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This monograph describes the overall language situation in Luxembourg, a highly multilingual country in Western Europe, from a language policy and planning perspective. The first part discusses the social and historical contexts, including major societal changes and uncertainties about the future, which are bound up with Europeanisation and the accelerated processes of globalisation. It also deconstructs the notions of Luxembourgish as a 'minority language' and French as the 'language of prestige', and describes a two-pronged language ideology that allows for either monolingual identification with Luxembourgish or trilingual identification with the languages recognised by the language law of 1984 (Luxembourgish / German / French). The second part discusses the trilingual school-system, a system in which large numbers of romanophone students are forced to go through a German-language literacy programme. The third part provides an overview of language spread in the areas of the media and literary writing. The fourth part examines language purism and tensions concerning the standardisation of Luxembourgish, as well as the debates about language requirements for citizenship. The discussion shows how language policy scholarship needs to be approached from a multidimensional perspective, that is, by taking into account dynamics on the global, regional and local levels in addition to those at the state level.
Advantageous fragmentation? : reimagining metropolitan governance and spatial planning in Rhine-Main
(2006)
This paper traces the latest round of debates about appropriate scales and scopes of government and governance in Rhine-Main - an economically highly integrated but politically, territorially and emotionally divided region. We identify a downscaling of political power from the regional to the municipal level, and an upscaling of informal networking and image building to an extended regional scale. These countertrends are signs of a more complex geographical rearrangement in municipal and institutional relations. The inherent contradictions in the rescaling and reimagining of Rhine-Main are evident in the Strategic Vision for Frankfurt/Rhein-Main 2020. Its new conceptualization of Rhine-Main postulates complementary polycentricity as a competitive asset but remains firmly grounded in an institutional territorial logic that contravenes its own economically-driven agenda.
Arthropods use fluid medium motion-sensing filiform hairs on their exoskeleton to detect aerodynamic or hydrodynamic stimuli in their surroundings that affect their behaviour. The hairs, often of different lengths and organized in groups or arrays, respond to particular fluid motion amplitudes and frequencies produced by prey, predators, or conspecifics, even in the presence of background noise peculiar to the environment. While long known to biologists and experimentally investigated by them, it is only relatively recently that comprehensive physical-mathematical models have emerged offering an alternative methodology for investigating the biomechanics of filiform hair motion. These models have been developed and applied to quantitatively predict the performance characteristics of filiform hairs in air and water as a function of the relevant parameters that affect their physical behaviour. They even allow the exploration of possible biological evolutionary paths for filiform hair changes resulting from physical selection pressures. In this chapter we review the state of knowledge of filiform hair biomechanics and discuss two physical-mathematical models to predict hair dynamical behaviour. One modelling approach is analytically exact, serving for quantitative purposes, while the other, derived from it, is approximate, serving for qualitative guidance concerning the parameter dependencies of hair motion. Using these models we look in turn at the influence of these parameters and the fluid media physical properties on hair motion, including the possibility of medium-facilitated viscous coupling between hairs. The models point to areas where data is currently lacking and future research could be focused. In addition, new results are presented pertaining to transient tlows. We qualitatively explore the possibility of an overlapping water-air niches adaptation potential that may explain how, over many generations, the filiform hairs of an arthropod living in water could have evolved to function in air. Because flow-sensing hairs have served to inspire corresponding artificial medium motion microsensors, we discuss recent advances in this area. Significant challenges remain to be overcome, especially with respect to the materials and fabrication techniques used. In spite of the impressive technological advances made, nature still remains unrivalled.
Let’s not forget that 1492, one of the first landmarks of Modernity, was both the year of the conquest of the Americas and of the fall or of the Reconquista of Granada, both of inner and outer ethnic cleansing of the nation state; that the national state was a colonial state and is now a securitarian state, that colonialism was the very form of Western Modernity, that the French Revolution itself was colonial, that the leader of the first Black revolutionary independence movement, Toussaint Louverture (Haiti), died in a French prison though inspired by the French Revolution. - No-one has access to reason as whole: there is no such thing as the whole of Reason, or Reason as a whole, or the Totality of reason. Reason is patched up of disconnected bits and pieces that reside at different addresses.
The special issue of The Linguistic Review on "The Role of Linguistics in Cognitive Science" presents a variety of viewpoints that complement or contrast with the perspective offered in Foundations of Language (Jackendoff 2002a). The present article is a response to the special issue. It discusses what it would mean to integrate linguistics into cognitive science, then shows how the parallel architecture proposed in Foundations seeks to accomplish this goal by altering certain fundamental assumptions of generative grammar. It defends this approach against criticisms both from mainstream generative grammar and from a variety of broader attacks on the generative enterprise, and it reflects on the nature of Universal Grammar. It then shows how the parallel architecture applies directly to processing and defends this construal against various critiques. Finally, it contrasts views in the special issue with that of Foundations with respect to what is unique about language among cognitive capacities, and it conjectures about the course of the evolution of the language faculty.
Background: Only few authors have analyzed the impact of workplace conflicts and the resulting stress on the risk of developing cardiovascular disorders. The goal of this study was to analyze the association between workplace conflicts and cardiovascular disorders in patients treated by German general practitioners.
Methods: Patients with an initial documentation of a workplace conflict experience between 2005 and 2014 were identified in 699 general practitioner practices (index date). We included only those who were between the ages of 18 and 65 years, had a follow-up time of at least 180 days after the index date, and had not been diagnosed with angina pectoris, myocardial infarction, coronary heart diseases, or stroke prior to the documentation of the workplace mobbing. In total, the study population consisted of 7,374 patients who experienced conflicts and 7,374 controls for analysis. The main outcome measure was the incidence of angina pectoris, myocardial infarction, and stroke correlated with workplace conflict experiences.
Results: After a maximum of five years of follow-up, 2.9% of individuals who experienced workplace conflict were affected by cardiovascular diseases, while only 1.4% were affected in the control group (p-value <0.001). Workplace conflict was associated with a 1.63-fold increase in the risk of developing cardiovascular diseases. Finally, the impact of workplace conflict was higher for myocardial infarction (OR=2.03) than for angina pectoris (OR=1.79) and stroke (OR=1.56).
Conclusions: Overall, we found a significant association between workplace conflicts and cardiovascular disorders.
In this paper we propose a compositional semantics for lexicalized tree-adjoining grammar (LTAG). Tree-local multicomponent derivations allow separation of the semantic contribution of a lexical item into one component contributing to the predicate argument structure and a second component contributing to scope semantics. Based on this idea a syntax-semantics interface is presented where the compositional semantics depends only on the derivation structure. It is shown that the derivation structure (and indirectly the locality of derivations) allows an appropriate amount of underspecification. This is illustrated by investigating underspecified representations for quantifier scope ambiguities and related phenomena such as adjunct scope and island constraints.
Purpose: DINO and DACOTA were prospective, noninterventional studies assessing the health status and quality of life of patients with COPD newly treated with roflumilast 500 µg once-daily add-on therapy.
Patients and methods: Patients were evaluated over 6 months. Clinical COPD questionnaire (CCQ) and COPD assessment test (CAT) scores were recorded at baseline and after 3 and 6 months. In DACOTA, post-bronchodilator FEV1 was recorded at each time point.
Results: Of 5,462 and 3,645 patients recruited into DINO and DACOTA, respectively, 3,274 patients in DINO and 916 patients in DACOTA completed the 6-month visit. Almost all patients had severe or very severe airway obstruction; mean baseline CCQ total score was 3.9 in DINO and 3.7 in DACOTA. Overall, 33.8% of patients in DACOTA and 30.6% in DINO discontinued treatment prematurely. Significant and clinically relevant improvements in CCQ total scores were observed in both studies (mean change from baseline of 1.36 in DINO and 0.91 in DACOTA at Month 6 [all P<0.001]). Changes in CAT total score from baseline to Month 6 indicated that the average clinical impact of COPD was reduced from a severe (score: 21–30) to a moderate (score: 11–20) impairment. In DACOTA, mean change in post-bronchodilator FEV1 was 202 mL (P<0.001). Diarrhea, nausea, and weight decrease were the most frequently reported adverse drug reactions.
Conclusion: In real-life clinical practice, roflumilast treatment as an add-on therapy is associated with clinically relevant improvements in health status and quality of life.
The re-emergence of tuberculosis in its present-day manifestations - single, multiple and extensive drug-resistant forms and as HIV-TB coinfections - has resulted in renewed research on fundamental questions such as the nature of the organism itself, Mycobacterium tuberculosis, the molecular basis of its pathogenesis, definition of the immunological response in animal models and humans, and development of new intervention strategies such as vaccines and drugs. Foremost among these developments has been the precise chemical definition of the complex and distinctive cell wall of M. tuberculosis, elucidation of the relevant pathways and underlying genetics responsible for the synthesis of the hallmark moieties of the tubercle bacillus such as the mycolic acid-arabinogalactan-peptidoglycan complex, the phthiocerol- and trehalose-containing effector lipids, the phosphatidylinositol-containing mannosides, lipomannosides and lipoarabinomannosides, major immunomodulators, and others. In this review, the laboratory personnel who have been the focal point of some to these developments review recent progress towards a comprehensive understanding of the basic physiology and functions of the cell wall of M. tuberculosis.
A glimpse of the tropics : spiders (Araneae) in the greenhouses of the Botanic Garden Berlin-Dahlem
(2008)
In a survey of the spider fauna in greenhouses of the Botanic Garden Berlin-Dahlem, 30 spider species were recorded. Two species are new to Europe: Theotima minutissima (Petrunkevitch, 1929) and Heteroonops spinimanus (Simon, 1891). T. minutissima is the first member of the family Ochyroceratidae reported from Europe. Oecobius navus Blackwall, 1859 is new to Central Europe. Triaeris stenaspis Simon, 1891, is recorded from Germany for the first time. Zodarion italicum (Canestrini, 1868) is new to eastern Germany. Despite the discovery of some species previously unknown to Germany, the spider fauna in the Botanic Garden consisted mainly of wellknown synanthropic species and common inhabitants of greenhouses. Several alien spiders recently found in greenhouses, garden centers and houses were not recorded in the Botanic Garden. The species composition of the exotic spider fauna in greenhouses seems to depend chiefly on the specific modes of acquisition of plants and plant substrate.
The following changes in nomenclature of some species of Amblyeems Thunberg, 1815, are proposed: A) Elevated to new taxonomic status- A. insuturatus (pic, 1902) from (Spennophagus subflavidus var.insuturatus); A. luteolineatus (pic, 1929) from (Spennophagus luteonotatus var .luteolineatus);A. paulonotatus (pic, 1906) from (Spennophagus luteonotatus var.paulonotatus). B) New synonymy-A. dispar(Sharp, 1885)(=Spermophagus longissimus Pic, 1902; =S. earyoborifonnis Pic, 1910; =S. guyanensis Pic, 1917; S.pieeosuturalis Pic, 1927; =S. earaeasensis Pic, 1954); A. gounellei (pic. 1902)(=S. eurtus Pic, 1911; =S. basipennis Pic, 1936); A. insuturatus (pic, 1902)(=A. woleotti Kingsolver, 1970;A.jatayensis (Pic, 1902)(=S.jatayensis var. bieolorieeps Pic, 1955; =S.jatayensis var. hahnelli Pic, 1955; A. IIwltimaculatus (pic, 1902)( =S. minasensis Pic, 1918); A. perfectus (Sharp, 1885)(=S. maeulatopygus Pic, 1927); A. reticulatus (Jekel, 1855)(=S. rufotestaeeus Pic, 1912);A.luteolineatus (pic, 1929)(=S. multisignatus Pic, 1954). C). Lectotype/s and paralectotype/s are designated for: S. luteonotatus Pic, 1902; S. multimaeulatus Pic, 1902; S. maeulatopygus Pic, 1927; S. subflavidus Pic, 1902; S. trisignatus Sharp, 1885; S.jatayensis Pic, 1902; S. longissimus Pic, 1902; S. earyoborifonnis Pic, 1910; S. dispar Sharp, 1885; S. subflavidusvar. insuturatus Pic, 1902. For all species listed in this paper, we provide a bibliography, label data on type material, sex of types and their repository.
The sting apparatus and pygidium are described for eight of 20 Lordomyrma species and one of five Mayriella species. The apparatus of L. epinotaiis is distinctly different from that of other Lordomyrma species. Comparisons with other genera suggest affinities of species of Lordomyrma to species of Cyphoidris and Lachnomyrmex, while Mayriella abstinens Forel shares unusual features with those of Proatta butteli.
This review lists Agama smithii Boulenger 1896 as a synonym of Agama agama (Linnaeus 1758), Agama trachypleura Peters 1982 as a synonym of Acanthocercus phillipsii (Boulenger 1895) and describes for the first time Acanthocercus guentherpetersi n. sp. Without more convincing evidence, Chamaeleon ruspolii Boettger 1893 cannot be accepted as specifically distinct from Chamaeleo dilepis Leach 1819, nor Chamaeleo calcaricarens Böhme 1985 from C. africanus Laurenti 1768. Consequently, 101 species of lizard are currently recognised in Ethiopia, of which some 40% appear to be denizens of the Somali-arid zone. This significant proportion is attributable in part to the importance of the Horn of Africa as a centre for reptilian diversification and endemicity, in part to the fact that this lowland fauna was rather extensively sampled during the 1930s, but also to the conspicuous neglect of lizards in other regions of the country. Mountain and forested habitats are widespread in Ethiopia, so it seems extraordinary to record only five saurian species which are believed to be endemic in such environments. The inference that there are many more still to be discovered has important implications for conservation, because montane forest is known to be among the most threatened of Ethiopian biomes and there is clearly an urgent need for its herpetofauna to be more thoroughly researched and documented.
A review of biological control efforts against Diptera of medical and veterinary importance includes pertinent literature of major dipterous taxonomic groups where some success has been achieved or where work is currently being conducted on species breeding in aquatic (e.g., mosquitoes, blackflies, tabanids) and terrestrial habitats (muscids, tsetse, etc.). Most effort has been directed against aquatic Diptera because of the human and animal disease agents they transmit. Research has established that the natural enemy component frequently is responsible for significant population reduction and indispensable to integrated control which seeks to maintain populations below annoyance or disease transmission levels. The manipulation of natural enemies through introduction and/or augmentation has in some cases provided satisfactory control, and sustained releases of natural enemies over several years may overcome the relative high cost of massive release rates. Ultimately, to guarantee the existence and maximum expression of resident natural enemies has become almost universally accepted, and challenging, to sound control practices. Indeed, chemical industry recognizing this, has sought to manufacture products such as Bacillus toxins, juvenile hormones, and baits that are minimally disruptive to existing natural controls. Although such easily applied products have been widely adopted, their cost continues to become prohibitive with developing resistance, as was observed earlier with many organophosphate and chlorinated hydrocarbon insecticides. Further advancements in the control ofthese Diptera should continue to embrace a sound appreciation for the natural control component and nurture ways to allow its maximum expression. Keyword Index: Biological Control, Diptera, Medical, Veterinary.
The purpose of this study of early social-cognitive development was to assess the very young child's behaviorally expressed knowledge of people's visual-attentional acts and abilities. Boys and girls (N = 60) 1, 1 1/2, 2, 2 1/2, and 3 years of age were tested in their homes with their mothers' help. Three sorts of tasks were used: 1. Percept production. The child's task was to produce a visual percept in the other. Examples include pointing to objects ("productive pointing") and a wide variety of object-showing problems. 2. Percept deprivation. The opposite, exemplified by a variety of object-hiding problems. 3. Percept diagnosis. The child's task was to determine what the other was already visually attending to, either by looking where his or her finger was pointed ("receptive pointing") or where his eyes were directed. It was found that the majority of l-year-olds produced and comprehended pointing, and would sometimes hold out a toy to show it, but did little else. The 3-year-olds were at ceiling on virtually all tasks. At 1 1/2 years, children usually showed a picture by holding it flat so that both they and the other could see it. From 2 on, they usually turned it toward the other in the adult fashion. Very few children of any age showed egocentrically - i.e., orienting the picture so only they could see it. By age 2, the children solved what were presumably novel showing problems for them: e.g., successfully showing to another a picture pasted on the inside bottom of a hollow cube. Hiding ability emerged later than showing ability but seemed well established by age 3. The role of the other's eyes in seeing appeared to be quite well understood at least by age 2-2 1/2. As examples, children of this age took the other's hands away from her or his eyes before trying to show her something, and could usually tell where she was looking from her eye orientation alone. These age trends presumably reflect important developments in the area of social interaction and communication, as well as with respect to cognition about percepts.
The focus of this paper is the perspectivization of thematic roles generally and the recipient role specifically. Whereas perspective is defined here as the representation of something for someone from a given position (Sandig 1996: 37), perspectivization refers to the verbalization of a situation in the speech generation process (Storrer 1996: 233). In a prototypical act of giving, for example, the focus of perception (the attention of the external observer) may be on the person who gives (agent), the transferred object (patient) or the person who receives the transferred object (recipient). The languages of the world provide differing linguistic means to perspectivize such an act of giving, or better: to perspectivize the participants of such an action. In this article, the linguistic means of three selected continental West Germanic languages –German, Dutch and Luxembourgish– will be taken into consideration, with an emphasis on the perspectivization of the recipient role.
One of the byproducts of World War II of which society is hardly aware is the new stage of development which the social sciences have reached. This development indeed may prove to be as revolutionary at the atom bomb. Applying cultural anthropology to modern rather than "primitive" cultures, experimentation with groups inside and outside the laboratory, the measurement of sociopsychological aspects of large social bodies, the combination of economic, cultural, and psychological fact-finding, all of these developments started before the war. But, by providing unprecedented facilities and by demanding realistic and workable solutions to scientific problems, the war has accelerated greatly the change of social sciences to a new development level. The scientific aspects of this development center around three objectives: (1) Integrating social sciences. (2) Moving from the description of social bodies to dynamic problems of changing group life. (3) Developing new instruments and techniques of· social research. Theoretical progress has hardly kept pace with the development of techniques. It is, however, as true for the social as for the physical and biological sciences that without adequate conceptual development, science cannot proceed beyond a certain stage. It is an important step forward that the hostility to theorizing which dominated a number of social sciences ten years ago has all but vanished. It has been replaced by a relatively wide-spread recognition of the necessity for developing better concepts and higher levels of theory. The theoretical development will have to proceed rather rapidly if social science is to reach that level of practical usefulness which society needs for winning the race against the destructive capacities set free by man's use of the llatural sciences. I should like to survey certain concepts and theories which have emerged mainly from experimental research. They concern: (a) Quasi-stationary social equilibria and social changes. (b) Locomotion through social channels. (c) Social feedback processes and social management. The last two of these will be dealt with in a later article. A cursory introductory discussion of certain aspects of the present state of affairs in social science is included here for those readers who are interested in the general background of these concepts and in the problems from which they have sprung.
Six species of the genus Polyplectropns are recorded from the People's Republic of China. All the species are new to science. A key to the males is given. The larva of Polyplectropns nanjingensis sp. nov. is illustrated. The phylogenetic relationships among these species and with Polyplectropns species of the New World are discussed.
The phylogenetic relationships of the species of Padunielia are analyzed based on characters of larvae, pupae, and adults (mainly male genitalia). The genus is monophyletic and most closely related to Psychomyia, and Metalype in the subfamily Psychomyiinae. Nine species groups are suggested. Eight species, including six new to science, are reported from the People's Republic of China for the first time.
In this study the rich variety of fossil microorganisms and other ultrastruchlres in the Messel oil shale is documented. The taphonomy of the micro- and the macro organisms is discussed and a basic model for microbial life in the Eocene Lake Messel is proposed. Documentation of the Messel microbiota was made using a scanning electron microscope fitted with an energy-dispersive X-ray analyzer, and a transmission electron microscope. The most common objects discovered were fossil bacteria in the form of cocci, coccobacilli, bacilli, curved rods and filaments, preserved as moulds, crusts, casts, encrusted casts and clay-coated casts. The main lithifying mineral is apatite, followed by siderite. The bacteria occur on fossil remains of macroorganisms. Sideritic bacteria are usually found on keratinous substrates, whereas apatitic bacteria occur preferentially on fish remains. Lithification of the bacteria was selective. It is suggested that the preserved bacteria were heterotrophic, Gram-positive anaerobes, which may have belonged to the group of clostridians.
Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer and pulmonary LAM, especially during early stages. Herein, we present a case of a 66-year-old man with a small nodule in the right upper lobe that was first diagnosed as a lung malignancy using a chest CT scan. After a wedge dissection, a pathologist performed a histologic and immunohistochemical examination, and a diagnosis of pulmonary LAM was made. We further performed a 518-gene panel analysis using next-generation sequencing, and only three genes, BARD1, BLM, and BRCA2, were found to have mutations. We also provide a summary of the diagnosis and treatment of this disease.
The goals of this exercise are essentially threefold: (1) to rescrutinize, archaeologically, epigraphically and linguistically, the pre-Roman inscriptions of the justly famous Negau A and B helmets, (2) to identify "eastward graphemic drift" in preRoman northern Italy and (3) to reconsider and perhaps identify the origin of the Germanic runes in light of (1) and (2). While moving toward these goals, we cite but a sampling of the burgeoning literature, some of which may not be generally known or easily accessible, in these rapidly expanding venues; see Ellis (1998) for a recent overview in English.
The Sclerocoelus galapagensis group is defined and revised, including the description of S. galapagensis new species from the Galapagos Islands; S. caribensis new species from the Caribbean and adjacent areas; S. brasilensis new species from Brazil, Ecuador, Colombia, and Panama; S. hemorrhoidal is new species from Ecuador and Venezuela; and S. andensis new species from Argentina, Bolivia, and Venezuela. The south Atlantic species Sclerocoelus subbrevipennis (Frey), new combination, is redescribed as a member of the S. galapagensis group, and is considered the sister species to the rest of the species group. A key to species, character matrix, and cladogram are provided.
The bromodomain and PHD-finger containing transcription factor (BPTF) is part of the nucleosome remodeling factor (NURF) complex and has been implicated in multiple cancer types. Here, we report the discovery of a potent and selective chemical probe targeting the bromodomain of BPTF with an attractive pharmacokinetic profile enabling cellular and in vivo experiments in mice. Microarray-based transcriptomics in presence of the probe in two lung cancer cell lines revealed only minor effects on the transcriptome. Profiling against a panel of cancer cell lines revealed that the antiproliferative effect does not correlate with BPTF dependency score in depletion screens. Both observations and the multi-domain architecture of BPTF suggest that depleting the protein by proteolysis targeting chimeras (PROTACs) could be a promising strategy to target cancer cell proliferation. We envision that the presented chemical probe and the related negative control will enable the research community to further explore scientific hypotheses with respect to BPTF bromodomain inhibition.
This paper proposes a new sound rule for Proto-Slavic, according to which *g (from PIE *g, *gw, *gh, and *gwh) was lost before *m. This development was posterior to Winter’s law and the merger of voiced and aspirated stop in Slavic. The operation of the rule is illustrated by new etymologies of four Slavic words: *ama, *jama ‘hole, pit’, *těmę ‘sinciput’, *mąžь ‘husband, man’, and *remy ‘leather belt’.
Giulio Camillo (1480 - 1544) was as well-known in his era as Bill Gates is now. Just like Gates he cherished a vision of a universal Storage and Retrieval System, and just like Microsoft Windows, his ‘Theatre of the Memory’ was, despite constant revision, never completed. Camillo’s legendary Theatre of Memory remained only a fragment, its benefits only an option for the future. When it was finished, the user - so he predicted - would have access to the knowledge of the whole universe. On account of his promising invention, Camillo’s contemporaries called him ‘the divine’. For others, like Erasmus or the Parisian scholars, he was just a ‘quack’, but also this only shows that his reception was as strong as is the case with the computer gurus of our days. Still, Camillo was forgotten immediately after his death. No trace is left of his spectacular databank - except a short treatise which he dictated on his deathbed and which was formulated in the future tense: ‘L’Idea del Theatro’ (1550). ...
In the ignorance which still prevails regarding many details of the breeding-habits of the Cuckoo, we have a goof object lesson of how well Nature is able to guard her secrets, since, after years of careful and methodical investigation by distinguished naturalists, comparatively few authentic facts have been established. ...
Covalent inhibition has become more accepted in the past two decades, as illustrated by the clinical approval of several irreversible inhibitors designed to covalently modify their target. Elucidation of the structure-activity relationship and potency of such inhibitors requires a detailed kinetic evaluation. Here, we elucidate the relationship between the experimental read-out and the underlying inhibitor binding kinetics. Interactive kinetic simulation scripts are employed to highlight the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby showcasing which assumptions and corrections are crucial. Four stepwise protocols to assess the biochemical potency of (ir)reversible covalent enzyme inhibitors targeting a nucleophilic active site residue are included, with accompanying data analysis tailored to the covalent binding mode. Together, this will serve as a guide to make an educated decision regarding the most suitable method to assess covalent inhibition potency. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.
This paper aims to compile an exhaustive list of the behavioral patterns exhibited by the chimpanzees of the Mahale Mountains National Park, Tanzania. The compilation is based on the glossary compiled by Goodall (1989), but a substantial numbers of new terms have been added. Thus, we list 316 simple anatomical terms, 81 complex anatomical terms, 37 simple functional terms, and 81 complex functional terms, in addition to 116 synonyms. The behavioral patterns are divided into eight categories on the basis of degree of universality: (1) commonly seen in both Homo and two species of Pan, (1?) commonly seen in Homo and only one species of Pan, (2) patterns common to the genus Pan but not to Homo, (3) patterns common to the chimpanzee Pan troglodytes but not the bonobo Pan paniscus, (4) patterns common to eastern (P.t. schweinfurthii) and central (P.t. troglodytes) but not western (P.t. vents) chimpanzees, (5) patterns unique to the eastern chimpanzees, P.t. schweinfurthii, (6) patterns unique to the population of Mahale, (7) patterns unique to many individuals (at least most members of an age/sex class) of M group chimpanzees, (8) patterns limited to a single (idiosyncrasy) or a few individuals of M group. It is most likely that the behavior patterns of the last common ancestor of Homo and Pan are found in Categories 1 and I? and less likely in Categories 2 and 3. It is possible that behavior patterns belonging to Categories 5, 6 or 7 are cultures.
During the 1930s through the 1940s and into the 1950s, Spanish and German presentations in opposition to ardent nationalism share strikingly common aesthetic and ideological strategies supporting claims to a transnational, international space. Specific examples of common geography, identity and language in German and Spanish presentations (theater, short stories, reports, essays, speeches and poetry) in Spain and Latin America by German (Regler, Renn, Uhse), Spanish (J. Bergamin, R. Alberti, M. Aub) and Latin American (D. Rivera, P. Neruda, C. Vallejo) intellectuals, artists and activists during the 1930s through the 1950s will be explored. For example, German-speaking audiences and artists in Spain and Mexico shared a common lived and aesthetic space as Spanish-speaking audiences and artists. Further, many German presentations were translated into Spanish and visa versa. Here, presentations in “Das Wort” and “El Mono Azul” in Spain as well as “Freies Deutschland/Alemania libre” in Mexico will be referenced in developing a sense of re-definition of the concept of ‘foreign’ and ‘commonness’ beyond simply nationality (tradition, history and geography) and language. The impetus for an alternative, international and even revolutionary ‘space’ (as defined by Henri Lefebvre in The Production of Space) was produced in and through common Spanish and German strategies and realizations in their presentations. This Spanish-German example from the early/mid-part of the 20th century is a significant contribution to contemporary interdisciplinary discussions in the 21st century.
The shape of the facial carina in Altastreplia is discussed. Although taxonomically useful, the protrudent form probably occurs by convergence in different species groups. Two species groups in which the carina is usually produced are revised. The belljamini species group includes: belljamini Lima (from southeastern Brazil), gigantea Stone (from Panama), magna, n. sp. (from Colombia and Venezuela), and superj1ua Stone (from Panama). Host data for this group are limited to only one record of benjamilli from a species of Pouteria (Sapotaceae). The pallidipennis complex, which is included in the pseudoparallela species group, is recognized to include: amnis Stone (from southern Brazil and possibly Trinidad), curitis Stone (from Colombia, Peru, and northern Brazil), pallida, n. sp. (from Panama), pallidipennis Greene (from Colombia and Venezuela), and vele::i, n. sp. (from Colombia). These species breed in fruit of Passij10ra (Passifloraceae) (P. ambigua Hems., ligularis Juss., Idtida H.B.K., quadrallgularis L., and seemannii Griseb.). The relationships of these Anastrepliaspecies are discussed, and diagnoses and ill ustrations are provided to permit their identification. A neotype is designated for A. consobrina (Loew), and the identity of this species is clarified.
Extremely short verbs can be found in various Genn::.,nic languages and dialects; the sterns of these verbs do not have a fInal consonant «C-)C-V), and they always have a monosyllabic infinitive and usually monosyllabic fInite forms as weIl. Examples for these 'kinds of short verbs are Swiss Gennan hä 'to have', gö 'to go', g~ 'to give', n~ 'to take' which correspond to the Swedish verbs ha, gä, ge and tao The last example shows that such short verb formations also occur with verbs having (nearly) identical meanings but which do not share the same etymology. Apart from their shortness, these verbs are characterized by a high degree of irregularity, often even by suppletion, which sometimes develops contrary to regular sound laws. Furthermore they are among the most-used verbs and often tend towards grammaticalization. The present paper compares the short verbs of seven Germanic languages; in addition, it describes their various ways of development and strategies of differentiation. Moreover, it examines the question of why some languages and dialects (e.g. Swiss German, Frisian, Swedish, Norwegian) have many short verbs while others (New High German, Icelandic, Faroese) only have few, the paper discusses the contribution of short verbs to questions concerning linguistic change and the morphological organization of languages.
In order to understand the specific structures and features of the German surnames the most important facts about their emergence and history should be outlined and, at the same time, be compared with the Swedish surnames because there are considerable differences (for further details cf. Nubling 1997 a, b). First of all, surnames in Germany emerged rather early, with the first instances occurring in the 11th century in southern Germany; by the 16th century surnames were common all over Germany. Differences are related to geography (from south to north), social class (from the upper to the lower classes) und urban versus rural areas.
German linking elements are sometimes classified as inflectional affixes, sometimes as derivational affixes, and in any case as morphological units with at least seven realisations (e.g. -s-, -es-, -(e)n-, -e-). This article seeks to show that linking elements are hybrid elements situated between morphology and phonology. On the one hand, they have a clear morphological status since they occur only within compounds (and before a very small set of suffixes) and support the listener in decoding them. On the other hand, they also have to be analysed on the phonological level, as will be shown in this article. Thus, they are marginal morphological units on the pathway to phonology (including prosodics). Although some alloforms can sometimes be considered former inflectional endings and in some cases even continue to demonstrate some inflectional behaviour (such as relatedness to gender and inflection class), they are on their way to becoming markers of ill-formed phonological words. In fact, linking elements, above all the linking -s-, which is extremely productive, help the listener decode compounds containing a bad phonological word as their first constituent, such as Geburt+s+tag ‘birthday’ or Religion+s+unterricht ‘religious education’. By marking the end of a first constituent that differs from an unmarked monopedal phonological word, the linking element aids the listener in correctly decoding and analysing the compound. German compounds are known for their length and complexity, both of which have increased over time—along with the occurrence of linking elements, especially -s-. Thus, a profound instance of language change can be observed in contemporary German, one indicating its typological shift from syllable language to word language.
The (mis)management of rapport amongst groups in Niger Delta (ND) communities has become a significant issue, which Ahmed Yerima's Hard Ground (HG) depicts as having the capacity to aid or control the conflicts in the region. Linguistic studies on Yerima's drama from the perspective of pragmatics have tended to use pragmatic acts to identify the discourse value of proverbs and functions of characters' utterances but have not accounted for the politeness strategies utilised for rapport management, especially in conflict situations. This article, drawing on a rapport management model of politeness and aspects of speech act discourse, identifies the face, sociality rights, and interactional goals that characterise the conflict-motivated dialogues sampled in HG, and reveals the rapport management (RM) strategies through which these are managed in the text. Three conflict situations can be observed as prompting different RM strategies: cause-effect identification (CEI), militancy support (MSP), and disagreement (DSG) situations. CEI is marked by incriminating (involving eliciting and informing acts) and exonerating (including complimenting and acknowledging acts) strategies; MSP is indexed by strategies of persuasion (realised with face-enhancing/threatening acts), whereas DSG is typified by requesting (featuring explicit head acts and alerters) and blaming strategies (including insulting and threatening, aggravating moves). Generally, the requesting, blaming, and exonerating strategies are largely used by the ND youth in HG to probe, threaten, or disagree on specific issues, while the incriminating and persuasion strategies are mainly employed by the women to indict, influence, and predict future actions. The study of RM in the conflict situations depicted in the play sheds light on the often neglected cause of conflicts in contemporary Africa.
The subfamily Epiphloeinae is defined to include fourteen genera as follows: Epiphloeus Spinola; Pilosirus, new genus; Plocamocera Spinola; Iontoclerus, new genus; Arenaria, new genus; Ichnea Laporte; Diapromeces, new genus; Pyticeroides Kuwert; Ellipotoma Spinola; J{atamyurus, new genus; Megatrachys, new genus; Madoniella Pic; Hapsidopteris, new genus; and Teutonia, new genus. The following type-species are described: Pilosirus brunoi, new species; Arenaria chiapas, new species; Diapromeces aclydis, new species; Katamyurus paxillus, new species; Megatrachys paniculus, new species; Hapsidopteris diastenus, new species; and Teutonia nova, new species. Elloplium humerale Klug is designated as the typespecies of Iontoclerus. The genus Madolliella is removed from the subfamily Korynetinae andis declared a senior synonym of Phlogistosternus Wolcott. Neiclmea is synonymized with Pyticeroides. This treatise includes a key to the genera of Epiphloeinae, descriptions of the genera and new type-species, and distribution map for each genus.