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Both the genomes of the epsilonproteobacteria Wolinella succinogenes and Campylobacter jejuni contain operons (sdhABE) that encode for so far uncharacterized enzyme complexes annotated as ‘non-classical’ succinate:quinone reductases (SQRs). However, the role of such an enzyme ostensibly involved in aerobic respiration in an anaerobic organism such as W. succinogenes has hitherto been unknown. We have established the first genetic system for the manipulation and production of a member of the non-classical succinate:quinone oxidoreductase family. Biochemical characterization of the W. succinogenes enzyme reveals that the putative SQR is in fact a novel methylmenaquinol:fumarate reductase (MFR) with no detectable succinate oxidation activity, clearly indicative of its involvement in anaerobic metabolism. We demonstrate that the hydrophilic subunits of the MFR complex are, in contrast to all other previously characterized members of the superfamily, exported into the periplasm via the twin-arginine translocation (tat)-pathway. Furthermore we show that a single amino acid exchange (Ala86→His) in the flavoprotein of that enzyme complex is the only additional requirement for the covalent binding of the otherwise non-covalently bound FAD. Our results provide an explanation for the previously published puzzling observation that the C. jejuni sdhABE operon is upregulated in an oxygen-limited environment as compared with microaerophilic laboratory conditions.
Perturbation theory for non-abelian gauge theories at finite temperature is plagued by infrared
divergences which are caused by magnetic soft modes ~ g2T, corresponding to gluon fields of
a 3d Yang-Mills theory. While the divergences can be regulated by a dynamically generated
magnetic mass on that scale, the gauge coupling drops out of the effective expansion parameter
requiring summation of all loop orders for the calculation of observables. Some gauge invariant
possibilities to implement such infrared-safe resummations are reviewed. We use a scheme based
on the non-linear sigma model to estimate some of the contributions ~ g6 of the soft magnetic
modes to the QCD pressure through two loops. The NLO contribution amounts to ~ 10% of the
LO, suggestive of a reasonable convergence of the series.
The so-called sign problem of lattice QCD prohibits Monte Carlo simulations at finite baryon
density by means of importance sampling. Over the last few years, methods have been developed
which are able to circumvent this problem as long as the quark chemical potential is m=T <~1.
After a brief review of these methods, their application to a first principles determination of the
QCD phase diagram for small baryon densities is summarised. The location and curvature of the
pseudo-critical line of the quark hardon transition is under control and extrapolations to physical
quark masses and the continuum are feasible in the near future. No definite conclusions can as
yet be drawn regarding the existence of a critical end point, which turns out to be extremely quark
mass and cut-off sensitive. Investigations with different methods on coarse lattices show the lightmass
chiral phase transition to weaken when a chemical potential is switched on. If persisting on
finer lattices, this would imply that there is no chiral critical point or phase transition for physical
QCD. Any critical structure would then be related to physics other than chiral symmetry breaking.
The chiral critical surface is a surface of second order phase transitions bounding the region of
first order chiral phase transitions for small quark masses in the fmu;d;ms;mg parameter space.
The potential critical endpoint of the QCD (T;m)-phase diagram is widely expected to be part of
this surface. Since for m = 0 with physical quark masses QCD is known to exhibit an analytic
crossover, this expectation requires the region of chiral transitions to expand with m for a chiral
critical endpoint to exist. Instead, on coarse Nt = 4 lattices, we find the area of chiral transitions
to shrink with m, which excludes a chiral critical point for QCD at moderate chemical potentials
mB < 500 MeV. First results on finer Nt = 6 lattices indicate a curvature of the critical surface
consistent with zero and unchanged conclusions. We also comment on the interplay of phase
diagrams between the Nf = 2 and Nf = 2+1 theories and its consequences for physical QCD.
We perform a two-flavor dynamical lattice computation of the Isgur-Wise functions t1/2 and t3/2
at zero recoil in the static limit. We find t1/2(1) = 0.297(26) and t3/2(1) = 0.528(23) fulfilling
Uraltsev’s sum rule by around 80%. We also comment on a persistent conflict between theory and
experiment regarding semileptonic decays of B mesons into orbitally excited P wave D mesons,
the so-called “1/2 versus 3/2 puzzle”, and we discuss the relevance of lattice results in this
context.