Closing gaps in brain disease — from overlapping genetic architecture to common motifs of synapse dysfunction

  • Recent progress in the synaptic pathophysiology of brain diseases is reviewed. To emphasize the emergence of common motifs in synapse dysfunctions across neurodevelopmental, psychiatric and neurological disorders, conventional clinical boundaries are disregarded and a decidedly trans-diagnostic, potentially unifying view of altered synapse function is promoted. Based on the overlapping genetic architecture of brain disorders, which often converges on genes related to synaptic functions, disease-related changes in basic pre-synaptic and post-synaptic communication, neuromodulation-gated changes in Hebbian plasticity, dynamic interactions between Hebbian and homeostatic plasticity, and changes in synaptic maintenance by autophagy and glial-mediated phagocytosis are highlighted.

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Author:Jochen RoeperORCiD
Pubmed Id:
Parent Title (English):Current opinion in neurobiology
Publisher:Current Biology
Place of publication:Philadelphia, Pa.
Contributor(s):Claudia Bagni, Anatol Kreitzer
Document Type:Article
Year of Completion:2017
Date of first Publication:2017/09/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/03/21
Page Number:7
First Page:45
Last Page:51
© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0