Cyclic nucleotide (cNMP) analogues: past, present and future
- Cyclic nucleotides are important second messengers involved in cellular events, and analogues of this type of molecules are promising drug candidates. Some cyclic nucleotide analogues have become standard tools for the investigation of biochemical and physiological signal transduction pathways, such as the Rp-diastereomers of adenosine and guanosine 3′,5′-cyclic monophosphorothioate, which are competitive inhibitors of cAMP- and cGMP-dependent protein kinases. Next generation analogues exhibit a higher membrane permeability, increased resistance against degradation, and improved target specificity, or are caged or photoactivatable for fast and/or targeted cellular imaging. Novel specific nucleotide analogues activating or inhibiting cyclic nucleotide-dependent ion channels, EPAC/GEF proteins, and bacterial target molecules have been developed, opening new avenues for basic and applied research. This review provides an overview of the current state of the field, what can be expected in the future and some practical considerations for the use of cyclic nucleotide analogues in biological systems.
Author: | Erik MarondeORCiDGND |
---|---|
URN: | urn:nbn:de:hebis:30:3-814754 |
DOI: | https://doi.org/10.3390/ijms222312879 |
ISSN: | 1422-0067 |
Parent Title (English): | International journal of molecular sciences |
Publisher: | Molecular Diversity Preservation International |
Place of publication: | Basel |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/11/28 |
Date of first Publication: | 2021/11/28 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/01/22 |
Tag: | 2′,3′-cGAMP; cAMP; cGMP; cyclic nucleotide analogues; cyclic nucleotide binding proteins |
Volume: | 22 |
Issue: | 23, art. 12879 |
Article Number: | 12879 |
Page Number: | 11 |
First Page: | 1 |
Last Page: | 11 |
Note: | This work was supported by basic funding by the Senckenbergische Anatomie, Medical Faculty of the Goethe University, Frankfurt, Germany. |
Institutes: | Medizin |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie | |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |