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Einstein’s theory of general relativity is often regarded as the best theory of gravity that we know. Yet, this theory often manifests itself under conditions where no symmetry is present and nonlinear dynamics dominates. I will discuss how these conditions are systematically accompanied by the restoration of some degree of symmetry. Hence, despite gravity appearing often under conditions devoid of symmetry, asymptotic solutions tend to restore symmetry.
The human immunodeficiency virus (HIV) is currently ranked sixth in the worldwide causes of death [1]. One treatment approach is to inhibit reverse transcriptase (RT), an enzyme essential for reverse transcription of viral RNA into DNA before integration into the host genome [2]. By using non-nucleoside RT inhibitors (NNRTIs) [3], which target an allosteric binding site, major side effects can be evaded. Unfortunately, high genetic variability of HIV in combination with selection pressure introduced by drug treatment enables the virus to develop resistance against this drug class by developing point mutations. This situation necessitates treatment with alternative NNRTIs that target the particular RT mutants encountered in a patient.
Previously, proteochemometric approaches have demonstrated some success in predicting binding of particular NNRTIs to individual mutants; however a structurebased approach may help to further improve the predictive success of such models. Hence, our aim is to rationalize the experimental activity of known NNRTIs against a variety of RT mutants by combining molecular modeling, long-timescale atomistic molecular dynamics (MD) simulation sampling and ensemble docking. Initial control experiments on known inhibitor-RT mutant complexes using this protocol were successful, and the predictivity for further complexes is currently being evaluated. In addition to predictive power, MD simulations of multiple RT mutants are providing fundamental insight into the dynamics of the allosteric NNRTI binding site which is useful for the design of future inhibitors. Overall, work of this type is hoped to contribute to the development of predictive efficacy models for individual patients, and hence towards personalized HIV treatment options.
We report on the event-by-event multiplicity fluctuations of identified particles in central Pb+Pb collisions measured by the NA49 experiment at the CERN SPS. Employing a novel approach we unfolded the moments of the unknown multiplicity distributions of protons (p), kaons (K), pions (π) and electrons. Using these moments we reconstructed an excitation function of the fluctuation measure νdyn[A;B], with A and B denoting different particle types. Specifically, we reconstructed νdyn for the [p, π], [p, K] and [K, π] pairs. The energy dependence of νdyn is in agreement with previously published NA49 results on the related measure σdyn. Moreover, for [K; p] and [K;p] pairs, we discovered a dependence of the fluctuation measure νdyn on the phase space coverage (acceptance). Interestingly for the [p,π] case no significant acceptance dependence was observed. These observations provide a likely explanation of the reported differences between measurements of NA49 and those of STAR in central Au+Au collisions.
GSI High Energy Beam Transfer lines (HEST) link the SIS18 synchrotron with two storage rings (Experimental Storage Ring and Cryring) and six experimental caves. The recent upgrades to HEST beam instrumentation enables precise measurements of beam properties along the lines and allow for faster and more precise beams setup on targets. Preliminary results of some of the measurements performed during runs in 2018 and 2019 are presented here. The focus is on response matrix measurements and quadrupole scans performed on HADES beam line. The errors and future improvements are discussed.
We derive the Polyakov-loop thermodynamic potential in the perturbative approach to pure SU(3) Yang-Mills theory. The potential expressed in terms of the Polyakov loop in the fundamental representation corresponds to that of the strong-coupling expansion, of which the relevant coefficients of the gluon energy distribution are specified by characters of the SU(3) group. At high temperature, the potential exhibits the correct asymptotic behavior, whereas at low temperature, it disfavors gluons as appropriate dynamical degrees of freedom. To quantify the Yang-Mills thermodynamics in confined phase, we introduce a hybrid approach which matches the effective gluon potential to that of glueballs, constrained by the QCD trace anomaly in terms of dilaton fields.
The SIS300 synchrotron, planned for the new Facility for Antiproton and Ion Research (FAIR) at GSI-Darmstadt, will become the first superconducting synchrotron worldwide using cos(θ) magnets for resonant slow extraction. A multi-objective optimization algorithm has been developed for the design of the non-linear magnet scheme. The optimization algorithm makes use of the analytical model for the slow extraction from Kobayashi, the analytical description of the resonance excitation and amplitude-dependent tune-shift from Bengtsson, and corrects the chromaticity in order to fulfill the Hardt condition. As a result, the placement of the chromatic and harmonic sextupole magnets in SIS300, the number of sextupole families and the gradients of these families have been optimized for a high efficiency slow extraction. The algorithm accounts also for the sextupole errors on the dipole magnets, compensating its effects. Furthermore, optimized time-dependent settings for the sextupole magnets are generated to compensate the persistent current decay occurring at slow extraction. Tolerances for the magnets are set for the limits where the compensation is no longer valid.
The modern phase diagram of strongly interacting matter reveals a rich structure at high-densities
due to phase transitions related to the chiral symmetry of quantum chromodynamics (QCD) and
the phenomenon of color superconductivity. These exotic phases have a significant impact on
high-density astrophysics, such as the properties of neutron stars, and the evolution of astrophysical systems as proto-neutron stars, core-collapse supernovae and neutron star mergers. Most recent pulsar mass measurements and constraints on neutron star radii are critically discussed.
Astrophysical signals for exotic matter and phase transitions in high-density matter proposed recently in the literature are outlined. A strong first order phase transition leads to the emergence of a third family of compact stars besides white dwarfs and neutron stars. The different microphysics of quark matter results in an enhanced r-mode stability window for rotating compact stars compared to normal neutron stars. Future telescope and satellite data will be used to extract signals from phase transitions in dense matter in the heavens and will reveal properties of the phases of dense QCD. Spectral line profiles out of x-ray bursts will determine the mass-radius ratio of compact stars. Gravitational wave patterns from collapsing neutron stars or neutron star mergers will even be able to constrain the stiffness of the quark matter equation of state. Future astrophysical data can therefore provide a crucial cross-check to the exploration of the QCD phase diagram with the heavy-ion program of the CBM detector at the FAIR facility.
We present SU(3) lattice Yang-Mills data for hybrid static potentials from five ensembles with different small lattice spacings and the corresponding parametrizations for quark-antiquark separations 0.08fm≤r≤1.12fm. We remove lattice discretization errors at tree level of perturbation theory and partly at order a2 as well as the a-dependent self energy. In particular the tree-level improvement of static potentials is discussed in detail and two methods are compared. The resulting parametrizations are expected to represent continuum limit results for hybrid static potentials within statistical errors.
For the injector upgrade at FNAL a 4-rod Radio Frequency Quadrupole (RFQ) with a resonance frequency of 200 MHz has been build. With this short structure of only 1.3 m a very compact injector design has been realized. Simulations with CST Microwave Studio® were performed for the design. Their results leading to the RF characterizations of the RFQ and the final RF setup which has been accomplished at IAP of the Goethe-University Frankfurt are presented in this paper.
CMOS sensors are the most promising candidates for the Micro-Vertex-Detector (MVD) of the CBM experiment at GSI, as they provide an unprecedented compromise between spatial resolution, low material budget, adequate radiation tolerance and readout speed. To study the integration of these sensors into a detector module, a so-called MVD-demonstrator has been developed. The demonstrator and its in-beam performance will be presented and discussed in this work.