Hepatitis C-associated B-cell non-Hodgkin lymphomas. Epidemiology, molecular signature and clinical management
- There is ample epidemiologic evidence for an association of chronic hepatitis C virus (HCV) infection with B-cell non-Hodgkin lymphoma (B-NHL). B-NHL subtypes most frequently associated with HCV are marginal zone lymphoma and diffuse large B-cell lymphoma. The most convincing evidence for a causal relationship between HCV infection and lymphoma development is the observation of B-NHL regression after HCV eradication by antiviral therapy (AVT). In fact, for indolent HCV-associated B-NHL, first-line AVT instead of standard immune-chemotherapy might be considered. Molecular mechanisms of HCV-NHL development are still poorly understood. Three general theories have emerged to understand the HCV-induced lymphomagenesis: (1) continuous external stimulation of lymphocyte receptors by viral antigens and consecutive proliferation; (2) HCV replication in B cells with oncogenic effect mediated by intracellular viral proteins; (3) permanent B-cell damage, e.g., mutation of tumor suppressor genes, caused by a transiently intracellular virus (“hit and run” theory). This review systematically summarizes the data on epidemiology, interventional studies, and molecular mechanisms of HCV-associated B-NHL.
Verfasserangaben: | Jan Franz-Josef Peveling-OberhagORCiDGND, Luca ArcainiORCiD, Martin-Leo HansmannGND, Stefan ZeuzemORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-768720 |
DOI: | https://doi.org/10.1016/j.jhep.2013.03.018 |
ISSN: | 0168-8278 |
Titel des übergeordneten Werkes (Englisch): | Journal of hepatology |
Verlag: | Elsevier |
Verlagsort: | Amsterdam |
Dokumentart: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Veröffentlichung (online): | 27.03.2013 |
Datum der Erstveröffentlichung: | 27.03.2013 |
Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Datum der Freischaltung: | 27.11.2023 |
Freies Schlagwort / Tag: | Antiviral therapy; B-cell; Hepatitis C; Lymphoma; Non-Hodgkin lymphoma |
Jahrgang: | 59 |
Ausgabe / Heft: | 1 |
Seitenzahl: | 9 |
Erste Seite: | 169 |
Letzte Seite: | 177 |
HeBIS-PPN: | 516557629 |
Institute: | Medizin |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Lizenz (Deutsch): | Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |