchnic Hemodynamics (1)
- Staphylococcus aureus (1)
- Steatosis (1)
- Stem cell (1)
- Stem cells (1)
- Stenosis (1)
- Sterblichkeit (1)
- Steroid (1)
- Streptococcus pneumoniae (1)
- Stress (1)
- Stress and resilience (1)
- Striatum (1)
- Stromal cell (1)
- Structured reporting (1)
- Subarachnoid hemorrhage (1)
- Subcutaneous (1)
- Surface (1)
- Surgical education (1)
- Survival (1)
- Sustained virological response (SVR) (1)
- Systematic reviews (1)
- Systemic lupus erythematosus (1)
- Systems biology (1)
- Systems medicine (1)
- T cell (1)
- T cell receptors (1)
- TBK1 (1)
- TCR signaling cascade (1)
- TEER (1)
- TF-complexes (1)
- TGF-β1 (1)
- TILs (1)
- TIMP2 (1)
- TKI (1)
- TMEM126B (1)
- TMS (1)
- TMT (1)
- TP53-induced glycolysis and apoptosis regulator (1)
- TRIM25 (1)
- Tacrolimus (1)
- Target identification (1)
- Targeted therapies (1)
- Taxane (1)
- Tea (1)
- Telomere length (1)
- Telomeres (1)
- Texture analysis (1)
- Theft (1)
- Therapy (1)
- Therapy response (1)
- Thoracic trauma (1)
- Thromboembolism (1)
- Thrombosis (1)
- Thrombotic microangiopathy (1)
- Thrombotic thrombocytopenic purpura (1)
- Thromboxane (1)
- Thymocytes (1)
- Thymus (1)
- Tick (1)
- Time in therapeutic range (TTR) (1)
- Time to treatment failure (1)
- Tissue microarray (TMA) (1)
- Tools and ressources (1)
- Total hip replacement (1)
- Toxicity (1)
- Transcription Factors (1)
- Transcriptional control (1)
- Transgender (1)
- Translation initiation (1)
- Translational (1)
- Translational research (1)
- Trees (1)
- Treg cell (1)
- Trimeric autotransporter adhesins (1)
- Trk (1)
- TrkC (1)
- Trousseau’s syndrome (1)
- Trueness (1)
- Tularemia (1)
- Tumor heterogeneity (1)
- Tumour immunology (1)
- U-87MG (1)
- Ulcerative colitis (1)
- Ultrasonography (1)
- Ultrasound (1)
- Umbilical cord (1)
- Unilateral hip osteoarthritis (1)
- United States (1)
- Uveal melanoma (1)
- VARGADO (1)
- VDR (1)
- VEGFA (1)
- VGAT-ChR2 (1)
- VISTA (1)
- Vaccination (1)
- Vaccine breakthrough (1)
- Vacuoles (1)
- Validation (1)
- Vascular disease (1)
- Vasculogenesis (1)
- Veins (1)
- Video-oculography (1)
- Viral load (1)
- Virtual implant planning (1)
- Virtual patients (1)
- Virulence (1)
- Visual acuity (1)
- Visual impairments (1)
- Visual system (1)
- Vitamin K antagonists (1)
- Vitreous opacity (1)
- Vmem (1)
- Volume overload (1)
- Voriconazole (1)
- WNT (1)
- WT1 (1)
- Westphal-Paradigm (1)
- White blood cells (1)
- WoMo score (1)
- Working memory (1)
- Wound healing (1)
- Zebrafish (1)
- Zika virus (1)
- Zoonosis (1)
- abuse (1)
- accidents (1)
- acid sphingomyelinase (ASMase; Smpd1) (1)
- acneiform skin toxicity (1)
- acoustic radiation force impulse imaging (1)
- acute decompensation (1)
- acute liver failure (1)
- acute lung injury (1)
- acute lung injury (ALI) (1)
- acute-on-chronic liver failure (1)
- adalimumab (1)
- adeno-associated virus (1)
- adeno‐associated virus (1)
- adherence (1)
- adhesion (1)
- adipocytes (1)
- adiponectin (1)
- adipose tissue (1)
- adipose-derived mesenchymal stem cells (1)
- adipose-derived stem cells (1)
- adolescents (1)
- adoptive cancer immunotherapy (1)
- adrenal insuffciency (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adverse effects (1)
- ageing (1)
- aging (1)
- air flow (1)
- air pollution (1)
- airborne bacteria (1)
- albumin (1)
- alcohol (1)
- alcohol dehydrogenase (ADH) (1)
- alcohol metabolism (1)
- alcoholic liver disease (1)
- alcoholic liver injury (1)
- alloHSCT (1)
- allogeneic stem cell transplantation (1)
- alpha receptor (1)
- alpha-synuclein (1)
- amisulpride (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaemia (1)
- anal cancer (1)
- anaplastic large cell lymphoma (1)
- angio-immunogenic switch (1)
- animal models (1)
- anti-cancer therapy (1)
- antibodies (1)
- anticonvulsant (1)
- antiepileptic drug (1)
- antifibrotic therapy (1)
- antifungal therapy (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antiviral drugs (1)
- apigenin (1)
- aromatics (1)
- arthritis (1)
- artificial intelligence (1)
- ascites (1)
- associative memory (1)
- astrocytoma (1)
- ataxia score (1)
- ataxia telangiectasia (1)
- atherosclerosis (1)
- atrial fibrillation (1)
- attention modulation (1)
- attention-deficit/hyperactivity disorder (1)
- attention-deficit/hyperactivitydisorder (1)
- attractiveness (1)
- augmentation (1)
- authentication (1)
- autism spectrum disorder (1)
- autologous stem cell transplantation (1)
- automated patch-clamp (1)
- azaindole (1)
- bacteria (1)
- basic mechanisms (1)
- basonuclin 2 (1)
- beam quality correction factors (1)
- belimumab (1)
- beta‐trace protein (1)
- bevacizumab (1)
- binary search procedure (1)
- bioacoustics (1)
- bioactivity (1)
- biofilm (1)
- biological treatments (1)
- biologics (1)
- biomarkers (1)
- biopsy (1)
- bipolar disorder (1)
- bladder cancer (1)
- bladder dose (1)
- blood flow restriction (1)
- bmal1 (1)
- body mass index (1)
- bone chips (1)
- bone damage (1)
- bone healing (1)
- bone loss (1)
- bone marrow derived mononuclear cells (1)
- bone morphogenetic proteins (BMPs) (1)
- bone regeneration (1)
- bone‐screw (1)
- bone–implant interface (1)
- borrelia (1)
- borrelia mayonii (1)
- brachytherapy (1)
- brain phosphorylome (1)
- brain states (1)
- bronchial allergen provocation (1)
- cadherin (1)
- calcitriol (1)
- callous-unemotional traits (1)
- calprotectin (1)
- calretinin (1)
- calretinin-knock out (1)
- cancer cell metabolism (1)
- cancer patients (1)
- cancer stem cells (1)
- cancer treatment (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- cannabis (1)
- cap-dependent translation (1)
- capsaicin (1)
- car indoor (1)
- carbapenemases (1)
- carbon oxides (COx) (1)
- cardiac myocytes (1)
- cardiomegaly (1)
- cardiovascular (1)
- cardiovascular management (1)
- case reports (1)
- caspase 8 (1)
- caspase-8 (1)
- catheter removal (1)
- cdk (1)
- cell adhesion (1)
- cell biology (1)
- cell cycle arrest (1)
- cell cycling (1)
- cell death (1)
- cell growth (1)
- cell line (1)
- cell motility (1)
- cell survival mechanisms (1)
- cell therapy (1)
- centrifugation (1)
- ceramide (1)
- ceramide synthase (CERS2/CERS1) (1)
- cerebral radiation necrosis (1)
- cerebrovascular disease (1)
- ceritinib (1)
- cervical cancer (1)
- channelrhodopsin (1)
- characterization (1)
- checkpoint proteins (1)
- chemokine receptors (1)
- chemoradiotherapy (1)
- chemoresistance (1)
- chemotherapy (1)
- chemotherapy resistance (1)
- chest injury (1)
- chest trauma (1)
- child (1)
- childhood abuse (1)
- children (1)
- chimeric antigen receptor (1)
- chronic myeloid leukemia (1)
- chronobiology (1)
- cigarette strength (1)
- cigarettes (1)
- circadian rhythm (1)
- circulating miRNA (1)
- classical conditioning (1)
- classification of bone defects (1)
- clinical immunology (1)
- clinical research (1)
- clinical study (1)
- clinical trial (1)
- cloacae (1)
- clock genes (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- cochlear implant (1)
- cognitive deficits (1)
- cognitive functions (1)
- collagen (1)
- collagen I (1)
- collagen degradation marker (1)
- collateral sprouting (1)
- colon carcinoma cells (1)
- colorectal carcinoma (1)
- combination treatment (1)
- common variant (1)
- complex I (1)
- complex I deficiency (1)
- compliance (1)
- computational models (1)
- computational neuroscience (1)
- computational techniques (1)
- computational virology (1)
- concordance (1)
- conduct disorder (1)
- connective tissue graft (1)
- consensus paper (1)
- convolution neural network (1)
- coordination (1)
- copeptin (1)
- cornea donor (1)
- coronary artery bypass graft surgery (1)
- cortical malformation (1)
- cortical thickness (1)
- cortisol (1)
- cost-effective (1)
- courting behavior (1)
- critical size defect (1)
- critically ill patients (1)
- cross-sectional study (1)
- cryopreservation (1)
- cyclin D1 (1)
- cyclins (1)
- cyclosporine (1)
- cystatin C (1)
- cystic fibrosis (1)
- cytochrome P450 2E1 (1)
- cytokine, angiogenesis (1)
- cytotoxic T cells (1)
- death (1)
- death receptor (1)
- deep neural network (1)
- defect configuration (1)
- delayed wound healing (1)
- dental implants (1)
- depression (1)
- depressive symptoms (1)
- desmoplastic small round cell tumor (1)
- detoxification (1)
- diabetic neuropathy (1)
- diffusion tensor imaging (1)
- diffusion tensor imaging (DTI) (1)
- dimethylfumarate (1)
- direct-acting antivirals (DAAs) (1)
- directed disulfide bond formation (1)
- discoidin domain-containing receptor (1)
- discomfort/pain (1)
- disease-free survival (1)
- dissemination (1)
- distal pronephric outlet obstruction (1)
- distress (1)
- docetaxel (1)
- dopamine (1)
- dosimetry (1)
- double inversion recovery (DIR) (1)
- doxorubicin (1)
- drilling tool design (1)
- drug induced liver injury (1)
- drug metabolism and distribution (1)
- drug release (1)
- drug resistance (1)
- drug targets (1)
- drug therapy (1)
- drug-induced liver injury (1)
- drug-induced liver injury (DILI) (1)
- dual task (1)
- dynamic 18F-FDG PET/CT (1)
- early continence (1)
- early loss (1)
- early tumor stages (1)
- economy (1)
- edema (1)
- ejection fraction (EF) (1)
- elderly patients (1)
- electrical stimulation (1)
- electrocardiography (1)
- electron transport chain (1)
- eltrombopag (1)
- emergency care (1)
- emergent self-organizing maps (1)
- emotional information processing (1)
- empowerment (1)
- endometriosis (1)
- endophytes (1)
- endoplasmic reticulum (1)
- endothelial cell (1)
- endothelial cells (1)
- endothelial to mesenchymal transition (1)
- endotoxins (1)
- entorhinal cortex lesion (1)
- envelope technique (1)
- eosinophil cationic protein (1)
- eosinophils (1)
- epigenetic (1)
- epigenetics (1)
- epigenome (1)
- euthymic (1)
- evaluation (1)
- evaluation practice (1)
- everolimus (1)
- evoked response (1)
- evolution (1)
- ex vivo expansion (1)
- excess fluid volume (1)
- executive function (1)
- exercise training (1)
- exosomes (1)
- expression studies (1)
- extracellular vesicles (1)
- eye tracking (1)
- face-name association task (1)
- factor H (1)
- factor IX (1)
- factor VIII (1)
- fat (1)
- fatty acid elongase (Elovl1/4/5) (1)
- fatty acids (1)
- feedback (1)
- femoral artery ligation (1)
- fibroblasts (1)
- fibrocytes (1)
- fibrosis (1)
- fibrotest (1)
- fidaxomicin (1)
- fitness (1)
- fixed partial dentures (1)
- fizička aktivnost; (1)
- flavivirus entry factor (1)
- flow cytometry (1)
- fluorescent dye (1)
- focal adhesion (1)
- focal cortical dysplasia (FCD) (1)
- fresh frozen plasma (1)
- full-contour crown restorations (1)
- functional connectivity (1)
- functional genetics (1)
- fungal pathogens (1)
- fungi (1)
- fusion (1)
- gRNA library (1)
- gadolinium‐based contrast agent (1)
- gel spacer injection (1)
- gender (1)
- gender dysphoria (1)
- gender-affirming hormone therapy (1)
- gene expression (1)
- gene expression analysis (1)
- gene regulation (1)
- gene signature (1)
- gene therapy (1)
- genetics (1)
- genetics and genomics (1)
- gene×environment interactions (1)
- genome-wide (1)
- glecaprevir (1)
- glial activation (1)
- glioblastoma (GBM) (1)
- global diversity (1)
- glutamate (1)
- glutamine (1)
- gossypol (1)
- graft-versus host (1)
- granulocytecolony stimulating factor (1)
- granuloma (1)
- gray‐white matter blurring (1)
- growth (1)
- growth hormone (1)
- growth inhibition (1)
- gut microbiota (1)
- haemophilia (1)
- head and neck cancer (1)
- head-to-head (1)
- health apps (1)
- health‐related quality of life (1)
- heart (1)
- heart rate (1)
- heat (1)
- hematopoiesis (1)
- hematopoietic stem cell mobilization (1)
- hematopoietic stem cells (1)
- hematopoietic stress (1)
- hepatic osteodystrophy (1)
- hepatic phenotype (1)
- hepatic steatosis (1)
- hepatitis B (1)
- hepatitis B virus (1)
- hepatitis C virus (HCV) (1)
- herb induced liver injury (1)
- hereditary angioedema (1)
- high molecular weight plasticizer (1)
- high-dimensional data sets (1)
- high-dose-rate interstitial brachytherapy (1)
- high-energy photon and proton radiation (1)
- hippocampus (1)
- histone deacetylases (HDACs) (1)
- hospital exemption (1)
- host cell interaction (1)
- host cell response (1)
- host immune response (1)
- host-directed therapies (1)
- hostpathogen interaction (1)
- human Natural Killer cell (1)
- human antigen R (HuR) (1)
- human biology and medicine (1)
- human cytomegalovirus (1)
- human immunodeficiency virus (1)
- human skin graft (1)
- humectant agents (1)
- hygienic hand disinfection (1)
- hygienische Händedesinfektion (1)
- hypertension and anti-hypertensive treatment (1)
- hypoparathyroidism (1)
- hypoxia-inducible factor (1)
- idiopathic dystonia (1)
- idiopathic pulmonary fibrosis (1)
- idiosyncratic DILI (1)
- ifenprodil (1)
- illness experiences (1)
- image analysis (1)
- immune deficiency (1)
- immune dysregulation (1)
- immune landscape (1)
- immune responses (1)
- immune system (1)
- immune-checkpoint inhibition (1)
- immunity (1)
- immunoglobulin superfamily (1)
- immunological research (1)
- immunology and infectious diseases (1)
- immunosuppressive agent (1)
- immunosuppressive drug (1)
- implant movement (1)
- implant stability (1)
- in silico simulation (1)
- in vivo micro‐CT (1)
- indication (1)
- indomethacin (1)
- induced membrane (1)
- infiltration (1)
- inflammatory bowel disease (1)
- information transfer (1)
- inhibitory interneurons (1)
- insect herbivory (1)
- insertion (1)
- insula (1)
- integrated stress response (1)
- intensive care unit (1)
- interferon gamma (1)
- internal ribosomal entry site (IRES) (1)
- interstitial lung disease (1)
- intestinal barrier (1)
- intrinsic DILI (1)
- intrinsic apoptosis (1)
- invasive fungal disease (1)
- ionotropic glutamate receptors (1)
- iron chelation (1)
- iron chelator (1)
- iron chelators (1)
- iron deficiency (1)
- iron homeostasis (1)
- iron metabolism (1)
- irradiation (1)
- isogenic (1)
- ixekizumab (1)
- junctional adhesion molecule (1)
- juvenile myoclonic epilepsy (1)
- kidney transplantation (1)
- kinesin (1)
- lapatinib (1)
- latent tuberculosis infection (1)
- left ventricular function (1)
- legal gender reassignment (1)
- leukocytes (1)
- leukodystrophy (1)
- lifelong learning (1)
- light transmission aggregometry (1)
- liminality (1)
- linoleic acid metabolites (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipids (1)
- lipids inflammatory pain (1)
- lipocalin-2 (1)
- lipopolyplex (1)
- lipopolysaccharide (1)
- lipoxygenase (1)
- liquid-PRF (1)
- liver (1)
- liver adaption (1)
- liver cancer (1)
- liver cell lines (1)
- liver diseases (1)
- liver fibrosis (1)
- liver injury (1)
- liver metabolism (1)
- local control (1)
- long-term distress (1)
- longitudinal relaxation time T1 (1)
- low speed centrifugation concept (1)
- low-back pain (1)
- low-cost medication (1)
- lower urinary tract obstruction (1)
- luteolin (1)
- lyme disease (1)
- lymphangiogenesis (1)
- mGluR3 (1)
- mGluR5 (1)
- mRNA active cancer immunotherapy (1)
- mRNA decay (1)
- mRNA stability (1)
- mTOR inhibition (1)
- mTORC1 (1)
- machine learning (1)
- machine-learning (1)
- maintenance therapy (1)
- major adverse cardiac events (1)
- major depressive disorder (1)
- malignant glioma (1)
- mammary cancer (1)
- mammary carcinoma (1)
- marathon (1)
- maraton (1)
- mass spectrometry (1)
- massive weight loss (1)
- massively parallel multigrid solvers (1)
- mathematical models of viral RNA cycle (1)
- matrix metalloproteinase (1)
- mechanistic target of rapamycin (mTOR) (1)
- medial thigh lift (1)
- medical error (1)
- medulloblastoma resection (1)
- memantine (1)
- memory (1)
- meningioma (1)
- merkel cell carcinoma (1)
- mesenchymal stromal cell (1)
- mesenchymal stromal/stem cells (1)
- metabolites (1)
- metastasis (1)
- metastates (1)
- metformin (1)
- methylation profiling (1)
- miR (1)
- miR-143-3p (1)
- miR-181 (1)
- miR-375 (1)
- mice (1)
- microbiome (1)
- microdosing (1)
- microglia (1)
- microsomal ethanol-oxidizing system (MEOS) (1)
- microtubular cytoskeleton (1)
- microtubule disruptors (1)
- mild cognitive impairment (1)
- mitochondrial bioenergetics and glycolysis (1)
- mitochondrial disease (1)
- mitophagy (1)
- mobile phone apps (1)
- mobile tongue cancer (1)
- modeling (1)
- molecular diagnosis (1)
- molecular marker (1)
- montelukast (1)
- motility (1)
- mouse (1)
- mouse model (1)
- movement disorders (1)
- mpMRI (1)
- mtor (1)
- mucosal inflammation (1)
- mucositis (1)
- multidisciplinary pain treatment (1)
- multimorbidity (1)
- multiplex immunofluorescence (1)
- musician (1)
- mutations (1)
- mycophenolate mofetil [MMF] (1)
- myeloid cells (1)
- myocardial infarction (1)
- myocardial injury (1)
- myocardium (1)
- myogenic tone (1)
- myogenic vasoconstriction (1)
- myositis (1)
- nadp (1)
- nanoparticles (1)
- natural killer cells (1)
- nematophin (1)
- neoplasms (1)
- nerve-sparing (1)
- network analysis (1)
- network neuroscience (1)
- neural network (1)
- neuroblastoma (1)
- neurodegeneration (1)
- neurodevelopmental disorders (1)
- neuronal silencing (1)
- neurons (1)
- neuropathic pain (1)
- neuropsychological impairment (1)
- neurotrophins (1)
- neutral ceramidase (Asah2) (1)
- neutral sphingomyelinase (Smpd3) (1)
- new miRNA functions (1)
- nintedanib (1)
- nitrogen oxides (NOx) (1)
- nocardia (1)
- nocardiosis (1)
- nodular sclerosis (1)
- non-classical adhesion molecule (1)
- non-invasive fibrosis assessment (1)
- non-sensory bias (1)
- non-small-cell lung cancer (1)
- noradrenaline (1)
- norepinephrine (1)
- nutrient deprivation (1)
- observational cohort study (1)
- oksidacioni stres (1)
- older patients (1)
- olivo-ponto-cerebellar atrophy (OPCA) (1)
- oncogene (1)
- oncolytic virotherapy (1)
- optogenetics (1)
- organ dysfunction (1)
- organ failure (1)
- organisation of health services (1)
- organophosphate flame retardants (OFR) (1)
- orthodontic mini‐implant (1)
- oscillator (1)
- osteoarthritis (1)
- osteogenesis (1)
- osteopenia (1)
- osteotomy (1)
- outcome (1)
- overall survival (1)
- overweight (1)
- oxidative stress (1)
- p14 (1)
- p62 (1)
- p75 (1)
- pack-years (PY) (1)
- pain (1)
- pain management (1)
- pain target (1)
- palatal tremor (1)
- particulate matter (PM) (1)
- passive reading paradigm (1)
- patent (1)
- patient (1)
- patient and public involvement (1)
- patient blood management (1)
- patient perspective (1)
- patient preference (1)
- patient safety (1)
- patients' experience (1)
- patient‐centred outcomes (1)
- pazopanib (1)
- pediatric patients (1)
- pedicle screws (1)
- peficitinib (1)
- perforant path transection (1)
- performance evaluation (1)
- performance-based funding allocation (1)
- perio-prosthetic joint infection (1)
- periodontal probing, (1)
- periodontitis (1)
- perirenal (1)
- peri‐implant lesions (1)
- peri‐implant probing (1)
- peri‐implantitis (1)
- pharmaco-fMRI (1)
- pharmacodynamics (1)
- pharmacogenetics (1)
- pharmacoresistance (1)
- phase 3 study (1)
- phosphatases (1)
- phylogenetic analysis (1)
- physical activity (1)
- pibrentasvir (1)
- pitch perception (1)
- placement (1)
- plant growth (1)
- plant resistance (1)
- plant-insect interactions (1)
- plasmid (1)
- plastic (1)
- plasticity (1)
- platelet aggregation (1)
- platelet lysate (1)
- platelet rich plasma (1)
- platelet-rich fibrin (1)
- platelets (1)
- platform switching (1)
- pleuropericarditis (1)
- point shear wave elastography (1)
- polo-like kinase 1 (1)
- polo-like kinase 3 (1)
- poly(lactic-co-glycolic acid) (PLGA) (1)
- polyethylenimine (1)
- polyomavirus (MCPyV) (1)
- polypharmacology (1)
- population dynamics (1)
- post-translational modifications (PTMs) (1)
- posterior fossa masses (1)
- postmortem blood samples (1)
- posttraumatic stress disorder (1)
- post‐traumatic stress disorder (1)
- power dynamics (1)
- pranlukast (1)
- pre-clinical models (1)
- preeclampsia (1)
- prefrontal cortex (1)
- preoperative anaemia management (1)
- pressure cycling technology (1)
- pressure ulcer treatment (1)
- preterm birth (1)
- primary cilium (1)
- primary immunodeficiency (1)
- primary immunodeficiency (PID) (1)
- progestin (1)
- prognosis (1)
- progressive myoclonus epilepsy (1)
- pronephric development (1)
- prophylaxis (1)
- prospective studies (1)
- protein tagging (1)
- proto-oncogene proteins c-akt (1)
- proton density (1)
- proton pump inhibitors (1)
- psoriatic arthritis (1)
- psychological distress (1)
- psychophysiology (1)
- psychosocial stress (1)
- public health (1)
- pulmonary nocardiosis (1)
- pulse labeling (1)
- pulse-spreading harmonic complex (1)
- pupil dilation (1)
- pupillary reactivity (1)
- qualitative research (1)
- quality assurance (1)
- quantitative T1 mapping (1)
- quantitative T1‐difference maps (1)
- radiation therapy (1)
- radioimmunotherpay (1)
- radioresponse (1)
- radixin (1)
- randomized (1)
- rare variant (1)
- re-emerging virus (1)
- re-osseointegration (1)
- reactivation (1)
- reactive oxygen species (ROS) (1)
- reaktivne vrste kiseonika (1)
- real-world data (1)
- realistic geometries (1)
- recertification (1)
- recommendations (1)
- recurrent laryngeal nerve palsy (1)
- refractory aGvHD (1)
- regeneration (1)
- registry for primary immunodeficiency (1)
- regorafenib (1)
- regorafenib csf concentration (1)
- relaxometry (1)
- remote monitoring (1)
- removal (1)
- renal cell cancer (1)
- renin-angiotensin system (1)
- reorganization (1)
- repeat DMEK (1)
- reservoir computing (1)
- resistance (1)
- resistance-associated substitutions (RAS) (1)
- resting-state fMRI (1)
- resting‐state (1)
- retrospective (1)
- revalidation (1)
- revision surgery (1)
- rhabdomyosarcoma (1)
- rhabdomyosarcomas (1)
- rheumatoid arthritis (1)
- ribavirin (1)
- right ventricular function (1)
- risk factor progression (1)
- risk genes (1)
- risk management (1)
- root coverage (1)
- rosetting T cells (1)
- rub-in technique (1)
- running wheel (1)
- sRNA (1)
- sRNA tool (1)
- safety (1)
- scaffold size (1)
- schizophrenia (1)
- schizophrenia spectrum (1)
- sclerostin (1)
- scoping review (1)
- screening test (1)
- screw augmentation (1)
- screw loosening (1)
- second-hand smoke (1)
- secretion (1)
- seed germination (1)
- segmentation (1)
- seizure (1)
- selectin (1)
- sensorimotor exercise training (1)
- sensory neuropathy (1)
- sensory processing (1)
- serine palmitoyltransferase 2 (Sptlc2) (1)
- serologic screening (1)
- serositis (1)
- serum albumin deficiency (1)
- severe vitamin D deficiency (1)
- sex differences (1)
- sexually transmitted diseases (1)
- sexually transmitted infection (1)
- sham (1)
- shortening of treatment (1)
- shunt (1)
- siRNA analysis (1)
- siRNA delivery (1)
- siRNA quantification (1)
- siRNA/RNAi (1)
- signature (1)
- silicone device (1)
- simulation (1)
- simulation training (1)
- single-sided deafness (1)
- sinus rhythm (1)
- six-step technique (1)
- smoking (1)
- sofosbuvir (1)
- soft tissue sarcoma (1)
- soft tissue sarcoma (STS) (1)
- soluble epoxide hydrolase (1)
- somatic mutations (1)
- sonic hedgehog signaling (1)
- sound-induced flash illusion (1)
- spatial specificity (1)
- spectroscopy (1)
- sphingolipid (1)
- spider toxin (1)
- spiking neural networks (1)
- spinal fusion (1)
- spirochete (1)
- spirochetes (1)
- starvation (1)
- stem cell transplantation (1)
- steroid-resistant aGvHD (1)
- stimulation (1)
- stopping rule (1)
- stratification (1)
- strength training (1)
- stress response (1)
- stroke (1)
- structural covariance (1)
- subcutaneous fat (1)
- subjunctivity (1)
- success rate (1)
- sulfasalazine (1)
- suplementacija (1)
- supplementation (1)
- support vector machines (1)
- surveillance (1)
- survival (1)
- survival rate (1)
- synaptic signaling (1)
- synovial fibroblast (1)
- systemic inflammation (1)
- t-distributed stochastic neighbor embedding (1)
- tDCS (1)
- tacrolimus (1)
- target variability (1)
- telemedicine (1)
- telmisartan (1)
- temozolomide (1)
- temsirolimus (1)
- temsirolimus-resistance (1)
- thighplasty (1)
- thrombocyte dysfunction (1)
- thrombocyte function (1)
- thrombolysis (tPA) (1)
- thrombopietin receptor agonist (1)
- thrombospondin-4 (1)
- thymus (1)
- thyroid resection (1)
- tissue Doppler imaging (1)
- tissue engineering (1)
- tolerance (1)
- tongue edema (1)
- topographic maps (1)
- total joint arthroplasty (TJA) (1)
- trafficking (1)
- transcriptional profiling (1)
- transcriptome (1)
- transdifferentiation (1)
- transforming growth factor beta (1)
- transforming growth factor beta (TGF-β) (1)
- transient elastography (1)
- transient receptor potential channels (1)
- translation (1)
- transmission and vector control (1)
- transsexualism (1)
- trastuzumab (1)
- trophoblastic cell lines (1)
- trophoblasts (1)
- troponin (1)
- tumor (1)
- tumor growth (1)
- tumor immune evasion (1)
- tumor microenviroment (1)
- tumor progression (1)
- tumor proliferation (1)
- tumor‐associated macrophages (1)
- two-tissue compartment model (1)
- tyrosine kinase inhibitor (1)
- ulcerative colitis (1)
- uncertainty (1)
- unfolded protein response (1)
- ustekinumab (1)
- uterine cervical cancer (1)
- vaccine (1)
- valproic acid (1)
- vancomycin (1)
- vascular complications (1)
- vascular disease (1)
- vascular dysfunction and inflammation (1)
- vascular smooth muscle (1)
- velpatasvir (1)
- ventral tegmental area (1)
- vesicovaginal septum (1)
- viability (1)
- viral dynamics (1)
- viral gene transfer (1)
- virulence (1)
- vitamin D supplementation (1)
- vitamin D target genes (1)
- vitamin Dmetabolism (1)
- voice (1)
- volatile organic compounds (VOC) (1)
- voluntary training (1)
- voxilaprevir (1)
- within-host viral modeling (1)
- women (1)
- words (1)
- work-life balance (1)
- working conditions (1)
- wound healing (1)
- yellow fever virus (1)
- yellow fever virus tropism (1)
- zafirlukast (1)
- zebrafish (1)
- zirconia (1)
- Überwachung (1)
- β-catenin (1)
- β-lactamases (1)
- γδT cell (1)
- гепатит С (1)
- правила прекращения лечения (1)
- противовирусные препараты прямого действия (ПППД) (1)
- сокращение лечения (1)
- устойчивый вирусологический ответ (УВО) (1)
- flow cytometry (1)
Institute
- Medizin (500) (remove)
Background: Congenital duodenal obstruction (CDO) can be complete (CCDO) or incomplete (ICDO). To date there is no outcome analysis available that compares both subtypes.
Aim: To quantify and compare the association between CCDO and ICDO with outcome parameters.
Methods: We retrospectively reviewed all patients who underwent operative repair of CCDO or ICDO in our tertiary care institution between January 2004 and January 2017. The demographics, clinical presentation, preoperative diagnostics and postoperative outcomes of 50 patients were compared between CCDO (n = 27; atresia type 1-3, annular pancreas) and ICDO (n = 23; annular pancreas, web, Ladd´s bands).
Results: In total, 50 patients who underwent CDO repair were enrolled and followed for a median of 5.2 and 3.9 years (CCDO and ICDO, resp.). CCDO was associated with a significantly higher prenatal ultrasonographic detection rate (88% versus 4%; CCDO vs ICDO, P < 0.01), lower gestational age at birth, lower age and weight at operation, higher rate of associated congenital heart disease (CHD), more extensive preoperative radiologic diagnostics, higher morbidity according to Clavien-Dindo classification and comprehensive complication index (all P ≤ 0.01). The subgroup analysis of patients without CHD and prematurity showed a longer time from operation to the initiation of enteral feeds in the CCDO group (P < 0.01).
Conclusion: CCDO and ICDO differ with regard to prenatal detection rate, gestational age, age and weight at operation, rate of associated CHD, preoperative diagnostics and morbidity. The degree of CDO in mature patients without CHD influences the postoperative initiation of enteral feeding.
Apigenin (4′,5,7-trihydroxyflavone) (Api) is an important component of the human diet, being distributed in a wide number of fruits, vegetables and herbs with the most important sources being represented by chamomile, celery, celeriac and parsley. This study was designed for a comprehensive evaluation of Api as an antiproliferative, proapoptotic, antiangiogenic and immunomodulatory phytocompound. In the set experimental conditions, Api presents antiproliferative activity against the A375 human melanoma cell line, a G2/M arrest of the cell cycle and cytotoxic events as revealed by the lactate dehydrogenase release. Caspase 3 activity was inversely proportional to the Api tested doses, namely 30 μM and 60 μM. Phenomena of early apoptosis, late apoptosis and necrosis following incubation with Api were detected by Annexin V-PI double staining. The flavone interfered with the mitochondrial respiration by modulating both glycolytic and mitochondrial pathways for ATP production. The metabolic activity of human dendritic cells (DCs) under LPS-activation was clearly attenuated by stimulation with high concentrations of Api. Il-6 and IL-10 secretion was almost completely blocked while TNF alpha secretion was reduced by about 60%. Api elicited antiangiogenic properties in a dose-dependent manner. Both concentrations of Api influenced tumour cell growth and migration, inducing a limited tumour area inside the application ring, associated with a low number of capillaries.
Objectives: There is sparse information on the safety of early primary discharge from the emergency department (ED) after rule-out of myocardial infarction in suspected acute coronary syndrome (ACS). This prospective registry aimed to confirm randomised study results in patients at low-to-intermediate risk, with a broader spectrum of symptoms, across different institutional standards and with a range of local troponin assays including high-sensitivity cTn (hs-cTn), cardiac troponin (cTn) and point-of-care troponin (POC Tn).
Design: Prospective, multicentre European registry.
Setting: 18 emergency departments in nine European countries (Germany, Austria, Switzerland, France, Spain, UK, Turkey, Lithuania and Hungary)
Participants: The final study cohort consisted of 2294 patients (57.2% males, median age 57 years) with suspected ACS.
Interventions: Using the new dual markers strategy, 1477 patients were eligible for direct discharge, which was realised in 974 (42.5%) of patients.
Main outcome measures: The primary endpoint was all-cause mortality at 30 days.
Results: Compared with conventional workup after dual marker measurement, the median length of ED stay was 60 min shorter (228 min, 95% CI: 219 to 239 min vs 288 min, 95% CI: 279 to 300 min) in the primary dual marker strategy (DMS) discharge group. All-cause mortality was 0.1% (95% CI: 0% to 0.6%) in the primary DMS discharge group versus 1.1% (95% CI: 0.6% to 1.8%) in the conventional workup group after dual marker measurement. Conventional workup instead of discharge despite negative DMS biomarkers was observed in 503 patients (21.9%) and associated with higher prevalence of ACS (17.1% vs 0.9%, p<0.001), cardiac diagnoses (55.2% vs 23.5%, p<0.001) and risk factors (p<0.01), but with a similar all-cause mortality of 0.2% (95% CI: 0% to 1.1%) versus primary DMS discharge (p=0.64).
Conclusions: Copeptin on top of cardiac troponin supports safe discharge in patients with chest pain or other symptoms suggestive of ACS under routine conditions with the use of a broad spectrum of local standard POC, conventional and high-sensitivity troponin assays.
Trial registration number NCT02490969.
Anaplastic large cell lymphoma (ALCL) and classical Hodgkin lymphoma (cHL) are lymphomas that contain CD30-expressing tumor cells and have numerous pathological similarities. Whereas ALCL is usually diagnosed at an advanced stage, cHL more frequently presents with localized disease. The aim of the present study was to elucidate the mechanisms underlying the different clinical presentation of ALCL and cHL. Chemokine and chemokine receptor expression were similar in primary ALCL and cHL cases apart from the known overexpression of the chemokines CCL17 and CCL22 in the Hodgkin and Reed-Sternberg (HRS) cells of cHL. Consistent with the overexpression of these chemokines, primary cHL cases encountered a significantly denser T cell microenvironment than ALCL. Additionally to differences in the interaction with their microenvironment, cHL cell lines presented a lower and less efficient intrinsic cell motility than ALCL cell lines, as assessed by time-lapse microscopy in a collagen gel and transwell migration assays. We thus propose that the combination of impaired basal cell motility and differences in the interaction with the microenvironment hamper the dissemination of HRS cells in cHL when compared with the tumor cells of ALCL.
Health-related preferences of older patients with multimorbidity: the protocol for an evidence map
(2019)
Introduction: Interaction of conditions and treatments, complicated care needs and substantial treatment burden make patient–physician encounters involving multimorbid older patients highly complex. To optimally integrate patients’ preferences, define and prioritise realistic treatment goals and individualise care, a patient-centred approach is recommended. However, the preferences of older patients, who are especially vulnerable and frequently multimorbid, have not been systematically investigated with regard to their health status. The purpose of this evidence map is to explore current research addressing health-related preferences of older patients with multimorbidity, and to identify the knowledge clusters and research gaps.
Methods and analysis: To identify relevant research, we will conduct searches in the electronic databases MEDLINE, EMBASE, PsycINFO, PSYNDEX, CINAHL, Social Science Citation Index, Social Science Citation Index Expanded and the Cochrane library from their inception. We will check reference lists of relevant articles and carry out cited reference research (forward citation tracking). Two independent reviewers will screen titles and abstracts, check full texts for eligibility and extract the data. Any disagreement will be resolved and consensus reached with the help of a third reviewer. We will include both qualitative and quantitative studies, and address preferences from the patients’ perspectives in a multimorbid population of 60 years or older. There will be no restrictions on the publication language. Data extraction tables will present study and patient characteristics, aim of study, methods used to identify preferences and outcomes (ie, type of preferences). We will summarise the data using tables and figures (ie, bubble plot) to present the research landscape and to describe clusters and gaps.
Ethics and dissemination: Due to the nature of the proposed evidence map, ethics approval will not be required. Results from our research will be disseminated by means of specifically prepared materials for patients, at relevant (inter)national conferences and via publication in peer-reviewed journals.
Background: The nonmotor symptom spectrum of Parkinson’s disease (PD) includes progressive cognitive decline mainly in late stages of the disease. The aim of this study was to map the patterns of altered structural connectivity of patients with PD with different cognitive profiles ranging from cognitively unimpaired to PD-associated dementia.
Methods: Diffusion tensor imaging and neuropsychological data from the observational multicentre LANDSCAPE study were analyzed. A total of 134 patients with PD with normal cognitive function (56 PD-N), mild cognitive impairment (67 PD-MCI), and dementia (11 PD-D) as well as 72 healthy controls were subjected to whole-brain-based fractional anisotropy mapping and covariance analysis with cognitive performance measures.
Results: Structural data indicated subtle changes in the corpus callosum and thalamic radiation in PD-N, whereas severe white matter impairment was observed in both PD-MCI and PD-D patients including anterior and inferior fronto-occipital, uncinate, insular cortices, superior longitudinal fasciculi, corona radiata, and the body of the corpus callosum. These regional alterations were demonstrated for PD-MCI and were more pronounced in PD-D. The pattern of involved regions was significantly correlated with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) total score.
Conclusions: The findings in PD-N suggest impaired cross-hemispherical white matter connectivity that can apparently be compensated for. More pronounced involvement of the corpus callosum as demonstrated for PD-MCI together with affection of fronto-parieto-temporal structural connectivity seems to lead to gradual disruption of cognition-related cortico-cortical networks and to be associated with the onset of overt cognitive deficits. The increase of regional white matter damage appears to be associated with the development of PD-associated dementia.
Preclinical studies point to a pivotal role of the orexin 1 (OX1) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a multilevel approach was applied to test the non-synonymous HCRTR1 C/T Ile408Val gene variant (rs2271933) for association with PD/AG in two independent case-control samples (total n = 613 cases, 1839 healthy subjects), as an outcome predictor of a six-weeks exposure-based cognitive behavioral therapy (CBT) in PD/AG patients (n = 189), as well as with respect to agoraphobic cognitions (ACQ) (n = 483 patients, n = 2382 healthy subjects), fMRI alerting network activation in healthy subjects (n = 94), and a behavioral avoidance task in PD/AG pre- and post-CBT (n = 271). The HCRTR1 rs2271933 T allele was associated with PD/AG in both samples independently, and in their meta-analysis (p = 4.2 × 10−7), particularly in the female subsample (p = 9.8 × 10−9). T allele carriers displayed a significantly poorer CBT outcome (e.g., Hamilton anxiety rating scale: p = 7.5 × 10−4). The T allele count was linked to higher ACQ sores in PD/AG and healthy subjects, decreased inferior frontal gyrus and increased locus coeruleus activation in the alerting network. Finally, the T allele count was associated with increased pre-CBT exposure avoidance and autonomic arousal as well as decreased post-CBT improvement. In sum, the present results provide converging evidence for an involvement of HCRTR1 gene variation in the etiology of PD/AG and PD/AG-related traits as well as treatment response to CBT, supporting future therapeutic approaches targeting the orexin-related arousal system.
Highlights
• The goal was to assess the intra- and inter-scanner reproducibility of qMRI data.
• Mean scan-rescan variations were not exceeding 2.14%.
• Mean inter-scanner model deviations were not exceeding 5.21%.
• Provided that identical acquisition sequences are used, discrepancies between qMRI data acquired with different scanner models are low.
Abstract
Background: Quantitative MRI (qMRI) techniques allow assessing cerebral tissue properties. However, previous studies on the accuracy of quantitative T1 and T2 mapping reported a scanner model bias of up to 10% for T1 and up to 23% for T2. Such differences would render multi-centre qMRI studies difficult and raise fundamental questions about the general precision of qMRI. A problem in previous studies was that different methods were used for qMRI parameter mapping or for measuring the transmitted radio frequency field B1 which is critical for qMRI techniques requiring corrections for B1 non-uniformities.
Aims: The goal was to assess the intra- and inter-scanner reproducibility of qMRI data at 3 T, using two different scanner models from the same vendor with exactly the same multiparametric acquisition protocol.
Methods: Proton density (PD), T1, T2* and T2 mapping was performed on healthy subjects and on a phantom, performing each measurement twice for each of two scanner models. Although the scanners had different hardware and software versions, identical imaging sequences were used for PD, T1 and T2* mapping, adapting the codes of an existing protocol on the older system line by line to match the software version of the newer scanner. For T2-mapping, the respective manufacturer’s sequence was used which depended on the software version. However, system-dependent corrections were carried out in this case. Reproducibility was assessed by average values in regions of interest.
Results: Mean scan-rescan variations were not exceeding 2.14%, with average values of 1.23% and 1.56% for the new and old system, respectively. Inter-scanner model deviations were not exceeding 5.21% with average values of about 2.2–3.8% for PD, 2.5–3.0% for T2*, 1.6–3.1% for T1 and 3.3–5.2% for T2.
Conclusions: Provided that identical acquisition sequences are used, discrepancies between qMRI data acquired with different scanner models are low. The level of systematic differences reported in this work may help to interpret multi-centre data.
Multimodal quantitative mri reveals no evidence for tissue pathology in idiopathic cervical dystonia
(2019)
Background: While in symptomatic forms of dystonia cerebral pathology is by definition present, it is unclear so far whether disease is associated with microstructural cerebral changes in idiopathic dystonia. Previous quantitative MRI (qMRI) studies assessing cerebral tissue composition in idiopathic dystonia revealed conflicting results.
Objective: Using multimodal qMRI, the presented study aimed to investigate alterations in different cerebral microstructural compartments associated with idiopathic cervical dystonia in vivo.
Methods: Mapping of T1, T2, T∗2, and proton density (PD) was performed in 17 patients with idiopathic cervical dystonia and 29 matched healthy control subjects. Statistical comparisons of the parametric maps between groups were conducted for various regions of interest (ROI), including major basal ganglia nuclei, the thalamus, white matter, and the cerebellum, and voxel-wise for the whole brain.
Results: Neither whole brain voxel-wise statistics nor ROI-based analyses revealed significant group differences for any qMRI parameter under investigation.
Conclusions: The negative findings of this qMRI study argue against the presence of overt microstructural tissue change in patients with idiopathic cervical dystonia. The results seem to support a common view that idiopathic cervical dystonia might primarily resemble a functional network disease.
Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection.
Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L).
Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05).
Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.
Preclinical studies have demonstrated that the endocannabinoid system (ECS) plays an important role in the protection against intestinal inflammation and colorectal cancer (CRC); however, human data are scarce. We determined members of the ECS and related components of the ‘endocannabinoidome’ in patients with inflammatory bowel disease (IBD) and CRC, and compared them to control subjects. Anandamide (AEA) and oleoylethanolamide (OEA) were increased in plasma of ulcerative colitis (UC) and Crohn’s disease (CD) patients while 2-arachidonoylglycerol (2-AG) was elevated in patients with CD, but not UC. 2-AG, but not AEA, PEA and OEA, was elevated in CRC patients. Lysophosphatidylinositol (LPI) 18:0 showed higher levels in patients with IBD than in control subjects whereas LPI 20:4 was elevated in both CRC and IBD. Gene expression in intestinal mucosal biopsies revealed different profiles in CD and UC. CD, but not UC patients, showed increased gene expression for the 2-AG synthesizing enzyme diacylglycerol lipase alpha. Transcripts of CNR1 and GPR119 were predominantly decreased in CD. Our data show altered plasma levels of endocannabinoids and endocannabinoid-like lipids in IBD and CRC and distinct transcript profiles in UC and CD. We also report alterations for less known components in intestinal inflammation, such as GPR119, OEA and LPI.
The precise understanding of the dopaminergic (DA) system and its pharmacological modifications is crucial for diagnosis and treatment of neuropsychiatric disorders, as well as for understanding basic processes, such as motivation and reward. We probed the functional connectivity (FC) of subcortical nuclei related to the DA system according to seed regions defined according to an atlas of subcortical nuclei. We conducted a large pharmaco-fMRI study using a double-blind, placebo-controlled design, where we examined the effect of l -DOPA, a dopamine precursor, and amisulpride, a D2/D3-receptor antagonist on resting-state FC in 45 healthy young adults using a cross-over design. We examined the FC of subcortical nuclei with connection to the reward system and their reaction to opposing pharmacological probing. Amisulpride increased FC from the putamen to the precuneus and from ventral striatum to precentral gyrus. l -DOPA increased FC from the ventral tegmental area (VTA) to the insula/operculum and between ventral striatum and ventrolateral prefrontal cortex and it disrupted ventral striatal and dorsal caudate FC with the medial prefrontal cortex. In an exploratory analysis, we demonstrated that higher self-rated impulsivity goes together with a significant increase in VTA-mid-cingulate gyrus FC during l -DOPA-challenge. Therefore, our DA challenge modulated distinct large-scale subcortical connectivity networks. A dopamine-boost can increase midbrain DA nuclei connectivity to the cortex. The involvement of the VTA-cingulum connectivity in dependence of impulsivity has implications for diagnosis and therapy in disorders like ADHD.
Aim: To assess outcomes in patients with advanced adenocarcinoma non-small-cell lung cancer who received nintedanib plus docetaxel after progression on prior chemotherapy followed by immune checkpoint inhibitor (ICI) therapy. Patients & methods: VARGADO is a prospective, noninterventional study. We describe initial data from a cohort of 22 patients who received nintedanib plus docetaxel after chemotherapy and ICI therapy. Results: Median progression-free survival with nintedanib plus docetaxel was 5.5 months (95% CI: 1.9–8.7 months). The objective response rate was 7/12 (58%) and the disease control rate was 10/12 (83%). Data for overall survival rate 12 months after the start of treatment (primary end point) are not yet mature and are not reported. Of 22 patients, 73% experienced drug-related adverse events; adverse events led to treatment discontinuation in 32% of patients. Conclusion: These data highlight the potential clinical benefit of nintedanib plus docetaxel in patients who failed prior ICI therapy.
Trial registration number: NCT02392455
Systematic reviews represent the core and backbone of evidence-based medicine (EBM) strategies in all fields of medicine. In order to depict a first global sketch of the international efforts in the Cochrane database systematic reviews (CDSR), we analyzed the systematic reviews of the Cochrane database. Our global maps of systematic reviewing offer intriguing structural insights into the world of EBM strategies. They demonstrate that for the CDSR, the UK and Commonwealth countries take the lead position. Since patients, care providers and health systems all over the world benefit from systematic reviewing, institutions in other countries should increase their commitment.
Objective: Excessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune responses in Parkinson disease patients are dysregulated, leading to an increased inflammatory reaction to unspecific triggers. Although α‐synuclein pathology is the hallmark of Parkinson disease, it has not been investigated whether pathologic α‐synuclein is a specific trigger for excessive inflammatory responses in Parkinson disease.
Methods: We investigated the immune response of primary human monocytes and a microglial cell line to pathologic forms of α‐synuclein by assessing cytokine release upon exposure.
Results: We show that pathologic α‐synuclein (mutations, aggregation) results in a robust inflammatory activation of human monocytes and microglial BV2 cells. The activation is conformation‐ dependent, with increasing fibrillation and early onset mutations having the strongest effect on immune activation. We also found that activation of immune cells by extracellular α‐synuclein is potentiated by extracellular vesicles, possibly by facilitating the uptake of α‐synuclein. Blood extracellular vesicles from Parkinson disease patients induce a stronger activation of monocytes than blood extracellular vesicles from healthy controls. Most importantly, monocytes from Parkinson disease patients are dysregulated and hyperactive in response to stimulation with pathologic α‐synuclein. Furthermore, we demonstrate that α‐synuclein pathology in the CNS is sufficient to induce the monocyte dysregulation in the periphery of a mouse model.
Interpretation: Taken together, our data suggest that α‐synuclein pathology and dysregulation of monocytes in Parkinson disease can act together to induce excessive inflammatory responses to α‐synuclein. ANN NEUROL 2019;86:593–606
Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (n = 11) may be characterized by genomic patterns indicative of defective homologous recombination (HR) DNA repair and alterations affecting HR-related genes, including, for example, deletions and pathogenic germline variants of BRCA2, NBN, and CHEK2. A mutational signature associated with HR deficiency was significantly enriched in 72.7% of samples and co-occurred with genomic instability. The poly(ADP-ribose) polymerase (PARP) inhibitor olaparib, which is preferentially toxic to HR-incompetent cells, led to prolonged clinical benefit in a patient with refractory chordoma, and whole-genome analysis at progression revealed a PARP1 p.T910A mutation predicted to disrupt the autoinhibitory PARP1 helical domain. These findings uncover a therapeutic opportunity in chordoma that warrants further exploration, and provide insight into the mechanisms underlying PARP inhibitor resistance.
Objective: The DIRAS2 gene is associated with ADHD, but its function is largely unknown. Thus, we aimed to explore the genes and molecular pathways affected by DIRAS2. Method: Using short hairpin RNAs, we downregulated Diras2 in murine hippocampal primary cells. Gene expression was analyzed by microarray and affected pathways were identified. We used quantitative real-time polymerase chain reaction (qPCR) to confirm expression changes and analyzed enrichment of differentially expressed genes in an ADHD GWAS (genome-wide association studies) sample. Results: Diras2 knockdown altered expression of 1,612 genes, which were enriched for biological processes involved in neurodevelopment. Expression changes were confirmed for 33 out of 88 selected genes. These 33 genes showed significant enrichment in ADHD patients in a gene-set-based analysis. Conclusion: Our findings show that Diras2 affects numerous genes and thus molecular pathways that are relevant for neurodevelopmental processes. These findings may further support the hypothesis that DIRAS2 is linked to etiological processes underlying ADHD. (J. of Att. Dis. 2021; 25(4) 572-583).
Based on accumulating evidence of a role of lipid signaling in many physiological and pathophysiological processes including psychiatric diseases, the present data driven analysis was designed to gather information needed to develop a prospective biomarker, using a targeted lipidomics approach covering different lipid mediators. Using unsupervised methods of data structure detection, implemented as hierarchal clustering, emergent self-organizing maps of neuronal networks, and principal component analysis, a cluster structure was found in the input data space comprising plasma concentrations of d = 35 different lipid-markers of various classes acquired in n = 94 subjects with the clinical diagnoses depression, bipolar disorder, ADHD, dementia, or in healthy controls. The structure separated patients with dementia from the other clinical groups, indicating that dementia is associated with a distinct lipid mediator plasma concentrations pattern possibly providing a basis for a future biomarker. This hypothesis was subsequently assessed using supervised machine-learning methods, implemented as random forests or principal component analysis followed by computed ABC analysis used for feature selection, and as random forests, k-nearest neighbors, support vector machines, multilayer perceptron, and naïve Bayesian classifiers to estimate whether the selected lipid mediators provide sufficient information that the diagnosis of dementia can be established at a higher accuracy than by guessing. This succeeded using a set of d = 7 markers comprising GluCerC16:0, Cer24:0, Cer20:0, Cer16:0, Cer24:1, C16 sphinganine, and LacCerC16:0, at an accuracy of 77%. By contrast, using random lipid markers reduced the diagnostic accuracy to values of 65% or less, whereas training the algorithms with randomly permuted data was followed by complete failure to diagnose dementia, emphasizing that the selected lipid mediators were display a particular pattern in this disease possibly qualifying as biomarkers.
Cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) are frequently used as add-on medication for the treatment of asthma. Recently, these compounds have shown protective effects in cardiovascular diseases. This prompted us to investigate their influence on soluble epoxide hydrolase (sEH) and peroxisome proliferator activated receptor (PPAR) activities, two targets known to play an important role in CVD and the metabolic syndrome. Montelukast, pranlukast and zafirlukast inhibited human sEH with IC50 values of 1.9, 14.1, and 0.8 μM, respectively. In contrast, only montelukast and zafirlukast activated PPARγ in the reporter gene assay with EC50 values of 1.17 μM (21.9% max. activation) and 2.49 μM (148% max. activation), respectively. PPARα and δ were not affected by any of the compounds. The activation of PPARγ was further investigated in 3T3-L1 adipocytes. Analysis of lipid accumulation, mRNA and protein expression of target genes as well as PPARγ phosphorylation revealed that montelukast was not able to induce adipocyte differentiation. In contrast, zafirlukast triggered moderate lipid accumulation compared to rosiglitazone and upregulated PPARγ target genes. In addition, we found that montelukast and zafirlukast display antagonistic activities concerning recruitment of the PPARγ cofactor CBP upon ligand binding suggesting that both compounds act as PPARγ modulators. In addition, zafirlukast impaired the TNFα triggered phosphorylation of PPARγ2 on serine 273. Thus, zafirlukast is a novel dual sEH/PPARγ modulator representing an excellent starting point for the further development of this compound class.