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- heavy-ion collisions (18)
- household finance (18)
- mTOR (18)
- memory (18)
- mortality (18)
- proliferation (18)
- tumor microenvironment (18)
- water-filtered infrared-A (wIRA) (18)
- ALICE (17)
- Afrotropical Region (17)
- Aging (17)
- Alltag (17)
- Anthropozän (17)
- Arbeiterinnenbewegung (17)
- Auchenorrhyncha (17)
- Autobiografische Literatur (17)
- Börsenzulassung (17)
- Cambodia (17)
- Comicroman (17)
- Computer (17)
- Emanzipation (17)
- Escola de Frankfurt (17)
- Essay (17)
- Etymologie (17)
- Fagus sylvatica (17)
- Fehler (17)
- Filmographie (17)
- Florida (17)
- Französische Revolution (17)
- Freie Gewerkschaft (17)
- Frühe Neuzeit (17)
- Frühneuhochdeutsch (17)
- Grillparzer, Franz (17)
- Gutzkow, Karl (17)
- Horrorfilm (17)
- Industriearbeiterin (17)
- Islamismus (17)
- Judentum (17)
- Kajkavisch (17)
- Kapitalmarktrecht (17)
- Marx, Karl (17)
- Methode (17)
- Mundart (17)
- Natur <Motiv> (17)
- Oesterle, Günter (17)
- Photographie (17)
- Presse (17)
- Professionalisierung (17)
- Rezensionen (17)
- Schriftstellerin (17)
- Schule (17)
- Shakespeare, William (17)
- Social System (17)
- Spieltheorie (17)
- Sprachkritik (17)
- Sprachpolitik (17)
- Sprachverstehen (17)
- Stilistik (17)
- Surgery (17)
- Synergie (17)
- Tabu (17)
- Teoria crítica (17)
- Textverstehen (17)
- Topikalisierung (17)
- Verlag (17)
- Vielfalt (17)
- Wertpapieremission (17)
- Wettbewerb (17)
- Wirklichkeit (17)
- climate (17)
- endothelial cells (17)
- gene therapy (17)
- glioma (17)
- host plants (17)
- new genera (17)
- parasitoid (17)
- phenology (17)
- schizophrenia (17)
- stroke (17)
- treatment (17)
- vegetation classification (17)
- Adverb (16)
- Angiogenesis (16)
- Anthologie (16)
- Asia (16)
- Biogeography (16)
- Biomarkers (16)
- Caribbean (16)
- CiNyungwe (16)
- Datenschutz (16)
- Distribution (16)
- EBA (16)
- Euro (16)
- Finanzwirtschaft (16)
- Fiscal Policy (16)
- Gene expression (16)
- Genossenschaftsbewegung (16)
- Geschichte 1800-1900 (16)
- Gesprochene Sprache (16)
- Gewerkverein der Heimarbeiterinnen Deutschlands für Kleider- und Wäschekonfektion und verwandte Berufe (1900-) (16)
- Gleichberechtigung (16)
- Grammatikalisation (16)
- Grammatiktheorie (16)
- Grass, Günter (16)
- Hausarbeit (16)
- Hegel, Georg Wilhelm Friedrich (16)
- Herrschaft (16)
- Industriearbeit (16)
- Infektionsabwehr (16)
- Infrarot (16)
- Journalismus (16)
- Kasus (16)
- Kollokation (16)
- Koti (16)
- Kreditwesen (16)
- Krim (16)
- Magnetic resonance imaging (16)
- Memory (16)
- Migration <Motiv> (16)
- Modellierung (16)
- Mähren (16)
- Müller, Heiner (16)
- Nachlass (16)
- Nibelungenlied (16)
- Nordrhein-Westfalen (16)
- Nyungwe (16)
- Open Access (16)
- Outcome (16)
- Preußen (16)
- Prostitution (16)
- Pädagogik (16)
- QCD (16)
- Selbstdarstellung (16)
- Sicherheit (16)
- Sicherheitspolitik (16)
- Sprachstatistik (16)
- Stadt <Motiv> (16)
- Synthesis (16)
- Systematics (16)
- Terminologie (16)
- Transparenz (16)
- Transylvanian Saxons (16)
- Ungarisch (16)
- Unternehmen (16)
- Vergleich (16)
- Wahlkampf (16)
- X-ray crystallography (16)
- Zeitung (16)
- asset pricing (16)
- cryptic species (16)
- culture (16)
- financial stability (16)
- gene expression (16)
- hippocampus (16)
- inflation (16)
- key to species (16)
- miRNA (16)
- multiple sclerosis (16)
- ordination (16)
- oxidative stress (16)
- populism (16)
- proteomics (16)
- terrorism (16)
- uncertainty (16)
- word order (16)
- Ägypten (16)
- Alphabetisierung (15)
- Altgermanistik (15)
- Arbeitslosigkeit (15)
- Australia (15)
- Außenpolitik (15)
- Bildnis (15)
- Börne, Ludwig (15)
- Carabidae (15)
- Children (15)
- Chuwabu (15)
- Cirrhosis (15)
- Contagion (15)
- Culture (15)
- Das Ganze (15)
- Demography (15)
- EKoti (15)
- Echuwabo (15)
- Erzählforschung (15)
- Finanzierung (15)
- France (15)
- Fußball (15)
- Gefühl <Motiv> (15)
- Heavy-ion collisions (15)
- Historismus (15)
- Hochschuldidaktik (15)
- Hochschule (15)
- Hymenoptera (15)
- ISIS (15)
- Ideologie (15)
- Immunology (15)
- Indogermanische Sprachen (15)
- Interkulturelles Lernen (15)
- Interrogativsatz (15)
- Jean Paul (15)
- Klima (15)
- Konsumgenossenschaft (15)
- Korruption (15)
- Kritische Theorie (15)
- Kulturanthropologie (15)
- Kulturwissenschaft (15)
- Kulturwissenschaftliche Bibliothek Warburg (15)
- Landarbeiterin (15)
- Lehrbuch (15)
- Lepidoptera (15)
- Literaturgeschichte (15)
- Machine Learning (15)
- Macht (15)
- Maschinelle Übersetzung (15)
- Mimesis (15)
- Mitgliederwerbung (15)
- Morphosyntax (15)
- Muttersprache (15)
- Nachhaltigkeit (15)
- Nachkriegszeit (15)
- Nationalbewusstsein (15)
- Obama (15)
- Palaearctic (15)
- Pension Insurance (15)
- Politische Verfolgung (15)
- Prophetie (15)
- Protest (15)
- QGP (15)
- Quantitative Easing (15)
- Sarawak (15)
- Simulation (15)
- Solvency II (15)
- South Africa (15)
- Sprechakt (15)
- Twitter (15)
- Wahlagitation (SPD) (15)
- Warburg, Aby Moritz (15)
- Westafrika (15)
- Wiederholung (15)
- Wikileaks (15)
- Wolf, Christa (15)
- cytokines (15)
- e +-e − Experiments (15)
- human rights (15)
- introduced species (15)
- lung cancer (15)
- mass spectrometry (15)
- obesity (15)
- parasitoids (15)
- planthopper (15)
- radical prostatectomy (15)
- recognition (15)
- reduction of pain (15)
- review (15)
- structural biology (15)
- systemic risk (15)
- temperature (15)
- teoria crítica (15)
- tissue oxygen partial pressure (15)
- tissue temperature (15)
- Adjunkt <Linguistik> (14)
- Agamben, Giorgio (14)
- Anglizismus (14)
- Arabisch (14)
- Artikulatorische Phonetik (14)
- Asset Pricing (14)
- Aussprache (14)
- Barock (14)
- Bitcoin (14)
- Bulgarisch (14)
- Bürgertum (14)
- Chewa-Sprache (14)
- Chwabo (14)
- Computerspiel (14)
- Cryoelectron microscopy (14)
- DNA (14)
- Döblin, Alfred (14)
- ESR Spectra (14)
- Epistemologie (14)
- Epoche (14)
- Erzählperspektive (14)
- European Central Bank (14)
- Flüchtlinge (14)
- Form (14)
- Fortschritt (14)
- Frieden (14)
- Gattungstheorie (14)
- Gegenwart (14)
- Genossenschaft (14)
- Gentherapie (14)
- Griechenland (14)
- Habermas (14)
- Hadron (14)
- Handel (14)
- Held (14)
- Homosexualität (14)
- Humanismus (14)
- Indien (14)
- Infrastruktur (14)
- Inszenierung (14)
- Israel (14)
- Joyce, James (14)
- Kapitalmarkt (14)
- Kindersprache (14)
- Kommentar (14)
- Krise (14)
- Lernen (14)
- Literarische Gestalt (14)
- Literarische Übersetzung (14)
- Ludwig (14)
- Mathematik (14)
- Molinio-Arrhenatheretea (14)
- Mortality (14)
- Mörike, Eduard (14)
- Mündlichkeit (14)
- Negation (14)
- Neoliberalismus (14)
- New Zealand (14)
- New species (14)
- Nungisch (14)
- Pandemie (14)
- Parkinson’s disease (14)
- Parodie (14)
- Passiv (14)
- Pension (14)
- Philhellenismus (14)
- Private Investment (14)
- Radiotherapy (14)
- Reformation (14)
- Rezeptionsästhetik (14)
- Risikomanagement (14)
- Russia (14)
- Sauerstoffversorgung (14)
- Schwedisch (14)
- Schönheit (14)
- Screening (14)
- Slowakisch (14)
- Sozialer Wandel (14)
- Spitteler, Carl (14)
- Sprachvariante (14)
- Sprichwort (14)
- Strategie (14)
- Subjektivität (14)
- Tastsinn (14)
- Taxonomie (14)
- Terror (14)
- Topographie <Kulturwissenschaft> (14)
- Transfer (14)
- Transformation (14)
- Trauma (14)
- Vokal (14)
- Wagner, Richard (14)
- Walther <von der Vogelweide> (14)
- Weiblichkeit (14)
- Widerstand (14)
- Wissenschaftskommunikation (14)
- Wortschatz (14)
- artificial intelligence (14)
- banking (14)
- cell death (14)
- cirrhosis (14)
- credit risk (14)
- epigenetics (14)
- eutrophication (14)
- extracellular matrix (14)
- financial crisis (14)
- flora (14)
- focus (14)
- insurance (14)
- interculturality (14)
- lectotype (14)
- macrophages (14)
- species delimitation (14)
- tissue blood flow (14)
- ubiquitination (14)
- wound healing (14)
- Analyse (13)
- Andes (13)
- Anti-Utopie (13)
- Apoidea (13)
- Ausländer (13)
- Bachtin, Michail M. (13)
- Barbar <Motiv> (13)
- Bayern (13)
- Biopolitik <Motiv> (13)
- Borges, Jorge Luis (13)
- Bourdieu, Pierre (13)
- Capsule endoscopy (13)
- Clearing (13)
- Cognition (13)
- Croatian language (13)
- Cryptocurrency (13)
- Das Andere (13)
- Deutschlehrer (13)
- Diagnostik (13)
- Ding <Motiv> (13)
- Ecocriticism (13)
- Ecology (13)
- Ecuador (13)
- Energie (13)
- Epidemiology (13)
- Epigenetik (13)
- Faschismus (13)
- Federal Reserve (13)
- Filmtheorie (13)
- Finanzkrise (13)
- Fremdbild (13)
- George, Stefan (13)
- Gesicht <Motiv> (13)
- Großstadt <Motiv> (13)
- HCV (13)
- Habitat (13)
- Heinrich von (13)
- Herder (13)
- Herwegh, Georg (13)
- Identity (13)
- Immunotherapy (13)
- Karikatur (13)
- Kinder- und Hausmärchen (13)
- Kinderschutz (13)
- Klein- und Mittelbetrieb (13)
- Klitisierung (13)
- Kompositum (13)
- Kopula (13)
- Kreativität (13)
- Kulturpolitik (13)
- Lehrmittel (13)
- Literaturkanon (13)
- Luther, Martin (13)
- Mammakarzinom (13)
- Medientheorie (13)
- Middle East (13)
- Moral (13)
- Motivation (13)
- Multikulturelle Gesellschaft (13)
- Multistable figures (13)
- Museum (13)
- NADPH oxidase (13)
- Nation (13)
- Netzpolitik (13)
- Neugriechisch (13)
- Niederländisch (13)
- Oncology (13)
- Oriental Region (13)
- Paul (13)
- Performativität <Kulturwissenschaften> (13)
- Phylogeny (13)
- Possessivität (13)
- Prag (13)
- Predigt (13)
- R2P (13)
- ROS (13)
- Rothacker, Erich (13)
- Römisches Reich (13)
- Saving (13)
- Schrift (13)
- Souveränität (13)
- Spanien (13)
- Sprachgebrauch (13)
- Sprachkompetenz (13)
- Sprachlehrbuch (13)
- Suttner, Bertha von (13)
- Tagalog (13)
- Tanz (13)
- Tastwahrnehmung (13)
- Tempus (13)
- Transylvania (13)
- Ungarn (13)
- Vergangenheitsbewältigung (13)
- Vergesellschaftung (13)
- Verkehr (13)
- Vertrauen (13)
- Volkserzählung (13)
- Zeitgenössische Kunst (13)
- bladder cancer (13)
- caves (13)
- child (13)
- communication (13)
- endemic (13)
- epidemiology (13)
- first record (13)
- fiscal policy (13)
- fungi (13)
- genitalia (13)
- globalization (13)
- hrvatski jezik (13)
- ideology (13)
- islamic state (13)
- liquidity (13)
- meiofauna (13)
- metabolism (13)
- neurodegeneration (13)
- red riječi (13)
- signal transduction (13)
- simulation (13)
- spider (13)
- stress (13)
- survival (13)
- synaptic plasticity (13)
- Öffentlichkeit (13)
- ABS (12)
- Aesthetics (12)
- Afghanistan (12)
- Aktivismus (12)
- Allegorie (12)
- Ambiguität (12)
- Arbeiterinnenfrage (12)
- Arbeiterinnenverein (12)
- Argentina (12)
- Asymmetrische Information (12)
- Auslandsgermanistik (12)
- Autophagy (12)
- Bank Lending (12)
- Behavior (12)
- Berliner Kindheit um neunzehnhundert (12)
- Big Data (12)
- Bioenergetics (12)
- Bloch, Ernst (12)
- Buch (12)
- Börsenrecht (12)
- Bürgerliche Frauenbewegung (12)
- Chronotopos (12)
- Comments disabled (12)
- Consumption (12)
- Datenbank (12)
- Deutsches Sprachgebiet (12)
- Diabetes mellitus (12)
- Divina Commedia (12)
- Dürrenmatt, Friedrich (12)
- Einfühlung (12)
- Endothelial cells (12)
- England (12)
- Familienname (12)
- Faust (12)
- Florenz (12)
- Frauenliteratur (12)
- Germanist (12)
- Geschichte 1450-1650 (12)
- Geschlechterverhältnis (12)
- Gewalt <Motiv> (12)
- Greece (12)
- Grundschule (12)
- Hadron-Hadron scattering (experiments) (12)
- Heros (12)
- Historische Sprachwissenschaft (12)
- History (12)
- Idealisierung (12)
- Intellektueller (12)
- Investmentfonds (12)
- Kamerun (12)
- Kapitalertrag (12)
- Katastrophe <Motiv> (12)
- Kleidung (12)
- Klimaänderung (12)
- Kommunismus (12)
- Konsonant (12)
- Lexikografie (12)
- Massenmedien (12)
- Materialität (12)
- Membranproteine (12)
- MiFID II (12)
- Militär (12)
- Modalverb (12)
- Molecular biology (12)
- Mollusca (12)
- Myanmar (12)
- NMR-Spektroskopie (12)
- Namibia (12)
- Nationalsozialismus <Motiv> (12)
- Neuer Markt (12)
- Ovidius Naso, Publius (12)
- Paratext (12)
- Personenname (12)
- Phänomenologie (12)
- Pinus sylvestris (12)
- Portfolio Selection (12)
- Portugiesisch / Brasilien (12)
- Proust, Marcel (12)
- Psychologie (12)
- Psychology (12)
- Publizistik (12)
- Rechtsradikalismus (12)
- Referenzidentität (12)
- Reise (12)
- Repräsentation (12)
- Revolution (12)
- Rheinland-Pfalz (12)
- Romania (12)
- Rumänien (12)
- Sage (12)
- Sehen (12)
- Semantics (12)
- Sepsis (12)
- Sozialgeschichte (12)
- Spannung (12)
- Stadtentwicklung (12)
- Standardsprache (12)
- Struktur (12)
- Subjekt (12)
- Suffix (12)
- Suicide (12)
- Theodor Adorno (12)
- Topik (12)
- Training (12)
- United States (12)
- Vendée (France) (12)
- Verbreitung (12)
- Vereinte Nationen (12)
- Walser, Robert (12)
- Wirtschaftssprache (12)
- Zeichen (12)
- Zeit <Motiv> (12)
- Zustandsgleichung (12)
- alien species (12)
- alphabetisation (12)
- barcoding (12)
- colorectal cancer (12)
- disturbance (12)
- dry grassland (12)
- financial literacy (12)
- health (12)
- human (12)
- language (12)
- leukemia (12)
- mouse (12)
- new synonym (12)
- orthography (12)
- prevalence (12)
- psoriasis (12)
- restoration (12)
- risk (12)
- semantics (12)
- spiders (12)
- surgery (12)
- syntax (12)
- targeted therapy (12)
- trauma (12)
- validity (12)
- Überwachung (12)
- 5-lipoxygenase (11)
- Ableitung <Linguistik> (11)
- Alphabet (11)
- Alzheimer’s disease (11)
- Anapher <Syntax> (11)
- Arbeitsmarkt (11)
- Arbeitsmarktpolitik (11)
- Archivierung (11)
- Artificial Intelligence (11)
- Arzneimittel (11)
- Aspekt (11)
- Bolivia (11)
- Branching fraction (11)
- Bryophytes (11)
- Bundesverfassungsgericht (11)
- Börsenordnung (11)
- Canguilhem, Georges (11)
- Cerambycidae (11)
- Chatten <Kommunikation> (11)
- Chemotherapy (11)
- Cisena (11)
- Computerphilologie (11)
- Conservation (11)
- Czech Republic (11)
- Derivatives (11)
- Deutsch als Zweitsprache (11)
- Dienstmädchen (11)
- Diplomatie (11)
- Diskriminierung (11)
- Dissertation (11)
- Dokumentation (11)
- Droste-Hülshoff, Annette von (11)
- EGFR (11)
- EIOPA (11)
- Eigenübersetzung (11)
- Einkommensverteilung (11)
- Elektronische Zeitschrift (11)
- Emotions (11)
- Endoscopy (11)
- Europäische Zentralbank (11)
- Evangelischer Arbeiterinnenverein (11)
- Freundschaft (11)
- Geburtenregelung (11)
- Germanistenverband (11)
- Geschichte <Motiv> (11)
- Globalization (11)
- Grimm, Wilhelm (11)
- Guatemala (11)
- Hadron-Hadron Scattering (11)
- Heart failure (11)
- Hegel (11)
- Heidegger, Martin (11)
- Hofmannsthal (11)
- Imagination (11)
- Immunologie (11)
- In vitro (11)
- Inversionsfigur (11)
- Italienbild (11)
- Jahrhundertwende (11)
- Jesus Christus (11)
- Joseph von (11)
- Jürgen Habermas (11)
- Konnotation (11)
- Kontrastive Phraseologie (11)
- Kracauer, Siegfried (11)
- Kredit (11)
- Kulturvermittlung (11)
- Kurzgeschichte (11)
- Lacan, Jacques (11)
- Learning (11)
- Legende (11)
- Leidenschaft (11)
- Liebesbrief (11)
- Life Insurance (11)
- Literaturgattung (11)
- Low Interest Rates (11)
- Makonde-Sprache (11)
- Mali (11)
- Mediterranean (11)
- Melancholie (11)
- Menschenrechte (11)
- Mutterschaft (11)
- Mutterschaftsversicherung (11)
- Optionspreistheorie (11)
- PCR (11)
- Pain (11)
- Peter (11)
- Peter Tauber (11)
- Politische Bildung (11)
- Pop-Kultur (11)
- Prediction (11)
- Preis <Auszeichnung> (11)
- Primary care (11)
- Prostate cancer (11)
- Quark Gluon Plasma (11)
- Quark-Gluon Plasma (11)
- RHIC (11)
- Rechtssprache (11)
- Rousseau, Jean-Jacques (11)
- Saccharomyces cerevisiae (11)
- Scarabaeoidea (11)
- Schizophrenia (11)
- Schutzverantwortung (11)
- Science-Fiction (11)
- Sebald, W. G. (11)
- Seizure (11)
- Selbstbild (11)
- Sena (11)
- Silbe (11)
- Strafrecht (11)
- TLAC (11)
- Textgeschichte (11)
- Theatertheorie (11)
- Tieck, Ludwig (11)
- Tiere <Motiv> (11)
- Transkulturalität (11)
- Uncertainty (11)
- VEGF (11)
- Verfassung (11)
- Verfilmung (11)
- Wahrnehmungswechsel (11)
- Waldgesellschaften (11)
- Weerth, Georg (11)
- Wohnverhältnisse (11)
- Wortfeld (11)
- Zweig, Stefan (11)
- al-Qaida (11)
- asymmetric information (11)
- bees (11)
- biology (11)
- crisis (11)
- deep sea (11)
- exercise (11)
- forest management (11)
- grammar (11)
- grazing (11)
- habitat (11)
- hepatitis C virus (11)
- hydrogen bonding (11)
- infection (11)
- integrins (11)
- intercultural communication (11)
- justice (11)
- macrophage polarization (11)
- magnetic resonance imaging (11)
- male genitalia (11)
- metastasis (11)
- model uncertainty (11)
- morphometry (11)
- outcome (11)
- p53 (11)
- participation (11)
- physical activity (11)
- public debt (11)
- quark gluon plasma (11)
- radiotherapy (11)
- real-time data (11)
- responsibility (11)
- risk factors (11)
- sexual dimorphism (11)
- therapy (11)
- transparency (11)
- vaccination (11)
- vegetation (11)
- Ästhetische Wahrnehmung (11)
- Österreich-Ungarn (11)
- 19. Jahrhundert (10)
- ACLF (10)
- Achtundsechziger (10)
- Aktienkurs (10)
- Anthrozoologie (10)
- Arachnida (10)
- Arbeit <Motiv> (10)
- Arbeitsrecht (10)
- Arbeitsverhältnisse (10)
- Asset Allocation (10)
- Atrial fibrillation (10)
- Autor (10)
- Bankenaufsicht (10)
- Barrierefreiheit (10)
- Barthes, Roland (10)
- Baudelaire, Charles (10)
- Bildungsroman (10)
- Biopolitik (10)
- Boko Haram (10)
- Bratoljub Klaić (10)
- Brustkrebs (10)
- Bundestag (10)
- C. elegans (10)
- CDU (10)
- COPD (10)
- Chile (10)
- Classification (10)
- Costa Rica (10)
- Cyberwar (10)
- Debatte (10)
- Deutsch-Ostafrika (10)
- Diagnostic markers (10)
- Dialektik (10)
- Ding (10)
- Disclosure (10)
- Disticha Catonis (10)
- Diversity (10)
- Educação (10)
- Egypt (10)
- Eichendorff (10)
- Einkommen (10)
- Ellenberg indicator values (10)
- Energieumsatz <Medizin> (10)
- Entstehung (10)
- Erlebnisbericht (10)
- Evolutionspsychologie (10)
- Expressivität <Linguistik> (10)
- Facebook (10)
- Fachinformationsdienst (10)
- Fauna (10)
- Fintech (10)
- Fragebogen (10)
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- Goethe-Universität Frankfurt am Main (10)
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- Recht <Motiv> (10)
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- Lynch, David (Regisseur) (9)
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- Dante, Alighieri (8)
- Der Mann ohne Eigenschaften (8)
- Der Zauberberg (8)
- Developmental biology (8)
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- Nationalsozialistische Deutsche Arbeiterpartei (NSDAP, 1920-) (8)
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- information structure (8)
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- platelets (8)
- polypharmacy (8)
- polytrauma (8)
- precipitation (8)
- pregnancy (8)
- primary care (8)
- problem wounds (8)
- pronunciation (8)
- quark matter (8)
- quark-gluon-plasma (8)
- reconhecimento (8)
- regulatory arbitrage (8)
- reification (8)
- relationship lending (8)
- relationships (8)
- renal cell carcinoma (8)
- screening (8)
- site conditions (8)
- sleep (8)
- solitary bees (8)
- speciation (8)
- species list (8)
- sphingolipids (8)
- sustainability (8)
- systematic review (8)
- taxonomic key (8)
- teacher training (8)
- toxicity (8)
- transcranial magnetic stimulation (8)
- transfer (8)
- ubiquitin (8)
- vegetation structure (8)
- visual cortex (8)
- welfare state (8)
- whiteflies (8)
- wound infections (8)
- Äquivalenz (8)
- 500-1500 (7)
- Ackerunkräuter (7)
- Adaptation (7)
- Aktiengesellschaft (7)
- Aktionär (7)
- Alemão como língua estrangeira (7)
- Alien species (7)
- Allgemeinmedizin (7)
- Alzheimer's disease (7)
- Ambivalenz (7)
- Anpassung (7)
- Anreizsystem (7)
- Anthophila (7)
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- Antifaschismus (7)
- Anura (7)
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- Aphorismus (7)
- Arbeitsvermittlung (7)
- Argumentation (7)
- Atlantic Ocean (7)
- Ausnahmezustand (7)
- Auswanderung (7)
- Autism spectrum disorder (7)
- Azerbaijan (7)
- Baltoslawische Sprachen (7)
- Basidiomycota (7)
- Bayesian estimation (7)
- Behinderung (7)
- Belize (7)
- Benthos (7)
- Bericht (7)
- Beuys, Joseph (7)
- Bindungstheorie <Linguistik> (7)
- Biological invasions (7)
- Biophysical chemistry (7)
- Black holes (7)
- Bobrowski, Johannes (7)
- Brandenburg (7)
- Bremen (7)
- Brüder Grimm (7)
- CRISPR/Cas9 (7)
- Cancer treatment (7)
- Capital-Asset-Pricing-Modell (7)
- Charakterisierung (7)
- Charmonium (7)
- Chemiker (7)
- Chewa (7)
- Chichewa (7)
- Christliche Arbeiterbewegung (7)
- Climate (7)
- Colorectal cancer (7)
- Community ecology (7)
- Computational models (7)
- Consensus (7)
- Corporate Social Responsibility (7)
- Culicidae (7)
- Curculionidae (7)
- Cyanobacteria (7)
- Das Böse (7)
- Das Heilige (7)
- Das Sakrale (7)
- Data processing (7)
- Data science (7)
- Deflation (7)
- Derivat, Wertpapier (7)
- Deutscher Einwanderer (7)
- Deutschland / Vereinigung (7)
- Deutschland <Bundesrepublik> (7)
- Deutschland <DDR> / Revolution <1989> (7)
- Deutschlandbild (7)
- Development (7)
- Dienstmädchenverein (7)
- Digital Rights (7)
- Digital Services Act (7)
- Digitalization (7)
- Dodd-Frank Act (7)
- Drogenkonsum (7)
- Drogenszene (7)
- Drung (7)
- Dung beetles (7)
- EZB (7)
- Eastern Arc (7)
- Eco, Umberto (7)
- Electroencephalography (7)
- Elektronische Bibliothek (7)
- Ellipse <Linguistik> (7)
- Empfindsamkeit (7)
- Empirische Ästhetik (7)
- Engel <Motiv> (7)
- Enzensberger, Hans Magnus (7)
- Epigenetics (7)
- Episches Theater (7)
- Epos (7)
- Erwerbslosigkeit (7)
- Erzähler (7)
- Essayismus (7)
- Ethica ordine geometrico demonstrata (7)
- Ethnizität (7)
- Euro Area (7)
- Europabild (7)
- Expedition Brochure (7)
- Expeditionsbericht (7)
- Exposure (7)
- Fachportal (7)
- Fantastische Literatur (7)
- Fassbinder, Rainer Werner (7)
- Fernunterricht (7)
- Filmkritik (7)
- Finance (7)
- Financial Regulation (7)
- Finanzierungsstruktur (7)
- Flaubert, Gustave (7)
- Foreign language teaching (7)
- Forschungsbericht (7)
- Fragmentation (7)
- Frauenemanzipation (7)
- Frauenpolitik (SDAP) (7)
- Freidenker (7)
- Freie Liebe (7)
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- GARCH (7)
- GIS (7)
- GPCR (7)
- Gegenwartsliteratur (7)
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- Gene regulation (7)
- Genossenschaftliche Frauenbewegung (7)
- Genregulation (7)
- German literature (7)
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- Geschichte 1933-1945 (7)
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- Gesundheitspolitik (7)
- Gewerbeaufsicht (7)
- Goethe-Universität Frankfurt (7)
- Gottsched, Johann Christoph (7)
- Green Finance (7)
- Griechenland (Altertum) (7)
- Guattari, Félix (7)
- HCC (7)
- Harz (7)
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- Husserl, Edmund (7)
- Ich (7)
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- Ikone (7)
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- Indústria cultural (7)
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- Jena (7)
- John (7)
- Johnson, Uwe (7)
- Kannibalismus <Motiv> (7)
- Kapitalgewinn (7)
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- Karl Philipp (7)
- Karriere (7)
- Kasperl (7)
- Katholische Arbeiterinnenbewegung (7)
- Kausalität (7)
- Kenya (7)
- Klopstock, Friedrich Gottlieb (7)
- Komposition <Wortbildung> (7)
- Konfliktlösung (7)
- Kraus, Karl (7)
- Kreditwürdigkeit (7)
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- Kriminalgeschichte (7)
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- Kunstpädagogik (7)
- Kybernetik (7)
- Latein (7)
- Lattice QCD (7)
- Laudatio (7)
- Lebensstil (7)
- Legs (7)
- Leibniz, Gottfried Wilhelm (7)
- Lesekompetenz (7)
- Liberdade (7)
- Linguistische Datenverarbeitung (7)
- Linkshegelianer (7)
- Lycosidae (7)
- MLL (7)
- MSC (7)
- Macaronesia (7)
- Macht <Motiv> (7)
- Machtstruktur (7)
- Makonde (7)
- Malaise trap (7)
- Manga (7)
- Manipulation (7)
- Mann (7)
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- Marcuse (7)
- Martin (7)
- Martyrium (7)
- Marxismus (7)
- Mechanisms of disease (7)
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- Moose (7)
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- Musculoskeletal system (7)
- Märtyrer <Motiv> (7)
- Müller (7)
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- NK cells (7)
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- Nestroy, Johann (7)
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- Numerale (7)
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- Organische Synthese (7)
- Othering (7)
- Outcomes (7)
- PD-L1 (7)
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- PTSD (7)
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- Simmel, Georg (7)
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- Software (7)
- Sozialdemokratische Partei Deutschlands (SPD, 1890-) (7)
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- descriptions (7)
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- perception (7)
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- predictive coding (7)
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- transcription (7)
- transcriptome (7)
- tumor-associated macrophages (7)
- ultrasound (7)
- validation (7)
- vector (7)
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- Ökosystem (7)
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- Kleidung <Motiv> (5)
- Klimaänderung <Motiv> (5)
- Koartikulation (5)
- Kognitionswissenschaft (5)
- Kolonialismus <Motiv> (5)
- Kolonie (5)
- Kommanditgesellschaft auf Aktien (5)
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- Korrelation (5)
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- Kristallisation (5)
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- Lichtenberg, Georg Christoph (5)
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- Liste (5)
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- Liverwort (5)
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- Lukács, Georg (5)
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- MRSA (5)
- Machine-learning (5)
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- Mallarmé, Stéphane (5)
- Mann, Heinrich (5)
- Mann, Thomas / Joseph und seine Brüder (5)
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- Metabolomics (5)
- Meyrink, Gustav (5)
- Michel (5)
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- NO (5)
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- Opitz, Martin (5)
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- Orient <Motiv> (5)
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- Otto-Peters, Louise (5)
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- Paris <Motiv> (5)
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- Predictive markers (5)
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- Prioninae (5)
- Privater Verbrauch (5)
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- Probability distribution (5)
- Produktivität (5)
- Progressive Taxation (5)
- Propaganda (KPD) (5)
- Protein Structure (5)
- Protein folding (5)
- Prädikation (5)
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- Psychiatrie (5)
- Psychiatrie <Motiv> (5)
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- RUCAM (5)
- Raabe, Wilhelm (5)
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- Rationalität (5)
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- Region Rhein-Main (5)
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- Remarque, Erich Maria (5)
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- Revolutionäre Gewerkschaftsopposition (RGO, 1929-) (5)
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- STAT3 (5)
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- Schönberg, Arnold (5)
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- Stirner, Max (5)
- Streptomyces hydrogenans (5)
- Structure (5)
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- Sumatra (5)
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- Teaching (5)
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- Texas (5)
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- Textualität (5)
- Thai (5)
- The Good Samaritan (5)
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- Transcriptome (5)
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- Trauer (5)
- Treatment outcome (5)
- Trichoptera (5)
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- Tumor microenvironment (5)
- Türken (5)
- Türkischer Einwanderer (5)
- Ubiquitin (5)
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- Uganda (5)
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- Wagner, Richard / Tannhäuser (5)
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- Weigel, Sigrid (5)
- Weimarer Beiträge (Zeitschrift) (5)
- Well-being (5)
- Welt (5)
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- Weltkrieg <1914-1918, Motiv> (5)
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- Werfel, Franz (5)
- Wert (5)
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- Wikipedia (5)
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- abundance (5)
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- aptamer (5)
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- catalogue (5)
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- collagen (5)
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- comparison (5)
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- fragmentation (5)
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- gamma (5)
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- lncRNA (5)
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- mPGES-1 (5)
- mRNA (5)
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- measurement (5)
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- similarity (5)
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- topic (5)
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- types (5)
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- werden <Wort> (5)
- yeast (5)
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- zero lower bound (5)
- Ética (5)
- Öffentliche Ausgaben (5)
- Čakavian (5)
- Šalamov, Varlam Tichonovič (5)
- 177Lu-PSMA-617 (4)
- 5-Lipoxygenase (4)
- A clockwork orange (4)
- ABC Transporter (4)
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- AF4 (4)
- ATP (4)
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- Absatzweg (4)
- Aby-M.-Warburg-Preis (4)
- Accounting (4)
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- Adolf Bratoljub Klaić (4)
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- Aesculus hippocastanum (4)
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- Age (4)
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- Agitation (RGO) (4)
- Aichinger, Ilse (4)
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- Analysis (4)
- Anders, Günther (4)
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- Anna Amalia <Sachsen-Weimar-Eisenach, Herzogin> (4)
- Anneke, Mathilde Franziska (4)
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- App <Programm> (4)
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- Bacon, Francis (4)
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- Baden (4)
- Badiou, Alain (4)
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- Barck, Karlheinz (4)
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- Basler Konzil (1431-1449 : Basel) (4)
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- Biller, Maxim (4)
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- Prinz Friedrich von Homburg (4)
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- Proteorhodopsin (4)
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- RCT (4)
- RDF (4)
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- RFQ-Beschleuniger (4)
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- Revolution <Motiv> (4)
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- Rječnik stranih riječi (4)
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- Rolf Dieter (4)
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- Rückert, Friedrich (4)
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- Schelling, Friedrich Wilhelm Joseph von (4)
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- Schmitt, Carl (4)
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- Se questo è un uomo (4)
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- Seghers, Anna (4)
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- Sexualaufklärung (4)
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- Tolstoj, Lev Nikolaevič (4)
- Tools and resources (4)
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- Verband Süddeutscher Katholischer Arbeiterinnenvereine (1906-) (4)
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- Zentralverband der Hausangestellten Deutschlands (1909-) (4)
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- ribosome (4)
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- risk transfer (4)
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- time (4)
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Institute
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We report a new measurement of the production cross section for inclusive electrons from open heavy-flavor hadron decays as a function of transverse momentum (pT) at mid-rapidity (|y|< 0.7) in p+p collisions at s√=200 GeV. The result is presented for 2.5 <pT< 10 GeV/c with an improved precision above 6 GeV/c with respect to the previous measurements, providing more constraints on perturbative QCD calculations. Moreover, this measurement also provides a high-precision reference for measurements of nuclear modification factors for inclusive electrons from open-charm and -bottom hadron decays in heavy-ion collisions.
Partons traversing the strongly interacting medium produced in heavy-ion collisions are expected to lose energy depending on their color charge and mass. We measure the nuclear modification factors for charm- and bottom-decay electrons, defined as the ratio of yields, scaled by the number of binary nucleon-nucleon collisions, in sNN−−−√ = 200 GeV Au+Au collisions to p+p collisions (RAA), or in central to peripheral Au+Au collisions (RCP). We find the bottom-decay electron RAA and RCP to be significantly higher than that of charm-decay electrons. Model calculations including mass-dependent parton energy loss in a strongly coupled medium are consistent with the measured data. These observations provide clear evidence of mass ordering of charm and bottom quark energy loss when traversing through the strongly coupled medium created in heavy-ion collisions.
Partons traversing the strongly interacting medium produced in heavy-ion collisions are expected to lose energy depending on their color charge and mass. We measure the nuclear modification factors for charm- and bottom-decay electrons, defined as the ratio of yields, scaled by the number of binary nucleon-nucleon collisions, in sNN−−−√ = 200 GeV Au+Au collisions to p+p collisions (RAA), or in central to peripheral Au+Au collisions (RCP). We find the bottom-decay electron RAA and RCP to be significantly higher than that of charm-decay electrons. Model calculations including mass-dependent parton energy loss in a strongly coupled medium are consistent with the measured data. These observations provide clear evidence of mass ordering of charm and bottom quark energy loss when traversing through the strongly coupled medium created in heavy-ion collisions.
Partons traversing the strongly interacting medium produced in heavy-ion collisions are expected to lose energy depending on their color charge and mass. We measure the nuclear modification factors for charm- and bottom-decay electrons, defined as the ratio of yields, scaled by the number of binary nucleon-nucleon collisions, in sNN−−−√ = 200 GeV Au+Au collisions to p+p collisions (RAA), or in central to peripheral Au+Au collisions (RCP). We find the bottom-decay electron RAA and RCP to be significantly higher than that of charm-decay electrons. Model calculations including mass-dependent parton energy loss in a strongly coupled medium are consistent with the measured data. These observations provide clear evidence of mass ordering of charm and bottom quark energy loss when traversing through the strongly coupled medium created in heavy-ion collisions.
Partons traversing the strongly interacting medium produced in heavy-ion collisions are expected to lose energy depending on their color charge and mass. We measure the nuclear modification factors for charm- and bottom-decay electrons, defined as the ratio of yields, scaled by the number of binary nucleon-nucleon collisions, in sNN−−−√ = 200 GeV Au+Au collisions to p+p collisions (RAA), or in central to peripheral Au+Au collisions (RCP). We find the bottom-decay electron RAA and RCP to be significantly higher than that of charm-decay electrons. Model calculations including mass-dependent parton energy loss in a strongly coupled medium are consistent with the measured data. These observations provide clear evidence of mass ordering of charm and bottom quark energy loss when traversing through the strongly coupled medium created in heavy-ion collisions.
Partons traversing the strongly interacting medium produced in heavy-ion collisions are expected to lose energy depending on their color charge and mass. We measure the nuclear modification factors for charm- and bottom-decay electrons, defined as the ratio of yields, scaled by the number of binary nucleon-nucleon collisions, in sNN−−−√ = 200 GeV Au+Au collisions to p+p collisions (RAA), or in central to peripheral Au+Au collisions (RCP). We find the bottom-decay electron RAA and RCP to be significantly higher than that of charm-decay electrons. Model calculations including mass-dependent parton energy loss in a strongly coupled medium are consistent with the measured data. These observations provide clear evidence of mass ordering of charm and bottom quark energy loss when traversing through the strongly coupled medium created in heavy-ion collisions.
In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in sNN−−−√ = 3 GeV Au+Au collisions. In this paper, we report measurements of the first-order and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in sNN−−−√ = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC.
In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in sNN−−−√ = 3 GeV Au+Au collisions. In this paper, we report measurements of the first- and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in sNN−−−√ = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC.
A linearly polarized photon can be quantized from the Lorentz-boosted electromagnetic field of a nucleus traveling at ultrarelativistic speed. When two relativistic heavy nuclei pass one another at a distance of a few nuclear radii, the photon from one nucleus may interact through a virtual quark-antiquark pair with gluons from the other nucleus, forming a short-lived vector meson (e.g., ρ0). In this experiment, the polarization was used in diffractive photoproduction to observe a unique spin interference pattern in the angular distribution of ρ0 → π+π− decays. The observed interference is a result of an overlap of two wave functions at a distance an order of magnitude larger than the ρ0 travel distance within its lifetime. The strong-interaction nuclear radii were extracted from these diffractive interactions and found to be 6.53 ± 0.06 fm (197Au) and 7.29 ± 0.08 fm (238U), larger than the nuclear charge radii. The observable is demonstrated to be sensitive to the nuclear geometry and quantum interference of nonidentical particles. Polarized photon-gluon fusion reveals quantum wave interference of non-identical particles and shape of high-energy nuclei.
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
We report cumulants of the proton multiplicity distribution from dedicated fixed-target Au+Au collisions at sNN−−−√ = 3.0 GeV, measured by the STAR experiment in the kinematic acceptance of rapidity (y) and transverse momentum (pT) within −0.5<y<0 and 0.4<pT<2.0 GeV/c. In the most central 0--5\% collisions, a proton cumulant ratio is measured to be C4/C2=−0.85±0.09 (stat.)±0.82 (syst.), which is less than unity, the Poisson baseline. The hadronic transport UrQMD model reproduces our C4/C2 in the measured acceptance. Compared to higher energy results and the transport model calculations, the suppression in C4/C2 is consistent with fluctuations driven by baryon number conservation and indicates an energy regime dominated by hadronic interactions. These data imply that the QCD critical region, if created in heavy-ion collisions, could only exist at energies higher than 3\,GeV.
Two-particle correlations on transverse rapidity in Au+Au collisions at √sNN = 200 GeV at STAR
(2022)
Two-particle correlation measurements projected onto two-dimensional, transverse rapidity coordinates (yT1,yT2), allow access to dynamical properties of the QCD medium produced in relativistic heavy-ion collisions that angular correlation measurements are not sensitive to. We report non-identified charged-particle correlations for Au + Au minimum-bias collisions at sNN−−−√ = 200 GeV taken by the STAR experiment at the Relativistic Heavy-Ion Collider (RHIC). Correlations are presented as 2D functions of transverse rapidity for like-sign, unlike-sign and all charged-particle pairs, as well as for particle pairs whose relative azimuthal angles lie on the near-side, the away-side, or at all relative azimuth. The correlations are constructed using charged particles with transverse momentum pT≥0.15 GeV/c, pseudorapidity from −1 to 1, and azimuthal angles from −π to π. The significant correlation structures that are observed evolve smoothly with collision centrality. The major correlation features include a saddle shape plus a broad peak with maximum near yT≈3, corresponding to pT≈ 1.5 GeV/c. The broad peak is observed in both like- and unlike-sign charge combinations and in near- and away-side relative azimuthal angles. The all-charge, all-azimuth correlation measurements are compared with the theoretical predictions of {\sc hijing} and {\sc epos}. The results indicate that the correlations for peripheral to mid-central collisions can be approximately described as a superposition of nucleon + nucleon collisions with minimal effects from the QCD medium. Strong medium effects are indicated in mid- to most-central collisions.
A linearly polarized photon can be quantized from the Lorentz-boosted electromagnetic field of a nucleus traveling at ultra-relativistic speed. When two relativistic heavy nuclei pass one another at a distance of a few nuclear radii, the photon from one nucleus may interact through a virtual quark-antiquark pair with gluons from the other nucleus forming a short-lived vector meson (e.g. ρ0). In this experiment, the polarization was utilized in diffractive photoproduction to observe a unique spin interference pattern in the angular distribution of ρ0→π+π− decays. The observed interference is a result of an overlap of two wave functions at a distance an order of magnitude larger than the ρ0 travel distance within its lifetime. The strong-interaction nuclear radii were extracted from these diffractive interactions, and found to be 6.53±0.06 fm (197Au) and 7.29±0.08 fm (238U), larger than the nuclear charge radii. The observable is demonstrated to be sensitive to the nuclear geometry and quantum interference of non-identical particles.
Notwithstanding decades of progress since Yukawa first developed a description of the force between nucleons in terms of meson exchange, a full understanding of the strong interaction remains a major challenge in modern science. One remaining difficulty arises from the non-perturbative nature of the strong force, which leads to the phenomenon of quark confinement at distances on the order of the size of the proton. Here we show that in relativistic heavy-ion collisions, where quarks and gluons are set free over an extended volume, two species of produced vector (spin-1) mesons, namely ϕ and K∗0, emerge with a surprising pattern of global spin alignment. In particular, the global spin alignment for ϕ is unexpectedly large, while that for K∗0 is consistent with zero. The observed spin-alignment pattern and magnitude for the ϕ cannot be explained by conventional mechanisms, while a model with a connection to strong force fields, i.e. an effective proxy description within the Standard Model and Quantum Chromodynamics, accommodates the current data. This connection, if fully established, will open a potential new avenue for studying the behaviour of strong force fields.
The strong force, as one of the four fundamental forces at work in the universe, governs interactions of quarks and gluons, and binds together the atomic nucleus. Notwithstanding decades of progress since Yukawa first developed a description of the force between nucleons in terms of meson exchange, a full understanding of the strong interaction remains a major challenge in modern science. One remaining difficulty arises from the non-perturbative nature of the strong force, which leads to the phenomenon of quark confinement at distance scales on the order of the size of the proton. Here we show that in relativistic heavy-ion collisions, where quarks and gluons are set free over an extended volume, two species of produced vector (spin-1) mesons, namely ϕ and K∗0, emerge with a surprising pattern of global spin alignment. In particular, the global spin alignment for ϕ is unexpectedly large, while that for K∗0 is consistent with zero. The observed spin-alignment pattern and magnitude for the ϕ cannot be explained by conventional mechanisms, while a model with strong force fields accommodates the current data. This is the first time that the strong force field is experimentally supported as a key mechanism that leads to global spin alignment. We extract a quantity proportional to the intensity of the field of the strong force. Within the framework of the Standard Model, where the strong force is typically described in the quark and gluon language of Quantum Chromodynamics, the field being considered here is an effective proxy description. This is a qualitatively new class of measurement, which opens a new avenue for studying the behaviour of strong force fields via their imprint on spin alignment.
The strong force, as one of the four fundamental forces at work in the universe, governs interactions of quarks and gluons, and binds together the atomic nucleus. Notwithstanding decades of progress since Yukawa first developed a description of the force between nucleons in terms of meson exchange, a full understanding of the strong interaction remains a major challenge in modern science. One remaining difficulty arises from the non-perturbative nature of the strong force, which leads to the phenomenon of quark confinement at distance scales on the order of the size of the proton. Here we show that in relativistic heavy-ion collisions, where quarks and gluons are set free over an extended volume, two species of produced vector (spin-1) mesons, namely ϕ and K∗0, emerge with a surprising pattern of global spin alignment. In particular, the global spin alignment for ϕ is unexpectedly large, while that for K∗0 is consistent with zero. The observed spin-alignment pattern and magnitude for the ϕ cannot be explained by conventional mechanisms, while a model with strong force fields accommodates the current data. This is the first time that the strong force field is experimentally supported as a key mechanism that leads to global spin alignment. We extract a quantity proportional to the intensity of the field of the strong force. Within the framework of the Standard Model, where the strong force is typically described in the quark and gluon language of Quantum Chromodynamics, the field being considered here is an effective proxy description. This is a qualitatively new class of measurement, which opens a new avenue for studying the behaviour of strong force fields via their imprint on spin alignment.
In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in √sNN = 3 GeV Au+Au collisions. In this paper, we report measurements of the first- and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in √sNN = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC.
We report on the measurements of directed flow v1 and elliptic flow v2 for hadrons (π±, K ±, K0 S , p, φ, Λ and ) from Au+Au collisions at √sN N = 3 GeV and v2 for (π±, K ±, p and p) at 27 and 54.4 GeV with the STAR experiment. While at the two higher energy midcentral collisions the numberof-constituent-quark (NCQ) scaling holds, at 3 GeV the v2 at midrapidity is negative for all hadrons and the NCQ scaling is absent. In addition, the v1 slopes at midrapidity for almost all observed hadrons are found to be positive, implying dominant repulsive baryonic interactions. The features of negative v2 and positive v1 slope at 3 GeV can be reproduced with a baryonic mean-field in transport model calculations. These results imply that the medium in such collisions is likely characterized by baryonic interactions.
Measurement of cold nuclear matter effects for inclusive J/ψ in p+Au collisions at √sNN = 200 GeV
(2022)
Measurement by the STAR experiment at RHIC of the cold nuclear matter (CNM) effects experienced by inclusive J/ψ at mid-rapidity in 0-100% p+Au collisions at √sNN = 200 GeV is presented. Such effects are quantified utilizing the nuclear modification factor, RpAu, obtained by taking a ratio of J/ψ yield in p+Au collisions to that in p+p collisions scaled by the number of binary nucleon-nucleon collisions. The differential J/ψ yield in both p+p and p+Au collisions is measured through the dimuon decay channel, taking advantage of the trigger capability provided by the Muon Telescope Detector in the RHIC 2015 run. Consequently, the J/ψ RpAu is derived within the transverse momentum (pT) range of 0 to 10 GeV/c. A suppression of approximately 30% is observed for pT < 2 GeV/c, while J/ψ RpAu becomes compatible with unity for pT greater than 3 GeV/c, indicating the J/ψ yield is minimally affected by the CNM effects at high pT. Comparison to a similar measurement from 0-20% central Au+Au collisions reveals that the observed strong J/ψ suppression above 3 GeV/c is mostly due to the hot medium effects, providing strong evidence for the formation of the quark-gluon plasma in these collisions. Several model calculations show qualitative agreement with the measured J/ψ RpAu, while their agreement with the J/ψ yields in p+p and p+Au collisions is worse.
We report the first multi-differential measurements of strange hadrons of K −, φ and − yields as well as the ratios of φ/K − and φ/− in Au+Au collisions at √sNN = 3 GeV with the STAR experiment fixed target configuration at RHIC. The φ mesons and − hyperons are measured through hadronic decay channels, φ → K + K − and Ξ− → Λπ−. Collision centrality and rapidity dependence of the transverse momentum spectra for these strange hadrons are presented. The 4π yields and ratios are compared to thermal model and hadronic transport model predictions. At this collision energy, thermal model with grand canonical ensemble (GCE) under-predicts the φ/K − and φ/− ratios while the result of canonical ensemble (CE) calculations reproduce φ/K −, with the correlation length rc ∼ 2.7 fm, and φ/−, rc ∼ 4.2 fm, for the 0-10% central collisions. Hadronic transport models including high mass resonance decays could also describe the ratios. While thermal calculations with GCE work well for strangeness production in high energy collisions, the change to CE at 3 GeV implies a rather different medium property at high baryon density.
Measurements of mass and Λ binding energy of 4ΛH and 4ΛHe in Au+Au collisions at sNN−−−√=3 GeV are presented, with an aim to address the charge symmetry breaking (CSB) problem in hypernuclei systems with atomic number A = 4. The Λ binding energies are measured to be 2.22±0.06(stat.)±0.14(syst.) MeV and 2.38±0.13(stat.)±0.12(syst.) MeV for 4ΛH and 4ΛHe, respectively. The measured Λ binding-energy difference is 0.16±0.14(stat.)±0.10(syst.) MeV for ground states. Combined with the γ-ray transition energies, the binding-energy difference for excited states is −0.16±0.14(stat.)±0.10(syst.) MeV, which is negative and comparable to the value of the ground states within uncertainties. These new measurements on the Λ binding-energy difference in A = 4 hypernuclei systems are consistent with the theoretical calculations that result in ΔB4Λ(1+exc)≈−ΔB4Λ(0+g.s.)<0 and present a new method for the study of CSB effect using relativistic heavy-ion collisions.
Measurements of mass and Λ binding energy of 4ΛH and 4ΛHe in Au+Au collisions at sNN−−−√=3 GeV are presented, with an aim to address the charge symmetry breaking (CSB) problem in hypernuclei systems with atomic number A = 4. The Λ binding energies are measured to be 2.22±0.06(stat.)±0.14(syst.) MeV and 2.38±0.13(stat.)±0.12(syst.) MeV for 4ΛH and 4ΛHe, respectively. The measured Λ binding-energy difference is 0.16±0.14(stat.)±0.10(syst.) MeV for ground states. Combined with the γ-ray transition energies, the binding-energy difference for excited states is −0.16±0.14(stat.)±0.10(syst.) MeV, which is negative and comparable to the value of the ground states within uncertainties. These new measurements on the Λ binding-energy difference in A = 4 hypernuclei systems are consistent with the theoretical calculations that result in ΔB4Λ(1+exc)≈−ΔB4Λ(0+g.s.)<0 and present a new method for the study of CSB effect using relativistic heavy-ion collisions.
Measurements of mass and Λ binding energy of 4ΛH and 4ΛHe in Au+Au collisions at sNN−−−√=3 GeV are presented, with an aim to address the charge symmetry breaking (CSB) problem in hypernuclei systems with atomic number A = 4. The Λ binding energies are measured to be 2.22±0.06(stat.)±0.14(syst.) MeV and 2.38±0.13(stat.)±0.12(syst.) MeV for 4ΛH and 4ΛHe, respectively. The measured Λ binding-energy difference is 0.16±0.14(stat.)±0.10(syst.) MeV for ground states. Combined with the γ-ray transition energies, the binding-energy difference for excited states is −0.16±0.14(stat.)±0.10(syst.) MeV, which is negative and comparable to the value of the ground states within uncertainties. These new measurements on the Λ binding-energy difference in A = 4 hypernuclei systems are consistent with the theoretical calculations that result in ΔB4Λ(1+exc)≈−ΔB4Λ(0+g.s.)<0 and present a new method for the study of CSB effect using relativistic heavy-ion collisions.
Azimuthal anisotropy measurement of (multi-)strange hadrons in Au+Au collisions at √sNN = 54.4 GeV
(2023)
Azimuthal anisotropy of produced particles is one of the most important observables used to access the collective properties of the expanding medium created in relativistic heavy-ion collisions. In this paper, we present second (v2) and third (v3) order azimuthal anisotropies of K0S, ϕ, Λ, Ξ and Ω at mid-rapidity (|y|<1) in Au+Au collisions at sNN−−−√ = 54.4 GeV measured by the STAR detector. The v2 and v3 are measured as a function of transverse momentum and centrality. Their energy dependence is also studied. v3 is found to be more sensitive to the change in the center-of-mass energy than v2. Scaling by constituent quark number is found to hold for v2 within 10%. This observation could be evidence for the development of partonic collectivity in 54.4 GeV Au+Au collisions. Differences in v2 and v3 between baryons and anti-baryons are presented, and ratios of v3/v3/22 are studied and motivated by hydrodynamical calculations. The ratio of v2 of ϕ mesons to that of anti-protons (v2(ϕ)/v2(p¯)) shows centrality dependence at low transverse momentum, presumably resulting from the larger effects from hadronic interactions on anti-proton v2.
We report the measurement of K∗0 meson at midrapidity (|y|< 1.0) in Au+Au collisions at sNN−−−√~=~7.7, 11.5, 14.5, 19.6, 27 and 39 GeV collected by the STAR experiment during the RHIC beam energy scan (BES) program. The transverse momentum spectra, yield, and average transverse momentum of K∗0 are presented as functions of collision centrality and beam energy. The K∗0/K yield ratios are presented for different collision centrality intervals and beam energies. The K∗0/K ratio in heavy-ion collisions are observed to be smaller than that in small system collisions (e+e and p+p). The K∗0/K ratio follows a similar centrality dependence to that observed in previous RHIC and LHC measurements. The data favor the scenario of the dominance of hadronic re-scattering over regeneration for K∗0 production in the hadronic phase of the medium.
We report a measurement of cumulants and correlation functions of event-by-event proton multiplicity distributions from fixed-target Au+Au collisions at sNN−−−√ = 3 GeV measured by the STAR experiment. Protons are identified within the rapidity (y) and transverse momentum (pT) region −0.9<y<0 and 0.4<pT<2.0 GeV/c in the center-of-mass frame. A systematic analysis of the proton cumulants and correlation functions up to sixth-order as well as the corresponding ratios as a function of the collision centrality, pT, and y are presented. The effect of pileup and initial volume fluctuations on these observables and the respective corrections are discussed in detail. The results are compared to calculations from the hadronic transport UrQMD model as well as a hydrodynamic model. In the most central 5\% collisions, the value of proton cumulant ratio C4/C2 is negative, drastically different from the values observed in Au+Au collisions at higher energies. Compared to model calculations including Lattice QCD, a hadronic transport model, and a hydrodynamic model, the strong suppression in the ratio of C4/C2 at 3 GeV Au+Au collisions indicates an energy regime dominated by hadronic interactions.
We present the first measurements of transverse momentum spectra of π±, K±, p(p¯) at midrapidity (|y|<0.1) in U+U collisions at √sNN = 193 GeV with the STAR detector at the Relativistic Heavy Ion Collider (RHIC). The centrality dependence of particle yields, average transverse momenta, particle ratios and kinetic freeze-out parameters are discussed. The results are compared with the published results from Au+Au collisions at sNN−−−−√= 200 GeV in STAR. The results are also compared to those from A Multi Phase Transport (AMPT) model.
Elliptic flow measurements from two-, four- and six-particle correlations are used to investigate flow fluctuations in collisions of U+U at sNN−−−√ = 193 GeV, Cu+Au at sNN−−−√ = 200 GeV and Au+Au spanning the range sNN−−−√ = 11.5 - 200 GeV. The measurements show a strong dependence of the flow fluctuations on collision centrality, a modest dependence on system size, and very little if any, dependence on particle species and beam energy. The results, when compared to similar LHC measurements, viscous hydrodynamic calculations, and Glauber model eccentricities, indicate that initial-state-driven fluctuations predominate the flow fluctuations generated in the collisions studied.
Elliptic flow measurements from two-, four- and six-particle correlations are used to investigate flow fluctuations in collisions of U+U at sNN−−−√= 193 GeV, Cu+Au at sNN−−−√= 200 GeV and Au+Au spanning the range sNN−−−√= 11.5 - 200 GeV. The measurements show a strong dependence of the flow fluctuations on collision centrality, a modest dependence on system size, and very little if any, dependence on particle species and beam energy. The results, when compared to similar LHC measurements, viscous hydrodynamic calculations, and T$\mathrel{\protect\raisebox{-2.1pt}{R}}$ENTo model eccentricities, indicate that initial-state-driven fluctuations predominate the flow fluctuations generated in the collisions studied.
We report high-precision measurements of the longitudinal double-spin asymmetry, 𝐴𝐿𝐿, for midrapidity inclusive jet and dijet production in polarized 𝑝𝑝 collisions at a center-of-mass energy of √𝑠=200 GeV. The new inclusive jet data are sensitive to the gluon helicity distribution, Δ𝑔(𝑥,𝑄2), for gluon momentum fractions in the range from 𝑥≃0.05 to 𝑥≃0.5, while the new dijet data provide further constraints on the 𝑥 dependence of Δ𝑔(𝑥,𝑄2). The results are in good agreement with previous measurements at √𝑠=200 GeV and with recent theoretical evaluations of prior world data. Our new results have better precision and thus strengthen the evidence that Δ𝑔(𝑥,𝑄2) is positive for 𝑥>0.05.
We present the first inclusive measurements of the invariant and SoftDrop jet mass in proton-proton collisions at s√=200 GeV at STAR. The measurements are fully corrected for detector effects, and reported differentially in both the jet transverse momentum and jet radius parameter. We compare the measurements to established leading-order Monte Carlo event generators and find that STAR-tuned PYTHIA-6 reproduces the data, while LHC tunes of PYTHIA-8 and HERWIG-7 do not agree with the data, providing further constraints on parameter tuning. Finally, we observe that SoftDrop grooming, for which the contribution of wide-angle non-perturbative radiation is suppressed, shifts the jet mass distributions into closer agreement with the partonic jet mass as determined by both PYTHIA-8 and a next-to-leading-logarithmic accuracy perturbative QCD calculation. These measurements complement recent LHC measurements in a different kinematic region, as well as establish a baseline for future jet mass measurements in heavy-ion collisions at RHIC.
We report a systematic measurement of cumulants, Cn, for net-proton, proton and antiproton, and correlation functions, κn, for proton and antiproton multiplicity distributions up to the fourth order in Au+Au collisions at sNN−−−√ = 7.7, 11.5, 14.5, 19.6, 27, 39, 54.4, 62.4 and 200 GeV. The Cn and κn are presented as a function of collision energy, centrality and kinematic acceptance in rapidity, y, and transverse momentum, pT. The data were taken during the first phase of the Beam Energy Scan (BES) program (2010 -- 2017) at the Relativistic Heavy Ion Collider (RHIC) facility. The measurements are carried out at midrapidity (|y|< 0.5) and transverse momentum 0.4 < pT < 2.0 GeV/c, using the STAR detector at RHIC. We observe a non-monotonic energy dependence (sNN−−−√ = 7.7 -- 62.4 GeV) of the net-proton C4/C2 with the significance of 3.1σ for the 0-5\% central Au+Au collisions. This is consistent with the expectations of critical fluctuations in a QCD-inspired model. Thermal and transport model calculations show a monotonic variation with sNN−−−√. For the multiparticle correlation functions, we observe significant negative values for a two-particle correlation function, κ2, of protons and antiprotons, which are mainly due to the effects of baryon number conservation. Furthermore, it is found that the four-particle correlation function, κ4, of protons plays a role in determining the energy dependence of proton C4/C1 below 19.6 GeV, which cannot be solely understood by the negative values of κ2 for protons.
We report a systematic measurement of cumulants, Cn, for net-proton, proton and antiproton multiplicity distributions, and correlation functions, κn, for proton and antiproton multiplicity distributions up to the fourth order in Au+Au collisions at sNN−−−√ = 7.7, 11.5, 14.5, 19.6, 27, 39, 54.4, 62.4 and 200 GeV. The Cn and κn are presented as a function of collision energy, centrality and kinematic acceptance in rapidity, y, and transverse momentum, pT. The data were taken during the first phase of the Beam Energy Scan (BES) program (2010 -- 2017) at the BNL Relativistic Heavy Ion Collider (RHIC) facility. The measurements are carried out at midrapidity (|y|< 0.5) and transverse momentum 0.4 < pT < 2.0 GeV/c, using the STAR detector at RHIC. We observe a non-monotonic energy dependence (sNN−−−√ = 7.7 -- 62.4 GeV) of the net-proton C4/C2 with the significance of 3.1σ for the 0-5\% central Au+Au collisions. This is consistent with the expectations of critical fluctuations in a QCD-inspired model. Thermal and transport model calculations show a monotonic variation with sNN−−−√. For the multiparticle correlation functions, we observe significant negative values for a two-particle correlation function, κ2, of protons and antiprotons, which are mainly due to the effects of baryon number conservation. Furthermore, it is found that the four-particle correlation function, κ4, of protons plays a role in determining the energy dependence of proton C4/C1 below 19.6 GeV, which cannot be understood by the effect of baryon number conservation.
Rationale: The AMP-activated protein kinase (AMPK) is stimulated by hypoxia, and although the AMPKα1 catalytic subunit has been implicated in angiogenesis, little is known about the role played by the AMPKα2 subunit in vascular repair.
Objective: To determine the role of the AMPKα2 subunit in vascular repair.
Methods and Results: Recovery of blood flow after femoral artery ligation was impaired (>80%) in AMPKα2-/- versus wild-type mice, a phenotype reproduced in mice lacking AMPKα2 in myeloid cells (AMPKα2ΔMC). Three days after ligation, neutrophil infiltration into ischemic limbs of AMPKα2ΔMC mice was lower than that in wild-type mice despite being higher after 24 hours. Neutrophil survival in ischemic tissue is required to attract monocytes that contribute to the angiogenic response. Indeed, apoptosis was increased in hypoxic neutrophils from AMPKα2ΔMC mice, fewer monocytes were recruited, and gene array analysis revealed attenuated expression of proangiogenic proteins in ischemic AMPKα2ΔMC hindlimbs. Many angiogenic growth factors are regulated by hypoxia-inducible factor, and hypoxia-inducible factor-1α induction was attenuated in AMPKα2-deficient cells and accompanied by its enhanced hydroxylation. Also, fewer proteins were regulated by hypoxia in neutrophils from AMPKα2ΔMC mice. Mechanistically, isocitrate dehydrogenase expression and the production of α-ketoglutarate, which negatively regulate hypoxia-inducible factor-1α stability, were attenuated in neutrophils from wild-type mice but remained elevated in cells from AMPKα2ΔMC mice.
Conclusions: AMPKα2 regulates α-ketoglutarate generation, hypoxia-inducible factor-1α stability, and neutrophil survival, which in turn determine further myeloid cell recruitment and repair potential. The activation of AMPKα2 in neutrophils is a decisive event in the initiation of vascular repair after ischemia.
Medicinal plants represent a big reservoir for discovering new drugs against all kinds of diseases including inflammation. In spite the large number of promising anti-inflammatory plant extracts and isolated components, research on medicinal plants proves to be very difficult. Based on that background this review aims to provide a summarized insight into the hitherto known pharmacologically active concentrations, bioavailability, and clinical efficacy of boswellic acids, curcumin, quercetin and resveratrol. These examples have in common that the achieved plasma concentrations were found to be often far below the determined IC50 values in vitro. On the other hand demonstrated therapeutic effects suggest a necessity of rethinking our pharmacokinetic understanding. In this light this review discusses the value of plasma levels as pharmacokinetic surrogates in comparison to the more informative value of tissue concentrations. Furthermore the need for new methodological approaches is addressed like the application of combinatorial approaches for identifying and pharmacokinetic investigations of active multi-components. Also the physiological relevance of exemplary in vitro assays and absorption studies in cell-line based models is discussed. All these topics should be ideally considered to avoid inaccurate predictions for the efficacy of herbal components in vivo and to unlock the “black box” of herbal mixtures.
Heute gewinnen pflanzliche Arzneimittel im Zeichen einer verstärkten Hinwendung zu natürlichen, relativ nebenwirkungsarmen Medikamenten zunehmend an Bedeutung, so auch die über Jahrtausende hinweg traditionell angewandte Ginsengwurzel (Panax ginseng) und der Indische Weihrauch (Boswellia serrata). Neben der Struktur- und Extraktanalytik konzentriert sich die Forschung in zunehmenden Maße darauf, die zahlreichen pharmakologisch untersuchten und klinisch beobachteten Wirkungen dieser beiden Arzneipflanzen einzelnen Inhaltsstoffen zuzuordnen. Bei der Ginsengwurzel gestaltet sich dies jedoch besonders schwierig. Dies ist begründet durch die große Anzahl strukturell ähnlicher Ginsenoside sowie durch deren unterschiedlicher Metabolismus. Zwar ist aus In-vitro-Experimenten bekannt, daß die Degradation über die stufenweise Deglukosylierung stattfindet, allerdings ist bislang nicht geklärt, ob intakte Ginsenoside überhaupt resorbiert werden und welche der vielen in vitro ermittelten Degradationsprodukte tatsächlich den systemischen Kreislauf erreichen. Anders als bei Ginseng, kann die therapeutische Wirkung des Indischen Weihrauches wohl definierten Inhaltsstoffen, AKBA und KBA, zugeschrieben werden. Dennoch mangelt es hier an verlässlichen pharmakokinetischen Daten, da bislang keine validierte bioanalytische Methode zur Verfügung stand. Im Rahmen der Bioanalytik von Ginsenosiden und Boswellliasäuren kamen in der vorliegenden Arbeit die Nano-ESI-MS(n)-Technik sowie die HPLC-Analytik zur Anwendung. Bereits bei der Strukturanalyse von Ginsenosiden erwies sich die Kombination der Nano-ESI-Technik mit MS(n)-Experimenten in einer Quadrupol-Ionenfalle als besonders vorteilhaft. Im Vergleich zu konventionellem ESI bietet Nano-ESI nicht nur den Vorzug, mit kleinsten Substanzmengen lange Messungen durchführen zu können, sondern auch den Vorteil einer effektiveren, weniger diskreminierenden Ionisation. Sowohl die hohe Sensitivität der Nano-Elektrosprayionisierung bei der Analyse von glykosidischen Verbindungen als auch die umfangreichen Strukturinformationen infolge mehrerer aufeinanderfolgender stoßinduzierter Fragmentierungen machen diese Technik zu einer attraktiven und effizienten Methode zur Analyse von Ginsenosiden. In MS(n)-Experimenten äußert sich das charakteristische Fragmentierungsverhalten der Ginsenoside in der sequentiellen Abspaltung der Zuckereinheiten in sukkzessiven Fragmentierungsschritten. Mit dieser Methode konnten die Zuckerketten an verschiedenen Positionen des Protopanaxadiol- bzw. Protopanaxatriolaglykons der Ginsenoside identifiziert, die glykosidischen Verknüpfungen innerhalb der einzelnen Zuckereinheiten durch spezifische Ringfragmente bestimmt und die genaue(n) Verknüpfungsposition(en) enzymatisch eingeführter Galaktose(n) lokalisiert werden. Bisher wurden allerdings Nano-ESI-MS/MS bzw. MS(n)-Untersuchungen primär an wässrigen oder organischen Lösungen von isolierten / aufgereinigten Stoffen oder Stoffgemischen durchgeführt. In dieser Arbeit wurde erstmals diese Technik in der Bioanalytik zur Identifizierung von Ginsenosiden und deren Degradationsprodukte in Humanplasma und -urin angewandt. Obwohl die optimale Analytkonzentration für die Nano-Elektrosprayionisierung im allgemeinen bei 10-5M liegt, ist es gelungen, die Ginsenoside anhand ihrer spezifischen Fragmentionen im MS/MS Modus bis zu einer Konzentration von 2 ng/mL (10-8M) in biologischen Matrices nachzuweisen. Auch wenn die Molekülionenpeaks bei diesen geringen Konzentrationen im Rauschen untergehen, können die Ginsenoside durch selektive Isolierung der gewünschten Vorläuferionen und deren anschließende Fragmentierung in der Quadrupol-Ionenfalle auf der Basis der Detektion spezifischer Fragmente identifiziert werden. Da bei der Fragmentierung der gleichen Vorläuferionenmasse in Leerplasma bzw. Urin keine charakteristischen Fragmentionen gebildet werden, handelt es sich somit um einen spezifischen Nachweis der Ginsenoside in biologischen Matrices. Vor dem Hintergrund dieser vielversprechenden Vorversuche wurde eine Pilotstudie zum qualitativen Screening von Ginsenosiden und deren Metaboliten in Humanplasma und –urin durchgeführt. Es konnte gezeigt werden, daß Protopanaxatriol-Ginsenoside sowohl im Magen hydrolysiert als auch intestinal degradiert werden. Schon in den ersten Stunden nach der einmaligen oralen Einnahme von Ginsana G115 Kapseln wurden die Hydrolyseprodukte G-Rh1 und hydratisiertes G-Rh1 in Humanplasma detektiert. Die schnelle Resorption dieser beiden Verbindungen aus dem oberen Gastrointestinaltrakt deutet auf die Hydrolyse des Ginsenosides Rg1 im Magen hin. Das spätere Auftreten eines weiteren monoglukosylierten Protopanaxatriols, des Degradationsproduktes G-F1, liefert den ersten In-Vivo-Hinweis auf einen intestinalen Metabolismus von Protopanaxatriol-Ginsenoside. Im Gegensatz zu den Protopanaxatriolginsenosiden passieren die Protopanaxadiol-Ginsenoside den Magen unverändert, wie aus der Abwesenheit jeglicher Protopanaxadiol-Degradationsprodukte im Plasma und Urin in den ersten Stunden nach der Applikation geschlossen werden kann. Erst im unteren Gastrointestinaltrakt werden Protopanaxadiol-Ginsenoside durch intestinale Bakterien zu „Compound-K“ abgebaut und anschließend resorbiert. Der Nachweis von Ginsenosid Rb1 im Plasma, sowie weiterer Ginsenoside im Urin eines Probanden zeigt, daß auch Ginsenoside in ihrer intakten Form resorbiert werden können. Dennoch sind weitere Studien hierzu notwendig, um zu klären, ob die Resorption intakter Ginsenoside die Regel oder eher eine Ausnahme darstellt. Mit der Identifizierung des Hydrolyseproduktes G-Rh1, der Degradationsprodukte G-F1 sowie „Compound-K“ in Humanplasma und -urin konnte schließlich die Frage geklärt werden, welche der zahlreichen in vitro bestimmten Degradationsprodukte tatsächlich den systemischen Kreislauf erreichen. Damit ist die Basis für eine spätere Quantifizierung dieser Verbindungen nach ihrer Isolierung bzw. Herstellung und Charakterisierung als Referenzsubstanzen geschaffen. Außerdem können diese neuen Erkenntnisse helfen, pharmakologische Ergebnisse aus In-vitro-Versuchen mit In-vivo-Daten besser zu korrelieren, da sie erste Hinweise geben, welche der in vitro getesteten Substanzen für die in vivo beobachteten Effekte verantwortlich sein könnten. Bisher wurde Nano-ESI-MS(n) in der Bioanalytik pflanzlicher Arzneistoffe nicht eingesetzt. In dieser Arbeit wurde diese Technik erstmals zum Screening von Ginsenosiden und deren Degradationsprodukte in Humanplasma und –urin benutzt. Darüber hinaus konnte gezeigt werden, daß Nano-ESI-MS(n) auch eine empfindliche und sensitive Methode zur Identifizierung und zum Nachweis anderer medizinisch relevanter glykosidischer Verbindungen in biologischen Matrices darstellt, woraus sich neue Perspektiven für den Einsatz dieser Technik in der Metabolitenforschung sowie in der Bioanalytik pflanzlicher Xenobiotika ergeben. In den letzten Jahren rückte auch der Indische Weihrauch immer mehr in den Mittelpunkt des wissenschaftlichen sowie therapeutischen Interesses. Aufgrund der selektiven Hemmung der 5-Lipoxygenase gewinnen AKBA und KBA, als neue entzündungshemmende Verbindungen, zunehmend an Bedeutung. Während die quantitative Analytik der Boswelliasäuren in Extrakten und in verschiedenen Fertigarzneimitteln erhebliche Fortschritte erzielen konnte, fehlten auf dem Gebiet der Bioanalytik bislang validierte analytische Methoden zur Durchführung pharmakokinetischer Studien. Vor diesem Hintergrund wurde eine HPLC-Methode zur Bestimmung von KBA in Humanplasma entwickelt und validiert. Die Methode ist durch eine einfache Probenvorbereitung gekennzeichnet, die sich auf eine Festphasenextraktion der KBA aus der komplex zusammengesetzten biologischen Matrix beschränkt. Im Anschluß an die chromatographische Trennung auf einer RP-C18 Säule erfolgt die Quantifizierung der KBA mittels UV-Detektion bei 250 nm. Um eine adäquate Bestimmung der KBA in Humanplasma zu gewährleisten, wurde eine umfassende Validierung durchgeführt. Alle ermittelten Validierungsparameter, wie Spezifität, Linearität, Präzision, Richtigkeit, Reproduzierbarkeit, untere Quantifizierungsgrenze und Stabilität lagen innerhalb der vorgegebenen Grenzen. Damit erfüllt die entwickelte HPLC-Methode die allgemein gültigen Anforderungen an die Validierung bioanalytischer Methoden. Mit der Erstellung einer Plasmakonzentrations-Zeit-Kurve im Rahmen einer ersten Pilotstudie konnte diese Methode zudem ihre praktische Anwendbarkeit unter Beweis stellen. Somit steht für zukünftige pharmakokinetische Studien eine validierte HPLC-Analytik zur Bestimmung von KBA, einer der Hauptwirkstoffe des Indischen Weihrauches, zur Verfügung, die sich durch hohe Spezifität, Reproduzierbarkeit und Präzision auszeichnet. Verlässliche Daten zur Pharmakokinetik am Menschen sind heute von besonderer Bedeutung, da sie helfen, die Dosierung zu optimieren, die biopharmazeutischen Eigenschaften von Präparaten zu verbessern und die Sicherheit bei der Anwendung zu erhöhen. Insbesondere im Hinblick auf bereits festgestellte Interaktionen von pflanzlichen Arzneimitteln mit Medikamenten reicht es nicht mehr aus, wenn sich pflanzliche Arzneimittel, wie beispielsweise Ginseng und Indischer Weihrauch, nur auf ihre langjährigen tradierten Anwendungserfahrungen berufen. So wird auch bei Phytopharmaka in verstärktem Maße eine wissenschaftliche Absicherung durch bioanalytische Forschung erwartet. Mit der Identifizierung der Ginsenoside und deren Degradationsprodukte im Menschen, der erstmaligen Anwendung von Nano-ESI-MS(n) in der Metabolitenforschung und der Entwicklung einer validierten bioanalytischen Methode zur Bestimmung der 11-Keto-Beta-Boswelliasäure in Humanplasma wurde diesen Erfordernissen Rechnung getragen.
Dosing accuracy of two disposable insulin pens according to new ISO 11608-1: 2012 requirements.
(2015)
OBJECTIVE: The aim was to compare 2 disposable insulin pens, FlexTouch® (Novo Nordisk, insulin aspart) and SoloSTAR® (Sanofi, insulin glulisine), according to new ISO 11608-1:2012 requirements for dosing accuracy.
METHODS: Sixty pens of each type were tested at 1, 40, and 80 U doses. Following the new ISO requirements, each dose was delivered from the front, middle, and rear one-third of the pen. Statistical analysis was performed using Student's t test.
RESULTS: Both pens delivered all doses within ISO limits. The difference between the average measured dose and the target dose was significantly smaller for SoloSTAR than FlexTouch at 40 U (P = .009) and 80 U (P = .008), but not at 1 U (P = .417).
CONCLUSION: Both insulin pens fulfilled the dosing accuracy requirements defined by ISO 11608-1:2012 at all 3 dosage levels.
We study forward-backward charge fluctuations to probe the correlations among produced particles in ultra relativistic heavy ion collisions. We develop a model that describes the forward-backward dynamical fluctuations and apply it to interpret the recent PHOBOS data. Within the present model, the dynamical fluctuations are related to the particle production mechanism via cluster decay and to long range correlations between the forward and backward rapidity hemispheres. We argue that with a tight centrality cut, PHOBOS may see a strong decrease of the dynamical fluctuations. Within the present model, this deterioration of the correlation among the produced hadrons can be interpreted as a sign for the production of a hot, dense and interacting medium.
The utilization of Ginkgo biloba in medicinal practice dates back to 1505 A.D. Ironically, the mechanisms of action of Ginkgo are not fully clarified till now. Nowadays, Ginkgo biloba leaf extracts are mainly indicated for mild to moderate cerebrovascular insufficiency and different forms of dementia. The fact that it is an herbal extract composed of several different components indeed adds to the intricacy of finding its mechanisms of actions. Indisputably, many scientists tried to elucidate the mechanisms of actions of Ginkgo. The first step to achieve this goal was to standardize the leaf extract. The standardized Ginkgo leaf extract contains 22-27 % flavonol glycosides, 2.8-3.4 % of ginkgolide A, B and C, as well as approximately 2.6-3.2 % bilobalide and below 5 ppm ginkgolic acids. A widespread standardized Ginkgo extract is the EGb 761, which was utilized in the current work. One of the earliest proposed mechanisms is the ability of the Ginkgo extract to act as an anti-oxidant, which could be explained by its high flavonoid contents. However, without doubt EGb 761 encompasses other characteristics which distinguish it from other herbal extracts that are also rich in flavonoids. Since free radicals and reactive oxygen species are highly associated with the mitochondrial functions, examination of the effect of EGb 761 on mitochondrial functions was lately addressed. Moreover, this was encouraged as the link between Alzheimer’s disease [AD] and the mitochondria started to emerge. Previously, our group observed mitochondrial protective actions of EGb 761 on cell culture in vitro. Furthermore, anti-apoptotic effects were previously described for EGb 761. However, only very few studies addressed the single constituents and their effect on mitochondrial functions. Flavonoids were studied in several other plant extracts and their radical scavenging activity is unquestionable, but EGb 761 has anti-apoptotic actions which may be attributed to its terpenoid fraction. Exclusively found in the Ginkgo plant, are the ginkgolides and therefore their actions are not yet fully elucidated. Moreover, those who attempted to address these constituents concentrated on one or two candidates, for example bilobalide or ginkgolide B and ignored the rest. Unfortunately, this led to incomplete results, and one couldn’t compare the relative activities of all EGb 761 components in order to state whether all the components are effective or not. ...
Optimal investment decisions by institutional investors require accurate predictions with respect to the development of stock markets. Motivated by previous research that revealed the unsatisfactory performance of existing stock market prediction models, this study proposes a novel prediction approach. Our proposed system combines Artificial Intelligence (AI) with data from Virtual Investment Communities (VICs) and leverages VICs’ ability to support the process of predicting stock markets. An empirical study with two different models using real data shows the potential of the AI-based system with VICs information as an instrument for stock market predictions. VICs can be a valuable addition but our results indicate that this type of data is only helpful in certain market phases.
Artificial Intelligence (AI) and Machine Learning (ML) are currently hot topics in industry and business practice, while management-oriented research disciplines seem reluctant to adopt these sophisticated data analytics methods as research instruments. Even the Information Systems (IS) discipline with its close connections to Computer Science seems to be conservative when conducting empirical research endeavors. To assess the magnitude of the problem and to understand its causes, we conducted a bibliographic review on publications in high-level IS journals. We reviewed 1,838 articles that matched corresponding keyword-queries in journals from the AIS senior scholar basket, Electronic Markets and Decision Support Systems (Ranked B). In addition, we conducted a survey among IS researchers (N = 110). Based on the findings from our sample we evaluate different potential causes that could explain why ML methods are rather underrepresented in top-tier journals and discuss how the IS discipline could successfully incorporate ML methods in research undertakings.
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery. We now studied in a porcine model whether LIM may have beneficial effects on cardiac function after CPB. Methods German landrace pigs underwent CPB (60 min myocardial ischemia; 30 min reperfusion)without (group I; n=6) or with LIM (group II; n=6). The cardiac indices (CI) and cardiac function were analyzed pre and post CPB with a Swan-Ganz catheter and the cardiac function analyzer. Neutrophil labeling with technetium, scintigraphy, and histological analyses were done to track activated neutrophils within the organs. Results LIM prevented CPB-associated increase of neutrophil counts in peripheral blood. In group I, the CI significantly declined post CPB (post: 3.26 +/- 0.31; pre: 4.05 +/- 0.45 l/min/m2; p<0.01). In group II, the CI was only slightly reduced (post: 3.86 +/- 0.49; pre 4.21 +/- 1.32 l/min/m2; p=0.23). Post CPB, the intergroup difference showed significantly higher CI values in the LIM group (p<0.05) which was in conjunction with higher pre-load independent endsystolic pressure volume relationship (ESPVR) values (group I: 1.57 +/- 0.18; group II: 1.93 +/- 0.16; p<0.001). Moreover, the systemic vascular resistance and pulmonary vascular resistance were lower in the LIM group. LIM appeared to accelerate the sequestration of hyperactivated neutrophils in the spleen and to reduce neutrophil infiltration of heart and lung. Conclusions Our data provide strong evidence that LIM improves perioperative hemodynamics and cardiac function after CPB by limiting neutrophil activity and inducing accelerated sequestration of neutrophils in the spleen.
Die vorliegende Untersuchung befasst sich mit verschiedenen Aspekten des Frauenbilds sowohl in der deutschen als auch in der arabischen bzw. orientalischen Literatur des Mittelalters.
Zu den untersuchenden Aspekten gehören zum Beispiel die Stellung der Frau in der Gesellschaft sowohl religiös als auch sozial, Rolle und Einfluss der Frau, Beschreibung der Schönheit der Frau, Beziehung zwischen Mann und Frau, Minne als Zentralmotiv, Ehe als sozialbedingte Lebensform sowie adlige Dame und bäuerliche Frau als Gegenbild.
Die Forschung wird sich auf bestimmte Textsorten der mittelalterlichen Literatur stützen, um mittels dieser induktiven Methode ein konkretes Bild zu geben und die verschiedenen Hauptelemente der Untersuchung zu betonen.
Diese Werke sind die klassischen höfischen Artusromane z.B. Erec, Iwein, Parzival und Tristan und Isolde in der deutschen Literatur des Mittelalters sowie Erzählungen aus der Geschichtensammlung von 1001 Nacht, der Antarroman und die Geschichte von Laila und Madjnun in der orientalischen Literatur des Mittelalters.
Das Bild der Frau ist ein Thema, das bis heute ein Schwerpunkt in vielen literarischen Werken bildet, der aber während der gesamten Epoche des Mittelalters eine besondere Bedeutung hatte. Das könnte auf die unterschiedlichen Darstellungsweisen vom Bild der Frau zurückzuführen, und wie sie in den verschiedenen Kulturen zum Ausdruck gebracht werden.
In “Fern von Aleppo”, the Syrian author Faisal Hamdo, who left his home in 2014 and sought refuge in Germany, tells of his very personal integration experiences. The book represents a kind of intercultural communication. In his book, Faisal Hamdo, who sees himself as a “mediator between the worlds”, tries to give the German reader answers to many questions regarding Syrian culture. From a text linguistic point of view, this book identifies the narrative development that seems to be tailored to the in-tercultural context. Accordingly, the present article raises the following questions: Does the structure of classic narration differ from the structure of narration in an intercultural context? Which intercultural information units are presented in the text? How are they embedded in the narrative text? Which constituents of the narrative structure are suitable for realizing intercultural communication? Which communicative functions do the constituents of the narrative structure fulfill in an intercultural context? The contribution sets itself the goal of analyzing the narrative structure to investigate how intercultural communication comes about through narration, how the intercultural information units are integrated into the constituents of the classic narrative structure so that they fulfill their communicative function, and to developa suitable analysis model.
Objective: The aim of this study was to report the basic cerebrospinal fluid (CSF) profile in patients with primary progressive multiple sclerosis (PPMS).
Methods: The results of CSF analysis from 254 patients with PPMS were collected at four university hospitals in Germany. Routine CSF parameters and different indices of intrathecal immunoglobulin synthesis were evaluated. We assessed possible correlations between the various CSF parameters and the expanded disability status scale (EDSS) both at the time of lumbar puncture and during the course of the disease.
Results: The median cell count and albumin concentration in the CSF did not deviate from normal values. The CSF-serum albumin-quotient (QALB) was elevated in 29.6% of the patients, while intrathecal immunoglobulin G (IgG) oligoclonal bands (OCBs) were detected in 91.1% of the patients. CSF-lactate levels as well as local IgM- and IgA-synthesis were correlated with the yearly disease progression rate, as assessed by EDSS.
Conclusion: We present the results of the hitherto largest and most detailed CSF biomarker profile in a cohort of 254 patients with PPMS. As reported previously, OCBs are the most sensitive marker for intrathecal IgG synthesis. CSF-lactate concentrations are positively correlated with the progression rate, which might suggest that mitochondrial dysfunction plays a relevant role in PPMS. The negative correlation between intrathecally produced IgM and IgA and disease progression may indicate their hitherto unexplored protective role.
18-OH-Corticosteron (18 ) wird als die unmittelbare Vorstufe der Aldosteron-Synthese angesehen. In-vitro-Untersuchungen sowie vereinzelten klinischen Beobachtungen zufolge sollen Nebennierenrinden-Adenome, im Gegensatz zu Nebennierenrinden-Hyperplasie, vermehrt 8- bilden. In der vorliegenden Studie wurde an 1.272 Patienten einer Hochdruckambulanz, wobei bei 84 Patienten mit primärem Aldosteronismus infolge eines Adenoms sowie bei 110 Patienten infolge einer Nebennierenrinden-Hyperplasie die Diagnose gesichert werden konnte, der diagnostische Stellenwert von 8- im Vergleich zu den Aldosteron-Metaboliten Aldosteron-18-Glucuronid (ALD-18-G) und Tetrahydroaldosteron (TH-ALD) untersucht. Dies im Hin blick auf: 1. die Erkennung eines primären Aldosteronismus, und 2. der differentialdiagnostischen Unterscheidung zwischen einem Adenom und einer Hyperpläsie.
Bezüglich der ersten Fragestellung wurde für 18-OHB - hinsichtlich der Unterscheidung zwischen dem primären Aldosteronismus infolge eines Adenoms und einer essentiellen Hypertonie-eine diagnostische Sensitivität von 99,2% bei einer diagnostischen Spezifität von 95,2% berechnet. Deutlich geringer war mit einer diagnostischen Sensitivität von 79,7% bei einer diagnostischen Spezifität von 60,9% die Abgrenzung zwischen dem primären Aldosteronismus infolge einer Hyperpläsie und einer essentiellen Hypertonie.
18-OHB war bei 11 der 84 Adenom- und 5 der 110 Hyperplasie-Patienten zunächst das einzig erhöhte Steroid im 24 h-Urin. Bei ihnen konnte erst innerhalb einer bis zu 2jährigen Beobachtungszeit ein langsamer Anstieg der Aldosteron-Metabolite beobachtet werden. Somit stellt das 18-OHB einen „Frühmarker" der Erkrankung dar.
In der Unterscheidung zwischen einem Nebennierenrinden-Adenom und einer -Hyperplasie besitzt 18-OHB mit einer diagnostischen Sensitivität von 84,5% bei einer diagnostischen Spezifität von 96,4% ein höheres Abgrenzungsvermögen als Tetrahydro-Aldosteron und Aldosteron-18-Glucuronid dar.
Für die Unterscheidung des Adenoms von der Hyperpläsie ließ sich für 18-OH-Corticosteron im 24 h-Urin ein Wert von 7,9 [ig/die als eine optimale Diskriminanzschwelle berechnen. Bei einer höheren Ausscheidung ist in 84,5% der Fälle mit einem Nebennierenrinden-Adenom zu rechnen. Hinsichtlich der diagnostischen Wertung von 18-OHB sind weder geschlechts- noch altersspezifische Abhängigkeiten zu berücksichtigen.
Die Bestimmung von Tetrahydro-Aldosteron (oder Aldosteron-18-Glucuronid) in Kombination mit 18-OH-Corticosteron stellt die optimale Methode zur Diagnostik des primären Hyperaldosteronismus, insbesondere infolge eines Adenoms, dar.
Tibnīn was an important small Crusader fief and a fortified castle. It was vital for the Kingdom of Jerusalem, because it included fertile agricultural lands, was a tax collection centre, and because it controlled the Damascus-to-Tyre commercial route. Additionally, its castle played defensive and offensive role in the north of the Kingdom of Jerusalem and upper Galilee, and its rulers of Tibnīn played a major role in forming the history of the Latin East. When the Crusaders invaded the Levant at the end of the eleventh century, it was given rise to new demographic, cultural, socio-economic, and architectural features. The present Paper aims at removing some of the mystery concerning the fief of Tibnīn and its castle in the Latin East. This paper thus is a study of the demographic structure of Tibnīn and discusses the socio-economic role of Tibnīn in the Latin east. Moreover, the role of Tibnīn in influencing the relations between Muslims and the Crusaders in the Levant and the architecture of the castle of Tibnīn and its importance in the age of the Crusade will be examined.