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Myocardial injury as induced by myocardial infarction results in tissue ischemia, which critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring oxygen and nutrient supply to the heart. Latest advances in single-cell multi-omics, together with genetic lineage tracing, reveal a transcriptional and phenotypical adaptation to the injured microenvironment, which includes alterations in metabolic, mesenchymal, hematopoietic and pro-inflammatory signatures. The extent of transition in mesenchymal or hematopoietic cell lineages is still debated, but it is clear that several of the adaptive phenotypical changes are transient and endothelial cells revert back to a naïve cell state after resolution of injury responses. This resilience of endothelial cells to acute stress responses is important for preventing chronic dysfunction. Here, we summarize how endothelial cells adjust to injury and how this dynamic response contributes to repair and regeneration. We will highlight intrinsic and microenvironmental factors that contribute to endothelial cell resilience and may be targetable to maintain a functionally active, healthy microcirculation.
In recent years, research in parsing has extended in several new directions. One of these directions is concerned with parsing languages other than English. Treebanks have become available for many European languages, but also for Arabic, Chinese, or Japanese. However, it was shown that parsing results on these treebanks depend on the types of treebank annotations used. Another direction in parsing research is the development of dependency parsers. Dependency parsing profits from the non-hierarchical nature of dependency relations, thus lexical information can be included in the parsing process in a much more natural way. Especially machine learning based approaches are very successful (cf. e.g.). The results achieved by these dependency parsers are very competitive although comparisons are difficult because of the differences in annotation. For English, the Penn Treebank has been converted to dependencies. For this version, Nivre et al. report an accuracy rate of 86.3%, as compared to an F-score of 92.1 for Charniaks parser. The Penn Chinese Treebank is also available in a constituent and a dependency representations. The best results reported for parsing experiments with this treebank give an F-score of 81.8 for the constituent version and 79.8% accuracy for the dependency version. The general trend in comparisons between constituent and dependency parsers is that the dependency parser performs slightly worse than the constituent parser. The only exception occurs for German, where F-scores for constituent plus grammatical function parses range between 51.4 and 75.3, depending on the treebank, NEGRA or TüBa-D/Z. The dependency parser based on a converted version of Tüba-D/Z, in contrast, reached an accuracy of 83.4%, i.e. 12 percent points better than the best constituent analysis including grammatical functions.
The prefix cyber, prepended onto terms like war, peace, security, and so on, results in interesting word combinations which we construct with our spoken language. Many scholars, from political to social science, have discussed the terms and the semantics of it in order to understand the problem and to create some scientific value out of it. But this article will not be another endless discussion on whether cyberfoo exists somewhere in any computer network at the moment or not...
Sperber and Wilson (1996) and Wilson and Sperber (1993) have argued that communication involves two processes, ostension and inference, but they also assume there is a coding-decoding stage of communication and a functional distinction between lexical items and grammatical marking (what they call 'conceptual' vs. 'procedural' information). Sperber and Wilson have accepted a basically Chomskyan view of the innateness of language structure and Universal Grammar.
The bail-in tool as implemented in the European bank resolution framework suffers from severe shortcomings. To some extent, the regulatory framework can remedy the impediments to the desirable incentive effect of private sector involvement (PSI) that emanate from a lack of predictability of outcomes, if it compels banks to issue a sufficiently sized minimum of high-quality, easy to bail-in (subordinated) liabilities. Yet, even the limited improvements any prescription of bail-in capital can offer for PSI’s operational effectiveness seem compromised in important respects.
The main problem, echoing the general concerns voiced against the European bail-in regime, is that the specifications for minimum requirements for own funds and eligible liabilities (MREL) are also highly detailed and discretionary and thus alleviate the predicament of investors in bail-in debt, at best, only insufficiently. Quite importantly, given the character of typical MREL instruments as non-runnable long-term debt, even if investors are able to gauge the relevant risk of PSI in a bank’s failure correctly at the time of purchase, subsequent adjustment of MREL-prescriptions by competent or resolution authorities potentially change the risk profile of the pertinent instruments. Therefore, original pricing decisions may prove inadequate and so may market discipline that follows from them.
The pending European legislation aims at an implementation of the already complex specifications of the Financial Stability Board (FSB) for Total Loss Absorbing Capacity (TLAC) by very detailed and case specific amendments to both the regulatory capital and the resolution regime with an exorbitant emphasis on proportionality and technical fine-tuning. What gets lost in this approach, however, is the key policy objective of enhanced market discipline through predictable PSI: it is hardly conceivable that the pricing of MREL-instruments reflects an accurate risk-assessment of investors because of the many discretionary choices a multitude of agencies are supposed to make and revisit in the administration of the new regime. To prove this conclusion, this chapter looks in more detail at the regulatory objectives of the BRRD’s prescriptions for MREL and their implementation in the prospectively amended European supervisory and resolution framework.
The bail-in tool as implemented in the European bank resolution framework suffers from severe shortcomings. To some extent, the regulatory framework can remedy the impediments to the desirable incentive effect of private sector involvement (PSI) that emanate from a lack of predictability of outcomes, if it compels banks to issue a sufficiently sized minimum of high-quality, easy to bail-in (subordinated) liabilities. Yet, even the limited improvements any prescription of bail-in capital can offer for PSI’s operational effectiveness seem compromised in important respects.
The main problem, echoing the general concerns voiced against the European bail-in regime, is that the specifications for minimum requirements for own funds and eligible liabilities (MREL) are also highly detailed and discretionary and thus alleviate the predicament of investors in bail-in debt, at best, only insufficiently. Quite importantly, given the character of typical MREL instruments as non-runnable long-term debt, even if investors are able to gauge the relevant risk of PSI in a bank’s failure correctly at the time of purchase, subsequent adjustment of MREL-prescriptions by competent or resolution authorities potentially change the risk profile of the pertinent instruments. Therefore, original pricing decisions may prove inadequate and so may market discipline that follows from them.
The pending European legislation aims at an implementation of the already complex specifications of the Financial Stability Board (FSB) for Total Loss Absorbing Capacity (TLAC) by very detailed and case specific amendments to both the regulatory capital and the resolution regime with an exorbitant emphasis on proportionality and technical fine-tuning. What gets lost in this approach, however, is the key policy objective of enhanced market discipline through predictable PSI: it is hardly conceivable that the pricing of MREL-instruments reflects an accurate risk-assessment of investors because of the many discretionary choices a multitude of agencies are supposed to make and revisit in the administration of the new regime. To prove this conclusion, this chapter looks in more detail at the regulatory objectives of the BRRD’s prescriptions for MREL and their implementation in the prospectively amended European supervisory and resolution framework.
Why MREL won’t help much
(2017)
The fear that with the existence of an unconditional basic income sufficient for living many people would cease to engage in a productive life, would only relax, consume and devote to having fun, can be addressed from different perspectives. One of these is the sociology of religion, which allows elaborating the argument that with such a way of life the question about the meaning of life cannot be answered. But this "meaning question", the whole research within the field of the sociology of religion speaks for this, compellingly must be answered by each life praxis. It cannot remain unanswered, as is said already in the Bible: "Man does not live on bread alone, [but on every word that comes from the mouth of God.]" (5. Moses 8.3, Matthew 4.4, Lukas 4.4) The paper examines the reasons of this fact and its consequences in regard to a life with an unconditional basic income sufficient for living.
Event-related potential (ERP) data in monolingual German speakers have shown that sentential metric expectancy violations elicit a biphasic ERP pattern consisting of an anterior negativity and a posterior positivity (P600). This pattern is comparable to that elicited by syntactic violations. However, proficient French late learners of German do not detect violations of metric expectancy in German. They also show qualitatively and quantitatively different ERP responses to metric and syntactic violations. We followed up the questions whether (1) latter evidence results from a potential pitch cue insensitivity in speech segmentation in French speakers, or (2) if the result is founded in rhythmic language differences. Therefore, we tested Spanish late learners of German, as Spanish, contrary to French, uses pitch as a segmentation cue even though the basic segmentation unit is the same in French and Spanish (i.e., the syllable). We report ERP responses showing that Spanish L2 learners are sensitive to syntactic as well as metric violations in German sentences independent of attention to task in a P600 response. Overall, the behavioral performance resembles that of German native speakers. The current data suggest that Spanish L2 learners are able to extract metric units (trochee) in their L2 (German) even though their basic segmentation unit in Spanish is the syllable. In addition Spanish in contrast to French L2 learners of German are sensitive to syntactic violations indicating a tight link between syntactic and metric competence. This finding emphasizes the relevant role of metric cues not only in L2 prosodic but also in syntactic processing.
Lack of transparency and accountability in the planning practice allow for misuse and abuse of the planning system to serve the interests of the more powerful and influential groups, including those entrusted with the powers of planning. The outcomes of a non-inclusive, non-transparent and insensitive planning include: insecurity of land tenure rights and subsequently investments in land; poverty; informal land subdivision and building; unplanned spatial growth and endless conflicts in land development. These are detrimental to the residents and erode their trust and confidence in the government. It takes an organized, informed, confident and courageous group of residents or community to reject the non-inclusive form of planning and cause adoption of inclusive and collaborative planning that allows them space in the planning process. The achievement of such an organized group ? a turn towards democratic planning practice ? leads to a conclusion that informed, organized, confident and courageous civil society is a pillar of democracy. This book therefore argues that ineffective planning results, among other things, from defective land policy and legislation, and planning inability to recognize and make use of opportunities for shaping the built environment.
A link between populism and social media is often suspected. This paper spells out a set of possible mechanisms underpinning this link: that social media changes the communication structure of the public sphere, making it harder for citizens to obtain evidence that refutes populist assumptions. By developing a model of the public sphere, four core functions of the public sphere are identified: exposing citizens to diverse information, promoting equality of deliberative opportunity, creating deliberative transparency, and producing common knowledge. A wellworking public sphere allows citizens to learn that there are genuine disagreements among citizens that are held in good faith. Social media makes it harder to gain this insight, opening the door for populist ideology.
Valadkhani, Adrian ; Profe, Jonas Benedikt ; Kreisel, Andreas ; Hirschfeld, Peter J. ; Valentí, Roser
canning tunneling microscopy (STM) is perhaps the most promising way to detect the superconducting gap size and structure in the canonical unconventional superconductor Sr2RuO4 directly. However, in many cases, researchers have reported being unable to detect the gap at all in simple STM conductance measurements. Recently, an investigation of this issue on various local topographic structures on a Sr-terminated surface found that superconducting spectra appeared only in the region of small nanoscale canyons, corresponding to the removal of one RuO surface layer. Here, we analyze the electronic structure of various possible surface structures using first principles methods, and argue that bulk conditions favorable for superconductivity can be achieved when removal of the RuO layer suppresses the RuO4 octahedral rotation locally. We further propose alternative terminations to the most frequently reported Sr termination where superconductivity surfaces should be observed.
While both Japanese and English have a grammatic al form denoting the progressive, the two forms (te-iru & be+ing) interact differently with the inherent semantics of the verb to which they attach (Kindaichi, 1950; McClure, 1995; Shirai, 2000). Japanese change of state verbs are incompatible with a progressive interpretation, allowing only a resultative interpretation of V+ te-iru, while a progressive interpretation is preferred for activity predicates. English be+ing denotes a progressive interpretation regardless of the lexical semantics of the verb. The question that arises is how we can account for the fact that change of state verbs like dying can denote a progressive interpretation in English, but not in Japanese. While researchers such as Kageyama (1996) and Ogihara (1998, 1999) propose that the difference lies in the lexical semantics of the verbs themselves, others such as McClure (1995) have argued that the difference lies in the semantics of the grammatical forms, be+ing and te-iru. We present results from an experimental study of Japanese learners’ interpretation of the English progressive which provide support for McClure’s proposal. Results indicate that independent of verb type, learners had significantly more difficulty with the past progressive. We argue that knowledge of L2 semantics-syntax correspondences proceeds not on the basis of L1 lexical semantic knowledge, but on the basis of grammatical forms.
This policy letter provides evidence for the crucial importance of the initial regulatory treatment for the further development of financial innovations by exploring the emergence and initial legal framing of off-balance-sheet leasing in Germany. Due to a missing legal framework, lease contracts occurred as an innovative social practice of off-balance-sheet financing. However, this lacking legal framing impeded the development of this financial innovation as it also created legal uncertainties. This was about to change after the initial legal framing of leasing in the 1970’s which eliminated those legal uncertainties and off-balance-sheet leasing entered into a stunning period of growth while laying the foundation of a regulatory resiliency against efforts that seek to abandon the off-balance-sheet treatment of leases. As the initial legal framing is crucial for the further development of a financial innovation, we propose the French approach for the initial vindication of new financial products in which the principles-based rules are aligned with the capabilities of regulators to intervene, even when a financial innovation complies with the letter of the law. In this way, regulators could regulate the frontier of financial innovations and weed out those which are entirely or mainly driven by regulatory arbitrage considerations while maintaining the beneficial elements of those products.
Last November, the media organisation of the „Islamic State“ (IS) published a video, the sole purpose of which was to prove that the „caliphate“ which the IS has established in June 2014 was in fact a proper state. The video highlighted a host of institutions in order to drive home the claim of real statehood, including examples like a working judiciary, a prison administration, a schooling system, and so on. At one point in the video, the IS claimed that it was also financially independent and had apt resources at its disposal, namely oil and gas.
However, while it is true that the IS controls a number of oil and gas fields in Syria as well as in Iraq, we have by now enough evidence to be rather sure that the economic base of the „caliphate“ is by no means sustainable...
Why variables?
(1999)
This paper addresses the question of how sentence-internal semantic dependencies are computed? The kind of semantic dependency I am looking at is that between a so called "bound (variable) pronoun" and its binder illustrated in (1), where the dependency is indicated by a connecting line. With all the literature on the topic (see for example Partee 1973, Percus 1998), I assume that this case is the prototype of all semantic dependencies, and therefore any result for this case generalizes to all types of sentence-internal semantic dependencies.
wo assumptions underlie current models of the geographical ranges of perennial plant species: 1. current ranges are in equilibrium with the prevailing climate, and 2. changes are attributable to changes in macroclimatic factors, including tolerance of winter cold, the duration of the growing season, and water stress during the growing season, rather than to biotic interactions. These assumptions allow model parameters to be estimated from current species ranges. Deterioration of growing conditions due to climate change, e.g. more severe drought, will cause local extinction. However, for many plant species, the predicted climate change of higher minimum temperatures and longer growing seasons means, improved growing conditions. Biogeographical models may under some circumstances predict that a species will become locally extinct, despite improved growing conditions, because they are based on an assumption of equilibrium and this forces the species range to match the species-specific macroclimatic thresholds. We argue that such model predictions should be rejected unless there is evidence either that competition influences the position of the range margins or that a certain physiological mechanism associated with the apparent improvement in growing conditions negatively affects the species performance. We illustrate how a process-based vegetation model can be used to ascertain whether such a physiological cause exists. To avoid potential modelling errors of this type, we propose a method that constrains the scenario predictions of the envelope models by changing the geographical distribution of the dominant plant functional type. Consistent modelling results are very important for evaluating how changes in species areas affect local functional trait diversity and hence ecosystem functioning and resilience, and for inferring the implications for conservation management in the face of climate change.
Previous reports of improved oral reading performance for dyslexic children but not for regular readers when between-letter spacing was enlarged led to the proposal of a dyslexia-specific deficit in visual crowding. However, it is in this context also critical to understand how letter spacing affects visual word recognition and reading in unimpaired readers. Adopting an individual differences approach, the present study, accordingly, examined whether wider letter spacing improves reading performance also for non-impaired adults during silent reading and whether there is an association between letter spacing and crowding sensitivity. We report eye movement data of 24 German students who silently read texts presented either with normal or wider letter spacing. Foveal and parafoveal crowding sensitivity were estimated using two independent tests. Wider spacing reduced first fixation durations, gaze durations, and total fixation time for all participants, with slower readers showing stronger effects. However, wider letter spacing also reduced skipping probabilities and elicited more fixations, especially for faster readers. In terms of words read per minute, wider letter spacing did not provide a benefit, and faster readers in particular were slowed down. Neither foveal nor parafoveal crowding sensitivity correlated with the observed letter-spacing effects. In conclusion, wide letter spacing reduces single word processing time in typically developed readers during silent reading, but affects reading rates negatively since more words must be fixated. We tentatively propose that wider letter spacing reinforces serial letter processing in slower readers, but disrupts parallel processing of letter chunks in faster readers. These effects of letter spacing do not seem to be mediated by individual differences in crowding sensitivity.
Several studies suggested that transcription factor (TF) binding to DNA may be impaired or enhanced by DNA methylation. We present MeDeMo, a toolbox for TF motif analysis that combines information about DNA methylation with models capturing intra-motif dependencies. In a large-scale study using ChIP-seq data for 335 TFs, we identify novel TFs that are affected by DNA methylation. Overall, we find that CpG methylation decreases the likelihood of binding for the majority of TFs. For a considerable subset of TFs, we show that intra-motif dependencies are pivotal for accurately modelling the impact of DNA methylation on TF binding.
Williams, Paul H. ; Altanchimeg, Dorjsuren ; Byvaltsev, Alexandr ; De Jonghe, Roland ; Jaffar, Saleem ; Japoshvili, George ; Kahono, Sih ; Liang, Huan ; Mei, Maurizio ; Monfared, Alireza ; Nidup, Tshering ; Raina, Rifat ; Renfordt, Zongxin ; Thanoosing, Chawatat ; Zhao, Yanhui ; Orr, Michael C.
Species are often presumed to be apparent in nature, but in practice they may be difficult to recognise, especially when viewed across continents rather than within a single site. Coalescent-based Poisson-tree-process (PTP) models applied to fast-evolving genes promise one quantitative criterion for recognising species, complete with the estimates of uncertainty that are required of a scientific method. Such methods face challenges especially in discerning between widespread polytypic species and complexes of closely related, restricted-range species. In particular, ‘over-sampling’ of many closely related individuals within one species could risk causing groups of less closely-related individuals within other species appearing relatively more distinct and consequently could risk them being interpreted falsely as separate species. Some of the most persistent taxonomic problems among bumblebees (genus Bombus Latreille, 1802) are within the subgenus Melanobombus von Dalla Torre, 1880. For a global revision of Melanobombus species, we use COI barcodes and seek to reduce the risk from localised over-sampling by filtering the data to include only unique haplotypes. Unique haplotypes give more conservative results than unfiltered data, but still increase the number of species in comparison with recent morphological treatments. After integrative assessment of COI coalescents in comparison with morphological groups, the number of accepted species shows a non-linear increase with sample size that plateaus to an increase of 47% (to 25 species) compared with a previous estimate (of 17) based on morphology alone. For the most widespread and variable species-complexes, our revised species improve the match to the patterns expected of species, both for genetic divergence-with-distance and for sympatry, leading to three main inferences. (1) The particularly widespread polytypic Bombus sichelii Radoszkowski, 1859, is a single species. (2) We detect two candidates for species within previous broad concepts of each of the former B. lapidarius (Linnaeus, 1758), B. miniatus Bingham, 1897, and B. rufofasciatus Smith, 1852. Within B. lapidarius s. lat. we find insufficient evidence to corroborate the candidate species, with no coalescent or morphological support for a recent claim for a separate species, B. bisiculus Lecocq, Biella, Martinet & Rasmont, 2019 described from southern Italy, but rather we find a weak and uncorroborated coalescent for a different and much broader group of samples from across southeastern Europe but excluding Turkey. Within the former broad concepts of B. miniatus s. lat. and B. rufofasciatus s. lat. the coalescent evidence is stronger and subtle evidence from morphology corroborates recognising B. miniatus s. str. and B. eurythorax Wang, 1892 stat. rev. as separate species as well as B. rufofasciatus s. str. and B. prshewalskyi Morawitz, 1880 stat. rev. as separate species. (3) Our coalescent and morphological results ‘split’ more clearly what has long been interpreted as a single polytypic B. keriensis Morawitz, 1887, s. lat., by supporting novel concepts of the restricted-range species: B. alagesianus Reinig, 1930 stat. rev., B. incertoides Vogt, 1911 stat. rev., B. keriensis s. str., B. qilianensis sp. nov., B. separandus Vogt, 1909 stat. rev., and B. tibeticus sp. nov. A lectotype is designated for the name B. keriensis and a neotype is designated for the name B. alagesianus. We estimate the phylogeny of Melanobombus species by including three slower-evolving genes to provide more evidence for deeper relationships, to estimate the time calibration of this phylogeny, and to estimate ancestral distributions, all within a Bayesian framework. We provide the first keys for identifying all of the species of Melanobombus.
The wide-area deployment of WiFi hot spots challenges IP access providers. While new profit models are sought after by them, profitability as well as logistics for large-scale deployment of 802.11 wireless technology are still to be proven. Expenditure for hardware, locations, maintenance, connectivity, marketing, billing and customer care must be considered. Even for large carriers with infrastructure, the deployment of a large-scale WiFi infrastructure may be risky. This paper proposes a multi-level scheme for hot spot distribution and customer acquisition that reduces financial risk, cost of marketing and cost of maintenance for the large-scale deployment of WiFi hot spots.
We study the Wigner function for massive spin-1/2 fermions in electromagnetic fields. The Wigner function is analytically solved in five cases when electromagnetic fields are constants. For a general space-time dependent field configuration, we use the method of semi-classical expansion and solved the Wigner function at linear order in the Planck's constant. At the same order, we obtained a generalized Boltzmann equation for particle distribution, and a generalized BMT equation for spin polarization. Using the Wigner function, we calculated some physical quantities in a thermal equilibrium system.
This paper provides a theoretical assessment of gestures in the context of authoring image-related hypertexts by example of the museum information system WikiNect. To this end, a first implementation of gestural writing based on image schemata is provided (Lakoff in Women, fire, and dangerous things: what categories reveal about the mind. University of Chicago Press, Chicago, 1987). Gestural writing is defined as a sort of coding in which propositions are only expressed by means of gestures. In this respect, it is shown that image schemata allow for bridging between natural language predicates and gestural manifestations. Further, it is demonstrated that gestural writing primarily focuses on the perceptual level of image descriptions (Hollink et al. in Int J Hum Comput Stud 61(5):601–626, 2004). By exploring the metaphorical potential of image schemata, it is finally illustrated how to extend the expressiveness of gestural writing in order to reach the conceptual level of image descriptions. In this context, the paper paves the way for implementing museum information systems like WikiNect as systems of kinetic hypertext authoring based on full-fledged gestural writing.
The paper presents a study which was based on the hypothesis that wikis that are initiated bottom up by students might be used more deliberately than wikis which are introduced top down by teachers. Therefore it examines the specific effects observed in nine different wiki projects at the university of Frankfurt ranging from student wiki projects up to wikis used in seminars and as information tool for institutions.
This paper investigates whether exchanging the Social Security delayed retirement credit, currently paid as an increase in lifetime annuity benefits, for a lump sum would induce later claiming and additional work. We show that people would voluntarily claim about half a year later if the lump sum were paid for claiming any time after the Early Retirement Age, and about two-thirds of a year later if the lump sum were paid only for those claiming after their Full Retirement Age. Overall, people will work one-third to one-half of the additional months, compared to the status quo. Those who would currently claim at the youngest ages are likely to be most responsive to the offer of a lump sum benefit.
Harapan, Harapan ; Mudatsir, Mudatsir ; Yufika, Amanda ; Nawawi, Yusuf ; Wahyuniati, Nur ; Anwar, Samsul ; Yusri, Fitria ; Haryanti, Novi ; Wijayanti, Nanda Putri ; Rizal, Rizal ; Fitriani, Devi ; Maulida, Nurul Fadhliati ; Syahriza, Muhammad ; Ikram, Ikram ; Fandoko, Try Purwo ; Syahadah, Muniati ; Asrizal, Febrivan Wahyu ; Jamil, Kurnia ; Rajamoorthy, Yogambigai ; Wagner, Abram Luther ; Groneberg, Jan David Alexander ; Kuch, Ulrich ; Müller, Ruth ; Sasmono, R. Tedjo ; Imrie, Allison
One of the crucial steps during trials for Zika and other vaccines is to recruit participants and to understand how participants’ attitudes and sociodemographic characteristics affect willingness to participate (WTP). This study was conducted to assess WTP, its explanatory variables, and the impact of financial compensation on WTP in Indonesia. A health facility-based cross-sectional study was conducted in eleven regencies in the Aceh and West Sumatra provinces of Indonesia. Participants were recruited via a convenience sampling method and were interviewed. The associations between explanatory variables and WTP were assessed using a two-step logistic regression analysis. A total of 1,102 parents were approached, and of these 956 (86.8%) completed the interview and were included in analysis. Of those, 144 (15.1%) were willing to participate in a Zika vaccine trial without a financial compensation. In the multivariate analysis, WTP was tied to an age of more than 50 years old, compared to 20–29 years (odds ratio (OR): 5.0; 95% confidence interval (CI): 2.37–10.53), to being female (OR: 2.20; 95% CI: 1.11–4.37), and to having heard about Zika (OR: 2.41; 95% CI: 1.59–3.65). Participants’ WTP increased gradually with higher financial compensation. The rate of WTP increased to 62.3% at the highest offer (US$ 350.4), and those who were still unwilling to participate (37.7%) had a poorer attitude towards childhood vaccination. This study highlights that pre-existing knowledge about Zika and attitudes towards childhood vaccination are important in determining community members being willing to participate in a vaccine trial. Financial incentives are still an important factor to enhance participant recruitment during a vaccine trial.
There are many aspects of Haas' life and experiences in India which deserve greater attention. I would like to refer briefly only to his attempts as a litterateur to come to terms with 'India' as presented in his autobiographical recollection and to some comparative cultural reflections in his essays. Like all reconstructions his autobiographical recollection of India is also a construct in which the site of India as a place of exile is justified by an achieved awareness between conscious individual choice and inevitability. An individual acts out a personal history, the prefiguration of which he only becomes aware of in the form of a subsequent epiphanic realization. Given Haas' literary background, it is not surprising that this is articulated through a literary association.
Chern numbers can be calculated within a frame of vortex fields related to phase conventions of a wave function. In a band protected by gaps the Chern number is equivalent to the total number of flux carrying vortices. In the presence of topological defects like Dirac cones this method becomes problematic, in particular if they lack a well-defined winding number. We develop a scheme to include topological defects into the vortex field frame. A winding number is determined by the behavior of the phase in reciprocal space when encircling the defect's contact point. To address the possible lack of a winding number we utilize a more general concept of winding vectors. We demonstrate the usefulness of this ansatz on Dirac cones generated from bands of the Hofstadter model.
Chern numbers can be calculated within a frame of vortex fields related to phase conventions of a wave function. In a band protected by gaps the Chern number is equivalent to the total number of flux carrying vortices. In the presence of topological defects like Dirac cones this method becomes problematic, in particular if they lack a well-defined winding number. We develop a scheme to include topological defects into the vortex field frame. A winding number is determined by the behavior of the phase in reciprocal space when encircling the defect's contact point. To address the possible lack of a winding number we utilize a more general concept of winding vectors. We demonstrate the usefulness of this ansatz on Dirac cones generated from bands of the Hofstadter model.
Chern numbers can be calculated within a frame of vortex fields related to phase conventions of a wave function. In a band protected by gaps the Chern number is equivalent to the total number of flux carrying vortices. In the presence of topological defects like Dirac cones this method becomes problematic, in particular if they lack a well-defined winding number. We develop a scheme to include topological defects into the vortex field frame. A winding number is determined by the behavior of the phase in reciprocal space when encircling the defect's contact point. To address the possible lack of a winding number we utilize a more general concept of winding vectors. We demonstrate the usefulness of this ansatz on Dirac cones generated from bands of the Hofstadter model.
Over the past fifteen years, Weaver Press has published seven anthologies of some one hundred short stories giving voice to new and established Zimbabwean writers. In Windows into Zimbabwe Franziska Kramer and Jürgen Kramer have selected from these anthologies twenty-three stories, which they consider the best or most representative of a particular period in the Zimbabwean narrative since 1980. They present the stories within sections which frame certain themes such as Independence, Gukurahundi, Land, Gender Relations, Money Matters, Social Relations, Exile and Resilience. For the general reader, Windows into Zimbabwe contains some wonderful stories rich in insight, perception, nuance and humour. Writers such as Charles Mungoshi, Petina Gappah, NoViolet Bulawayo, Valerie Tagwira and Shimmer Chinodya are included as well as relative newcomers with new perceptions and fresh voices. The compilers have also provided an introductory overview casting light on the relationship between fiction and society; and for teachers(in schools, colleges and universities) each story is accompanied by explanatory notes, questions and study tasks to further the reader's understanding. Windows into Zimbabwe will positively deepen your appreciation of the country and its people.
Ebola virus (EBOV) infection causes a high death toll, killing a high proportion of EBOV-infected patients within 7 days. Comprehensive data on EBOV infection are fragmented, hampering efforts in developing therapeutics and vaccines against EBOV. Under this circumstance, mathematical models become valuable resources to explore potential controlling strategies. In this paper, we employed experimental data of EBOV-infected nonhuman primates (NHPs) to construct a mathematical framework for determining windows of opportunity for treatment and vaccination. Considering a prophylactic vaccine based on recombinant vesicular stomatitis virus expressing the EBOV glycoprotein (rVSV-EBOV), vaccination could be protective if a subject is vaccinated during a period from one week to four months before infection. For the case of a therapeutic vaccine based on monoclonal antibodies (mAbs), a single dose might resolve the invasive EBOV replication even if it was administrated as late as four days after infection. Our mathematical models can be used as building blocks for evaluating therapeutic and vaccine modalities as well as for evaluating public health intervention strategies in outbreaks. Future laborator experiments will help to validate and refine the estimates of the windows of opportunity proposed here.
Narin Sontigun ; Kabkaew L. Sukontason ; Zajac, Barbara Karolina ; Zehner, Richard ; Kom Sukontason ; Anchalee Wannasan ; Amendt, Jens
Background: Correct species identification of blow flies is a crucial step for understanding their biology, which can be used not only for designing fly control programs, but also to determine the minimum time since death. Identification techniques are usually based on morphological and molecular characters. However, the use of classical morphology requires experienced entomologists for correct identification; while molecular techniques rely on a sound laboratory expertise and remain ambiguous for certain taxa. Landmark-based geometric morphometric analysis of insect wings has been extensively applied in species identification. However, few wing morphometric analyses of blow fly species have been published.
Methods: We applied a landmark-based geometric morphometric analysis of wings for species identification of 12 medically and forensically important blow fly species of Thailand. Nineteen landmarks of each right wing of 372 specimens were digitised. Variation in wing size and wing shape was analysed and evaluated for allometric effects. The latter confirmed the influence of size on the shape differences between species and sexes. Wing shape variation among genera and species were analysed using canonical variates analysis followed by a cross-validation test.
Results: Wing size was not suitable for species discrimination, whereas wing shape can be a useful tool to separate taxa on both, genus and species level depending on the analysed taxa. It appeared to be highly reliable, especially for classifying Chrysomya species, but less robust for a species discrimination in the genera Lucilia and Hemipyrellia. Allometry did not affect species separation but had an impact on sexual shape dimorphism.
Conclusions: A landmark-based geometric morphometric analysis of wings is a useful additional method for species discrimination. It is a simple, reliable and inexpensive method, but it can be time-consuming locating the landmarks for a large scale study and requires non-damaged wings for analysis.
We radio-tracked two male and one female Virginia northern flying squirrels (Glaucomys sabrinus fuscus) in the Allegheny Mountains of West Virginia at Snowshoe Mountain Resort, in winter 2003 and Canaan Valley National Wildlife Refuge in winter 2004, respectively, to document winter home range and habitat use in or near ski areas. Male home range size in the winter was larger than that reported for males during summer and fall, whereas the female home range we observed was smaller than those reported for summer and fall. However, winter habitat use was similar to summer and fall habitat use reported in other studies. Virginia northern flying squirrels foraged and denned in both red spruce (Picea rubens)-dominated forests and northern hardwood forests; however, selection of red spruce-dominated forests and open areas was greater than expected based on availability. Use of northern hardwood forest occurred less than expected based on availability. Male squirrels denned near, and routinely crossed, downhill ski slopes and unimproved roads during foraging bouts, whereas the female approached, but did not cross forest edges onto roads or trails.
Winter's law again
(2007)
Since I discussed the scholarly literature on Winter’s law twenty years ago (1988), several important articles on the subject have appeared (Young 1990, Campanile 1994, Matasovic 1995, Derksen 2002, Dybo 2002, Patri 2005, Derksen 2007). As the law evidently continues to be controversial, it is important to look into the nature of the evidence and counter-evidence which is adduced. It appears that doubts about Winter’s law are largely the result of four types of misunderstanding.
The northern plains of Saudi Arabia are an area of approximately 231,000 km2, or roughly equivalent to the size of the whole of the United Kingdom. During previous ABBA Surveys in this area in late winter and spring significant numbers of wintering species such as Dotterel Charadrius morinellus, sandgrouse Pterocles sps and eagles and vultures have been recorded, as well as the threatened Sociable Plover Vanellus gregarius. The main objective of ABBA Survey 40 (30 January - 28 February 2009) was to assess wintering populations of these birds in northern Arabia through sampling methods. In all 21 timed walked censuses in the early morning and 25 driven transect counts (over a total distance of 1511 km) were carried out. Unfortunately most of the region had suffered a severe drought over an extended period, perhaps the previous ten years or longer, and in most of the survey area there had been no rain at all during the winter/spring period of 2008/2009. This lack of rain had resulted in a complete lack of green vegetation in most of the western part of the area studied. Consequently the census results showed low species diversity and small populations.
This article provides an overview and critical assessment of WIPO ALERT. It locates this initiative in the broader context of transnational IP enforcement schemes on the Internet. These initiatives are classified into two categories according to their point of attachment and geographical effect. Whereas source-related measures (e.g. website takedowns) tend to have a transnational and possibly even a global effect, recipient-related measures (e.g. website and ad blockings) typically mirror the territorially fragmented IPR landscape. This fragmentation is where WIPO ALERT comes into play. It can be understood as a matching service which interconnects holders of information about copyright infringing websites (“Authorized Contributors”) and actors of the online ad industry who want to avoid these outlets (“Authorized Users”). The critical assessment of WIPO ALERT calls for more transparency and the establishment of uniform substantive and procedural standards that have to be met if a new “site of concern” is added to the global ad blacklist.
The influence and power of some OECD states is under threat but China appears to remain astonishingly flexible, economically potent, and politically strong. How accurate is this view? To answer this question, major aspects of Chinese economic regulation that were adopted in the country’s progress towards capitalist modernization are examined. The analysis requires a historical reconstruction of how China changed the way it intervenes economically and politically, especially with regard to the institutions of the central state. Such a reconstruction reveals that, since the 1990s, the central state has indeed increased its steering capacities. These capacities have a distinctive basis that includes acceptance of a state-centered approach, idiosyncratic innovation policies taking place in the "shadow" of the state’s hierarchy, and the ongoing influence of the communist party. An all-embracing controlling power is, however, not detectable. What does exist in China’s competition-driven system of “statecapitalist” regulation, is a set of limits on the state’s capacity to govern.
In 1905, the managing editor of the Jewish Encyclopedia, Isidore Singer (1859–1939), published an article in the journal Ost und West from a "bird’s eye perspective on the development of American Jewry in the last 250 years." In this historical overview, Singer eventually attested that Jewish scholarship in America had an "absolute dependency on the European motherland." This judgment was based on his disapproving view of the two American rabbinical seminaries that existed at that time. According to Singer, there were still no scholars at the Hebrew Union College (HUC) in Cincinnati of the "already American[-born] generation of Israel." In fact, Singer’s observation was appropriate because it applied to the Jewish Theological Seminary of America (JTSA) in New York as much as to the HUC.3 Despite the history of Jewish settlement in America, around 1900 there was still no native Jewish scholarship in America. The scene was dominated by scholars educated in Europe, who often came with broken English and a strict academic sense of mission. In 1903, Kaufmann Kohler (1843–1926), born in Bavaria and trained at German universities, was chosen as the president of HUC. And a year earlier, Solomon Schechter (1847–1915) had been called to the JTSA in New York as its new president. ...
Witch Girl
(2015)
This is modern Lusaka, Zambia, where the line between magic and religion is blurred, the arcane and the mundane muddle and nothing is what it seems. Luse is a sharp street child combing the gang-ridden city in a desperate search for Doctor Georgia Shapiro who she hopes can offer her a way back into her once-bright past. The doctor is trying to unravel the mystery of a friend's sudden death while attending to the AIDS crisis laying waste to the country around her. Meanwhile The Blood Of Christ Church and its enigmatic leader Priestess Selena Clark gain popularity with their murky promises of salvation and violent clandestine rituals. A small silver box links them in ways they cannot foretell. It will force Luse and Georgia to question who they trust, who they are and for whom they fight. Tanvi Bush's Witch girl is a crime thriller that juggles the past and the present effortlessly, blending AIDS activism, witchcraft, religious extremism and romance to create a well-paced narrative. Luse is so feisty, charming and resourceful that you'll miss her after you finish the book.
This is a comparative ethnographic study of witchcraft and associated violence between the kingdoms of Kom and Venda in Cameroon and South Africa respectively. The book shows why despite its prevalence in both societies, witchcraft does not lead to open violence in Kom, while such large-scale violence is commonplace in Venda. It reveals that this difference can be explained by factors such as the variations in local ideas on witches, differences in the role of traditional authorities, and various state interventions on witchcraft matters. The book demonstrates, through a rich collection of detailed cases, that contrary to anthropological theory that views witchcraft as a mechanism for the expression and resolution of social tensions and conflicts, witchcraft may at times become a disturbance of amicable social relations. Witchcraft accusations may occur in a context where strained social relations have not preceded them. The knowledge and experience that people have about witchcraft is sufficient to trigger an accusation and a violent reaction. Different forms of witchcraft account for variations in witchcraft attributions and accusations. This comparison provides a valuable contribution to ongoing witchcraft policy discourse amid widespread citizen anxiety over witchcraft, and the increasing call on the post-colonial state to intervene and protect its citizens against occult aggression.
This book is largely the personal account by Patrick Mbunwe Samba, of how life in his home village of Binshua has been permeated throughout by belief in witchcraft. The book not only provides a historical account informed by his reminiscences of his childhood, it shows as well that even today, belief in witchcraft is very widespread. Witchcraft exerts a profound influence on society in Binshua and in Cameroon in general. The book also provides accounts of the experiences of others, some of them very recent, and gives examples of what injustices and suffering can be caused by the notion that any misfortune must have been caused by witchcraft. For the overwhelming majority of people in village communities such as Binshua, Samba argues, anything not immediately understandable is witchcraft - which is synonymous with mystery. Many educated Africans, too, revert to such traditional attitudes in stressful situations. It may be thought surprising that in spite of the impact of Christianity, Western culture and the improved level of education, the majority of people still believe in witchcraft, and that this phenomenon not only persists but is actually increasing. The book perplexes and challenges by avoiding to provide simple answers to the question whether which witchcraft is real or imagined.
Atkinson, Andrew ; Zwahlen, Marcel ; Barger, Diana ; d’Arminio Monforte, Antonella ; Wit, Stephane de ; Girardi, Enrico ; Svedhem, Veronica ; Morlat, Philippe ; Mussini, Cristina ; Noguera-Julian, Antoni ; Stephan, Christoph ; Touloumi, Giota ; Kirk, Ole ; Mocroft, Amanda ; Reiss, Peter ; Miró, Jose Maria ; Carpenter, James R. ; Furrer, Hansjakob
Background: Using data from the COHERE collaboration, we investigated whether primary prophylaxis for pneumocystis pneumonia (PcP) might be withheld in all patients on antiretroviral therapy (ART) with suppressed plasma human immunodeficiency virus (HIV) RNA (≤400 copies/mL), irrespective of CD4 count.
Methods: We implemented an established causal inference approach whereby observational data are used to emulate a randomized trial. Patients taking PcP prophylaxis were eligible for the emulated trial if their CD4 count was ≤200 cells/µL in line with existing recommendations. We compared the following 2 strategies for stopping prophylaxis: (1) when CD4 count was >200 cells/µL for >3 months or (2) when the patient was virologically suppressed (2 consecutive HIV RNA ≤400 copies/mL). Patients were artificially censored if they did not comply with these stopping rules. We estimated the risk of primary PcP in patients on ART, using the hazard ratio (HR) to compare the stopping strategies by fitting a pooled logistic model, including inverse probability weights to adjust for the selection bias introduced by the artificial censoring.
Results: A total of 4813 patients (10 324 person-years) complied with eligibility conditions for the emulated trial. With primary PcP diagnosis as an endpoint, the adjusted HR (aHR) indicated a slightly lower, but not statistically significant, different risk for the strategy based on viral suppression alone compared with the existing guidelines (aHR, .8; 95% confidence interval, .6–1.1; P = .2).
Conclusions: This study suggests that primary PcP prophylaxis might be safely withheld in confirmed virologically suppressed patients on ART, regardless of their CD4 count.
Within the Walls of Hell
(2011)
The Land of Eternal Discomfort is a place where no one wants to go. It is hot and dirty. One is sure to experience depression once there and sleep is a luxury no longer attainable in that place. Unbelievable though it may seem one enters the Land of Eternal Discomfort by choice. It is a place destined for those who did not live a righteous life according to the Creator. The kind of life one lives down below determines where they go thereafter. For the seven characters in this play, the love of power and the hatred for those different and inferior to themselves leads them to choose a life of luxury gained through deceit, theft, adultery and murder. Against all the Creator's commands, they chose to live lives of self-gratification ignoring their obligations to their fellow man. The choice they made was for their lives down there but they will forever live with the consequences in their lives thereafter. Life down there does not last forever and the characters are destined to meet the Messenger at which time the choice will have already been made. When you finally meet the Messenger, pray that he is ushering you into the Land of Eternal Happiness because in the other place you are doomed forever. In the Land of Eternal Discomfort the gate can only open to let someone in. It cannot open to let anyone out. Once you are in there you can never get out again.