Robert Benedikt Höh, Mike Wenzel, Matthias Müller, Clarissa Wittler, Eva Schlenke, Jan L. Hohenhorst, Jens Köllermann, Thomas Steuber, Markus Graefen, Derya Tilki, Simon Bernatz, Pierre I. Karakiewicz, Felix Preißer, Andreas Becker, Luis Kluth, Philipp Mandel, Felix Chun
- Background: To test the impact of urethral sphincter length (USL) and anatomic variants of prostatic apex (Lee-type classification) in preoperative multiparametric magnet resonance imaging (mpMRI) on mid-term continence in prostate cancer patients treated with radical prostatectomy (RP). Methods: We relied on an institutional tertiary-care database to identify patients who underwent RP between 03/2018 and 12/2019 with preoperative mpMRI and data available on mid-term (>6 months post-surgery) urinary continence, defined as usage 0/1 (-safety) pad/24 h. Univariable and multivariable logistic regression models were fitted to test for predictor status of USL and prostatic apex variants, defined in mpMRI measurements. Results: Of 68 eligible patients, rate of mid-term urinary continence was 81% (n = 55). Median coronal (15.1 vs. 12.5 mm) and sagittal (15.4 vs. 11.1 mm) USL were longer in patients reporting urinary continence in mid-term follow-up (both p < 0.01). No difference was recorded for prostatic apex variants distribution (Lee-type) between continent vs. incontinent patients (p = 0.4). In separate multivariable logistic regression models, coronal (odds ratio (OR): 1.35) and sagittal (OR: 1.67) USL, but not Lee-type, were independent predictors for mid-term continence. Conclusion: USL, but not apex anatomy, in preoperative mpMRI was associated with higher rates of urinary continence at mid-term follow-up.
MetadatenAuthor: | Robert Benedikt HöhORCiDGND, Mike WenzelORCiDGND, Matthias Müller, Clarissa WittlerGND, Eva Schlenke, Jan L. HohenhorstORCiD, Jens KöllermannORCiDGND, Thomas SteuberGND, Markus GraefenORCiDGND, Derya TilkiORCiDGND, Simon BernatzORCiDGND, Pierre I. Karakiewicz, Felix PreißerORCiDGND, Andreas BeckerGND, Luis KluthORCiDGND, Philipp MandelORCiDGND, Felix ChunORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-831737 |
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DOI: | https://doi.org/10.3390/diagnostics12030701 |
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ISSN: | 2075-4418 |
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Parent Title (English): | Diagnostics |
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Publisher: | MDPI |
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Place of publication: | Basel |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/03/13 |
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Date of first Publication: | 2022/03/13 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/05/07 |
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Tag: | Lee-type; apex; functional outcome; membranous urethra; mid-term urinary continence; prostate cancer; radical prostatectomy |
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Volume: | 12 |
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Issue: | 3, art. 701 |
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Article Number: | 701 |
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Page Number: | 13 |
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First Page: | 1 |
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Last Page: | 13 |
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HeBIS-PPN: | 520909194 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
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