Histopathological growth patterns in patients with advanced nodular lymphocyte-predominant Hodgkin lymphoma treated within the randomized HD18 study: a report from the German Hodgkin Study Group

  • We retrospectively investigated histopathological growth patterns in individuals with advanced nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) treated within the randomized HD18 study. In all, 35/60 patients (58%) presented with atypical growth patterns. Patients with atypical growth patterns more often had stage IV disease (P = 0·0354) and splenic involvement (P = 0·0048) than patients with typical growth patterns; a positive positron emission tomography after two cycles of chemotherapy (PET-2) tended to be more common (P = 0·1078). Five-year progression-free survival [hazard ratio (HR) = 0·86; 95% confidence interval (CI) = 0·49–1·47] and overall survival (HR = 0·85; 95% CI = 0·49–1·51) did not differ between the groups after study treatment with PET-2-guided escalated BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone). Thus, advanced NLPHL is often associated with atypical growth patterns but their prognostic impact is compensated by PET-2-guided escalated BEACOPP.
Author:Dennis Alexander Eichenauer, Ina Bühnen, Stefanie Kreissl, Helen Goergen, Michael Fuchs, Bastian von Tresckow, Andreas RosenwaldGND, Wolfram Klapper, Martin-Leo HansmannGND, Peter Möller, Heinz-Wolfram BerndGND, Alfred C. Feller, Andreas Engert, Peter Borchmann, Sylvia HartmannORCiDGND
Parent Title (English):British journal of haematology
Place of publication:Oxford [u.a.]
Document Type:Article
Date of Publication (online):2021/08/15
Date of first Publication:2021/08/15
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/03/10
Tag:BEACOPP; histopathological growth pattern; interim positron emissiontomography; nodular lymphocyte-predominant Hodgkin lymphoma
Page Number:6
First Page:99
Last Page:104
SH is supported by the Deutsche Forschungsgemeinschaft (grant HA6145/3-1).
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0