Epigenetic inheritance of cell fates during embryonic development

  • During embryonic development a large number of widely differing and specialized cell types with identical genomes are generated from a single totipotent zygote. Tissue specific transcription factors cooperate with epigenetic modifiers to establish cellular identity in differentiated cells and epigenetic regulatory mechanisms contribute to the maintenance of distinct chromatin states and cell-type specific gene expression patterns, a phenomenon referred to as epigenetic memory. This is accomplished via the stable maintenance of various epigenetic marks through successive rounds of cell division. Preservation of DNA methylation patterns is a well-established mechanism of epigenetic memory, but more recently it has become clear that many other epigenetic modifications can also be maintained following DNA replication and cell division. In this review, we present an overview of the current knowledge regarding the role of histone lysine methylation in the establishment and maintenance of stable epigenetic states.

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Author:Sirisha Cheedipudi, Oriana Genolet, Gergana Dobreva
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/24550937
Parent Title (English):Frontiers in genetics
Publisher:Frontiers Media
Place of publication:Lausanne
Contributor(s):Yonggang Zhou
Document Type:Article
Year of Completion:2014
Date of first Publication:2014/02/04
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/12/23
Tag:ES cells; cell fate; cell identity; epigenetic memory; epigenetics; histone modification; inheritance
Issue:Art. 19
Page Number:7
First Page:1
Last Page:7
Copyright © 2014 Cheedipudi, Genolet and Dobreva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0