The regulation of synaptic protein turnover
- Emerging evidence indicates that protein synthesis and degradation are necessary for the remodeling of synapses. These two processes govern cellular protein turnover, are tightly regulated, and are modulated by neuronal activity in time and space. The anisotropic anatomy of the neurons presents a challenge for the study of protein turnover, but the understanding of protein turnover in neurons and its modulation in response to activity can help us to unravel the fine-tuned changes that occur at synapses in response to activity. Here we review the key experimental evidence demonstrating the role of protein synthesis and degradation in synaptic plasticity, as well as the turnover rates of specific neuronal proteins.
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| Author: | Beatriz Alvarez-CastelaoORCiD, Erin M. SchumanORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-759250 |
| DOI: | https://doi.org/10.1074/jbc.R115.657130 |
| ISSN: | 0021-9258 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/26453306 |
| Parent Title (English): | Journal of biological chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology Publications |
| Place of publication: | Bethesda, Md |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2021/01/04 |
| Year of first Publication: | 2015 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/11/14 |
| Tag: | neuron; protein degradation; protein synthesis; protein turnover; synapse; synaptic plasticity |
| Volume: | 290 |
| Issue: | 48 |
| Page Number: | 8 |
| First Page: | 28623 |
| Last Page: | 28630 |
| HeBIS-PPN: | 516505475 |
| Institutes: | Angeschlossene und kooperierende Institutionen / MPI für Hirnforschung |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
| 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY - Namensnennung 4.0 International |
