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Global investment in biomedical research has grown significantly over the last decades, reaching approximately a quarter of a trillion US dollars in 2010. However, not all of this investment is distributed evenly by gender. It follows, arguably, that scarce research resources may not be optimally invested (by either not supporting the best science or by failing to investigate topics that benefit women and men equitably). Women across the world tend to be significantly underrepresented in research both as researchers and research participants, receive less research funding, and appear less frequently than men as authors on research publications. There is also some evidence that women are relatively disadvantaged as the beneficiaries of research, in terms of its health, societal and economic impacts. Historical gender biases may have created a path dependency that means that the research system and the impacts of research are biased towards male researchers and male beneficiaries, making it inherently difficult (though not impossible) to eliminate gender bias. In this commentary, we – a group of scholars and practitioners from Africa, America, Asia and Europe – argue that gender-sensitive research impact assessment could become a force for good in moving science policy and practice towards gender equity. Research impact assessment is the multidisciplinary field of scientific inquiry that examines the research process to maximise scientific, societal and economic returns on investment in research. It encompasses many theoretical and methodological approaches that can be used to investigate gender bias and recommend actions for change to maximise research impact. We offer a set of recommendations to research funders, research institutions and research evaluators who conduct impact assessment on how to include and strengthen analysis of gender equity in research impact assessment and issue a global call for action.
La littérature comparée est aujourd’hui solidement implantée dans les cursus universitaires français. Elle a engagé depuis le tournant des années 2000 une série de bilans et de réflexions sur son histoire, conditions d’un renouvellement pour affronter les nouveaux défis contemporains, notamment celui du numérique et de la mondialisation. On peut difficilement, de fait, comprendre sa place dans l’enseignement et la recherche français sans rappeler, même très brièvement, l’histoire de sa constitution en pratique de la critique et en discipline universitaire, et sans tenir compte des cadres institutionnels au sein desquels elle s’exerce. Cette présentation commencera donc par là, avant d’esquisser un état des lieux et des perspectives pour l’avenir.
Systemic lupus erythematosus (SLE) is a chronic disease characterized by progressive tissue damage. In recent decades, novel treatments have greatly extended the life span of SLE patients. This creates a high demand for identifying the overarching symptoms associated with SLE and developing therapies that improve their life quality under chronic care. We hypothesized that SLE patients would present dysphonic symptoms. Given that voice disorders can reduce life quality, identifying a potential SLE-related dysphonia could be relevant for the appraisal and management of this disease. We measured objective vocal parameters and perceived vocal quality with the GRBAS (Grade, Roughness, Breathiness, Asthenia, Strain) scale in SLE patients and compared them to matched healthy controls. SLE patients also filled a questionnaire reporting perceived vocal deficits. SLE patients had significantly lower vocal intensity and harmonics to noise ratio, as well as increased jitter and shimmer. All subjective parameters of the GRBAS scale were significantly abnormal in SLE patients. Additionally, the vast majority of SLE patients (29/36) reported at least one perceived vocal deficit, with the most prevalent deficits being vocal fatigue (19/36) and hoarseness (17/36). Self-reported voice deficits were highly correlated with altered GRBAS scores. Additionally, tissue damage scores in different organ systems correlated with dysphonic symptoms, suggesting that some features of SLE-related dysphonia are due to tissue damage. Our results show that a large fraction of SLE patients suffers from perceivable dysphonia and may benefit from voice therapy in order to improve quality of life.
Quantification of spatially and temporally resolved water flows and water storage variations for all land areas of the globe is required to assess water resources, water scarcity and flood hazards, and to understand the Earth system. This quantification is done with the help of global hydrological models (GHMs). What are the challenges and prospects in the development and application of GHMs? Seven important challenges are presented. (1) Data scarcity makes quantification of human water use difficult even though significant progress has been achieved in the last decade. (2) Uncertainty of meteorological input data strongly affects model outputs. (3) The reaction of vegetation to changing climate and CO2 concentrations is uncertain and not taken into account in most GHMs that serve to estimate climate change impacts. (4) Reasons for discrepant responses of GHMs to changing climate have yet to be identified. (5) More accurate estimates of monthly time series of water availability and use are needed to provide good indicators of water scarcity. (6) Integration of gradient-based groundwater modelling into GHMs is necessary for a better simulation of groundwater–surface water interactions and capillary rise. (7) Detection and attribution of human interference with freshwater systems by using GHMs are constrained by data of insufficient quality but also GHM uncertainty itself. Regarding prospects for progress, we propose to decrease the uncertainty of GHM output by making better use of in situ and remotely sensed observations of output variables such as river discharge or total water storage variations by multi-criteria validation, calibration or data assimilation. Finally, we present an initiative that works towards the vision of hyperresolution global hydrological modelling where GHM outputs would be provided at a 1-km resolution with reasonable accuracy.
Am 10. Mai 2014 starb, im hohen Alter von 99 Jahren, Elisabeth Frenzel, geborene Lüttig-Niese, in ihrem letzten Wohnort in Berlin. Zu ihrer Beerdigung erschienen, wie ein lesenswerter Nachruf von David Ensikat im Berliner 'Tagesspiegel' berichtet, 15 Menschen. Die Pastorin stellte die Trauerfeier unter das Thema des schwierigen Erbes, der Schuld und den Möglichkeiten der Vergebung. Das war vielleicht nicht im Sinne der Verstorbenen, aber im Sinne der Lebensgeschichte der Verstorbenen sicherlich ein sehr guter Ansatz, um sich von Elisabeth Frenzel zu verabschieden.
Nachruf auf Eberhard Lämmert
(2015)
Den Erzähler Thomas Mann nannte der Germanist Eberhard Lämmert 'buchtenreich'. Auch sein eigenes OEuvre verdient indes diese Qualifikation: Es ist - natürlich - eines aus zahllosen literaturwissenschaftlichen Büchern, Aufsätzen, Vorworten, Nachbemerkungen, aus offiziellen Reden, öffentlichen Statements, Aufrufen, Gutachten und und und, die Themen sind vielfältig, die Beziehungen zwischen ihnen komplex.
The world in a 'Zeitschrift'
(2015)
The relaunching of the Jahrbuch 'Komparatistik' in 2015 takes place at a time of ferment in comparative literary studies, as a discipline long focused primarily on Western Europe seeks to reconsider its position in a global landscape, and in the process to rethink the contours of European literature itself. Here I would like to discuss one new manifestation of this rethinking: the founding of the 'Journal of World Literature', which will be debuting in 2016. Published in Amsterdam by Brill, with its managing editors located in Leuven and in Göttingen, the 'JWL' represents a European initiative in comparative and world literary studies, and the journal has a global presence as well. It is overseen by an international board of editors (myself among them), and it has an association with the Institute for World Literature, a Harvard-based program supported by five dozen institutions around the world, which will be responsible for one of its quarterly issues each year. Global in outlook and outreach, the 'JWL' can equally be thought of as carrying on an originally German project: to embody the potentially vast field of comparative and world literature within the pages available in a scholarly journal. To this end, very different approaches were tried in the last quarter of the nineteenth century by two foundational journals: the 'Acta Comparationis Litterarum Universarum', published in Cluj from 1877-88 by the Transylvanian scholars Hugo Meltzl and Sámuel Brassai, and the 'Zeitschrift für vergleichende Litteraturgeschichte', founded in 1886, published in Berlin under the editorship of Max Koch. Probably the very first journals in the field – the French 'Revue de littérature comparée', for example, dates only from 1921 – these pioneering journals divided up the literary territory in very different ways. Meltzl and Brassai’s 'Acta' reflected an idealistic globalism grounded in a radical multilingualism, whereas Koch opted for a more pragmatic but markedly nationalistic conception of the field. The new 'Journal of World Literature' will need to draw on the strengths of each approach even as its editors seek to avoid the pitfalls of both.
The venture capital industry holds relevance for entrepreneurs looking for money to finance an innovative project, investors seeking to make money by investing in entrepreneurial firms and governments trying to promote innovation and entrepreneurship. Venture capital investment could facilitate innovation and thus a better economy.
Venture capital has enabled the U.S. to support its entrepreneurial talent by turning ideas into world-famous products and services, building companies from mere business plans to mature and powerful organizations. Three of the five largest U.S. public companies by market capitalization – Apple, Google and Microsoft – received most of their early external funding from venture capital. Having its ups and downs, venture capital investment in the U.S. expanded from virtually zero in the mid-1970s to $8 billion in 1995 and $49.3 billion in 2014. Venture backed companies have been a prime driver of economic growth in the U.S.Across the pacific, venture capital investment in China has grown out of the transition from a centrally planned economy to a free market economy over the past three decades, becoming an important pillar supporting China’s innovation system. In 2015, a total of 2,824 venture capital investment deals provided an aggregate investment of $36.9 billion. Venture capital has long been a hot topic in China’s capital market, particularly since the government decided to boost “mass entrepreneurship and innovation” in 2014.
In the U.S., most venture capital firms are organized as limited partnerships, with the venture capitalists being general partners and the investors limited partners. Studies have shown that investors choose to invest through venture funds as an intermediary rather than placing their investments directly with the entrepreneurs; because of the high risk nature of the entrepreneur’s business, it is hard for them to get bank loans or direct equity investments. Conflicts may also arise, however, between the venture capitalists acting as agents and the investors as principals.5 This agency problem maybe particularly severe, since venture capital provides money for businesses with high potential and high risk, although the limited partnership has certain merits and is still most commonly chosen as the business form for venture capital funds.6 At the same time, the fact that general partners have total control of the partnership business necessitates that the agency problem is addressed by legal rules, contracts and other mechanisms.
Meanwhile, despite the rapid growth of venture capital investments in China, little attention has been paid to the organizational form of venture capital funds. In contrast to the U.S., most Chinese venture funds have been structured as corporations. One may argue that it was due to legislative reasons: that the limited partnership was not recognized by Chinese law when venture capital first appeared in China. However, after adopted a chapter was adopted in the Partnership Enterprise Law (PEL) governing limited partnerships in 2007, most of the venture funds abided by their choice, while those opting for the limited partnership have encountered difficulties: the limited partners are having trouble trusting the general partners with their money and are therefore interfering with the operation of the partnership business, which may lead to dissolution of the partnership.
This thesis applies transaction cost theory to explain the benefits and costs of choosing the limited partnership as a business form in the special context of venture capital investments, showing that the potential agency conflict between the general partners and the limited partners have been mitigated by legal and other mechanismsin the United States, and that the U.S. investors could therefore exploit the merit of the limited partnership form in venture capital financing. In China, investors have different answers to the agency problem. Similarly to the situation in the U.S., Chinese partners also employ contract terms to deal with agency problems, and the legislators enact laws that aim at regulating the limited partnership form; some legislation was even transplanted from the U.S., such as that part of the PEL which governs limited partnerships. It seems, then, that similar mechanisms that deal with agency problems also exist in China. However, given the unique history of the development of China’s innovation system and venture capital market, the effectiveness of these constraints is questionable. Chinese venture capital investors have therefore characteristically behaved differently to U.S. investors. Rather than relying on these questionable mechanisms, Chinese investors as well as the Chinese government have developed different approaches to addressing these agency problems.
During the 1970s, industrial countries, including the US and continental Europa, experienced a combination of slow productivity growth and high unemplyoment. Subsequent research has shown that the standard model of unemployment actually gives counterfactual predictions. Motivated by the observation that the 1970s were also characterized by high and rising inflation, Tesfaselassie and Wolters examine the effect of growth on unemployment in the presence of nominal price rigidity.
The authors demonstrate that the effect of growth on unemployment may be positive or negative. Faster growth leads to lower unemployment if the rate of inflation is high enough. There is a threshold level of inflation below which faster growth leads to higher unemployment and above which faster growth leads to lower unemployment. The threshold level in turn depends on labor market characteristics, such as hiring efficiency, the job destruction rate, workers' relative bargaining power and the opportunity cost of work.