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The purpose of this study of early social-cognitive development was to assess the very young child's behaviorally expressed knowledge of people's visual-attentional acts and abilities. Boys and girls (N = 60) 1, 1 1/2, 2, 2 1/2, and 3 years of age were tested in their homes with their mothers' help. Three sorts of tasks were used: 1. Percept production. The child's task was to produce a visual percept in the other. Examples include pointing to objects ("productive pointing") and a wide variety of object-showing problems. 2. Percept deprivation. The opposite, exemplified by a variety of object-hiding problems. 3. Percept diagnosis. The child's task was to determine what the other was already visually attending to, either by looking where his or her finger was pointed ("receptive pointing") or where his eyes were directed. It was found that the majority of l-year-olds produced and comprehended pointing, and would sometimes hold out a toy to show it, but did little else. The 3-year-olds were at ceiling on virtually all tasks. At 1 1/2 years, children usually showed a picture by holding it flat so that both they and the other could see it. From 2 on, they usually turned it toward the other in the adult fashion. Very few children of any age showed egocentrically - i.e., orienting the picture so only they could see it. By age 2, the children solved what were presumably novel showing problems for them: e.g., successfully showing to another a picture pasted on the inside bottom of a hollow cube. Hiding ability emerged later than showing ability but seemed well established by age 3. The role of the other's eyes in seeing appeared to be quite well understood at least by age 2-2 1/2. As examples, children of this age took the other's hands away from her or his eyes before trying to show her something, and could usually tell where she was looking from her eye orientation alone. These age trends presumably reflect important developments in the area of social interaction and communication, as well as with respect to cognition about percepts.
The focus of this paper is the perspectivization of thematic roles generally and the recipient role specifically. Whereas perspective is defined here as the representation of something for someone from a given position (Sandig 1996: 37), perspectivization refers to the verbalization of a situation in the speech generation process (Storrer 1996: 233). In a prototypical act of giving, for example, the focus of perception (the attention of the external observer) may be on the person who gives (agent), the transferred object (patient) or the person who receives the transferred object (recipient). The languages of the world provide differing linguistic means to perspectivize such an act of giving, or better: to perspectivize the participants of such an action. In this article, the linguistic means of three selected continental West Germanic languages –German, Dutch and Luxembourgish– will be taken into consideration, with an emphasis on the perspectivization of the recipient role.
One of the byproducts of World War II of which society is hardly aware is the new stage of development which the social sciences have reached. This development indeed may prove to be as revolutionary at the atom bomb. Applying cultural anthropology to modern rather than "primitive" cultures, experimentation with groups inside and outside the laboratory, the measurement of sociopsychological aspects of large social bodies, the combination of economic, cultural, and psychological fact-finding, all of these developments started before the war. But, by providing unprecedented facilities and by demanding realistic and workable solutions to scientific problems, the war has accelerated greatly the change of social sciences to a new development level. The scientific aspects of this development center around three objectives: (1) Integrating social sciences. (2) Moving from the description of social bodies to dynamic problems of changing group life. (3) Developing new instruments and techniques of· social research. Theoretical progress has hardly kept pace with the development of techniques. It is, however, as true for the social as for the physical and biological sciences that without adequate conceptual development, science cannot proceed beyond a certain stage. It is an important step forward that the hostility to theorizing which dominated a number of social sciences ten years ago has all but vanished. It has been replaced by a relatively wide-spread recognition of the necessity for developing better concepts and higher levels of theory. The theoretical development will have to proceed rather rapidly if social science is to reach that level of practical usefulness which society needs for winning the race against the destructive capacities set free by man's use of the llatural sciences. I should like to survey certain concepts and theories which have emerged mainly from experimental research. They concern: (a) Quasi-stationary social equilibria and social changes. (b) Locomotion through social channels. (c) Social feedback processes and social management. The last two of these will be dealt with in a later article. A cursory introductory discussion of certain aspects of the present state of affairs in social science is included here for those readers who are interested in the general background of these concepts and in the problems from which they have sprung.
Six species of the genus Polyplectropns are recorded from the People's Republic of China. All the species are new to science. A key to the males is given. The larva of Polyplectropns nanjingensis sp. nov. is illustrated. The phylogenetic relationships among these species and with Polyplectropns species of the New World are discussed.
The phylogenetic relationships of the species of Padunielia are analyzed based on characters of larvae, pupae, and adults (mainly male genitalia). The genus is monophyletic and most closely related to Psychomyia, and Metalype in the subfamily Psychomyiinae. Nine species groups are suggested. Eight species, including six new to science, are reported from the People's Republic of China for the first time.
In this study the rich variety of fossil microorganisms and other ultrastruchlres in the Messel oil shale is documented. The taphonomy of the micro- and the macro organisms is discussed and a basic model for microbial life in the Eocene Lake Messel is proposed. Documentation of the Messel microbiota was made using a scanning electron microscope fitted with an energy-dispersive X-ray analyzer, and a transmission electron microscope. The most common objects discovered were fossil bacteria in the form of cocci, coccobacilli, bacilli, curved rods and filaments, preserved as moulds, crusts, casts, encrusted casts and clay-coated casts. The main lithifying mineral is apatite, followed by siderite. The bacteria occur on fossil remains of macroorganisms. Sideritic bacteria are usually found on keratinous substrates, whereas apatitic bacteria occur preferentially on fish remains. Lithification of the bacteria was selective. It is suggested that the preserved bacteria were heterotrophic, Gram-positive anaerobes, which may have belonged to the group of clostridians.
Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer and pulmonary LAM, especially during early stages. Herein, we present a case of a 66-year-old man with a small nodule in the right upper lobe that was first diagnosed as a lung malignancy using a chest CT scan. After a wedge dissection, a pathologist performed a histologic and immunohistochemical examination, and a diagnosis of pulmonary LAM was made. We further performed a 518-gene panel analysis using next-generation sequencing, and only three genes, BARD1, BLM, and BRCA2, were found to have mutations. We also provide a summary of the diagnosis and treatment of this disease.
The goals of this exercise are essentially threefold: (1) to rescrutinize, archaeologically, epigraphically and linguistically, the pre-Roman inscriptions of the justly famous Negau A and B helmets, (2) to identify "eastward graphemic drift" in preRoman northern Italy and (3) to reconsider and perhaps identify the origin of the Germanic runes in light of (1) and (2). While moving toward these goals, we cite but a sampling of the burgeoning literature, some of which may not be generally known or easily accessible, in these rapidly expanding venues; see Ellis (1998) for a recent overview in English.
The Sclerocoelus galapagensis group is defined and revised, including the description of S. galapagensis new species from the Galapagos Islands; S. caribensis new species from the Caribbean and adjacent areas; S. brasilensis new species from Brazil, Ecuador, Colombia, and Panama; S. hemorrhoidal is new species from Ecuador and Venezuela; and S. andensis new species from Argentina, Bolivia, and Venezuela. The south Atlantic species Sclerocoelus subbrevipennis (Frey), new combination, is redescribed as a member of the S. galapagensis group, and is considered the sister species to the rest of the species group. A key to species, character matrix, and cladogram are provided.
The bromodomain and PHD-finger containing transcription factor (BPTF) is part of the nucleosome remodeling factor (NURF) complex and has been implicated in multiple cancer types. Here, we report the discovery of a potent and selective chemical probe targeting the bromodomain of BPTF with an attractive pharmacokinetic profile enabling cellular and in vivo experiments in mice. Microarray-based transcriptomics in presence of the probe in two lung cancer cell lines revealed only minor effects on the transcriptome. Profiling against a panel of cancer cell lines revealed that the antiproliferative effect does not correlate with BPTF dependency score in depletion screens. Both observations and the multi-domain architecture of BPTF suggest that depleting the protein by proteolysis targeting chimeras (PROTACs) could be a promising strategy to target cancer cell proliferation. We envision that the presented chemical probe and the related negative control will enable the research community to further explore scientific hypotheses with respect to BPTF bromodomain inhibition.
This paper proposes a new sound rule for Proto-Slavic, according to which *g (from PIE *g, *gw, *gh, and *gwh) was lost before *m. This development was posterior to Winter’s law and the merger of voiced and aspirated stop in Slavic. The operation of the rule is illustrated by new etymologies of four Slavic words: *ama, *jama ‘hole, pit’, *těmę ‘sinciput’, *mąžь ‘husband, man’, and *remy ‘leather belt’.
Giulio Camillo (1480 - 1544) was as well-known in his era as Bill Gates is now. Just like Gates he cherished a vision of a universal Storage and Retrieval System, and just like Microsoft Windows, his ‘Theatre of the Memory’ was, despite constant revision, never completed. Camillo’s legendary Theatre of Memory remained only a fragment, its benefits only an option for the future. When it was finished, the user - so he predicted - would have access to the knowledge of the whole universe. On account of his promising invention, Camillo’s contemporaries called him ‘the divine’. For others, like Erasmus or the Parisian scholars, he was just a ‘quack’, but also this only shows that his reception was as strong as is the case with the computer gurus of our days. Still, Camillo was forgotten immediately after his death. No trace is left of his spectacular databank - except a short treatise which he dictated on his deathbed and which was formulated in the future tense: ‘L’Idea del Theatro’ (1550). ...
In the ignorance which still prevails regarding many details of the breeding-habits of the Cuckoo, we have a goof object lesson of how well Nature is able to guard her secrets, since, after years of careful and methodical investigation by distinguished naturalists, comparatively few authentic facts have been established. ...
Covalent inhibition has become more accepted in the past two decades, as illustrated by the clinical approval of several irreversible inhibitors designed to covalently modify their target. Elucidation of the structure-activity relationship and potency of such inhibitors requires a detailed kinetic evaluation. Here, we elucidate the relationship between the experimental read-out and the underlying inhibitor binding kinetics. Interactive kinetic simulation scripts are employed to highlight the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby showcasing which assumptions and corrections are crucial. Four stepwise protocols to assess the biochemical potency of (ir)reversible covalent enzyme inhibitors targeting a nucleophilic active site residue are included, with accompanying data analysis tailored to the covalent binding mode. Together, this will serve as a guide to make an educated decision regarding the most suitable method to assess covalent inhibition potency. © 2022 The Authors. Current Protocols published by Wiley Periodicals LLC.