Refine
Year of publication
Document Type
- Article (29956)
- Part of Periodical (11831)
- Book (8221)
- Doctoral Thesis (5594)
- Part of a Book (3622)
- Working Paper (3370)
- Review (2860)
- Contribution to a Periodical (2278)
- Preprint (1805)
- Report (1545)
Language
- German (41983)
- English (28357)
- French (1067)
- Portuguese (722)
- Multiple languages (306)
- Croatian (302)
- Spanish (301)
- Italian (194)
- mis (174)
- Turkish (148)
Is part of the Bibliography
- no (73879) (remove)
Keywords
- Deutsch (1037)
- Literatur (798)
- taxonomy (738)
- Deutschland (541)
- Rezension (491)
- new species (438)
- Frankfurt <Main> / Universität (341)
- Rezeption (320)
- Geschichte (291)
- Linguistik (268)
Institute
- Medizin (7369)
- Präsidium (5082)
- Physik (4113)
- Extern (2661)
- Wirtschaftswissenschaften (2657)
- Gesellschaftswissenschaften (2366)
- Biowissenschaften (2111)
- Biochemie und Chemie (1950)
- Center for Financial Studies (CFS) (1609)
- Informatik (1577)
Background: The use of patient-reported outcome measures (PROM) and caregiver-reported outcome measures can raise the patient centeredness of treatment and improve the quality of palliative care. Nevertheless, the everyday implementation of self-report in patients and caregivers is complex, and should be adapted for use in specific settings. We aimed to implement a set of outcome measures that included patient and caregiver self- and proxy-reported outcome measures in specialised outpatient palliative care (SOPC). In this study, we explore how the Integrated Palliative Outcome Scale (IPOS), IPOS Views on Care (IPOS VoC) and the Short-form Zarit Caregiver Burden Interview (ZBI-7) can be feasibly, acceptably and appropriately implemented in the daily care routines of SOPC.
Methods: Five SOPC teams were trained, and used the outcome measures in daily practice. Team members were mainly nurses and physicians. To investigate their feedback, we used a multi-method qualitative design consisting of focus groups with SOPC-team members (n = 14), field notes of meetings and conversations with the SOPC teams. In an iterative process, we analysed the findings using qualitative content analysis and refined use of the outcome measures.
Results: We found that integrating patient and caregiver outcome measures into daily care routines in SOPC is feasible. To improve feasibility, acceptability and appropriateness, the resulting burden on patients and relatives should be kept to a minimum, the usefulness of the measures must be understood, they should be used considerately, and administration must be manageable. We removed ZBI-7 from the set of measures as a result of feedback on its content and wording.
Conclusions: SOPC-team members have reservations about the implementation of PROM in SOPC, but with appropriate adjustments, its application in daily care is feasible, accepted and perceived as appropriate. Previous to use, SOPC-team members should be trained in how to apply the measures, in the design of manageable processes that include integration into electronic documentation systems, and in ongoing evaluation and support. They should also be taught how useful the measures can be.
Microstructural abnormalities in white matter (WM) are often reported in Alzheimer's disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.
Microstructural abnormalities in white matter (WM) are often reported in Alzheimer’s disease (AD) and may reflect primary or secondary circuitry degeneration (i.e., due to cortical atrophy). The interpretation of diffusion tensor imaging (DTI) eigenvectors, known as multiple indices, may provide new insights into the main pathological models supporting primary or secondary patterns of WM disruption in AD, the retrogenesis, and Wallerian degeneration models, respectively. The aim of this review is to analyze the current literature on the contribution of DTI multiple indices to the understanding of AD neuropathology, taking the retrogenesis model as a reference for discussion. A systematic review using MEDLINE, EMBASE, and PUBMED was performed. Evidence suggests that AD evolves through distinct patterns of WM disruption, in which retrogenesis or, alternatively, the Wallerian degeneration may prevail. Distinct patterns of WM atrophy may be influenced by complex interactions which comprise disease status and progression, fiber localization, concurrent risk factors (i.e., vascular disease, gender), and cognitive reserve. The use of DTI multiple indices in addition to other standard multimodal methods in dementia research may help to determine the contribution of retrogenesis hypothesis to the understanding of neuropathological hallmarks that lead to AD.
Auf der Grundlage der bisherigen Forschungsergebnisse zu Transfer und Interferenz wird die Übertragung sprachlichen Wissens in die Interimsprache in eine Theorie des Zweitspracherwerbs integriert. Transfer wird dabei als interlinguale Ausprägung der Generalisierung verstanden, eine Sichtweise, die die Untersuchungsergebnisse zu Bedingungen und Ursachen des Transfers in einen Erklärungszusammenhang mit anderen Phänomenen des Zweitspracherwerbs stellt. Darüberhinaus ermöglicht es diese Interpretation, eine Verbindung zu kognitiven Leistungen des Lerners beim Erstspracherwerb sowie beim Lernen überhaupt herzustellen.
In seinem neuen Buch bietet Karl Ubl einen weit gefassten Überblick seiner bisherigen Forschungen zur Lex Salica im Kontext seines Projektes an der Universität Köln zu den frühmittelalterlichen Rechtsüberlieferungen, beginnend mit den substantiellen Beobachtungen "Warum Barbaren Gesetze erlassen" (37–66) als Folge aus der Frage nach Einsatz und Nutzen der Rechtsbücher (Einleitung, 11–35). Er sieht die fränkische Lex in ihren Ursprüngen als identitätsstiftendes Instrument an ("Ein Monument der Alterität", 67–97, sowie als "Entwürfe von Gemeinschaft im 6. Jahrhundert", 99–135). ...
Integration in den Grenzregionen der Europäischen Union - die Europäische Union und ihre Bürger
(2002)
Die Arbeit setzt sich mit der Bedeutung der regionalen Ebene im Europäischen Integrationsprozess auseinander und untersucht die Rolle der Regionen in der Europäischen Union und ihren Mitgliedstaaten. Am Beispiel der Grenzregionen innerhalb der Europäischen Union werden die Fortschritte und die Auswirkungen der Europäischen Integration auf das Leben der europäischen Bürger dargestellt.
Background Although current molecular clock methods offer greater flexibility in modelling historical evolutionary events, calibration of the clock with dates from the fossil record is still problematic for many groups. Here we implement several new approaches in molecular dating to estimate evolutionary ages of Lacertidae, an Old World family of lizards with a poor fossil record and uncertain phylogeny. Four different models of rate variation are tested in a new program for Bayesian phylogenetic analysis called TreeTime, based on a combination of mitochondrial and nuclear gene sequences. We incorporate paleontological uncertainty into divergence estimates by expressing multiple calibration dates as a range of probabilistic distributions. We also test the reliability of our proposed calibrations by exploring effects of individual priors on posterior estimates. Results According to the most reliable model, as indicated by Bayes factor comparison, modern lacertids arose shortly after the K/T transition and entered Africa about 45 million years ago, with the majority of their African radiation occurring in the Eocene and Oligocene. Our findings indicate much earlier origins for these clades than previously reported, and we discuss our results in light of paleogeographic trends during the Cenozoic. Conclusions This study represents the first attempt to estimate evolutionary ages of a specific group of reptiles exhibiting uncertain phylogenetic relationships, molecular rate variation and a poor fossil record. Our results emphasize the sensitivity of molecular divergence dates to fossil calibrations, and support the use of combined molecular data sets and multiple, well-spaced dates from the fossil record as minimum node constraints. The bioinformatics program used here, TreeTime, is publicly available, and we recommend its use for molecular dating of taxa faced with similar challenges.
Cell-free expression represents an attractive method to produce large quantities of selectively labeled protein for NMR applications. Here, cell-free expression was used to label specific regions of the growth hormone secretagogue receptor (GHSR) with NMR-active isotopes. The GHSR is a member of the class A family of G protein-coupled receptors. A cell-free expression system was established to produce the GHSR in the precipitated form. The solubilized receptor was refolded in vitro and reconstituted into DMPC lipid membranes. Methionines, arginines, and histidines were chosen for 13C-labeling as they are representative for the transmembrane domains, the loops and flanking regions of the transmembrane α-helices, and the C-terminus of the receptor, respectively. The dynamics of the isotopically labeled residues was characterized by solid-state NMR measuring motionally averaged 1H-13C dipolar couplings, which were converted into molecular order parameters. Separated local field DIPSHIFT experiments under magic-angle spinning conditions using either varying cross polarization contact times or direct excitation provided order parameters for these residues showing that the C-terminus was the segment with the highest motional amplitude. The loop regions and helix ends as well as the transmembrane regions of the GHSR represent relatively rigid segments in the overall very flexible receptor molecule. Although no site resolution could be achieved in the experiments, the previously reported highly dynamic character of the receptor concluded from uniformly 13C labeled receptor samples could be further specified by this segmental labeling approach, leading to a more diversified understanding. of the receptor dynamics under equilibrium conditions