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We study the effect of the chiral symmetry restoration (CSR) on heavy-ion collisions observables in the energy range sNN=3–20GeV within the Parton-Hadron-String Dynamics (PHSD) transport approach. The PHSD includes the deconfinement phase transition as well as essential aspects of CSR in the dense and hot hadronic medium, which are incorporated in the Schwinger mechanism for particle production. Our systematic studies show that chiral symmetry restoration plays a crucial role in the description of heavy-ion collisions at sNN=3–20GeV, realizing an increase of the hadronic particle production in the strangeness sector with respect to the non-strange one. Our results provide a microscopic explanation for the horn structure in the excitation function of the K+/π+ ratio: the CSR in the hadronic phase produces the steep increase of this particle ratio up to sNN≈7GeV, while the drop at higher energies is associated to the appearance of a deconfined partonic medium. Furthermore, the appearance/disappearance of the horn structure is investigated as a function of the system size. We additionally present an analysis of strangeness production in the (T,μB)-plane (as extracted from the PHSD for central Au+Au collisions) and discuss the perspectives to identify a possible critical point in the phase diagram.
We review the results from the event-by-event next-to-leading order perturbative QCD + saturation + viscous hydrodynamics (EbyE NLO EKRT) model. With a simultaneous analysis of LHC and RHIC bulk observables we systematically constrain the QCD matter shear viscosity-to-entropy ratio η/s(T), and test the initial state computation. In particular, we study the centrality dependences of hadronic multiplicities, pT spectra, flow coefficients, relative elliptic flow fluctuations, and various flow-correlations in 2.76 and 5.02 TeV Pb+Pb collisions at the LHC and 200 GeV Au+Au collisions at RHIC. Overall, our results match remarkably well with the LHC and RHIC measurements, and predictions for the 5.02 TeV LHC run are in an excellent agreement with the data. We probe the applicability of hydrodynamics via the average Knudsen numbers in the space-time evolution of the system and viscous corrections on the freeze-out surface.
In subduction zones, sediments and hydrothermally altered oceanic crust, which together form part of the subducting slab, contribute to the chemical composition of lavas erupted at the surface to form volcanic arcs. Transport of this material from the slab to the overlying mantle wedge is thought to involve discreet melts and fluids that are released from various portions of the slab. We use a meta-analysis of geochemical data from eight globally representative arcs to show that melts and fluids from individual slab components cannot be responsible for the formation of arc lavas. Instead, the data are compatible with models that first invoke physical mixing of slab components and the mantle wedge, widely referred to as high-pressure mélange, before arc magmas are generated.
We investigated the excitation of surface plasmon polaritons on gold films with the metallized probe tip of a scattering-type scanning near-field optical microscope (s-SNOM). The emission of the polaritons from the tip, illuminated by near-infrared laser radiation, was found to be anisotropic and not circularly symmetric as expected on the basis of literature data. We furthermore identified an additional excitation channel via light that was reflected off the tip and excited the plasmon polaritons at the edge of the metal film. Our results, while obtained for a non-rotationally-symmetric type of probe tip and thus specific for this situation, indicate that when an s-SNOM is employed for the investigation of plasmonic structures, the unintentional excitation of surface waves and anisotropic surface wave propagation must be considered in order to correctly interpret the signatures of plasmon polariton generation and propagation.
We study anisotropic fluid dynamics derived from the Boltzmann equation based on a particular choice for the anisotropic distribution function within a boost-invariant expansion of the fluid in one spatial dimension. In order to close the conservation equations we need to choose an additional moment of the Boltzmann equation. We discuss the influence of this choice of closure on the time evolution of fluid-dynamical variables and search for the best agreement to the solution of the Boltzmann equation in the relaxation-time approximation.
GPR116 (ADGRF5) and ELTD1 (ADGRL4) belong to different subfamilies of the adhesion G-protein-coupled receptor group but are both expressed in endothelial cells. We therefore analyzed their functions in mice lacking these receptors. While loss of GPR116 or ELTD1 alone had no obvious effect on cardiovascular or kidney function, mice lacking both, GPR116 and ELTD1, showed malformations of the aortic arch arteries and the cardiac outflow tract leading to perinatal lethality in about 50% of the mutants. In addition to cardiovascular malformations, surviving mice developed renal thrombotic microangiopathy as well as hemolysis and splenomegaly, and their lifespan was significantly reduced. Loss of GPR116 and ELTD1 specifically in endothelial cells or neural crest-derived cells did not recapitulate any of the phenotypes observed in GPR116-ELTD1 double deficient mice, indicating that loss of GPR116 and ELTD1 expressed by other cells accounts for the observed cardiovascular and renal defects.
Paricalcitol is approved for prevention and therapy of secondary hyperparathyroidism (sHPT) in patients with chronic kidney disease (CKD), with only short-term data in clinical routine settings. A 12-month observational study was conducted in Germany and Austria (90 centers, 761 patients) from 2008 to 2013. Laboratory values, demographical, and clinical data were documented in 629 dialysis patients and 119 predialysis patients. In predialysis patients, median intact parathormone (iPTH) was 180.0 pg/mL (n = 105) at the start of the study, 115.7 pg/mL (n = 105) at last documentation, and 151.8 pg/mL (n = 50) at month 12, with 32.4% of the last documented iPTH values in the KDOQI (Kidney Disease Outcomes Quality Initiative) target range. In dialysis patients, median iPTH was 425.5 pg/mL (n = 569) at study start, 262.3 pg/mL (n = 569) at last documentation, and 266.1 pg/mL (n = 318) at month 12, with 36.5% of dialysis patients in the KDOQI target range. Intravenous paricalcitol showed more homogenous iPTH control than oral treatment. Combined analysis of all dialysis patients indicated comparable and stable mean serum calcium and phosphate levels throughout the study. Clinical symptoms, such as itching, bone pain, and fatigue, were improved compared with study entry. The spectrum and frequency of adverse events mirrored the known pattern for patients on dialysis. Paricalcitol is efficacious and has a consistent safety profile in sHPT over 12 months.
Background: Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli. They play important roles in the pain pathway where in concert with proinflammatory factors such as leukotrienes they mediate sensitization and hyperalgesia. TRPV1 is the target of several novel analgesics drugs under development and therefore, TRPV1 genetic variants might represent promising candidates for pharmacogenetic modulators of drug effects.
Methods: A next-generation sequencing (NGS) panel was created for the human TRPV1 gene and in addition, for the leukotriene receptors BLT1 and BLT2 recently described to modulate TRPV1 mediated sensitisation processes rendering the coding genes LTB4R and LTB4R2 important co-players in pharmacogenetic approaches involving TRPV1. The NGS workflow was based on a custom AmpliSeq™ panel and designed for sequencing of human genes on an Ion PGM™ Sequencer. A cohort of 80 healthy subjects of Western European descent was screened to evaluate and validate the detection of exomic sequences of the coding genes with 25 base pair exon padding.
Results: The amplicons covered approximately 97% of the target sequence. A median of 2.81 x 10 6 reads per run was obtained. This identified approximately 140 chromosome loci where nucleotides deviated from the reference sequence GRCh37 hg19 comprising the three genes TRPV1, LTB4R and LTB4R2. Correspondence between NGS and Sanger derived nucleotide sequences was 100%.
Conclusions: Results suggested that the NGS approach based on AmpliSeq™ libraries and Ion Personal Genome Machine (PGM) sequencing is a highly efficient mutation detection method. It is suitable for large-scale sequencing of TRPV1 and functionally related genes. The method adds a large amount of genetic information as a basis for complete analysis of TRPV1 ion channel genetics and its functional consequences.
Objective: The aim of this study was to evaluate and compare the efficacy of single-treatment cooled and uncooled microwave ablation in thyroid nodules.
Methods: Eighteen patients (11 women) with an average age of 62 years (range: 41–80) with 18 cold, mainly solid or solid thyroid nodules were treated with cooled or uncooled microwave ablation. Pain during the treatment was measured on a 10-point score. Side effects revealed by ultrasound or patients’ complaints were documented. Laboratory data was evaluated before, 24 h and three months after MWA. Nodule volumes were measured before and three months after MWA.
Results: Cooled MWA was better tolerated than uncooled MWA. A significant reduction of thyroid nodule volume was observed in all cases. The reduction after cMWA was higher (40%) than after uMWA (29%). Pain intensity during cMWA was significantly lower than after uMWA. CMWA and uMWA led to a significant decrease of nodule blood circulation and echogenicity and to a significant increase of nodule elasticity. Thyroid function remained intact in all cases. The energy (kJ/s) administered into the nodules in relation to the ablation time during cMWA was higher than during uMWA.
Conclusions: CMWA leads to a slightly higher but statistically not significant nodule volume reduction than uMWA. Patient comfort during cMWA is higher than during uMWA. The risk of unintended side effects is less in cMWA. A Single-treatment provides sufficient results.
Sex differences in the relationship between conduct disorder and cortical structure in adolescents
(2017)
Objective: Previous studies have reported reduced cortical thickness and surface area and altered gyrification in frontal and temporal regions in adolescents with conduct disorder (CD). Although there is evidence that the clinical phenotype of CD differs between males and females, no studies have examined whether such sex differences extend to cortical and subcortical structure.
Method: As part of a European multisite study (FemNAT-CD), structural magnetic resonance imaging (MRI) data were collected from 48 female and 48 male participants with CD and from 104 sex-, age-, and pubertal-status−matched controls (14–18 years of age). Data were analyzed using surface-based morphometry, testing for effects of sex, diagnosis, and sex-by-diagnosis interactions, while controlling for age, IQ, scan site, and total gray matter volume.
Results: CD was associated with cortical thinning and higher gyrification in ventromedial prefrontal cortex in both sexes. Males with CD showed lower, and females with CD showed higher, supramarginal gyrus cortical thickness compared with controls. Relative to controls, males with CD showed higher gyrification and surface area in superior frontal gyrus, whereas the opposite pattern was seen in females. There were no effects of diagnosis or sex-by-diagnosis interactions on subcortical volumes. Results are discussed with regard to attention-deficit/hyperactivity disorder, depression, and substance abuse comorbidity, medication use, handedness, and CD age of onset.
Conclusion: We found both similarities and differences between males and females in CD–cortical structure associations. This initial evidence that the pathophysiological basis of CD may be partly sex-specific highlights the need to consider sex in future neuroimaging studies and suggests that males and females may require different treatments.
Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior. Here we investigated the relationship between callous-unemotional traits and gray matter volume using voxel-based morphometry in a large sample of typically-developing boys and girls (N = 189). Whole-brain multiple regression analyses controlling for site, total intracranial volume, and age were conducted in the whole sample and in boys and girls individually. Results revealed that sex and callous-unemotional traits interacted to predict gray matter volume when considering the whole sample. This interaction was driven by a significant positive correlation between callous-unemotional traits and bilateral anterior insula volume in boys, but not girls. Insula gray matter volume explained 19% of the variance in callous-unemotional traits for boys. Our results demonstrate that callous-unemotional traits are related to variations in brain structure beyond psychiatric samples. This association was observed for boys only, underlining the importance of considering sex as a factor in future research designs. Future longitudinal studies should determine whether these findings hold over childhood and adolescence, and whether the neuroanatomical correlates of callous-unemotional traits are predictive of future psychiatric vulnerability.
Razina pročišćenosti alogenoga koštanog bloka = Variant purification of an allogeneic bone block
(2017)
Svrha: Ovaj kratak tekst izvještava o histološkoj analizi sastava komercijalno raspoloživih alogenih koštanih blokova Maxgraft®. Materijali i metode: Na temelju objavljenih histoloških metoda prazni uzorci alogenih koštanih blokova Maxgraft® dekalcificirani su, dehidrirani i uloženi u parafin prije histološkog i histokemijskog bojenja. Nakon toga na prerezima su se procjenjivala obilježja materijala, poput strukture koštanoga matriksa i druge komponente, uključujući kolagen ili stanice/stanične ostatke. Rezultati: Uočeno je da ovi koštani blokovi imaju trabekularnu strukturu s lamelarnom podorganizacijom. Dodatno su nađeni i stanični ostatci unutar lakuna osteocita i na vanjskim površinama trabekula zajedno s ostatcima intertrabekularnog masnog i vezivnog tkiva, te kolagene strukture, vezivno-tkivne stanice i stanični ostatci. Zaključak: U skladu s dosadašnjim istraživanjima, podatci iz ovoga teksta pokazuju da neke od certificiranih tehnika pročišćavanja ne omogućuju proizvodnju alogenog materijala bez organskih stanica i tkivnih komponenata.
Der viel diskutierte Begriff der "Multinormativität" steht heute in Konkurrenz zu dem des "Rechtspluralismus" und der "Diversität" des Rechts. Alle drei Begriffe verfügen nicht über eine inhaltliche und funktionale Eindeutigkeit und zeigen kein bestimmtes Verhältnis zu- und untereinander. Eine sehr vage Gemeinsamkeit solcher "Rechtspluralitäten" besteht allein in deren Unterscheidung oder Abweichung vom Gegenbegriff einer "Rechtseinheit" bzw. der ideal gedachten Einheit der Rechtsordnung, wie sie von den Kodifikatoren des Privatrechts im Zeitalter der Aufklärung versucht wurde zu verwirklichen. In einem solchen Spannungsverhältnis zwischen Einheitlichkeit oder Vielfalt gesellschaftlicher und staatlicher Rechtsgestaltung steht jedes organisierte Gemeinwesen. Das ist eine historische Erfahrung, die sich seit der römischen Antike in der rechtssystematischen Einteilung in ein "ius universale " und "ius speciale/particulare" zeigt. In der aktuellen Diskussion scheint "Multinormativität" als der umfassendere Begriff für die Rechtevielfalt gebraucht zu werden. In der rechtstheoretisch orientierten Literatur kann man je nach disziplinärer Einteilung bis zu sieben "Rechtspluralismen" unterscheiden, die die Definitionsnot und sprachliche Bedeutungsvielfalt nachdrücklich belegen. Dieser "Pluralismus" kann durch Rechte oder auch "Rechts-Ordnungen" in der Interaktion zwischen einer herrschenden und einer alternativen "Rechts-Ordnung" bestimmt sein. Die Konkretisierungsbedürftigkeit von "Rechtspluralismus" und "Multinormativität" haben diese beiden Begriffe auch gemeinsam mit dem geläufigen Nachbarbegriff der pluralen "Rechtsquellen", die als Sammelbezeichnung für die Grundlagen rechtlicher Entscheidungen fungieren. Multinormativität kann heute als eine extensive Variante von "Rechtsquellenvielfalt" oder "Rechtsvielfalt" gesehen werden, beschränkt sich jedoch nicht auf die Dimension der rechtlichen Entscheidungsgrundlagen, sondern erweitert diese auch auf die Vielzahl möglicher außerrechtlicher entscheidungsrelevanter "Normen". Das ist der Grund, weshalb heute der Begriff des "normative pluralism" dem des "legal pluralism" vorgezogen wird, um auch das "phenomenon of law beyond the state" in den Griff zu bekommen. In der deutschen Literatur ist heute das beliebte Bild und der vielgebrauchte Begriff der "Rechtsquellen" höchst umstritten, da in ihm mehr das "fließende" Element höchst mobiler rechtlicher Ordnungsinstrumente zum Ausdruck kommt als die Bestimmtheit und Sicherheit rechtlicher Normangebote. Luhmann bezeichnete die eine Rechtspluralität indizierende Rechtsquellenlehre als ein "mehrschichtiges Theoriegebäude mit schwankenden Fundamenten" und Esser sprach sogar von den "doktrinären Peinlichkeiten", vor die sich die Rechtsquellenlehre gestellt sah und gestellt sieht. Multinormativität löst heute weitgehend den "Rechtsquellen"-Begriff ab, indem er ihn vor dem Hintergrund internationaler politischer Praxis und Erfahrungen überlagert und ausweitet. ...
Wolfgang Burgdorf (B), Historiker für Neuere Geschichte an der Universität München und Autor zahlreicher Arbeiten über das Alte Reich, hat 2015 zwei wichtige Bände vorgelegt, deren Thematik sich zwischen Geschichte und Verfassung des Alten Reiches bewegt. Grundlage und Prüfungsfall für die juristische "Verfassung" des Alten Reiches bilden die 17 Wahlkapitulationen, die von 1519 bis 1792 zwischen dem jeweiligen kaiserlichen Thronkandidaten und dem kurfürstlichen Wählerkollegium vereinbart wurden, sowie das "Projekt einer beständigen Wahlkapitulation vom 8. Juli 1711". Diese 18 Texte hat B. im erstgenannten Band ediert, mit dem zugleich eine neue Reihe "Quellen zur Geschichte des Heiligen Römischen Reiches" eröffnet wird, herausgegeben durch Heinz Duchhardt von der Historischen Kommission bei der Bayerischen Akademie der Wissenschaften. Die Geschichte des Alten Reiches verdient als ein "staatliches" Gebilde sui generis, das der Staatsformenlehre zur Bestimmung seiner Verfassungsqualität immer große Schwierigkeiten bereitet hat, weiterhin alle wissenschaftliche Aufmerksamkeit und man darf gespannt sein, welche "Quellen" demnächst noch in dieser Reihe veröffentlicht werden. Der zweite, zeitgleich erschienene Band mit dem problematischen Titel "Protokonstitutionalismus" steht mit dem Editionsband gleichsam in einem Fortsetzungszusammenhang, in dem B. versucht, eine umfassende Analyse und Interpretation der alten Reichsverfassung auf der Grundlage der edierten Wahlkapitulationen zu bieten. ...
Coming early to the party
(2017)
We examine the strategic behavior of High Frequency Traders (HFTs) during the pre-opening phase and the opening auction of the NYSE-Euronext Paris exchange. HFTs actively participate, and profitably extract information from the order flow. They also post "flash crash" orders, to gain time priority. They make profits on their last-second orders; however, so do others, suggesting that there is no speed advantage. HFTs lead price discovery, and neither harm nor improve liquidity. They "come early to the party", and enjoy it (make profits); however, they also help others enjoy the party (improve market quality) and do not have privileges (their speed advantage is not crucial).
We present the black hole accretion code (BHAC), a new multidimensional general-relativistic magnetohydrodynamics module for the MPI-AMRVAC framework. BHAC has been designed to solve the equations of ideal general-relativistic magnetohydrodynamics in arbitrary spacetimes and exploits adaptive mesh refinement techniques with an efficient block-based approach. Several spacetimes have already been implemented and tested. We demonstrate the validity of BHAC by means of various one-, two-, and three-dimensional test problems, as well as through a close comparison with the HARM3D code in the case of a torus accreting onto a black hole. The convergence of a turbulent accretion scenario is investigated with several diagnostics and we find accretion rates and horizon-penetrating fluxes to be convergent to within a few percent when the problem is run in three dimensions. Our analysis also involves the study of the corresponding thermal synchrotron emission, which is performed by means of a new general-relativistic radiative transfer code, BHOSS. The resulting synthetic intensity maps of accretion onto black holes are found to be convergent with increasing resolution and are anticipated to play a crucial role in the interpretation of horizon-scale images resulting from upcoming radio observations of the source at the Galactic Center.
Die weltweiten Migrationsbewegungen gehören zu den größten Herausforderungen unserer Zeit. Sie resultieren aus sozialen Konflikten und bringen ihrerseits gesellschaftliche Veränderungen hervor. Die neunte Internationale Jahreskonferenz des Exzellenzclusters „Die Herausbildung normativer Ordnungen“ nahm dieses Wechselspiel aus einer interdisziplinären, empirischen und normativen Perspektive in den Blick und fragte dabei insbesondere nach den Herausforderungen an die Politik und den gewandelten Konzepten nationaler Grenzen. Die zweitägige Konferenz fand Ende November im Gebäude des Clusters auf dem Campus Westend statt. Das Thema lautete: „Normative (B)Orders. Migration and Citizenship in a Time of Crisis“
Die Stiftung Polytechnische Gesellschaft vergibt Stipendien an herausragende Nachwuchswissenschaftler, die Lust haben, über den eigenen Tellerrand zu schauen,