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- heavy-ion collisions (18)
- household finance (18)
- mTOR (18)
- memory (18)
- mortality (18)
- proliferation (18)
- tumor microenvironment (18)
- water-filtered infrared-A (wIRA) (18)
- ALICE (17)
- Afrotropical Region (17)
- Aging (17)
- Alltag (17)
- Anthropozän (17)
- Arbeiterinnenbewegung (17)
- Auchenorrhyncha (17)
- Autobiografische Literatur (17)
- Börsenzulassung (17)
- Cambodia (17)
- Comicroman (17)
- Computer (17)
- Emanzipation (17)
- Escola de Frankfurt (17)
- Essay (17)
- Etymologie (17)
- Fagus sylvatica (17)
- Fehler (17)
- Filmographie (17)
- Florida (17)
- Französische Revolution (17)
- Freie Gewerkschaft (17)
- Frühe Neuzeit (17)
- Frühneuhochdeutsch (17)
- Grillparzer, Franz (17)
- Gutzkow, Karl (17)
- Horrorfilm (17)
- Industriearbeiterin (17)
- Islamismus (17)
- Judentum (17)
- Kajkavisch (17)
- Kapitalmarktrecht (17)
- Marx, Karl (17)
- Methode (17)
- Mundart (17)
- Natur <Motiv> (17)
- Oesterle, Günter (17)
- Photographie (17)
- Presse (17)
- Professionalisierung (17)
- Rezensionen (17)
- Schriftstellerin (17)
- Schule (17)
- Shakespeare, William (17)
- Social System (17)
- Spieltheorie (17)
- Sprachkritik (17)
- Sprachpolitik (17)
- Sprachverstehen (17)
- Stilistik (17)
- Surgery (17)
- Synergie (17)
- Tabu (17)
- Teoria crítica (17)
- Textverstehen (17)
- Topikalisierung (17)
- Verlag (17)
- Vielfalt (17)
- Wertpapieremission (17)
- Wettbewerb (17)
- Wirklichkeit (17)
- climate (17)
- endothelial cells (17)
- gene therapy (17)
- glioma (17)
- host plants (17)
- new genera (17)
- parasitoid (17)
- phenology (17)
- schizophrenia (17)
- stroke (17)
- treatment (17)
- vegetation classification (17)
- Adverb (16)
- Angiogenesis (16)
- Anthologie (16)
- Asia (16)
- Biogeography (16)
- Biomarkers (16)
- Caribbean (16)
- CiNyungwe (16)
- Datenschutz (16)
- Distribution (16)
- EBA (16)
- Euro (16)
- Finanzwirtschaft (16)
- Fiscal Policy (16)
- Gene expression (16)
- Genossenschaftsbewegung (16)
- Geschichte 1800-1900 (16)
- Gesprochene Sprache (16)
- Gewerkverein der Heimarbeiterinnen Deutschlands für Kleider- und Wäschekonfektion und verwandte Berufe (1900-) (16)
- Gleichberechtigung (16)
- Grammatikalisation (16)
- Grammatiktheorie (16)
- Grass, Günter (16)
- Hausarbeit (16)
- Hegel, Georg Wilhelm Friedrich (16)
- Herrschaft (16)
- Industriearbeit (16)
- Infektionsabwehr (16)
- Infrarot (16)
- Journalismus (16)
- Kasus (16)
- Kollokation (16)
- Koti (16)
- Kreditwesen (16)
- Krim (16)
- Magnetic resonance imaging (16)
- Memory (16)
- Migration <Motiv> (16)
- Modellierung (16)
- Mähren (16)
- Müller, Heiner (16)
- Nachlass (16)
- Nibelungenlied (16)
- Nordrhein-Westfalen (16)
- Nyungwe (16)
- Open Access (16)
- Outcome (16)
- Preußen (16)
- Prostitution (16)
- Pädagogik (16)
- QCD (16)
- Selbstdarstellung (16)
- Sicherheit (16)
- Sicherheitspolitik (16)
- Sprachstatistik (16)
- Stadt <Motiv> (16)
- Synthesis (16)
- Systematics (16)
- Terminologie (16)
- Transparenz (16)
- Transylvanian Saxons (16)
- Ungarisch (16)
- Unternehmen (16)
- Vergleich (16)
- Wahlkampf (16)
- X-ray crystallography (16)
- Zeitung (16)
- asset pricing (16)
- cryptic species (16)
- culture (16)
- financial stability (16)
- gene expression (16)
- hippocampus (16)
- inflation (16)
- key to species (16)
- miRNA (16)
- multiple sclerosis (16)
- ordination (16)
- oxidative stress (16)
- populism (16)
- proteomics (16)
- terrorism (16)
- uncertainty (16)
- word order (16)
- Ägypten (16)
- Alphabetisierung (15)
- Altgermanistik (15)
- Arbeitslosigkeit (15)
- Australia (15)
- Außenpolitik (15)
- Bildnis (15)
- Börne, Ludwig (15)
- Carabidae (15)
- Children (15)
- Chuwabu (15)
- Cirrhosis (15)
- Contagion (15)
- Culture (15)
- Das Ganze (15)
- Demography (15)
- EKoti (15)
- Echuwabo (15)
- Erzählforschung (15)
- Finanzierung (15)
- France (15)
- Fußball (15)
- Gefühl <Motiv> (15)
- Heavy-ion collisions (15)
- Historismus (15)
- Hochschuldidaktik (15)
- Hochschule (15)
- Hymenoptera (15)
- ISIS (15)
- Ideologie (15)
- Immunology (15)
- Indogermanische Sprachen (15)
- Interkulturelles Lernen (15)
- Interrogativsatz (15)
- Jean Paul (15)
- Klima (15)
- Konsumgenossenschaft (15)
- Korruption (15)
- Kritische Theorie (15)
- Kulturanthropologie (15)
- Kulturwissenschaft (15)
- Kulturwissenschaftliche Bibliothek Warburg (15)
- Landarbeiterin (15)
- Lehrbuch (15)
- Lepidoptera (15)
- Literaturgeschichte (15)
- Machine Learning (15)
- Macht (15)
- Maschinelle Übersetzung (15)
- Mimesis (15)
- Mitgliederwerbung (15)
- Morphosyntax (15)
- Muttersprache (15)
- Nachhaltigkeit (15)
- Nachkriegszeit (15)
- Nationalbewusstsein (15)
- Obama (15)
- Palaearctic (15)
- Pension Insurance (15)
- Politische Verfolgung (15)
- Prophetie (15)
- Protest (15)
- QGP (15)
- Quantitative Easing (15)
- Sarawak (15)
- Simulation (15)
- Solvency II (15)
- South Africa (15)
- Sprechakt (15)
- Twitter (15)
- Wahlagitation (SPD) (15)
- Warburg, Aby Moritz (15)
- Westafrika (15)
- Wiederholung (15)
- Wikileaks (15)
- Wolf, Christa (15)
- cytokines (15)
- e +-e − Experiments (15)
- human rights (15)
- introduced species (15)
- lung cancer (15)
- mass spectrometry (15)
- obesity (15)
- parasitoids (15)
- planthopper (15)
- radical prostatectomy (15)
- recognition (15)
- reduction of pain (15)
- review (15)
- structural biology (15)
- systemic risk (15)
- temperature (15)
- teoria crítica (15)
- tissue oxygen partial pressure (15)
- tissue temperature (15)
- Adjunkt <Linguistik> (14)
- Agamben, Giorgio (14)
- Anglizismus (14)
- Arabisch (14)
- Artikulatorische Phonetik (14)
- Asset Pricing (14)
- Aussprache (14)
- Barock (14)
- Bitcoin (14)
- Bulgarisch (14)
- Bürgertum (14)
- Chewa-Sprache (14)
- Chwabo (14)
- Computerspiel (14)
- Cryoelectron microscopy (14)
- DNA (14)
- Döblin, Alfred (14)
- ESR Spectra (14)
- Epistemologie (14)
- Epoche (14)
- Erzählperspektive (14)
- European Central Bank (14)
- Flüchtlinge (14)
- Form (14)
- Fortschritt (14)
- Frieden (14)
- Gattungstheorie (14)
- Gegenwart (14)
- Genossenschaft (14)
- Gentherapie (14)
- Griechenland (14)
- Habermas (14)
- Hadron (14)
- Handel (14)
- Held (14)
- Homosexualität (14)
- Humanismus (14)
- Indien (14)
- Infrastruktur (14)
- Inszenierung (14)
- Israel (14)
- Joyce, James (14)
- Kapitalmarkt (14)
- Kindersprache (14)
- Kommentar (14)
- Krise (14)
- Lernen (14)
- Literarische Gestalt (14)
- Literarische Übersetzung (14)
- Ludwig (14)
- Mathematik (14)
- Molinio-Arrhenatheretea (14)
- Mortality (14)
- Mörike, Eduard (14)
- Mündlichkeit (14)
- Negation (14)
- Neoliberalismus (14)
- New Zealand (14)
- New species (14)
- Nungisch (14)
- Pandemie (14)
- Parkinson’s disease (14)
- Parodie (14)
- Passiv (14)
- Pension (14)
- Philhellenismus (14)
- Private Investment (14)
- Radiotherapy (14)
- Reformation (14)
- Rezeptionsästhetik (14)
- Risikomanagement (14)
- Russia (14)
- Sauerstoffversorgung (14)
- Schwedisch (14)
- Schönheit (14)
- Screening (14)
- Slowakisch (14)
- Sozialer Wandel (14)
- Spitteler, Carl (14)
- Sprachvariante (14)
- Sprichwort (14)
- Strategie (14)
- Subjektivität (14)
- Tastsinn (14)
- Taxonomie (14)
- Terror (14)
- Topographie <Kulturwissenschaft> (14)
- Transfer (14)
- Transformation (14)
- Trauma (14)
- Vokal (14)
- Wagner, Richard (14)
- Walther <von der Vogelweide> (14)
- Weiblichkeit (14)
- Widerstand (14)
- Wissenschaftskommunikation (14)
- Wortschatz (14)
- artificial intelligence (14)
- banking (14)
- cell death (14)
- cirrhosis (14)
- credit risk (14)
- epigenetics (14)
- eutrophication (14)
- extracellular matrix (14)
- financial crisis (14)
- flora (14)
- focus (14)
- insurance (14)
- interculturality (14)
- lectotype (14)
- macrophages (14)
- species delimitation (14)
- tissue blood flow (14)
- ubiquitination (14)
- wound healing (14)
- Analyse (13)
- Andes (13)
- Anti-Utopie (13)
- Apoidea (13)
- Ausländer (13)
- Bachtin, Michail M. (13)
- Barbar <Motiv> (13)
- Bayern (13)
- Biopolitik <Motiv> (13)
- Borges, Jorge Luis (13)
- Bourdieu, Pierre (13)
- Capsule endoscopy (13)
- Clearing (13)
- Cognition (13)
- Croatian language (13)
- Cryptocurrency (13)
- Das Andere (13)
- Deutschlehrer (13)
- Diagnostik (13)
- Ding <Motiv> (13)
- Ecocriticism (13)
- Ecology (13)
- Ecuador (13)
- Energie (13)
- Epidemiology (13)
- Epigenetik (13)
- Faschismus (13)
- Federal Reserve (13)
- Filmtheorie (13)
- Finanzkrise (13)
- Fremdbild (13)
- George, Stefan (13)
- Gesicht <Motiv> (13)
- Großstadt <Motiv> (13)
- HCV (13)
- Habitat (13)
- Heinrich von (13)
- Herder (13)
- Herwegh, Georg (13)
- Identity (13)
- Immunotherapy (13)
- Karikatur (13)
- Kinder- und Hausmärchen (13)
- Kinderschutz (13)
- Klein- und Mittelbetrieb (13)
- Klitisierung (13)
- Kompositum (13)
- Kopula (13)
- Kreativität (13)
- Kulturpolitik (13)
- Lehrmittel (13)
- Literaturkanon (13)
- Luther, Martin (13)
- Mammakarzinom (13)
- Medientheorie (13)
- Middle East (13)
- Moral (13)
- Motivation (13)
- Multikulturelle Gesellschaft (13)
- Multistable figures (13)
- Museum (13)
- NADPH oxidase (13)
- Nation (13)
- Netzpolitik (13)
- Neugriechisch (13)
- Niederländisch (13)
- Oncology (13)
- Oriental Region (13)
- Paul (13)
- Performativität <Kulturwissenschaften> (13)
- Phylogeny (13)
- Possessivität (13)
- Prag (13)
- Predigt (13)
- R2P (13)
- ROS (13)
- Rothacker, Erich (13)
- Römisches Reich (13)
- Saving (13)
- Schrift (13)
- Souveränität (13)
- Spanien (13)
- Sprachgebrauch (13)
- Sprachkompetenz (13)
- Sprachlehrbuch (13)
- Suttner, Bertha von (13)
- Tagalog (13)
- Tanz (13)
- Tastwahrnehmung (13)
- Tempus (13)
- Transylvania (13)
- Ungarn (13)
- Vergangenheitsbewältigung (13)
- Vergesellschaftung (13)
- Verkehr (13)
- Vertrauen (13)
- Volkserzählung (13)
- Zeitgenössische Kunst (13)
- bladder cancer (13)
- caves (13)
- child (13)
- communication (13)
- endemic (13)
- epidemiology (13)
- first record (13)
- fiscal policy (13)
- fungi (13)
- genitalia (13)
- globalization (13)
- hrvatski jezik (13)
- ideology (13)
- islamic state (13)
- liquidity (13)
- meiofauna (13)
- metabolism (13)
- neurodegeneration (13)
- red riječi (13)
- signal transduction (13)
- simulation (13)
- spider (13)
- stress (13)
- survival (13)
- synaptic plasticity (13)
- Öffentlichkeit (13)
- ABS (12)
- Aesthetics (12)
- Afghanistan (12)
- Aktivismus (12)
- Allegorie (12)
- Ambiguität (12)
- Arbeiterinnenfrage (12)
- Arbeiterinnenverein (12)
- Argentina (12)
- Asymmetrische Information (12)
- Auslandsgermanistik (12)
- Autophagy (12)
- Bank Lending (12)
- Behavior (12)
- Berliner Kindheit um neunzehnhundert (12)
- Big Data (12)
- Bioenergetics (12)
- Bloch, Ernst (12)
- Buch (12)
- Börsenrecht (12)
- Bürgerliche Frauenbewegung (12)
- Chronotopos (12)
- Comments disabled (12)
- Consumption (12)
- Datenbank (12)
- Deutsches Sprachgebiet (12)
- Diabetes mellitus (12)
- Divina Commedia (12)
- Dürrenmatt, Friedrich (12)
- Einfühlung (12)
- Endothelial cells (12)
- England (12)
- Familienname (12)
- Faust (12)
- Florenz (12)
- Frauenliteratur (12)
- Germanist (12)
- Geschichte 1450-1650 (12)
- Geschlechterverhältnis (12)
- Gewalt <Motiv> (12)
- Greece (12)
- Grundschule (12)
- Hadron-Hadron scattering (experiments) (12)
- Heros (12)
- Historische Sprachwissenschaft (12)
- History (12)
- Idealisierung (12)
- Intellektueller (12)
- Investmentfonds (12)
- Kamerun (12)
- Kapitalertrag (12)
- Katastrophe <Motiv> (12)
- Kleidung (12)
- Klimaänderung (12)
- Kommunismus (12)
- Konsonant (12)
- Lexikografie (12)
- Massenmedien (12)
- Materialität (12)
- Membranproteine (12)
- MiFID II (12)
- Militär (12)
- Modalverb (12)
- Molecular biology (12)
- Mollusca (12)
- Myanmar (12)
- NMR-Spektroskopie (12)
- Namibia (12)
- Nationalsozialismus <Motiv> (12)
- Neuer Markt (12)
- Ovidius Naso, Publius (12)
- Paratext (12)
- Personenname (12)
- Phänomenologie (12)
- Pinus sylvestris (12)
- Portfolio Selection (12)
- Portugiesisch / Brasilien (12)
- Proust, Marcel (12)
- Psychologie (12)
- Psychology (12)
- Publizistik (12)
- Rechtsradikalismus (12)
- Referenzidentität (12)
- Reise (12)
- Repräsentation (12)
- Revolution (12)
- Rheinland-Pfalz (12)
- Romania (12)
- Rumänien (12)
- Sage (12)
- Sehen (12)
- Semantics (12)
- Sepsis (12)
- Sozialgeschichte (12)
- Spannung (12)
- Stadtentwicklung (12)
- Standardsprache (12)
- Struktur (12)
- Subjekt (12)
- Suffix (12)
- Suicide (12)
- Theodor Adorno (12)
- Topik (12)
- Training (12)
- United States (12)
- Vendée (France) (12)
- Verbreitung (12)
- Vereinte Nationen (12)
- Walser, Robert (12)
- Wirtschaftssprache (12)
- Zeichen (12)
- Zeit <Motiv> (12)
- Zustandsgleichung (12)
- alien species (12)
- alphabetisation (12)
- barcoding (12)
- colorectal cancer (12)
- disturbance (12)
- dry grassland (12)
- financial literacy (12)
- health (12)
- human (12)
- language (12)
- leukemia (12)
- mouse (12)
- new synonym (12)
- orthography (12)
- prevalence (12)
- psoriasis (12)
- restoration (12)
- risk (12)
- semantics (12)
- spiders (12)
- surgery (12)
- syntax (12)
- targeted therapy (12)
- trauma (12)
- validity (12)
- Überwachung (12)
- 5-lipoxygenase (11)
- Ableitung <Linguistik> (11)
- Alphabet (11)
- Alzheimer’s disease (11)
- Anapher <Syntax> (11)
- Arbeitsmarkt (11)
- Arbeitsmarktpolitik (11)
- Archivierung (11)
- Artificial Intelligence (11)
- Arzneimittel (11)
- Aspekt (11)
- Bolivia (11)
- Branching fraction (11)
- Bryophytes (11)
- Bundesverfassungsgericht (11)
- Börsenordnung (11)
- Canguilhem, Georges (11)
- Cerambycidae (11)
- Chatten <Kommunikation> (11)
- Chemotherapy (11)
- Cisena (11)
- Computerphilologie (11)
- Conservation (11)
- Czech Republic (11)
- Derivatives (11)
- Deutsch als Zweitsprache (11)
- Dienstmädchen (11)
- Diplomatie (11)
- Diskriminierung (11)
- Dissertation (11)
- Dokumentation (11)
- Droste-Hülshoff, Annette von (11)
- EGFR (11)
- EIOPA (11)
- Eigenübersetzung (11)
- Einkommensverteilung (11)
- Elektronische Zeitschrift (11)
- Emotions (11)
- Endoscopy (11)
- Europäische Zentralbank (11)
- Evangelischer Arbeiterinnenverein (11)
- Freundschaft (11)
- Geburtenregelung (11)
- Germanistenverband (11)
- Geschichte <Motiv> (11)
- Globalization (11)
- Grimm, Wilhelm (11)
- Guatemala (11)
- Hadron-Hadron Scattering (11)
- Heart failure (11)
- Hegel (11)
- Heidegger, Martin (11)
- Hofmannsthal (11)
- Imagination (11)
- Immunologie (11)
- In vitro (11)
- Inversionsfigur (11)
- Italienbild (11)
- Jahrhundertwende (11)
- Jesus Christus (11)
- Joseph von (11)
- Jürgen Habermas (11)
- Konnotation (11)
- Kontrastive Phraseologie (11)
- Kracauer, Siegfried (11)
- Kredit (11)
- Kulturvermittlung (11)
- Kurzgeschichte (11)
- Lacan, Jacques (11)
- Learning (11)
- Legende (11)
- Leidenschaft (11)
- Liebesbrief (11)
- Life Insurance (11)
- Literaturgattung (11)
- Low Interest Rates (11)
- Makonde-Sprache (11)
- Mali (11)
- Mediterranean (11)
- Melancholie (11)
- Menschenrechte (11)
- Mutterschaft (11)
- Mutterschaftsversicherung (11)
- Optionspreistheorie (11)
- PCR (11)
- Pain (11)
- Peter (11)
- Peter Tauber (11)
- Politische Bildung (11)
- Pop-Kultur (11)
- Prediction (11)
- Preis <Auszeichnung> (11)
- Primary care (11)
- Prostate cancer (11)
- Quark Gluon Plasma (11)
- Quark-Gluon Plasma (11)
- RHIC (11)
- Rechtssprache (11)
- Rousseau, Jean-Jacques (11)
- Saccharomyces cerevisiae (11)
- Scarabaeoidea (11)
- Schizophrenia (11)
- Schutzverantwortung (11)
- Science-Fiction (11)
- Sebald, W. G. (11)
- Seizure (11)
- Selbstbild (11)
- Sena (11)
- Silbe (11)
- Strafrecht (11)
- TLAC (11)
- Textgeschichte (11)
- Theatertheorie (11)
- Tieck, Ludwig (11)
- Tiere <Motiv> (11)
- Transkulturalität (11)
- Uncertainty (11)
- VEGF (11)
- Verfassung (11)
- Verfilmung (11)
- Wahrnehmungswechsel (11)
- Waldgesellschaften (11)
- Weerth, Georg (11)
- Wohnverhältnisse (11)
- Wortfeld (11)
- Zweig, Stefan (11)
- al-Qaida (11)
- asymmetric information (11)
- bees (11)
- biology (11)
- crisis (11)
- deep sea (11)
- exercise (11)
- forest management (11)
- grammar (11)
- grazing (11)
- habitat (11)
- hepatitis C virus (11)
- hydrogen bonding (11)
- infection (11)
- integrins (11)
- intercultural communication (11)
- justice (11)
- macrophage polarization (11)
- magnetic resonance imaging (11)
- male genitalia (11)
- metastasis (11)
- model uncertainty (11)
- morphometry (11)
- outcome (11)
- p53 (11)
- participation (11)
- physical activity (11)
- public debt (11)
- quark gluon plasma (11)
- radiotherapy (11)
- real-time data (11)
- responsibility (11)
- risk factors (11)
- sexual dimorphism (11)
- therapy (11)
- transparency (11)
- vaccination (11)
- vegetation (11)
- Ästhetische Wahrnehmung (11)
- Österreich-Ungarn (11)
- 19. Jahrhundert (10)
- ACLF (10)
- Achtundsechziger (10)
- Aktienkurs (10)
- Anthrozoologie (10)
- Arachnida (10)
- Arbeit <Motiv> (10)
- Arbeitsrecht (10)
- Arbeitsverhältnisse (10)
- Asset Allocation (10)
- Atrial fibrillation (10)
- Autor (10)
- Bankenaufsicht (10)
- Barrierefreiheit (10)
- Barthes, Roland (10)
- Baudelaire, Charles (10)
- Bildungsroman (10)
- Biopolitik (10)
- Boko Haram (10)
- Bratoljub Klaić (10)
- Brustkrebs (10)
- Bundestag (10)
- C. elegans (10)
- CDU (10)
- COPD (10)
- Chile (10)
- Classification (10)
- Costa Rica (10)
- Cyberwar (10)
- Debatte (10)
- Deutsch-Ostafrika (10)
- Diagnostic markers (10)
- Dialektik (10)
- Ding (10)
- Disclosure (10)
- Disticha Catonis (10)
- Diversity (10)
- Educação (10)
- Egypt (10)
- Eichendorff (10)
- Einkommen (10)
- Ellenberg indicator values (10)
- Energieumsatz <Medizin> (10)
- Entstehung (10)
- Erlebnisbericht (10)
- Evolutionspsychologie (10)
- Expressivität <Linguistik> (10)
- Facebook (10)
- Fachinformationsdienst (10)
- Fauna (10)
- Fintech (10)
- Fragebogen (10)
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- Goethe-Universität Frankfurt am Main (10)
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- Recht <Motiv> (10)
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- Lynch, David (Regisseur) (9)
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- Dante, Alighieri (8)
- Der Mann ohne Eigenschaften (8)
- Der Zauberberg (8)
- Developmental biology (8)
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- Nationalsozialistische Deutsche Arbeiterpartei (NSDAP, 1920-) (8)
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- information structure (8)
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- platelets (8)
- polypharmacy (8)
- polytrauma (8)
- precipitation (8)
- pregnancy (8)
- primary care (8)
- problem wounds (8)
- pronunciation (8)
- quark matter (8)
- quark-gluon-plasma (8)
- reconhecimento (8)
- regulatory arbitrage (8)
- reification (8)
- relationship lending (8)
- relationships (8)
- renal cell carcinoma (8)
- screening (8)
- site conditions (8)
- sleep (8)
- solitary bees (8)
- speciation (8)
- species list (8)
- sphingolipids (8)
- sustainability (8)
- systematic review (8)
- taxonomic key (8)
- teacher training (8)
- toxicity (8)
- transcranial magnetic stimulation (8)
- transfer (8)
- ubiquitin (8)
- vegetation structure (8)
- visual cortex (8)
- welfare state (8)
- whiteflies (8)
- wound infections (8)
- Äquivalenz (8)
- 500-1500 (7)
- Ackerunkräuter (7)
- Adaptation (7)
- Aktiengesellschaft (7)
- Aktionär (7)
- Alemão como língua estrangeira (7)
- Alien species (7)
- Allgemeinmedizin (7)
- Alzheimer's disease (7)
- Ambivalenz (7)
- Anpassung (7)
- Anreizsystem (7)
- Anthophila (7)
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- Antifaschismus (7)
- Anura (7)
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- Aphorismus (7)
- Arbeitsvermittlung (7)
- Argumentation (7)
- Atlantic Ocean (7)
- Ausnahmezustand (7)
- Auswanderung (7)
- Autism spectrum disorder (7)
- Azerbaijan (7)
- Baltoslawische Sprachen (7)
- Basidiomycota (7)
- Bayesian estimation (7)
- Behinderung (7)
- Belize (7)
- Benthos (7)
- Bericht (7)
- Beuys, Joseph (7)
- Bindungstheorie <Linguistik> (7)
- Biological invasions (7)
- Biophysical chemistry (7)
- Black holes (7)
- Bobrowski, Johannes (7)
- Brandenburg (7)
- Bremen (7)
- Brüder Grimm (7)
- CRISPR/Cas9 (7)
- Cancer treatment (7)
- Capital-Asset-Pricing-Modell (7)
- Charakterisierung (7)
- Charmonium (7)
- Chemiker (7)
- Chewa (7)
- Chichewa (7)
- Christliche Arbeiterbewegung (7)
- Climate (7)
- Colorectal cancer (7)
- Community ecology (7)
- Computational models (7)
- Consensus (7)
- Corporate Social Responsibility (7)
- Culicidae (7)
- Curculionidae (7)
- Cyanobacteria (7)
- Das Böse (7)
- Das Heilige (7)
- Das Sakrale (7)
- Data processing (7)
- Data science (7)
- Deflation (7)
- Derivat, Wertpapier (7)
- Deutscher Einwanderer (7)
- Deutschland / Vereinigung (7)
- Deutschland <Bundesrepublik> (7)
- Deutschland <DDR> / Revolution <1989> (7)
- Deutschlandbild (7)
- Development (7)
- Dienstmädchenverein (7)
- Digital Rights (7)
- Digital Services Act (7)
- Digitalization (7)
- Dodd-Frank Act (7)
- Drogenkonsum (7)
- Drogenszene (7)
- Drung (7)
- Dung beetles (7)
- EZB (7)
- Eastern Arc (7)
- Eco, Umberto (7)
- Electroencephalography (7)
- Elektronische Bibliothek (7)
- Ellipse <Linguistik> (7)
- Empfindsamkeit (7)
- Empirische Ästhetik (7)
- Engel <Motiv> (7)
- Enzensberger, Hans Magnus (7)
- Epigenetics (7)
- Episches Theater (7)
- Epos (7)
- Erwerbslosigkeit (7)
- Erzähler (7)
- Essayismus (7)
- Ethica ordine geometrico demonstrata (7)
- Ethnizität (7)
- Euro Area (7)
- Europabild (7)
- Expedition Brochure (7)
- Expeditionsbericht (7)
- Exposure (7)
- Fachportal (7)
- Fantastische Literatur (7)
- Fassbinder, Rainer Werner (7)
- Fernunterricht (7)
- Filmkritik (7)
- Finance (7)
- Financial Regulation (7)
- Finanzierungsstruktur (7)
- Flaubert, Gustave (7)
- Foreign language teaching (7)
- Forschungsbericht (7)
- Fragmentation (7)
- Frauenemanzipation (7)
- Frauenpolitik (SDAP) (7)
- Freidenker (7)
- Freie Liebe (7)
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- GARCH (7)
- GIS (7)
- GPCR (7)
- Gegenwartsliteratur (7)
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- Gene regulation (7)
- Genossenschaftliche Frauenbewegung (7)
- Genregulation (7)
- German literature (7)
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- Geschichte 1933-1945 (7)
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- Gesundheitspolitik (7)
- Gewerbeaufsicht (7)
- Goethe-Universität Frankfurt (7)
- Gottsched, Johann Christoph (7)
- Green Finance (7)
- Griechenland (Altertum) (7)
- Guattari, Félix (7)
- HCC (7)
- Harz (7)
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- Husserl, Edmund (7)
- Ich (7)
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- Ikone (7)
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- Indústria cultural (7)
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- Jena (7)
- John (7)
- Johnson, Uwe (7)
- Kannibalismus <Motiv> (7)
- Kapitalgewinn (7)
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- Karl Philipp (7)
- Karriere (7)
- Kasperl (7)
- Katholische Arbeiterinnenbewegung (7)
- Kausalität (7)
- Kenya (7)
- Klopstock, Friedrich Gottlieb (7)
- Komposition <Wortbildung> (7)
- Konfliktlösung (7)
- Kraus, Karl (7)
- Kreditwürdigkeit (7)
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- Kriminalgeschichte (7)
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- Kunstpädagogik (7)
- Kybernetik (7)
- Latein (7)
- Lattice QCD (7)
- Laudatio (7)
- Lebensstil (7)
- Legs (7)
- Leibniz, Gottfried Wilhelm (7)
- Lesekompetenz (7)
- Liberdade (7)
- Linguistische Datenverarbeitung (7)
- Linkshegelianer (7)
- Lycosidae (7)
- MLL (7)
- MSC (7)
- Macaronesia (7)
- Macht <Motiv> (7)
- Machtstruktur (7)
- Makonde (7)
- Malaise trap (7)
- Manga (7)
- Manipulation (7)
- Mann (7)
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- Marcuse (7)
- Martin (7)
- Martyrium (7)
- Marxismus (7)
- Mechanisms of disease (7)
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- Moose (7)
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- Musculoskeletal system (7)
- Märtyrer <Motiv> (7)
- Müller (7)
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- NK cells (7)
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- Nestroy, Johann (7)
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- Numerale (7)
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- Organische Synthese (7)
- Othering (7)
- Outcomes (7)
- PD-L1 (7)
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- PTSD (7)
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- Simmel, Georg (7)
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- Software (7)
- Sozialdemokratische Partei Deutschlands (SPD, 1890-) (7)
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- descriptions (7)
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- perception (7)
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- predictive coding (7)
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- transcription (7)
- transcriptome (7)
- tumor-associated macrophages (7)
- ultrasound (7)
- validation (7)
- vector (7)
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- Ökosystem (7)
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- Kleidung <Motiv> (5)
- Klimaänderung <Motiv> (5)
- Koartikulation (5)
- Kognitionswissenschaft (5)
- Kolonialismus <Motiv> (5)
- Kolonie (5)
- Kommanditgesellschaft auf Aktien (5)
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- Korrelation (5)
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- Kristallisation (5)
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- Lichtenberg, Georg Christoph (5)
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- Liste (5)
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- Liverwort (5)
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- Lukács, Georg (5)
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- MRSA (5)
- Machine-learning (5)
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- Mallarmé, Stéphane (5)
- Mann, Heinrich (5)
- Mann, Thomas / Joseph und seine Brüder (5)
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- Metabolomics (5)
- Meyrink, Gustav (5)
- Michel (5)
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- NO (5)
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- Opitz, Martin (5)
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- Orient <Motiv> (5)
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- Otto-Peters, Louise (5)
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- Paris <Motiv> (5)
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- Predictive markers (5)
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- Prioninae (5)
- Privater Verbrauch (5)
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- Probability distribution (5)
- Produktivität (5)
- Progressive Taxation (5)
- Propaganda (KPD) (5)
- Protein Structure (5)
- Protein folding (5)
- Prädikation (5)
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- Psychiatrie (5)
- Psychiatrie <Motiv> (5)
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- RUCAM (5)
- Raabe, Wilhelm (5)
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- Rationalität (5)
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- Region Rhein-Main (5)
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- Remarque, Erich Maria (5)
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- Revolutionäre Gewerkschaftsopposition (RGO, 1929-) (5)
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- STAT3 (5)
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- Schönberg, Arnold (5)
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- Stirner, Max (5)
- Streptomyces hydrogenans (5)
- Structure (5)
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- Sumatra (5)
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- Teaching (5)
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- Texas (5)
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- Textualität (5)
- Thai (5)
- The Good Samaritan (5)
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- Transcriptome (5)
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- Trauer (5)
- Treatment outcome (5)
- Trichoptera (5)
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- Tumor microenvironment (5)
- Türken (5)
- Türkischer Einwanderer (5)
- Ubiquitin (5)
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- Uganda (5)
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- Wagner, Richard / Tannhäuser (5)
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- Weigel, Sigrid (5)
- Weimarer Beiträge (Zeitschrift) (5)
- Well-being (5)
- Welt (5)
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- Weltkrieg <1914-1918, Motiv> (5)
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- Werfel, Franz (5)
- Wert (5)
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- Wikipedia (5)
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- abundance (5)
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- aptamer (5)
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- catalogue (5)
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- collagen (5)
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- comparison (5)
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- fragmentation (5)
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- gamma (5)
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- lncRNA (5)
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- mPGES-1 (5)
- mRNA (5)
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- measurement (5)
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- similarity (5)
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- topic (5)
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- types (5)
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- werden <Wort> (5)
- yeast (5)
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- zero lower bound (5)
- Ética (5)
- Öffentliche Ausgaben (5)
- Čakavian (5)
- Šalamov, Varlam Tichonovič (5)
- 177Lu-PSMA-617 (4)
- 5-Lipoxygenase (4)
- A clockwork orange (4)
- ABC Transporter (4)
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- AF4 (4)
- ATP (4)
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- Absatzweg (4)
- Aby-M.-Warburg-Preis (4)
- Accounting (4)
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- Adolf Bratoljub Klaić (4)
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- Aesculus hippocastanum (4)
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- Age (4)
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- Agitation (RGO) (4)
- Aichinger, Ilse (4)
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- Analysis (4)
- Anders, Günther (4)
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- Anna Amalia <Sachsen-Weimar-Eisenach, Herzogin> (4)
- Anneke, Mathilde Franziska (4)
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- App <Programm> (4)
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- Bacon, Francis (4)
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- Baden (4)
- Badiou, Alain (4)
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- Barck, Karlheinz (4)
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- Basler Konzil (1431-1449 : Basel) (4)
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- Biller, Maxim (4)
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- Prinz Friedrich von Homburg (4)
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- Protein Translocation (4)
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- QCD equation of state (4)
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- RCT (4)
- RDF (4)
- REM sleep (4)
- RFQ-Beschleuniger (4)
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- Reich (4)
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- Revolution <Motiv> (4)
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- Rječnik stranih riječi (4)
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- Schelling, Friedrich Wilhelm Joseph von (4)
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- Se questo è un uomo (4)
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- Verband Süddeutscher Katholischer Arbeiterinnenvereine (1906-) (4)
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- Frankfurt Institute for Advanced Studies (FIAS) (1775)
- Center for Financial Studies (CFS) (1632)
The utilization of Ginkgo biloba in medicinal practice dates back to 1505 A.D. Ironically, the mechanisms of action of Ginkgo are not fully clarified till now. Nowadays, Ginkgo biloba leaf extracts are mainly indicated for mild to moderate cerebrovascular insufficiency and different forms of dementia. The fact that it is an herbal extract composed of several different components indeed adds to the intricacy of finding its mechanisms of actions. Indisputably, many scientists tried to elucidate the mechanisms of actions of Ginkgo. The first step to achieve this goal was to standardize the leaf extract. The standardized Ginkgo leaf extract contains 22-27 % flavonol glycosides, 2.8-3.4 % of ginkgolide A, B and C, as well as approximately 2.6-3.2 % bilobalide and below 5 ppm ginkgolic acids. A widespread standardized Ginkgo extract is the EGb 761, which was utilized in the current work. One of the earliest proposed mechanisms is the ability of the Ginkgo extract to act as an anti-oxidant, which could be explained by its high flavonoid contents. However, without doubt EGb 761 encompasses other characteristics which distinguish it from other herbal extracts that are also rich in flavonoids. Since free radicals and reactive oxygen species are highly associated with the mitochondrial functions, examination of the effect of EGb 761 on mitochondrial functions was lately addressed. Moreover, this was encouraged as the link between Alzheimer’s disease [AD] and the mitochondria started to emerge. Previously, our group observed mitochondrial protective actions of EGb 761 on cell culture in vitro. Furthermore, anti-apoptotic effects were previously described for EGb 761. However, only very few studies addressed the single constituents and their effect on mitochondrial functions. Flavonoids were studied in several other plant extracts and their radical scavenging activity is unquestionable, but EGb 761 has anti-apoptotic actions which may be attributed to its terpenoid fraction. Exclusively found in the Ginkgo plant, are the ginkgolides and therefore their actions are not yet fully elucidated. Moreover, those who attempted to address these constituents concentrated on one or two candidates, for example bilobalide or ginkgolide B and ignored the rest. Unfortunately, this led to incomplete results, and one couldn’t compare the relative activities of all EGb 761 components in order to state whether all the components are effective or not. ...
Optimal investment decisions by institutional investors require accurate predictions with respect to the development of stock markets. Motivated by previous research that revealed the unsatisfactory performance of existing stock market prediction models, this study proposes a novel prediction approach. Our proposed system combines Artificial Intelligence (AI) with data from Virtual Investment Communities (VICs) and leverages VICs’ ability to support the process of predicting stock markets. An empirical study with two different models using real data shows the potential of the AI-based system with VICs information as an instrument for stock market predictions. VICs can be a valuable addition but our results indicate that this type of data is only helpful in certain market phases.
Artificial Intelligence (AI) and Machine Learning (ML) are currently hot topics in industry and business practice, while management-oriented research disciplines seem reluctant to adopt these sophisticated data analytics methods as research instruments. Even the Information Systems (IS) discipline with its close connections to Computer Science seems to be conservative when conducting empirical research endeavors. To assess the magnitude of the problem and to understand its causes, we conducted a bibliographic review on publications in high-level IS journals. We reviewed 1,838 articles that matched corresponding keyword-queries in journals from the AIS senior scholar basket, Electronic Markets and Decision Support Systems (Ranked B). In addition, we conducted a survey among IS researchers (N = 110). Based on the findings from our sample we evaluate different potential causes that could explain why ML methods are rather underrepresented in top-tier journals and discuss how the IS discipline could successfully incorporate ML methods in research undertakings.
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We now studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. Methods German landrace pigs underwent CPB (60 min myocardial ischemia; 30 min reperfusion)without (group I; n=6) or with LIM (group II; n=6). The cardiac indices (CI) and cardiac function were analyzed pre and post CPB with a Swan-Ganz catheter and the cardiac function analyzer. Neutrophil labeling with technetium, scintigraphy, and histological analyses were done to track activated neutrophils within the organs. Results LIM prevented CPB-associated increase of neutrophil counts in peripheral blood. In group I, the CI significantly declined post CPB (post: 3.26 +/- 0.31; pre: 4.05 +/- 0.45 l/min/m2; p<0.01). In group II, the CI was only slightly reduced (post: 3.86 +/- 0.49; pre 4.21 +/- 1.32 l/min/m2; p=0.23). Post CPB, the intergroup difference showed significantly higher CI values in the LIM group (p<0.05) which was in conjunction with higher pre-load independent endsystolic pressure volume relationship (ESPVR) values (group I: 1.57 +/- 0.18; group II: 1.93 +/- 0.16; p<0.001). Moreover, the systemic vascular resistance and pulmonary vascular resistance were lower in the LIM group. LIM appeared to accelerate the sequestration of hyperactivated neutrophils in the spleen and to reduce neutrophil infiltration of heart and lung. Conclusions Our data provide strong evidence that LIM improves perioperative hemodynamics and cardiac function after CPB by limiting neutrophil activity and inducing accelerated sequestration of neutrophils in the spleen.
Die vorliegende Untersuchung befasst sich mit verschiedenen Aspekten des Frauenbilds sowohl in der deutschen als auch in der arabischen bzw. orientalischen Literatur des Mittelalters.
Zu den untersuchenden Aspekten gehören zum Beispiel die Stellung der Frau in der Gesellschaft sowohl religiös als auch sozial, Rolle und Einfluss der Frau, Beschreibung der Schönheit der Frau, Beziehung zwischen Mann und Frau, Minne als Zentralmotiv, Ehe als sozialbedingte Lebensform sowie adlige Dame und bäuerliche Frau als Gegenbild.
Die Forschung wird sich auf bestimmte Textsorten der mittelalterlichen Literatur stützen, um mittels dieser induktiven Methode ein konkretes Bild zu geben und die verschiedenen Hauptelemente der Untersuchung zu betonen.
Diese Werke sind die klassischen höfischen Artusromane z.B. Erec, Iwein, Parzival und Tristan und Isolde in der deutschen Literatur des Mittelalters sowie Erzählungen aus der Geschichtensammlung von 1001 Nacht, der Antarroman und die Geschichte von Laila und Madjnun in der orientalischen Literatur des Mittelalters.
Das Bild der Frau ist ein Thema, das bis heute ein Schwerpunkt in vielen literarischen Werken bildet, der aber während der gesamten Epoche des Mittelalters eine besondere Bedeutung hatte. Das könnte auf die unterschiedlichen Darstellungsweisen vom Bild der Frau zurückzuführen, und wie sie in den verschiedenen Kulturen zum Ausdruck gebracht werden.
In “Fern von Aleppo”, the Syrian author Faisal Hamdo, who left his home in 2014 and sought refuge in Germany, tells of his very personal integration experiences. The book represents a kind of intercultural communication. In his book, Faisal Hamdo, who sees himself as a “mediator between the worlds”, tries to give the German reader answers to many questions regarding Syrian culture. From a text linguistic point of view, this book identifies the narrative development that seems to be tailored to the in-tercultural context. Accordingly, the present article raises the following questions: Does the structure of classic narration differ from the structure of narration in an intercultural context? Which intercultural information units are presented in the text? How are they embedded in the narrative text? Which constituents of the narrative structure are suitable for realizing intercultural communication? Which communicative functions do the constituents of the narrative structure fulfill in an intercultural context? The contribution sets itself the goal of analyzing the narrative structure to investigate how intercultural communication comes about through narration, how the intercultural information units are integrated into the constituents of the classic narrative structure so that they fulfill their communicative function, and to developa suitable analysis model.
Objective: The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS).
Methods: The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease.
Results: The median cell count and albumin concentration in the CSF did not deviate from normal values. The CSF-serum albumin-quotient (QALB) was elevated in 29.6% of the patients, while intrathecal immunoglobulin G (IgG) oligoclonal bands (OCBs) were detected in 91.1% of the patients. CSF-lactate levels as well as local IgM- and IgA-synthesis were correlated with the yearly disease progression rate, as assessed by EDSS.
Conclusion: We present the results of the hitherto largest and most detailed CSF biomarker profile in a cohort of 254 patients with PPMS. As reported previously, OCBs are the most sensitive marker for intrathecal IgG synthesis. CSF-lactate concentrations are positively correlated with the progression rate, which might suggest that mitochondrial dysfunction plays a relevant role in PPMS. The negative correlation between intrathecally produced IgM and IgA and disease progression may indicate their hitherto unexplored protective role.
18-OH-Corticosteron (18 ) wird als die unmittelbare Vorstufe der Aldosteron-Synthese angesehen. In-vitro-Untersuchungen sowie vereinzelten klinischen Beobachtungen zufolge sollen Nebennierenrinden-Adenome, im Gegensatz zu Nebennierenrinden-Hyperplasie, vermehrt 8- bilden. In der vorliegenden Studie wurde an 1.272 Patienten einer Hochdruckambulanz, wobei bei 84 Patienten mit primärem Aldosteronismus infolge eines Adenoms sowie bei 110 Patienten infolge einer Nebennierenrinden-Hyperplasie die Diagnose gesichert werden konnte, der diagnostische Stellenwert von 8- im Vergleich zu den Aldosteron-Metaboliten Aldosteron-18-Glucuronid (ALD-18-G) und Tetrahydroaldosteron (TH-ALD) untersucht. Dies im Hin blick auf: 1. die Erkennung eines primären Aldosteronismus, und 2. der differentialdiagnostischen Unterscheidung zwischen einem Adenom und einer Hyperpläsie.
Bezüglich der ersten Fragestellung wurde für 18-OHB - hinsichtlich der Unterscheidung zwischen dem primären Aldosteronismus infolge eines Adenoms und einer essentiellen Hypertonie-eine diagnostische Sensitivität von 99,2% bei einer diagnostischen Spezifität von 95,2% berechnet. Deutlich geringer war mit einer diagnostischen Sensitivität von 79,7% bei einer diagnostischen Spezifität von 60,9% die Abgrenzung zwischen dem primären Aldosteronismus infolge einer Hyperpläsie und einer essentiellen Hypertonie.
18-OHB war bei 11 der 84 Adenom- und 5 der 110 Hyperplasie-Patienten zunächst das einzig erhöhte Steroid im 24 h-Urin. Bei ihnen konnte erst innerhalb einer bis zu 2jährigen Beobachtungszeit ein langsamer Anstieg der Aldosteron-Metabolite beobachtet werden. Somit stellt das 18-OHB einen „Frühmarker" der Erkrankung dar.
In der Unterscheidung zwischen einem Nebennierenrinden-Adenom und einer -Hyperplasie besitzt 18-OHB mit einer diagnostischen Sensitivität von 84,5% bei einer diagnostischen Spezifität von 96,4% ein höheres Abgrenzungsvermögen als Tetrahydro-Aldosteron und Aldosteron-18-Glucuronid dar.
Für die Unterscheidung des Adenoms von der Hyperpläsie ließ sich für 18-OH-Corticosteron im 24 h-Urin ein Wert von 7,9 [ig/die als eine optimale Diskriminanzschwelle berechnen. Bei einer höheren Ausscheidung ist in 84,5% der Fälle mit einem Nebennierenrinden-Adenom zu rechnen. Hinsichtlich der diagnostischen Wertung von 18-OHB sind weder geschlechts- noch altersspezifische Abhängigkeiten zu berücksichtigen.
Die Bestimmung von Tetrahydro-Aldosteron (oder Aldosteron-18-Glucuronid) in Kombination mit 18-OH-Corticosteron stellt die optimale Methode zur Diagnostik des primären Hyperaldosteronismus, insbesondere infolge eines Adenoms, dar.
Tibnīn was an important small Crusader fief and a fortified castle. It was vital for the Kingdom of Jerusalem, because it included fertile agricultural lands, was a tax collection centre, and because it controlled the Damascus-to-Tyre commercial route. Additionally, its castle played defensive and offensive role in the north of the Kingdom of Jerusalem and upper Galilee, and its rulers of Tibnīn played a major role in forming the history of the Latin East. When the Crusaders invaded the Levant at the end of the eleventh century, it was given rise to new demographic, cultural, socio-economic, and architectural features. The present Paper aims at removing some of the mystery concerning the fief of Tibnīn and its castle in the Latin East. This paper thus is a study of the demographic structure of Tibnīn and discusses the socio-economic role of Tibnīn in the Latin east. Moreover, the role of Tibnīn in influencing the relations between Muslims and the Crusaders in the Levant and the architecture of the castle of Tibnīn and its importance in the age of the Crusade will be examined.
The Crusade movement is one of the most important occurrences of medieval history. It took place throughout two centuries in the Levant and affected both Muslims and Crusaders and in turn changed the way in which West and East related to one another.1 When the Crusaders took control of the Holy Land and many Islamic cities in the Levant, they transferred their feudal European system there. They established four main fiefdoms or lordships, Jerusalem, Edessa, Antioch and Tripoli. In addition, there were another twelve secondary fiefdoms,2 of which Tibnīn was one. Tibnīn was called “Toron” by the Crusaders. Once the Crusaders had captured Tibnīn, they began building its fortified castle, from which the fief of Tibnīn gained its importance throughout the period of the Crusades.
This paper traces the military role of Tibnīn and its rulers in the Latin East against the Muslims until 1187/ 583. Tibnīn played a key role in overcoming the Muslims in Tyre and controlled it in 1124. It also played a vital role in the conflict between Damascus and the Kingdom of Jerusalem. Tibnīn participated in defending Antioch, Banyas, Hebron and Transjordan several times. Furthermore, its soldiers and Knights joined the army of the Kingdom of Jerusalem to capture Ascalon in 1153, and joined the campaigns of Amaury I, King of Jerusalem, against Egypt from 1164 to1169. The military situation of Tibnīn under the rule of the royal house until its fall to the Muslims in 1187/ 583 will be studied as well.
Die Verwendung von photolabilen Schutzgruppen zur nicht-invasiven Kontrolle von Systemen birgt ein großes Potential für verschiedenste Anwendungsgebiete, die von der Erforschung und Regulation biologischer Prozesse, über den Einsatz in medizinischer Therapie bis hin zur Verwendung als molekulare Datenspeicher reichen. Für diese Umsetzung benötigt es allerdings eine breite Auswahl an entsprechenden PPGs und das Wissen über ihre Reaktionsmechanismen. Im Allgemeinen lässt sich die Konzeptionierung von PPGs in drei Prozesse einteilen, beginnend bei dem Design und der Synthese einer neuen PPG. Bei diesem Schritt liegt der Fokus auf ein oder zwei besonderen Eigenschaften, wie beispielsweise einer Absorptionswellenlänge in einem bestimmten Spektralbereich oder einer hohen Uncaging-Quantenausbeute. Im zweiten Schritt folgt die Untersuchung der PPG bezüglich spektroskopischer und mechanistischer Eigenschaften und ggf. anschließender Optimierung auf synthetischer Ebene. Die so gewonnenen Informationen sind dann hilfreich bei dem letzten Schritt, bei dem es um den Einsatz der PPG in einem entsprechenden System geht. Hierbei müssen die verwendeten PPGs genau auf das Zielsystem abgestimmt sein, dazu zählen verschiedenste Parameter wie Anregungswellenlänge, Extinktionskoeffizient, Art und Struktur der Photoprodukte sowie Uncaging-Effizienz und Geschwindigkeit.
In der vorliegenden Arbeit wurde über die drei vorgestellten Projekte mittels spektroskopischer Methoden zu allen drei genannten Stadien zur Konzeptionierung von PPGs ein Beitrag geleistet. Dazu zählt die Entwicklung der CBT-basierten PPGs, die Untersuchung der Struktur-Wirkungsbeziehung von (DMA)(2)F-PPGs und die Etablierung einer wellenlängenselektiven An-/Aus-Funktionalität eines Antibiotikums. In enger interdisziplinärer Zusammenarbeit zwischen theoretischen, synthetischen und biologischen Teilgebieten konnte jedes Projekt innerhalb der jeweiligen Entwicklungsstufe erfolgreich abgeschlossen werden.
Mithilfe des relativ neuen Ansatzes, bei dem durch quantenmechanische Berechnungen der vertikalen Anregungsenergie von der kationischen Spezies einer PPG-Grundstruktur eine Aussage über ihre Qualität postuliert werden kann, konnte ausgehend von der Fluoren-Grundstruktur eine neue Klasse von PPGs gefunden werden. Dabei erwies sich die CBT-Struktur mit den Schwefelatomen an der para-Position als besonders geeignet. Insbesondere konnte die Grundstruktur durch die (OMePh)2-Substitution, welche in einer signifikanten bathochromen Verschiebung des Absorptionsmaximums resultierte, optimiert werden. Die Untersuchung der Ultrakurzzeit-Dynamik beider p-CBT Strukturen gab Aufschluss über die unterschiedlichen photochemischen Eigenschaften als PPG.
Für die Stoffklasse der Dimethylamino-Fluorene wurde ein wichtiger Unterschied zwischen den einfach- und zweifach-substituierten Derivaten aufgedeckt, der entscheidend für einen signifikanten Uncaging-Effizienzunterschied ist. Dabei stellt sich die Stabilität des symmetrisch-substituierten Fluorenyl-Kations als der wichtigste Faktor bezüglich der Uncaging-Quantenausbeuten heraus. Beide Schutzgruppen sind in der Lage photoinduziert eine AG freizusetzen, wobei der Reaktionsmechanismus über die kationische Spezies (DMA)(2)F + abläuft. Der Unterschied hierbei liegt in der Lebensdauer der beiden Kationen, die im Falle der symmetrischen PPG stark lösungsmittelabhängig ist und bis zu mehreren Stunden betragen kann, was bis dato das langlebigste Kation dieser Molekülklasse darstellt. Für die zukünftige Optimierung dieser PPG-Klasse ist die Erkenntnis über die Gründe für die Stabilität des Kations von großem Vorteil. Der stabilisierende Faktor ist zum einen die zweite Dimethylamino-Gruppe der symmetrischen Verbindung, welche durch die Erweiterung der Mesomerie zur besseren Verteilung der positiven Ladung im Molekül führt. Zum anderen spielt das Lösungsmittel eine entscheidende Rolle. Dabei bieten protische, polare Medien eine zusätzliche Stabilisierung, die notwendig für die Langlebigkeit des Kations ist. Die Lebensdauer des Kations war zudem durch eine zweite Bestrahlungswellenlänge kontrollierbar. Ausgehend vom Kation konnte eine reversible Nebenreaktion in protischen Lösungsmitteln identifiziert werden, die einen Austausch der AG durch das Lösungsmittel darstellt.
Zusätzlich konnte die kleine Stoffklasse der bisher bekannten Photobasen durch die Verbindung (DMA)2F-OH erweitert werden. Genauer betrachtet handelt es sich dabei um eine photoinduzierte Hydroxidfreisetzung, wodurch je nach eingesetzter Konzentration ein pH-Sprung von bis zu drei Einheiten erreicht werden konnte. Dabei stellt sich die Lebensdauer des pH-Sprungs als ein entscheidender Parameter für Photobasen dar, welcher sich für die hier untersuchte Verbindung aufgrund der besonderen Stabilität des entsprechenden Kations, im Vergleich zu einigen der bereits bekannten Verbindungen, als besonders langlebig herausgestellt hat. Ein weiterer Vorteil des Einsatzes von (DMA)2F-OH als Photobase ist die Möglichkeit den pH-Sprung durch zwei verschiedene Wellenlängen sowohl zeitlich als auch örtlich zu kontrollieren, indem die Verbindung zwischen den zwei Spezies (DMA)2F-OH und (DMA)2F + geschaltet werden kann.
Im Hinblick auf die Anwendungen von PPGs zur verbesserten zeitlichen und örtlichen Kontrolle biologischer Zielsysteme ist im Rahmen dieser Arbeit das Prinzip vom wellenlängenselektiven Uncaging zweier PPGs an einem Molekül (two-PPG-one-molecule, TPOM) etabliert worden. Das Zielmolekül war hier das Antibiotikum Puromycin, welches durch seine Fähigkeit an das Ribosom zu binden, die Proteinbiosynthese inhibieren kann. Dabei wurden zwei verschiedene PPGs gefunden, die sowohl aufeinander als auch auf das Biomolekül selbst abgestimmt sind. Im Ausgangszustand sind beide PPGs am Puromycin angebracht, wodurch es in seiner biologischen Wirkung inaktiv ist. Befindet sich das doppelt geschützte Puromycin in der ROI, so kann es durch die Bestrahlung mit einer bestimmten Wellenlänge infolge des ersten Uncaging-Schritts aktiviert werden. Da biologische Systeme nicht statisch sind, können aktivierte Moleküle stets von der gewünschten ROI nach außen gelangen, wodurch der Anspruch der räumlichen Kontrolle nicht erfüllt wird. In diesem Fall kann durch die TPOM-Umsetzung die zweite Bestrahlungswellenlänge auf den entsprechenden Bereich angewendet werden, wodurch das Uncaging der zweiten PPG initiiert und folglich das Puromycin deaktiviert wird. Des Weiteren konnte gezeigt werden, dass die Deaktivierungswellenlänge auch in der Lage ist beide PPGs zu entfernen, wodurch eine vollständige Inaktivierung des Puromycins außerhalb der ROI garantiert werden kann.
Ist die Proteinbiosynthese längerfristig blockiert, führt das schließlich zum Zelltod. Ein großes Anwendungsgebiet dieses Antibiotikums sind die Neurowissenschaften. Aufgrund der Tatsache, dass Puromycin keine Unterscheidung zwischen eukaryotischen und prokaryotischen Zellen macht, findet es keine Anwendung in der Medizin. Eine zeitliche und örtliche Kontrolle seiner Wirkung könnte den Anwendungsbereich dieses Antibiotikums evtl. ausweiten. Das wohl naheliegendste wäre der Einsatz bei Tumorzellen, deren Behandlung durch Zytostatika auf den gesamten Körper wirken und dadurch viele schwere Nebenwirkungen verursachen.
Wie bereits weiter oben beschrieben muss für jedes Biomolekül und das entsprechende Wirkzentrum die Auswahl des passenden PPG-Paares einzeln abgestimmt werden. Dennoch lässt sich anhand des hier etablierten Systems ein Konzept für die erfolgreiche Umsetzung zukünftiger TPOM-Systeme an anderen biomolekularen Wirkstoffen zusammenfassend formulieren.
* Der erste Schritt sollte die Betrachtung des Wirkzentrums des zu modifizierenden Biomoleküls sein: Welche funktionelle Gruppe bzw. Gruppen sind entscheidend für die Bindetasche oder –stelle? Dieser Bereich des Biomoleküls soll im Zuge des Uncagings entweder blockiert oder abgespalten werden. In der unmittelbaren Nähe muss die PPG1 angebracht werden.
* Bei der Wahl von PPG1 ist das wichtigste Kriterium, dass das Biomolekül mit enthaltener Schutzgruppe in seiner Wirkung unbeeinträchtigt bleibt. Dies schränkt die Auswahl beträchtlich ein. Eine mögliche Umsetzung wäre die Anbringung einer Nitro-Gruppe falls vorhanden an einen Benzolring, welcher sich im Fall eines großen Biomoleküls in der Nähe der wichtigen funktionellen Stelle befindet.
* Die zweite PPG (PPG2), deren photoinduzierte Abspaltung zur Aktivierung des Wirkstoffs führen soll, kann strukturell frei gewählt werden. Das Auswahlkriterium hierbei ist das Absorptionsspektrum. Hierbei sollte das Absorptionsmaximum rotverschoben zur PPG1 sein, um eine unerwünschte Abspaltung zu vermeiden. Außerdem darf keine signifikante Absorption von PPG2 bei der Uncaging-Wellenlänge von PPG1 vorhanden sein.
* Beide PPGs sollten eine ähnliche Uncaging-Quantenausbeute vorweisen, um im Deaktivierungsschritt der doppelt geschützten Verbindung durch das höher energetische Licht keine Bevorzugung einer einzelnen Schutzgruppe zu riskieren.
Anhand der erarbeiteten Herangehensweise können weitere Wirkstoffe oder Biomoleküle hin zu einer An- / Aus-Funktionalität modifiziert werden. Mit der Umsetzung des TPOM-Konzepts kann eine Verbesserung der örtlichen und zeitlichen Kontrolle der Aktivität eines Antibiotikums erreicht werden. Für die Anwendung in biologischer Umgebung ist diese präzische Kontrolle essentiell, um unerwünschte Nebenwirkungen angesundem Gewebe zu verhindern.
This article discusses the counterpart of interactive machine learning, i.e., human learning while being in the loop in a human-machine collaboration. For such cases we propose the use of a Contradiction Matrix to assess the overlap and the contradictions of human and machine predictions. We show in a small-scaled user study with experts in the area of pneumology (1) that machine-learning based systems can classify X-rays with respect to diseases with a meaningful accuracy, (2) humans partly use contradictions to reconsider their initial diagnosis, and (3) that this leads to a higher overlap between human and machine diagnoses at the end of the collaboration situation. We argue that disclosure of information on diagnosis uncertainty can be beneficial to make the human expert reconsider her or his initial assessment which may ultimately result in a deliberate agreement. In the light of the observations from our project, it becomes apparent that collaborative learning in such a human-in-the-loop scenario could lead to mutual benefits for both human learning and interactive machine learning. Bearing the differences in reasoning and learning processes of humans and intelligent systems in mind, we argue that interdisciplinary research teams have the best chances at tackling this undertaking and generating valuable insights.
We focus on the role of social media as a high-frequency, unfiltered mass information transmission channel and how its use for government communication affects the aggregate stock markets. To measure this effect, we concentrate on one of the most prominent Twitter users, the 45th President of the United States, Donald J. Trump. We analyze around 1,400 of his tweets related to the US economy and classify them by topic and textual sentiment using machine learning algorithms. We investigate whether the tweets contain relevant information for financial markets, i.e. whether they affect market returns, volatility, and trading volumes. Using high-frequency data, we find that Trump’s tweets are most often a reaction to pre-existing market trends and therefore do not provide material new information that would influence prices or trading. We show that past market information can help predict Trump’s decision to tweet about the economy.
Mitochondial NADH:ubiquinone oxidoreductase (complex I) the largest multiprotein enzyme of the respiratory chain, catalyses the transfer of two electrons from NADH to ubiquinone, coupled to the translocation of four protons across the membrane. In addition to the 14 strictly conserved central subunits it contains a variable number of accessory subunits. At present, the best characterized enzyme is complex I from bovine heart with a molecular mass of about 980 kDa and 32 accessory proteins. In this study, the subunit composition of mitochondrial complex I from the aerobic yeast Y. lipolytica has been analysed by a combination of proteomic and genomic approaches. The sequences of 37 complex I subunits were identified. The sum of their individual molecular masses (about 930 kDa) was consistent with the native molecular weight of approximately 900 kDa for Y. lipolytica complex I obtained by BN-PAGE. A genomic analysis with Y. lipolytica and other eukaryotic databases to search for homologues of complex I subunits revealed 31 conserved proteins among the examined species. A novel protein named “X” was found in purified Y. lipolytica complex I by MALDI-MS. This protein exhibits homology to the thiosulfate sulfurtransferase enzyme referred to as rhodanese. The finding of a rhodanese-like protein in isolated complex I of Y. lipolytica allows to assume a special regulatory mechanism of complex I activity through control of the status of its iron-sulfur clusters. The second part of this study was aimed at investigating the possible role of one of these extra subunits, 39 kDa (NUEM) subunit which is related to the SDRs-enzyme family. The members of this family function in different redox and isomerization reactions and contain a conserved NAD(P)H-binding site. It was proposed that the 39 kDa subunit may be involved in a biosynthetic pathway, but the role of this subunit in complex I is unknown. In contrast to the situation in N. crassa, deletion of the 39 kDa encoding gene in Y. lipolytica led to the absence of fully assembled complex I. This result might indicate a different pathway of complex I assembly in both organisms. Several site-directed mutations were generated in the nucleotide binding motif. These had either no effect on enzyme activity and NADPH binding, or prevented complex I assembly. Mutations of arginine-65 that is located at the end of the second b-strand and responsible for selective interaction with the 2’-phosphate group of NADPH retained complex I activity in mitochondrial membranes but the affinity for the cofactor was markedly decreased. Purification of complex I from mutants resulted in decrease or loss of ubiquinone reductase activity. It is very likely that replacement of R65 not only led to a decrease in affinity for NADPH but also caused instability of the enzyme due to steric changes in the 39 kDa subunit. These data indicate that NADPH bound to the 39 kDa subunit (NUEM) is not essential for complex I activity, but probably involved in complex I assembly in Y. lipolytica.
Índice Gramática Lição Adjectivos 4.1 Demonstrativos 12.1 Interrogativos 13.1 Números cardinais 4.2 Possessivo nominal 11.1 Possessivo pronominal 9.2 Pronomes pessoais 1.2 Substantivo: classes 1-10 2.1 Substantivos: classes 1-18 6.1 Verbo: infinitivo 1.1 Verbo: infinitivo negativo 3.1 Verbo: optativo 8.2 Verbo: passado recente e remoto 14.1 Verbo: prefixo do objecto 8.1 Verbo: prefixo do sujeito 1.3 Verbo: prefixo do sujeito (classes 3-14) 7.1 Verbo: presente contínuo 2.2 Verbo: presente contínuo negativo 3.3 Verbo: presente do indicativo 1.4 Verbo: presente negativo 3.2
Übermäßige Gewaltanwendungen durch Polizist:innen in Deutschland sind bislang nur in Ansätzen untersucht. Das Buch liefert umfassende wissenschaftliche Befunde zu einschlägigen Situationen und ihrer strafrechtlichen Aufarbeitung. Auf Basis einer Betroffenenbefragung mit über 3.300 Teilnehmenden und über 60 qualitativen Interviews stellen sich die Fälle als komplexe Interaktionsgeschehen dar, bei deren Aufarbeitung eine besondere Definitionsmacht der Polizei sichtbar wird.
Das Forschungsprojekt KviAPol (Körperverletzung im Amt durch Polizeibeamte und -beamtinnen) untersucht polizeiliche Gewaltanwendungen, die aus Sicht der Betroffenen rechtswidrig waren, mittels quantitativer Online-Befragung sowie die polizeiliche, justizielle und zivilgesellschaftliche Perspektive auf rechtswidrige Polizeigewalt und deren Aufarbeitung in Deutschland mittels qualitativer Interviews. Zum Team gehören die Wissenschaftlichen Mitarbeiterinnen Laila Abdul-Rahman, Hannah Espín Grau und Luise Klaus sowie Prof. Dr. Tobias Singelnstein, der die Projektleitung innehat.
In relativistic heavy-ion collisions, a global spin polarization, PH, of Λ and Λ¯ hyperons along the direction of the system angular momentum was discovered and measured across a broad range of collision energies and demonstrated a trend of increasing PH with decreasing sNN−−−√. A splitting between Λ and Λ¯ polarization may be possible due to their different magnetic moments in a late-stage magnetic field sustained by the quark-gluon plasma which is formed in the collision. The results presented in this study find no significant splitting at the collision energies of sNN−−−√=19.6 and 27 GeV in the RHIC Beam Energy Scan Phase II using the STAR detector, with an upper limit of PΛ¯−PΛ<0.24% and PΛ¯−PΛ<0.35%, respectively, at a 95% confidence level. We derive an upper limit on the naïve extraction of the late-stage magnetic field of B<9.4⋅1012 T and B<1.4⋅1013 T at sNN−−−√=19.6 and 27 GeV, respectively, although more thorough derivations are needed. Differential measurements of PH were performed with respect to collision centrality, transverse momentum, and rapidity. With our current acceptance of |y|<1 and uncertainties, we observe no dependence on transverse momentum and rapidity in this analysis. These results challenge multiple existing model calculations following a variety of different assumptions which have each predicted a strong dependence on rapidity in this collision-energy range.
In relativistic heavy-ion collisions, a global spin polarization, PH, of Λ and Λ¯ hyperons along the direction of the system angular momentum was discovered and measured across a broad range of collision energies and demonstrated a trend of increasing PH with decreasing sNN−−−√. A splitting between Λ and Λ¯ polarization may be possible due to their different magnetic moments in a late-stage magnetic field sustained by the quark-gluon plasma which is formed in the collision. The results presented in this study find no significant splitting at the collision energies of sNN−−−√=19.6 and 27 GeV in the RHIC Beam Energy Scan Phase II using the STAR detector, with an upper limit of PΛ¯−PΛ<0.24% and PΛ¯−PΛ<0.35%, respectively, at a 95% confidence level. We derive an upper limit on the naïve extraction of the late-stage magnetic field of B<9.4⋅1012 T and B<1.4⋅1013 T at sNN−−−√=19.6 and 27 GeV, respectively, although more thorough derivations are needed. Differential measurements of PH were performed with respect to collision centrality, transverse momentum, and rapidity. With our current acceptance of |y|<1 and uncertainties, we observe no dependence on transverse momentum and rapidity in this analysis. These results challenge multiple existing model calculations following a variety of different assumptions which have each predicted a strong dependence on rapidity in this collision-energy range.
In relativistic heavy-ion collisions, a global spin polarization, PH, of Λ and Λ¯ hyperons along the direction of the system angular momentum was discovered and measured across a broad range of collision energies and demonstrated a trend of increasing PH with decreasing sNN−−−√. A splitting between Λ and Λ¯ polarization may be possible due to their different magnetic moments in a late-stage magnetic field sustained by the quark-gluon plasma which is formed in the collision. The results presented in this study find no significant splitting at the collision energies of sNN−−−√=19.6 and 27 GeV in the RHIC Beam Energy Scan Phase II using the STAR detector, with an upper limit of PΛ¯−PΛ<0.24% and PΛ¯−PΛ<0.35%, respectively, at a 95% confidence level. We derive an upper limit on the naïve extraction of the late-stage magnetic field of B<9.4⋅1012 T and B<1.4⋅1013 T at sNN−−−√=19.6 and 27 GeV, respectively, although more thorough derivations are needed. Differential measurements of PH were performed with respect to collision centrality, transverse momentum, and rapidity. With our current acceptance of |y|<1 and uncertainties, we observe no dependence on transverse momentum and rapidity in this analysis. These results challenge multiple existing model calculations following a variety of different assumptions which have each predicted a strong dependence on rapidity in this collision-energy range.
Elliptic flow of heavy-flavor decay electrons in Au+Au collisions at √sNN = 27 and 54.4 GeV at RHIC
(2023)
We report on new measurements of elliptic flow (v2) of electrons from heavy-flavor hadron decays at mid-rapidity (|y|<0.8) in Au+Au collisions at sNN−−−√ = 27 and 54.4 GeV from the STAR experiment. Heavy-flavor decay electrons (eHF) in Au+Au collisions at sNN−−−√ = 54.4 GeV exhibit a non-zero v2 in the transverse momentum (pT) region of pT< 2 GeV/c with the magnitude comparable to that at sNN−−−√=200 GeV. The measured eHF v2 at 54.4 GeV is also consistent with the expectation of their parent charm hadron v2 following number-of-constituent-quark scaling as other light and strange flavor hadrons at this energy. These suggest that charm quarks gain significant collectivity through the evolution of the QCD medium and may reach local thermal equilibrium in Au+Au collisions at sNN−−−√=54.4 GeV. The measured eHF v2 in Au+Au collisions at sNN−−−√= 27 GeV is consistent with zero within large uncertainties. The energy dependence of v2 for different flavor particles (π,ϕ,D0/eHF) shows an indication of quark mass hierarchy in reaching thermalization in high-energy nuclear collisions.
Density fluctuations near the QCD critical point can be probed via an intermittency analysis in relativistic heavy-ion collisions. We report the first measurement of intermittency in Au+Au collisions at √sNN = 7.7-200 GeV measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The scaled factorial moments of identified charged hadrons are analyzed at mid-rapidity and within the transverse momentum phase space. We observe a power-law behavior of scaled factorial moments in Au+Au collisions and a decrease in the extracted scaling exponent (ν) from peripheral to central collisions. The ν is consistent with a constant for different collisions energies in the mid-central (10-40%) collisions. Moreover, the ν in the 0-5% most central Au+Au collisions exhibits a non-monotonic energy dependence that reaches a minimum around √sNN = 27 GeV. The physics implications on the QCD phase structure are discussed.
Elliptic flow of heavy-flavor decay electrons in Au+Au collisions at √sNN = 27 and 54.4 GeV at RHIC
(2023)
We report on new measurements of elliptic flow (v2) of electrons from heavy-flavor hadron decays at mid-rapidity (|y|<0.8) in Au+Au collisions at sNN−−−√ = 27 and 54.4 GeV from the STAR experiment. Heavy-flavor decay electrons (eHF) in Au+Au collisions at sNN−−−√ = 54.4 GeV exhibit a non-zero v2 in the transverse momentum (pT) region of pT< 2 GeV/c with the magnitude comparable to that at sNN−−−√=200 GeV. The measured eHF v2 at 54.4 GeV is also consistent with the expectation of their parent charm hadron v2 following number-of-constituent-quark scaling as other light and strange flavor hadrons at this energy. These suggest that charm quarks gain significant collectivity through the evolution of the QCD medium and may reach local thermal equilibrium in Au+Au collisions at sNN−−−√=54.4 GeV. The measured eHF v2 in Au+Au collisions at sNN−−−√= 27 GeV is consistent with zero within large uncertainties. The energy dependence of v2 for different flavor particles (π,ϕ,D0/eHF) shows an indication of quark mass hierarchy in reaching thermalization in high-energy nuclear collisions.
We report a new measurement of the production of electrons from open heavy-flavor hadron decays (HFEs) at mid-rapidity (|y|< 0.7) in Au+Au collisions at sNN−−−√=200 GeV. Invariant yields of HFEs are measured for the transverse momentum range of 3.5<pT<9 GeV/c in various configurations of the collision geometry. The HFE yields in head-on Au+Au collisions are suppressed by approximately a factor of 2 compared to that in p+p collisions scaled by the average number of binary collisions, indicating strong interactions between heavy quarks and the hot and dense medium created in heavy-ion collisions. Comparison of these results with models provides additional tests of theoretical calculations of heavy quark energy loss in the quark-gluon plasma.
We report a new measurement of the production of electrons from open heavy-flavor hadron decays (HFEs) at mid-rapidity (|y|< 0.7) in Au+Au collisions at sNN−−−√=200 GeV. Invariant yields of HFEs are measured for the transverse momentum range of 3.5<pT<9 GeV/c in various configurations of the collision geometry. The HFE yields in head-on Au+Au collisions are suppressed by approximately a factor of 2 compared to that in p+p collisions scaled by the average number of binary collisions, indicating strong interactions between heavy quarks and the hot and dense medium created in heavy-ion collisions. Comparison of these results with models provides additional tests of theoretical calculations of heavy quark energy loss in the quark-gluon plasma.
We report a new measurement of the production of electrons from open heavy-flavor hadron decays (HFEs) at mid-rapidity (|y| < 0.7) in Au+Au collisions at √sNN = 200 GeV. Invariant yields of HFEs are measured for the transverse momentum range of 3.5 < pT < 9 GeV/c in various configurations of the collision geometry. The HFE yields in head-on Au+Au collisions are suppressed by approximately a factor of 2 compared to that in p + p collisions scaled by the average number of binary collisions, indicating strong interactions between heavy quarks and the hot and dense medium created in heavy-ion collisions. Comparison of these results with models provides additional tests of theoretical calculations of heavy quark energy loss in the quark-gluon plasma.
Density fluctuations near the QCD critical point can be probed via an intermittency analysis in relativistic heavy-ion collisions. We report the first measurement of intermittency in Au+Au collisions at sNN−−−√ = 7.7-200 GeV measured by the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The scaled factorial moments of identified charged hadrons are analyzed at mid-rapidity and within the transverse momentum phase space. We observe a power-law behavior of scaled factorial moments in Au+Au collisions and a decrease in the extracted scaling exponent (ν) from peripheral to central collisions. The ν is consistent with a constant for different collisions energies in the mid-central (10-40\%) collisions. Moreover, the ν in the 0-5\% most central Au+Au collisions exhibits a non-monotonic energy dependence that reaches a possible minimum around sNN−−−√ = 27 GeV. The physics implications on the QCD phase structure are discussed.
The longitudinal and transverse spin transfers to Λ (Λ¯¯¯¯) hyperons in polarized proton-proton collisions are expected to be sensitive to the helicity and transversity distributions, respectively, of (anti-)strange quarks in the proton, and to the corresponding polarized fragmentation functions. We report improved measurements of the longitudinal spin transfer coefficient, DLL, and the transverse spin transfer coefficient, DTT, to Λ and Λ¯¯¯¯ in polarized proton-proton collisions at s√ = 200 GeV by the STAR experiment at RHIC. The data set includes longitudinally polarized proton-proton collisions with an integrated luminosity of 52 pb−1, and transversely polarized proton-proton collisions with a similar integrated luminosity. Both data sets have about twice the statistics of previous results and cover a kinematic range of |ηΛ(Λ¯¯¯¯)| < 1.2 and transverse momentum pT,Λ(Λ¯¯¯¯) up to 8 GeV/c. We also report the first measurements of the hyperon spin transfer coefficients DLL and DTT as a function of the fractional jet momentum z carried by the hyperon, which can provide more direct constraints on the
The longitudinal and transverse spin transfers to Λ (Λ¯¯¯¯) hyperons in polarized proton-proton collisions are expected to be sensitive to the helicity and transversity distributions, respectively, of (anti-)strange quarks in the proton, and to the corresponding polarized fragmentation functions. We report improved measurements of the longitudinal spin transfer coefficient, DLL, and the transverse spin transfer coefficient, DTT, to Λ and Λ¯¯¯¯ in polarized proton-proton collisions at s√ = 200 GeV by the STAR experiment at RHIC. The data set includes longitudinally polarized proton-proton collisions with an integrated luminosity of 52 pb−1, and transversely polarized proton-proton collisions with a similar integrated luminosity. Both data sets have about twice the statistics of previous results and cover a kinematic range of |ηΛ(Λ¯¯¯¯)| < 1.2 and transverse momentum pT,Λ(Λ¯¯¯¯) up to 8 GeV/c. We also report the first measurements of the hyperon spin transfer coefficients DLL and DTT as a function of the fractional jet momentum z carried by the hyperon, which can provide more direct constraints on the polarized fragmentation functions.
The differential cross section for 𝑍0 production, measured as a function of the boson’s transverse momentum (𝑝T), provides important constraints on the evolution of the transverse momentum dependent parton distribution functions (TMDs). The transverse single spin asymmetry (TSSA) of the 𝑍0 is sensitive to one of the polarized TMDs, the Sivers function, which is predicted to have the opposite sign in 𝑝 + 𝑝 → 𝑊 ∕𝑍 + 𝑋 from that which enters in semi-inclusive deep inelastic scattering. In this Letter, the STAR Collaboration reports the first measurement of the 𝑍0∕𝛾∗ differential cross section as a function of its 𝑝T in 𝑝+𝑝 collisions at a center-of-mass energy of 510 GeV, together with the 𝑍0∕𝛾∗ total cross section. We also report the measurement of 𝑍0∕𝛾∗ TSSA in transversely polarized 𝑝+𝑝 collisions at 510 GeV.
We report results on an elastic cross section measurement in proton–proton collisions at a center-of-mass energy √𝑠 = 510 GeV, obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section is measured in the four-momentum transfer squared range 0.23 ≤ −𝑡 ≤ 0.67 GeV2. This is the only measurement of the proton-proton elastic cross section in this 𝑡 range for collision energies above the Intersecting Storage Rings (ISR) and below the Large Hadron Collider (LHC) colliders. We find that a constant slope 𝐵 does not fit the data in the aforementioned 𝑡 range, and we obtain a much better fit using a second-order polynomial for 𝐵(𝑡). This is the first measurement below the LHC energies for which the non-constant behavior 𝐵(𝑡) is observed. The 𝑡 dependence of 𝐵 is also determined using six subintervals of 𝑡 in the STAR measured 𝑡 range, and is in good agreement with the phenomenological models. The measured elastic differential cross section d𝜎∕dt agrees well with the results obtained at √𝑠 = 540 GeV for proton–antiproton collisions by the UA4 experiment. We also determine that the integrated elastic cross section within the STAR 𝑡-range is 𝜎f id el = 462.1 ± 0.9(stat.) ± 1.1(syst.) ± 11.6(scale) 𝜇b.
We report the first measurements of cumulants, up to 4𝑡ℎ order, of deuteron number distributions and protondeuteron correlations in Au+Au collisions recorded by the STAR experiment in phase-I of Beam Energy Scan (BES) program at the Relativistic Heavy Ion Collider. Deuteron cumulants, their ratios, and proton-deuteron mixed cumulants are presented for different collision centralities covering a range of center-of-mass energy per nucleon pair √𝑠NN = 7.7 to 200 GeV. It is found that the cumulant ratios at lower collision energies favor a canonical ensemble over a grand canonical ensemble in thermal models. An anti-correlation between proton and deuteron multiplicity is observed across all collision energies and centralities, consistent with the expectation from global baryon number conservation. The UrQMD model coupled with a phase-space coalescence mechanism qualitatively reproduces the collision-energy dependence of cumulant ratios and proton-deuteron correlations.
We report results on an elastic cross section measurement in proton-proton collisions at a center-of-mass energy s√=510 GeV, obtained with the Roman Pot setup of the STAR experiment at the Relativistic Heavy Ion Collider (RHIC). The elastic differential cross section is measured in the four-momentum transfer squared range 0.23≤−t≤0.67 GeV2. We find that a constant slope B does not fit the data in the aforementioned t range, and we obtain a much better fit using a second-order polynomial for B(t). The t dependence of B is determined using six subintervals of t in the STAR measured t range, and is in good agreement with the phenomenological models. The measured elastic differential cross section dσ/dt agrees well with the results obtained at s√=546 GeV for proton--antiproton collisions by the UA4 experiment. We also determine that the integrated elastic cross section within the STAR t-range is σfidel=462.1±0.9(stat.)±1.1(syst.)±11.6(scale) μb.
We report the first measurements of cumulants, up to 4th order, of deuteron number distributions and proton-deuteron correlations in Au+Au collisions recorded by the STAR experiment in phase-I of Beam Energy Scan (BES) program at the Relativistic Heavy Ion Collider. Deuteron cumulants, their ratios, and proton-deuteron mixed cumulants are presented for different collision centralities covering a range of center-of-mass energy per nucleon pair sNN−−−−√~=~7.7 to 200~GeV. It is found that the cumulant ratios at lower collision energies favor a canonical ensemble over a grand canonical ensemble in thermal models. An anti-correlation between proton and deuteron multiplicity is observed across all collision energies and centralities, consistent with the expectation from global baryon number conservation. The UrQMD model coupled with a phase-space coalescence mechanism qualitatively reproduces the collision-energy dependence of cumulant ratios and proton-deuteron correlations.
We measure triangular flow relative to the reaction plane at 3 GeV center-of-mass energy in Au+Au collisions at the BNL Relativistic Heavy Ion Collider. A significant v3 signal for protons is observed, which increases for higher rapidity, higher transverse momentum, and more peripheral collisions. The triangular flow is essentially rapidity-odd with a slope at mid-rapidity, dv3/dy|(y=0), opposite in sign compared to the slope for directed flow. No significant v3 signal is observed for charged pions and kaons. Comparisons with models suggest that a mean field potential is required to describe these results, and that the triangular shape of the participant nucleons is the result of stopping and nuclear geometry.
Jet-hadron correlations with respect to the event plane in √sNN = 200 GeV Au+Au collisions in STAR
(2024)
Angular distributions of charged particles relative to jet axes are studied in sNN−−−√ = 200 GeV Au+Au collisions as a function of the jet orientation with respect to the event plane. This differential study tests the expected path-length dependence of energy loss experienced by a hard-scattered parton as it traverses the hot and dense medium formed in heavy-ion collisions. A second-order event plane is used in the analysis as an experimental estimate of the reaction plane formed by the collision impact parameter and the beam direction. Charged-particle jets with 15<pT,jet< 20 and 20<pT,jet< 40 GeV/c were reconstructed with the anti-kT algorithm with radius parameter setting of (R=0.4) in the 20-50\% centrality bin to maximize the initial-state eccentricity of the interaction region. The reaction plane fit method is implemented to remove the flow-modulated background with better precision than prior methods. Yields and widths of jet-associated charged-hadron distributions are extracted in three angular bins between the jet axis and the event plane. The event-plane (EP) dependence is further quantified by ratios of the associated yields in different EP bins. No dependence on orientation of the jet axis with respect to the event plane is seen within the uncertainties in the kinematic regime studied. This finding is consistent with a similar experimental observation by ALICE in sNN−−−√ = 2.76 TeV Pb+Pb collision data.
Jet-hadron correlations with respect to the event plane in √sNN = 200 GeV Au+Au collisions in STAR
(2024)
Angular distributions of charged particles relative to jet axes are studied in sNN−−−√ = 200 GeV Au+Au collisions as a function of the jet orientation with respect to the event plane. This differential study tests the expected path-length dependence of energy loss experienced by a hard-scattered parton as it traverses the hot and dense medium formed in heavy-ion collisions. A second-order event plane is used in the analysis as an experimental estimate of the reaction plane formed by the collision impact parameter and the beam direction. Charged-particle jets with 15<pT,jet< 20 and 20<pT,jet< 40 GeV/c were reconstructed with the anti-kT algorithm with radius parameter setting of (R=0.4) in the 20-50\% centrality bin to maximize the initial-state eccentricity of the interaction region. The reaction plane fit method is implemented to remove the flow-modulated background with better precision than prior methods. Yields and widths of jet-associated charged-hadron distributions are extracted in three angular bins between the jet axis and the event plane. The event-plane (EP) dependence is further quantified by ratios of the associated yields in different EP bins. No dependence on orientation of the jet axis with respect to the event plane is seen within the uncertainties in the kinematic regime studied. This finding is consistent with a similar experimental observation by ALICE in sNN−−−√ = 2.76 TeV Pb+Pb collision data.
The polarization of Λ and Λ¯ hyperons along the beam direction has been measured relative to the second and third harmonic event planes in isobar Ru+Ru and Zr+Zr collisions at √sNN = 200 GeV. This is the first experimental evidence of the hyperon polarization by the triangular flow originating from the initial density fluctuations. The amplitudes of the sine modulation for the second and third harmonic results are comparable in magnitude, increase from central to peripheral collisions, and show a mild pT dependence. The azimuthal angle dependence of the polarization follows the vorticity pattern expected due to elliptic and triangular anisotropic flow, and qualitatively disagree with most hydrodynamic model calculations based on thermal vorticity and shear induced contributions. The model results based on one of existing implementations of the shear contribution lead to a correct azimuthal angle dependence, but predict centrality and pT dependence that still disagree with experimental measurements. Thus, our results provide stringent constraints on the thermal vorticity and shear-induced contributions to hyperon polarization. Comparison to previous measurements at RHIC and the LHC for the second-order harmonic results shows little dependence on the collision system size and collision energy.
The elliptic (v2) and triangular (v3) azimuthal anisotropy coefficients in central 3He+Au, d+Au, and p+Au collisions at sNN−−−√ = 200 GeV are measured as a function of transverse momentum (pT) at mid-rapidity (|η|<0.9), via the azimuthal angular correlation between two particles both at |η|<0.9. While the v2(pT) values depend on the colliding systems, the v3(pT) values are system-independent within the uncertainties, suggesting an influence on eccentricity from sub-nucleonic fluctuations in these small-sized systems. These results also provide stringent constraints for the hydrodynamic modeling of these systems.
The relevance of the work and the influence of Franz Rosenzweig, a German Jewish philosopher of the beginning of the last century; are still to get the appreciation they deserve. Rosenzweig was the author of one of the greatest – and less read – books of the 20th century, "The Star of Redemption", where he develops his philosophical system mainly on basis of theological categories. To the "monologue of the I" of mainstream philosophy, Rosenzweig opposes a "new thinking", of existential character, which values orality and the "other", and where language substitutes reason as a tool for thought. In it one can find some correspondences with the thought of Walter Benjamin. This "new thinking", also, strongly influenced Emmanuel Levinas and nowadays bears its fruits within "linguistic turn" philosophy and theology, and post-modern Jewish thought. This philosophy found in Rosenzweig's work in translation one of its main practical applications. To translate was for Rosenzweig a necessity, emanating from an ethics constituted as "first philosophy". This article examines some aspects of Rosenzweig's writings from where his "philosophy of translation" is made explicit.
Death and the King's Grey Hair and Other Plays is a collection of three plays, 'Death and the King's Grey Hair, ' 'Truce with the Devil, ' and 'Fringe Benefits, ' which are all experimental plays from the early period of the writing career of Denja Abdullahi, who is presently renowned as a poet of populist expressions. 'Death and the King's Grey Hair' examines the use and misuse of absolute power based on an ancient Jukun myth of young kings and short reigns. 'Truce with the Devil' is a satire on the later abandonment of the creed of Marxism by its adherents, a kind of mockery of turncoat revolutionaries in the grip of practical social realities. 'Fringe Benefits', a radio play, is an expose of the happening in Nigeria's ivory towers, seen from the eyes of a participant-observer.
Background and Aims: Fecal biomarkers are important non-invasive markers monitoring disease activity in inflammatory bowel disease (IBD). We compared the significance of fecal eosinophil cationic protein (fECP) and fecal calprotectin (fCal).
Methods: fECP and fCal were measured in patients with Crohn's disease (CD, n = 97), ulcerative colitis (UC, n = 53), Clostridioides difficile infection (CDI, n = 9), primary food allergy (PFA, n = 11), pollen-associated food allergy (n = 25) and non-inflammatory controls (n = 78). Results were correlated with clinical and endoscopic IBD activity scores.
Results: fECP was significantly elevated in CD, UC, CDI and PFA compared to controls. fCal was significantly increased in CD, UC and CDI. fECP had lower diagnostic accuracy than fCal (area under the curve (AUC) = 0.88) in differentiating between endoscopically active and inactive patients with IBD (AUC = 0.77, ROC analysis). In contrast to fCal, fECP correlated negatively with age and levels were also elevated in clinically and endoscopically inactive patients with IBD <45 years (endoscopically inactive IBD vs controls; AUC for fECP = 0.86; AUC for fCal = 0.62). However, in those patients with low inflammatory activity (fCal <250 mg/kg), high fECP indicated the need for treatment modification or surgery (fECP <200 µg/kg = 22%; 200–600 µg/kg = 44%; >600 µg/kg = 82%) at month 48 of follow-up.
Conclusions: fECP is a diagnostic and prognostic marker in young patients with IBD in remission.
Leaving aside elliptical coordinations, it is striking that no agreement has been reached on the structure of basic coordinate constructions. We propose that:
- coordinate constructions are structurally asymmetric: the conjunction makes a subconstituent with one of the conjuncts.
- such constituents can have several functions: coordinate daughter, adjunct daughter or main clause.
In order to show that some conjuncts should be analysed as adjuncts, we focus on asymmetric cases of coordination, in which the order of the conjuncts cannot be reversed, taking examples from French, Welsh and Korean. We present an HPSG analysis which treats the coordinating conjunctions as weak heads, with lexical subtypes, and coordinate phrases as multi-headed constructions, with different subtypes.
Of all French functional elements, the form de has without question the widest variety of uses, and presents the greatest challenge for linguistic description and analysis. Historically a preposition, it still has a number of prepositional uses in modern French, but in many contexts it calls for an altogether different treatment. We begin by outlining a general distinction between oblique and non-oblique uses of de. We then develop a detailed account of constructions where de combines with an N'. We provide a unitary analysis of de in three constructions (quantifier extraction, "quantification at a distance", and negative contexts) which have been not been considered to be related in previous accounts.
In French, Italian, and Romanian, forms inherited from the Latin paradigm 'esse' are used for the copula, the passive auxiliary and tense or perfective auxiliaries. We show that the copula and the passive auxiliary should be identified, while the tense or perfective auxiliaries are different lexemes. Moreover, the copula has the same description across all the Romance languages. While they all are argument inheritance verbs, the copula and the tense or perfective auxiliaries differ with respect to their complement structure: (i) the second only have one complement structure (the complement participle is complement unsaturated), the copula has two complement structures (the predicate is either complement saturated or unsaturated); (ii) French and Italian tense auxiliaries are the head of a flat VP, where the participle is sister to its subcategorized complements, the Romanian perfective auxiliary is the head of a verbal complex; (iii) when the complement predicate is unsaturated, the Romance copula is the head of a flat VP.
Two consequences of the analysis are worth mentioning. First, the copula (and the passive auxiliary) should not be taken into account when stating the environments for auxiliary selection in French and Italian. Second, argument inheritance and complement structure are different phenomena, and argue in favor of theories which systematically distinguish between valence features and constituent structures.