Paraneoplastic cerebellar degeneration associated with lymphoepithelial carcinoma of the tonsil

  • Background: Paraneoplastic cerebellar degeneration (PCD) is a classical tumor-associated, immune-mediated disease typically associated with gynecological malignancies, small-cell lung-cancer or lymphoma. Case presentation: Here we present the case of a 38-year old male with an over 12 months rapidly progressive cerebellar syndrome. Extensive diagnostic workup revealed selective hypermetabolism of the right tonsil in whole-body PET. Histological examination after tonsillectomy demonstrated a lymphoepithelial carcinoma of the tonsil and the tongue base strongly suggesting a paraneoplastic cause of the cerebellar syndrome. To the best of our knowledge this is the first case of an association of a lymphoepithelial carcinoma, a rare pharyngeal tumor, with PCD. Conclusions: In cases of classical paraneoplastic syndromes an extensive search for neoplasms should be performed including whole-body PET to detect tumors early in the course of the disease.

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Author:Christian Henke, Johannes RiegerGND, Sylvia HartmannORCiDGND, Marcus Middendorp, Helmuth SteinmetzORCiDGND, Ulf ZiemannORCiDGND
Pubmed Id:
Parent Title (English):BMC neurology
Publisher:BioMed Central ; Springer
Place of publication:London ; Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2013/10/31
Date of first Publication:2013/10/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/10/31
Tag:Lymphoepithelioma; PET; Paraneoplastic syndrome; Subacute cerebellar degeneration; Tonsil
Page Number:4
First Page:1
Last Page:4
© 2013 Henke et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 2.0