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Das Vorkommen der seltenen Banater Pfingstrose (Paeonia officinalis L. ssp. banatica (Roch.) Soó) im Codru Moma-Gebirge (Rumänien) wird beschrieben und dessen coenologische Bindung untersucht. Diese Art, die während der letzten Eiszeit auf ihre jetzige disjunkte Verbreitung zurückgedrängt wurde, wird primär in xerothermen Waldgesellschaften angetroffen. Bei dem als bisher "klassisch" geltenden Standort "Binnendünen" handelt es sich wahrscheinlich eher um einen Sekundärstandort.
Although immune checkpoint and targeted therapies offer remarkable benefits for lung cancer treatment, some patients do not qualify for these regimens or do not exhibit consistent benefit. Provided that lung cancer appears to be driven by transforming growth factor beta signaling, we investigated the single drug potency of Pirfenidone, an approved drug for the treatment of lung fibrosis. Five human lung cancer cell lines and one murine line were investigated for transforming growth factor beta inhibition via Pirfenidone by using flow cytometry, In-Cell western analysis, proliferation assays as well as comprehensive analyses of the transcriptome with subsequent bioinformatics analysis. Overall, Pirfenidone induced cell cycle arrest, down-regulated SMAD expression and reduced proliferation in lung cancer. Furthermore, cell stress pathways and pro-apoptotic signaling may be mediated by reduced expression of Survivin. A murine subcutaneous model was used to assess the in vivo drug efficacy of Pirfenidone and showed reduced tumor growth and increased infiltration of T cells and NK cells. This data warrant further clinical evaluation of Pirfenidone with advanced non-small cell lung cancer. The observed in vitro and in vivo effects point to a substantial benefit for using Pirfenidone to reactivate the local immune response and possible application in conjunction with current immunotherapies.
Introduction: Balanced fluid replacement solutions can possibly reduce the risks for electrolyte imbalances, for acid-base imbalances, and thus for renal failure. To assess the intraoperative change of base excess (BE) and chloride in serum after treatment with either a balanced gelatine/electrolyte solution or a non-balanced gelatine/electrolyte solution, a prospective, controlled, randomized, double-blind, dual centre phase III study was conducted in two tertiary care university hospitals in Germany.
Material and methods: 40 patients of both sexes, aged 18 to 90 years, who were scheduled to undergo elective abdominal surgery with assumed intraoperative volume requirement of at least 15 mL/kg body weight gelatine solution were included. Administration of study drug was performed intravenously according to patients need. The trigger for volume replacement was a central venous pressure (CVP) minus positive end-expiratory pressure (PEEP) <10 mmHg (CVP <10 mmHg). The crystalloid:colloid ratio was 1:1 intra- and postoperatively. The targets for volume replacement were a CVP between 10 and 14 mmHg minus PEEP after treatment with vasoactive agent and mean arterial pressure (MAP) > 65 mmHg.
Results: The primary endpoints, intraoperative changes of base excess –2.59 ± 2.25 (median: –2.65) mmol/L (balanced group) and –4.79 ± 2.38 (median: –4.70) mmol/L (non-balanced group)) or serum chloride 2.4 ± 1.9 (median: 3.0) mmol/L and 5.2 ± 3.1 (median: 5.0) mmol/L were significantly different (p = 0.0117 and p = 0.0045, respectively). In both groups (each n = 20) the investigational product administration in terms of volume and infusion rate was comparable throughout the course of the study, i.e. before, during and after surgery.
Discussion: Balanced gelatine solution 4% combined with a balanced electrolyte solution demonstrated significant smaller impact on blood gas analytic parameters in the primary endpoints BE and serum chloride when compared to a non-balanced gelatine solution 4% combined with NaCl 0.9%. No marked treatment differences were observed with respect to haemodynamics, coagulation and renal function.
Trial registration: ClinicalTrials.gov (NCT01515397) and clinicaltrialsregister.eu, EudraCT number 2010-018524-58.
Der Elfenbeinturm hat Fenster. Browserfenster : Wissenschaftskommunikation in sozialen Medien
(2021)
Verpackt in Feedbackschleifen : Einblicke in Digitale Lehrformate des digitalen Sommersemesters
(2021)
Mit der pandemiebedingten Notwendigkeit im Sommersemester ausschließlich digital zu unterrichten ging eine große Frage einher: "Wie komme ich in Kontakt mit unseren Studierenden?" und mehr noch "Wie halte ich diesen Kontakt?" Studierende sind untereinander im Idealfall durch Messenger-Gruppen verbunden, für uns Dozierende bleibt häufig nur ein Kanal: die traditionelle E-Mail. Viele Studierende fragen ihre universitätseigene E-Mail nicht ab oder leiten sie nicht auf eine private E-Mail-Adresse um, was für uns im Grunde bedeutete, dass nur unsere Homepage als sicherer aber eben auch einseitiger Informationskanal zur Verfügung stand. "Wegweiser" zu den neuen digitalen Räumen konnten hier zwar aufgestellt werden, was in diesen Räumen aber angeboten wurde, sollte m.E. interaktiv an die Bedarfe unserer Studierenden angepasst werden. Es brauchte also eigentlich sogar mehr Interaktion als in analogen Lehrveranstaltungen. Daher war für mich bei der Transformation der für das Sommersemester geplanten Lehrveranstaltungen die Integration von Interaktionsmöglichkeiten ein zentraler Aspekt, ein Prozess der selbst aber eben auch ein Trial and Error-Verfahren war, der ohne Feedback ins Leere gelaufen wäre. Nachfolgend möchte ich ein Seminar und drei Formate vorstellen, die Feedback und Interaktion auf unterschiedliche Weise integrieren.
Zwischen November 2003 und Januar 2004 wurde in einem Auwald bei Ingelheim am Rhein mittels Bodenfallen die Weberknechtfauna untersucht. Hierbei konnten insgesamt 1643 Individuen determiniert werden, welche sich auf 6 Arten aus 3 Familien verteilten. Besonders bemerkenswert sind die thermophilen Arten Astrobunus laevipes, Nemastoma dentigerum und Trogulus martensi. Zusätzlich wurden Bodenfallen eines benachbarten Auwaldes von Juni bis Oktober 2004 ausgewertet, die zusätzliche Daten zur Phänologie einiger stenochroner Arten erbrachten. Biotopansprüche, Vikarianzen und Konkurrenzvermeidung werden diskutiert.
From the beginning of May 2005 to September 2007 the pseudoscorpion fauna in a hardwood floodplain forest of the Rhine valley near Ingelheim was investigated. Altogether 587 individuals representing two species from two families were captured using pitfall traps, trunk eclectors and by litter sieving. The warm, dry winter 2006/2007 exhibited a strong influence upon the activity of Neobisium carcinoides (Hermann, 1804). This winter event was followed by an extreme drought in April 2007, which affected the activity maximum of the corticolous species Chernes hahnii (C.L. Koch, 1839). In 2005 and 2006 the activity maximum of C. hahnii was observed in July, whereas in 2007 maturity was achieved earlier in May. Furthermore 31 individuals of N. carcinoides were captured in trunk eclectors. This climbing behaviour correlates with the presence of Lepidocyrtus lignorum (Collembola: Entomobryidae) on the trunks.
Keywords: activity, Collembola, drought, false scorpions, Germany, prey capture
Defensive decision making occurs when the decision-maker does not choose the option that is in the best interest of an organization or client but instead chooses a less effective but lower risk alternative that protects him or her in case something goes wrong. Such decisions are widespread across occupations and sectors and cause substantive damage to organizations. In a first step, we developed a scale to measure defensive decision making and test its validity. The scale covers two distinct but related dimensions: avoidance and approach. In a subsequent, two-wave study, we examined the antecedents of defensive decision making using conservation of resources theory as a theoretical lens. An environment characterized by higher psychological safety can reduce resource depletion and diminishes defensive decision making. In contrast, job insecurity can result in a threat to personal resources, which increases the likelihood that employees choose defensive decisions.
Practitioners points:
People engage in defensive decision making as a means to protect their own resources from exhaustion.
Organizations can reduce the number of defensive decisions by enhancing situational resources such as psychological safety.
The short and preliminarily validated scale we developed can be used to make defensive decisions visible in organizations.