- Objective: Trauma is the most common cause of death among young adults. Alcohol intoxication plays a significant role as a cause of accidents and as a potent immunomodulator of the post-traumatic response to tissue injury. Polytraumatized patients are frequently at risk to developing infectious complications, which may be aggravated by alcohol-induced immunosuppression. Systemic levels of integral proteins of the gastrointestinal tract such as syndecan-1 or intestinal fatty acid binding proteins (FABP-I) reflect the intestinal barrier function. The exact impact of acute alcohol intoxication on the barrier function and endotoxin bioactivity have not been clarified yet. Methods: 22 healthy volunteers received a precisely defined amount of alcohol (whiskey–cola) every 20 min over a period of 4 h to reach the calculated blood alcohol concentration (BAC) of 1‰. Blood samples were taken before alcohol drinking as a control, and after 2, 4, 6, 24 and 48 h after beginning with alcohol consumption. In addition, urine samples were collected. Intestinal permeability was determined by serum and urine values of FABP-I, syndecan-1, and soluble (s)CD14 as a marker for the endotoxin translocation via the intestinal barrier by ELISA. BAC was determined. Results: Systemic FABP-I was significantly reduced 2 h after the onset of alcohol drinking, and remained decreased after 4 h. However, at 6 h, FABP-I significantly elevated compared to previous measurements as well as to controls (p < 0.05). Systemic sCD14 was significantly elevated after 6, 24 and 48 h after the onset of alcohol consumption (p < 0.05). Systemic FABP-I at 2 h after drinking significantly correlated with the sCD14 concentration after 24 h indicating an enhanced systemic LPS bioactivity. Women showed significantly lower levels of syndecan-1 in serum and urine and urine for all time points until 6 h and lower FABP-I in the serum after 2 h. Conclusions: Even relative low amounts of alcohol affect the immune system of healthy volunteers, although these changes appear minor in women. A potential damage to the intestinal barrier and presumed enhanced systemic endotoxin bioactivity after acute alcohol consumption is proposed, which represents a continuous immunological challenge for the organism and should be considered for the following days after drinking.
MetadatenAuthor: | Ramona SturmGND, Florian HaagGND, Andrea JanicováGND, Baolin XuGND, Jan Tilmann VollrathORCiDGND, Katrin BundkirchenORCiD, Ildikò Rita DunayORCiDGND, Claudia NeunaberORCiDGND, Ingo MarziORCiDGND, Borna ReljaORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-636410 |
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DOI: | https://doi.org/10.1007/s00068-021-01666-4 |
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ISSN: | 1863-9941 |
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Parent Title (English): | European journal of trauma and emergency surgery |
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Publisher: | Springer Medizin |
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Place of publication: | Heidelberg |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2021/04/11 |
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Date of first Publication: | 2021/04/11 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2022/08/16 |
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Tag: | Alcohol; Barrier; FABP; Gender; SCD14; Syndecan-1 |
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Volume: | 48.2021 |
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Issue: | 3 |
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Page Number: | 9 |
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First Page: | 1569 |
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Last Page: | 1577 |
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Note: | Open Access funding enabled and organized by Projekt DEAL. The study was supported by grants from the Deutsche Forschungsgemeinschaft (grant nos. DFG RE 3304/5-1, DFG RE 3304/9-1, DFG NE 1932/1-3 and Nachwuchsförderung AO Trauma Deutschland (R.S.). |
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HeBIS-PPN: | 505047586 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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