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This paper aims at reconstructing the development and role of German neurology between 1840 and 1940. Therefore a couple of original sources as well as selected material form the scattered secondary literature were assessed and reviewed. Since the middle of the nineteenth century, an intricate process of separation from internal medicine and psychiatry gradually led to forming a self-conscious community of German neurologists. While Moritz Heinrich Romberg had constructed a cognitive basis for neurology, scientific founders such as Wilhelm Erb, Carl Wernicke, Alois Alzheimer, Hermann Oppenheim, Max Nonne, and many others established the new discipline within modern medicine. In 1891, the first generation of “pure” neurologists succeeded in founding the German Journal for Neurology (Deutsche Zeitschrift für Nervenheilkunde) followed by an autonomous professional organisation, the Society of German Neurologists (Gesellschaft Deutscher Nervenärzte) in 1907. A variety of external factors, however, hampered the institutional evolution and thus the implementation of chairs and departments remained quite modest. In 1935, only 2 years after the National Socialists had seized power, the regulatory merger with the psychiatristsʼ society caused the cautious attempts of German neurologists for autonomy to end in complete failure. The imprisonment, murder and expulsion of neuroscientists declared as Jewish or non-Aryan caused profound changes in neurology, medicine, academic life, and health care in general. Further historical research is needed to reconstruct in detail the involvement of German neurologists in racial-hygienic and eugenic research as well as the institutional and scientific development of German neurology after World War II.
Wer waren die Literaturwissenschaftler, die bei der Gründung 1914 an die Universität Frankfurt am Main berufen wurden, die das akademische Leben der Stadt Frankfurt in der Weimarer Republik mitprägten, die nach 1933 in Frankfurt weiterhin Literaturwissenschaft betrieben oder die vertrieben wurden? Ein zweisemestriges interdisziplinäres Lehrforschungsseminar am Fachbereich 10 (Neuere Philologien) hat anlässlich des Jubiläums zum 100-jährigen Bestehen der Universität im Jahr 2014 Antworten auf diese Fragen gesucht. Das Ergebnis ist eine virtuelle Ausstellung mit 20 Porträts (Goethe Universität Frankfurt am Main, 2017). Diese Ausstellung war jedoch nur ein Teil einer Reihe von Veranstaltungen, die sich im Jubiläumsjahr der Frankfurter Universität mit den Literaturwissenschaften in Frankfurt befassten.
Les trois auteurs et voyageurs étudiés dans cet article (Albert Londres, André Gide, Michel Leiris) ont prêté leurs voix à l’anticolonialisme. Ils ont critiqué les effets du colonialisme européen en Afrique noire de la fin des années 1920 au début des années 1930. Toutefois, pour des raisons diverses allant d’aspects institutionnels aux sensibilités personnelles, leur engagement ne paraissait pas tout à fait le bienvenu, d’où leur hésitation à placer la parole politique au premier plan et à assumer le rôle d’intellectuel engagé. Ils ont alors justifié leur démarche par l’expérience personnelle et singulière du voyage et par l’urgence du sujet de leurs récits. Les formes littéraires qui en résultent (grand reportage, journal intime de voyage, journal ethnographique) ont profondément modernisé le genre du récit de voyage dans un moment critique de son évolution.
Built to colonize
(2019)
The extensive scholarship devoted to the congruence of mass-elite policy preferences lacks consensus about the meaning, comparison, and measurement across political settings. This makes comparisons difficult and raises obstacles to advancing the debates. This symposium aims to identify the diversity of methodological choices and to reflect systematically on several key choices of particular importance in understanding the congruence. The contributions to the symposium compare and contrast how several types of measurement fare in diverse political contexts in Eastern Europe, Latin America, North Africa, and East Asia, and what we can learn from those methodological choices.
In diesem Beitrag untersuchen wir Entwicklungstendenzen von Infrastrukturen in den Digitalen Geisteswissenschaften. Wir argumentieren, dass infolge (1) der Verfügbarkeit von immer mehr Daten über sozial-semiotische Netzwerke, (2) der Methodeninflation in geisteswissenschaftlichen Disziplinen, (3) der zunehmend hybriden Arbeitsteilung zwischen Mensch und Maschine und (4) der explosionsartigen Vermehrung künstlicher Texte ein erheblicher Anpassungsdruck auf die Weiterentwicklung solcher Infrastrukturen entstanden ist. In diesem Zusammenhang beschreiben wir drei Informationssysteme, die sich unter anderem durch die Interaktionsmöglichkeiten unterscheiden, die sie ihren Nutzern bieten, um solchen Herausforderungen zu begegnen. Dabei skizzieren wir mit VienNA eine neuartige Architektur solcher Systeme, welche aufgrund ihrer Flexibilität die Möglichkeit bieten könnte, letztere Herausforderungen zu bewältigen.
Der Einsatz von Portfolios in der Hochschullehre hat in den letzten Jahren deutlich zugenommen, und es bieten sich vielfältige Einsatzmöglichkeiten. So kann das Portfolio als modul- oder fachübergreifendes Entwicklungsportfolio über die gesamte Studiendauer, zur Darstellung erworbener Kompetenzen, als Präsentationsportfolio im Rahmen einzelner Lehrveranstaltungen, aber auch als Bewertungsportfolio und damit als Prüfungsinstrument eingesetzt werden (vgl. Weber, Hehn-Oldiges, Vogel & Stehle, 2017; Hornung-Prähauser, Geser, Hilzensauer & Schaffert, 2007). Neben dem klassischen Papier-Portfolio wird in den letzten Jahren der Einsatz sog. ePortfolios immer interessanter. Bei dieser digitalen Variante erstellen die Studierenden ihre Einträge direkt im Internet. Neben schriftlichen Einträgen ist das Einfügen von Bildern, Videos und Links möglich. Nach Fertigstellung wird das Portfolio von den Studierenden für den bzw. die Lehrende*n sowie ggf. für weitere oder alle Seminarteilnehmer*innen freigeschaltet, so dass auch Formen des Peer-Feedbacks einbezogen werden können. An der Goethe-Universität Frankfurt werden derzeit Einsatzmöglichkeiten des Portfolios im Rahmen der Lehrer*innenbildung erprobt. Der vorliegende Beitrag zeigt zunächst Möglichkeiten, wie ein Portfolio in der universitären Lehre als Prüfungsform eingesetzt werden kann. Im zweiten Teil wird der konkrete Einsatz im Rahmen eines Seminars für Lehramtsstudierende im Wintersemester 2018/2019 beschrieben. Zudem werden die Ergebnisse einer Befragung gezeigt, bei der die Seminarteilnehmer*innen zu ihren bisherigen Erfahrungen mit Portfolios in der Hochschullehre sowie zum Einsatz des ePortfolios als Prüfungsform im genannten Seminar befragt wurden.
Information asymmetry and its implications in online purchasing behaviour: a country case study
(2020)
The objective of this study is to analyse how certain variables in the online market affect the decision-making trajectory and actions toward reducing the information asymmetry faced in online purchasing. A survey and observation are conducted in order to understand the behavior and perceptions of online buyers toward the information given in online platforms. Descriptive and correlation analysis have been employed in order to evaluate the data collected and test the correlation between variables of the research model. It results that most participants take for granted the fact that sellers have more information than them when entering into a transaction agreement and this makes them feel inferior towards the superior power sellers possess in such interactions. This makes the traditional markets more preferred for them, however multiple sources such as reviews and ratings result as an alternative way of reducing the perceived information asymmetry.
In einer digital geprägten Welt stehen Lehrkräfte vor zahllosen Herausforderungen bezüglich der Mediennutzung in ihrem Unterricht. Kinder und Jugendliche konsumieren Medien durch soziale Netzwerke, Messenger und vor allem in Form von Videos, Filmen und Serien. An der Goethe-Universität werden die aktuellen bildungspolitischen und gesellschaftlichen Forderungen nach medienkompetenten Lehrkräften u.a. in der ersten Phase der Ausbildung aufgegriffen. Im hier vorgestellten bildungswissenschaftlichen Seminar «Mediendidaktik im Kontext Schule» werden Studierende daher unter Anwendung der Methode «Lernen durch Lehren» zur Produktion eigener Erklärvideos in Kleingruppen angeleitet. Dadurch werden die Studierenden zu Expertinnen und Experten, während sie den Videoerstellungsprozess kennenlernen und Mediennutzungskompetenzen ausbilden. Durch die Verzahnung mit Feedbackschleifen und Reflexionsaufgaben als Teil des studentischen Portfolios wurde der bewusste und reflektierte Umgang mit Medien in der späteren Berufspraxis angestrebt. Die Lehrveranstaltung wurde prozessbegleitend und anhand eines Online-Fragebogens summativ evaluiert. Die Ergebnisse zeigen zwar den anhaltenden Bedarf zur Instruktion während der Medienproduktion, aber vor allem das Interesse an digitalen Medien. Die Studierenden erlebten den Lernprozess als leistungsmotivierend, produktiv und betonten die Relevanz der Themen und Ziele des Seminars für die spätere Berufspraxis. Zukünftige Lehrkräfte können in jeder Ausbildungsphase von Praxiserfahrung im Umgang mit digitalen Medien profitieren und sollten dahingehend weitere Angebote während des Studiums und darüber hinaus erhalten.
Um leitor de Walter Benjamin: dialética, interpretação e materialismo em Theodor W. Adorno, 1931-2
(2019)
O objetivo do artigo édiscutir a influência do livro Origem do drama trágico alemão(1928) de Walter Benjamin sobre duas preleções de Theodor W. Adorno na Universidade de Frankfurt, a saber: “A atualidade da filosofia” (1931) e “A ideia de história natural” (1932). Com isso, procurou-se, por um lado, indicar especificamente a influência benjaminiana sobre a ideia de constelação e, por outro, esclarecer as fundações histórico-filosóficas da ideia de história natural, que se encontram no centro das reflexões epistemológicas deAdorno. Dessa maneira, é possível compreender as concepções de dialética, interpretação e materialismo trabalhadas por Adorno com o propósito de caracterizar sua própria tarefa filosófica no início da década de 1930.
O artigo toma as críticas ao entrelaçamento entre direito e violência como um ponto de partida para explorar a possibilidade de um "tertiumdo direito". Desse modo, busca superar a suposição dicotômica básica que enxerga o direito sempre oscilando entre uma apologia à violência, de um lado, e uma utopia da razão, de outro. O texto analisa a possibilidade dessetertium, uma "força legal" além da violência legal e da razão legal, em quatro passos, recorrendo ao trabalho de Jacques Derrida e de autores da primeira geração da Escola de Frankfurt, em particular, de Theodor Adorno e Walter Benjamin. Argumenta que, em um primeiro passo, o direito precisa ser dissociado do Estado. A violência jurídica, entretanto, não se origina apenas do laço entre direito e poder de Estado. O direito é em si mesmo violento, mesmo quando não é direito de Estado. O segundo passo da crítica legal consiste, portanto, na recordação da violência do direito, seguido por um terceiro, que pede a transformação da violência em força. Essas três instâncias da crítica são as precondições para um passo último e essencial, de acordo com o qual a crítica do direito deve facilitar a transcendência da violência jurídica, tomando o direito e a sua promessa de justiça ao pé da letra com a finalidade de voltar essa promessa contra o próprio direito.
Promove-se uma recuperação do debate endógeno estabelecido entre alguns pensadores da Escola de Frankfurt, sobretudo no que se refere às diferentes perspectivas de análise sobre as relações entre ação e estrutura social, bem como as distintas percepções acerca das racionalidades (prática ou comunicativa) que organizam a conexão entre os indivíduos e a sociedade. Verifica-se o modo como os autores ligados à teoria crítica compreenderam as relações entre esferas subjetivas e estruturais em termos de possibilidades de emancipação social e de exercício de práticas deliberativas. Nessa perspectiva, considera-se uma cisão teórica estabelecida no interior da própria escola, cuja expressão se dá a partir das diferenças epistemológicas existentes entre o núcleo central do pensamento frankfurtiano e um conjunto de autores periféricos. Os trabalhos produzidos por esse núcleo “marginal”, bem como seu posterior refinamento na obra de Habermas, apresentam alternativas teóricas de caráter relacional que contrapõem a visão estrutural e cética presente nos trabalhos de Horkheimer, Adorno e Marcuse. É justamente na recuperação dessas fronteiras endógenas que se pretende ponderar as possíveis contribuições do pensamento frankfurtiano para uma perspectiva crítica da sociedade contemporânea.
Failed jump landings represent a key mechanism of musculoskeletal trauma. It has been speculated that cognitive dual-task loading during the flight phase may moderate the injury risk. This study aimed to explore whether increased visual distraction can compromise landing biomechanics. Twenty-one healthy, physically active participants (15 females, 25.8 ± 0.4 years) completed a series of 30 counter-movement jumps (CMJ) onto a capacitive pressure platform. In addition to safely landing on one leg, they were required to memorize either one, two or three jersey numbers shown during the flight phase (randomly selected and equally balanced over all jumps). Outcomes included the number of recall errors as well as landing errors and three variables of landing kinetics (time to stabilization/TTS, peak ground reaction force/pGRF, length of the centre of pressure trace/COPT). Differences between the conditions were calculated using the Friedman test and the post hoc Bonferroni-Holm corrected Wilcoxon test. Regardless of the condition, landing errors remained unchanged (p = .46). In contrast, increased visual distraction resulted in a higher number of recall errors (chi² = 13.3, p = .001). Higher cognitive loading, furthermore, appeared to negatively impact mediolateral COPT (p < .05). Time to stabilization (p = .84) and pGRF (p = .78) were unaffected. A simple visual distraction in a controlled experimental setting is sufficient to adversely affect landing stability and task-related short-term memory during CMJ. The ability to precisely perceive the environment during movement under time constraints may, hence, represent a new injury risk factor and should be investigated in a prospective trial.
Tropical cyclones (TC) represent a substantial threat to life and property for Caribbean and adjacent populations. The prospective increase of TC magnitudes, expressed in the 15th chapter of the IPCC AR5 report, entails a rising probability of ecological and social disasters, which were tragically exemplified by several severe Caribbean TC strikes during the past 20 years. Modern IPCC-grade climate models, however, still lack the required spatial and temporal resolution to accurately consider the underlying boundary conditions that modulate long-time TC patterns beyond the Instrumental Era. It is thus necessary to provide a synoptic mechanistic understanding regarding the origin of such long-time patterns, in order to predict reliable changes of TC magnitude and frequency under future climate scenarios. Caribbean TC records are still rare and often lack the necessary continuity and resolution to overcome these limitations. Here, we report on an annually-resolved sedimentary archive from the bottom of the Great Blue Hole (Lighthouse Reef, Belize). The TC record encompasses 1885 years and extends all existing site-specific TC archives both in terms of resolution and duration. We identified a likely connection between long-term TC patterns and climate phenomena responses to Common Era climate variations and offer a conceptual and comparative view considering several involved tropospheric and oceanographic control mechanisms such as the El-Niño-Southern-Oscillation, the North Atlantic Oscillation and the Atlantic Multidecadal Oscillation. These basin-scaled climate modes exercise internal control on TC activity by modulating the thermodynamic environment (sea-surface temperature and vertical wind shear stress dynamics) for enhanced/suppressed TC formation both on millennial (primary) and multi-decadal (secondary) time scales. We interpret the beginning of the Medieval Warm Period (MWP) as an important time interval of the Common Era record and suspect that the southward migration of the intertropical convergence zone (ITCZ) caused, in combination with extensive hydro-climate changes, a shift in the tropical Atlantic TC regime. The TC activity in the south-western Caribbean changed in general from a stable and less active stage (100–900 CE) to a more active and variable state (1,100 CE-modern).
This work presents, to our knowledge, the first completely passive imaging with human-body-emitted radiation in the lower THz frequency range using a broadband uncooled detector. The sensor consists of a Si CMOS field-effect transistor with an integrated log-spiral THz antenna. This THz sensor was measured to exhibit a rather flat responsivity over the 0.1–1.5-THz frequency range, with values of the optical responsivity and noise-equivalent power of around 40 mA/W and 42 pW/√Hz, respectively. These values are in good agreement with simulations which suggest an even broader flat responsivity range exceeding 2.0 THz. The successful imaging demonstratestheimpressivethermalsensitivitywhichcanbeachievedwithsuchasensor. Recording of a 2.3×7.5-cm2-sized image of the fingers of a hand with a pixel size of 1 mm2 at a scanning speed of 1 mm/s leads to a signal-to-noise ratio of 2 and a noise-equivalent temperature difference of 4.4 K. This approach shows a new sensing approach with field-effect transistors as THz detectors which are usually used for active THz detection.
The purpose of this study consists of the identification of implantologic and prosthetic methods and techniques used in substance loss rehabilitation, associated with identifying the specific biomaterials in perfect accordance with each case particularities, without leaving aside the bone-tissue deficiency etiology. A representative number of clinical cases were selected, cases which are relevant for the chosen theme. The possibility of reconstructing the natural parameters of the edentulous alveolar ridge areas is various, starting with augmentation materials of the autogenous and heterograft type biomaterials(Bio-Oss, Grafton, Cerasorb si MBCP) including the mixing of these two types of biomaterials, and going to epitheses, which are the best choise for complex substance loss.
Programele computerizate au un rol indiscutabil în atingerea unor standarde ridicate în procesul educațional. Pe de altă parte acestea sunt instrumente eficiente în identificarea particularităților cazurilor clinice, evaluarea acestora în conformitate cu indicii clinico-biologici specifici. În timpul procesului didactic, simularea are un rol esenţial, ca o prefaţă la procedurile practice care formează abilităţile practice pe fiecare entitate clinică în medicina dentară.
Axel Honneth associates his reading of Hegel with Winnicott's maturational development theory, in order to defend theses on intersubjectivity and recognition. That connection between philosophy and psychoanalysis is a target of criticism from two Hegelians: Joel Whitebook, a reader of Freud, and Judith Butler, a critical reader of Freud and Lacan. At the core of the controversy is Honneth's rejection of the work of the negative that is performed by Freud's death drive. We intend on following in the wake of that debate, and thus investigate the reasons and consequences for social criticism of Honneth's rejection of Freud's death drive.
Axel Honneth associa sua leitura de Hegel à psicologia da maturação de Winnicott de modo a defender teses sobre intersubjetividade e reconhecimento. Esta articulação entre filosofia e psicanálise é objeto da crítica de dois hegelianos: Joel Whitebook, leitor de Freud, e Judith Butler, leitora crítica de Freud e Lacan. No centro da polêmica está a rejeição honnethiana ao trabalho do negativo realizado pela pulsão de morte freudiana. Pretendemos seguir o rastro deste debate e investigar as razões e consequências para a crítica social da recusa do frankfurtiano à pulsão.
This article corrects the following: Hope in political philosophy,
Claudia Blöser Jakob Huber Darrel Moellendorf. Volume 15Issue 5Philosophy Compass First Published online: April 17, 2020.
It has come to the author's attention that the reference citation of ‘Meirav, 2009’ on page 2 of his published article entitled, ‘Hope in political philosophy’ does not provide bibliographical details regarding the article and does not include it in its list of works cited.
Here is the bibliographical information: Meirav, A. (2009). The nature of hope. Ratio, 22, 216–233.
Hope in political philosophy
(2020)
The language of hope is a ubiquitous part of political life, but its value is increasingly contested. While there is an emerging debate about hope in political philosophy, an assessment of the prevalent scepticism about its role in political practice is still outstanding. The aim of this article is to provide an overview of historical and recent treatments of hope in political philosophy and to indicate lines of further research. We argue that even though political philosophy can draw on recent analyses of hope in analytic philosophy, there are distinct challenges for an account of hope in political contexts. Examples such as racial injustice or climate change show the need for a systematic normative account that is sensitive to the unavoidability of hope in politics as much as its characteristic dangers.
Responsibility for increasing mitigation ambition in light of the right to sustainable development
(2020)
The international community is currently in the midst of a facilitative dialogue about how to increase mitigation ambition under the terms of Paris Agreement. This dialogue concerns centrally considerations of equity, which includes matters of both justice and responsibility. I defend the importance of the right to sustainable development in this regard. I argue that if the right of states to pursue poverty eradicating human development is to be respected, then there is plausible interpretation of responsibility for mitigation in which a state’s ability to pay is the central consideration, where that ability is measured by its human development level. That conception of responsibility should be applied to considerations of how increase mitigation ambition.
This article aims to shed light on some core challenges of liberating social criticism. Its centerpiece is an intuitively attractive account of the nature and difficulty of critical social thought that nevertheless goes missing in many philosophical conversations about critique. This omission at bottom reflects the fact that the account presupposes a philosophically contentious conception of rationality. Yet the relevant conception of rationality does in fact inform influential philosophical treatments of social criticism, including, very prominently, a left Hegelian strand of thinking within contemporary Critical Theory. Moreover, it is possible to mount a defense of the conception by reconstructing, if with various qualifications and additions, an argument from classic—i.e., mid twentieth-century—Anglo-American philosophy of the social sciences, in particular, the argument that forms the backbone of Peter Winch’s The Idea of a Social Science. Winch draws his guiding insights from the later philosophy of Wittgenstein, and one of the payoffs of considering Winch’s Wittgenstein-inspired work against the backdrop of Hegel-inspired work in Critical Theory is to contest the artificial professional strictures that are sometimes taken to speak against reaching across the so-called ‘Continental Divide’ in philosophy. The larger payoff is advancing, by means of this philosophically ecumenical approach, the enterprise of liberating social thought.
Anerkjennelse og menneskeverdets forankring : henimot en transnasjonal anerkjennelsespolitikk
(2011)
Anerkjennelse spiller en nøkkelrolle for menneskeverdet innenfor Frankfurterskolens kritiske teori. Men hvorledes skal «anerkjennelse» forstås? Og hvorledes kan anerkjennelse innløse menneskeverdets universelle og egalitære fordring? Jürgen Habermas' og Axel Honneths «familiekrangel» bidrar med relevant innsikt om relasjonen mellom menneskeverd og anerkjennelse. Dette er en innsikt med affinitet til menneskeverdets normative legitimering i dagens transnasjonaliserte verden.
El concepto de la industria cultural como un problema: una revisión de Adorno, Horkheimer y Benjamin
(2014)
El siguiente documento rastrea la idea de la industria cultural desde su origen como un concepto filosófico en el trabajo de dos autores de la Escuela de Frankfurt, Adorno y Horkheimer. Debido a que el estado lo usa instrumentalmente, la definición de este concepto ha cambiado. El artículo ahonda en la perspectiva de los autores de la Escuela de Frankfurt, agregando las contribuciones y críticas de Walter Benjamin sobre la obra de arte en la era de la reproducción mecánica, con el fin de establecer una relación entre ambas perspectivas.
O Instituto de Pesquisas Sociais (Institut für Sozialforschung) foi fundado em 1923, como um anexo da Universidade de Frankfurt, hoje intitulada Johann Wolfgang Goethe-Universität Frankfurt am Main. A Escola de Frankfurt, desde 1930, foi dirigida por Max Horkheimer, e reunia pensadores como Theodor W. Adorno, Erich Fromm, Herbert Marcuse, e, contou também como membro do "círculo de fora" do Instituto, Walter Benjamin. Estes intelectuais formularam, como sabemos, o que conhecemos como "Teoria Crítica". Nos anos sessenta, temos a "segunda geração", marcado pela obra de Jürgen Habermas. Aquele que foi seu assistente entre 1984 e 1990, Axel Honneth, veio a ser o Diretor do Instituto frankfurtiano desde 2001. Com ele inaugura-se a "terceira geração" da Escola, cuja proposta consiste em relançar a "Teoria Crítica", sobretudo a partir do livro Kampf um Anerkennung. Zur moralischen Grammatik sozialer Konflikte, de 1992 (publicado no Brasil como Luta por reconhecimento - A Gramática Moral dos Conflitos Sociais. Trad. Luiz Repa. São Paulo: Ed. 34, 2003), tendo como ponto de partida a Fenomenologia do Espírito de Hegel. Honneth centra sua reflexão na "teoria do reconhecimento" e, através dela, são apresentados os limites da obra das gerações de frankfurtianos anteriores. A falta de reconhecimento passa a ser vista como base dos conflitos interpessoais, sociais e políticos na atualidade. Mais recentemente, Honneth publicou Das Recht der Freiheit (Berlin, Suhrkamp, 2011 - O direito à liberdade) e Die Idee des Sozialismus (Berlin, Suhrkamp, 2015 - A ideia do socialismo), sustentando que o socialismo está vivo como ideia, e tem como cerne a liberdade social. Foi em 2014, no Instituto de Pesquisas Sociais de Frankfurt, que aconteceu o encontro e a entrevista com o Diretor do Instituto, Axel Honneth. O foco da breve entrevista, aqui apresentada no original alemão e em tradução portuguesa.
El ensayo contrasta dos grandes posturas ante el fenómeno omnipresente de la técnica, en estricta relación con las concepciones profundas de lo racional y lo natural que le subyacen. Ortega por un lado, y Adorno, Horkheimer y Marcuse por otro, son excelentes ejemplos de visiones muy diferentes pero complementarias, que además conjugan aspectos antropológicos, históricos y políticos de gran importancia para ofrecer una panorámica global en este campo, sin reduccionismo alguno, y ayudar así a repensar nuestro presente.
The following article attempts to clarify the ambivalent relationship that Max Horkheimer and Herbert Marcuse developed with the vitalist and phenomenological tendencies that permeated philosophy and the social sciences during the Weimar Republic. More precisely, it traces how both thinkers, in spite of acknowledging the “truth moment” contained in the criticism that the philosophical exponents of both movements (Husserl, Bergson, Dilthey) developed of 19th century positivism, also recognized in its shallow popularization the advancement of a dangerous philosophical irrationalism, suspicious of science and Enlightenment values, that would soon become an accomplice to the rise of fascism.
O ensaio traz como base a crítica ao capitalismo, no que se refere aos efeitos negativos que ele impõe aos indivíduos, a partir dos estudos da primeira geração da Escola de Frankfurt. Analisar-se-á a história das ideias a partir de Walter Benjamin, Herbert Marcuse, Theodor Adorno e Max Horkheimer. Benjamin afirma que vive-se a perda da aura das obras de arte, já que a sua comercialização faz com que se perca a essência daquelas obras. Ademais, a imposição da novidade às obras e aos produtos consumidos representa uma ferramenta de manipulação do capitalismo, culminando na pobreza da experiência humana. Marcuse afirma que a sociedade vive o princípio do desempenho, que provoca modos de vida uniformizados, baseados numa concepção de trabalho e diversão homogêneos. Adorno propôs que o tempo livre provocava uma sensação de liberdade nos indivíduos, mas, na realidade, tratava-se do exercício de uma não liberdade, já que as formas de diversão seguiam à risca os padrões exigidos pelo capital. A partir do método adotado pela própria Teoria Crítica, afirma-se que a presente discussão teórica só se torna efetiva quando aplicada à prática, à sociedade atual.
Este estudo tem como finalidade analisar a perspectiva da arte como parte do aparato de dominação social, desenvolvida na obra A ideologia da sociedade industrial, de Herbert Marcuse. Para isso, utilizaremos como referência constante as teorias propostas pelos filósofos da Escola de Frankfurt, em especial Theodor W. Adorno e Max Horkheimer no que diz respeito, sobretudo, ao termo “indústria cultural”, cujo conceitoaparece no capítulo homônimo de Adialética do esclarecimento. Apoiaremo-nos também na tese de doutorado de Imaculada Kangussu, intituladaLeis da liberdade: as relações entre Estética e Política na Filosofia de Herbert Marcuse,e, ainda, nas demais obras marcuseanas, com destaque para Erose Civilização: uma interpretação filosófica do pensamento de Freud.
Depletion of yeast/fly Ataxin-2 rescues TDP-43 overexpression toxicity. In mouse models of Amyotrophic Lateral Sclerosis via TDP-43 overexpression, depletion of its ortholog ATXN2 mitigated motor neuron degeneration and extended lifespan from 25 days to >300 days. There is another ortholog in mammals, named ATXN2L (Ataxin-2-like), which is almost uncharacterized but also functions in RNA surveillance at stress granules. We generated mice with Crispr/Cas9-mediated deletion of Atxn2l exons 5-8, studying homozygotes prenatally and heterozygotes during aging. Our novel findings indicate that ATXN2L absence triggers mid-gestational embryonic lethality, affecting female animals more strongly. Weight and development stages of homozygous mutants were reduced. Placenta phenotypes were not apparent, but brain histology showed lamination defects and apoptosis. Aged heterozygotes showed no locomotor deficits or weight loss over 12 months. Null mutants in vivo displayed compensatory efforts to maximize Atxn2l expression, which were prevented upon nutrient abundance in vitro. Mouse embryonal fibroblast cells revealed more multinucleated giant cells upon ATXN2L deficiency. In addition, in human neural cells, transcript levels of ATXN2L were induced upon starvation and glucose and amino acids exposure, but this induction was partially prevented by serum or low cholesterol administration. Neither ATXN2L depletion triggered dysregulation of ATXN2, nor a converse effect was observed. Overall, this essential role of ATXN2L for embryogenesis raises questions about its role in neurodegenerative diseases and neuroprotective therapies.
Manufacturing processes of custom implant abutments may contaminate their surfaces with micro wear deposits and generic pollutants. Such particulate debris, if not removed, might be detrimental and provoke inflammatory reactions in peri-implant tissues. Although regulatory guidelines for adequate cleaning, disinfection, or sterilization exist, there does not appear to be a consistent application and data on the amount and extent of such contaminants is lacking. The aim of the present in vitro study was to evaluate the quality and quantity of processing-related surface contamination of computer-aided design/computer-aided manufacturing (CAD/CAM) abutments in the state of delivery and after ultrasonic cleaning. A total of 28 CAD/CAM monotype and hybrid abutments were cleaned and disinfected applying a three-stage ultrasonic protocol (Finevo protocol). Before and after cleaning, the chemical composition and the contamination of the abutments were assessed using scanning electron microscopy (SEM), dispersive X-ray spectroscopy(EDX),andcomputer-aidedplanimetricmeasurement(CAPM).Inthedeliverycondition, monotype abutments showed a significantly higher amount of debris compared to hybrid abutments (4.86±6.10% vs. 0.03 ± 0.03%, p < 0.001). The polishing process applied in the laboratory after bonding the hybrid abutment components reduces the surface roughness and thus contributes substantially to their purity. The extent of contamination caused by computer-aided manufacturing of custom abutments can be substantially minimized using a three-stage ultrasonic protocol.
Alcoholism is one of the leading and increasingly prevalent reasons of liver associated morbidity and mortality worldwide. Alcoholic hepatitis (AH) constitutes a severe disease with currently no satisfying treatment options. Lipoxin A4 (LXA4), a 15-lipoxygenase (ALOX15)-dependent lipid mediator involved in resolution of inflammation, showed promising pre-clinical results in the therapy of several inflammatory diseases. Since inflammation is a main driver of disease progression in alcoholic hepatitis, we investigated the impact of endogenous ALOX15-dependent lipid mediators and exogenously applied LXA4 on AH development. A mouse model for alcoholic steatohepatitis (NIAAA model) was tested in Alox12/15+/+ and Alox12/15−/− mice, with or without supplementation of LXA4. Absence of Alox12/15 aggravated parameters of liver disease, increased hepatic immune cell infiltration in AH, and elevated systemic neutrophils as a marker for systemic inflammation. Interestingly, i.p. injections of LXA4 significantly lowered transaminase levels only in Alox12/15−/− mice and reduced hepatic immune cell infiltration as well as systemic inflammatory cytokine expression in both genotypes, even though steatosis progressed. Thus, while LXA4 injection attenuated selected parameters of disease progression in Alox12/15−/− mice, its beneficial impact on immunity was also apparent in Alox12/15+/+ mice. In conclusion, pro-resolving lipid mediators may be beneficial to reduce inflammation in alcoholic hepatitis.
Soil degradation can have an impact on the soil microbiota, but its specific effects on soil fungal communities are poorly understood. In this work, we studied the impact of soil degradation on the richness and diversity of communities of soil fungi, including three different degrees of degradation in Germany and Panama. Soil fungi were isolated monthly using the soil-sprinkling method for 8 months in Germany and 3 months in Panama, and characterized by morphological and molecular data. Soil physico-chemical properties were measured and correlated with the observed values of fungal diversity. We isolated a total of 71 fungal species, 47 from Germany, and 32 from Panama. Soil properties were not associated with fungal richness, diversity, or composition in soils, with the exception of soil compaction in Germany. The geographic location was a strong determinant of the soil fungal species composition although in both countries there was dominance by members of the orders Eurotiales and Hypocreales. In conclusion, the results of this work do not show any evident influence of soil degradation on communities of soil fungi in Germany or Panama.
Autism spectrum disorders (ASD) are highly heritable and are characterized by deficits in social communication and restricted and repetitive behaviors. Twin studies on phenotypic subdomains suggest a differing underlying genetic etiology. Studying genetic variation explaining phenotypic variance will help to identify specific underlying pathomechanisms. We investigated the effect of common variation on ASD subdomains in two cohorts including >2500 individuals. Based on the Autism Diagnostic Interview-Revised (ADI-R), we identified and confirmed six subdomains with a SNP-based genetic heritability h2SNP = 0.2–0.4. The subdomains nonverbal communication (NVC), social interaction (SI), and peer interaction (PI) shared genetic risk factors, while the subdomains of repetitive sensory-motor behavior (RB) and restricted interests (RI) were genetically independent of each other. The polygenic risk score (PRS) for ASD as categorical diagnosis explained 2.3–3.3% of the variance of SI, joint attention (JA), and PI, 4.5% for RI, 1.2% of RB, but only 0.7% of NVC. We report eight genome-wide significant hits—partially replicating previous findings—and 292 known and novel candidate genes. The underlying biological mechanisms were related to neuronal transmission and development. At the SNP and gene level, all subdomains showed overlap, with the exception of RB. However, no overlap was observed at the functional level. In summary, the ADI-R algorithm-derived subdomains related to social communication show a shared genetic etiology in contrast to restricted and repetitive behaviors. The ASD-specific PRS overlapped only partially, suggesting an additional role of specific common variation in shaping the phenotypic expression of ASD subdomains.
Introduction End-of-life care is an essential task performed by most healthcare providers and often involves decision-making about how and where patients want to receive care. To provide decision support to healthcare professionals and patients in this difficult situation, we will systematically review a knowledge cluster of the end-of-life care preferences of older patients with multimorbidity that we previously identified using an evidence map.
Methods and analysis We will systematically search for studies reporting end-of-life care preferences of older patients (mean age ≥60) with multimorbidity (≥2 chronic conditions) in MEDLINE, CINAHL, PsycINFO, Social Sciences Citation Index, Social Sciences Citation Index Expanded, PSYNDEX and The Cochrane Library from inception to September 2019. We will include all primary studies that use quantitative, qualitative and mixed methodologies, irrespective of publication date and language.
Two independent reviewers will assess eligibility, extract data and describe evidence in terms of study/population characteristics, preference assessment method and end-of-life care elements that matter to patients (eg, life-sustaining treatments). Risk of bias/applicability of results will be independently assessed by two reviewers using the Mixed-Methods Appraisal Tool. Using a convergent integrated approach on qualitative/quantitative studies, we will synthesise information narratively and, wherever possible, quantitatively.
Ethics and dissemination Due to the nature of the proposed systematic review, ethics approval is not required. Results from our research will be disseminated at relevant (inter-)national conferences and via publication in peer-reviewed journals. Synthesising evidence on end-of-life care preferences of older patients with multimorbidity will improve shared decision-making and satisfaction in this final period of life.
Geochemical analyses result of prehistoric pottery from the site of Tol-e Kamin (Fars, Iran) by pXRF
(2020)
A series of pottery samples from the Iranian site Tol-e Kamin, ranging from pre-historical period to the New Elamite, were analyzed in order to study the geochemical variability of the pottery assemblage. A total amount of 168 measurements were obtained using a portable XRF device and were statistically handled. The results could successfully distinguish the geochemical composition of potteries from the chalcolithic to the New Elamite periods in the Kur River Basin. A major shift in the use of different clay sources could be detected since the Proto Elamite period and afterward, in which the carbonated and marl content clays represented by Ca, Ba and Sr shifted to clay sources with a tendency to non-carbonate silty clay Al, Ti, and Fe from a different geological background. The results stress the importance of further provenance studies to address issues of trade and exchange possibilities in southwestern Iran.
Recent studies suggested an important contribution of sphingosine-1-phospate (S1P) signaling via its specific receptors (S1PRs) in the production of pro-inflammatory mediators such as Interleukin (IL)-1β in cancer and inflammation. In an inflammation-driven cancer setting, we previously reported that myeloid S1PR1 signaling induces IL-1β production by enhancing NLRP3 (NOD-, LRR- and Pyrin Domain-Containing Protein 3) inflammasome activity. However, the autocrine role of S1P and enzymes acting on the S1P rheostat in myeloid cells are unknown. Using human and mouse macrophages with pharmacological or genetic intervention we explored the relative contribution of sphingosine kinases (SPHKs) in NLRP3 inflammasome activity regulation. We noticed redundancy in SPHK1 and SPHK2 activities towards macrophage NLRP3 inflammasome transcriptional induction and IL-1β secretion. However, pharmacological blockade of both kinases in unison completely abrogated NLRP3 inflammasome induction and IL-1β secretion. Interestingly, human and mouse macrophages demonstrate varied responses towards SPHKs inhibition and IL-1β secretion. Clinical datasets of renal cell carcinoma and psoriasis patients showed a positive correlation between enzymes affecting the S1P rheostat with NLRP3 inflammasome components expression, which corroborates our finding. Our data provide a better understanding on the role of SPHKs and de novo synthesized S1P in macrophage NLRP3 inflammasome activation
We study simulated animats in terms of wheeled robots with the most simple neural controller possible – a single neuron per actuator. The system is fully self-organized in the sense that the controlling neuron receives uniquely the actual angle of the wheel as an input. Non-trivial locomotion results in structured environments, with the robot determining autonomously the direction of movement (time-reversal symmetry is spontaneously broken). Our controller, which mimics the mechanism used to transmit power in steam locomotives, abstracts from the body plan of the animat, working without problems also in the presence of noise and for chains of individual two-wheeled cars. Being fully compliant our controller may be also used, in the spirit of morphological computation, as a basic unit for higher-level evolutionary algorithms.
Discussions regarding the planned European Deposit Insurance Scheme (EDIS), the missing third pillar of the European Banking Union, have been ongoing since the Commission published its initial legisla-tive proposal in 2015. A breakthrough in negotiations has yet to be achieved. The gridlock on EDIS is most commonly attributed to moral hazard concerns over insufficient risk reduction harboured on the side of northern member states, particularly Germany, due to the weak state of some other member states’ banking sectors. While moral hazard based on uneven risk reduction is helpful for explaining divergent member-state preferences on the scope of necessary risk reduction, this does not explain preferences on the institutional design of EDIS. In this paper, we argue that contrary to persistent differences on necessary risk reduction, preferences regarding the institutional design of EDIS have become more closely aligned. We analyse how preferences on EDIS developed in the key member states of Germany, France, and Italy. In all sampled countries, we find path-dependent benefits con-nected to the current design of national Deposit Guarantee Schemes (DGS) that shifted preferences of the banking sector or significant subsectors in favour of retaining national DGSs. Overall, given that a compromise on risk-reduction can be accomplished, we argue that current preferences in these key member states provide an opportunity to implement EDIS in the form of a reinsurance system that maintains national DGSs in combination with a supranational fund.
Background: Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C).
Objectives: A pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE).
Methods: One to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina.
Results: Baseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081).
Conclusions: Baseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).
Bei der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) handelt es sich um eine hochprävalente Erkrankung, die bisher insbesondere im Erwachsenenalter nur unzureichend berücksichtigt wurde. Neben den Kernsymptomen bestehend aus Einschränkungen in der Aufmerksamkeit sowie einem erhöhten Maß an Hyperaktivität und Impulsivität gilt es, Komorbiditäten und Beeinträchtigungen zu berücksichtigen, die mit dieser Erkrankung einhergehen. In früheren Studien konnte bereits nachgewiesen werden, dass sowohl Kinder als auch Erwachsene mit einer ADHS vermehrte Unfälle und infolgedessen eine erhöhte Rate an stationären Behandlungen aufweisen. Zusätzlich besteht bei ADHS-Betroffenen ein höheres Risiko, frühzeitig zu versterben, wobei Unfälle als unnatürliche Todesursache den häufigsten Grund darstellen. Bisher existieren auf internationaler Ebene einige Studien, die sich mit den Zusammenhängen von adulter ADHS und Unfallraten beschäftigten. Eine differenzierte Betrachtung, die eine deutsche Population einschließt und den Einfluss des Geschlechts auf das Unfallgeschehen bei ADHS-Betroffenen untersucht, wurde bisher nicht realisiert. Aus diesen Gründen führten wir eine Querschnittsstudie auf unfallchirurgischen Stationen an zwei Kliniken in Frankfurt am Main durch. Im Rahmen der Studie sollte die Prävalenz von adulter ADHS bei stationär betreuten Unfallopfern ermittelt und mögliche unfallcharakteristische Unterschiede zwischen den Geschlechtern der ADHS-Positivkohorte erfasst werden.
Mithilfe der etablierten Adult ADHD Self-Report Scale (ASRS v1.1) der WHO wurden alle Unfallopfer, die den Einschlusskriterien entsprachen, auf adulte ADHS gescreent. Bei der Auswertung des ASRS verwendeten wir zwei unterschiedliche Methoden, die bereits in früheren Studien zur Anwendung kamen. Durch einen eigens erstellten Unfallfragebogen konnten Unfallcharakteristika sowie psychische Komorbiditäten der ADHSPositivkohorte erfasst werden. Zusätzlich erhoben wir zum Vergleich die Unfallcharakteristika bei einer nicht von ADHS betroffenen Kontrollgruppe. Bei einem Teil der positiv gescreenten Patienten wurde eine ausführliche Testung in der ADHS Spezialambulanz des Universitätsklinikums Frankfurt am Main vorgenommen. Mittels diagnostischer Interviews und weiteren Selbstauskunftsfragebögen (DIVA, HASE) konnte eine definitive ADHS-Diagnose gestellt und das positive Screeningergebnis verifiziert werden.
Wir stellten fest, dass die Prävalenz adulter ADHS unter Unfallopfern mit 6,89 % bzw. 8,68 % in Abhängigkeit der ASRS Auswertungskriterien im Vergleich zu der Prävalenz der adulten ADHS in der Allgemeinbevölkerung erhöht war. Des Weiteren gab es mehr Männer mit einem positiven ADHS-Screeningergebnis und einem Unfallgeschehen. Es konnten keine signifikanten geschlechtsspezifischen Unterschiede in den Unfallcharakteristika und Unfallorten in der ADHS Positivkohorte festgestellt werden. Auch in dem Vorhandensein psychischer Komorbiditäten unterschieden sich die beiden Geschlechtergruppen der ADHS-Positivkohorte nicht. Unabhängig der Geschlechterzugehörigkeit wurden die meisten Unfälle der ADHS-Positivkohorte im Straßenverkehr verzeichnet und als selbstverschuldet eingestuft. Es konnten signifikant mehr Unfälle außerhalb des Straßenverkehrs in der nicht von ADHS betroffenen Kontrollgruppe im Vergleich zu der ADHS Positivkohorte nachgewiesen werden. Insgesamt war nur bei 14 % aller positiv gescreenten Patienten eine ADHS-Erkrankung bereits bekannt und diagnostiziert worden.
Auf Grundlage der Ergebnisse dieser Studie lässt sich schlussfolgern, dass Menschen mit einer ADHS-Symptomatik vermehrt auf unfallchirurgischen Stationen anzutreffen sind und im Einklang mit früheren Forschungsergebnissen ein erhöhtes Unfall- und Verletzungsrisiko aufweisen. Darüber hinaus folgern wir aus unseren Ergebnissen, dass sich Männer und Frauen mit einer ADHS-Erkrankung hinsichtlich Symptomatik, Komorbidität und spezifischer Unfallcharakteristika ähnlicher sein könnten, als dass sie sich in diesen Bereichen unterscheiden. Im Hinblick auf die geringen vorbestehenden ADHS-Diagnosen in der Positivkohorte erscheint eine Etablierung eines Screeningsystems bei Patienten sinnvoll, die im Rahmen von Unfallgeschehen gehäuft stationär betreut werden müssen. Da ADHS-Betroffene ein erhöhtes Risiko für multiple Unfälle zu haben scheinen, könnte unter diesen Voraussetzungen eine adulte ADHS-Symptomatik früher erkannt und negative Folgen wie eine erhöhte Unfallrate reduziert werden. Methodologische Limitierungen bestanden in unserer Erhebung durch eine geringe Anzahl an ausführlichen Testungen zur Verifizierung der ADHS-Diagnose sowie dem Informationsgewinn auf der Basis einer Selbstauskunft. Um Ergebnisse aussagekräftiger zu gestalten und auch kleinere Unfälle zu erfassen, erscheint eine Ausweitung der Testung in Ambulanzen sinnvoll.
Chronic inflammation is considered to be a cause of the autoimmune diseases such as rheumatoid arthritis, Alzheimer’s disease, multiple sclerosis, etc. The search for effective compounds with anti-inflammatory properties to combat these diseases is still ongoing. Natural compound narciclasine, derived from plants of Narcissus species, demonstrated its anti-inflammatory activity in in vivo arthritis models. Further investigation of narciclasine’s anti-inflammatory activity together with its impact on the interaction between leukocytes and endothelial cells was the main focus of this PhD thesis.
Narciclasine reduced the infiltration of monocytes and neutrophils to the abdomen and the concentration of the pro-inflammatory cytokines TNF, IL-6 and IL-1β. Together with this, it reduced acute visceral pain caused by zymosan injection. Narciclasine interfered with leukocyte-endothelial cell interaction in both in vivo and in vitro models. In vivo microscopy revealed that the compound reduced rolling, adhesion and transmigration of leukocytes in the vessels of an injured murine cremaster muscle. This observation was confirmed in the in vitro models for adhesion and transmigration where narciclasine reduced the level of leukocyte’s interaction with HUVECs. Narciclasine demonstrated profound anti-inflammatory properties based on its interference with leukocyte-endothelium interaction by downregulation of endothelial cell adhesion molecules expression (ICAM-1, VCAM-1, E-selectin, CX3CL1) and shutdown of NF-κB pathway. All these effects were a result of the TNF receptor 1 protein translation blocking by narciclasine.
In this work the ability of the compound to reduce visceral pain, downregulate the expression of the endothelial cell adhesion molecules and to interfere with the interaction between leukocytes and endothelial cells was demonstrated for narciclasine for the first time. Obtained results open a promising insight into the understanding of narciclasine’s anti-inflammatory properties and justify further investigation of its potential for treatment of inflammatory diseases.
In der durchgeführten Studie erfolgte die Untersuchung des visuellen Arbeits-gedächtnisses von bipolaren Patienten im Vergleich zu gesunden Kontrollen. Es erfolgten bereits viele Untersuchungen an Patienten mit bipolarer Störung. Wird das Hauptaugenmerk auf die kognitiven Funktionen der Patienten gelegt, so konnte bereits in einigen Studien gezeigt werden, dass nicht nur in depressi-ver oder manischer, sondern auch in euthymer Stimmungslage kognitive Defizi-te vorliegen. Zur näheren Untersuchung der Funktionen des visuellen Arbeits-gedächtnisses der Patienten mit bipolarer Störung wurde daher eine fMRT-Untersuchung durchgeführt. Hier wurden Patienten, die an bipolarer Störung erkrankt sind, mit gesunden Kontrollen verglichen. Dabei wurden die bipolaren Patienten in euthymer Stimmungslage untersucht. Weder in Antwortrichtigkeit noch Reaktionsgeschwindigkeit konnte ein signifikanter Gruppenunterschied nachgewiesen werden. Außerdem wurde in der Untersuchung eine Differenzie-rung zwischen den einzelnen Phasen gemacht, die eine Gedächtnisinformation durchläuft. Bei diesen Phasen handelt es sich um Enkodierungs-, Halte- und Abrufphase. Hierbei konnten veränderte Aktivierungsmuster an diversen Hirn-strukturen der bipolaren Patienten dargestellt werden. Diese Veränderungen ziehen sich durch alle drei Phasen der Gedächtniskonsolidierung und können vor allem im präfrontalen Kortex nachgewiesen werden. Es handelt sich dabei vor allem um eine schwächere Aktivierung des präfrontalen Kortex (PFC) der bipolaren Patienten im Vergleich zu gesunden Kontrollen. Unter anderem ist das Arbeitsgedächtnis im PFC lokalisiert. Diese Ergebnisse scheinen ein Hin-weis dafür zu sein, dass bei den bipolaren Patienten neuronale Defizite im visu-ellen Arbeitsgedächtnis vorliegen.
Purpose. Status epilepticus (SE) is characterized by recurrent seizure activity and can be drug-resistant. Knowledge of neuronal and metabolic activity of the brain during SE may be helpful to improve medical care. We here report the effects of three anti-seizure drugs on changes of acetylcholine energy metabolites and oxidative stress during SE. Methods. We used the lithium-pilocarpine model in rats to induce SE and in vivo-microdialysis to monitor cholinergic and metabolic activity in the hippocampus. We measured extracellular concentrations of acetylcholine, glucose, lactate, pyruvate, glycerol and isoprostanes before and during SE, and after acute treatment with pregabalin, valproic acid, and levetiracteam. Results. Upon onset of SE, acetylcholine (ACh) release increased six- to eightfold. Glucose was increased only transiently by 30% but lactate levels rose four-fold, and extracellular concentrations of glycerol ten-fold. Isoprostanes are markers of oxidative stress and increased more than 20-fold. Two hours after pilocarpine adminstration, rats were treated with pregabalin (100 mg/kg), levetiracetam (200 mg/kg) or valproic acid (400 mg/kg) by i.p. injection. All three drugs stopped seizure activity in a delayed fashion, but at the doses indicated, only animals that received levetiracetam reached consciousness. All drugs reduced ACh release within 60-120 minutes. Lactate/pyruvate ratios, glycerol and isoprostanne levels were also reduced significantly after drug administration. Conclusions. Hippocampal ACh release closely follows seizure activity in SE and is attenuated when SE subsides. Pregabalin, valproic acid and levetiracetam all terminate seizures in the rat SE model and attenuate cholinergic and metabolic changes within two hours.