Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila
- Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry. We discovered distinct age-related changes in both model organisms. Mitochondrial function and ultrastructure are maintained in mouse heart, whereas subpopulations of mitochondria from mouse liver show age-related changes in membrane morphology. Subpopulations of mitochondria from young and old mouse kidney resemble those described for apoptosis. In aged flies, respiratory activity is compromised and the production of peroxide radicals is increased. In about 50% of mitochondria from old flies, the inner membrane organization breaks down. This establishes a clear link between inner membrane architecture and functional decline. Mitochondria were affected by ageing to very different extents, depending on the organism and possibly on the degree to which tissues within the same organism are protected against mitochondrial damage.
Author: | Tobias Brandt, Arnaud Mourier, Luke S. Tain, Linda Partridge, Nils-Göran Larsson, Werner KühlbrandtORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-444368 |
DOI: | https://doi.org/10.7554/eLife.24662 |
ISSN: | 2050-084X |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28699890 |
Parent Title (English): | eLife |
Publisher: | eLife Sciences Publications |
Place of publication: | Cambridge |
Contributor(s): | Sriram Subramaniam |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2017/09/04 |
Date of first Publication: | 2017/07/12 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2017/09/04 |
Tag: | D. melanogaster; ageing; biochemistry; biophysics; cryo-tomography; membrane structure; mitochondrial inner membrane; mouse; peroxide radicals; respiratory activity; structural biology |
Volume: | 6 |
Page Number: | 19 |
First Page: | 1 |
Last Page: | 19 |
Note: | Copyright Brandt et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
HeBIS-PPN: | 424951037 |
Institutes: | Angeschlossene und kooperierende Institutionen / MPI für Biophysik |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 59 Tiere (Zoologie) / 590 Tiere (Zoologie) |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |