Article
Refine
Year of publication
- 2019 (500) (remove)
Document Type
- Article (500) (remove)
Has Fulltext
- yes (500)
Is part of the Bibliography
- no (500)
Keywords
- inflammation (10)
- glioblastoma (8)
- cancer (7)
- Breast cancer (6)
- biomarker (6)
- Inflammation (5)
- breast cancer (5)
- immunotherapy (5)
- mTOR (5)
- Biomarkers (4)
- Chemotherapy (4)
- Gene expression (4)
- Human behaviour (4)
- Oncology (4)
- autophagy (4)
- cirrhosis (4)
- fMRI (4)
- glioma (4)
- hypoxia (4)
- infection (4)
- invasion (4)
- macrophage (4)
- microRNA (4)
- mitochondria (4)
- Aortic valve (3)
- Cancer treatment (3)
- Children (3)
- Cirrhosis (3)
- Death rates (3)
- Depression (3)
- Drug therapy (3)
- Germany (3)
- HDAC (3)
- Hemorrhage (3)
- Immunotherapy (3)
- Mental health and psychiatry (3)
- Molecular neuroscience (3)
- Multivariate analysis (3)
- Neutropenia (3)
- Outcome (3)
- Predictive markers (3)
- Prognosis (3)
- Prävention (3)
- Quality of life (3)
- Research article (3)
- T cells (3)
- acute coronary syndrome (3)
- angiogenesis (3)
- complications (3)
- cytokines (3)
- differentiation (3)
- efficacy (3)
- epilepsy (3)
- integrin (3)
- leukemia (3)
- macrophage polarization (3)
- macrophages (3)
- monocytes (3)
- mycophenolic acid (3)
- neoadjuvant therapy (3)
- p21 (3)
- peripheral artery disease (3)
- prevention (3)
- reactive oxygen species (3)
- risk factors (3)
- sepsis (3)
- surgery (3)
- tumor microenvironment (3)
- vitamin D (3)
- Acute inflammation (2)
- Acute myeloid leukemia (2)
- Adverse events (2)
- Age groups (2)
- Alpelisib (2)
- Apoptosis (2)
- Aspergillus fumigatus (2)
- Atezolizumab (2)
- B cells (2)
- Biomarker (2)
- Body mass index (2)
- CAD/CAM (2)
- CC16 (2)
- CDKN1A (2)
- CIK cells (2)
- Cancer (2)
- Cancer chemotherapy (2)
- Cancer genomics (2)
- Cardiac hypertrophy (2)
- Cell differentiation (2)
- Cell proliferation (2)
- Clinical presentation (2)
- Cognition (2)
- Crohn’s disease (2)
- Cytokines (2)
- DMEK (2)
- DNA methylation (2)
- Developmental biology (2)
- Diagnostic medicine (2)
- Digestive system procedures (2)
- EGFR (2)
- Ears (2)
- Ejection fraction (2)
- Endothelial cells (2)
- Epidemiology (2)
- Fatty liver (2)
- HBV (2)
- HSV (2)
- Heart (2)
- Heart failure (2)
- Hepatitis C virus (2)
- Hospitals (2)
- Hypertension (2)
- IBD (2)
- Incidence (2)
- Infectious diseases (2)
- Inflammatory diseases (2)
- Ischemia (2)
- Katherine (2)
- Knowledge (2)
- Liver diseases (2)
- MYC (2)
- Machine learning (2)
- Macrophages (2)
- Magnetic resonance imaging (2)
- Mammakarzinom (2)
- Mesenchymal stem cells (2)
- Messenger RNA (2)
- Metastasen (2)
- Molecular medicine (2)
- Mouse (2)
- NADPH oxidase (2)
- Obesity (2)
- Ophthalmology (2)
- Outcomes (2)
- PARP (2)
- PD-L1 (2)
- PD‑L1 (2)
- PI3K (2)
- Patients (2)
- Pediatric infections (2)
- Personalized medicine (2)
- Pregnancy (2)
- Psychiatric disorders (2)
- RITA (2)
- Radiomics (2)
- Sepsis (2)
- Sleep (2)
- Stroke (2)
- Suicide (2)
- Supportivtherapie (2)
- Surgery (2)
- Surgical and invasive medical procedures (2)
- Surgical oncology (2)
- Transcription factors (2)
- Treatment (2)
- T‑DM1 (2)
- additives (2)
- adjuvant therapy (2)
- adjuvante Therapie (2)
- advanced (2)
- aged (2)
- alirocumab (2)
- alpelisib (2)
- antiviral therapy (2)
- apoptosis (2)
- arteriogenesis (2)
- astrocytes (2)
- atezolizumab (2)
- attention (2)
- bone metabolism (2)
- brain metastases (2)
- caspase-2 (2)
- cholesterol (2)
- chronic kidney disease (2)
- classical Hodgkin lymphoma (2)
- cognition (2)
- colorectal cancer (2)
- complement (2)
- corneal edema (2)
- corneal transplantation (2)
- curcumin (2)
- cyclosporin A (2)
- cytomegalovirus (2)
- data science (2)
- dementia (2)
- dental implant (2)
- early breast cancer (2)
- echocardiography (2)
- eicosanoids (2)
- electrolytic cleaning (2)
- environmental tobacco smoke (2)
- extracellular matrix (2)
- fortgeschritten (2)
- frühes Mammakarzinom (2)
- graph theory (2)
- heart failure (2)
- hematopoietic stem cell transplantation (2)
- hepatitis C virus (2)
- human (2)
- immune evasion (2)
- innate immunity (2)
- integrins (2)
- liver disease (2)
- lncRNA (2)
- magnetic resonance imaging (2)
- metabolic syndrome (2)
- metastatic (2)
- methylprednisolone (2)
- migration (2)
- modularity (2)
- mortality (2)
- multiple sclerosis (2)
- music (2)
- neoadjuvante Therapie (2)
- obesity (2)
- osteoporosis (2)
- particulate matter (2)
- periimplantitis (2)
- pharmacovigilance (2)
- phosphorylation (2)
- portal hypertension (2)
- primary care (2)
- primary health care (2)
- proliferation (2)
- prostaglandins (2)
- prostate cancer (2)
- proteome (2)
- proteomics (2)
- psoriasis (2)
- quantitative MRI (2)
- radical prostatectomy (2)
- radiotherapy (2)
- registry (2)
- renal function (2)
- secretome (2)
- signal transduction (2)
- sphingosine-1-phosphate (2)
- supportive therapy (2)
- targeted therapy (2)
- transplantation (2)
- trauma (2)
- tumor-associated macrophages (2)
- uteroglobin (2)
- (novel) brominated flame retardants ((N)BFR) (1)
- (surface) partial differential equations (1)
- 15-PGDH (1)
- 3Cs technology (1)
- 3D spatiotemporal resolved mathematical models (1)
- 3D tissue models (1)
- 3years (1)
- 5' UTR (1)
- 6-Schritt-Methode (1)
- A375 human melanoma cell line (1)
- AB-serum (1)
- ACL (1)
- ACLF (1)
- AICAR (1)
- AIS (1)
- ALF (1)
- AMD3100 (1)
- AML (1)
- AMPK (1)
- APRI (1)
- ASCT (1)
- AT-101 (1)
- ATG4 (1)
- ATG8 (1)
- ATM (1)
- ATO (1)
- AVM hemorrhage (1)
- Abdominal surgery (1)
- Abdominal trauma (1)
- Abiraterone acetate (1)
- Actinomycin D (1)
- Action potential (1)
- Addison’s disease (1)
- Adenocarcinoma (1)
- Adhesins (1)
- Adhesion (1)
- Adipose-derived mesenchymal stem cells (1)
- Adjustment of dosage at steady state (1)
- Adolescents (1)
- Agoraphobia (1)
- Akutes Koronarsyndrom (1)
- Alleles (1)
- Allergen immunotherapy (1)
- Allergoid (1)
- Aminotransferases (1)
- Anemia (1)
- Anesthesia, Intravenous (1)
- Aneurysmal subarachnoid hemorrhage (1)
- Aneurysms (1)
- Angiogenesis (1)
- Angiography (1)
- Anosmia (1)
- Antibody isotypes (1)
- Anticoagulants [MeSH] (1)
- Anticoagulation (1)
- Antigen-presenting cells (1)
- Antigens (1)
- Antiplatelet therapy (1)
- Antireflux surgery (1)
- Antiviral therapy (1)
- Anura (1)
- Aortic aneurysm (1)
- Aortic arch replacement (1)
- Aortic dissection (1)
- Aortic stenosis (1)
- Aortic stiffness (1)
- Aortic valve replacement (1)
- Aortic valve sparing (1)
- Apes (1)
- Arabin pessary (1)
- Arabin-Pessar (1)
- ArchT (1)
- Aromatase Inhibitors (1)
- Arrhythmia (1)
- Artificial intelligence (1)
- Aspergillus species (1)
- Asphyxia (1)
- Ataxia telangiectasia (1)
- Atelopus carbonerensis (1)
- Atelopus mucubajiensis (1)
- Atelopus tamaense (1)
- Atrial fibrillation (1)
- Attention (1)
- Attitude (1)
- Audio equipment (1)
- Audio signal processing (1)
- Audiology (1)
- Aurora A (1)
- Aurora Ax (1)
- Australia (1)
- Austria (1)
- Automated sRNA analysis (1)
- Autophagy (1)
- Awareness (1)
- Axon (1)
- B cell malignancies (1)
- B cell precursor acute lymphoblastic leukemia (1)
- B-cell antigen receptor (1)
- BBB (1)
- BCL2 (1)
- BI1361849 (1)
- BIAM switch assay (1)
- BMAC (1)
- BNC2 (1)
- BRAF mutation (1)
- Back pain (1)
- Bartonella (1)
- Biliary tree (1)
- Bilirubin (1)
- Biomarkers & Diagnostic Imaging (1)
- Biotechnology (1)
- Bipolar disorder (1)
- Blood (1)
- Blood groups (1)
- Blood plasma (1)
- Blood pressure (1)
- Blood-brain barrier (1)
- BluePrint (1)
- Body-contouring surgery (1)
- Bone marrow (1)
- Bone marrow aspirate concentrate (1)
- Bone marrow aspiration (1)
- Bone strength assessment (1)
- Borrelia (1)
- Brain metastasis (1)
- Breast neoplasms (1)
- Breast tumors (1)
- Bufonidae (1)
- Burst (1)
- C-reactive protein (1)
- C-reactive proteins (1)
- C1 esterase inhibitor (human) (1)
- C1-esterase inhibitor protein (1)
- C3M (1)
- C4M (1)
- CAM (1)
- CD271 (1)
- CD3/CD19 depletion (1)
- CD36 (1)
- CD45RA naïve lymphocytes (1)
- CD8+ T lymphocytes (1)
- CD8+ tumor infiltrating lymphocytes (1)
- CHA2DS2-VASc-score (1)
- CHIP (1)
- CLP (1)
- CREB inhibitor (1)
- CRISPR/Cas (1)
- CRM (1)
- CRT-D (1)
- CTLA-4 (1)
- CV9202 (1)
- CVD biomarker (1)
- CVID (1)
- CWS Studiengruppe (1)
- CXCL12 (1)
- Caco-2 cells (1)
- Canada (1)
- Cancer detection and diagnosis (1)
- Cancer epidemiology (1)
- Cancer genetics (1)
- Cancer risk factors (1)
- Cancer therapeutic resistance (1)
- Cannabis (1)
- Carcinoma, Ductal, Breast (1)
- Cardiac device therapy (1)
- Cardiac monitoring (1)
- Cardiac necroenzymes (1)
- Cardiac remodelling (1)
- Cardiology (1)
- Cardiovascular Magnetic Resonance (CMR) (1)
- Cardiovascular epidemiology (1)
- Case management [MeSH] (1)
- Cell binding (1)
- Cell biology (1)
- Cell motility (1)
- Cell therapy (1)
- Cellular stress responses (1)
- Center-specific time in therapeutic range (cTTR) (1)
- Central nervous system metastases (1)
- Cerebral toxoplasmosis HIV (1)
- Cerebral vasospasm (1)
- Cesarean section (1)
- Chaperone (1)
- Chemical company (1)
- Chemosensitivity (1)
- Chlorides (1)
- Cholesterin (1)
- Chromatin accessibility (1)
- Chronic disease [MeSH] (1)
- Chronic health condition (1)
- Chronic hepatitis (1)
- Chronic hepatitis C virus (1)
- Chronic kidney disease (1)
- Chronic obstructive pulmonary disease (1)
- Citation analysis (1)
- Clincial pharmacology (1)
- Clinical effectiveness (1)
- Clinical pathways (1)
- Clinical studies (1)
- Clinical trial (1)
- Clostridioides difficile (1)
- Cognitive impairment (1)
- Cognitive neuroscience (1)
- Cognitive psychology (1)
- Colchicum (1)
- Collagen (1)
- Collagens (1)
- Colloids (1)
- Colorectal cancer (1)
- Combined immune checkpoint blockade (1)
- Community based intervention (1)
- Community health services (1)
- Comparative analysis (1)
- Complement cascade (1)
- Complication management (1)
- Comprehensive cancer centers (1)
- Computational biology and bioinformatics (1)
- Computational model (1)
- Computational sRNA analysis (1)
- Conduct disorder (1)
- Congenital duodenal obstruction (1)
- Contrast-enhanced (1)
- Cornea (1)
- Coronary heart disease (1)
- Cost-effectiveness (1)
- Cost-effectiveness analysis (1)
- Costs (1)
- Crispr/Cas (1)
- Cross-frequency coupling (1)
- Cross-sectional study (1)
- Cumulative dose (1)
- Cure (1)
- Curvilinear dose response (1)
- Cytochrome P450 enzymes (1)
- Cytogenetics (1)
- Cytoplasm (1)
- Cytoplasmic staining (1)
- Cytoskeletal proteins (1)
- Cytoskeleton (1)
- C‐reactive protein (1)
- DDA (1)
- DDIT4 (1)
- DHA (1)
- DILI (1)
- DME (1)
- DNA damage (1)
- DNA damage response (1)
- DNA repair (1)
- DNA-binding proteins (1)
- DNase1-seq (1)
- DSAEK (1)
- DUBs (1)
- Data mining (1)
- Data processing (1)
- Data science (1)
- David technique (1)
- Decision (1)
- Decision impact (1)
- Decision trees (1)
- Delayed union (1)
- Deletion mutation (1)
- Dental education (1)
- Dental students (1)
- Diagnosis (1)
- Diagnostic markers (1)
- Diagnostic test (1)
- Direct Acting Antivirals (DAA) (1)
- Direct acting antiviral therapies (1)
- Disabling back pain (1)
- Disease burden (1)
- Docetaxel (1)
- Dog (1)
- Dopamine (1)
- Dorsolateral prefrontal cortex (1)
- Doxorubicin (1)
- Dual energy CT (1)
- Duodenal atresia (1)
- Duodenal stenosis (1)
- E protein structure (1)
- EEG (1)
- EGFP (1)
- EGFR inhibitor (1)
- ENCODE-DREAM in vivo Transcription Factor binding site prediction challenge (1)
- EPA (1)
- ERK3/MAPK6 (1)
- ERM (1)
- ERP (1)
- Economic analysis (1)
- Economics (1)
- Edentulous jaw (1)
- Education (1)
- Eicosanoids (1)
- Einreibetechnik (1)
- Electrical accident (1)
- Electrical stimulation (1)
- Electroencephalography – EEG (1)
- Electrolytes (1)
- Electrophysiology (1)
- Emergency (1)
- Emotion processing (1)
- Emotion regulation (1)
- Emotions (1)
- Empfehlungen (1)
- Employment (1)
- EndMT (1)
- Endoscopy (1)
- Ensemble learning (1)
- Enterobacteriaceae (1)
- Entfernung (1)
- Enzyme regulation (1)
- Enzyme-linked immunoassays (1)
- Epilepsy (1)
- Erythropoiesis (1)
- Esophageal adenocarcinoma (1)
- Esophageal adenocarcinoma (EAC) (1)
- Esophagectomy (1)
- Estrogen Receptor Modulators (1)
- Eukaryotic sRNA (1)
- Europe (1)
- European Society for Immunodeficiencies (ESID) (1)
- Evaluation (1)
- Evaluationspraxis (1)
- Evidence based medicine (1)
- Exercise challenge at an ambient temperature (1)
- Exercise challenge in a cold chamber (1)
- Exercise-induced bronchoconstriction (1)
- Experimental models of disease (1)
- Extended Glasgow outcome scale (eGOS) (1)
- Extracellular matrix proteins (1)
- Extracellular signal-regulated kinase 1/2 (1)
- Eyes (1)
- FAK (1)
- FFLU (1)
- FFPE (1)
- FIB-4 (1)
- Fatty acids (1)
- FemNAT-CD (1)
- Female adolescents (1)
- Femoral neck (1)
- Fevers (1)
- Fibroblast growth factor (1)
- Fibronectin (1)
- Fibrosis (1)
- Filovirus cell entry; attachment factors redundancy; SH-SY5Y cell line; host–pathogen interactions (1)
- Finite Volumes (1)
- First site of metastatic disease (1)
- Fistula (1)
- Flaps (1)
- Fluorescence-in-situ-hybridization (FISH) (1)
- Foramen ovale (1)
- Forkhead box (1)
- Fracture risk (1)
- Francisella tularensis (1)
- Francisella tularensis subspecies holarctica (1)
- Frühgeburt (1)
- Functional electrical stimulation (1)
- Functional magnetic resonance imaging (1)
- Functional outcome (1)
- Funding (1)
- FungiScope® registry (1)
- G-protein (1)
- G/P (1)
- GRK2 (1)
- Gait analysis (1)
- Galleria mellonella (1)
- Gastric cancer (1)
- Gastroesophageal reflux disease (1)
- Gastroesophageal reflux disease symptoms (1)
- Gaucher disease type III (1)
- Gaucher’s disease (1)
- Gender reassigning surgery (1)
- Gene prediction (1)
- Gene regulation (1)
- General practice (1)
- General practitioner (1)
- General practitioners (1)
- Generation Y (1)
- Genome annotation (1)
- Genomic instability (1)
- German PID-NET registry (1)
- German people (1)
- Gleason upgrading (1)
- Glioblastoma (1)
- Global health (1)
- Glomerular Filtration Rate (1)
- Glucose Transporter Type 1 (1)
- Glycogen synthase kinase 3 beta (1)
- Goserelin (1)
- Grafts (1)
- Gram-negative bacteria (1)
- Grass pollen (1)
- Growth factors (1)
- Guided surgery (1)
- HAEGARDA (1)
- HAI‐1 (1)
- HCV (1)
- HDACi (1)
- HER2/neu (ERBB2) (1)
- HGF (1)
- HIF1α (1)
- HIV (1)
- HNSCC (1)
- HOD (1)
- HODE (1)
- HPV (1)
- HSV-1 (1)
- HSV-2 (1)
- HUVEC (1)
- Haplotypes (1)
- Head and neck Cancer (1)
- Health care (1)
- Health economics (1)
- Health services research [MeSH] (1)
- Healthcare worker (1)
- Hedgehog (1)
- Hemoglobin (1)
- Hemophilia A (1)
- Hemorrhagic shock (1)
- HepG2 (1)
- HepaRG cells (1)
- Hepatitis B (1)
- Hepatitis B infection (1)
- Hepatitis B vaccination (1)
- Hepatitis C (1)
- Hepatocytes (1)
- Hereditary angioedema (1)
- High-risk patient (1)
- Hippo signaling (1)
- Hippocampus (1)
- Histology (1)
- Hodgkin lymphoma (1)
- Holmes tremor (1)
- Homeostasis (1)
- Homicide (1)
- Hospitalizations (1)
- Host-directed therapies (1)
- Huh7 (1)
- Human (1)
- Human genetics (1)
- Human olfaction (1)
- Humeral fractures (1)
- Humerus (1)
- Hungary (1)
- Hydrocephalus (1)
- Hyperammonemic encephalopathy (1)
- Hypofractionated radiotherapy (1)
- Hypoxic responses (1)
- I-FABP (1)
- ICU (1)
- IGF (1)
- IL-15 (1)
- IL-1β (1)
- IL-21 (1)
- IL-27 cytokine (1)
- IL-33 (1)
- IL10R (1)
- ILUVIEN (1)
- IPEX (1)
- IPS e.max system (1)
- ISS (1)
- IUIS classification 2017 (1)
- IgE (1)
- IgG substitution therapy (1)
- IgGAM (1)
- Illumina (1)
- Image analysis (1)
- Imaging genetics (1)
- Immediate loading (1)
- Immediate placement (1)
- Immune Response (1)
- Immune cells (1)
- Immunoassays (1)
- Immunogenicity (1)
- Immunohistochemistry (1)
- Immunohistochemistry techniques (1)
- Immunomonitoring (1)
- Immunostaining (1)
- Immunosuppressive Agents (1)
- Implant-supported bars (1)
- In-line filtration (1)
- IncL (1)
- Incidence rate (1)
- Independent laboratories (1)
- Indirect-binding (1)
- Individual differences (1)
- Infarction (1)
- Infusion management (1)
- Insulin resistance (1)
- Integrated multimodal training (1)
- Intelligence (1)
- Intelligence tests (1)
- Intensive care (1)
- Intensive care units (1)
- Interleukin-17A (1)
- Interleukin-18 (1)
- Interleukin-18 binding protein (1)
- Interleukin-22 (1)
- Interleukin-22 binding protein (1)
- Interventional Trials (1)
- Interventional cardiology (1)
- Intracranial embolism (1)
- Intraoral scanners (1)
- Invasive fungal infection (1)
- Invasive fungal infections (1)
- Ipilimumab (1)
- Ireland (1)
- Iron deficiency (1)
- Iron deficiency anemia (1)
- JAK inhibition (1)
- Joint loading (1)
- KIF (1)
- KIF11 (1)
- Karyotypes (1)
- Ketogenic Diet (1)
- L-DOPA (1)
- LAMTOR2 (1)
- LC-NE system (1)
- LC3 I/II (1)
- LC–MS/MS (1)
- LDL (1)
- LM11A 31 (1)
- LN229 (1)
- LPP (1)
- LRBA (1)
- LSCC (1)
- LSD1 (1)
- LUT (1)
- Labor and delivery (1)
- Laboratory techniques and procedures (1)
- Lafora disease (1)
- Laminin (1)
- Laparoscopic fundoplication (1)
- Late Gadolinium Enhancement (LGE) (1)
- Late presentation (1)
- Left hemisphere (1)
- Leg alignment (1)
- Legs (1)
- Leistungsorientierte Mittelvergabe (1)
- Lesion (1)
- Lesions (1)
- Liver (1)
- Liver Transplantation (1)
- Liver cancer (1)
- Liver fibrosis (1)
- Liver-Related Complications (1)
- Lomentospora prolificans (1)
- Long noncoding RNA (1)
- Long term output (1)
- Long-term (1)
- Luciferase (1)
- Lumbar spine (1)
- Lyme disease (1)
- Lymph nodes (1)
- Lymphadenopathy (1)
- Lymphangioleiomyomatosis (1)
- Lymphocytes (1)
- Lymphoid tissues (1)
- Lymphomas (1)
- Lysosomal storage disease (1)
- MAIT cell (1)
- MALAT1 (1)
- MEG (1)
- MMP2 (1)
- MRI patterns of gliomas (1)
- MRSA (1)
- Machine-learning (1)
- Magnetic resonance imaging (MRI) (1)
- Malaria prevalence (1)
- MammaPrint (1)
- Mammaplasty (1)
- Markov model (1)
- Masquelet technique (1)
- Mass spectrometry (1)
- Mastectomy (1)
- Maxillary sinus (1)
- Mechanisms of disease (1)
- Meckel’s diverticulum (1)
- Medical education (1)
- Medical research (1)
- Medicine and health sciences (1)
- Membrane potential (1)
- Mesenchymal stem cell (1)
- Mesenchymal stromal cells (1)
- Metabolic syndrome (1)
- Metabolism (1)
- Metabolism, Inborn Errors (1)
- Metalloproteases (1)
- Metastasis (1)
- Metastatic castration-resistant prostate cancer (1)
- Metastatic tumors (1)
- Methacholine challenge test (1)
- Methicillin-resistant Staphylococcus aureus (1)
- MiSpEx Network (1)
- MicroRNAs (1)
- Microbiome (1)
- Microphones (1)
- Molecular profiling (1)
- Molecular signatures (1)
- Molecular subtype (1)
- Molecular subtypes (1)
- Monosaccharide Transport Proteins (1)
- Monte Carlo simulation (1)
- Morbidity (1)
- Morphogenesis (1)
- Motor control (1)
- Mouse models (1)
- Mucopolysaccharidoses (1)
- Multi-nucleated cardiomyocytes (1)
- Multidrug-resistant tuberculosis (1)
- Multinomial logistic regression (1)
- Multivariable analysis (1)
- NASH (1)
- NCH93 (1)
- NDR1 (1)
- NDUFAF8 (1)
- NEAT1 (1)
- NEAT2 (1)
- NGS (1)
- NK cell (1)
- NK cells (1)
- NK-92 (1)
- NKG2D (1)
- NKT cell (1)
- NMDA IgA/IgM antibodies (1)
- NMDA antibody (1)
- NMDAR subunit GluN2B (1)
- NOTCH1 (1)
- NPSR1 (1)
- NSAIDs (1)
- Nanopore (1)
- Native T1 (1)
- Native T1 mapping (1)
- Nav channel activity (1)
- Nav1.7 (1)
- Neonatal urea cycle disorders (1)
- Neonates (1)
- Network model (1)
- Neuro-ophthalmology (1)
- Neuroimaging (1)
- Neuroscience (1)
- Nivolumab (1)
- Non-REM sleep (1)
- Non-coding RNA (1)
- Non-invasive brain stimulation (1)
- Non-small cell lung cancer (1)
- Nonunion (1)
- Notch (1)
- Nox4 (1)
- Numerical simulation (1)
- OXA-48 (1)
- Occupational medicine (1)
- Olfactory diagnostics (1)
- One health (1)
- Opacity (1)
- Oposterior urethral valve (1)
- Opportunistic infections (1)
- Optical lenses (1)
- Oral Health Impact Profile (OHIP) (1)
- Oral and maxillofacial surgery (1)
- Oral anticoagulation (1)
- Oral implantology (1)
- Oral surgery (1)
- Organ dysfunction (1)
- Oroantral (1)
- Oroantral communication (1)
- Osteogenic differentiation (1)
- Osteoporosis diagnosis (1)
- PCP (1)
- PCSK9 protein (1)
- PEI (1)
- PF-06273340 (1)
- PGE2 (1)
- PID prevalence (1)
- PINK1 (1)
- PKCε (1)
- PLK1 inhibitors (1)
- PPARγ (1)
- Paediatric research (1)
- Pain (1)
- Pancreatic surgery (1)
- Pancreatoduodenectomy (1)
- Panic disorder (1)
- Parapneumonic pleural effusion (1)
- Parkinson disease (1)
- Parkinson’s disease (1)
- Particles (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Patient preferences (1)
- Pause (1)
- Pediatric patients (1)
- Pediatrics (1)
- Pentaglobin (1)
- Peritonitis (1)
- Personalised medicine (1)
- Pharm-fMRI (1)
- Pharmacometrics (1)
- Philadelphia chromosome-positive acute leukemia (1)
- Phylogenetic analysis (1)
- Platelet-rich fibrin (1)
- Platelets (1)
- Platzierung (1)
- Plerixafor (1)
- Pleural empyema (1)
- Pneumocystis jirovecii (1)
- Pneumonia (1)
- Polyunsaturated fatty acids (1)
- Ponatinib (1)
- Portal veins (1)
- Portugal (1)
- Posaconazole serum level (1)
- Positron-emission tomography (1)
- Post treatment (1)
- Precision (1)
- Precision oncology (1)
- Prenatal ultrasonographic detection rate (1)
- Preoperative diagnostics (1)
- Prevalence (1)
- Prevention (1)
- Primary care (1)
- Primary cilium (1)
- Primary health care [MeSH] (1)
- Prisoners (1)
- Prisons (1)
- Profilometry (1)
- Prognostic biomarker (1)
- Prophylaxis (1)
- Prostaglandin (1)
- Prostate-specific membrane antigen (1)
- Prostatic neoplasms (1)
- Protease inhibitor therapy (1)
- Protein translation (1)
- Proteomics (1)
- Proteostasis (1)
- Proton density (1)
- Psychometric evaluation (1)
- Psychometrics (1)
- Quality of care (1)
- Quantitative MRI (1)
- Questionnaires (1)
- REMS (1)
- RNA binding proteins (1)
- RNA extraction (1)
- RNA isolation (1)
- RNAi (1)
- RTS (1)
- RUCAM (1)
- Radiotherapy (1)
- Rare Diseases (1)
- Re-injury (1)
- Reaction time (1)
- Reactive oxygen species (1)
- Real-world evidence (1)
- Recurrence (1)
- Red blood cell transfusion (1)
- Refractory ALL (1)
- Regenerative medicine (1)
- Regression analysis (1)
- Regulatory T cells (1)
- Rehabilitation (1)
- Relapsed ALL (1)
- Relaxometry (1)
- Renal system (1)
- Reproducibility (1)
- Research trends (1)
- Retina (1)
- Retro-IDEAL (1)
- Return to play (1)
- Return to sports (1)
- Rhabdomyosarcoma (1)
- Rheumatoid arthritis (1)
- Rheumatology (1)
- Rho/Rho-kinase (1)
- Ribosomes (1)
- Risk assessment (1)
- Risk prediction (1)
- Roe deer (1)
- Roughness (1)
- Roussel Uclaf Causality Assessment Method (1)
- Roussel Uclaf Causality Assessment Method (RUCAM) (1)
- S1P (1)
- S1PR1 (1)
- SCA34 (1)
- SCA38 (1)
- SHH (1)
- SILAC (1)
- ST2L (1)
- STAT3 (1)
- SUMO1-3 (1)
- SUMOylation (1)
- SUV (1)
- SW480 cells (1)
- SWATH (1)
- Saccades (1)
- Saccadometry (1)
- Safety (1)
- Salivary gland diseases (1)
- Salvage therapy (1)
- Sarcopenia (1)
- Scanner models (1)
- Scedosporium spp. (1)
- Screening (1)
- Screening guidelines (1)
- Secondary prevention (1)
- Seizure (1)
- Sensory perception (1)
- Sensory systems (1)
- Sequence motif analysis (1)
- Serine proteases (1)
- Serotype 3 (1)
- Severe bacterial infection (1)
- Sex differences (1)
- Signal transduction (1)
- Single-cell RNA-sequencing (1)
- Small RNA analysis (1)
- Smooth muscle cells (1)
- Social epidemiology (1)
- Social health determinants (1)
- Social participation (1)
- Somatization (1)
- Specimen preparation and treatment (1)
- Speech signal processing (1)
- Splanchnic Hemodynamics (1)
- Staphylococcus aureus (1)
- Steatosis (1)
- Stem cell (1)
- Stem cells (1)
- Stenosis (1)
- Sterblichkeit (1)
- Steroid (1)
- Streptococcus pneumoniae (1)
- Stress (1)
- Stress and resilience (1)
- Striatum (1)
- Stromal cell (1)
- Structured reporting (1)
- Subarachnoid hemorrhage (1)
- Subcutaneous (1)
- Surface (1)
- Surgical education (1)
- Survival (1)
- Sustained virological response (SVR) (1)
- Systematic reviews (1)
- Systemic lupus erythematosus (1)
- Systems biology (1)
- Systems medicine (1)
- T cell (1)
- T cell receptors (1)
- TBK1 (1)
- TCR signaling cascade (1)
- TEER (1)
- TF-complexes (1)
- TGF-β1 (1)
- TILs (1)
- TIMP2 (1)
- TKI (1)
- TMEM126B (1)
- TMS (1)
- TMT (1)
- TP53-induced glycolysis and apoptosis regulator (1)
- TRIM25 (1)
- Tacrolimus (1)
- Target identification (1)
- Targeted therapies (1)
- Taxane (1)
- Tea (1)
- Telomere length (1)
- Telomeres (1)
- Texture analysis (1)
- Theft (1)
- Therapy (1)
- Therapy response (1)
- Thoracic trauma (1)
- Thromboembolism (1)
- Thrombosis (1)
- Thrombotic microangiopathy (1)
- Thrombotic thrombocytopenic purpura (1)
- Thromboxane (1)
- Thymocytes (1)
- Thymus (1)
- Tick (1)
- Time in therapeutic range (TTR) (1)
- Time to treatment failure (1)
- Tissue microarray (TMA) (1)
- Tools and ressources (1)
- Total hip replacement (1)
- Toxicity (1)
- Transcription Factors (1)
- Transcriptional control (1)
- Transgender (1)
- Translation initiation (1)
- Translational (1)
- Translational research (1)
- Trees (1)
- Treg cell (1)
- Trimeric autotransporter adhesins (1)
- Trk (1)
- TrkC (1)
- Trousseau’s syndrome (1)
- Trueness (1)
- Tularemia (1)
- Tumor heterogeneity (1)
- Tumour immunology (1)
- U-87MG (1)
- Ulcerative colitis (1)
- Ultrasonography (1)
- Ultrasound (1)
- Umbilical cord (1)
- Unilateral hip osteoarthritis (1)
- United States (1)
- Uveal melanoma (1)
- VARGADO (1)
- VDR (1)
- VEGFA (1)
- VGAT-ChR2 (1)
- VISTA (1)
- Vaccination (1)
- Vaccine breakthrough (1)
- Vacuoles (1)
- Validation (1)
- Vascular disease (1)
- Vasculogenesis (1)
- Veins (1)
- Video-oculography (1)
- Viral load (1)
- Virtual implant planning (1)
- Virtual patients (1)
- Virulence (1)
- Visual acuity (1)
- Visual impairments (1)
- Visual system (1)
- Vitamin K antagonists (1)
- Vitreous opacity (1)
- Vmem (1)
- Volume overload (1)
- Voriconazole (1)
- WNT (1)
- WT1 (1)
- Westphal-Paradigm (1)
- White blood cells (1)
- WoMo score (1)
- Working memory (1)
- Wound healing (1)
- Zebrafish (1)
- Zika virus (1)
- Zoonosis (1)
- abuse (1)
- accidents (1)
- acid sphingomyelinase (ASMase; Smpd1) (1)
- acneiform skin toxicity (1)
- acoustic radiation force impulse imaging (1)
- acute decompensation (1)
- acute liver failure (1)
- acute lung injury (1)
- acute lung injury (ALI) (1)
- acute-on-chronic liver failure (1)
- adalimumab (1)
- adeno-associated virus (1)
- adeno‐associated virus (1)
- adherence (1)
- adhesion (1)
- adipocytes (1)
- adiponectin (1)
- adipose tissue (1)
- adipose-derived mesenchymal stem cells (1)
- adipose-derived stem cells (1)
- adolescents (1)
- adoptive cancer immunotherapy (1)
- adrenal insuffciency (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- adverse effects (1)
- ageing (1)
- aging (1)
- air flow (1)
- air pollution (1)
- airborne bacteria (1)
- albumin (1)
- alcohol (1)
- alcohol dehydrogenase (ADH) (1)
- alcohol metabolism (1)
- alcoholic liver disease (1)
- alcoholic liver injury (1)
- alloHSCT (1)
- allogeneic stem cell transplantation (1)
- alpha receptor (1)
- alpha-synuclein (1)
- amisulpride (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anaemia (1)
- anal cancer (1)
- anaplastic large cell lymphoma (1)
- angio-immunogenic switch (1)
- animal models (1)
- anti-cancer therapy (1)
- antibodies (1)
- anticonvulsant (1)
- antiepileptic drug (1)
- antifibrotic therapy (1)
- antifungal therapy (1)
- antisynthetase antibodies (1)
- antisynthetase syndrome (1)
- antiviral drugs (1)
- apigenin (1)
- aromatics (1)
- arthritis (1)
- artificial intelligence (1)
- ascites (1)
- associative memory (1)
- astrocytoma (1)
- ataxia score (1)
- ataxia telangiectasia (1)
- atherosclerosis (1)
- atrial fibrillation (1)
- attention modulation (1)
- attention-deficit/hyperactivity disorder (1)
- attention-deficit/hyperactivitydisorder (1)
- attractiveness (1)
- augmentation (1)
- authentication (1)
- autism spectrum disorder (1)
- autologous stem cell transplantation (1)
- automated patch-clamp (1)
- azaindole (1)
- bacteria (1)
- basic mechanisms (1)
- basonuclin 2 (1)
- beam quality correction factors (1)
- belimumab (1)
- beta‐trace protein (1)
- bevacizumab (1)
- binary search procedure (1)
- bioacoustics (1)
- bioactivity (1)
- biofilm (1)
- biological treatments (1)
- biologics (1)
- biomarkers (1)
- biopsy (1)
- bipolar disorder (1)
- bladder cancer (1)
- bladder dose (1)
- blood flow restriction (1)
- bmal1 (1)
- body mass index (1)
- bone chips (1)
- bone damage (1)
- bone healing (1)
- bone loss (1)
- bone marrow derived mononuclear cells (1)
- bone morphogenetic proteins (BMPs) (1)
- bone regeneration (1)
- bone‐screw (1)
- bone–implant interface (1)
- borrelia (1)
- borrelia mayonii (1)
- brachytherapy (1)
- brain phosphorylome (1)
- brain states (1)
- bronchial allergen provocation (1)
- cadherin (1)
- calcitriol (1)
- callous-unemotional traits (1)
- calprotectin (1)
- calretinin (1)
- calretinin-knock out (1)
- cancer cell metabolism (1)
- cancer patients (1)
- cancer stem cells (1)
- cancer treatment (1)
- cancer-associated fibroblasts (1)
- cancer-specific survival (1)
- cannabis (1)
- cap-dependent translation (1)
- capsaicin (1)
- car indoor (1)
- carbapenemases (1)
- carbon oxides (COx) (1)
- cardiac myocytes (1)
- cardiomegaly (1)
- cardiovascular (1)
- cardiovascular management (1)
- case reports (1)
- caspase 8 (1)
- caspase-8 (1)
- catheter removal (1)
- cdk (1)
- cell adhesion (1)
- cell biology (1)
- cell cycle arrest (1)
- cell cycling (1)
- cell death (1)
- cell growth (1)
- cell line (1)
- cell motility (1)
- cell survival mechanisms (1)
- cell therapy (1)
- centrifugation (1)
- ceramide (1)
- ceramide synthase (CERS2/CERS1) (1)
- cerebral radiation necrosis (1)
- cerebrovascular disease (1)
- ceritinib (1)
- cervical cancer (1)
- channelrhodopsin (1)
- characterization (1)
- checkpoint proteins (1)
- chemokine receptors (1)
- chemoradiotherapy (1)
- chemoresistance (1)
- chemotherapy (1)
- chemotherapy resistance (1)
- chest injury (1)
- chest trauma (1)
- child (1)
- childhood abuse (1)
- children (1)
- chimeric antigen receptor (1)
- chronic myeloid leukemia (1)
- chronobiology (1)
- cigarette strength (1)
- cigarettes (1)
- circadian rhythm (1)
- circulating miRNA (1)
- classical conditioning (1)
- classification of bone defects (1)
- clinical immunology (1)
- clinical research (1)
- clinical study (1)
- clinical trial (1)
- cloacae (1)
- clock genes (1)
- clonal dominance (1)
- clonal hematopoiesis (1)
- cochlear implant (1)
- cognitive deficits (1)
- cognitive functions (1)
- collagen (1)
- collagen I (1)
- collagen degradation marker (1)
- collateral sprouting (1)
- colon carcinoma cells (1)
- colorectal carcinoma (1)
- combination treatment (1)
- common variant (1)
- complex I (1)
- complex I deficiency (1)
- compliance (1)
- computational models (1)
- computational neuroscience (1)
- computational techniques (1)
- computational virology (1)
- concordance (1)
- conduct disorder (1)
- connective tissue graft (1)
- consensus paper (1)
- convolution neural network (1)
- coordination (1)
- copeptin (1)
- cornea donor (1)
- coronary artery bypass graft surgery (1)
- cortical malformation (1)
- cortical thickness (1)
- cortisol (1)
- cost-effective (1)
- courting behavior (1)
- critical size defect (1)
- critically ill patients (1)
- cross-sectional study (1)
- cryopreservation (1)
- cyclin D1 (1)
- cyclins (1)
- cyclosporine (1)
- cystatin C (1)
- cystic fibrosis (1)
- cytochrome P450 2E1 (1)
- cytokine, angiogenesis (1)
- cytotoxic T cells (1)
- death (1)
- death receptor (1)
- deep neural network (1)
- defect configuration (1)
- delayed wound healing (1)
- dental implants (1)
- depression (1)
- depressive symptoms (1)
- desmoplastic small round cell tumor (1)
- detoxification (1)
- diabetic neuropathy (1)
- diffusion tensor imaging (1)
- diffusion tensor imaging (DTI) (1)
- dimethylfumarate (1)
- direct-acting antivirals (DAAs) (1)
- directed disulfide bond formation (1)
- discoidin domain-containing receptor (1)
- discomfort/pain (1)
- disease-free survival (1)
- dissemination (1)
- distal pronephric outlet obstruction (1)
- distress (1)
- docetaxel (1)
- dopamine (1)
- dosimetry (1)
- double inversion recovery (DIR) (1)
- doxorubicin (1)
- drilling tool design (1)
- drug induced liver injury (1)
- drug metabolism and distribution (1)
- drug release (1)
- drug resistance (1)
- drug targets (1)
- drug therapy (1)
- drug-induced liver injury (1)
- drug-induced liver injury (DILI) (1)
- dual task (1)
- dynamic 18F-FDG PET/CT (1)
- early continence (1)
- early loss (1)
- early tumor stages (1)
- economy (1)
- edema (1)
- ejection fraction (EF) (1)
- elderly patients (1)
- electrical stimulation (1)
- electrocardiography (1)
- electron transport chain (1)
- eltrombopag (1)
- emergency care (1)
- emergent self-organizing maps (1)
- emotional information processing (1)
- empowerment (1)
- endometriosis (1)
- endophytes (1)
- endoplasmic reticulum (1)
- endothelial cell (1)
- endothelial cells (1)
- endothelial to mesenchymal transition (1)
- endotoxins (1)
- entorhinal cortex lesion (1)
- envelope technique (1)
- eosinophil cationic protein (1)
- eosinophils (1)
- epigenetic (1)
- epigenetics (1)
- epigenome (1)
- euthymic (1)
- evaluation (1)
- evaluation practice (1)
- everolimus (1)
- evoked response (1)
- evolution (1)
- ex vivo expansion (1)
- excess fluid volume (1)
- executive function (1)
- exercise training (1)
- exosomes (1)
- expression studies (1)
- extracellular vesicles (1)
- eye tracking (1)
- face-name association task (1)
- factor H (1)
- factor IX (1)
- factor VIII (1)
- fat (1)
- fatty acid elongase (Elovl1/4/5) (1)
- fatty acids (1)
- feedback (1)
- femoral artery ligation (1)
- fibroblasts (1)
- fibrocytes (1)
- fibrosis (1)
- fibrotest (1)
- fidaxomicin (1)
- fitness (1)
- fixed partial dentures (1)
- fizička aktivnost; (1)
- flavivirus entry factor (1)
- flow cytometry (1)
- fluorescent dye (1)
- focal adhesion (1)
- focal cortical dysplasia (FCD) (1)
- fresh frozen plasma (1)
- full-contour crown restorations (1)
- functional connectivity (1)
- functional genetics (1)
- fungal pathogens (1)
- fungi (1)
- fusion (1)
- gRNA library (1)
- gadolinium‐based contrast agent (1)
- gel spacer injection (1)
- gender (1)
- gender dysphoria (1)
- gender-affirming hormone therapy (1)
- gene expression (1)
- gene expression analysis (1)
- gene regulation (1)
- gene signature (1)
- gene therapy (1)
- genetics (1)
- genetics and genomics (1)
- gene×environment interactions (1)
- genome-wide (1)
- glecaprevir (1)
- glial activation (1)
- glioblastoma (GBM) (1)
- global diversity (1)
- glutamate (1)
- glutamine (1)
- gossypol (1)
- graft-versus host (1)
- granulocytecolony stimulating factor (1)
- granuloma (1)
- gray‐white matter blurring (1)
- growth (1)
- growth hormone (1)
- growth inhibition (1)
- gut microbiota (1)
- haemophilia (1)
- head and neck cancer (1)
- head-to-head (1)
- health apps (1)
- health‐related quality of life (1)
- heart (1)
- heart rate (1)
- heat (1)
- hematopoiesis (1)
- hematopoietic stem cell mobilization (1)
- hematopoietic stem cells (1)
- hematopoietic stress (1)
- hepatic osteodystrophy (1)
- hepatic phenotype (1)
- hepatic steatosis (1)
- hepatitis B (1)
- hepatitis B virus (1)
- hepatitis C virus (HCV) (1)
- herb induced liver injury (1)
- hereditary angioedema (1)
- high molecular weight plasticizer (1)
- high-dimensional data sets (1)
- high-dose-rate interstitial brachytherapy (1)
- high-energy photon and proton radiation (1)
- hippocampus (1)
- histone deacetylases (HDACs) (1)
- hospital exemption (1)
- host cell interaction (1)
- host cell response (1)
- host immune response (1)
- host-directed therapies (1)
- hostpathogen interaction (1)
- human Natural Killer cell (1)
- human antigen R (HuR) (1)
- human biology and medicine (1)
- human cytomegalovirus (1)
- human immunodeficiency virus (1)
- human skin graft (1)
- humectant agents (1)
- hygienic hand disinfection (1)
- hygienische Händedesinfektion (1)
- hypertension and anti-hypertensive treatment (1)
- hypoparathyroidism (1)
- hypoxia-inducible factor (1)
- idiopathic dystonia (1)
- idiopathic pulmonary fibrosis (1)
- idiosyncratic DILI (1)
- ifenprodil (1)
- illness experiences (1)
- image analysis (1)
- immune deficiency (1)
- immune dysregulation (1)
- immune landscape (1)
- immune responses (1)
- immune system (1)
- immune-checkpoint inhibition (1)
- immunity (1)
- immunoglobulin superfamily (1)
- immunological research (1)
- immunology and infectious diseases (1)
- immunosuppressive agent (1)
- immunosuppressive drug (1)
- implant movement (1)
- implant stability (1)
- in silico simulation (1)
- in vivo micro‐CT (1)
- indication (1)
- indomethacin (1)
- induced membrane (1)
- infiltration (1)
- inflammatory bowel disease (1)
- information transfer (1)
- inhibitory interneurons (1)
- insect herbivory (1)
- insertion (1)
- insula (1)
- integrated stress response (1)
- intensive care unit (1)
- interferon gamma (1)
- internal ribosomal entry site (IRES) (1)
- interstitial lung disease (1)
- intestinal barrier (1)
- intrinsic DILI (1)
- intrinsic apoptosis (1)
- invasive fungal disease (1)
- ionotropic glutamate receptors (1)
- iron chelation (1)
- iron chelator (1)
- iron chelators (1)
- iron deficiency (1)
- iron homeostasis (1)
- iron metabolism (1)
- irradiation (1)
- isogenic (1)
- ixekizumab (1)
- junctional adhesion molecule (1)
- juvenile myoclonic epilepsy (1)
- kidney transplantation (1)
- kinesin (1)
- lapatinib (1)
- latent tuberculosis infection (1)
- left ventricular function (1)
- legal gender reassignment (1)
- leukocytes (1)
- leukodystrophy (1)
- lifelong learning (1)
- light transmission aggregometry (1)
- liminality (1)
- linoleic acid metabolites (1)
- lipid mediator (1)
- lipid metabolism (1)
- lipids (1)
- lipids inflammatory pain (1)
- lipocalin-2 (1)
- lipopolyplex (1)
- lipopolysaccharide (1)
- lipoxygenase (1)
- liquid-PRF (1)
- liver (1)
- liver adaption (1)
- liver cancer (1)
- liver cell lines (1)
- liver diseases (1)
- liver fibrosis (1)
- liver injury (1)
- liver metabolism (1)
- local control (1)
- long-term distress (1)
- longitudinal relaxation time T1 (1)
- low speed centrifugation concept (1)
- low-back pain (1)
- low-cost medication (1)
- lower urinary tract obstruction (1)
- luteolin (1)
- lyme disease (1)
- lymphangiogenesis (1)
- mGluR3 (1)
- mGluR5 (1)
- mRNA active cancer immunotherapy (1)
- mRNA decay (1)
- mRNA stability (1)
- mTOR inhibition (1)
- mTORC1 (1)
- machine learning (1)
- machine-learning (1)
- maintenance therapy (1)
- major adverse cardiac events (1)
- major depressive disorder (1)
- malignant glioma (1)
- mammary cancer (1)
- mammary carcinoma (1)
- marathon (1)
- maraton (1)
- mass spectrometry (1)
- massive weight loss (1)
- massively parallel multigrid solvers (1)
- mathematical models of viral RNA cycle (1)
- matrix metalloproteinase (1)
- mechanistic target of rapamycin (mTOR) (1)
- medial thigh lift (1)
- medical error (1)
- medulloblastoma resection (1)
- memantine (1)
- memory (1)
- meningioma (1)
- merkel cell carcinoma (1)
- mesenchymal stromal cell (1)
- mesenchymal stromal/stem cells (1)
- metabolites (1)
- metastasis (1)
- metastates (1)
- metformin (1)
- methylation profiling (1)
- miR (1)
- miR-143-3p (1)
- miR-181 (1)
- miR-375 (1)
- mice (1)
- microbiome (1)
- microdosing (1)
- microglia (1)
- microsomal ethanol-oxidizing system (MEOS) (1)
- microtubular cytoskeleton (1)
- microtubule disruptors (1)
- mild cognitive impairment (1)
- mitochondrial bioenergetics and glycolysis (1)
- mitochondrial disease (1)
- mitophagy (1)
- mobile phone apps (1)
- mobile tongue cancer (1)
- modeling (1)
- molecular diagnosis (1)
- molecular marker (1)
- montelukast (1)
- motility (1)
- mouse (1)
- mouse model (1)
- movement disorders (1)
- mpMRI (1)
- mtor (1)
- mucosal inflammation (1)
- mucositis (1)
- multidisciplinary pain treatment (1)
- multimorbidity (1)
- multiplex immunofluorescence (1)
- musician (1)
- mutations (1)
- mycophenolate mofetil [MMF] (1)
- myeloid cells (1)
- myocardial infarction (1)
- myocardial injury (1)
- myocardium (1)
- myogenic tone (1)
- myogenic vasoconstriction (1)
- myositis (1)
- nadp (1)
- nanoparticles (1)
- natural killer cells (1)
- nematophin (1)
- neoplasms (1)
- nerve-sparing (1)
- network analysis (1)
- network neuroscience (1)
- neural network (1)
- neuroblastoma (1)
- neurodegeneration (1)
- neurodevelopmental disorders (1)
- neuronal silencing (1)
- neurons (1)
- neuropathic pain (1)
- neuropsychological impairment (1)
- neurotrophins (1)
- neutral ceramidase (Asah2) (1)
- neutral sphingomyelinase (Smpd3) (1)
- new miRNA functions (1)
- nintedanib (1)
- nitrogen oxides (NOx) (1)
- nocardia (1)
- nocardiosis (1)
- nodular sclerosis (1)
- non-classical adhesion molecule (1)
- non-invasive fibrosis assessment (1)
- non-sensory bias (1)
- non-small-cell lung cancer (1)
- noradrenaline (1)
- norepinephrine (1)
- nutrient deprivation (1)
- observational cohort study (1)
- oksidacioni stres (1)
- older patients (1)
- olivo-ponto-cerebellar atrophy (OPCA) (1)
- oncogene (1)
- oncolytic virotherapy (1)
- optogenetics (1)
- organ dysfunction (1)
- organ failure (1)
- organisation of health services (1)
- organophosphate flame retardants (OFR) (1)
- orthodontic mini‐implant (1)
- oscillator (1)
- osteoarthritis (1)
- osteogenesis (1)
- osteopenia (1)
- osteotomy (1)
- outcome (1)
- overall survival (1)
- overweight (1)
- oxidative stress (1)
- p14 (1)
- p62 (1)
- p75 (1)
- pack-years (PY) (1)
- pain (1)
- pain management (1)
- pain target (1)
- palatal tremor (1)
- particulate matter (PM) (1)
- passive reading paradigm (1)
- patent (1)
- patient (1)
- patient and public involvement (1)
- patient blood management (1)
- patient perspective (1)
- patient preference (1)
- patient safety (1)
- patients' experience (1)
- patient‐centred outcomes (1)
- pazopanib (1)
- pediatric patients (1)
- pedicle screws (1)
- peficitinib (1)
- perforant path transection (1)
- performance evaluation (1)
- performance-based funding allocation (1)
- perio-prosthetic joint infection (1)
- periodontal probing, (1)
- periodontitis (1)
- perirenal (1)
- peri‐implant lesions (1)
- peri‐implant probing (1)
- peri‐implantitis (1)
- pharmaco-fMRI (1)
- pharmacodynamics (1)
- pharmacogenetics (1)
- pharmacoresistance (1)
- phase 3 study (1)
- phosphatases (1)
- phylogenetic analysis (1)
- physical activity (1)
- pibrentasvir (1)
- pitch perception (1)
- placement (1)
- plant growth (1)
- plant resistance (1)
- plant-insect interactions (1)
- plasmid (1)
- plastic (1)
- plasticity (1)
- platelet aggregation (1)
- platelet lysate (1)
- platelet rich plasma (1)
- platelet-rich fibrin (1)
- platelets (1)
- platform switching (1)
- pleuropericarditis (1)
- point shear wave elastography (1)
- polo-like kinase 1 (1)
- polo-like kinase 3 (1)
- poly(lactic-co-glycolic acid) (PLGA) (1)
- polyethylenimine (1)
- polyomavirus (MCPyV) (1)
- polypharmacology (1)
- population dynamics (1)
- post-translational modifications (PTMs) (1)
- posterior fossa masses (1)
- postmortem blood samples (1)
- posttraumatic stress disorder (1)
- post‐traumatic stress disorder (1)
- power dynamics (1)
- pranlukast (1)
- pre-clinical models (1)
- preeclampsia (1)
- prefrontal cortex (1)
- preoperative anaemia management (1)
- pressure cycling technology (1)
- pressure ulcer treatment (1)
- preterm birth (1)
- primary cilium (1)
- primary immunodeficiency (1)
- primary immunodeficiency (PID) (1)
- progestin (1)
- prognosis (1)
- progressive myoclonus epilepsy (1)
- pronephric development (1)
- prophylaxis (1)
- prospective studies (1)
- protein tagging (1)
- proto-oncogene proteins c-akt (1)
- proton density (1)
- proton pump inhibitors (1)
- psoriatic arthritis (1)
- psychological distress (1)
- psychophysiology (1)
- psychosocial stress (1)
- public health (1)
- pulmonary nocardiosis (1)
- pulse labeling (1)
- pulse-spreading harmonic complex (1)
- pupil dilation (1)
- pupillary reactivity (1)
- qualitative research (1)
- quality assurance (1)
- quantitative T1 mapping (1)
- quantitative T1‐difference maps (1)
- radiation therapy (1)
- radioimmunotherpay (1)
- radioresponse (1)
- radixin (1)
- randomized (1)
- rare variant (1)
- re-emerging virus (1)
- re-osseointegration (1)
- reactivation (1)
- reactive oxygen species (ROS) (1)
- reaktivne vrste kiseonika (1)
- real-world data (1)
- realistic geometries (1)
- recertification (1)
- recommendations (1)
- recurrent laryngeal nerve palsy (1)
- refractory aGvHD (1)
- regeneration (1)
- registry for primary immunodeficiency (1)
- regorafenib (1)
- regorafenib csf concentration (1)
- relaxometry (1)
- remote monitoring (1)
- removal (1)
- renal cell cancer (1)
- renin-angiotensin system (1)
- reorganization (1)
- repeat DMEK (1)
- reservoir computing (1)
- resistance (1)
- resistance-associated substitutions (RAS) (1)
- resting-state fMRI (1)
- resting‐state (1)
- retrospective (1)
- revalidation (1)
- revision surgery (1)
- rhabdomyosarcoma (1)
- rhabdomyosarcomas (1)
- rheumatoid arthritis (1)
- ribavirin (1)
- right ventricular function (1)
- risk factor progression (1)
- risk genes (1)
- risk management (1)
- root coverage (1)
- rosetting T cells (1)
- rub-in technique (1)
- running wheel (1)
- sRNA (1)
- sRNA tool (1)
- safety (1)
- scaffold size (1)
- schizophrenia (1)
- schizophrenia spectrum (1)
- sclerostin (1)
- scoping review (1)
- screening test (1)
- screw augmentation (1)
- screw loosening (1)
- second-hand smoke (1)
- secretion (1)
- seed germination (1)
- segmentation (1)
- seizure (1)
- selectin (1)
- sensorimotor exercise training (1)
- sensory neuropathy (1)
- sensory processing (1)
- serine palmitoyltransferase 2 (Sptlc2) (1)
- serologic screening (1)
- serositis (1)
- serum albumin deficiency (1)
- severe vitamin D deficiency (1)
- sex differences (1)
- sexually transmitted diseases (1)
- sexually transmitted infection (1)
- sham (1)
- shortening of treatment (1)
- shunt (1)
- siRNA analysis (1)
- siRNA delivery (1)
- siRNA quantification (1)
- siRNA/RNAi (1)
- signature (1)
- silicone device (1)
- simulation (1)
- simulation training (1)
- single-sided deafness (1)
- sinus rhythm (1)
- six-step technique (1)
- smoking (1)
- sofosbuvir (1)
- soft tissue sarcoma (1)
- soft tissue sarcoma (STS) (1)
- soluble epoxide hydrolase (1)
- somatic mutations (1)
- sonic hedgehog signaling (1)
- sound-induced flash illusion (1)
- spatial specificity (1)
- spectroscopy (1)
- sphingolipid (1)
- spider toxin (1)
- spiking neural networks (1)
- spinal fusion (1)
- spirochete (1)
- spirochetes (1)
- starvation (1)
- stem cell transplantation (1)
- steroid-resistant aGvHD (1)
- stimulation (1)
- stopping rule (1)
- stratification (1)
- strength training (1)
- stress response (1)
- stroke (1)
- structural covariance (1)
- subcutaneous fat (1)
- subjunctivity (1)
- success rate (1)
- sulfasalazine (1)
- suplementacija (1)
- supplementation (1)
- support vector machines (1)
- surveillance (1)
- survival (1)
- survival rate (1)
- synaptic signaling (1)
- synovial fibroblast (1)
- systemic inflammation (1)
- t-distributed stochastic neighbor embedding (1)
- tDCS (1)
- tacrolimus (1)
- target variability (1)
- telemedicine (1)
- telmisartan (1)
- temozolomide (1)
- temsirolimus (1)
- temsirolimus-resistance (1)
- thighplasty (1)
- thrombocyte dysfunction (1)
- thrombocyte function (1)
- thrombolysis (tPA) (1)
- thrombopietin receptor agonist (1)
- thrombospondin-4 (1)
- thymus (1)
- thyroid resection (1)
- tissue Doppler imaging (1)
- tissue engineering (1)
- tolerance (1)
- tongue edema (1)
- topographic maps (1)
- total joint arthroplasty (TJA) (1)
- trafficking (1)
- transcriptional profiling (1)
- transcriptome (1)
- transdifferentiation (1)
- transforming growth factor beta (1)
- transforming growth factor beta (TGF-β) (1)
- transient elastography (1)
- transient receptor potential channels (1)
- translation (1)
- transmission and vector control (1)
- transsexualism (1)
- trastuzumab (1)
- trophoblastic cell lines (1)
- trophoblasts (1)
- troponin (1)
- tumor (1)
- tumor growth (1)
- tumor immune evasion (1)
- tumor microenviroment (1)
- tumor progression (1)
- tumor proliferation (1)
- tumor‐associated macrophages (1)
- two-tissue compartment model (1)
- tyrosine kinase inhibitor (1)
- ulcerative colitis (1)
- uncertainty (1)
- unfolded protein response (1)
- ustekinumab (1)
- uterine cervical cancer (1)
- vaccine (1)
- valproic acid (1)
- vancomycin (1)
- vascular complications (1)
- vascular disease (1)
- vascular dysfunction and inflammation (1)
- vascular smooth muscle (1)
- velpatasvir (1)
- ventral tegmental area (1)
- vesicovaginal septum (1)
- viability (1)
- viral dynamics (1)
- viral gene transfer (1)
- virulence (1)
- vitamin D supplementation (1)
- vitamin D target genes (1)
- vitamin Dmetabolism (1)
- voice (1)
- volatile organic compounds (VOC) (1)
- voluntary training (1)
- voxilaprevir (1)
- within-host viral modeling (1)
- women (1)
- words (1)
- work-life balance (1)
- working conditions (1)
- wound healing (1)
- yellow fever virus (1)
- yellow fever virus tropism (1)
- zafirlukast (1)
- zebrafish (1)
- zirconia (1)
- Überwachung (1)
- β-catenin (1)
- β-lactamases (1)
- γδT cell (1)
- гепатит С (1)
- правила прекращения лечения (1)
- противовирусные препараты прямого действия (ПППД) (1)
- сокращение лечения (1)
- устойчивый вирусологический ответ (УВО) (1)
- flow cytometry (1)
Institute
- Medizin (500) (remove)
We investigate system-size effects on the rotational diffusion of membrane proteins and other membrane-embedded molecules in molecular dynamics simulations. We find that the rotational diffusion coefficient slows down relative to the infinite-system value by a factor of one minus the ratio of protein and box areas. This correction factor follows from the hydrodynamics of rotational flows under periodic boundary conditions and is rationalized in terms of Taylor-Couette flow. For membrane proteins like transporters, channels, or receptors in typical simulation setups, the protein-covered area tends to be relatively large, requiring a significant finite-size correction. Molecular dynamics simulations of the protein adenine nucleotide translocase (ANT1) and of a carbon nanotube porin in lipid membranes show that the hydrodynamic finite-size correction for rotational diffusion is accurate in standard-use cases. The dependence of the rotational diffusion on box size can be used to determine the membrane viscosity.
Acne‐like skin reactions frequently occur in patients undergoing treatment with drugs inhibiting the epidermal growth factor receptor. Recently, the effects of vitamin K1 containing cream (Reconval K1) as prophylactic skin treatment in addition to doxycycline were explored in a double‐blind randomized phase II trial (EVITA) in patients with metastatic colorectal cancer receiving cetuximab. EVITA demonstrated a trend towards less severe skin rash in Reconval K1‐treated patients using the tripartite WoMo skin reaction grading score as a thorough tool for quantification of drug related skin reactions. This gender‐specific analysis of the EVITA trial evaluated the application of the WoMo score for assessment of epidermal growth factor receptor (EGFR)‐related skin toxicities according to treatment arm and gender. To show the robustness of results parametric and non‐parametric statistical analyses were conducted. All three parts of the WoMo score independently demonstrated the superiority of the treatment arm (Reconval K1) regarding a significant reduction in acneiform skin reactions in women. Men did not benefit from Reconval K1 cream at any time point in none of the WoMo score analyses. The treatment effect in women was confirmed by the use of skin rash categories based on the final WoMo overall score and mixed effect longitudinal multiple linear regression analysis. The WoMo score represents a sensitive tool for studies exploiting treatments against EGFR mediated acne‐like skin rash. Part C of the WoMo score seems to be sufficient for quantification of drug related skin toxicities in further studies. Standard WoMo skin reaction score values for future studies are provided.
Background: Pancreatic surgery demands complex multidisciplinary management. Clinical pathways (CPs) are a tool to facilitate this task, but evidence for their utility in pancreatic surgery is scarce. This study evaluated the effect of CPs on quality of care for pancreatoduodenectomy.
Methods: Data of all consecutive patients who underwent pancreatoduodenectomy before (n = 147) or after (n = 148) CP introduction were evaluated regarding catheter and drain management, postoperative mobilization, pancreatic enzyme substitution, resumption of diet and length of stay. Outcome quality was assessed using glycaemia management, morbidity, mortality, reoperation and readmission rates.
Results: Catheters and abdominal drainages were removed significantly earlier in patients treated with CP (p < 0.0001). First intake of liquids, nutritional supplement and solids was significantly earlier in the CP group (p < 0.0001). Exocrine insufficiency was significantly less common after CP implementation (47.3% vs. 69.7%, p < 0.0001). The number of patients receiving intraoperative transfusion dropped significantly after CP implementation (p = 0.0005) and transfusion rate was more frequent in the pre-CP group (p = 0.05). The median number of days with maximum pain level >3 was significantly higher in the CP group (p < 0.0001). There was no significant difference in mortality, morbidity, reoperation and readmission rates.
Conclusions: Following implementation of a CP for pancreatoduodenectomy, several indicators of process and outcome quality improved, while others such as mortality and reoperation rates remained unchanged. CPs are a promising tool to improve quality of care in pancreatic surgery.
Background: With the current study, we aimed to determine the prevalence of back pain in employees of a German chemical company. We put a specific focus on disabling back pain and its association with sociodemographic, lifestyle- and work-related characteristics.
Methods: We used cross-sectional data, surveyed in health check-ups between 2011 and 2014 in Ludwigshafen am Rhein (Germany). A blood sample, physical examination and anamnesis by an occupational health physician as well as a written questionnaire were part of the check-up. A modified version of the Standardised Nordic Musculoskeletal Questionnaire was utilized to survey the back-pain specific information. Disabling back pain was defined as presence of any back pain in the past 12 months which prevented employees from carrying out their usual working tasks. We used multinomial logistic regression analysis to assess the association between (categorical) duration of disabling back pain and sociodemographic, lifestyle-, and work-related characteristics.
Results: Overall, 17,351 employees participated in the health check-up, information on 16,792 persons could be used for analyses. Participants were on average 43.7 (SD: 9.7) years old and mainly male (79.1%). Lifetime-, 12-months-, and 7-days-prevalence of any type and duration of back pain were 72.5, 66.1, and 27.1% respectively. About one third (33.5%) had suffered from an episode of disabling back pain, 16.7% 1–7 days, 10.3% 8–30 days, and 6.5% more than 30 days. Multinomial regression analysis yielded that 8–30 days or more than 30 days of disabling back pain (relative to 0 days) were more likely with older age, female gender, being married, former or current smoking, lower occupational status, higher work-related stress score, history of a spinal injury, and diagnosed dorsopathy.
Conclusions: There is a great need for action regarding multifaceted preventive measures and early interventions, especially for manual workers, older employees and women, where occupational medicine can play a decisive role.
Background: Serial volumetric changes of reconstructed breasts have not been studied in detail. In this study, we analyzed serial volumetric changes of reconstructed and contralateral normal breasts during long-term follow-up, with a focus on the effect of various adjuvant therapies.
Methods: Among all patients who underwent immediate breast reconstruction with a unilateral pedicled transverse rectus abdominis musculocutaneous (p-TRAM) flap, 42 patients with valid data from ≥3 postoperative positron emission tomography-computed tomography (PET-CT) scans were included. The volumes of the reconstructed and normal breasts were measured, and the ratio of flap volume to that of the contralateral breast was calculated. Serial changes in volume and the volume ratio were described, and the effects of chemotherapy, radiation therapy, and hormone therapy on volumetric changes were analyzed.
Results: The mean interval between the initial reconstruction and each PET-CT scan was 16.5, 30, and 51 months respectively. Thirty-five, 36, and 10 patients received chemotherapy, hormone therapy, and radiation therapy, respectively. The flap volume at each measurement was 531.0, 539.6, and 538.0 cm3, and the contralateral breast volume was 472.8, 486.4, and 500.8 cm3, respectively. The volume ratio decreased from 115.1% to 113.4%, and finally to 109.6% (P=0.02). Adjuvant therapies showed no significant effects.
Conclusions: We demonstrated that the p-TRAM flap maintained its volume over a long-term follow up, while the volume of the contralateral native breast slowly increased. Moreover, adjuvant breast cancer therapies had no statistically significant effects on the volume of the reconstructed p-TRAM flaps or the contralateral native breasts.
Mastectomy in female-to-male transgender patients: A single-center 24-year retrospective analysis
(2019)
Background: Mastectomy in male transgender patients is an important (and often the first) step toward physical manhood. At our department, mastectomies in transgender patients have been performed for several decades.
Methods: Recorded data were collected and analyzed for all male transgender patients undergoing mastectomy over a period of 24 years at our department.
Results: In total, 268 gender-reassigning mastectomies were performed. Several different mastectomy techniques (areolar incision, n=172; sub-mammary incision, n=96) were used according to patients’ habitus and breast features. Corresponding to algorithms presented in the current literature, certain breast qualities were matched with a particular mastectomy technique. Overall, small breasts with marginal ptosis and good skin elasticity allowed small areolar incisions as a method of access for glandular removal. In contrast, large breasts and those with heavy ptosis or poor skin elasticity often required larger incisions for breast amputation. The secondary correction rate (38%) was high for gender reassignment mastectomy, as is also reflected by data in the current literature. Secondary correction frequently involved revision of chest wall recontouring, suggesting inadequate removal of the mammary tissue, as well as scar revision, which may reflect intense traction during wound healing (36%). Secondary corrections were performed more often after using small areolar incision techniques (48%) than after using large sub-mammary incisions (21%).
Conclusions: Choosing the suitable mastectomy technique for each patient requires careful individual evaluation of breast features such as size, degree of ptosis, and skin elasticity in order to maximize patient satisfaction and minimize secondary revisions.
Objective: We sought to evaluate the efficacy and tolerability of intranasal midazolam (in‐MDZ) as first‐line inhospital therapy in patients with status epilepticus (SE) during continuous EEG recording.
Methods: Data on medical history, etiology and semiology of SE, anticonvulsive medication usage, efficacy and safety of in‐MDZ were retrospectively reviewed between 2015 and 2018. Time to end of SE regarding the administration of in‐MDZ and ß‐band effects were analyzed on EEG and with frequency analysis.
Results: In total, 42 patients (mean age: 52.7 ± 22.7 years; 23 females) were treated with a median dose of 5 mg of in‐MDZ (range: 2.5–15 mg, mean: 6.4 mg, SD: 2.6) for SE. The majority of the patients suffered from nonconvulsive SE (n = 24; 55.8%). In total, 24 (57.1%) patients were responders, as SE stopped following the administration of in‐MDZ without any other drugs being given. On average, SE ceased on EEG at 05:05 (minutes:seconds) after the application of in‐MDZ (median: 04:56; range: 00:29–14:53; SD:03:13). Frequency analysis showed an increased ß‐band on EEG after the application of in‐MDZ at 04:07 on average (median: 03:50; range: 02:20–05:40; SD: 01:09). Adverse events were recorded in six patients (14.3%), with nasal irritations present in five (11.9%) and prolonged sedation occurring in one (2.6%) patient.
Conclusions: This pharmaco‐EEG–based study showed that in‐MDZ is effective and well‐tolerated for the acute treatment of SE. EEG and clinical effects of in‐MDZ administration occurred within 04:07 and 5:05 on average. Intranasal midazolam appears to be an easily applicable and rapidly effective alternative to buccal or intramuscular application as first‐line treatment if an intravenous route is not available.
The goal of this study was to identify a novel target for antibody-drug conjugate (ADC) development in triple negative breast cancer (TNBC), which has limited treatment options, using gene expression datasets and in vitro siRNA/CRISPR and in vivo functional assays. We analyzed 4467 breast cancers and identified GABRP as top expressed gene in TNBC with low expression in most normal tissues. GABRP protein was localized to cell membrane with broad range of receptors/cell (815–53,714) and expressed by nearly half of breast cancers tissues. GABRP gene knockdown inhibited TNBC cell growth and colony formation in vitro and growth of MDA-MB-468 xenografts in nude mice. Commercially available anti-GABRP antibody (5–100 μg/ml) or de novo generated Fabs (20 μg/ml) inhibited TNBC cell growth in vitro. The same antibody conjugated to mertansine (DM1) also showed significant anticancer activity at nanomolar concentrations. Our results indicate that GABRP is a potential novel therapeutic target for ADC development.
Objectives: There is sparse information on the safety of early primary discharge from the emergency department (ED) after rule-out of myocardial infarction in suspected acute coronary syndrome (ACS). This prospective registry aimed to confirm randomised study results in patients at low-to-intermediate risk, with a broader spectrum of symptoms, across different institutional standards and with a range of local troponin assays including high-sensitivity cTn (hs-cTn), cardiac troponin (cTn) and point-of-care troponin (POC Tn).
Design: Prospective, multicentre European registry.
Setting: 18 emergency departments in nine European countries (Germany, Austria, Switzerland, France, Spain, UK, Turkey, Lithuania and Hungary)
Participants: The final study cohort consisted of 2294 patients (57.2% males, median age 57 years) with suspected ACS.
Interventions: Using the new dual markers strategy, 1477 patients were eligible for direct discharge, which was realised in 974 (42.5%) of patients.
Main outcome measures: The primary endpoint was all-cause mortality at 30 days.
Results: Compared with conventional workup after dual marker measurement, the median length of ED stay was 60 min shorter (228 min, 95% CI: 219 to 239 min vs 288 min, 95% CI: 279 to 300 min) in the primary dual marker strategy (DMS) discharge group. All-cause mortality was 0.1% (95% CI: 0% to 0.6%) in the primary DMS discharge group versus 1.1% (95% CI: 0.6% to 1.8%) in the conventional workup group after dual marker measurement. Conventional workup instead of discharge despite negative DMS biomarkers was observed in 503 patients (21.9%) and associated with higher prevalence of ACS (17.1% vs 0.9%, p<0.001), cardiac diagnoses (55.2% vs 23.5%, p<0.001) and risk factors (p<0.01), but with a similar all-cause mortality of 0.2% (95% CI: 0% to 1.1%) versus primary DMS discharge (p=0.64).
Conclusions: Copeptin on top of cardiac troponin supports safe discharge in patients with chest pain or other symptoms suggestive of ACS under routine conditions with the use of a broad spectrum of local standard POC, conventional and high-sensitivity troponin assays.
Trial registration number NCT02490969.
Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both.
Methods: We used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents).
Results: Behaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity.
Conclusions: Our results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.
Protease inhibitors (PIs) are important components of treatment regimens for patients with chronic hepatitis C virus (HCV) infection. However, emergence and persistence of antiviral resistance could reduce their efficacy. Thus, defining resistance determinants is highly relevant for efforts to control HCV. Here, we investigated patterns of PI resistance–associated substitutions (RASs) for the major HCV genotypes and viral determinants for persistence of key RASs. We identified protease position 156 as a RAS hotspot for genotype 1‐4, but not 5 and 6, escape variants by resistance profiling using PIs grazoprevir and paritaprevir in infectious cell culture systems. However, except for genotype 3, engineered 156‐RASs were not maintained. For genotypes 1 and 2, persistence of 156‐RASs depended on genome‐wide substitution networks, co‐selected under continued PI treatment and identified by next‐generation sequencing with substitution linkage and haplotype reconstruction. Persistence of A156T for genotype 1 relied on compensatory substitutions increasing replication and assembly. For genotype 2, initial selection of A156V facilitated transition to 156L, persisting without compensatory substitutions. The developed genotype 1, 2, and 3 variants with persistent 156‐RASs had exceptionally high fitness and resistance to grazoprevir, paritaprevir, glecaprevir, and voxilaprevir. A156T dominated in genotype 1 glecaprevir and voxilaprevir escape variants, and pre‐existing A156T facilitated genotype 1 escape from clinically relevant combination treatments with grazoprevir/elbasvir and glecaprevir/pibrentasvir. In genotype 1 infected patients with treatment failure and 156‐RASs, we observed genome‐wide selection of substitutions under treatment. Conclusion : Comprehensive PI resistance profiling for HCV genotypes 1‐6 revealed 156‐RASs as key determinants of high‐level resistance across clinically relevant PIs. We obtained in vitro proof of concept for persistence of highly fit genotype 1‐3 156‐variants, which might pose a threat to clinically relevant combination treatments.
Formalin‐fixed, paraffin‐embedded (FFPE ), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT )‐SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prostate cancer (PC a) and diffuse large B‐cell lymphoma (DLBCL ) samples. We show that the proteome patterns of FFPE PC a tissue samples and their analogous fresh‐frozen (FF ) counterparts have a high degree of similarity and we confirmed multiple proteins consistently regulated in PC a tissues in an independent sample cohort. We further demonstrate temporal stability of proteome patterns from FFPE samples that were stored between 1 and 15 years in a biobank and show a high degree of the proteome pattern similarity between two types of histological regions in small FFPE samples, that is, punched tissue biopsies and thin tissue sections of micrometer thickness, despite the existence of a certain degree of biological variations. Applying the method to two independent DLBCL cohorts, we identified myeloperoxidase, a peroxidase enzyme, as a novel prognostic marker. In summary, this study presents a robust proteomic method to analyze bulk and biopsy FFPE tissues and reports the first systematic comparison of proteome maps generated from FFPE and FF samples. Our data demonstrate the practicality and superiority of FFPE over FF samples for proteome in biomarker discovery. Promising biomarker candidates for PC a and DLBCL have been discovered.
Objectives: Current knowledge on infections caused by Scedosporium spp. and Lomentospora prolificans in children is scarce. We therefore aim to provide an overview of risk groups, clinical manifestation and treatment strategies of these infections.
Methods: Pediatric patients (age ≤18 years) with proven/probable Scedosporium spp. or L. prolificans infection were identified in PubMed and the FungiScope® registry. Data on diagnosis, treatment and outcome were collected.
Results: Fifty-five children (median age 9 years [IQR: 5–14]) with invasive Scedosporium spp. (n = 33) or L. prolificans (n = 22) infection were identified between 1990 and 2019. Malignancy, trauma and near drowning were the most common risk factors. Infections were frequently disseminated. Most patients received systemic antifungal therapy, mainly voriconazole and amphotericin B, plus surgical treatment.
Overall, day 42 mortality was 31%, higher for L. prolificans (50%) compared to Scedosporium spp. (18%). L. prolificans infection was associated with a shorter median survival time compared to Scedosporium spp. (6 days [IQR: 3–28] versus 61 days [IQR: 16–148]). Treatment for malignancy and severe disseminated infection were associated with particularly poor outcome (HR 8.33 [95% CI 1.35–51.40] and HR 6.12 [95% CI 1.52–24.66], respectively). Voriconazole use at any time and surgery for antifungal treatment were associated with improved clinical outcome (HR 0.33 [95% CI 0.11–0.99] and HR 0.09 [95% CI 0.02–0.40], respectively).
Conclusions: Scedosporium spp. and L. prolificans infections in children are associated with high mortality despite comprehensive antifungal therapy. Voriconazole usage and surgical intervention are associated with successful outcome.
High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease
(2019)
Respiratory complex I is a redox-driven proton pump, accounting for a large part of the electrochemical gradient that powers mitochondrial adenosine triphosphate synthesis. Complex I dysfunction is associated with severe human diseases. Assembly of the one-megadalton complex I in the inner mitochondrial membrane requires assembly factors and chaperones. We have determined the structure of complex I from the aerobic yeast Yarrowia lipolytica by electron cryo-microscopy at 3.2-Å resolution. A ubiquinone molecule was identified in the access path to the active site. The electron cryo-microscopy structure indicated an unusual lipid-protein arrangement at the junction of membrane and matrix arms that was confirmed by molecular simulations. The structure of a complex I mutant and an assembly intermediate provide detailed molecular insights into the cause of a hereditary complex I-linked disease and complex I assembly in the inner mitochondrial membrane.
Rationale: RBPs (RNA binding proteins) play critical roles in the cell by regulating mRNA transport, splicing, editing, and stability. The RBP SRSF3 (serine/arginine-rich splicing factor 3) is essential for blastocyst formation and for proper liver development and function. However, its role in the heart has not been explored.
Objective:To investigate the role of SRSF3 in cardiac function.
Methods and Results: Cardiac SRSF3 expression was high at mid gestation and decreased during late embryonic development. Mice lacking SRSF3 in the embryonic heart showed impaired cardiomyocyte proliferation and died in utero. In the adult heart, SRSF3 expression was reduced after myocardial infarction, suggesting a possible role in cardiac homeostasis. To determine the role of this RBP in the adult heart, we used an inducible, cardiomyocyte-specific SRSF3 knockout mouse model. After SRSF3 depletion in cardiomyocytes, mice developed severe systolic dysfunction that resulted in death within 8 days. RNA-Seq analysis revealed downregulation of mRNAs encoding sarcomeric and calcium handling proteins. Cardiomyocyte-specific SRSF3 knockout mice also showed evidence of alternative splicing of mTOR (mammalian target of rapamycin) mRNA, generating a shorter protein isoform lacking catalytic activity. This was associated with decreased phosphorylation of 4E-BP1 (eIF4E-binding protein 1), a protein that binds to eIF4E (eukaryotic translation initiation factor 4E) and prevents mRNA decapping. Consequently, we found increased decapping of mRNAs encoding proteins involved in cardiac contraction. Decapping was partially reversed by mTOR activation.
Conclusions: We show that cardiomyocyte-specific loss of SRSF3 expression results in decapping of critical mRNAs involved in cardiac contraction. The molecular mechanism underlying this effect likely involves the generation of a short mTOR isoform by alternative splicing, resulting in reduced 4E-BP1 phosphorylation. The identification of mRNA decapping as a mechanism of systolic heart failure may open the way to the development of urgently needed therapeutic tools.
Introduction: Despite the poor prognosis for adults with relapsed or refractory (RR) Philadelphia chromosome (Ph)-negative B cell precursor acute lymphoblastic leukemia (ALL), long-term survival is possible and may even be considered as "cure".
Methods: This study used a Delphi panel approach to explore concepts of cure in RR Ph-negative B cell precursor ALL. Ten European experts in this disease area participated in a survey and face-to-face panel meeting.
Results: Findings showed that clinicians conceptualize "cure" as a combination of three broad treatment outcomes that vary depending on the treatment stage: complete remission early in treatment (1–3 months) indicates initial success; eradicating cancer cells (minimal residual disease negative status) consolidates the early clinical response; leukemia-free survival is required in the long term.
Conclusions: Although such terminology remains contested, clinicians would begin considering "cure" as early as 2 years provided the patient is off therapy, with most considering the term applicable by the third year.
Funding: Amgen Inc.
Background: Remote monitoring is an established, guideline-recommended technology with unequivocal clinical benefits; however, its ability to improve survival is contradictory.
Objective: The aim of our study was to investigate the effects of remote monitoring on mortality in an optimally treated heart failure patient population undergoing cardiac resynchronization defibrillator therapy (CRT-D) implantation in a large-volume tertiary referral center.
Methods: The population of this single-center, retrospective, observational study included 231 consecutive patients receiving CRT-D devices in the Medical Centre of the Hungarian Defence Forces (Budapest, Hungary) from January 2011 to June 2016. Clinical outcomes were compared between patients on remote monitoring and conventional follow-up.
Results: The mean follow-up time was 28.4 (SD 18.1) months. Patients on remote monitoring were more likely to have atrial fibrillation, received heart failure management at our dedicated heart failure outpatient clinic more often, and have a slightly lower functional capacity. Crude all-cause mortality of remote-monitored patients was significantly lower compared with patients followed conventionally (hazard ratio [HR] 0.368, 95% CI 0.186-0.727, P=.004). The survival benefit remained statistically significant after adjustment for important baseline parameters (adjusted HR 0.361, 95% CI 0.181-0.722, P=.004).
Conclusions: In this single-center, retrospective study of optimally treated heart failure patients undergoing CRT-D implantation, the use of remote monitoring systems was associated with a significantly better survival rate.
Introduction: The new direct acting antiviral (DAA) therapies are able to effectively treat chronic hepatitis C (CHC). This study elicited the preferences of CHC patients for treatment attributes of new DAAs.
Methods: An online discrete choice experiment survey was designed to collect data from adult CHC patients in the USA, UK, France, Germany, Spain, and Italy. Patients were asked to choose from alternative hypothetical DAA options, defined by differing levels of nine attributes [i.e., treatment duration, tablet count and packaging, cure rate, required office visits when on treatment, modifications to statins or to proton pump inhibitors (PPIs), and risks of diarrhea, headache and nausea]. Logistic regression was used to assess preference for the treatment options.
Results: A total of 328 patients with CHC completed the survey (USA, n = 227; European countries, n = 101), with a mean age of 47.7 years (SD = 14.4) and an average 11.2 years since CHC diagnosis; 51% of patients were female. More than half (60%) of the patients had treatment for CHC. Patients significantly preferred a DAA regimen with higher cure rate, shorter treatment duration, lower risks of diarrhea, headache, and nausea (all p < 0.001), reduced need for office visits when on treatment (p = 0.044), and without requiring dose reduction or timing change in PPIs (p = 0.032). Tablet counts were not found to be statistically significant.
Conclusion: Given the overall high cure rates of new DAAs, CHC patients' preferences for therapy may be influenced by treatment attributes other than cure rates and tolerability. Treatments that are more convenient and require less disruption to their daily life (e.g., shorter treatment duration, no modification in PPI use, and fewer office visits when on treatment) are important to patients with CHC and should be considered when making treatment decisions.
Rhabdomyosarcomas are the most common pediatric soft tissue sarcoma and are a major cause of death from cancer in young patients requiring new treatment options to improve outcomes. High-risk patients include those with metastatic or relapsed disease and tumors with PAX3-FOXO1 fusion genes that encode a potent transcription factor that drives tumourigenesis through transcriptional reprogramming. Polo-Like Kinase-1 (PLK1) is a serine/threonine kinase that phosphorylates a wide range of target substrates and alters their activity. PLK1 functions as a pleiotropic master regulator of mitosis and regulates DNA replication after stress. Taken together with high levels of expression that correlate with poor outcomes in many cancers, including rhabdomyosarcomas, it is an attractive therapeutic target. This is supported in rhabdomyosarcoma models by characterization of molecular and phenotypic effects of reducing and inhibiting PLK1, including changes to the PAX3-FOXO1 fusion protein. However, as tumor re-growth has been observed, combination strategies are required. Here we review preclinical evidence and consider biological rationale for PLK1 inhibition in combination with drugs that promote apoptosis, interfere with activity of PAX3-FOXO1 and are synergistic with microtubule-destabilizing drugs such as vincristine. The preclinical effects of low doses of the PLK1 inhibitor volasertib in combination with vincristine, which is widely used in rhabdomyosarcoma treatment, show particular promise in light of recent clinical data in the pediatric setting that support achievable volasertib doses predicted to be effective. Further development of novel therapeutic strategies including PLK1 inhibition may ultimately benefit young patients with rhabdomyosarcoma and other cancers.